Gene name Accession Number Gene CDS length HGNC ID Sample name ID_sample ID_tumour Primary site Site subtype 1 Site subtype 2 Site subtype 3 Primary histology Histology subtype 1 Histology subtype 2 Histology subtype 3 Genome-wide screen GENOMIC_MUTATION_ID LEGACY_MUTATION_ID MUTATION_ID Mutation CDS Mutation AA Mutation Description Mutation zygosity LOH GRCh Mutation genome position Mutation strand Resistance Mutation FATHMM prediction FATHMM score Mutation somatic status Pubmed_PMID ID_STUDY Sample Type Tumour origin Age HGVSP HGVSC HGVSG SYNE1_ENST00000367253 ENST00000367253.8 5178 17089 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105842737 COSM10012866 111221864 c.85C>T p.Q29* Substitution - Nonsense 38 6:152540004-152540004 - - PATHOGENIC .9583 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000356222.4:p.Gln29Ter ENST00000367253.8:c.85C>T 6:g.152540004G>A FAM131B ENST00000443739.6 1083 22202 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV58373157 COSM5872106 127860683 c.979C>T p.R327* Substitution - Nonsense 38 7:143356654-143356654 - - PATHOGENIC .82823 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000410603.2:p.Arg327Ter ENST00000443739.6:c.979C>T 7:g.143356654G>A CR1_ENST00000367052 ENST00000367052.6 6120 2334 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65455974 COSM341835 110438241 c.5308G>T p.E1770* Substitution - Nonsense 38 1:207614486-207614486 + - PATHOGENIC .82817 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000356019.1:p.Glu1770Ter ENST00000367052.6:c.5308G>T 1:g.207614486G>T CR1_ENST00000367052 ENST00000367052.6 6120 2334 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65455967 COSM301989 110438019 c.5230C>T p.R1744* Substitution - Nonsense 38 1:207614408-207614408 + - NEUTRAL .07353 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000356019.1:p.Arg1744Ter ENST00000367052.6:c.5230C>T 1:g.207614408C>T VPS13A_ENST00000645632 ENST00000645632.1 9210 1908 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105908792 COSM10012972 178155022 c.2191C>T p.R731* Substitution - Nonsense 38 9:77252255-77252255 + - PATHOGENIC .96696 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000496361.1:p.Arg731Ter ENST00000645632.1:c.2191C>T 9:g.77252255C>T FYB1 ENST00000512982.3 2520 4036 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105917563 COSM10012955 145688519 c.133A>T p.R45* Substitution - Nonsense 38 5:39202858-39202858 - - PATHOGENIC .9276 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000425845.2:p.Arg45Ter ENST00000512982.3:c.133A>T 5:g.39202858T>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 C1981 2897773 2752072 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105863715 COSM9966014 104562364 c.1545C>A p.C515* Substitution - Nonsense 38 7:55161545-55161545 + - PATHOGENIC .9683 Variant of unknown origin 31477716 surgery-fixed NS 47 ENSP00000345973.2:p.Cys515Ter ENST00000344576.6:c.1545C>A 7:g.55161545C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 BL-17-K13274 2905590 2759846 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864138 COSM9997840 104581132 c.1303C>T p.Q435* Substitution - Nonsense 38 7:55160143-55160143 + - PATHOGENIC .9567 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000345973.2:p.Gln435Ter ENST00000344576.6:c.1303C>T 7:g.55160143C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-69-7765-01 1914039 1802321 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51790518 COSM6178052 104594005 c.1456C>T p.Q486* Substitution - Nonsense 38 7:55160296-55160296 + - PATHOGENIC .99317 Variant of unknown origin 417 fresh/frozen - NOS primary 56 ENSP00000345973.2:p.Gln486Ter ENST00000344576.6:c.1456C>T 7:g.55160296C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 BL-17-R06450 2905627 2759883 NS NS NS NS malignant_melanoma NS NS NS n COSV105864534 COSM9990949 104592417 c.154C>T p.Q52* Substitution - Nonsense 38 7:55142351-55142351 + - PATHOGENIC .86004 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000345973.2:p.Gln52Ter ENST00000344576.6:c.154C>T 7:g.55142351C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 DND41 1760521 1665124 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51782203 COSM327143 104564599 c.211C>T p.Q71* Substitution - Nonsense 38 7:55142408-55142408 + - PATHOGENIC .91839 Variant of unknown origin 22675565 cell-line NS ENSP00000345973.2:p.Gln71Ter ENST00000344576.6:c.211C>T 7:g.55142408C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 KM12 2301990 2167273 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51772793 COSM1673192 104564131 c.1717G>T p.G573* Substitution - Nonsense het 38 7:55163818-55163818 + - PATHOGENIC .99807 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000345973.2:p.Gly573Ter ENST00000344576.6:c.1717G>T 7:g.55163818G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2579713 2579713 2441050 NS NS NS NS malignant_melanoma NS NS NS n COSV51850302 COSM6005744 104569560 c.1741C>T p.Q581* Substitution - Nonsense 38 7:55165298-55165298 + - NEUTRAL .15904 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000345973.2:p.Gln581Ter ENST00000344576.6:c.1741C>T 7:g.55165298C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 143 2748115 2606818 stomach NS NS NS carcinoma NS NS NS y COSV99286726 COSM8594240 104590828 c.1198G>T p.E400* Substitution - Nonsense 38 7:55156823-55156823 + - PATHOGENIC .99626 Confirmed somatic variant 683 NS primary ENSP00000345973.2:p.Glu400Ter ENST00000344576.6:c.1198G>T 7:g.55156823G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GCTK_315_T 2747417 2606120 stomach NS NS NS carcinoma NS NS NS y COSV51812362 COSM4773811 104566632 c.599G>A p.W200* Substitution - Nonsense 38 7:55151333-55151333 + - PATHOGENIC .99472 Confirmed somatic variant 683 NS primary ENSP00000345973.2:p.Trp200Ter ENST00000344576.6:c.599G>A 7:g.55151333G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GC13 2896794 2751142 placenta NS NS NS choriocarcinoma NS NS NS y COSV105863775 COSM9953653 104566046 c.2005G>T p.G669* Substitution - Nonsense 38 7:55170431-55170431 + - NEUTRAL .01536 Confirmed somatic variant 33319857 surgery-fixed metastasis 39 ENSP00000345973.2:p.Gly669Ter ENST00000344576.6:c.2005G>T 7:g.55170431G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 5-VS017-T2 2869838 2724835 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV105110022 COSM9698037 104596228 c.2010G>A p.W670* Substitution - Nonsense 38 7:55170436-55170436 + - NEUTRAL .00045 Confirmed somatic variant 26950094 surgery fresh/frozen NS 90 ENSP00000345973.2:p.Trp670Ter ENST00000344576.6:c.2010G>A 7:g.55170436G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 KM12 1998451 1883523 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51772793 COSM1673192 104564131 c.1717G>T p.G573* Substitution - Nonsense het 38 7:55163818-55163818 + - PATHOGENIC .99807 Confirmed somatic variant 23856246 cell-line primary ENSP00000345973.2:p.Gly573Ter ENST00000344576.6:c.1717G>T 7:g.55163818G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006754-T01-IM5 2723133 2581954 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51850302 COSM6005744 104569560 c.1741C>T p.Q581* Substitution - Nonsense het 38 7:55165298-55165298 + - NEUTRAL .15904 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Gln581Ter ENST00000344576.6:c.1741C>T 7:g.55165298C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0211-02 2120254 1994490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51804002 COSM3412186 104585739 c.826C>T p.Q276* Substitution - Nonsense 38 7:55154089-55154089 + - PATHOGENIC .94288 Confirmed somatic variant 329 NS NS 48 ENSP00000345973.2:p.Gln276Ter ENST00000344576.6:c.826C>T 7:g.55154089C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 YUROG 2439363 2302204 skin NS NS NS malignant_melanoma NS NS NS y COSV51803180 COSM5407716 104594079 c.622C>T p.Q208* Substitution - Nonsense het 38 7:55151356-55151356 + - PATHOGENIC .99214 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 58 ENSP00000345973.2:p.Gln208Ter ENST00000344576.6:c.622C>T 7:g.55151356C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-B5-A11E-01 1783399 1687398 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51772740 COSM3881824 104574325 c.1591C>T p.R531* Substitution - Nonsense 38 7:55161591-55161591 + - PATHOGENIC .9543 Confirmed somatic variant 419 fresh/frozen - NOS primary 53 ENSP00000345973.2:p.Arg531Ter ENST00000344576.6:c.1591C>T 7:g.55161591C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-AG-3881-01 1651557 1566344 large_intestine rectum NS NS NS NS NS NS y COSV99292247 COSM7522737 104584282 c.1015G>T p.G339* Substitution - Nonsense 38 7:55156541-55156541 + - PATHOGENIC .99616 Confirmed somatic variant 375 NS primary 83 ENSP00000345973.2:p.Gly339Ter ENST00000344576.6:c.1015G>T 7:g.55156541G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-B5-A1MX-01 2198273 2066551 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51772793 COSM1673192 104564131 c.1717G>T p.G573* Substitution - Nonsense 38 7:55163818-55163818 + - PATHOGENIC .99807 Confirmed somatic variant 419 NS NS 47 ENSP00000345973.2:p.Gly573Ter ENST00000344576.6:c.1717G>T 7:g.55163818G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GC_315T-GC_315N 2324594 2189703 stomach NS NS NS carcinoma diffuse_adenocarcinoma NS NS y COSV51812362 COSM4773811 104566632 c.599G>A p.W200* Substitution - Nonsense 38 7:55151333-55151333 + - PATHOGENIC .99472 Confirmed somatic variant 24816255 surgery fresh/frozen NS ENSP00000345973.2:p.Trp200Ter ENST00000344576.6:c.599G>A 7:g.55151333G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 6481_CLM 2500985 2363336 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51805522 COSM5757058 104568511 c.1431G>A p.W477* Substitution - Nonsense 38 7:55160271-55160271 + - PATHOGENIC .98844 Confirmed somatic variant 26109429 fresh/frozen - NOS metastasis 60 ENSP00000345973.2:p.Trp477Ter ENST00000344576.6:c.1431G>A 7:g.55160271G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-CG-5726-01 2198104 2066382 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51772740 COSM3881824 104574325 c.1591C>T p.R531* Substitution - Nonsense 38 7:55161591-55161591 + - PATHOGENIC .9543 Confirmed somatic variant 541 NS NS 73 ENSP00000345973.2:p.Arg531Ter ENST00000344576.6:c.1591C>T 7:g.55161591C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 ESCC-248T 2186150 2054447 oesophagus NS NS NS carcinoma NS NS NS y COSV51852005 COSM3942265 104563980 c.1993G>T p.E665* Substitution - Nonsense 38 7:55170419-55170419 + - NEUTRAL .03667 Confirmed somatic variant 582 NS NS ENSP00000345973.2:p.Glu665Ter ENST00000344576.6:c.1993G>T 7:g.55170419G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0014573-T01-IM6 2830595 2686410 breast NS NS NS carcinoma ductolobular_carcinoma NS NS n COSV104577192 COSM9359618 104582123 c.1773C>A p.C591* Substitution - Nonsense 38 7:55165330-55165330 + - NEUTRAL .48246 Confirmed somatic variant 30205045 surgery-fixed primary 68 ENSP00000345973.2:p.Cys591Ter ENST00000344576.6:c.1773C>A 7:g.55165330C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 10-428 1960462 1847022 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51833036 COSM1645315 104569273 c.933T>A p.C311* Substitution - Nonsense het 38 7:55155873-55155873 + - NEUTRAL .23167 Confirmed somatic variant 23700467 fresh/frozen - NOS primary ENSP00000345973.2:p.Cys311Ter ENST00000344576.6:c.933T>A 7:g.55155873T>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-D3-A8GI-06 2263025 2130009 skin NS NS NS malignant_melanoma NS NS NS y COSV51850302 COSM6005744 104569560 c.1741C>T p.Q581* Substitution - Nonsense 38 7:55165298-55165298 + - NEUTRAL .15904 Confirmed somatic variant 540 NS NS 68 ENSP00000345973.2:p.Gln581Ter ENST00000344576.6:c.1741C>T 7:g.55165298C>T VPS13A_ENST00000644843 ENST00000644843.1 9525 1908 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105908792 COSM10012972 178023646 c.2191C>T p.R731* Substitution - Nonsense 38 9:77252255-77252255 + - PATHOGENIC .96696 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000494809.1:p.Arg731Ter ENST00000644843.1:c.2191C>T 9:g.77252255C>T AHNAK2 ENST00000333244.5 17388 20125 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105905676 COSM10012954 105873399 c.82G>T p.E28* Substitution - Nonsense 38 14:104957646-104957646 - - .5298 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000353114.4:p.Glu28Ter ENST00000333244.5:c.82G>T 14:g.104957646C>A SYNE1_ENST00000466159 ENST00000466159.6 2265 17089 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105842737 COSM10012866 134467849 c.85C>T p.Q29* Substitution - Nonsense 38 6:152540004-152540004 - - PATHOGENIC .9583 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000446021.1:p.Gln29Ter ENST00000466159.6:c.85C>T 6:g.152540004G>A FAM131B_ENST00000409408 ENST00000409408.5 999 22202 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV58373157 COSM5872106 121299190 c.895C>T p.R299* Substitution - Nonsense 38 7:143356654-143356654 - - PATHOGENIC .82823 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000387017.1:p.Arg299Ter ENST00000409408.5:c.895C>T 7:g.143356654G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 C1981 2897773 2752072 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105863715 COSM9966014 106239958 c.1545C>A p.C515* Substitution - Nonsense 38 7:55161545-55161545 + - PATHOGENIC .9683 Variant of unknown origin 31477716 surgery-fixed NS 47 ENSP00000342376.3:p.Cys515Ter ENST00000342916.7:c.1545C>A 7:g.55161545C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 BL-17-K13274 2905590 2759846 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864138 COSM9997840 106254737 c.1303C>T p.Q435* Substitution - Nonsense 38 7:55160143-55160143 + - PATHOGENIC .9567 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000342376.3:p.Gln435Ter ENST00000342916.7:c.1303C>T 7:g.55160143C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-69-7765-01 1914039 1802321 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51790518 COSM6178052 106267958 c.1456C>T p.Q486* Substitution - Nonsense 38 7:55160296-55160296 + - PATHOGENIC .99317 Variant of unknown origin 417 fresh/frozen - NOS primary 56 ENSP00000342376.3:p.Gln486Ter ENST00000342916.7:c.1456C>T 7:g.55160296C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 BL-17-R06450 2905627 2759883 NS NS NS NS malignant_melanoma NS NS NS n COSV105864534 COSM9990949 106266139 c.154C>T p.Q52* Substitution - Nonsense 38 7:55142351-55142351 + - PATHOGENIC .86004 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000342376.3:p.Gln52Ter ENST00000342916.7:c.154C>T 7:g.55142351C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 DND41 1760521 1665124 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51782203 COSM327143 106241728 c.211C>T p.Q71* Substitution - Nonsense 38 7:55142408-55142408 + - PATHOGENIC .91839 Variant of unknown origin 22675565 cell-line NS ENSP00000342376.3:p.Gln71Ter ENST00000342916.7:c.211C>T 7:g.55142408C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 KM12 2301990 2167273 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51772793 COSM1673192 106241325 c.1717G>T p.G573* Substitution - Nonsense het 38 7:55163818-55163818 + - PATHOGENIC .99807 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000342376.3:p.Gly573Ter ENST00000342916.7:c.1717G>T 7:g.55163818G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2579713 2579713 2441050 NS NS NS NS malignant_melanoma NS NS NS n COSV51850302 COSM6005744 106246422 c.1741C>T p.Q581* Substitution - Nonsense 38 7:55165298-55165298 + - NEUTRAL .15904 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000342376.3:p.Gln581Ter ENST00000342916.7:c.1741C>T 7:g.55165298C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 143 2748115 2606818 stomach NS NS NS carcinoma NS NS NS y COSV99286726 COSM8594240 106264270 c.1198G>T p.E400* Substitution - Nonsense 38 7:55156823-55156823 + - PATHOGENIC .99626 Confirmed somatic variant 683 NS primary ENSP00000342376.3:p.Glu400Ter ENST00000342916.7:c.1198G>T 7:g.55156823G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GCTK_315_T 2747417 2606120 stomach NS NS NS carcinoma NS NS NS y COSV51812362 COSM4773811 106243650 c.599G>A p.W200* Substitution - Nonsense 38 7:55151333-55151333 + - PATHOGENIC .99472 Confirmed somatic variant 683 NS primary ENSP00000342376.3:p.Trp200Ter ENST00000342916.7:c.599G>A 7:g.55151333G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0211-02 2120254 1994490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51804002 COSM3412186 106258306 c.826C>T p.Q276* Substitution - Nonsense 38 7:55154089-55154089 + - PATHOGENIC .94288 Confirmed somatic variant 329 NS NS 48 ENSP00000342376.3:p.Gln276Ter ENST00000342916.7:c.826C>T 7:g.55154089C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 YUROG 2439363 2302204 skin NS NS NS malignant_melanoma NS NS NS y COSV51803180 COSM5407716 106268074 c.622C>T p.Q208* Substitution - Nonsense het 38 7:55151356-55151356 + - PATHOGENIC .99214 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 58 ENSP00000342376.3:p.Gln208Ter ENST00000342916.7:c.622C>T 7:g.55151356C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 KM12 1998451 1883523 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51772793 COSM1673192 106241325 c.1717G>T p.G573* Substitution - Nonsense het 38 7:55163818-55163818 + - PATHOGENIC .99807 Confirmed somatic variant 23856246 cell-line primary ENSP00000342376.3:p.Gly573Ter ENST00000342916.7:c.1717G>T 7:g.55163818G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006754-T01-IM5 2723133 2581954 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51850302 COSM6005744 106246422 c.1741C>T p.Q581* Substitution - Nonsense het 38 7:55165298-55165298 + - NEUTRAL .15904 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Gln581Ter ENST00000342916.7:c.1741C>T 7:g.55165298C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-AG-3881-01 1651557 1566344 large_intestine rectum NS NS NS NS NS NS y COSV99292247 COSM7522737 106256961 c.1015G>T p.G339* Substitution - Nonsense 38 7:55156541-55156541 + - PATHOGENIC .99616 Confirmed somatic variant 375 NS primary 83 ENSP00000342376.3:p.Gly339Ter ENST00000342916.7:c.1015G>T 7:g.55156541G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 6481_CLM 2500985 2363336 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51805522 COSM5757058 106245322 c.1431G>A p.W477* Substitution - Nonsense 38 7:55160271-55160271 + - PATHOGENIC .98844 Confirmed somatic variant 26109429 fresh/frozen - NOS metastasis 60 ENSP00000342376.3:p.Trp477Ter ENST00000342916.7:c.1431G>A 7:g.55160271G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GC_315T-GC_315N 2324594 2189703 stomach NS NS NS carcinoma diffuse_adenocarcinoma NS NS y COSV51812362 COSM4773811 106243650 c.599G>A p.W200* Substitution - Nonsense 38 7:55151333-55151333 + - PATHOGENIC .99472 Confirmed somatic variant 24816255 surgery fresh/frozen NS ENSP00000342376.3:p.Trp200Ter ENST00000342916.7:c.599G>A 7:g.55151333G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-B5-A11E-01 1783399 1687398 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51772740 COSM3881824 106250445 c.1591C>T p.R531* Substitution - Nonsense 38 7:55161591-55161591 + - PATHOGENIC .9543 Confirmed somatic variant 419 fresh/frozen - NOS primary 53 ENSP00000342376.3:p.Arg531Ter ENST00000342916.7:c.1591C>T 7:g.55161591C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-B5-A1MX-01 2198273 2066551 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51772793 COSM1673192 106241325 c.1717G>T p.G573* Substitution - Nonsense 38 7:55163818-55163818 + - PATHOGENIC .99807 Confirmed somatic variant 419 NS NS 47 ENSP00000342376.3:p.Gly573Ter ENST00000342916.7:c.1717G>T 7:g.55163818G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-CG-5726-01 2198104 2066382 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51772740 COSM3881824 106250445 c.1591C>T p.R531* Substitution - Nonsense 38 7:55161591-55161591 + - PATHOGENIC .9543 Confirmed somatic variant 541 NS NS 73 ENSP00000342376.3:p.Arg531Ter ENST00000342916.7:c.1591C>T 7:g.55161591C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0014573-T01-IM6 2830595 2686410 breast NS NS NS carcinoma ductolobular_carcinoma NS NS n COSV104577192 COSM9359618 106255403 c.1773C>A p.C591* Substitution - Nonsense 38 7:55165330-55165330 + - NEUTRAL .48246 Confirmed somatic variant 30205045 surgery-fixed primary 68 ENSP00000342376.3:p.Cys591Ter ENST00000342916.7:c.1773C>A 7:g.55165330C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 10-428 1960462 1847022 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51833036 COSM1645315 106246129 c.933T>A p.C311* Substitution - Nonsense het 38 7:55155873-55155873 + - NEUTRAL .23167 Confirmed somatic variant 23700467 fresh/frozen - NOS primary ENSP00000342376.3:p.Cys311Ter ENST00000342916.7:c.933T>A 7:g.55155873T>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-D3-A8GI-06 2263025 2130009 skin NS NS NS malignant_melanoma NS NS NS y COSV51850302 COSM6005744 106246422 c.1741C>T p.Q581* Substitution - Nonsense 38 7:55165298-55165298 + - NEUTRAL .15904 Confirmed somatic variant 540 NS NS 68 ENSP00000342376.3:p.Gln581Ter ENST00000342916.7:c.1741C>T 7:g.55165298C>T SYNE1_ENST00000610489 ENST00000610489.1 1434 17089 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105842737 COSM10012866 167831059 c.34C>T p.Q12* Substitution - Nonsense 38 6:152540004-152540004 - - PATHOGENIC .9583 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000481873.1:p.Gln12Ter ENST00000610489.1:c.34C>T 6:g.152540004G>A SYNE1_ENST00000423061 ENST00000423061.5 26250 17089 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105842737 COSM10012866 123747421 c.85C>T p.Q29* Substitution - Nonsense 38 6:152540004-152540004 - - PATHOGENIC .9583 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000396024.1:p.Gln29Ter ENST00000423061.5:c.85C>T 6:g.152540004G>A VPS13A_ENST00000376636 ENST00000376636.7 9408 1908 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105908792 COSM10012972 112063413 c.2191C>T p.R731* Substitution - Nonsense 38 9:77252255-77252255 + - PATHOGENIC .96696 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000365823.3:p.Arg731Ter ENST00000376636.7:c.2191C>T 9:g.77252255C>T TMEM255B ENST00000375353.4 981 28297 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV100943364 COSM7454211 112669084 c.211G>T p.G71* Substitution - Nonsense 38 13:113769119-113769119 + - PATHOGENIC .97575 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000364502.3:p.Gly71Ter ENST00000375353.4:c.211G>T 13:g.113769119G>T FAM131B_ENST00000409578 ENST00000409578.5 1047 22202 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV58373157 COSM5872106 122444982 c.943C>T p.R315* Substitution - Nonsense 38 7:143356654-143356654 - - PATHOGENIC .82823 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000386568.1:p.Arg315Ter ENST00000409578.5:c.943C>T 7:g.143356654G>A CR1_ENST00000400960 ENST00000400960.7 6120 2334 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65455974 COSM341835 121788357 c.5308G>T p.E1770* Substitution - Nonsense 38 1:207614486-207614486 + - PATHOGENIC .82817 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000383744.2:p.Glu1770Ter ENST00000400960.7:c.5308G>T 1:g.207614486G>T CR1_ENST00000367053 ENST00000367053.6 6120 2334 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65455974 COSM341835 110464151 c.5308G>T p.E1770* Substitution - Nonsense 38 1:207614486-207614486 + - PATHOGENIC .82817 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000356020.1:p.Glu1770Ter ENST00000367053.6:c.5308G>T 1:g.207614486G>T CR1_ENST00000400960 ENST00000400960.7 6120 2334 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65455967 COSM301989 121788072 c.5230C>T p.R1744* Substitution - Nonsense 38 1:207614408-207614408 + - NEUTRAL .07353 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000383744.2:p.Arg1744Ter ENST00000400960.7:c.5230C>T 1:g.207614408C>T VPS13A_ENST00000376634 ENST00000376634.8 9210 1908 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105908792 COSM10012972 112025971 c.2191C>T p.R731* Substitution - Nonsense 38 9:77252255-77252255 + - PATHOGENIC .96696 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000365821.4:p.Arg731Ter ENST00000376634.8:c.2191C>T 9:g.77252255C>T CR1_ENST00000367053 ENST00000367053.6 6120 2334 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65455967 COSM301989 110463889 c.5230C>T p.R1744* Substitution - Nonsense 38 1:207614408-207614408 + - NEUTRAL .07353 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000356020.1:p.Arg1744Ter ENST00000367053.6:c.5230C>T 1:g.207614408C>T VPS13A_ENST00000643348 ENST00000643348.1 9288 1908 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105908792 COSM10012972 174925806 c.2191C>T p.R731* Substitution - Nonsense 38 9:77252255-77252255 + - PATHOGENIC .96696 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000493592.1:p.Arg731Ter ENST00000643348.1:c.2191C>T 9:g.77252255C>T FAM131B_ENST00000409346 ENST00000409346.5 999 22202 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV58373157 COSM5872106 120818789 c.895C>T p.R299* Substitution - Nonsense 38 7:143356654-143356654 - - PATHOGENIC .82823 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000386984.1:p.Arg299Ter ENST00000409346.5:c.895C>T 7:g.143356654G>A SYNE1 ENST00000367255.9 26394 17089 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105842737 COSM10012866 111448668 c.85C>T p.Q29* Substitution - Nonsense 38 6:152540004-152540004 - - PATHOGENIC .9583 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000356224.5:p.Gln29Ter ENST00000367255.9:c.85C>T 6:g.152540004G>A EGFR ENST00000275493.6 3633 3236 P-0012072-T01-IM5 2727215 2586036 haematopoietic_and_lymphoid_tissue soft_tissue NS NS lymphoid_neoplasm peripheral_T_cell_lymphoma_unspecified NS NS n COSV51815037 COSM6987691 99422542 c.3562A>T p.K1188* Substitution - Nonsense het 38 7:55205546-55205546 + - PATHOGENIC .92764 Variant of unknown origin 28481359 surgery-fixed primary ENSP00000275493.2:p.Lys1188Ter ENST00000275493.6:c.3562A>T 7:g.55205546A>T EGFR ENST00000275493.6 3633 3236 C1981 2897773 2752072 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105863715 COSM9966014 99375464 c.1545C>A p.C515* Substitution - Nonsense 38 7:55161545-55161545 + - PATHOGENIC .9683 Variant of unknown origin 31477716 surgery-fixed NS 47 ENSP00000275493.2:p.Cys515Ter ENST00000275493.6:c.1545C>A 7:g.55161545C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 C1981 2897773 2752072 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105863715 COSM9966014 133203766 c.1410C>A p.C470* Substitution - Nonsense 38 7:55161545-55161545 + - PATHOGENIC .9683 Variant of unknown origin 31477716 surgery-fixed NS 47 ENSP00000415559.1:p.Cys470Ter ENST00000455089.5:c.1410C>A 7:g.55161545C>A EGFR ENST00000275493.6 3633 3236 983773 983773 899491 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51788192 COSM18487 99446622 c.2614G>T p.E872* Substitution - Nonsense 38 7:55191863-55191863 + - PATHOGENIC .9903 Variant of unknown origin 16707764 surgery fresh/frozen primary ENSP00000275493.2:p.Glu872Ter ENST00000275493.6:c.2614G>T 7:g.55191863G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 983773 983773 899491 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51788192 COSM18487 133270027 c.2479G>T p.E827* Substitution - Nonsense 38 7:55191863-55191863 + - PATHOGENIC .9903 Variant of unknown origin 16707764 surgery fresh/frozen primary ENSP00000415559.1:p.Glu827Ter ENST00000455089.5:c.2479G>T 7:g.55191863G>T EGFR ENST00000275493.6 3633 3236 TCGA-69-7765-01 1914039 1802321 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51790518 COSM6178052 99453108 c.1456C>T p.Q486* Substitution - Nonsense 38 7:55160296-55160296 + - PATHOGENIC .99317 Variant of unknown origin 417 fresh/frozen - NOS primary 56 ENSP00000275493.2:p.Gln486Ter ENST00000275493.6:c.1456C>T 7:g.55160296C>T EGFR ENST00000275493.6 3633 3236 BL-17-K13274 2905590 2759846 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864138 COSM9997840 99413593 c.1303C>T p.Q435* Substitution - Nonsense 38 7:55160143-55160143 + - PATHOGENIC .9567 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Gln435Ter ENST00000275493.6:c.1303C>T 7:g.55160143C>T EGFR ENST00000275493.6 3633 3236 2226764 2226764 2094499 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51798586 COSM4170218 99414137 c.2152_2153delinsTA p.L718* Substitution - Nonsense 38 7:55174011-55174012 + - Variant of unknown origin 24891042 NS NS ENSP00000275493.2:p.Leu718Ter ENST00000275493.6:c.2152_2153delinsTA 7:g.55174011_55174012delinsTA EGFR ENST00000275493.6 3633 3236 2561891 2561891 2423290 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM5985117 178381361 c.? p.C307* Substitution - Nonsense + - Variant of unknown origin 27588476 circulating tumour NS EGFR ENST00000275493.6 3633 3236 1602601 1602601 1521937 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM133707 178386771 c.? p.K728* Substitution - Nonsense + - Variant of unknown origin 22082647 surgery-fixed NS ENSP00000275493.2:p.Lys728Ter EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PEN-136 2843116 2698569 skin NS NS NS benign_melanocytic_nevus NS NS NS n COSV104577162 COSN32035351 133256428 c.3217C>T p.Q1073* Substitution - Nonsense 38 7:55202706-55202706 + - NEUTRAL .0525 Variant of unknown origin 27890785 surgery-fixed NS ENSP00000415559.1:p.Gln1073Ter ENST00000455089.5:c.3217C>T 7:g.55202706C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-69-7765-01 1914039 1802321 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51790518 COSM6178052 133276842 c.1321C>T p.Q441* Substitution - Nonsense 38 7:55160296-55160296 + - PATHOGENIC .99317 Variant of unknown origin 417 fresh/frozen - NOS primary 56 ENSP00000415559.1:p.Gln441Ter ENST00000455089.5:c.1321C>T 7:g.55160296C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-K13274 2905590 2759846 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864138 COSM9997840 133239851 c.1168C>T p.Q390* Substitution - Nonsense 38 7:55160143-55160143 + - PATHOGENIC .9567 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Gln390Ter ENST00000455089.5:c.1168C>T 7:g.55160143C>T EGFR ENST00000275493.6 3633 3236 BL-17-R06450 2905627 2759883 NS NS NS NS malignant_melanoma NS NS NS n COSV105864534 COSM9990949 99447155 c.154C>T p.Q52* Substitution - Nonsense 38 7:55142351-55142351 + - PATHOGENIC .86004 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Gln52Ter ENST00000275493.6:c.154C>T 7:g.55142351C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226764 2226764 2094499 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51798586 COSM4170218 133240272 c.2017_2018delinsTA p.L673* Substitution - Nonsense 38 7:55174011-55174012 + - Variant of unknown origin 24891042 NS NS ENSP00000415559.1:p.Leu673Ter ENST00000455089.5:c.2017_2018delinsTA 7:g.55174011_55174012delinsTA EGFR ENST00000275493.6 3633 3236 DND41 1760521 1665124 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51782203 COSM327143 99379320 c.211C>T p.Q71* Substitution - Nonsense 38 7:55142408-55142408 + - PATHOGENIC .91839 Variant of unknown origin 22675565 cell-line NS ENSP00000275493.2:p.Gln71Ter ENST00000275493.6:c.211C>T 7:g.55142408C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-R06450 2905627 2759883 NS NS NS NS malignant_melanoma NS NS NS n COSV105864534 COSM9990949 133270627 c.154C>T p.Q52* Substitution - Nonsense 38 7:55142351-55142351 + - PATHOGENIC .86004 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Gln52Ter ENST00000455089.5:c.154C>T 7:g.55142351C>T EGFR ENST00000275493.6 3633 3236 PD42094c 2894837 2749325 skin trunk NS NS malignant_melanoma superficial_spreading NS NS y COSV105110916 COSM9888722 99450774 c.2803C>T p.Q935* Substitution - Nonsense 38 7:55198818-55198818 + - PATHOGENIC .98269 Variant of unknown origin 33024263 surgery-fixed metastasis 62 ENSP00000275493.2:p.Gln935Ter ENST00000275493.6:c.2803C>T 7:g.55198818C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0012072-T01-IM5 2727215 2586036 haematopoietic_and_lymphoid_tissue soft_tissue NS NS lymphoid_neoplasm peripheral_T_cell_lymphoma_unspecified NS NS n COSV51815037 COSM6987691 132585626 c.3427A>T p.K1143* Substitution - Nonsense het 38 7:55205546-55205546 + - PATHOGENIC .92764 Variant of unknown origin 28481359 surgery-fixed primary ENSP00000395243.3:p.Lys1143Ter ENST00000454757.6:c.3427A>T 7:g.55205546A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DND41 1760521 1665124 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51782203 COSM327143 133207471 c.211C>T p.Q71* Substitution - Nonsense 38 7:55142408-55142408 + - PATHOGENIC .91839 Variant of unknown origin 22675565 cell-line NS ENSP00000415559.1:p.Gln71Ter ENST00000455089.5:c.211C>T 7:g.55142408C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 C1981 2897773 2752072 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105863715 COSM9966014 132548788 c.1410C>A p.C470* Substitution - Nonsense 38 7:55161545-55161545 + - PATHOGENIC .9683 Variant of unknown origin 31477716 surgery-fixed NS 47 ENSP00000395243.3:p.Cys470Ter ENST00000454757.6:c.1410C>A 7:g.55161545C>A EGFR ENST00000275493.6 3633 3236 CC27 2766421 2624640 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51766890 COSM13432 99385450 c.2193G>A p.W731* Substitution - Nonsense 38 7:55174730-55174730 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 29844865 surgery fresh/frozen NS 62 ENSP00000275493.2:p.Trp731Ter ENST00000275493.6:c.2193G>A 7:g.55174730G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD42094c 2894837 2749325 skin trunk NS NS malignant_melanoma superficial_spreading NS NS y COSV105110916 COSM9888722 133274033 c.2668C>T p.Q890* Substitution - Nonsense 38 7:55198818-55198818 + - PATHOGENIC .98269 Variant of unknown origin 33024263 surgery-fixed metastasis 62 ENSP00000415559.1:p.Gln890Ter ENST00000455089.5:c.2668C>T 7:g.55198818C>T EGFR ENST00000275493.6 3633 3236 TCGA-AP-A051-01 1783330 1687329 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51848812 COSM1090890 99388966 c.2481C>A p.Y827* Substitution - Nonsense het 38 7:55191730-55191730 + - PATHOGENIC .91962 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000275493.2:p.Tyr827Ter ENST00000275493.6:c.2481C>A 7:g.55191730C>A EGFR ENST00000275493.6 3633 3236 1766932 1766932 1671252 small_intestine duodenum NS NS carcinoma adenocarcinoma NS NS n COSV51835832 COSM329080 99401393 c.2101C>T p.Q701* Substitution - Nonsense het 38 7:55173960-55173960 + - PATHOGENIC .97446 Variant of unknown origin 22422135 surgery - NOS NS ENSP00000275493.2:p.Gln701Ter ENST00000275493.6:c.2101C>T 7:g.55173960C>T EGFR ENST00000275493.6 3633 3236 TCGA-BG-A0VZ-01 1783443 1687442 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51812193 COSM1090883 99380122 c.2005C>T p.R669* Substitution - Nonsense hom 38 7:55173068-55173068 + - PATHOGENIC .96775 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 58 ENSP00000275493.2:p.Arg669Ter ENST00000275493.6:c.2005C>T 7:g.55173068C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CC27 2766421 2624640 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51766890 COSM13432 133213936 c.2058G>A p.W686* Substitution - Nonsense 38 7:55174730-55174730 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 29844865 surgery fresh/frozen NS 62 ENSP00000415559.1:p.Trp686Ter ENST00000455089.5:c.2058G>A 7:g.55174730G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 983773 983773 899491 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51788192 COSM18487 132605361 c.2479G>T p.E827* Substitution - Nonsense 38 7:55191863-55191863 + - PATHOGENIC .9903 Variant of unknown origin 16707764 surgery fresh/frozen primary ENSP00000395243.3:p.Glu827Ter ENST00000454757.6:c.2479G>T 7:g.55191863G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BG-A0VZ-01 1783443 1687442 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51812193 COSM1090883 133208308 c.1870C>T p.R624* Substitution - Nonsense hom 38 7:55173068-55173068 + - PATHOGENIC .96775 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 58 ENSP00000415559.1:p.Arg624Ter ENST00000455089.5:c.1870C>T 7:g.55173068C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226860 2226860 2094595 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51840582 COSM4170224 133241166 c.2348T>A p.L783* Substitution - Nonsense 38 7:55191732-55191732 + - PATHOGENIC .9807 Variant of unknown origin 24891042 NS NS ENSP00000415559.1:p.Leu783Ter ENST00000455089.5:c.2348T>A 7:g.55191732T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1766932 1766932 1671252 small_intestine duodenum NS NS carcinoma adenocarcinoma NS NS n COSV51835832 COSM329080 133226777 c.1966C>T p.Q656* Substitution - Nonsense het 38 7:55173960-55173960 + - PATHOGENIC .97446 Variant of unknown origin 22422135 surgery - NOS NS ENSP00000415559.1:p.Gln656Ter ENST00000455089.5:c.1966C>T 7:g.55173960C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-69-7765-01 1914039 1802321 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51790518 COSM6178052 132612775 c.1321C>T p.Q441* Substitution - Nonsense 38 7:55160296-55160296 + - PATHOGENIC .99317 Variant of unknown origin 417 fresh/frozen - NOS primary 56 ENSP00000395243.3:p.Gln441Ter ENST00000454757.6:c.1321C>T 7:g.55160296C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-17-K13274 2905590 2759846 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864138 COSM9997840 132579102 c.1168C>T p.Q390* Substitution - Nonsense 38 7:55160143-55160143 + - PATHOGENIC .9567 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Gln390Ter ENST00000454757.6:c.1168C>T 7:g.55160143C>T EGFR ENST00000275493.6 3633 3236 2226860 2226860 2094595 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51840582 COSM4170224 99415365 c.2483T>A p.L828* Substitution - Nonsense 38 7:55191732-55191732 + - PATHOGENIC .9807 Variant of unknown origin 24891042 NS NS ENSP00000275493.2:p.Leu828Ter ENST00000275493.6:c.2483T>A 7:g.55191732T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1179041 1179041 1091003 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51766890 COSM13432 133213936 c.2058G>A p.W686* Substitution - Nonsense hom 38 7:55174730-55174730 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 19190079 surgery-fixed primary 53 ENSP00000415559.1:p.Trp686Ter ENST00000455089.5:c.2058G>A 7:g.55174730G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-J09769 2905113 2759369 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS n COSV104577162 COSN32035351 133256428 c.3217C>T p.Q1073* Substitution - Nonsense 38 7:55202706-55202706 + - NEUTRAL .0525 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Gln1073Ter ENST00000455089.5:c.3217C>T 7:g.55202706C>T EGFR ENST00000275493.6 3633 3236 1179041 1179041 1091003 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51766890 COSM13432 99385450 c.2193G>A p.W731* Substitution - Nonsense hom 38 7:55174730-55174730 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 19190079 surgery-fixed primary 53 ENSP00000275493.2:p.Trp731Ter ENST00000275493.6:c.2193G>A 7:g.55174730G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226764 2226764 2094499 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51798586 COSM4170218 132579415 c.2017_2018delinsTA p.L673* Substitution - Nonsense 38 7:55174011-55174012 + - Variant of unknown origin 24891042 NS NS ENSP00000395243.3:p.Leu673Ter ENST00000454757.6:c.2017_2018delinsTA 7:g.55174011_55174012delinsTA EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-17-R06450 2905627 2759883 NS NS NS NS malignant_melanoma NS NS NS n COSV105864534 COSM9990949 132605973 c.154C>T p.Q52* Substitution - Nonsense 38 7:55142351-55142351 + - PATHOGENIC .86004 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Gln52Ter ENST00000454757.6:c.154C>T 7:g.55142351C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KM12 2301990 2167273 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51772793 COSM1673192 133206559 c.1582G>T p.G528* Substitution - Nonsense het 38 7:55163818-55163818 + - PATHOGENIC .99807 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000415559.1:p.Gly528Ter ENST00000455089.5:c.1582G>T 7:g.55163818G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AP-A051-01 1783330 1687329 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51848812 COSM1090890 133216856 c.2346C>A p.Y782* Substitution - Nonsense het 38 7:55191730-55191730 + - PATHOGENIC .91962 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000415559.1:p.Tyr782Ter ENST00000455089.5:c.2346C>A 7:g.55191730C>A EGFR ENST00000275493.6 3633 3236 KM12 2301990 2167273 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51772793 COSM1673192 99378463 c.1717G>T p.G573* Substitution - Nonsense het 38 7:55163818-55163818 + - PATHOGENIC .99807 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000275493.2:p.Gly573Ter ENST00000275493.6:c.1717G>T 7:g.55163818G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DND41 1760521 1665124 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51782203 COSM327143 132552464 c.211C>T p.Q71* Substitution - Nonsense 38 7:55142408-55142408 + - PATHOGENIC .91839 Variant of unknown origin 22675565 cell-line NS ENSP00000395243.3:p.Gln71Ter ENST00000454757.6:c.211C>T 7:g.55142408C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD42094c 2894837 2749325 skin trunk NS NS malignant_melanoma superficial_spreading NS NS y COSV105110916 COSM9888722 132609586 c.2668C>T p.Q890* Substitution - Nonsense 38 7:55198818-55198818 + - PATHOGENIC .98269 Variant of unknown origin 33024263 surgery-fixed metastasis 62 ENSP00000395243.3:p.Gln890Ter ENST00000454757.6:c.2668C>T 7:g.55198818C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2579713 2579713 2441050 NS NS NS NS malignant_melanoma NS NS NS n COSV51850302 COSM6005744 133218541 c.1606C>T p.Q536* Substitution - Nonsense 38 7:55165298-55165298 + - NEUTRAL .15904 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000415559.1:p.Gln536Ter ENST00000455089.5:c.1606C>T 7:g.55165298C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CC27 2766421 2624640 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51766890 COSM13432 132557859 c.2058G>A p.W686* Substitution - Nonsense 38 7:55174730-55174730 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 29844865 surgery fresh/frozen NS 62 ENSP00000395243.3:p.Trp686Ter ENST00000454757.6:c.2058G>A 7:g.55174730G>A EGFR ENST00000275493.6 3633 3236 2579713 2579713 2441050 NS NS NS NS malignant_melanoma NS NS NS n COSV51850302 COSM6005744 99390882 c.1741C>T p.Q581* Substitution - Nonsense 38 7:55165298-55165298 + - NEUTRAL .15904 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000275493.2:p.Gln581Ter ENST00000275493.6:c.1741C>T 7:g.55165298C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BG-A0VZ-01 1783443 1687442 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51812193 COSM1090883 132553243 c.1870C>T p.R624* Substitution - Nonsense hom 38 7:55173068-55173068 + - PATHOGENIC .96775 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 58 ENSP00000395243.3:p.Arg624Ter ENST00000454757.6:c.1870C>T 7:g.55173068C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1766932 1766932 1671252 small_intestine duodenum NS NS carcinoma adenocarcinoma NS NS n COSV51835832 COSM329080 132569462 c.1966C>T p.Q656* Substitution - Nonsense het 38 7:55173960-55173960 + - PATHOGENIC .97446 Variant of unknown origin 22422135 surgery - NOS NS ENSP00000395243.3:p.Gln656Ter ENST00000454757.6:c.1966C>T 7:g.55173960C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1179041 1179041 1091003 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51766890 COSM13432 132557859 c.2058G>A p.W686* Substitution - Nonsense hom 38 7:55174730-55174730 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 19190079 surgery-fixed primary 53 ENSP00000395243.3:p.Trp686Ter ENST00000454757.6:c.2058G>A 7:g.55174730G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226860 2226860 2094595 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51840582 COSM4170224 132580096 c.2348T>A p.L783* Substitution - Nonsense 38 7:55191732-55191732 + - PATHOGENIC .9807 Variant of unknown origin 24891042 NS NS ENSP00000395243.3:p.Leu783Ter ENST00000454757.6:c.2348T>A 7:g.55191732T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KM12 2301990 2167273 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51772793 COSM1673192 132551625 c.1582G>T p.G528* Substitution - Nonsense het 38 7:55163818-55163818 + - PATHOGENIC .99807 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000395243.3:p.Gly528Ter ENST00000454757.6:c.1582G>T 7:g.55163818G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AP-A051-01 1783330 1687329 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51848812 COSM1090890 132560773 c.2346C>A p.Y782* Substitution - Nonsense het 38 7:55191730-55191730 + - PATHOGENIC .91962 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000395243.3:p.Tyr782Ter ENST00000454757.6:c.2346C>A 7:g.55191730C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2579713 2579713 2441050 NS NS NS NS malignant_melanoma NS NS NS n COSV51850302 COSM6005744 132562276 c.1606C>T p.Q536* Substitution - Nonsense 38 7:55165298-55165298 + - NEUTRAL .15904 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000395243.3:p.Gln536Ter ENST00000454757.6:c.1606C>T 7:g.55165298C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 24 2570197 2431494 skin chest_wall NS NS adnexal_tumour sebaceous_carcinoma NS NS n COSV51766890 COSM13432 133213936 c.2058G>A p.W686* Substitution - Nonsense 38 7:55174730-55174730 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 79 ENSP00000415559.1:p.Trp686Ter ENST00000455089.5:c.2058G>A 7:g.55174730G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 24 2570197 2431494 skin chest_wall NS NS adnexal_tumour sebaceous_carcinoma NS NS n COSV51766890 COSM13432 132557859 c.2058G>A p.W686* Substitution - Nonsense 38 7:55174730-55174730 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 79 ENSP00000395243.3:p.Trp686Ter ENST00000454757.6:c.2058G>A 7:g.55174730G>A EGFR ENST00000275493.6 3633 3236 24 2570197 2431494 skin chest_wall NS NS adnexal_tumour sebaceous_carcinoma NS NS n COSV51766890 COSM13432 99385450 c.2193G>A p.W731* Substitution - Nonsense 38 7:55174730-55174730 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 79 ENSP00000275493.2:p.Trp731Ter ENST00000275493.6:c.2193G>A 7:g.55174730G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1145848 1145848 1058303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790203 COSM27641 133241972 c.2047A>T p.K683* Substitution - Nonsense het 38 7:55174041-55174041 + - PATHOGENIC .96836 Confirmed somatic variant 18628075 surgery-fixed primary 61 ENSP00000415559.1:p.Lys683Ter ENST00000455089.5:c.2047A>T 7:g.55174041A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1145848 1145848 1058303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790203 COSM27641 132580861 c.2047A>T p.K683* Substitution - Nonsense het 38 7:55174041-55174041 + - PATHOGENIC .96836 Confirmed somatic variant 18628075 surgery-fixed primary 61 ENSP00000395243.3:p.Lys683Ter ENST00000454757.6:c.2047A>T 7:g.55174041A>T TCIM ENST00000315792.4 321 1357 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105878860 COSM10012933 104063797 c.136G>T p.E46* Substitution - Nonsense 38 8:40153668-40153668 + - PATHOGENIC .95413 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000319914.3:p.Glu46Ter ENST00000315792.4:c.136G>T 8:g.40153668G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000372-T01-IM3 2715143 2573964 skin scrotum NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51859555 COSM6910061 132562293 c.3442G>T p.E1148* Substitution - Nonsense het 38 7:55205561-55205561 + - PATHOGENIC .97398 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Glu1148Ter ENST00000454757.6:c.3442G>T 7:g.55205561G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 143 2748115 2606818 stomach NS NS NS carcinoma NS NS NS y COSV99286726 COSM8594240 132600687 c.1063G>T p.E355* Substitution - Nonsense 38 7:55156823-55156823 + - PATHOGENIC .99626 Confirmed somatic variant 683 NS primary ENSP00000395243.3:p.Glu355Ter ENST00000454757.6:c.1063G>T 7:g.55156823G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 143 2748115 2606818 stomach NS NS NS carcinoma NS NS NS y COSV99286726 COSM8594240 133264864 c.1063G>T p.E355* Substitution - Nonsense 38 7:55156823-55156823 + - PATHOGENIC .99626 Confirmed somatic variant 683 NS primary ENSP00000415559.1:p.Glu355Ter ENST00000455089.5:c.1063G>T 7:g.55156823G>T EGFR ENST00000275493.6 3633 3236 1145848 1145848 1058303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790203 COSM27641 99416310 c.2182A>T p.K728* Substitution - Nonsense het 38 7:55174041-55174041 + - PATHOGENIC .96836 Confirmed somatic variant 18628075 surgery-fixed primary 61 ENSP00000275493.2:p.Lys728Ter ENST00000275493.6:c.2182A>T 7:g.55174041A>T EGFR ENST00000275493.6 3633 3236 P-0000372-T01-IM3 2715143 2573964 skin scrotum NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51859555 COSM6910061 99390901 c.3577G>T p.E1193* Substitution - Nonsense het 38 7:55205561-55205561 + - PATHOGENIC .97398 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Glu1193Ter ENST00000275493.6:c.3577G>T 7:g.55205561G>T EGFR ENST00000275493.6 3633 3236 143 2748115 2606818 stomach NS NS NS carcinoma NS NS NS y COSV99286726 COSM8594240 99441690 c.1198G>T p.E400* Substitution - Nonsense 38 7:55156823-55156823 + - PATHOGENIC .99626 Confirmed somatic variant 683 NS primary ENSP00000275493.2:p.Glu400Ter ENST00000275493.6:c.1198G>T 7:g.55156823G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GCTK_315_T 2747417 2606120 stomach NS NS NS carcinoma NS NS NS y COSV51812362 COSM4773811 132556444 c.464G>A p.W155* Substitution - Nonsense 38 7:55151333-55151333 + - PATHOGENIC .99472 Confirmed somatic variant 683 NS primary ENSP00000395243.3:p.Trp155Ter ENST00000454757.6:c.464G>A 7:g.55151333G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0012249-T01-IM5 2727356 2586177 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51847220 COSM6983680 132598040 c.1915C>T p.Q639* Substitution - Nonsense het 38 7:55173113-55173113 + - PATHOGENIC .98858 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Gln639Ter ENST00000454757.6:c.1915C>T 7:g.55173113C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GCTK_315_T 2747417 2606120 stomach NS NS NS carcinoma NS NS NS y COSV51812362 COSM4773811 133212444 c.464G>A p.W155* Substitution - Nonsense 38 7:55151333-55151333 + - PATHOGENIC .99472 Confirmed somatic variant 683 NS primary ENSP00000415559.1:p.Trp155Ter ENST00000455089.5:c.464G>A 7:g.55151333G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0012249-T01-IM5 2727356 2586177 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51847220 COSM6983680 133261721 c.1915C>T p.Q639* Substitution - Nonsense het 38 7:55173113-55173113 + - PATHOGENIC .98858 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Gln639Ter ENST00000455089.5:c.1915C>T 7:g.55173113C>T EGFR ENST00000275493.6 3633 3236 GCTK_315_T 2747417 2606120 stomach NS NS NS carcinoma NS NS NS y COSV51812362 COSM4773811 99383844 c.599G>A p.W200* Substitution - Nonsense 38 7:55151333-55151333 + - PATHOGENIC .99472 Confirmed somatic variant 683 NS primary ENSP00000275493.2:p.Trp200Ter ENST00000275493.6:c.599G>A 7:g.55151333G>A EGFR ENST00000275493.6 3633 3236 P-0012249-T01-IM5 2727356 2586177 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51847220 COSM6983680 99438806 c.2050C>T p.Q684* Substitution - Nonsense het 38 7:55173113-55173113 + - PATHOGENIC .98858 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Gln684Ter ENST00000275493.6:c.2050C>T 7:g.55173113C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920114 920114 837193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766890 COSM13432 132557859 c.2058G>A p.W686* Substitution - Nonsense hom 38 7:55174730-55174730 + - PATHOGENIC .99879 Confirmed somatic variant 15623594 surgery-fixed NS 66 ENSP00000395243.3:p.Trp686Ter ENST00000454757.6:c.2058G>A 7:g.55174730G>A FYB1_ENST00000505428 ENST00000505428.5 2490 4036 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105917563 COSM10012955 143457535 c.103A>T p.R35* Substitution - Nonsense 38 5:39202858-39202858 - - PATHOGENIC .9276 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000427114.1:p.Arg35Ter ENST00000505428.5:c.103A>T 5:g.39202858T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920114 920114 837193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766890 COSM13432 133213936 c.2058G>A p.W686* Substitution - Nonsense hom 38 7:55174730-55174730 + - PATHOGENIC .99879 Confirmed somatic variant 15623594 surgery-fixed NS 66 ENSP00000415559.1:p.Trp686Ter ENST00000455089.5:c.2058G>A 7:g.55174730G>A EGFR ENST00000275493.6 3633 3236 920114 920114 837193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766890 COSM13432 99385450 c.2193G>A p.W731* Substitution - Nonsense hom 38 7:55174730-55174730 + - PATHOGENIC .99879 Confirmed somatic variant 15623594 surgery-fixed NS 66 ENSP00000275493.2:p.Trp731Ter ENST00000275493.6:c.2193G>A 7:g.55174730G>A FYB1_ENST00000351578 ENST00000351578.11 2352 4036 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105917563 COSM10012955 109216522 c.103A>T p.R35* Substitution - Nonsense 38 5:39202858-39202858 - - PATHOGENIC .9276 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000316460.7:p.Arg35Ter ENST00000351578.11:c.103A>T 5:g.39202858T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005212-T01-IM5 2721616 2580437 upper_aerodigestive_tract pharynx oropharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51859204 COSM6941837 132560396 c.3274G>T p.E1092* Substitution - Nonsense het 38 7:55205393-55205393 + - PATHOGENIC .98503 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Glu1092Ter ENST00000454757.6:c.3274G>T 7:g.55205393G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-97-8172-01 2194801 2063079 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51850921 COSM5982763 132561904 c.1744G>T p.G582* Substitution - Nonsense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 417 NS NS 75 ENSP00000395243.3:p.Gly582Ter ENST00000454757.6:c.1744G>T 7:g.55165436G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BR-8487-01 2197875 2066153 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51803089 COSM3266657 132568762 c.3067C>T p.R1023* Substitution - Nonsense 38 7:55202556-55202556 + - PATHOGENIC .90676 Confirmed somatic variant 541 NS NS 64 ENSP00000395243.3:p.Arg1023Ter ENST00000454757.6:c.3067C>T 7:g.55202556C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CC25 2766419 2624638 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51812193 COSM1090883 132553243 c.1870C>T p.R624* Substitution - Nonsense 38 7:55173068-55173068 + - PATHOGENIC .96775 Confirmed somatic variant 29844865 surgery fresh/frozen NS 61 ENSP00000395243.3:p.Arg624Ter ENST00000454757.6:c.1870C>T 7:g.55173068C>T FYB1_ENST00000646045 ENST00000646045.1 2520 4036 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105917563 COSM10012955 176310997 c.133A>T p.R45* Substitution - Nonsense 38 5:39202858-39202858 - - PATHOGENIC .9276 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000493623.1:p.Arg45Ter ENST00000646045.1:c.133A>T 5:g.39202858T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FG-A70Z-01 2194226 2062504 central_nervous_system brain NS NS glioma NS NS NS y COSV99289491 COSM8266379 132551799 c.3292C>T p.Q1098* Substitution - Nonsense 38 7:55205411-55205411 + - .60034 Confirmed somatic variant 545 NS NS 53 ENSP00000395243.3:p.Gln1098Ter ENST00000454757.6:c.3292C>T 7:g.55205411C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-97-8172-01 2194801 2063079 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51850921 COSM5982763 133218140 c.1744G>T p.G582* Substitution - Nonsense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 417 NS NS 75 ENSP00000415559.1:p.Gly582Ter ENST00000455089.5:c.1744G>T 7:g.55165436G>T EGFR ENST00000275493.6 3633 3236 P-0005212-T01-IM5 2721616 2580437 upper_aerodigestive_tract pharynx oropharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51859204 COSM6941837 99388455 c.3409G>T p.E1137* Substitution - Nonsense het 38 7:55205393-55205393 + - PATHOGENIC .98503 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Glu1137Ter ENST00000275493.6:c.3409G>T 7:g.55205393G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KM12 1998451 1883523 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51772793 COSM1673192 132551625 c.1582G>T p.G528* Substitution - Nonsense het 38 7:55163818-55163818 + - PATHOGENIC .99807 Confirmed somatic variant 23856246 cell-line primary ENSP00000395243.3:p.Gly528Ter ENST00000454757.6:c.1582G>T 7:g.55163818G>T EGFR ENST00000275493.6 3633 3236 TCGA-97-8172-01 2194801 2063079 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51850921 COSM5982763 99390462 c.1879G>T p.G627* Substitution - Nonsense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 417 NS NS 75 ENSP00000275493.2:p.Gly627Ter ENST00000275493.6:c.1879G>T 7:g.55165436G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BR-8487-01 2197875 2066153 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51803089 COSM3266657 133225916 c.3067C>T p.R1023* Substitution - Nonsense 38 7:55202556-55202556 + - PATHOGENIC .90676 Confirmed somatic variant 541 NS NS 64 ENSP00000415559.1:p.Arg1023Ter ENST00000455089.5:c.3067C>T 7:g.55202556C>T EGFR ENST00000275493.6 3633 3236 TCGA-BR-8487-01 2197875 2066153 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51803089 COSM3266657 99400643 c.3202C>T p.R1068* Substitution - Nonsense 38 7:55202556-55202556 + - PATHOGENIC .90676 Confirmed somatic variant 541 NS NS 64 ENSP00000275493.2:p.Arg1068Ter ENST00000275493.6:c.3202C>T 7:g.55202556C>T CR1 ENST00000367049.8 7470 2334 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65455967 COSM301989 110387692 c.6580C>T p.R2194* Substitution - Nonsense 38 1:207614408-207614408 + - NEUTRAL .07353 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000356016.4:p.Arg2194Ter ENST00000367049.8:c.6580C>T 1:g.207614408C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CC25 2766419 2624638 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51812193 COSM1090883 133208308 c.1870C>T p.R624* Substitution - Nonsense 38 7:55173068-55173068 + - PATHOGENIC .96775 Confirmed somatic variant 29844865 surgery fresh/frozen NS 61 ENSP00000415559.1:p.Arg624Ter ENST00000455089.5:c.1870C>T 7:g.55173068C>T EGFR ENST00000275493.6 3633 3236 CC25 2766419 2624638 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51812193 COSM1090883 99380122 c.2005C>T p.R669* Substitution - Nonsense 38 7:55173068-55173068 + - PATHOGENIC .96775 Confirmed somatic variant 29844865 surgery fresh/frozen NS 61 ENSP00000275493.2:p.Arg669Ter ENST00000275493.6:c.2005C>T 7:g.55173068C>T CR1 ENST00000367049.8 7470 2334 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65455974 COSM341835 110387952 c.6658G>T p.E2220* Substitution - Nonsense 38 1:207614486-207614486 + - PATHOGENIC .82817 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000356016.4:p.Glu2220Ter ENST00000367049.8:c.6658G>T 1:g.207614486G>T EGFR ENST00000275493.6 3633 3236 TCGA-FG-A70Z-01 2194226 2062504 central_nervous_system brain NS NS glioma NS NS NS y COSV99289491 COSM8266379 99378627 c.3427C>T p.Q1143* Substitution - Nonsense 38 7:55205411-55205411 + - .60034 Confirmed somatic variant 545 NS NS 53 ENSP00000275493.2:p.Gln1143Ter ENST00000275493.6:c.3427C>T 7:g.55205411C>T EGFR ENST00000275493.6 3633 3236 TCGA-EB-A4XL-01 2197820 2066098 skin NS NS NS malignant_melanoma NS NS NS y COSV51801770 COSM3923816 99394905 c.2944C>T p.Q982* Substitution - Nonsense 38 7:55200411-55200411 + - PATHOGENIC .98929 Confirmed somatic variant 540 NS NS 56 ENSP00000275493.2:p.Gln982Ter ENST00000275493.6:c.2944C>T 7:g.55200411C>T VPS13A_ENST00000357409 ENST00000357409.9 9288 1908 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105908792 COSM10012972 111516840 c.2191C>T p.R731* Substitution - Nonsense 38 9:77252255-77252255 + - PATHOGENIC .96696 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000349985.5:p.Arg731Ter ENST00000357409.9:c.2191C>T 9:g.77252255C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EB-A4XL-01 2197820 2066098 skin NS NS NS malignant_melanoma NS NS NS y COSV51801770 COSM3923816 132565115 c.2809C>T p.Q937* Substitution - Nonsense 38 7:55200411-55200411 + - PATHOGENIC .98929 Confirmed somatic variant 540 NS NS 56 ENSP00000395243.3:p.Gln937Ter ENST00000454757.6:c.2809C>T 7:g.55200411C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KM12 1998451 1883523 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51772793 COSM1673192 133206559 c.1582G>T p.G528* Substitution - Nonsense het 38 7:55163818-55163818 + - PATHOGENIC .99807 Confirmed somatic variant 23856246 cell-line primary ENSP00000415559.1:p.Gly528Ter ENST00000455089.5:c.1582G>T 7:g.55163818G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-GN-A8LK-06 2340243 2205226 skin NS NS NS malignant_melanoma NS NS NS y COSV99285707 COSM7957241 132602643 c.3403G>T p.E1135* Substitution - Nonsense 38 7:55205522-55205522 + - PATHOGENIC .93647 Confirmed somatic variant 540 NS NS 70 ENSP00000395243.3:p.Glu1135Ter ENST00000454757.6:c.3403G>T 7:g.55205522G>T EGFR ENST00000275493.6 3633 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801770 COSM3923816 99394905 c.2944C>T p.Q982* Substitution - Nonsense 38 7:55200411-55200411 + - PATHOGENIC .98929 Confirmed somatic variant 540 NS NS 68 ENSP00000275493.2:p.Gln982Ter ENST00000275493.6:c.2944C>T 7:g.55200411C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801770 COSM3923816 132565115 c.2809C>T p.Q937* Substitution - Nonsense 38 7:55200411-55200411 + - PATHOGENIC .98929 Confirmed somatic variant 540 NS NS 68 ENSP00000395243.3:p.Gln937Ter ENST00000454757.6:c.2809C>T 7:g.55200411C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006754-T01-IM5 2723133 2581954 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51850302 COSM6005744 132562276 c.1606C>T p.Q536* Substitution - Nonsense het 38 7:55165298-55165298 + - NEUTRAL .15904 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Gln536Ter ENST00000454757.6:c.1606C>T 7:g.55165298C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 YUROG 2439363 2302204 skin NS NS NS malignant_melanoma NS NS NS y COSV51803180 COSM5407716 132612969 c.487C>T p.Q163* Substitution - Nonsense het 38 7:55151356-55151356 + - PATHOGENIC .99214 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 58 ENSP00000395243.3:p.Gln163Ter ENST00000454757.6:c.487C>T 7:g.55151356C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AG-3881-01 1651557 1566344 large_intestine rectum NS NS NS NS NS NS y COSV99292247 COSM7522737 132585028 c.880G>T p.G294* Substitution - Nonsense 38 7:55156541-55156541 + - PATHOGENIC .99616 Confirmed somatic variant 375 NS primary 83 ENSP00000395243.3:p.Gly294Ter ENST00000454757.6:c.880G>T 7:g.55156541G>T EGFR ENST00000275493.6 3633 3236 YUROG 2439363 2302204 skin NS NS NS malignant_melanoma NS NS NS y COSV51803180 COSM5407716 99453270 c.622C>T p.Q208* Substitution - Nonsense het 38 7:55151356-55151356 + - PATHOGENIC .99214 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 58 ENSP00000275493.2:p.Gln208Ter ENST00000275493.6:c.622C>T 7:g.55151356C>T EGFR ENST00000275493.6 3633 3236 TCGA-GN-A8LK-06 2340243 2205226 skin NS NS NS malignant_melanoma NS NS NS y COSV99285707 COSM7957241 99443514 c.3538G>T p.E1180* Substitution - Nonsense 38 7:55205522-55205522 + - PATHOGENIC .93647 Confirmed somatic variant 540 NS NS 70 ENSP00000275493.2:p.Glu1180Ter ENST00000275493.6:c.3538G>T 7:g.55205522G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006754-T01-IM5 2723133 2581954 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51850302 COSM6005744 133218541 c.1606C>T p.Q536* Substitution - Nonsense het 38 7:55165298-55165298 + - NEUTRAL .15904 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Gln536Ter ENST00000455089.5:c.1606C>T 7:g.55165298C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0211-02 2120254 1994490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51804002 COSM3412186 132588850 c.691C>T p.Q231* Substitution - Nonsense 38 7:55154089-55154089 + - PATHOGENIC .94288 Confirmed somatic variant 329 NS NS 48 ENSP00000395243.3:p.Gln231Ter ENST00000454757.6:c.691C>T 7:g.55154089C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010671-T01-IM5 2726358 2585179 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51863439 COSM6975997 132598244 c.2323C>T p.Q775* Substitution - Nonsense het 38 7:55181467-55181467 + - PATHOGENIC .97193 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gln775Ter ENST00000454757.6:c.2323C>T 7:g.55181467C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-EB-A4XL-01 2197820 2066098 skin NS NS NS malignant_melanoma NS NS NS y COSV51801770 COSM3923816 133221538 c.2809C>T p.Q937* Substitution - Nonsense 38 7:55200411-55200411 + - PATHOGENIC .98929 Confirmed somatic variant 540 NS NS 56 ENSP00000415559.1:p.Gln937Ter ENST00000455089.5:c.2809C>T 7:g.55200411C>T EGFR ENST00000275493.6 3633 3236 P-0006754-T01-IM5 2723133 2581954 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51850302 COSM6005744 99390882 c.1741C>T p.Q581* Substitution - Nonsense het 38 7:55165298-55165298 + - NEUTRAL .15904 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Gln581Ter ENST00000275493.6:c.1741C>T 7:g.55165298C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2807190 2807190 2663894 testis NS NS NS germ_cell_tumour mixed NS NS n COSV99296857 COSM9118852 132614288 c.2581G>T p.E861* Substitution - Nonsense 38 7:55198731-55198731 + - PATHOGENIC .9948 Confirmed somatic variant 27018785 surgery-fixed metastasis ENSP00000395243.3:p.Glu861Ter ENST00000454757.6:c.2581G>T 7:g.55198731G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-B5-A11E-01 1783399 1687398 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51772740 COSM3881824 132569891 c.1456C>T p.R486* Substitution - Nonsense 38 7:55161591-55161591 + - PATHOGENIC .9543 Confirmed somatic variant 419 fresh/frozen - NOS primary 53 ENSP00000395243.3:p.Arg486Ter ENST00000454757.6:c.1456C>T 7:g.55161591C>T EGFR ENST00000275493.6 3633 3236 KM12 1998451 1883523 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51772793 COSM1673192 99378463 c.1717G>T p.G573* Substitution - Nonsense het 38 7:55163818-55163818 + - PATHOGENIC .99807 Confirmed somatic variant 23856246 cell-line primary ENSP00000275493.2:p.Gly573Ter ENST00000275493.6:c.1717G>T 7:g.55163818G>T EGFR ENST00000275493.6 3633 3236 TCGA-P3-A6T5-01 2193575 2061853 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99286603 COSM8273399 99379139 c.2654C>G p.S885* Substitution - Nonsense 38 7:55192794-55192794 + - PATHOGENIC .95834 Confirmed somatic variant 627 NS NS 79 ENSP00000275493.2:p.Ser885Ter ENST00000275493.6:c.2654C>G 7:g.55192794C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 YUROG 2439363 2302204 skin NS NS NS malignant_melanoma NS NS NS y COSV51803180 COSM5407716 133277041 c.487C>T p.Q163* Substitution - Nonsense het 38 7:55151356-55151356 + - PATHOGENIC .99214 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 58 ENSP00000415559.1:p.Gln163Ter ENST00000455089.5:c.487C>T 7:g.55151356C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801770 COSM3923816 133221538 c.2809C>T p.Q937* Substitution - Nonsense 38 7:55200411-55200411 + - PATHOGENIC .98929 Confirmed somatic variant 540 NS NS 68 ENSP00000415559.1:p.Gln937Ter ENST00000455089.5:c.2809C>T 7:g.55200411C>T EGFR ENST00000275493.6 3633 3236 TCGA-06-0211-02 2120254 1994490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51804002 COSM3412186 99427063 c.826C>T p.Q276* Substitution - Nonsense 38 7:55154089-55154089 + - PATHOGENIC .94288 Confirmed somatic variant 329 NS NS 48 ENSP00000275493.2:p.Gln276Ter ENST00000275493.6:c.826C>T 7:g.55154089C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2807190 2807190 2663894 testis NS NS NS germ_cell_tumour mixed NS NS n COSV99296857 COSM9118852 133278351 c.2581G>T p.E861* Substitution - Nonsense 38 7:55198731-55198731 + - PATHOGENIC .9948 Confirmed somatic variant 27018785 surgery-fixed metastasis ENSP00000415559.1:p.Glu861Ter ENST00000455089.5:c.2581G>T 7:g.55198731G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-P3-A6T5-01 2193575 2061853 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99286603 COSM8273399 133207276 c.2519C>G p.S840* Substitution - Nonsense 38 7:55192794-55192794 + - PATHOGENIC .95834 Confirmed somatic variant 627 NS NS 79 ENSP00000415559.1:p.Ser840Ter ENST00000455089.5:c.2519C>G 7:g.55192794C>G EGFR ENST00000275493.6 3633 3236 TCGA-AG-3881-01 1651557 1566344 large_intestine rectum NS NS NS NS NS NS y COSV99292247 COSM7522737 99421713 c.1015G>T p.G339* Substitution - Nonsense 38 7:55156541-55156541 + - PATHOGENIC .99616 Confirmed somatic variant 375 NS primary 83 ENSP00000275493.2:p.Gly339Ter ENST00000275493.6:c.1015G>T 7:g.55156541G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-P3-A6T5-01 2193575 2061853 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99286603 COSM8273399 132552308 c.2519C>G p.S840* Substitution - Nonsense 38 7:55192794-55192794 + - PATHOGENIC .95834 Confirmed somatic variant 627 NS NS 79 ENSP00000395243.3:p.Ser840Ter ENST00000454757.6:c.2519C>G 7:g.55192794C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-B5-A1MX-01 2198273 2066551 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51772793 COSM1673192 132551625 c.1582G>T p.G528* Substitution - Nonsense 38 7:55163818-55163818 + - PATHOGENIC .99807 Confirmed somatic variant 419 NS NS 47 ENSP00000395243.3:p.Gly528Ter ENST00000454757.6:c.1582G>T 7:g.55163818G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EXTERN_MELA_20140524_014 2839451 2695217 skin scalp NS NS malignant_melanoma NS NS NS y COSV104576316 COSM9447511 132615546 c.2718G>A p.W906* Substitution - Nonsense 38 7:55200320-55200320 + - PATHOGENIC .99504 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000395243.3:p.Trp906Ter ENST00000454757.6:c.2718G>A 7:g.55200320G>A EGFR ENST00000275493.6 3633 3236 CC25 2856036 2711437 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSM9516326 178389661 c.? p.R669* Substitution - Nonsense + - Confirmed somatic variant 29665843 surgery fresh/frozen NS 61 ENSP00000275493.2:p.Arg669Ter EGFR ENST00000275493.6 3633 3236 TCGA-B5-A11E-01 1783399 1687398 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51772740 COSM3881824 99401861 c.1591C>T p.R531* Substitution - Nonsense 38 7:55161591-55161591 + - PATHOGENIC .9543 Confirmed somatic variant 419 fresh/frozen - NOS primary 53 ENSP00000275493.2:p.Arg531Ter ENST00000275493.6:c.1591C>T 7:g.55161591C>T EGFR ENST00000275493.6 3633 3236 2807190 2807190 2663894 testis NS NS NS germ_cell_tumour mixed NS NS n COSV99296857 COSM9118852 99454540 c.2716G>T p.E906* Substitution - Nonsense 38 7:55198731-55198731 + - PATHOGENIC .9948 Confirmed somatic variant 27018785 surgery-fixed metastasis ENSP00000275493.2:p.Glu906Ter ENST00000275493.6:c.2716G>T 7:g.55198731G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0211-02 2120254 1994490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51804002 COSM3412186 133250548 c.691C>T p.Q231* Substitution - Nonsense 38 7:55154089-55154089 + - PATHOGENIC .94288 Confirmed somatic variant 329 NS NS 48 ENSP00000415559.1:p.Gln231Ter ENST00000455089.5:c.691C>T 7:g.55154089C>T EGFR ENST00000275493.6 3633 3236 6481_CLM 2500985 2363336 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51805522 COSM5757058 99388345 c.1431G>A p.W477* Substitution - Nonsense 38 7:55160271-55160271 + - PATHOGENIC .98844 Confirmed somatic variant 26109429 fresh/frozen - NOS metastasis 60 ENSP00000275493.2:p.Trp477Ter ENST00000275493.6:c.1431G>A 7:g.55160271G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 6481_CLM 2500985 2363336 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51805522 COSM5757058 132560308 c.1296G>A p.W432* Substitution - Nonsense 38 7:55160271-55160271 + - PATHOGENIC .98844 Confirmed somatic variant 26109429 fresh/frozen - NOS metastasis 60 ENSP00000395243.3:p.Trp432Ter ENST00000454757.6:c.1296G>A 7:g.55160271G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-B5-A11E-01 1783399 1687398 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51772740 COSM3881824 133227409 c.1456C>T p.R486* Substitution - Nonsense 38 7:55161591-55161591 + - PATHOGENIC .9543 Confirmed somatic variant 419 fresh/frozen - NOS primary 53 ENSP00000415559.1:p.Arg486Ter ENST00000455089.5:c.1456C>T 7:g.55161591C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AG-3881-01 1651557 1566344 large_intestine rectum NS NS NS NS NS NS y COSV99292247 COSM7522737 133246377 c.880G>T p.G294* Substitution - Nonsense 38 7:55156541-55156541 + - PATHOGENIC .99616 Confirmed somatic variant 375 NS primary 83 ENSP00000415559.1:p.Gly294Ter ENST00000455089.5:c.880G>T 7:g.55156541G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GC_315T-GC_315N 2324594 2189703 stomach NS NS NS carcinoma diffuse_adenocarcinoma NS NS y COSV51812362 COSM4773811 132556444 c.464G>A p.W155* Substitution - Nonsense 38 7:55151333-55151333 + - PATHOGENIC .99472 Confirmed somatic variant 24816255 surgery fresh/frozen NS ENSP00000395243.3:p.Trp155Ter ENST00000454757.6:c.464G>A 7:g.55151333G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-B5-A1MX-01 2198273 2066551 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51772793 COSM1673192 133206559 c.1582G>T p.G528* Substitution - Nonsense 38 7:55163818-55163818 + - PATHOGENIC .99807 Confirmed somatic variant 419 NS NS 47 ENSP00000415559.1:p.Gly528Ter ENST00000455089.5:c.1582G>T 7:g.55163818G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010671-T01-IM5 2726358 2585179 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51863439 COSM6975997 133262029 c.2323C>T p.Q775* Substitution - Nonsense het 38 7:55181467-55181467 + - PATHOGENIC .97193 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gln775Ter ENST00000455089.5:c.2323C>T 7:g.55181467C>T EGFR ENST00000275493.6 3633 3236 P-0010671-T01-IM5 2726358 2585179 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51863439 COSM6975997 99439031 c.2458C>T p.Q820* Substitution - Nonsense het 38 7:55181467-55181467 + - PATHOGENIC .97193 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gln820Ter ENST00000275493.6:c.2458C>T 7:g.55181467C>T EGFR ENST00000275493.6 3633 3236 GC_315T-GC_315N 2324594 2189703 stomach NS NS NS carcinoma diffuse_adenocarcinoma NS NS y COSV51812362 COSM4773811 99383844 c.599G>A p.W200* Substitution - Nonsense 38 7:55151333-55151333 + - PATHOGENIC .99472 Confirmed somatic variant 24816255 surgery fresh/frozen NS ENSP00000275493.2:p.Trp200Ter ENST00000275493.6:c.599G>A 7:g.55151333G>A EGFR ENST00000275493.6 3633 3236 EXTERN_MELA_20140524_014 2839451 2695217 skin scalp NS NS malignant_melanoma NS NS NS y COSV104576316 COSM9447511 99455312 c.2853G>A p.W951* Substitution - Nonsense 38 7:55200320-55200320 + - PATHOGENIC .99504 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000275493.2:p.Trp951Ter ENST00000275493.6:c.2853G>A 7:g.55200320G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EXTERN_MELA_20140524_014 2839451 2695217 skin scalp NS NS malignant_melanoma NS NS NS y COSV104576316 COSM9447511 133279277 c.2718G>A p.W906* Substitution - Nonsense 38 7:55200320-55200320 + - PATHOGENIC .99504 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000415559.1:p.Trp906Ter ENST00000455089.5:c.2718G>A 7:g.55200320G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-CG-5726-01 2198104 2066382 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51772740 COSM3881824 132569891 c.1456C>T p.R486* Substitution - Nonsense 38 7:55161591-55161591 + - PATHOGENIC .9543 Confirmed somatic variant 541 NS NS 73 ENSP00000395243.3:p.Arg486Ter ENST00000454757.6:c.1456C>T 7:g.55161591C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 6481_CLM 2500985 2363336 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51805522 COSM5757058 133216381 c.1296G>A p.W432* Substitution - Nonsense 38 7:55160271-55160271 + - PATHOGENIC .98844 Confirmed somatic variant 26109429 fresh/frozen - NOS metastasis 60 ENSP00000415559.1:p.Trp432Ter ENST00000455089.5:c.1296G>A 7:g.55160271G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GC_315T-GC_315N 2324594 2189703 stomach NS NS NS carcinoma diffuse_adenocarcinoma NS NS y COSV51812362 COSM4773811 133212444 c.464G>A p.W155* Substitution - Nonsense 38 7:55151333-55151333 + - PATHOGENIC .99472 Confirmed somatic variant 24816255 surgery fresh/frozen NS ENSP00000415559.1:p.Trp155Ter ENST00000455089.5:c.464G>A 7:g.55151333G>A EGFR ENST00000275493.6 3633 3236 TCGA-B5-A1MX-01 2198273 2066551 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51772793 COSM1673192 99378463 c.1717G>T p.G573* Substitution - Nonsense 38 7:55163818-55163818 + - PATHOGENIC .99807 Confirmed somatic variant 419 NS NS 47 ENSP00000275493.2:p.Gly573Ter ENST00000275493.6:c.1717G>T 7:g.55163818G>T EGFR ENST00000275493.6 3633 3236 TCGA-CG-5726-01 2198104 2066382 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51772740 COSM3881824 99401861 c.1591C>T p.R531* Substitution - Nonsense 38 7:55161591-55161591 + - PATHOGENIC .9543 Confirmed somatic variant 541 NS NS 73 ENSP00000275493.2:p.Arg531Ter ENST00000275493.6:c.1591C>T 7:g.55161591C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-46-3765-01 1781761 1685760 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51850921 COSM5982763 132561904 c.1744G>T p.G582* Substitution - Nonsense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 418 fresh/frozen - NOS primary 59 ENSP00000395243.3:p.Gly582Ter ENST00000454757.6:c.1744G>T 7:g.55165436G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EA-A6QX-01 2193366 2061644 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51766890 COSM13432 132557859 c.2058G>A p.W686* Substitution - Nonsense 38 7:55174730-55174730 + - PATHOGENIC .99879 Confirmed somatic variant 415 NS NS 49 ENSP00000395243.3:p.Trp686Ter ENST00000454757.6:c.2058G>A 7:g.55174730G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-CG-5726-01 2198104 2066382 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51772740 COSM3881824 133227409 c.1456C>T p.R486* Substitution - Nonsense 38 7:55161591-55161591 + - PATHOGENIC .9543 Confirmed somatic variant 541 NS NS 73 ENSP00000415559.1:p.Arg486Ter ENST00000455089.5:c.1456C>T 7:g.55161591C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 10-428 1960462 1847022 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51833036 COSM1645315 132561785 c.798T>A p.C266* Substitution - Nonsense het 38 7:55155873-55155873 + - NEUTRAL .23167 Confirmed somatic variant 23700467 fresh/frozen - NOS primary ENSP00000395243.3:p.Cys266Ter ENST00000454757.6:c.798T>A 7:g.55155873T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-D3-A51R-06 2121547 1995783 skin NS NS NS malignant_melanoma NS NS NS y COSV99289214 COSM7930339 133261350 c.3143G>A p.W1048* Substitution - Nonsense 38 7:55202632-55202632 + - NEUTRAL .06513 Confirmed somatic variant 540 NS NS 60 ENSP00000415559.1:p.Trp1048Ter ENST00000455089.5:c.3143G>A 7:g.55202632G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0014573-T01-IM6 2830595 2686410 breast NS NS NS carcinoma ductolobular_carcinoma NS NS n COSV104577192 COSM9359618 132580754 c.1638C>A p.C546* Substitution - Nonsense 38 7:55165330-55165330 + - NEUTRAL .48246 Confirmed somatic variant 30205045 surgery-fixed primary 68 ENSP00000395243.3:p.Cys546Ter ENST00000454757.6:c.1638C>A 7:g.55165330C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 23 2699404 2558308 skin NS NS NS malignant_melanoma NS NS NS n COSV51774325 COSM6906388 132560545 c.2350G>T p.E784* Substitution - Nonsense het 38 7:55191734-55191734 + - PATHOGENIC .9903 Confirmed somatic variant 29420467 surgery-fixed NS ENSP00000395243.3:p.Glu784Ter ENST00000454757.6:c.2350G>T 7:g.55191734G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SJG-018 2561465 2422889 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS y COSV51850921 COSM5982763 132561904 c.1744G>T p.G582* Substitution - Nonsense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 27693639 short-term culture primary 79 ENSP00000395243.3:p.Gly582Ter ENST00000454757.6:c.1744G>T 7:g.55165436G>T EGFR ENST00000275493.6 3633 3236 23 2699404 2558308 skin NS NS NS malignant_melanoma NS NS NS n COSV51774325 COSM6906388 99388654 c.2485G>T p.E829* Substitution - Nonsense het 38 7:55191734-55191734 + - PATHOGENIC .9903 Confirmed somatic variant 29420467 surgery-fixed NS ENSP00000275493.2:p.Glu829Ter ENST00000275493.6:c.2485G>T 7:g.55191734G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007076-T03-IM5 2723450 2582271 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS n COSV51860976 COSM6961894 132620955 c.2504G>A p.W835* Substitution - Nonsense het 38 7:55192779-55192779 + - PATHOGENIC .96551 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Trp835Ter ENST00000454757.6:c.2504G>A 7:g.55192779G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-46-3765-01 1781761 1685760 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51850921 COSM5982763 133218140 c.1744G>T p.G582* Substitution - Nonsense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 418 fresh/frozen - NOS primary 59 ENSP00000415559.1:p.Gly582Ter ENST00000455089.5:c.1744G>T 7:g.55165436G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006952-T01-IM5 2723330 2582151 skin NS NS NS malignant_melanoma NS NS NS n COSV51774325 COSM6906388 132560545 c.2350G>T p.E784* Substitution - Nonsense het 38 7:55191734-55191734 + - PATHOGENIC .9903 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Glu784Ter ENST00000454757.6:c.2350G>T 7:g.55191734G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0014573-T01-IM6 2830595 2686410 breast NS NS NS carcinoma ductolobular_carcinoma NS NS n COSV104577192 COSM9359618 133241866 c.1638C>A p.C546* Substitution - Nonsense 38 7:55165330-55165330 + - NEUTRAL .48246 Confirmed somatic variant 30205045 surgery-fixed primary 68 ENSP00000415559.1:p.Cys546Ter ENST00000455089.5:c.1638C>A 7:g.55165330C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 23 2699404 2558308 skin NS NS NS malignant_melanoma NS NS NS n COSV51774325 COSM6906388 133216606 c.2350G>T p.E784* Substitution - Nonsense het 38 7:55191734-55191734 + - PATHOGENIC .9903 Confirmed somatic variant 29420467 surgery-fixed NS ENSP00000415559.1:p.Glu784Ter ENST00000455089.5:c.2350G>T 7:g.55191734G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SJG-018 2561465 2422889 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS y COSV51850921 COSM5982763 133218140 c.1744G>T p.G582* Substitution - Nonsense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 27693639 short-term culture primary 79 ENSP00000415559.1:p.Gly582Ter ENST00000455089.5:c.1744G>T 7:g.55165436G>T EGFR ENST00000275493.6 3633 3236 P-0006952-T01-IM5 2723330 2582151 skin NS NS NS malignant_melanoma NS NS NS n COSV51774325 COSM6906388 99388654 c.2485G>T p.E829* Substitution - Nonsense het 38 7:55191734-55191734 + - PATHOGENIC .9903 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Glu829Ter ENST00000275493.6:c.2485G>T 7:g.55191734G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-EA-A6QX-01 2193366 2061644 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51766890 COSM13432 133213936 c.2058G>A p.W686* Substitution - Nonsense 38 7:55174730-55174730 + - PATHOGENIC .99879 Confirmed somatic variant 415 NS NS 49 ENSP00000415559.1:p.Trp686Ter ENST00000455089.5:c.2058G>A 7:g.55174730G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-HT-8104-01 2194218 2062496 central_nervous_system brain NS NS glioma NS NS NS y COSV51806395 COSM3929122 132592473 c.2505G>A p.W835* Substitution - Nonsense 38 7:55192780-55192780 + - PATHOGENIC .96551 Confirmed somatic variant 545 NS NS 51 ENSP00000395243.3:p.Trp835Ter ENST00000454757.6:c.2505G>A 7:g.55192780G>A EGFR ENST00000275493.6 3633 3236 TCGA-46-3765-01 1781761 1685760 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51850921 COSM5982763 99390462 c.1879G>T p.G627* Substitution - Nonsense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 418 fresh/frozen - NOS primary 59 ENSP00000275493.2:p.Gly627Ter ENST00000275493.6:c.1879G>T 7:g.55165436G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CPCG0592-F1 2746222 2604925 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51811586 COSM7327079 132550806 c.2782C>T p.R928* Substitution - Nonsense 38 7:55200384-55200384 + - PATHOGENIC .95902 Confirmed somatic variant 537 NS primary 66 ENSP00000395243.3:p.Arg928Ter ENST00000454757.6:c.2782C>T 7:g.55200384C>T EGFR ENST00000275493.6 3633 3236 P-0014573-T01-IM6 2830595 2686410 breast NS NS NS carcinoma ductolobular_carcinoma NS NS n COSV104577192 COSM9359618 99416178 c.1773C>A p.C591* Substitution - Nonsense 38 7:55165330-55165330 + - NEUTRAL .48246 Confirmed somatic variant 30205045 surgery-fixed primary 68 ENSP00000275493.2:p.Cys591Ter ENST00000275493.6:c.1773C>A 7:g.55165330C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 10-428 1960462 1847022 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51833036 COSM1645315 133217994 c.798T>A p.C266* Substitution - Nonsense het 38 7:55155873-55155873 + - NEUTRAL .23167 Confirmed somatic variant 23700467 fresh/frozen - NOS primary ENSP00000415559.1:p.Cys266Ter ENST00000455089.5:c.798T>A 7:g.55155873T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-D3-A8GI-06 2263025 2130009 skin NS NS NS malignant_melanoma NS NS NS y COSV51850302 COSM6005744 132562276 c.1606C>T p.Q536* Substitution - Nonsense 38 7:55165298-55165298 + - NEUTRAL .15904 Confirmed somatic variant 540 NS NS 68 ENSP00000395243.3:p.Gln536Ter ENST00000454757.6:c.1606C>T 7:g.55165298C>T EGFR ENST00000275493.6 3633 3236 TCGA-EA-A6QX-01 2193366 2061644 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51766890 COSM13432 99385450 c.2193G>A p.W731* Substitution - Nonsense 38 7:55174730-55174730 + - PATHOGENIC .99879 Confirmed somatic variant 415 NS NS 49 ENSP00000275493.2:p.Trp731Ter ENST00000275493.6:c.2193G>A 7:g.55174730G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006952-T01-IM5 2723330 2582151 skin NS NS NS malignant_melanoma NS NS NS n COSV51774325 COSM6906388 133216606 c.2350G>T p.E784* Substitution - Nonsense het 38 7:55191734-55191734 + - PATHOGENIC .9903 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Glu784Ter ENST00000455089.5:c.2350G>T 7:g.55191734G>T EGFR ENST00000275493.6 3633 3236 10-428 1960462 1847022 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51833036 COSM1645315 99390309 c.933T>A p.C311* Substitution - Nonsense het 38 7:55155873-55155873 + - NEUTRAL .23167 Confirmed somatic variant 23700467 fresh/frozen - NOS primary ENSP00000275493.2:p.Cys311Ter ENST00000275493.6:c.933T>A 7:g.55155873T>A EGFR ENST00000275493.6 3633 3236 P-0007076-T03-IM5 2723450 2582271 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS n COSV51860976 COSM6961894 99459632 c.2639G>A p.W880* Substitution - Nonsense het 38 7:55192779-55192779 + - PATHOGENIC .96551 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Trp880Ter ENST00000275493.6:c.2639G>A 7:g.55192779G>A EGFR ENST00000275493.6 3633 3236 SJG-018 2561465 2422889 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS y COSV51850921 COSM5982763 99390462 c.1879G>T p.G627* Substitution - Nonsense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 27693639 short-term culture primary 79 ENSP00000275493.2:p.Gly627Ter ENST00000275493.6:c.1879G>T 7:g.55165436G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007076-T03-IM5 2723450 2582271 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS n COSV51860976 COSM6961894 133284127 c.2504G>A p.W835* Substitution - Nonsense het 38 7:55192779-55192779 + - PATHOGENIC .96551 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Trp835Ter ENST00000455089.5:c.2504G>A 7:g.55192779G>A EGFR ENST00000275493.6 3633 3236 TCGA-HT-8104-01 2194218 2062496 central_nervous_system brain NS NS glioma NS NS NS y COSV51806395 COSM3929122 99431750 c.2640G>A p.W880* Substitution - Nonsense 38 7:55192780-55192780 + - PATHOGENIC .96551 Confirmed somatic variant 545 NS NS 51 ENSP00000275493.2:p.Trp880Ter ENST00000275493.6:c.2640G>A 7:g.55192780G>A EGFR ENST00000275493.6 3633 3236 1468613 1468613 1392364 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM53174 178383311 c.? p.W731* Substitution - Nonsense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Trp731Ter EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-HT-8104-01 2194218 2062496 central_nervous_system brain NS NS glioma NS NS NS y COSV51806395 COSM3929122 133255286 c.2505G>A p.W835* Substitution - Nonsense 38 7:55192780-55192780 + - PATHOGENIC .96551 Confirmed somatic variant 545 NS NS 51 ENSP00000415559.1:p.Trp835Ter ENST00000455089.5:c.2505G>A 7:g.55192780G>A EGFR ENST00000275493.6 3633 3236 TCGA-D3-A8GI-06 2263025 2130009 skin NS NS NS malignant_melanoma NS NS NS y COSV51850302 COSM6005744 99390882 c.1741C>T p.Q581* Substitution - Nonsense 38 7:55165298-55165298 + - NEUTRAL .15904 Confirmed somatic variant 540 NS NS 68 ENSP00000275493.2:p.Gln581Ter ENST00000275493.6:c.1741C>T 7:g.55165298C>T EGFR ENST00000275493.6 3633 3236 CC27 2856038 2711439 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSM53174 178383311 c.? p.W731* Substitution - Nonsense + - Confirmed somatic variant 29665843 surgery fresh/frozen NS 62 ENSP00000275493.2:p.Trp731Ter EGFR ENST00000275493.6 3633 3236 CPCG0592-F1 2746222 2604925 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51811586 COSM7327079 99377688 c.2917C>T p.R973* Substitution - Nonsense 38 7:55200384-55200384 + - PATHOGENIC .95902 Confirmed somatic variant 537 NS primary 66 ENSP00000275493.2:p.Arg973Ter ENST00000275493.6:c.2917C>T 7:g.55200384C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-D3-A8GI-06 2263025 2130009 skin NS NS NS malignant_melanoma NS NS NS y COSV51850302 COSM6005744 133218541 c.1606C>T p.Q536* Substitution - Nonsense 38 7:55165298-55165298 + - NEUTRAL .15904 Confirmed somatic variant 540 NS NS 68 ENSP00000415559.1:p.Gln536Ter ENST00000455089.5:c.1606C>T 7:g.55165298C>T FYB1_ENST00000515010 ENST00000515010.5 2352 4036 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105917563 COSM10012955 146404925 c.103A>T p.R35* Substitution - Nonsense 38 5:39202858-39202858 - - PATHOGENIC .9276 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000426346.1:p.Arg35Ter ENST00000515010.5:c.103A>T 5:g.39202858T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CPCG0592-F1 2746222 2604925 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51811586 COSM7327079 133205731 c.2782C>T p.R928* Substitution - Nonsense 38 7:55200384-55200384 + - PATHOGENIC .95902 Confirmed somatic variant 537 NS primary 66 ENSP00000415559.1:p.Arg928Ter ENST00000455089.5:c.2782C>T 7:g.55200384C>T B3GNT7 ENST00000287590.5 1206 18811 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV55006217 COSM5930826 101017925 c.12G>A p.W4* Substitution - Nonsense 38 2:231397731-231397731 + - PATHOGENIC .99165 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000287590.5:p.Trp4Ter ENST00000287590.5:c.12G>A 2:g.231397731G>A SYNE1_ENST00000341594 ENST00000341594.9 25179 17089 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105842737 COSM10012866 103121257 c.34C>T p.Q12* Substitution - Nonsense 38 6:152540004-152540004 - - PATHOGENIC .9583 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000341887.6:p.Gln12Ter ENST00000341594.9:c.34C>T 6:g.152540004G>A FAM131B_ENST00000409222 ENST00000409222.7 999 22202 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV58373157 COSM5872106 120136320 c.895C>T p.R299* Substitution - Nonsense 38 7:143356654-143356654 - - PATHOGENIC .82823 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000387147.3:p.Arg299Ter ENST00000409222.7:c.895C>T 7:g.143356654G>A FCGR3A ENST00000638849.1 873 3619 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV63459571 COSM530144 171972510 c.808C>T p.R270* Substitution - Nonsense 38 1:161543077-161543077 - - NEUTRAL .26854 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000491631.1:p.Arg270Ter ENST00000638849.1:c.808C>T 1:g.161543077G>A FCGR3A_ENST00000367969 ENST00000367969.8 1080 3619 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV63459571 COSM530144 109798791 c.1015C>T p.R339* Substitution - Nonsense 38 1:161543077-161543077 - - NEUTRAL .26854 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000356946.4:p.Arg339Ter ENST00000367969.8:c.1015C>T 1:g.161543077G>A SYNE1_ENST00000367248 ENST00000367248.7 4302 17089 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105842737 COSM10012866 111113843 c.85C>T p.Q29* Substitution - Nonsense 38 6:152540004-152540004 - - PATHOGENIC .9583 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000356217.3:p.Gln29Ter ENST00000367248.7:c.85C>T 6:g.152540004G>A VPS13A ENST00000360280.7 9525 1908 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105908792 COSM10012972 107883965 c.2191C>T p.R731* Substitution - Nonsense 38 9:77252255-77252255 + - PATHOGENIC .96696 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000353422.3:p.Arg731Ter ENST00000360280.7:c.2191C>T 9:g.77252255C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 C1981 2897773 2752072 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105863715 COSM9966014 174319467 c.927C>A p.C309* Substitution - Nonsense 38 7:55161545-55161545 + - PATHOGENIC .9683 Variant of unknown origin 31477716 surgery-fixed NS 47 ENSP00000492462.1:p.Cys309Ter ENST00000638463.1:c.927C>A 7:g.55161545C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-69-7765-01 1914039 1802321 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51790518 COSM6178052 174391429 c.838C>T p.Q280* Substitution - Nonsense 38 7:55160296-55160296 + - PATHOGENIC .99317 Variant of unknown origin 417 fresh/frozen - NOS primary 56 ENSP00000492462.1:p.Gln280Ter ENST00000638463.1:c.838C>T 7:g.55160296C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 BL-17-K13274 2905590 2759846 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864138 COSM9997840 174355350 c.685C>T p.Q229* Substitution - Nonsense 38 7:55160143-55160143 + - PATHOGENIC .9567 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000492462.1:p.Gln229Ter ENST00000638463.1:c.685C>T 7:g.55160143C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-BG-A0VZ-01 1783443 1687442 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51812193 COSM1090883 174324400 c.1387C>T p.R463* Substitution - Nonsense hom 38 7:55173068-55173068 + - PATHOGENIC .96775 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 58 ENSP00000492462.1:p.Arg463Ter ENST00000638463.1:c.1387C>T 7:g.55173068C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 KM12 2301990 2167273 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51772793 COSM1673192 174322191 c.1099G>T p.G367* Substitution - Nonsense het 38 7:55163818-55163818 + - PATHOGENIC .99807 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000492462.1:p.Gly367Ter ENST00000638463.1:c.1099G>T 7:g.55163818G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2579713 2579713 2441050 NS NS NS NS malignant_melanoma NS NS NS n COSV51850302 COSM6005744 174335280 c.1123C>T p.Q375* Substitution - Nonsense 38 7:55165298-55165298 + - NEUTRAL .15904 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000492462.1:p.Gln375Ter ENST00000638463.1:c.1123C>T 7:g.55165298C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 143 2748115 2606818 stomach NS NS NS carcinoma NS NS NS y COSV99286726 COSM8594240 174378712 c.580G>T p.E194* Substitution - Nonsense 38 7:55156823-55156823 + - PATHOGENIC .99626 Confirmed somatic variant 683 NS primary ENSP00000492462.1:p.Glu194Ter ENST00000638463.1:c.580G>T 7:g.55156823G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-97-8172-01 2194801 2063079 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51850921 COSM5982763 174334905 c.1261G>T p.G421* Substitution - Nonsense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 417 NS NS 75 ENSP00000492462.1:p.Gly421Ter ENST00000638463.1:c.1261G>T 7:g.55165436G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 CC25 2766419 2624638 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51812193 COSM1090883 174324400 c.1387C>T p.R463* Substitution - Nonsense 38 7:55173068-55173068 + - PATHOGENIC .96775 Confirmed somatic variant 29844865 surgery fresh/frozen NS 61 ENSP00000492462.1:p.Arg463Ter ENST00000638463.1:c.1387C>T 7:g.55173068C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 KM12 1998451 1883523 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51772793 COSM1673192 174322191 c.1099G>T p.G367* Substitution - Nonsense het 38 7:55163818-55163818 + - PATHOGENIC .99807 Confirmed somatic variant 23856246 cell-line primary ENSP00000492462.1:p.Gly367Ter ENST00000638463.1:c.1099G>T 7:g.55163818G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0211-02 2120254 1994490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51804002 COSM3412186 174365345 c.208C>T p.Q70* Substitution - Nonsense 38 7:55154089-55154089 + - PATHOGENIC .94288 Confirmed somatic variant 329 NS NS 48 ENSP00000492462.1:p.Gln70Ter ENST00000638463.1:c.208C>T 7:g.55154089C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0006754-T01-IM5 2723133 2581954 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51850302 COSM6005744 174335280 c.1123C>T p.Q375* Substitution - Nonsense het 38 7:55165298-55165298 + - NEUTRAL .15904 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Gln375Ter ENST00000638463.1:c.1123C>T 7:g.55165298C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-AG-3881-01 1651557 1566344 large_intestine rectum NS NS NS NS NS NS y COSV99292247 COSM7522737 174361695 c.397G>T p.G133* Substitution - Nonsense 38 7:55156541-55156541 + - PATHOGENIC .99616 Confirmed somatic variant 375 NS primary 83 ENSP00000492462.1:p.Gly133Ter ENST00000638463.1:c.397G>T 7:g.55156541G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-B5-A11E-01 1783399 1687398 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51772740 COSM3881824 174344517 c.973C>T p.R325* Substitution - Nonsense 38 7:55161591-55161591 + - PATHOGENIC .9543 Confirmed somatic variant 419 fresh/frozen - NOS primary 53 ENSP00000492462.1:p.Arg325Ter ENST00000638463.1:c.973C>T 7:g.55161591C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 6481_CLM 2500985 2363336 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51805522 COSM5757058 174333052 c.813G>A p.W271* Substitution - Nonsense 38 7:55160271-55160271 + - PATHOGENIC .98844 Confirmed somatic variant 26109429 fresh/frozen - NOS metastasis 60 ENSP00000492462.1:p.Trp271Ter ENST00000638463.1:c.813G>A 7:g.55160271G>A PCDHAC1 ENST00000253807.2 2892 8676 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV53858986 COSM6451919 97814954 c.2341C>T p.R781* Substitution - Nonsense 38 5:140929233-140929233 + - PATHOGENIC .91795 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000253807.2:p.Arg781Ter ENST00000253807.2:c.2341C>T 5:g.140929233C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-B5-A1MX-01 2198273 2066551 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51772793 COSM1673192 174322191 c.1099G>T p.G367* Substitution - Nonsense 38 7:55163818-55163818 + - PATHOGENIC .99807 Confirmed somatic variant 419 NS NS 47 ENSP00000492462.1:p.Gly367Ter ENST00000638463.1:c.1099G>T 7:g.55163818G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-CG-5726-01 2198104 2066382 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51772740 COSM3881824 174344517 c.973C>T p.R325* Substitution - Nonsense 38 7:55161591-55161591 + - PATHOGENIC .9543 Confirmed somatic variant 541 NS NS 73 ENSP00000492462.1:p.Arg325Ter ENST00000638463.1:c.973C>T 7:g.55161591C>T SYNE1_ENST00000413186 ENST00000413186.6 4332 17089 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105842737 COSM10012866 121699876 c.85C>T p.Q29* Substitution - Nonsense 38 6:152540004-152540004 - - PATHOGENIC .9583 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000414510.2:p.Gln29Ter ENST00000413186.6:c.85C>T 6:g.152540004G>A PCDHAC1_ENST00000409700 ENST00000409700.4 2457 8676 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV53858986 COSM6451919 123215603 c.2341C>T p.R781* Substitution - Nonsense 38 5:140929233-140929233 + - PATHOGENIC .91795 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000386356.3:p.Arg781Ter ENST00000409700.4:c.2341C>T 5:g.140929233C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0014573-T01-IM6 2830595 2686410 breast NS NS NS carcinoma ductolobular_carcinoma NS NS n COSV104577192 COSM9359618 174357073 c.1155C>A p.C385* Substitution - Nonsense 38 7:55165330-55165330 + - NEUTRAL .48246 Confirmed somatic variant 30205045 surgery-fixed primary 68 ENSP00000492462.1:p.Cys385Ter ENST00000638463.1:c.1155C>A 7:g.55165330C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-46-3765-01 1781761 1685760 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51850921 COSM5982763 174334905 c.1261G>T p.G421* Substitution - Nonsense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 418 fresh/frozen - NOS primary 59 ENSP00000492462.1:p.Gly421Ter ENST00000638463.1:c.1261G>T 7:g.55165436G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 SJG-018 2561465 2422889 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS y COSV51850921 COSM5982763 174334905 c.1261G>T p.G421* Substitution - Nonsense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 27693639 short-term culture primary 79 ENSP00000492462.1:p.Gly421Ter ENST00000638463.1:c.1261G>T 7:g.55165436G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 10-428 1960462 1847022 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51833036 COSM1645315 174334809 c.315T>A p.C105* Substitution - Nonsense het 38 7:55155873-55155873 + - NEUTRAL .23167 Confirmed somatic variant 23700467 fresh/frozen - NOS primary ENSP00000492462.1:p.Cys105Ter ENST00000638463.1:c.315T>A 7:g.55155873T>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-D3-A8GI-06 2263025 2130009 skin NS NS NS malignant_melanoma NS NS NS y COSV51850302 COSM6005744 174335280 c.1123C>T p.Q375* Substitution - Nonsense 38 7:55165298-55165298 + - NEUTRAL .15904 Confirmed somatic variant 540 NS NS 68 ENSP00000492462.1:p.Gln375Ter ENST00000638463.1:c.1123C>T 7:g.55165298C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 BL-17-R06450 2905627 2759883 NS NS NS NS malignant_melanoma NS NS NS n COSV105864534 COSM9990949 124968908 c.154C>T p.Q52* Substitution - Nonsense 38 7:55142351-55142351 + - PATHOGENIC .86004 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000413843.2:p.Gln52Ter ENST00000420316.6:c.154C>T 7:g.55142351C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 DND41 1760521 1665124 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51782203 COSM327143 124949648 c.211C>T p.Q71* Substitution - Nonsense 38 7:55142408-55142408 + - PATHOGENIC .91839 Variant of unknown origin 22675565 cell-line NS ENSP00000413843.2:p.Gln71Ter ENST00000420316.6:c.211C>T 7:g.55142408C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 143 2748115 2606818 stomach NS NS NS carcinoma NS NS NS y COSV99286726 COSM8594240 124967844 c.1198G>T p.E400* Substitution - Nonsense 38 7:55156823-55156823 + - PATHOGENIC .99626 Confirmed somatic variant 683 NS primary ENSP00000413843.2:p.Glu400Ter ENST00000420316.6:c.1198G>T 7:g.55156823G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GCTK_315_T 2747417 2606120 stomach NS NS NS carcinoma NS NS NS y COSV51812362 COSM4773811 124951011 c.599G>A p.W200* Substitution - Nonsense 38 7:55151333-55151333 + - PATHOGENIC .99472 Confirmed somatic variant 683 NS primary ENSP00000413843.2:p.Trp200Ter ENST00000420316.6:c.599G>A 7:g.55151333G>A FCGR3A_ENST00000367967 ENST00000367967.7 765 3619 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV63459571 COSM530144 109795362 c.700C>T p.R234* Substitution - Nonsense 38 1:161543077-161543077 - - NEUTRAL .26854 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000356944.3:p.Arg234Ter ENST00000367967.7:c.700C>T 1:g.161543077G>A CR1_ENST00000367051 ENST00000367051.6 6120 2334 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65455967 COSM301989 110414717 c.5230C>T p.R1744* Substitution - Nonsense 38 1:207614408-207614408 + - NEUTRAL .07353 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000356018.1:p.Arg1744Ter ENST00000367051.6:c.5230C>T 1:g.207614408C>T CR1_ENST00000367051 ENST00000367051.6 6120 2334 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65455974 COSM341835 110414985 c.5308G>T p.E1770* Substitution - Nonsense 38 1:207614486-207614486 + - PATHOGENIC .82817 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000356018.1:p.Glu1770Ter ENST00000367051.6:c.5308G>T 1:g.207614486G>T DDI1 ENST00000302259.4 1191 18961 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV56374601 COSM922420 102251619 c.1177C>T p.R393* Substitution - Nonsense 38 11:104037999-104037999 + - NEUTRAL .02769 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000302805.3:p.Arg393Ter ENST00000302259.4:c.1177C>T 11:g.104037999C>T FCGR3A_ENST00000443193 ENST00000443193.5 765 3619 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV63459571 COSM530144 126635607 c.700C>T p.R234* Substitution - Nonsense 38 1:161543077-161543077 - - NEUTRAL .26854 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000392047.2:p.Arg234Ter ENST00000443193.5:c.700C>T 1:g.161543077G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 YUROG 2439363 2302204 skin NS NS NS malignant_melanoma NS NS NS y COSV51803180 COSM5407716 124970182 c.622C>T p.Q208* Substitution - Nonsense het 38 7:55151356-55151356 + - PATHOGENIC .99214 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 58 ENSP00000413843.2:p.Gln208Ter ENST00000420316.6:c.622C>T 7:g.55151356C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0211-02 2120254 1994490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51804002 COSM3412186 124963842 c.826C>T p.Q276* Substitution - Nonsense 38 7:55154089-55154089 + - PATHOGENIC .94288 Confirmed somatic variant 329 NS NS 48 ENSP00000413843.2:p.Gln276Ter ENST00000420316.6:c.826C>T 7:g.55154089C>T FCGR3A_ENST00000436743 ENST00000436743.5 765 3619 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV63459571 COSM530144 130096612 c.700C>T p.R234* Substitution - Nonsense 38 1:161543077-161543077 - - NEUTRAL .26854 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000416607.1:p.Arg234Ter ENST00000436743.5:c.700C>T 1:g.161543077G>A TMEM255B_ENST00000488362 ENST00000488362.5 501 28297 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV100943364 COSM7454211 140574197 c.211G>T p.G71* Substitution - Nonsense 38 13:113769119-113769119 + - PATHOGENIC .97575 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000479391.1:p.Gly71Ter ENST00000488362.5:c.211G>T 13:g.113769119G>T NAPSA ENST00000253719.6 1263 13395 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105874837 COSM10012847 97766245 c.97C>T p.R33* Substitution - Nonsense 38 19:50362300-50362300 - - NEUTRAL .04055 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000253719.1:p.Arg33Ter ENST00000253719.6:c.97C>T 19:g.50362300G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-AG-3881-01 1651557 1566344 large_intestine rectum NS NS NS NS NS NS y COSV99292247 COSM7522737 124962656 c.1015G>T p.G339* Substitution - Nonsense 38 7:55156541-55156541 + - PATHOGENIC .99616 Confirmed somatic variant 375 NS primary 83 ENSP00000413843.2:p.Gly339Ter ENST00000420316.6:c.1015G>T 7:g.55156541G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GC_315T-GC_315N 2324594 2189703 stomach NS NS NS carcinoma diffuse_adenocarcinoma NS NS y COSV51812362 COSM4773811 124951011 c.599G>A p.W200* Substitution - Nonsense 38 7:55151333-55151333 + - PATHOGENIC .99472 Confirmed somatic variant 24816255 surgery fresh/frozen NS ENSP00000413843.2:p.Trp200Ter ENST00000420316.6:c.599G>A 7:g.55151333G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 10-428 1960462 1847022 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51833036 COSM1645315 124952659 c.933T>A p.C311* Substitution - Nonsense het 38 7:55155873-55155873 + - NEUTRAL .23167 Confirmed somatic variant 23700467 fresh/frozen - NOS primary ENSP00000413843.2:p.Cys311Ter ENST00000420316.6:c.933T>A 7:g.55155873T>A ARSG_ENST00000621439 ENST00000621439.4 1578 24102 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV71593687 COSM193997 168958723 c.391G>A p.V131I Substitution - Missense 38 17:68343776-68343776 + - NEUTRAL .09327 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000480910.1:p.Val131Ile ENST00000621439.4:c.391G>A 17:g.68343776G>A CDC27_ENST00000066544 ENST00000066544.7 2475 1728 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV50397621 COSM472929 97378711 c.601G>A p.V201I Substitution - Missense 38 17:47157259-47157259 - - PATHOGENIC .97866 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000066544.3:p.Val201Ile ENST00000066544.7:c.601G>A 17:g.47157259C>T DCAF4_ENST00000353777 ENST00000353777.7 978 20229 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105912372 COSM10012834 110726309 c.320G>A p.R107Q Substitution - Missense 38 14:72940346-72940346 + - NEUTRAL .14934 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000345176.3:p.Arg107Gln ENST00000353777.7:c.320G>A 14:g.72940346G>A WSCD1_ENST00000573634 ENST00000573634.5 1380 29060 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV58497674 COSM4749261 161205759 c.347G>A p.R116H Substitution - Missense 38 17:6090473-6090473 + - PATHOGENIC .71202 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000460396.1:p.Arg116His ENST00000573634.5:c.347G>A 17:g.6090473G>A RYR2_ENST00000360064 ENST00000360064.7 14850 10484 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105921013 COSM10012917 111842461 c.12390G>C p.E4130D Substitution - Missense 38 1:237784150-237784150 + - PATHOGENIC .92502 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000353174.7:p.Glu4130Asp ENST00000360064.7:c.12390G>C 1:g.237784150G>C KCND3_ENST00000302127 ENST00000302127.4 1911 6239 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105875997 COSM10012826 102116078 c.740C>T p.A247V Substitution - Missense 38 1:111981987-111981987 - - PATHOGENIC .96322 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000306923.3:p.Ala247Val ENST00000302127.4:c.740C>T 1:g.111981987G>A CDC27_ENST00000527547 ENST00000527547.5 2472 1728 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV50397621 COSM472929 152385503 c.601G>A p.V201I Substitution - Missense 38 17:47157259-47157259 - - PATHOGENIC .97866 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000437339.1:p.Val201Ile ENST00000527547.5:c.601G>A 17:g.47157259C>T NOX5_ENST00000260364 ENST00000260364.9 2244 14874 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105871370 COSM10012832 97256720 c.1133A>T p.E378V Substitution - Missense 38 15:69035935-69035935 + - PATHOGENIC .81287 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000454143.1:p.Glu378Val ENST00000260364.9:c.1133A>T 15:g.69035935A>T L3MBTL1_ENST00000427442 ENST00000427442.7 2607 15905 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105927443 COSM10012772 126578447 c.1670G>A p.R557K Substitution - Missense 38 20:43534336-43534336 + - PATHOGENIC .99127 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000402107.3:p.Arg557Lys ENST00000427442.7:c.1670G>A 20:g.43534336G>A LRRN4 ENST00000378858.4 2223 16208 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105933015 COSM10012846 114918157 c.1723G>A p.G575R Substitution - Missense 38 20:6041522-6041522 - - NEUTRAL .09146 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000368135.4:p.Gly575Arg ENST00000378858.4:c.1723G>A 20:g.6041522C>T NEU3 ENST00000294064.8 1386 7760 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105876930 COSM10012896 98737135 c.520G>T p.V174L Substitution - Missense 38 11:75005626-75005626 + - NEUTRAL .3053 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000294064.4:p.Val174Leu ENST00000294064.8:c.520G>T 11:g.75005626G>T OR10K1_ENST00000641971 ENST00000641971.1 942 14693 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV56872727 COSM5698964 175877656 c.346G>T p.A116S Substitution - Missense 38 1:158465907-158465907 + - .50134 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000492890.1:p.Ala116Ser ENST00000641971.1:c.346G>T 1:g.158465907G>T SIGLECL1 ENST00000316401.11 594 26856 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105882075 COSM10012895 104542947 c.437C>T p.A146V Substitution - Missense 38 19:51267399-51267399 + - NEUTRAL .10189 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000321249.6:p.Ala146Val ENST00000316401.11:c.437C>T 19:g.51267399C>T GOLGA6B ENST00000421285.3 2082 32205 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV101406901 COSM8983052 122926411 c.1063C>T p.R355W Substitution - Missense 38 15:72662467-72662467 + - NEUTRAL .04475 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000408132.3:p.Arg355Trp ENST00000421285.3:c.1063C>T 15:g.72662467C>T KCNK2_ENST00000391894 ENST00000391894.6 1236 6277 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105930970 COSM10012965 117380676 c.231G>T p.R77S Substitution - Missense 38 1:215086597-215086597 + - PATHOGENIC .96743 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000375764.2:p.Arg77Ser ENST00000391894.6:c.231G>T 1:g.215086597G>T DCAF4_ENST00000555042 ENST00000555042.5 1470 20229 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105912372 COSM10012834 158980208 c.320G>A p.R107Q Substitution - Missense 38 14:72940346-72940346 + - NEUTRAL .14934 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000452131.1:p.Arg107Gln ENST00000555042.5:c.320G>A 14:g.72940346G>A HMOX1 ENST00000216117.8 867 5013 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105862311 COSM10012809 97951378 c.554G>A p.R185H Substitution - Missense 38 22:35387094-35387094 + - PATHOGENIC .99165 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000216117.8:p.Arg185His ENST00000216117.8:c.554G>A 22:g.35387094G>A SCN2A_ENST00000375427 ENST00000375427.4 6018 10588 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105873046 COSM10012780 112987402 c.5288C>A p.S1763Y Substitution - Missense 38 2:165389094-165389094 + - PATHOGENIC .98186 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000364576.2:p.Ser1763Tyr ENST00000375427.4:c.5288C>A 2:g.165389094C>A CEACAM20_ENST00000620096 ENST00000620096.4 1476 24879 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105885448 COSM10012840 168665895 c.211T>C p.S71P Substitution - Missense 38 19:44524247-44524247 - - NEUTRAL .07541 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000481812.1:p.Ser71Pro ENST00000620096.4:c.211T>C 19:g.44524247A>G ASCC3 ENST00000369162.6 6609 18697 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105922204 COSM10012796 109575987 c.6451A>T p.I2151L Substitution - Missense 38 6:100509942-100509942 - - NEUTRAL .1373 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000358159.2:p.Ile2151Leu ENST00000369162.6:c.6451A>T 6:g.100509942T>A SLC4A4_ENST00000351898 ENST00000351898.10 2988 11030 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV52623703 COSM420534 109364122 c.2308G>A p.V770I Substitution - Missense 38 4:71534254-71534254 + - PATHOGENIC .91286 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000307349.7:p.Val770Ile ENST00000351898.10:c.2308G>A 4:g.71534254G>A IFT22_ENST00000498704 ENST00000498704.6 327 21895 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105876048 COSM10012944 141713554 c.16G>A p.G6R Substitution - Missense 38 7:101316502-101316502 - - PATHOGENIC .98716 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000429648.1:p.Gly6Arg ENST00000498704.6:c.16G>A 7:g.101316502C>T RHOB ENST00000272233.5 591 668 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105844268 COSM10012793 97171861 c.181G>A p.A61T Substitution - Missense 38 2:20447646-20447646 + - PATHOGENIC .8921 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000272233.4:p.Ala61Thr ENST00000272233.5:c.181G>A 2:g.20447646G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2862107 2862107 2717309 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV105111081 COSM9572577 104567168 c.1453G>A p.G485S Substitution - Missense 38 7:55160293-55160293 + - NEUTRAL .00282 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000345973.2:p.Gly485Ser ENST00000344576.6:c.1453G>A 7:g.55160293G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2840810 2840810 2696370 prostate NS NS NS carcinoma NS NS NS n COSV104577207 COSM9493802 104596644 c.686G>A p.S229N Substitution - Missense 38 7:55152603-55152603 + - PATHOGENIC .9474 Variant of unknown origin 31874108 surgery-fixed metastasis ENSP00000345973.2:p.Ser229Asn ENST00000344576.6:c.686G>A 7:g.55152603G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 5-GE067-T1 2869773 2724770 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51802062 COSM6008937 104567373 c.659C>T p.S220F Substitution - Missense 38 7:55152576-55152576 + - PATHOGENIC .98424 Variant of unknown origin 26950094 surgery - NOS NS ENSP00000345973.2:p.Ser220Phe ENST00000344576.6:c.659C>T 7:g.55152576C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194724 1194724 1106619 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849762 COSM29340 104595681 c.818C>A p.T273N Substitution - Missense 38 7:55154081-55154081 + - PATHOGENIC .90357 Variant of unknown origin 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Thr273Asn ENST00000344576.6:c.818C>A 7:g.55154081C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0000030-T01-IM3 2714482 2573303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51789972 COSM6985979 104571133 c.903_906delinsACAC p.T302H Substitution - Missense het 38 7:55155843-55155846 + - Variant of unknown origin 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Thr302His ENST00000344576.6:c.903_906delinsACAC 7:g.55155843_55155846delinsACAC EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-24-1850-01 1731201 1637167 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51792742 COSM1330578 104595020 c.783G>T p.K261N Substitution - Missense het 38 7:55154046-55154046 + - PATHOGENIC .96256 Variant of unknown origin 331 NS primary 72 ENSP00000345973.2:p.Lys261Asn ENST00000344576.6:c.783G>T 7:g.55154046G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 LC20 2439238 2302079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51781350 COSM5369838 104574352 c.407C>G p.P136R Substitution - Missense 38 7:55143471-55143471 + - PATHOGENIC .90708 Variant of unknown origin 26164066 surgery-fixed metastasis ENSP00000345973.2:p.Pro136Arg ENST00000344576.6:c.407C>G 7:g.55143471C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 UCHRP3 2682242 2541515 large_intestine NS NS NS other ulcerative_colitis dysplasia NS n COSV51844399 COSM6854571 104573155 c.1809C>A p.N603K Substitution - Missense 38 7:55165366-55165366 + - PATHOGENIC .87723 Variant of unknown origin 28524162 surgery fresh/frozen NS 54 ENSP00000345973.2:p.Asn603Lys ENST00000344576.6:c.1809C>A 7:g.55165366C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 UCHRP3 2682242 2541515 large_intestine NS NS NS other ulcerative_colitis dysplasia NS n COSV51844380 COSM6854567 104573149 c.856A>G p.S286G Substitution - Missense 38 7:55154119-55154119 + - PATHOGENIC .99273 Variant of unknown origin 28524162 surgery fresh/frozen NS 54 ENSP00000345973.2:p.Ser286Gly ENST00000344576.6:c.856A>G 7:g.55154119A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2862120 2862120 2717322 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV105110976 COSM9572578 104567173 c.1631G>A p.G544D Substitution - Missense 38 7:55161631-55161631 + - PATHOGENIC .99386 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000345973.2:p.Gly544Asp ENST00000344576.6:c.1631G>A 7:g.55161631G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SUPT1 1760532 1665135 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51819830 COSM327147 104568788 c.752G>A p.C251Y Substitution - Missense 38 7:55154015-55154015 + - PATHOGENIC .98182 Variant of unknown origin 22675565 cell-line NS ENSP00000345973.2:p.Cys251Tyr ENST00000344576.6:c.752G>A 7:g.55154015G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-55-7570-01 1914018 1802300 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51813309 COSM6178064 104592774 c.898G>A p.V300M Substitution - Missense 38 7:55155838-55155838 + - PATHOGENIC .97875 Variant of unknown origin 417 fresh/frozen - NOS primary 60 ENSP00000345973.2:p.Val300Met ENST00000344576.6:c.898G>A 7:g.55155838G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194739 1194739 1106634 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51818096 COSM29341 104581934 c.1860C>G p.C620W Substitution - Missense 38 7:55165417-55165417 + - PATHOGENIC .989 Variant of unknown origin 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Cys620Trp ENST00000344576.6:c.1860C>G 7:g.55165417C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732915 2732915 2591668 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827181 COSM7002280 104586721 c.574C>G p.P192A Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .86378 Variant of unknown origin 28855349 surgery - NOS recurrent 58 ENSP00000345973.2:p.Pro192Ala ENST00000344576.6:c.574C>G 7:g.55151308C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-08-0349-01 1910225 1798516 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51830791 COSM43068 104595352 c.977G>A p.C326Y Substitution - Missense het 38 7:55155917-55155917 + - PATHOGENIC .99356 Variant of unknown origin 329 fresh/frozen - NOS primary 46 ENSP00000345973.2:p.Cys326Tyr ENST00000344576.6:c.977G>A 7:g.55155917G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 LUAD_E01166 1765174 1669494 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51795467 COSM390866 104571479 c.709_710delinsTA p.A237Y Substitution - Missense 38 7:55152626-55152627 + - Variant of unknown origin 22980975 surgery - NOS primary ENSP00000345973.2:p.Ala237Tyr ENST00000344576.6:c.709_710delinsTA 7:g.55152626_55152627delinsTA EGFR_ENST00000344576 ENST00000344576.6 2118 3236 5-GE049-T1 2869762 2724759 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110412 COSM9799019 104596627 c.583C>T p.P195S Substitution - Missense 38 7:55151317-55151317 + - NEUTRAL .41768 Variant of unknown origin 26950094 surgery - NOS NS 80 ENSP00000345973.2:p.Pro195Ser ENST00000344576.6:c.583C>T 7:g.55151317C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2841222 2841222 2696782 prostate NS NS NS carcinoma NS NS NS n COSV104577073 COSM9497234 104593931 c.434A>G p.H145R Substitution - Missense 38 7:55146615-55146615 + - NEUTRAL .16662 Variant of unknown origin 31874108 surgery-fixed primary ENSP00000345973.2:p.His145Arg ENST00000344576.6:c.434A>G 7:g.55146615A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2857410 2857410 2712710 skin NS NS NS malignant_melanoma NS NS NS n COSV51767869 COSM3266583 104563865 c.1351C>T p.R451C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 31980996 surgery-fixed NS ENSP00000345973.2:p.Arg451Cys ENST00000344576.6:c.1351C>T 7:g.55160191C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 LUAD-NYU408 1765248 1669568 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51855104 COSM374570 104567695 c.1721G>T p.R574L Substitution - Missense 38 7:55163822-55163822 + - PATHOGENIC .93703 Variant of unknown origin 22980975 surgery - NOS primary 71 ENSP00000345973.2:p.Arg574Leu ENST00000344576.6:c.1721G>T 7:g.55163822G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 BL-14-K28959 2905665 2759921 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864429 COSM9990414 104568400 c.2101G>T p.A701S Substitution - Missense 38 7:55170527-55170527 + - NEUTRAL .03256 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000345973.2:p.Ala701Ser ENST00000344576.6:c.2101G>T 7:g.55170527G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 AC-V16-Tumor-SM-9J46H 2584492 2445656 large_intestine anus NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51811313 COSM6008958 104563459 c.745C>G p.L249V Substitution - Missense 38 7:55152662-55152662 + - PATHOGENIC .95619 Variant of unknown origin 27852700 surgery-fixed recurrent ENSP00000345973.2:p.Leu249Val ENST00000344576.6:c.745C>G 7:g.55152662C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 LIM1215_R1_Cetux 2841367 2696923 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576981 COSM9396333 104590811 c.1473A>G p.I491M Substitution - Missense 38 7:55160313-55160313 + - NEUTRAL .12443 Variant of unknown origin 25623215 cell-line NS ENSP00000345973.2:p.Ile491Met ENST00000344576.6:c.1473A>G 7:g.55160313A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MBC032T 2807217 2663921 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99296355 COSM9120806 104592595 c.1655A>C p.N552T Substitution - Missense 38 7:55163756-55163756 + - PATHOGENIC .99524 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000345973.2:p.Asn552Thr ENST00000344576.6:c.1655A>C 7:g.55163756A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PD42092a 2894833 2749321 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV105110933 COSM9881280 104585441 c.1574C>T p.S525F Substitution - Missense 38 7:55161574-55161574 + - PATHOGENIC .96213 Variant of unknown origin 33024263 surgery-fixed metastasis 75 ENSP00000345973.2:p.Ser525Phe ENST00000344576.6:c.1574C>T 7:g.55161574C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2626134 2626134 2486546 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51791433 COSM6191492 104592155 c.887_888delinsTT p.P296L Substitution - Missense 38 7:55154150-55154151 + - Variant of unknown origin 26645239 surgery-fixed NS ENSP00000345973.2:p.Pro296Leu ENST00000344576.6:c.887_888delinsTT 7:g.55154150_55154151delinsTT EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SW1116 2302012 2167295 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51793482 COSM3266615 104567904 c.1960G>A p.V654M Substitution - Missense het 38 7:55170386-55170386 + - NEUTRAL .00515 Variant of unknown origin 24755471 cell-line NS ENSP00000345973.2:p.Val654Met ENST00000344576.6:c.1960G>A 7:g.55170386G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 VOA1947 2897843 2752142 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105864361 COSM9970409 104588972 c.970C>T p.R324C Substitution - Missense 38 7:55155910-55155910 + - PATHOGENIC .91299 Variant of unknown origin 31477716 surgery-fixed metastasis 69 ENSP00000345973.2:p.Arg324Cys ENST00000344576.6:c.970C>T 7:g.55155910C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-08-0246-01 1910219 1798510 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51792876 COSM43066 104564873 c.767A>C p.D256A Substitution - Missense hom 38 7:55154030-55154030 + - PATHOGENIC .98125 Variant of unknown origin 329 fresh/frozen - NOS primary 57 ENSP00000345973.2:p.Asp256Ala ENST00000344576.6:c.767A>C 7:g.55154030A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-02-0116-01 1910165 1798456 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51795519 COSM35822 104595571 c.1789G>C p.A597P Substitution - Missense hom 38 7:55165346-55165346 + - NEUTRAL .2004 Variant of unknown origin 329 fresh/frozen - NOS primary 54 ENSP00000345973.2:p.Ala597Pro ENST00000344576.6:c.1789G>C 7:g.55165346G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-78-7147-01 1914054 1802336 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51797369 COSM6178060 104588252 c.1159C>A p.L387M Substitution - Missense 38 7:55156784-55156784 + - PATHOGENIC .85999 Variant of unknown origin 417 fresh/frozen - NOS primary 67 ENSP00000345973.2:p.Leu387Met ENST00000344576.6:c.1159C>A 7:g.55156784C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NAN8 2809783 2666453 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV99289304 COSM9153919 104576273 c.670C>T p.R224C Substitution - Missense het 38 7:55152587-55152587 + - PATHOGENIC .90413 Variant of unknown origin 30545397 cell-line primary ENSP00000345973.2:p.Arg224Cys ENST00000344576.6:c.670C>T 7:g.55152587C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MBC531 2807310 2664014 breast NS NS NS carcinoma NS NS NS n COSV99286738 COSM9120811 104595687 c.1219A>G p.I407V Substitution - Missense 38 7:55157674-55157674 + - PATHOGENIC .99284 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000345973.2:p.Ile407Val ENST00000344576.6:c.1219A>G 7:g.55157674A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 AMO1 2809758 2666428 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasmacytoma NS NS y COSV51777457 COSM1236015 104574570 c.627A>C p.K209N Substitution - Missense het 38 7:55151361-55151361 + - NEUTRAL .14933 Variant of unknown origin 30545397 cell-line NS ENSP00000345973.2:p.Lys209Asn ENST00000344576.6:c.627A>C 7:g.55151361A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 OV207 1716842 1624327 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51806026 COSM252488 104581955 c.493C>T p.R165W Substitution - Missense 38 7:55146674-55146674 + - NEUTRAL .14815 Variant of unknown origin 22102435 surgery fresh/frozen NS ENSP00000345973.2:p.Arg165Trp ENST00000344576.6:c.493C>T 7:g.55146674C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 DM16 2466857 2329688 skin head_neck NS NS malignant_melanoma desmoplastic NS NS n COSV51842833 COSM5608338 104586451 c.794C>T p.P265L Substitution - Missense 38 7:55154057-55154057 + - PATHOGENIC .98876 Variant of unknown origin 26343386 surgery-fixed NS 80 ENSP00000345973.2:p.Pro265Leu ENST00000344576.6:c.794C>T 7:g.55154057C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 VOA1720 2897846 2752145 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105864482 COSM9969894 104590290 c.494G>C p.R165P Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .25613 Variant of unknown origin 31477716 surgery-fixed NS 73 ENSP00000345973.2:p.Arg165Pro ENST00000344576.6:c.494G>C 7:g.55146675G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2585427 2585427 2446591 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51767869 COSM3266583 104563865 c.1351C>T p.R451C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 25623215 surgery - NOS recurrent ENSP00000345973.2:p.Arg451Cys ENST00000344576.6:c.1351C>T 7:g.55160191C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 WSU-HN30 2296299 2161902 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51845363 COSM4600429 104565083 c.316A>T p.I106F Substitution - Missense 38 7:55143380-55143380 + - PATHOGENIC .97255 Variant of unknown origin 25275298 cell-line NS ENSP00000345973.2:p.Ile106Phe ENST00000344576.6:c.316A>T 7:g.55143380A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732914 2732914 2591667 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827181 COSM7002280 104586721 c.574C>G p.P192A Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .86378 Variant of unknown origin 28855349 surgery - NOS primary 58 ENSP00000345973.2:p.Pro192Ala ENST00000344576.6:c.574C>G 7:g.55151308C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 LPS39 2800474 2657290 soft_tissue fat retroperitoneum NS liposarcoma well_differentiated NS NS n COSV99285595 COSM9110950 104596120 c.1903G>T p.A635S Substitution - Missense 38 7:55170329-55170329 + - NEUTRAL .03715 Variant of unknown origin 26643872 surgery - NOS primary 57 ENSP00000345973.2:p.Ala635Ser ENST00000344576.6:c.1903G>T 7:g.55170329G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 ESO-721 1890961 1780330 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV51788608 COSM1251016 104570545 c.1340C>A p.S447Y Substitution - Missense 38 7:55160180-55160180 + - .5293 Variant of unknown origin 23525077 surgery fresh/frozen primary 68 ENSP00000345973.2:p.Ser447Tyr ENST00000344576.6:c.1340C>A 7:g.55160180C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00226T00226 2857365 2712665 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 104577737 c.1162G>A p.D388N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000345973.2:p.Asp388Asn ENST00000344576.6:c.1162G>A 7:g.55156787G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 DM10 2466851 2329682 skin face NS NS malignant_melanoma desmoplastic NS NS n COSV51850876 COSM5608334 104570071 c.1357C>T p.L453F Substitution - Missense 38 7:55160197-55160197 + - PATHOGENIC .96542 Variant of unknown origin 26343386 surgery-fixed NS 70 ENSP00000345973.2:p.Leu453Phe ENST00000344576.6:c.1357C>T 7:g.55160197C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 H1793 2776325 2634461 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51866889 COSM3266567 104568773 c.932G>T p.C311F Substitution - Missense 38 7:55155872-55155872 + - PATHOGENIC .99418 Variant of unknown origin 29681454 NS NS 52 ENSP00000345973.2:p.Cys311Phe ENST00000344576.6:c.932G>T 7:g.55155872G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2 2557184 2418609 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51828150 COSM5976431 104564519 c.1555G>A p.E519K Substitution - Missense 38 7:55161555-55161555 + - PATHOGENIC .8557 Variant of unknown origin 26934577 surgery fresh/frozen NS ENSP00000345973.2:p.Glu519Lys ENST00000344576.6:c.1555G>A 7:g.55161555G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105111181 COSM9542450 104577716 c.61G>A p.A21T Substitution - Missense 38 7:55019338-55019338 + - NEUTRAL .06121 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000345973.2:p.Ala21Thr ENST00000344576.6:c.61G>A 7:g.55019338G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 BL-18-K10011 2905035 2759291 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864163 COSM10000367 104582009 c.407C>A p.P136H Substitution - Missense 38 7:55143471-55143471 + - PATHOGENIC .91703 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000345973.2:p.Pro136His ENST00000344576.6:c.407C>A 7:g.55143471C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-95-7947-01 1914103 1802385 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51819886 COSM6178068 104566912 c.271A>G p.I91V Substitution - Missense 38 7:55143335-55143335 + - PATHOGENIC .98845 Variant of unknown origin 417 fresh/frozen - NOS primary 67 ENSP00000345973.2:p.Ile91Val ENST00000344576.6:c.271A>G 7:g.55143335A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 DM51 2466875 2329706 skin neck NS NS malignant_melanoma desmoplastic NS NS n COSV51774157 COSM5608355 104586099 c.1806A>T p.E602D Substitution - Missense 38 7:55165363-55165363 + - PATHOGENIC .71202 Variant of unknown origin 26343386 surgery-fixed NS 88 ENSP00000345973.2:p.Glu602Asp ENST00000344576.6:c.1806A>T 7:g.55165363A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 BL-18-G33649 2905020 2759276 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS n COSV105864538 COSM10000671 104591854 c.2068C>T p.H690Y Substitution - Missense 38 7:55170494-55170494 + - NEUTRAL .00818 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000345973.2:p.His690Tyr ENST00000344576.6:c.2068C>T 7:g.55170494C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 104577737 c.1162G>A p.D388N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000345973.2:p.Asp388Asn ENST00000344576.6:c.1162G>A 7:g.55156787G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GBC_6 2907852 2762035 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV105864473 COSM10029109 104590396 c.1360A>G p.K454E Substitution - Missense 38 7:55160200-55160200 + - PATHOGENIC .95086 Variant of unknown origin 33563892 surgery-fixed NS 85 ENSP00000345973.2:p.Lys454Glu ENST00000344576.6:c.1360A>G 7:g.55160200A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51841184 COSM1090877 104564690 c.1621C>A p.L541I Substitution - Missense het 38 7:55161621-55161621 + - NEUTRAL .01946 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000345973.2:p.Leu541Ile ENST00000344576.6:c.1621C>A 7:g.55161621C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 KYSE70 2395008 2257839 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51816584 COSM3266617 104561925 c.2015C>G p.P672R Substitution - Missense 38 7:55170441-55170441 + - NEUTRAL .01508 Variant of unknown origin 24686850 cell-line NS ENSP00000345973.2:p.Pro672Arg ENST00000344576.6:c.2015C>G 7:g.55170441C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 UVDUD0 2762706 2620965 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51767906 COSM7340119 104591353 c.433C>A p.H145N Substitution - Missense 38 7:55146614-55146614 + - NEUTRAL .01483 Variant of unknown origin 29615459 NS primary 63 ENSP00000345973.2:p.His145Asn ENST00000344576.6:c.433C>A 7:g.55146614C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51841162 COSM1090865 104564678 c.594C>A p.S198R Substitution - Missense het 38 7:55151328-55151328 + - PATHOGENIC .8706 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000345973.2:p.Ser198Arg ENST00000344576.6:c.594C>A 7:g.55151328C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 OX-CO-2_R2_Cetux 2841377 2696927 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576981 COSM9396333 104590811 c.1473A>G p.I491M Substitution - Missense 38 7:55160313-55160313 + - NEUTRAL .12443 Variant of unknown origin 25623215 cell-line NS ENSP00000345973.2:p.Ile491Met ENST00000344576.6:c.1473A>G 7:g.55160313A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 ESO-732 1890962 1780331 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV51780511 COSM1251018 104591220 c.1960G>T p.V654L Substitution - Missense 38 7:55170386-55170386 + - NEUTRAL .00278 Variant of unknown origin 23525077 surgery fresh/frozen primary 62 ENSP00000345973.2:p.Val654Leu ENST00000344576.6:c.1960G>T 7:g.55170386G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 UM-SCC-17B 2296307 2161910 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825836 COSM4599146 104575981 c.345T>A p.N115K Substitution - Missense 38 7:55143409-55143409 + - NEUTRAL .2671 Variant of unknown origin 25275298 cell-line NS 47 ENSP00000345973.2:p.Asn115Lys ENST00000344576.6:c.345T>A 7:g.55143409T>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-273-tumor 2819121 2675420 meninges NS NS NS meningioma anaplastic NS NS n COSV104369217 COSM9267459 104580798 c.1414G>A p.A472T Substitution - Missense 38 7:55160254-55160254 + - PATHOGENIC .94147 Variant of unknown origin 28713588 surgery - NOS NS ENSP00000345973.2:p.Ala472Thr ENST00000344576.6:c.1414G>A 7:g.55160254G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 KARPAS45 1760525 1665128 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51767338 COSM327145 104568160 c.227T>C p.L76P Substitution - Missense 38 7:55142424-55142424 + - PATHOGENIC .97399 Variant of unknown origin 22675565 cell-line NS ENSP00000345973.2:p.Leu76Pro ENST00000344576.6:c.227T>C 7:g.55142424T>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 RDES 2294586 2160613 bone NS NS NS Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour NS NS NS y COSV51793186 COSM4587483 104586517 c.1798A>G p.M600V Substitution - Missense 38 7:55165355-55165355 + - PATHOGENIC .89999 Variant of unknown origin 25186949 cell-line NS ENSP00000345973.2:p.Met600Val ENST00000344576.6:c.1798A>G 7:g.55165355A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732917 2732917 2591670 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827197 COSM7002281 104585368 c.1784G>A p.C595Y Substitution - Missense 38 7:55165341-55165341 + - PATHOGENIC .99683 Variant of unknown origin 28855349 surgery - NOS primary 39 ENSP00000345973.2:p.Cys595Tyr ENST00000344576.6:c.1784G>A 7:g.55165341G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TMIT_I_12 2765652 2623896 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV99034441 COSM7346604 104566197 c.1123G>A p.A375T Substitution - Missense 38 7:55156649-55156649 + - PATHOGENIC .97686 Variant of unknown origin 30239046 surgery-fixed NS ENSP00000345973.2:p.Ala375Thr ENST00000344576.6:c.1123G>A 7:g.55156649G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 AMO1 1889514 1778954 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV51777457 COSM1236015 104574570 c.627A>C p.K209N Substitution - Missense 38 7:55151361-55151361 + - NEUTRAL .14933 Variant of unknown origin 23396385 cell-line NS ENSP00000345973.2:p.Lys209Asn ENST00000344576.6:c.627A>C 7:g.55151361A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00243T00243 2857340 2712640 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105111181 COSM9542450 104577716 c.61G>A p.A21T Substitution - Missense 38 7:55019338-55019338 + - NEUTRAL .06121 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000345973.2:p.Ala21Thr ENST00000344576.6:c.61G>A 7:g.55019338G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2579503 2579503 2440840 NS NS NS NS malignant_melanoma NS NS NS n COSV51849040 COSM6005740 104580634 c.353C>T p.A118V Substitution - Missense 38 7:55143417-55143417 + - PATHOGENIC .99538 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000345973.2:p.Ala118Val ENST00000344576.6:c.353C>T 7:g.55143417C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 DM17 2466858 2329689 skin arm NS NS malignant_melanoma desmoplastic NS NS n COSV51804378 COSM5608346 104589117 c.1558C>T p.P520S Substitution - Missense 38 7:55161558-55161558 + - PATHOGENIC .7492 Variant of unknown origin 26343386 surgery-fixed NS 74 ENSP00000345973.2:p.Pro520Ser ENST00000344576.6:c.1558C>T 7:g.55161558C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00389T00389 2857373 2712673 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 104577737 c.1162G>A p.D388N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000345973.2:p.Asp388Asn ENST00000344576.6:c.1162G>A 7:g.55156787G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2626094 2626094 2486506 lung NS NS NS carcinoid-endocrine_tumour atypical NS NS n COSV51823853 COSM6191491 104561342 c.311T>A p.L104Q Substitution - Missense hom 38 7:55143375-55143375 + - PATHOGENIC .99116 Variant of unknown origin 26645239 surgery-fixed NS ENSP00000345973.2:p.Leu104Gln ENST00000344576.6:c.311T>A 7:g.55143375T>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 DM26 2466862 2329693 skin scalp NS NS malignant_melanoma desmoplastic NS NS n COSV51820811 COSM5611257 104588770 c.1788_1789delinsAA p.A597T Substitution - Missense 38 7:55165345-55165346 + - Variant of unknown origin 26343386 surgery-fixed NS 79 ENSP00000345973.2:p.Ala597Thr ENST00000344576.6:c.1788_1789delinsAA 7:g.55165345_55165346delinsAA EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-144-tumor 2819049 2675348 meninges NS NS NS meningioma atypical NS NS n COSV104369075 COSM9267309 104575117 c.1816C>G p.L606V Substitution - Missense 38 7:55165373-55165373 + - PATHOGENIC .90295 Variant of unknown origin 28713588 surgery - NOS NS ENSP00000345973.2:p.Leu606Val ENST00000344576.6:c.1816C>G 7:g.55165373C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 K5B66H 2762307 2620566 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51767869 COSM3266583 104563865 c.1351C>T p.R451C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 29615459 NS primary 42 ENSP00000345973.2:p.Arg451Cys ENST00000344576.6:c.1351C>T 7:g.55160191C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 LPS3 2800446 2657262 soft_tissue fat NS NS liposarcoma well_differentiated NS NS n COSV99289299 COSM9110946 104583082 c.1249C>T p.L417F Substitution - Missense 38 7:55157704-55157704 + - PATHOGENIC .98762 Variant of unknown origin 26643872 surgery - NOS primary ENSP00000345973.2:p.Leu417Phe ENST00000344576.6:c.1249C>T 7:g.55157704C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 BL-17-E51214 2905659 2759915 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864645 COSM9997785 104594750 c.1721G>A p.R574Q Substitution - Missense 38 7:55163822-55163822 + - PATHOGENIC .88204 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000345973.2:p.Arg574Gln ENST00000344576.6:c.1721G>A 7:g.55163822G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-176-tumor 2819069 2675368 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732608 2732608 2591361 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779091 COSM2155593 104568632 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Reported in another cancer sample as somatic 26757882 surgery-fixed primary 57 ENSP00000345973.2:p.Thr363Ile ENST00000344576.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CCK-81_R1_Cetux 2841357 2696917 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 104569429 c.1391C>T p.S464L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000345973.2:p.Ser464Leu ENST00000344576.6:c.1391C>T 7:g.55160231C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1047 2491942 2354571 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour borderline NS n COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 26437033 surgery fresh/frozen NS 63 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00196T00196 2857366 2712666 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2579678 2579678 2441015 NS NS NS NS malignant_melanoma NS NS NS n COSV51769129 COSM6005742 104572797 c.1801_1802delinsAA p.G601K Substitution - Missense 38 7:55165358-55165359 + - Variant of unknown origin 25148578 surgery-fixed NS ENSP00000345973.2:p.Gly601Lys ENST00000344576.6:c.1801_1802delinsAA 7:g.55165358_55165359delinsAA EGFR_ENST00000344576 ENST00000344576.6 2118 3236 AC-V10-Tumor-SM-9J465 2584480 2445644 large_intestine anus NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51802062 COSM6008937 104567373 c.659C>T p.S220F Substitution - Missense 38 7:55152576-55152576 + - PATHOGENIC .98424 Variant of unknown origin 27852700 surgery-fixed primary ENSP00000345973.2:p.Ser220Phe ENST00000344576.6:c.659C>T 7:g.55152576C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2579438 2579438 2440775 NS NS NS NS malignant_melanoma NS NS NS n COSV51781415 COSM6005739 104583590 c.326G>A p.G109E Substitution - Missense 38 7:55143390-55143390 + - PATHOGENIC .99562 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000345973.2:p.Gly109Glu ENST00000344576.6:c.326G>A 7:g.55143390G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732913 2732913 2591666 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 104563335 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 60 ENSP00000345973.2:p.Ala289Asp ENST00000344576.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-264-tumor 2819115 2675414 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-05-4410-01 1780064 1684063 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51823181 COSM6110421 104582435 c.1131G>T p.R377S Substitution - Missense 38 7:55156657-55156657 + - NEUTRAL .42615 Variant of unknown origin 417 fresh/frozen - NOS primary 62 ENSP00000345973.2:p.Arg377Ser ENST00000344576.6:c.1131G>T 7:g.55156657G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 EGCT1088 2490716 2353365 testis NS NS NS germ_cell_tumour choriocarcinoma NS NS n COSV51835294 COSM5749118 104582743 c.1723G>A p.G575R Substitution - Missense 38 7:55165280-55165280 + - PATHOGENIC .99792 Variant of unknown origin 26956871 surgery fresh/frozen primary ENSP00000345973.2:p.Gly575Arg ENST00000344576.6:c.1723G>A 7:g.55165280G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2509044 2509044 2371379 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 49 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-061-tumor 2819000 2675299 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-AP-A051-01 1783330 1687329 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51848796 COSM1090874 104568819 c.1321G>A p.V441I Substitution - Missense het 38 7:55160161-55160161 + - PATHOGENIC .92435 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000345973.2:p.Val441Ile ENST00000344576.6:c.1321G>A 7:g.55160161G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2808101 2808101 2664786 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 31258848 surgery-fixed NS 60 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00229T00229 2857347 2712647 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MBC067T 2807243 2663947 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99294040 COSM9120802 104570362 c.379G>A p.A127T Substitution - Missense 38 7:55143443-55143443 + - NEUTRAL .01752 Reported in another cancer sample as somatic 31340200 surgery - NOS NS ENSP00000345973.2:p.Ala127Thr ENST00000344576.6:c.379G>A 7:g.55143443G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-02-0023-01 1910131 1798422 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 38 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-081-tumor 2819015 2675314 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-116-tumor 2819038 2675337 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SA-N101 2521507 2383850 central_nervous_system spinal_cord NS NS glioma astrocytoma_Grade_II fibrillary NS n COSV51785554 COSM21688 104562387 c.971G>T p.R324L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Reported in another cancer sample as somatic 26487540 surgery-fixed NS 82 ENSP00000345973.2:p.Arg324Leu ENST00000344576.6:c.971G>T 7:g.55155911G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 BL-18-T40375 2905680 2759936 NS NS NS NS malignant_melanoma NS NS NS n COSV105864576 COSM9994315 104592010 c.1535C>T p.P512L Substitution - Missense 38 7:55161535-55161535 + - NEUTRAL .20165 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000345973.2:p.Pro512Leu ENST00000344576.6:c.1535C>T 7:g.55161535C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 BL-17-W08054 2905635 2759891 urinary_tract NS NS NS carcinoma transitional_cell_carcinoma NS NS n COSV105863907 COSM9995468 104572008 c.1724G>A p.G575E Substitution - Missense 38 7:55165281-55165281 + - PATHOGENIC .99217 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000345973.2:p.Gly575Glu ENST00000344576.6:c.1724G>A 7:g.55165281G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0002PT00040T00040 2857344 2712644 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-38-4629-01 1780093 1684092 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51776247 COSM6110417 104570504 c.1393G>A p.G465R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 68 ENSP00000345973.2:p.Gly465Arg ENST00000344576.6:c.1393G>A 7:g.55160233G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-194-tumor 2819079 2675378 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-209-tumor 2819091 2675390 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-270-tumor 2819119 2675418 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-08-0390-01 1910243 1798534 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 69 ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-08-0390-01 1910243 1798534 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51822289 COSM42977 104574512 c.315G>T p.Q105H Substitution - Missense het 38 7:55143379-55143379 + - PATHOGENIC .90579 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 69 ENSP00000345973.2:p.Gln105His ENST00000344576.6:c.315G>T 7:g.55143379G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2696526 2696526 2555430 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 28201779 surgery fresh/frozen NS 72 ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-089-tumor 2819020 2675319 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S001097 1027690 944666 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 104563335 c.866C>A p.A289D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Ala289Asp ENST00000344576.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 LIM1215_R5_Cetux 2841371 2696923 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51776247 COSM6110417 104570504 c.1393G>A p.G465R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000345973.2:p.Gly465Arg ENST00000344576.6:c.1393G>A 7:g.55160233G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-189-tumor 2819075 2675374 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2509057 2509057 2371392 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51783296 COSM5878511 104586488 c.661G>T p.G221W Substitution - Missense 38 7:55152578-55152578 + - NEUTRAL .4823 Variant of unknown origin 26919320 surgery - NOS NS 43 ENSP00000345973.2:p.Gly221Trp ENST00000344576.6:c.661G>T 7:g.55152578G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-12-0616-01 1910246 1798537 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 36 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51803429 COSM7002279 104567135 c.1280G>A p.R427H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000345973.2:p.Arg427His ENST00000344576.6:c.1280G>A 7:g.55157735G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-246-tumor 2819109 2675408 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-073-tumor 2819009 2675308 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00329T00329 2857335 2712635 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2819307 2819307 2675606 lung left_upper_lobe NS NS carcinoma invasive_mucinous_adenocarcinoma NS NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 30572543 circulating tumour NS 80 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 109600 2812903 2669317 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 46 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-150-tumor 2819055 2675354 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00300T00300 2857355 2712655 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-78-7155-01 1914061 1802343 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51802828 COSM6178056 104595590 c.1296A>T p.Q432H Substitution - Missense 38 7:55157751-55157751 + - PATHOGENIC .9647 Variant of unknown origin 417 fresh/frozen - NOS primary 68 ENSP00000345973.2:p.Gln432His ENST00000344576.6:c.1296A>T 7:g.55157751A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00005T00005 2857374 2712674 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-043-tumor 2818993 2675292 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00296T00296 2857351 2712651 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732920 2732920 2591673 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 104564298 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 73 ENSP00000345973.2:p.Thr263Pro ENST00000344576.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00177T00177 2857368 2712668 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00204T00204 2857356 2712656 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 9VWJAP 2762757 2621016 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51826193 COSM7340403 104570487 c.458A>G p.N153S Substitution - Missense 38 7:55146639-55146639 + - PATHOGENIC .99355 Reported in another cancer sample as somatic 29615459 NS NS 71 ENSP00000345973.2:p.Asn153Ser ENST00000344576.6:c.458A>G 7:g.55146639A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732886 2732886 2591639 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779091 COSM2155593 104568632 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 50 ENSP00000345973.2:p.Thr363Ile ENST00000344576.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732919 2732919 2591672 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 104564298 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 73 ENSP00000345973.2:p.Thr263Pro ENST00000344576.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194729 1194729 1106624 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-103-tumor 2819029 2675328 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2509042 2509042 2371377 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 104564298 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 74 ENSP00000345973.2:p.Thr263Pro ENST00000344576.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0127-01 1910170 1798461 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766389 COSM43067 104576197 c.874G>T p.V292L Substitution - Missense het 38 7:55154137-55154137 + - PATHOGENIC .98997 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 67 ENSP00000345973.2:p.Val292Leu ENST00000344576.6:c.874G>T 7:g.55154137G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-160-tumor 2819059 2675358 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-042-tumor 2818992 2675291 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00331T00331 2857371 2712671 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-104-tumor 2819030 2675329 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-228-tumor 2819103 2675402 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-076-tumor 2819012 2675311 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 109588 2812897 2669311 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 45 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-205-tumor 2819087 2675386 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00332T00332 2857343 2712643 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-099-tumor 2819026 2675325 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-266-tumor 2819117 2675416 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0002PT00013T00013 2857370 2712670 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV99291226 COSM7552389 104576692 c.1124C>T p.A375V Substitution - Missense 38 7:55156650-55156650 + - PATHOGENIC .98971 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Ala375Val ENST00000344576.6:c.1124C>T 7:g.55156650C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SJHYPO052 2301072 2166353 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 104565402 c.1279C>T p.R427C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Reported in another cancer sample as somatic 638 NS NS ENSP00000345973.2:p.Arg427Cys ENST00000344576.6:c.1279C>T 7:g.55157734C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-112-tumor 2819035 2675334 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0157-01 1910184 1798475 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 63 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00221T00221 2857376 2712676 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-027-tumor 2818987 2675286 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0002PT00013T00013 2857370 2712670 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-125-tumor 2819044 2675343 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 109618 2812909 2669323 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 52 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00354T00354 2857354 2712654 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-02-0003-01 1910122 1798413 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51809225 COSM35825 104578101 c.1859G>A p.C620Y Substitution - Missense het 38 7:55165416-55165416 + - PATHOGENIC .99893 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 50 ENSP00000345973.2:p.Cys620Tyr ENST00000344576.6:c.1859G>A 7:g.55165416G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-147-tumor 2819052 2675351 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2855910 2855910 2711313 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV104368998 COSM9232920 104570385 c.886C>T p.P296S Substitution - Missense 38 7:55154149-55154149 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 32269842 surgery-fixed NS 58 ENSP00000345973.2:p.Pro296Ser ENST00000344576.6:c.886C>T 7:g.55154149C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 109590 2812898 2669312 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 56 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732921 2732921 2591674 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 49 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 BL-14-R46791 2905653 2759909 NS NS NS NS malignant_melanoma NS NS NS n COSV51844648 COSM6971178 104566307 c.820A>G p.T274A Substitution - Missense 38 7:55154083-55154083 + - PATHOGENIC .96224 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000345973.2:p.Thr274Ala ENST00000344576.6:c.820A>G 7:g.55154083A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2878966 2878966 2733481 oesophagus NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51813913 COSM6023901 104566020 c.344A>C p.N115T Substitution - Missense 38 7:55143408-55143408 + - PATHOGENIC .92454 Reported in another cancer sample as somatic 33115932 surgery-fixed NS 68 ENSP00000345973.2:p.Asn115Thr ENST00000344576.6:c.344A>C 7:g.55143408A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 BL-16-G30012 2905599 2759855 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51815598 COSM6471954 104570792 c.1325G>T p.S442I Substitution - Missense 38 7:55160165-55160165 + - NEUTRAL .44157 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000345973.2:p.Ser442Ile ENST00000344576.6:c.1325G>T 7:g.55160165G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0002PT00039T00039 2857325 2712625 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-024-tumor 2818985 2675284 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2701162 2701162 2560066 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51822289 COSM42977 104574512 c.315G>T p.Q105H Substitution - Missense het 38 7:55143379-55143379 + - PATHOGENIC .90579 Reported in another cancer sample as somatic 28581676 surgery-fixed NS 41 ENSP00000345973.2:p.Gln105His ENST00000344576.6:c.315G>T 7:g.55143379G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51803429 COSM7002279 104567135 c.1280G>A p.R427H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000345973.2:p.Arg427His ENST00000344576.6:c.1280G>A 7:g.55157735G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00320T00320 2857338 2712638 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-273-tumor 2819121 2675420 meninges NS NS NS meningioma anaplastic NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00357T00357 2857360 2712660 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-023-tumor 2818984 2675283 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-208-tumor 2819090 2675389 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732924 2732924 2591677 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 64 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732935 2732935 2591688 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 72 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-275-tumor 2819122 2675421 meninges NS NS NS meningioma anaplastic NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-38-4627-01 1780091 1684090 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 64 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 BL-16-A36234 2905681 2759937 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2509046 2509046 2371381 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 104562086 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 62 ENSP00000345973.2:p.Pro596Leu ENST00000344576.6:c.1787C>T 7:g.55165344C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00346T00346 2857341 2712641 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00192T00192 2857326 2712626 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 DCR10 1690659 1598936 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 104568799 c.1476C>A p.S492R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000345973.2:p.Ser492Arg ENST00000344576.6:c.1476C>A 7:g.55160316C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-162-tumor 2819060 2675359 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 109598 2812902 2669316 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 44 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00426T00426 2857346 2712646 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 BL-17-G34953 2905427 2759683 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51788796 COSM4680390 104574158 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000345973.2:p.Arg98Gln ENST00000344576.6:c.293G>A 7:g.55143357G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00305T00305 2857328 2712628 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00278T00278 2857364 2712664 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-197-tumor 2819082 2675381 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0002PT00038T00038 2857332 2712632 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 HN_62506 1560544 1481994 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51818237 COSM122787 104583880 c.534G>T p.M178I Substitution - Missense 38 7:55146715-55146715 + - PATHOGENIC .7306 Reported in another cancer sample as somatic 21798893 surgery fresh/frozen primary ENSP00000345973.2:p.Met178Ile ENST00000344576.6:c.534G>T 7:g.55146715G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-46-3769-01 1781825 1685824 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51799159 COSM747427 104574797 c.1766C>T p.P589L Substitution - Missense 38 7:55165323-55165323 + - PATHOGENIC .95834 Reported in another cancer sample as somatic 418 fresh/frozen - NOS primary 57 ENSP00000345973.2:p.Pro589Leu ENST00000344576.6:c.1766C>T 7:g.55165323C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 LUAD-RT-S01810 1765179 1669499 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51809160 COSM382935 104564104 c.1606G>A p.V536M Substitution - Missense 38 7:55161606-55161606 + - PATHOGENIC .98051 Reported in another cancer sample as somatic 22980975 surgery - NOS primary ENSP00000345973.2:p.Val536Met ENST00000344576.6:c.1606G>A 7:g.55161606G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 8LFG8F 2762947 2621206 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51839851 COSM7340115 104576384 c.1118C>A p.P373Q Substitution - Missense 38 7:55156644-55156644 + - PATHOGENIC .76649 Reported in another cancer sample as somatic 29615459 NS metastasis 45 ENSP00000345973.2:p.Pro373Gln ENST00000344576.6:c.1118C>A 7:g.55156644C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 109610 2812911 2669325 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 16 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 5-GE087-T1 2869792 2724789 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51844840 COSM5793412 104581299 c.2014C>T p.P672S Substitution - Missense 38 7:55170440-55170440 + - NEUTRAL .00968 Reported in another cancer sample as somatic 26950094 surgery - NOS NS 80 ENSP00000345973.2:p.Pro672Ser ENST00000344576.6:c.2014C>T 7:g.55170440C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194728 1194728 1106623 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2733228 2733228 2591981 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 104562086 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 61 ENSP00000345973.2:p.Pro596Leu ENST00000344576.6:c.1787C>T 7:g.55165344C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-AP-A0LM-01 1783352 1687351 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51797307 COSM1090871 104572879 c.1310C>A p.S437Y Substitution - Missense het 38 7:55160150-55160150 + - PATHOGENIC .98943 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 33 ENSP00000345973.2:p.Ser437Tyr ENST00000344576.6:c.1310C>A 7:g.55160150C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 DCR7 1690657 1598934 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 104568799 c.1476C>A p.S492R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000345973.2:p.Ser492Arg ENST00000344576.6:c.1476C>A 7:g.55160316C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 B00426 2910515 2764377 ovary NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51792433 COSM6966446 104579842 c.1762G>A p.G588S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Reported in another cancer sample as somatic 33947352 surgery-fixed NS ENSP00000345973.2:p.Gly588Ser ENST00000344576.6:c.1762G>A 7:g.55165319G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00264T00264 2857327 2712627 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-018-tumor 2818983 2675282 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0002PT00015T00015 2857336 2712636 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00226T00226 2857365 2712665 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-185-tumor 2819071 2675370 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-087-tumor 2819019 2675318 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-02-0021-01 1910130 1798421 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 104565122 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 44 ENSP00000345973.2:p.Arg252Cys ENST00000344576.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-171-tumor 2819064 2675363 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 BL-17-J45330 2905663 2759919 NS NS NS NS malignant_melanoma NS NS NS n COSV51777851 COSM1205052 104571359 c.494G>A p.R165Q Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .0375 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000345973.2:p.Arg165Gln ENST00000344576.6:c.494G>A 7:g.55146675G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00240T00240 2857369 2712669 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-083-tumor 2819016 2675315 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-168-tumor 2819062 2675361 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-066-tumor 2819004 2675303 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-AS-3778-01 1779806 1683805 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51831642 COSM1496684 104568540 c.988G>A p.E330K Substitution - Missense 38 7:55155928-55155928 + - PATHOGENIC .94538 Reported in another cancer sample as somatic 416 fresh/frozen - NOS primary 35 ENSP00000345973.2:p.Glu330Lys ENST00000344576.6:c.988G>A 7:g.55155928G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-014-tumor 2818981 2675280 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194730 1194730 1106625 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0154-01 1910182 1798473 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense hom 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 55 ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00227T00227 2857348 2712648 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-111-tumor 2819034 2675333 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00414T00414 2857361 2712661 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-075-tumor 2819011 2675310 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 109596 2812901 2669315 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 72 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0219-01 1910209 1798500 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 67 ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S002024 1027695 944671 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51785554 COSM21688 104562387 c.971G>T p.R324L Substitution - Missense het 38 7:55155911-55155911 + - PATHOGENIC .97287 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Arg324Leu ENST00000344576.6:c.971G>T 7:g.55155911G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00355T00355 2857331 2712631 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-174-tumor 2819067 2675366 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-230-tumor 2819105 2675404 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 ESO-963 1890976 1780345 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV51799199 COSM1251020 104565296 c.1774G>A p.V592I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Reported in another cancer sample as somatic 23525077 surgery fresh/frozen primary 75 ENSP00000345973.2:p.Val592Ile ENST00000344576.6:c.1774G>A 7:g.55165331G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2696524 2696524 2555428 central_nervous_system middle_frontal_gyrus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28201779 surgery fresh/frozen NS 56 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 618-1503-04TD 1921502 1808820 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51797215 COSM145360 104567668 c.967G>A p.V323I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Reported in another cancer sample as somatic 340 blood NS ENSP00000345973.2:p.Val323Ile ENST00000344576.6:c.967G>A 7:g.55155907G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0002PT00018T00018 2857363 2712663 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-121-tumor 2819042 2675341 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-201-tumor 2819084 2675383 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2805811 2805811 2662548 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 31348837 surgery - NOS NS ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194736 1194736 1106631 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2785975 2785975 2643435 large_intestine colon ascending NS carcinoma neuroendocrine_carcinoma NS NS n COSV51781835 COSM174732 104564456 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Reported in another cancer sample as somatic 28730258 surgery-fixed primary 61 ENSP00000345973.2:p.Glu114Lys ENST00000344576.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2733218 2733218 2591971 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 42 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S001005 1027699 944675 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 OX-CO-2_R3_Cetux 2841378 2696927 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 104569429 c.1391C>T p.S464L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000345973.2:p.Ser464Leu ENST00000344576.6:c.1391C>T 7:g.55160231C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SNU-C2B 2302010 2167293 large_intestine colon right NS carcinoma adenocarcinoma NS NS y COSV51777851 COSM1205052 104571359 c.494G>A p.R165Q Substitution - Missense het 38 7:55146675-55146675 + - NEUTRAL .0375 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000345973.2:p.Arg165Gln ENST00000344576.6:c.494G>A 7:g.55146675G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2579398 2579398 2440735 NS NS NS NS malignant_melanoma NS NS NS n COSV51788796 COSM4680390 104574158 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000345973.2:p.Arg98Gln ENST00000344576.6:c.293G>A 7:g.55143357G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00207T00207 2857359 2712659 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194725 1194725 1106620 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 104563335 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Ala289Asp ENST00000344576.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0125-01 1910168 1798459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 64 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S001095 1027691 944667 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-156-tumor 2819056 2675355 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00143T00143 2857358 2712658 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 5-GE101-T1 2869805 2724802 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51822498 COSM3266565 104580564 c.917C>T p.S306L Substitution - Missense 38 7:55155857-55155857 + - PATHOGENIC .98807 Reported in another cancer sample as somatic 26950094 surgery - NOS NS 81 ENSP00000345973.2:p.Ser306Leu ENST00000344576.6:c.917C>T 7:g.55155857C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2579649 2579649 2440986 NS NS NS NS malignant_melanoma NS NS NS n COSV51781835 COSM174732 104564456 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000345973.2:p.Glu114Lys ENST00000344576.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2625627 2625627 2486039 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51767687 COSM6191352 104561335 c.1747G>A p.A583T Substitution - Missense het 38 7:55165304-55165304 + - PATHOGENIC .98656 Reported in another cancer sample as somatic 26488212 surgery-fixed NS ENSP00000345973.2:p.Ala583Thr ENST00000344576.6:c.1747G>A 7:g.55165304G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2808102 2808102 2664786 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 31258848 surgery-fixed NS 60 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732896 2732896 2591649 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 58 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SJHGG120_D 2307435 2172639 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 24705251 surgery - NOS NS 12 ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-02-0089-01 1910158 1798449 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense hom 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 54 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00190T00190 2857342 2712642 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00243T00243 2857340 2712640 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-175-tumor 2819068 2675367 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00383T00383 2857375 2712675 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0237-01 1910211 1798502 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense hom 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 75 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-02-0007-01 1910125 1798416 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 104564298 c.787A>C p.T263P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 42 ENSP00000345973.2:p.Thr263Pro ENST00000344576.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2840788 2840788 2696348 prostate NS NS NS carcinoma NS NS NS n COSV51785413 COSM1176673 104566152 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 31874108 surgery-fixed metastasis ENSP00000345973.2:p.Arg252His ENST00000344576.6:c.755G>A 7:g.55154018G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-RR-A6KC-01 2339255 2204238 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 104565122 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 NS primary 55 ENSP00000345973.2:p.Arg252Cys ENST00000344576.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 HN_62995 1560583 1482033 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825459 COSM122789 104567616 c.1423A>G p.I475V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Reported in another cancer sample as somatic 21798893 surgery fresh/frozen primary ENSP00000345973.2:p.Ile475Val ENST00000344576.6:c.1423A>G 7:g.55160263A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-057-tumor 2818998 2675297 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-078-tumor 2819014 2675313 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-BS-A0UV-01 1783478 1687477 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51773524 COSM1090858 104562705 c.418T>G p.L140V Substitution - Missense het 38 7:55143482-55143482 + - NEUTRAL .25717 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 55 ENSP00000345973.2:p.Leu140Val ENST00000344576.6:c.418T>G 7:g.55143482T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0004119-T01-IM5 2720520 2579341 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 104565122 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg252Cys ENST00000344576.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194737 1194737 1106632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 pros_01_dx 2688203 2547185 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 544 NS primary 41 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-02-0016-01 1910129 1798420 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 50 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-050-tumor 2818996 2675295 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00443T00443 2857349 2712649 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S001067 1027687 944663 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 104564298 c.787A>C p.T263P Substitution - Missense hom 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Thr263Pro ENST00000344576.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0004491-T01-IM5 2720890 2579711 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28481359 surgery - NOS primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 EXTERN_MELA_20140526_088 2839362 2695128 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 104564846 c.1168C>A p.Q390K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000345973.2:p.Gln390Lys ENST00000344576.6:c.1168C>A 7:g.55156793C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 924777 924777 841550 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51863722 COSM13560 104571534 c.1871G>T p.C624F Substitution - Missense het 38 7:55165428-55165428 + - PATHOGENIC .99905 Reported in another cancer sample as somatic 16133419 NS NS ENSP00000345973.2:p.Cys624Phe ENST00000344576.6:c.1871G>T 7:g.55165428G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-08-0380-01 1910239 1798530 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779162 COSM21689 104562086 c.1787C>T p.P596L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 74 ENSP00000345973.2:p.Pro596Leu ENST00000344576.6:c.1787C>T 7:g.55165344C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S003763 1027686 944662 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T155 1861137 1752078 endometrium NS NS NS carcinoma serous_carcinoma NS NS y COSV51785413 COSM1176673 104566152 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 23104009 surgery fresh/frozen primary ENSP00000345973.2:p.Arg252His ENST00000344576.6:c.755G>A 7:g.55154018G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-196-tumor 2819081 2675380 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00237T00237 2857324 2712624 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-070-tumor 2819006 2675305 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00173T00173 2857372 2712672 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S001108 1027693 944669 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 17177598 cell-line NS ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2841857 2841857 2697406 soft_tissue fibrous_tissue_and_uncertain_origin trunk NS desmoid_tumour-fibromatosis NS NS NS n COSV51777833 COSM4680394 104566531 c.1580G>A p.R527Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Reported in another cancer sample as somatic 32099073 surgery-fixed NS 27 ENSP00000345973.2:p.Arg527Gln ENST00000344576.6:c.1580G>A 7:g.55161580G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194731 1194731 1106626 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0649 2107982 1985843 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51791901 COSM2151461 104582224 c.991G>A p.G331R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .96902 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Gly331Arg ENST00000344576.6:c.991G>A 7:g.55155931G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2733227 2733227 2591980 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 104562086 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 61 ENSP00000345973.2:p.Pro596Leu ENST00000344576.6:c.1787C>T 7:g.55165344C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-02-0046-01 1910140 1798431 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 61 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00004T00004 2857337 2712637 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 109594 2812900 2669314 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 66 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MG-198-tumor 2819083 2675382 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00178T00178 2857362 2712662 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PF08 2560049 2421473 large_intestine colon sigmoid NS adenoma tubular NS NS n COSV51779162 COSM21689 104562086 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 27609830 surgery-fixed NS ENSP00000345973.2:p.Pro596Leu ENST00000344576.6:c.1787C>T 7:g.55165344C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 DCR9 1690658 1598935 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 104568799 c.1476C>A p.S492R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000345973.2:p.Ser492Arg ENST00000344576.6:c.1476C>A 7:g.55160316C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732912 2732912 2591665 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 104563335 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 60 ENSP00000345973.2:p.Ala289Asp ENST00000344576.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732923 2732923 2591676 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 64 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732934 2732934 2591687 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 72 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2840787 2840787 2696347 prostate NS NS NS carcinoma NS NS NS n COSV51785413 COSM1176673 104566152 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000345973.2:p.Arg252His ENST00000344576.6:c.755G>A 7:g.55154018G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PD_06 2688647 2547629 skin face NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51852113 COSM4501266 104570275 c.584C>T p.P195L Substitution - Missense het 38 7:55151318-55151318 + - NEUTRAL .31382 Confirmed somatic variant 24662767 surgery fresh/frozen NS 75 ENSP00000345973.2:p.Pro195Leu ENST00000344576.6:c.584C>T 7:g.55151318C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CSCC-40-T 2292477 2158541 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51858853 COSM4512041 104589063 c.889C>T p.R297C Substitution - Missense het 38 7:55154152-55154152 + - PATHOGENIC .97012 Confirmed somatic variant 25303977 surgery fresh/frozen metastasis 49 ENSP00000345973.2:p.Arg297Cys ENST00000344576.6:c.889C>T 7:g.55154152C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2732925 2732925 2591678 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 75 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2585421 2585421 2446585 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576891 COSM9396331 104569240 c.1400A>C p.K467T Substitution - Missense het 38 7:55160240-55160240 + - NEUTRAL .10442 Reported in another cancer sample as somatic 25623215 surgery - NOS recurrent ENSP00000345973.2:p.Lys467Thr ENST00000344576.6:c.1400A>C 7:g.55160240A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DU-7012-01 2194261 2062539 central_nervous_system brain NS NS glioma NS NS NS y COSV51774829 COSM1451549 104563113 c.767A>G p.D256G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 545 NS NS 74 ENSP00000345973.2:p.Asp256Gly ENST00000344576.6:c.767A>G 7:g.55154030A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194738 1194738 1106633 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 112509 1520625 1443000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51833788 COSM94181 104588617 c.1675C>T p.H559Y Substitution - Missense 38 7:55163776-55163776 + - PATHOGENIC .97598 Confirmed somatic variant 20668451 NS primary ENSP00000345973.2:p.His559Tyr ENST00000344576.6:c.1675C>T 7:g.55163776C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GBM19-I1 2813465 2669857 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GB013T 2633978 2494374 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51855854 COSM6355744 104582550 c.977G>T p.C326F Substitution - Missense 38 7:55155917-55155917 + - PATHOGENIC .99445 Confirmed somatic variant 672 NS primary ENSP00000345973.2:p.Cys326Phe ENST00000344576.6:c.977G>T 7:g.55155917G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 U373 2491105 2353751 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51804471 COSM5712404 104596378 c.1523C>T p.A508V Substitution - Missense 38 7:55161523-55161523 + - NEUTRAL .21884 Confirmed somatic variant 26496030 cell-line NS ENSP00000345973.2:p.Ala508Val ENST00000344576.6:c.1523C>T 7:g.55161523C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0007024-T01-IM5 2723398 2582219 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51786507 COSM6955643 104581635 c.1118C>T p.P373L Substitution - Missense het 38 7:55156644-55156644 + - PATHOGENIC .86501 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Pro373Leu ENST00000344576.6:c.1118C>T 7:g.55156644C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0007024-T01-IM5 2723398 2582219 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GBM13-I3 2813477 2669869 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28263318 surgery fresh/frozen NS 55 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 5-VS033-T2 2869855 2724852 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105111133 COSM9656692 104591038 c.2014_2015delinsTT p.P672F Substitution - Missense 38 7:55170440-55170441 + - Confirmed somatic variant 26950094 surgery - NOS NS 73 ENSP00000345973.2:p.Pro672Phe ENST00000344576.6:c.2014_2015delinsTT 7:g.55170440_55170441delinsTT EGFR_ENST00000344576 ENST00000344576.6 2118 3236 5-VS033-T2 2869855 2724852 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51790737 COSM3639739 104589426 c.1621C>T p.L541F Substitution - Missense 38 7:55161621-55161621 + - NEUTRAL .0484 Confirmed somatic variant 26950094 surgery - NOS NS 73 ENSP00000345973.2:p.Leu541Phe ENST00000344576.6:c.1621C>T 7:g.55161621C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 5-VS033-T2 2869855 2724852 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51776559 COSM4892884 104565414 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 26950094 surgery - NOS NS 73 ENSP00000345973.2:p.Pro100Ser ENST00000344576.6:c.298C>T 7:g.55143362C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2841184 2841184 2696744 prostate NS NS NS carcinoma NS NS NS n COSV104577128 COSM9497116 104591153 c.1471A>G p.I491V Substitution - Missense 38 7:55160311-55160311 + - NEUTRAL .12941 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000345973.2:p.Ile491Val ENST00000344576.6:c.1471A>G 7:g.55160311A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 NPC0001PT00407T00407 2857330 2712630 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GB051T 2634016 2494412 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51846086 COSM6354719 104592927 c.178G>A p.V60M Substitution - Missense 38 7:55142375-55142375 + - PATHOGENIC .96004 Confirmed somatic variant 672 NS primary ENSP00000345973.2:p.Val60Met ENST00000344576.6:c.178G>A 7:g.55142375G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-AP-A051-01 1783330 1687329 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51837186 COSM1090861 104568806 c.442G>A p.V148M Substitution - Missense het 38 7:55146623-55146623 + - PATHOGENIC .99004 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 69 ENSP00000345973.2:p.Val148Met ENST00000344576.6:c.442G>A 7:g.55146623G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S004384 1027694 944670 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MSU2-a 2809971 2666633 large_intestine caecum NS NS adenoma villous NS NS y COSV51784286 COSM6652281 104566350 c.116C>T p.T39M Substitution - Missense 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000345973.2:p.Thr39Met ENST00000344576.6:c.116C>T 7:g.55142313C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0012113-T01-IM5 2727253 2586074 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51851189 COSM6982714 104569841 c.1405T>G p.L469V Substitution - Missense het 38 7:55160245-55160245 + - NEUTRAL .32338 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Leu469Val ENST00000344576.6:c.1405T>G 7:g.55160245T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-14-0813-01 1337991 1248376 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779162 COSM21689 104562086 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 329 surgery fresh/frozen NS 78 ENSP00000345973.2:p.Pro596Leu ENST00000344576.6:c.1787C>T 7:g.55165344C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 400_R4 2910227 2764189 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV104577128 COSM9497116 104591153 c.1471A>G p.I491V Substitution - Missense het 38 7:55160311-55160311 + - NEUTRAL .12941 Confirmed somatic variant 27639803 short-term culture NS 69 ENSP00000345973.2:p.Ile491Val ENST00000344576.6:c.1471A>G 7:g.55160311A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 ESCC_35 2479543 2342303 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51774192 COSM5628704 104585013 c.596G>C p.C199S Substitution - Missense 38 7:55151330-55151330 + - PATHOGENIC .99573 Confirmed somatic variant 26873401 NS NS 68 ENSP00000345973.2:p.Cys199Ser ENST00000344576.6:c.596G>C 7:g.55151330G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GB057T 2634022 2494418 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 672 NS primary ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-FG-6692-01 2194411 2062689 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 63 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 non-ocular_carcinoma_3 2580640 2441977 skin neck NS NS adnexal_tumour sebaceous_carcinoma NS NS n COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 27287813 surgery-fixed primary ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-16-1045-01 1338027 1248412 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 104564298 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 surgery fresh/frozen NS 49 ENSP00000345973.2:p.Thr263Pro ENST00000344576.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DF-A2L0-01 2457392 2320229 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51809160 COSM382935 104564104 c.1606G>A p.V536M Substitution - Missense 38 7:55161606-55161606 + - PATHOGENIC .98051 Confirmed somatic variant 419 NS primary 60 ENSP00000345973.2:p.Val536Met ENST00000344576.6:c.1606G>A 7:g.55161606G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2876663 2876663 2731178 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 surgery fresh/frozen NS 60 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0000677-T01-IM3 2715765 2574586 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51860516 COSM6911906 104574187 c.1143C>G p.F381L Substitution - Missense het 38 7:55156768-55156768 + - PATHOGENIC .96387 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Phe381Leu ENST00000344576.6:c.1143C>G 7:g.55156768C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 ICGC_GBM53_tumor 2634861 2495257 central_nervous_system brain NS NS primitive_neuroectodermal_tumour-medulloblastoma NS NS NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 379 NS primary 5 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51807036 COSM2151966 104569075 c.1787C>G p.P596R Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99615 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000345973.2:p.Pro596Arg ENST00000344576.6:c.1787C>G 7:g.55165344C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 104563335 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000345973.2:p.Ala289Asp ENST00000344576.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0013374-T01-IM5 2803847 2660597 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51793336 COSM6214981 104582035 c.1663T>C p.C555R Substitution - Missense het 38 7:55163764-55163764 + - PATHOGENIC .99407 Confirmed somatic variant 29316426 surgery-fixed primary 79 ENSP00000345973.2:p.Cys555Arg ENST00000344576.6:c.1663T>C 7:g.55163764T>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009856-T01-IM5 2725695 2584516 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51844648 COSM6971178 104566307 c.820A>G p.T274A Substitution - Missense het 38 7:55154083-55154083 + - PATHOGENIC .96224 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000345973.2:p.Thr274Ala ENST00000344576.6:c.820A>G 7:g.55154083A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-12-3652-01 2120285 1994521 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51800797 COSM3412178 104567250 c.755G>C p.R252P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 329 NS NS 60 ENSP00000345973.2:p.Arg252Pro ENST00000344576.6:c.755G>C 7:g.55154018G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 004 2492942 2355556 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour benign NS n COSV51768130 COSM21684 104564298 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 26437033 NS NS ENSP00000345973.2:p.Thr263Pro ENST00000344576.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003104-T01-IM5 2719600 2578421 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51779162 COSM21689 104562086 c.1787C>T p.P596L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Pro596Leu ENST00000344576.6:c.1787C>T 7:g.55165344C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003360-T01-IM5 2719851 2578672 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0749-01 1337861 1248246 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849240 COSM6923103 104564991 c.1759G>A p.D587N Substitution - Missense het 38 7:55165316-55165316 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Asp587Asn ENST00000344576.6:c.1759G>A 7:g.55165316G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849279 COSM6923107 104565013 c.1770C>A p.H590Q Substitution - Missense het 38 7:55165327-55165327 + - PATHOGENIC .98427 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.His590Gln ENST00000344576.6:c.1770C>A 7:g.55165327C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849201 COSM6923099 104564968 c.1331A>T p.N444I Substitution - Missense het 38 7:55160171-55160171 + - PATHOGENIC .8398 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Asn444Ile ENST00000344576.6:c.1331A>T 7:g.55160171A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-19-2620-01 2120303 1994539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 70 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S02279_1 2480887 2343632 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV51810698 COSM5683869 104578723 c.1337C>A p.T446K Substitution - Missense 38 7:55160177-55160177 + - NEUTRAL .09422 Confirmed somatic variant 26168399 surgery fresh/frozen primary 58 ENSP00000345973.2:p.Thr446Lys ENST00000344576.6:c.1337C>A 7:g.55160177C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0004971-T01-IM5 2721381 2580202 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PD6907a 1504118 1426996 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51857264 COSM4384115 104587489 c.727C>T p.P243S Substitution - Missense 38 7:55152644-55152644 + - PATHOGENIC .99273 Confirmed somatic variant 24030381 NS NS ENSP00000345973.2:p.Pro243Ser ENST00000344576.6:c.727C>T 7:g.55152644C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 R098-I1 2813503 2669895 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 104564353 c.809A>G p.Y270C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 28263318 surgery fresh/frozen NS 51 ENSP00000345973.2:p.Tyr270Cys ENST00000344576.6:c.809A>G 7:g.55154072A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-FP-7829-01 2198081 2066359 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51829933 COSM3881812 104573373 c.971G>A p.R324H Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .95186 Confirmed somatic variant 541 NS NS 69 ENSP00000345973.2:p.Arg324His ENST00000344576.6:c.971G>A 7:g.55155911G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P162 2072615 1951970 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51776043 COSM54529 104564835 c.1957A>T p.S653C Substitution - Missense 38 7:55170383-55170383 + - NEUTRAL .01222 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 47 ENSP00000345973.2:p.Ser653Cys ENST00000344576.6:c.1957A>T 7:g.55170383A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GBM19-I2 2813466 2669858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0004846-T01-IM5 2721249 2580070 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51779091 COSM2155593 104568632 c.1088C>T p.T363I Substitution - Missense het 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Thr363Ile ENST00000344576.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-D8-A1JF-01 1900052 1788736 breast NS NS NS carcinoma NS NS NS y COSV51781835 COSM174732 104564456 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 414 fresh/frozen - NOS primary 79 ENSP00000345973.2:p.Glu114Lys ENST00000344576.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0014258-T01-IM6 2803906 2660656 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51826193 COSM7340403 104570487 c.458A>G p.N153S Substitution - Missense het 38 7:55146639-55146639 + - PATHOGENIC .99355 Confirmed somatic variant 29316426 surgery-fixed primary 69 ENSP00000345973.2:p.Asn153Ser ENST00000344576.6:c.458A>G 7:g.55146639A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 LC_S35 1863746 1754637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 22975805 surgery fresh/frozen primary 82 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003222-T01-IM5 2719716 2578537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51841941 COSM6927106 104563584 c.846G>T p.E282D Substitution - Missense het 38 7:55154109-55154109 + - NEUTRAL .06117 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000345973.2:p.Glu282Asp ENST00000344576.6:c.846G>T 7:g.55154109G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-19-1789 2108040 1985901 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51850088 COSM2156010 104574771 c.1000C>T p.R334C Substitution - Missense 38 7:55155940-55155940 + - PATHOGENIC .91604 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Arg334Cys ENST00000344576.6:c.1000C>T 7:g.55155940C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006399-T01-IM5 2722775 2581596 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843352 COSM6950555 104581218 c.530C>T p.S177L Substitution - Missense het 38 7:55146711-55146711 + - NEUTRAL .28714 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Ser177Leu ENST00000344576.6:c.530C>T 7:g.55146711C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-02-0003 2107930 1985791 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51809225 COSM35825 104578101 c.1859G>A p.C620Y Substitution - Missense 38 7:55165416-55165416 + - PATHOGENIC .99893 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Cys620Tyr ENST00000344576.6:c.1859G>A 7:g.55165416G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0000906-T01-IM3 2716233 2575054 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765787 COSM2149971 104564009 c.910C>T p.H304Y Substitution - Missense het 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.His304Tyr ENST00000344576.6:c.910C>T 7:g.55155850C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 LICA-CN-HCC089T 2634136 2494532 liver NS NS NS other neoplasm NS NS y COSV51832020 COSM5822378 104579500 c.1742A>T p.Q581L Substitution - Missense 38 7:55165299-55165299 + - PATHOGENIC .9451 Confirmed somatic variant 660 NS primary 48 ENSP00000345973.2:p.Gln581Leu ENST00000344576.6:c.1742A>T 7:g.55165299A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-QH-A6CX-01 2263100 2130084 central_nervous_system brain NS NS glioma NS NS NS y COSV51785554 COSM21688 104562387 c.971G>T p.R324L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 545 NS primary 66 ENSP00000345973.2:p.Arg324Leu ENST00000344576.6:c.971G>T 7:g.55155911G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-AO-A12G-01 1899795 1788479 breast NS NS NS carcinoma NS NS NS y COSV51772564 COSM453241 104572346 c.817A>G p.T273A Substitution - Missense 38 7:55154080-55154080 + - PATHOGENIC .94785 Confirmed somatic variant 414 fresh/frozen - NOS primary 75 ENSP00000345973.2:p.Thr273Ala ENST00000344576.6:c.817A>G 7:g.55154080A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MSU3-a 2809972 2666634 large_intestine colon transverse NS adenoma tubulovillous NS NS y COSV99292326 COSM9176305 104577849 c.1579C>T p.R527W Substitution - Missense 38 7:55161579-55161579 + - NEUTRAL .28879 Confirmed somatic variant 26336987 surgery fresh/frozen primary 51 ENSP00000345973.2:p.Arg527Trp ENST00000344576.6:c.1579C>T 7:g.55161579C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2014_Lung_sq_25_T 2744896 2603599 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 74 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MTP18_T1 2875797 2730359 pancreas NS NS NS other dysplasia-in_situ_neoplasm NS NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 32796935 surgery-fixed NS 74 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0001171-T01-IM3 2716747 2575568 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51850219 COSM6915112 104566282 c.1846G>T p.V616L Substitution - Missense het 38 7:55165403-55165403 + - PATHOGENIC .98789 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Val616Leu ENST00000344576.6:c.1846G>T 7:g.55165403G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0008258-T01-IM5 2724397 2583218 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-05-4382-01 1780053 1684052 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99288202 COSM7821254 104573307 c.1633G>C p.E545Q Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9875 Confirmed somatic variant 417 fresh/frozen - NOS primary 68 ENSP00000345973.2:p.Glu545Gln ENST00000344576.6:c.1633G>C 7:g.55163734G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-05-4382-01 1780053 1684052 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99288189 COSM7821080 104573282 c.665G>T p.R222L Substitution - Missense 38 7:55152582-55152582 + - PATHOGENIC .99698 Confirmed somatic variant 417 fresh/frozen - NOS primary 68 ENSP00000345973.2:p.Arg222Leu ENST00000344576.6:c.665G>T 7:g.55152582G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-2565 2108006 1985867 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DU-8162-01 2194248 2062526 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 61 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GBM_IV-39 2354294 2218452 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51778955 COSM4967262 104572451 c.680C>A p.S227Y Substitution - Missense 38 7:55152597-55152597 + - NEUTRAL .32595 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000345973.2:p.Ser227Tyr ENST00000344576.6:c.680C>A 7:g.55152597C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0002599-T01-IM3 2718855 2577676 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51832234 COSM6923248 104592221 c.1532C>A p.S511Y Substitution - Missense het 38 7:55161532-55161532 + - PATHOGENIC .99176 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ser511Tyr ENST00000344576.6:c.1532C>A 7:g.55161532C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-E1-A7YM-01 2457423 2320260 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 63 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-HT-A61C-01 2386268 2249100 central_nervous_system brain NS NS glioma NS NS NS y COSV51768130 COSM21684 104564298 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 545 NS primary 66 ENSP00000345973.2:p.Thr263Pro ENST00000344576.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009327-T01-IM5 2725273 2584094 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0005127-T02-IM5 2721531 2580352 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51794869 COSM4362780 104563015 c.574C>T p.P192S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Pro192Ser ENST00000344576.6:c.574C>T 7:g.55151308C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0005127-T02-IM5 2721531 2580352 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51802355 COSM6941144 104563038 c.1154C>T p.P385L Substitution - Missense het 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Pro385Leu ENST00000344576.6:c.1154C>T 7:g.55156779C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0010613-T01-IM5 2726312 2585133 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194722 1194722 1106617 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51824149 COSM29338 104563245 c.178G>C p.V60L Substitution - Missense 38 7:55142375-55142375 + - PATHOGENIC .98023 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Val60Leu ENST00000344576.6:c.178G>C 7:g.55142375G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003128-T01-IM5 2719622 2578443 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 Br001X 1312986 1223895 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51797037 COSM40998 104592996 c.1804G>C p.E602Q Substitution - Missense hom 38 7:55165361-55165361 + - PATHOGENIC .99549 Confirmed somatic variant 18772396 xenograft primary 4 ENSP00000345973.2:p.Glu602Gln ENST00000344576.6:c.1804G>C 7:g.55165361G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-ER-A19E-06 2121716 1995952 skin NS NS NS malignant_melanoma NS NS NS y COSV51817262 COSM3639733 104591232 c.955G>A p.E319K Substitution - Missense 38 7:55155895-55155895 + - PATHOGENIC .99356 Confirmed somatic variant 540 NS NS 36 ENSP00000345973.2:p.Glu319Lys ENST00000344576.6:c.955G>A 7:g.55155895G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 YUKAT 2439331 2302172 skin NS NS NS malignant_melanoma NS NS NS y COSV51838161 COSM5407720 104563434 c.994C>T p.P332S Substitution - Missense het 38 7:55155934-55155934 + - PATHOGENIC .91925 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 78 ENSP00000345973.2:p.Pro332Ser ENST00000344576.6:c.994C>T 7:g.55155934C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-VM-A8CD-01 2262980 2129964 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS primary 58 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-VM-A8CD-01 2262980 2129964 central_nervous_system brain NS NS glioma NS NS NS y COSV99295978 COSM8269849 104581337 c.1747G>T p.A583S Substitution - Missense 38 7:55165304-55165304 + - PATHOGENIC .98882 Confirmed somatic variant 545 NS primary 58 ENSP00000345973.2:p.Ala583Ser ENST00000344576.6:c.1747G>T 7:g.55165304G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-BR-4184-01 2198083 2066361 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51818237 COSM122787 104583880 c.534G>T p.M178I Substitution - Missense 38 7:55146715-55146715 + - PATHOGENIC .7306 Confirmed somatic variant 541 NS NS 70 ENSP00000345973.2:p.Met178Ile ENST00000344576.6:c.534G>T 7:g.55146715G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51792433 COSM6966446 104579842 c.1762G>A p.G588S Substitution - Missense het 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Gly588Ser ENST00000344576.6:c.1762G>A 7:g.55165319G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S001090 1027692 944668 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-14-1034-01 2178234 2046532 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51775191 COSM1451530 104563232 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 329 NS NS 60 ENSP00000345973.2:p.Gly63Arg ENST00000344576.6:c.187G>A 7:g.55142384G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-CG-5721-01 2198017 2066295 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51782832 COSM3881808 104580663 c.739G>A p.D247N Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .98807 Confirmed somatic variant 541 NS NS 58 ENSP00000345973.2:p.Asp247Asn ENST00000344576.6:c.739G>A 7:g.55152656G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 Br230T 1313049 1223958 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 surgery - NOS primary 46 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 13T 2139248 2008776 upper_aerodigestive_tract mouth gingiva NS carcinoma squamous_cell_carcinoma NS NS y COSV51815394 COSM3715755 104566674 c.738C>A p.S246R Substitution - Missense 38 7:55152655-55152655 + - NEUTRAL .15461 Confirmed somatic variant 24292195 NS NS ENSP00000345973.2:p.Ser246Arg ENST00000344576.6:c.738C>A 7:g.55152655C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0005400-T01-IM5 2721802 2580623 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51781835 COSM174732 104564456 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000345973.2:p.Glu114Lys ENST00000344576.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009357-T01-IM5 2725300 2584121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PD25645c 2843020 2698474 skin mucosal sinonasal NS malignant_melanoma NS NS NS y COSV104576411 COSM9505912 104595623 c.881A>T p.K294M Substitution - Missense 38 7:55154144-55154144 + - PATHOGENIC .88176 Confirmed somatic variant 30664638 surgery-fixed primary 58 ENSP00000345973.2:p.Lys294Met ENST00000344576.6:c.881A>T 7:g.55154144A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-22-4609-01 2195227 2063505 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51827895 COSM3412174 104564425 c.685A>T p.S229C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 418 NS NS 81 ENSP00000345973.2:p.Ser229Cys ENST00000344576.6:c.685A>T 7:g.55152602A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009527-T01-IM5 2725444 2584265 skin NS NS NS malignant_melanoma NS NS NS n COSV51794946 COSM6969229 104562517 c.353_354delinsTT p.A118V Substitution - Missense het 38 7:55143417-55143418 + - Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Ala118Val ENST00000344576.6:c.353_354delinsTT 7:g.55143417_55143418delinsTT EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PD4975a 1463682 1387534 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV51844840 COSM5793412 104581299 c.2014C>T p.P672S Substitution - Missense 38 7:55170440-55170440 + - NEUTRAL .00968 Confirmed somatic variant 652 NS primary ENSP00000345973.2:p.Pro672Ser ENST00000344576.6:c.2014C>T 7:g.55170440C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194727 1194727 1106622 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-FS-A1ZK-06 2121762 1995998 skin NS NS NS malignant_melanoma NS NS NS y COSV51790737 COSM3639739 104589426 c.1621C>T p.L541F Substitution - Missense 38 7:55161621-55161621 + - NEUTRAL .0484 Confirmed somatic variant 540 NS NS 68 ENSP00000345973.2:p.Leu541Phe ENST00000344576.6:c.1621C>T 7:g.55161621C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-26-1439 2108054 1985915 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-GN-A8LN-01 2339478 2204461 skin NS NS NS malignant_melanoma NS NS NS y COSV99295991 COSM7976081 104579364 c.1135G>A p.D379N Substitution - Missense 38 7:55156760-55156760 + - PATHOGENIC .99676 Confirmed somatic variant 540 NS primary 68 ENSP00000345973.2:p.Asp379Asn ENST00000344576.6:c.1135G>A 7:g.55156760G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-GN-A8LN-01 2339478 2204461 skin NS NS NS malignant_melanoma NS NS NS y COSV99295987 COSM7976353 104579338 c.815C>T p.P272L Substitution - Missense 38 7:55154078-55154078 + - PATHOGENIC .98876 Confirmed somatic variant 540 NS primary 68 ENSP00000345973.2:p.Pro272Leu ENST00000344576.6:c.815C>T 7:g.55154078C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2492702 2492702 2355317 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 104574373 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000345973.2:p.His47Tyr ENST00000344576.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0747-01 1337860 1248245 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 53 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T341 2658331 2518490 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51784286 COSM6652281 104566350 c.116C>T p.T39M Substitution - Missense 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 27149842 NS NS 66.58 ENSP00000345973.2:p.Thr39Met ENST00000344576.6:c.116C>T 7:g.55142313C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-CV-7250-01 2193784 2062062 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51827895 COSM3412174 104564425 c.685A>T p.S229C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 627 NS NS 64 ENSP00000345973.2:p.Ser229Cys ENST00000344576.6:c.685A>T 7:g.55152602A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0010004-T01-IM5 2725823 2584644 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 W16T 2745047 2603750 thyroid NS NS NS carcinoma NS NS NS y COSV51794993 COSM6399094 104571116 c.5G>A p.R2Q Substitution - Missense 38 7:55019282-55019282 + - NEUTRAL .46409 Confirmed somatic variant 676 NS primary 40 ENSP00000345973.2:p.Arg2Gln ENST00000344576.6:c.5G>A 7:g.55019282G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2011-2283:2012-316-T 2297701 2163302 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51817336 COSM4604310 104589182 c.1376G>C p.G459A Substitution - Missense hom 38 7:55160216-55160216 + - PATHOGENIC .99469 Confirmed somatic variant 25056374 surgery-fixed NS ENSP00000345973.2:p.Gly459Ala ENST00000344576.6:c.1376G>C 7:g.55160216G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-S9-A7R2-01 2263272 2130256 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 69 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2857119 2857119 2712419 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV105110043 COSM9533927 104584540 c.175G>A p.E59K Substitution - Missense 38 7:55142372-55142372 + - PATHOGENIC .93877 Confirmed somatic variant 25096233 surgery - NOS NS ENSP00000345973.2:p.Glu59Lys ENST00000344576.6:c.175G>A 7:g.55142372G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-81-5910-01 2120398 1994634 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 104565122 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 NS NS 64 ENSP00000345973.2:p.Arg252Cys ENST00000344576.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-QB-AA9O-06 2339489 2204472 skin NS NS NS malignant_melanoma NS NS NS y COSV51785510 COSM6957413 104561393 c.1102G>A p.D368N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 540 NS NS 73 ENSP00000345973.2:p.Asp368Asn ENST00000344576.6:c.1102G>A 7:g.55156628G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0001582-T01-IM3 2717588 2576409 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769747 COSM297803 104579537 c.907G>C p.D303H Substitution - Missense het 38 7:55155847-55155847 + - PATHOGENIC .99461 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Asp303His ENST00000344576.6:c.907G>C 7:g.55155847G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S001092 1027684 944660 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2733978 2733978 2592705 soft_tissue fat NS NS liposarcoma NS NS NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 29731991 surgery-fixed recurrent ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 B42-S1 2732496 2591261 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV104576683 COSM9498592 104577590 c.958G>C p.E320Q Substitution - Missense 38 7:55155898-55155898 + - PATHOGENIC .98914 Confirmed somatic variant 29244145 surgery fresh/frozen primary 70.1 ENSP00000345973.2:p.Glu320Gln ENST00000344576.6:c.958G>C 7:g.55155898G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 DD282_Org 2749235 2607934 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51784286 COSM6652281 104566350 c.116C>T p.T39M Substitution - Missense het 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 29703791 organoid culture primary 81 ENSP00000345973.2:p.Thr39Met ENST00000344576.6:c.116C>T 7:g.55142313C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SJHGG029_R 2307362 2172566 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 24705251 surgery - NOS recurrent 4 ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T1196 2658782 2518941 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51797600 COSM5575629 104574140 c.391G>A p.G131R Substitution - Missense 38 7:55143455-55143455 + - PATHOGENIC .99768 Confirmed somatic variant 27149842 NS NS 70.83 ENSP00000345973.2:p.Gly131Arg ENST00000344576.6:c.391G>A 7:g.55143455G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0008346-T01-IM5 2787024 2644447 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51838649 COSM6962468 104583035 c.412A>G p.R138G Substitution - Missense hom 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000345973.2:p.Arg138Gly ENST00000344576.6:c.412A>G 7:g.55143476A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0007771-T01-IM5 2724004 2582825 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51862622 COSM6959670 104561723 c.1322T>G p.V441G Substitution - Missense het 38 7:55160162-55160162 + - PATHOGENIC .9258 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Val441Gly ENST00000344576.6:c.1322T>G 7:g.55160162T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 ccRCC-90 1980826 1867072 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51815313 COSM1661639 104584870 c.673G>T p.G225C Substitution - Missense 38 7:55152590-55152590 + - PATHOGENIC .99717 Confirmed somatic variant 23797736 NS NS ENSP00000345973.2:p.Gly225Cys ENST00000344576.6:c.673G>T 7:g.55152590G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-CD-A4MI-01 2198040 2066318 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51771322 COSM3881814 104569660 c.1051A>G p.I351V Substitution - Missense 38 7:55156577-55156577 + - PATHOGENIC .89527 Confirmed somatic variant 541 NS NS 62 ENSP00000345973.2:p.Ile351Val ENST00000344576.6:c.1051A>G 7:g.55156577A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CRC403 2730857 2589626 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105863818 COSM10064830 104568614 c.1061C>T p.T354M Substitution - Missense 38 7:55156587-55156587 + - PATHOGENIC .97048 Confirmed somatic variant 26416732 xenograft metastasis ENSP00000345973.2:p.Thr354Met ENST00000344576.6:c.1061C>T 7:g.55156587C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194734 1194734 1106629 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-19-2621-01 2178211 2046509 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51863722 COSM13560 104571534 c.1871G>T p.C624F Substitution - Missense 38 7:55165428-55165428 + - PATHOGENIC .99905 Confirmed somatic variant 329 NS NS 83 ENSP00000345973.2:p.Cys624Phe ENST00000344576.6:c.1871G>T 7:g.55165428G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-12-0657-01 2178279 2046577 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99286086 COSM7481785 104583966 c.133G>A p.E45K Substitution - Missense 38 7:55142330-55142330 + - PATHOGENIC .99554 Confirmed somatic variant 329 NS NS 69 ENSP00000345973.2:p.Glu45Lys ENST00000344576.6:c.133G>A 7:g.55142330G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DU-6410-01 2194391 2062669 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 56 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PL9 2492972 2355586 breast NS NS NS carcinoma lobular_carcinoma pleomorphic NS y COSV105110769 COSM9569122 104590953 c.212A>C p.Q71P Substitution - Missense 38 7:55142409-55142409 + - PATHOGENIC .94041 Confirmed somatic variant 26907767 surgery fresh/frozen primary ENSP00000345973.2:p.Gln71Pro ENST00000344576.6:c.212A>C 7:g.55142409A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 W016-S1 2732510 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51785510 COSM6957413 104561393 c.1102G>A p.D368N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000345973.2:p.Asp368Asn ENST00000344576.6:c.1102G>A 7:g.55156628G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 W016-S1 2732510 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T2413 2658547 2518706 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51841802 COSM6652265 104563524 c.2065C>T p.L689F Substitution - Missense 38 7:55170491-55170491 + - NEUTRAL .01022 Confirmed somatic variant 27149842 NS NS 56.16 ENSP00000345973.2:p.Leu689Phe ENST00000344576.6:c.2065C>T 7:g.55170491C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 5-VS072-T1 2869906 2724903 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105111246 COSM9805555 104596605 c.1966C>T p.H656Y Substitution - Missense 38 7:55170392-55170392 + - NEUTRAL .00605 Confirmed somatic variant 26950094 surgery - NOS NS 89 ENSP00000345973.2:p.His656Tyr ENST00000344576.6:c.1966C>T 7:g.55170392C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 EXTERN_MELA_20140524_012 2839317 2695083 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 104565424 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000345973.2:p.Ser116Phe ENST00000344576.6:c.347C>T 7:g.55143411C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 EXTERN_MELA_20140524_012 2839317 2695083 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51776559 COSM4892884 104565414 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000345973.2:p.Pro100Ser ENST00000344576.6:c.298C>T 7:g.55143362C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 YUFARCI 2013606 1896238 skin NS NS NS malignant_melanoma NS NS NS y COSV51816429 COSM1698693 104569289 c.1810A>G p.N604D Substitution - Missense het 38 7:55165367-55165367 + - NEUTRAL .4812 Confirmed somatic variant 22842228 NS NS ENSP00000345973.2:p.Asn604Asp ENST00000344576.6:c.1810A>G 7:g.55165367A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006363-T01-IM5 2722740 2581561 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 104563335 c.866C>A p.A289D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Ala289Asp ENST00000344576.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006363-T01-IM5 2722740 2581561 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-YG-AA3N-01 2339750 2204733 skin NS NS NS malignant_melanoma NS NS NS y COSV51794869 COSM4362780 104563015 c.574C>T p.P192S Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 540 NS primary 67 ENSP00000345973.2:p.Pro192Ser ENST00000344576.6:c.574C>T 7:g.55151308C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0002022-T01-IM3 2718329 2577150 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 104565122 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg252Cys ENST00000344576.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2696712 2696712 2555616 oesophagus NS NS NS other metaplasia epidermoid NS n COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28731047 surgery-fixed primary 65 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PT36 2521293 2383636 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV51784241 COSM5915646 104582961 c.1190C>T p.T397I Substitution - Missense 38 7:55156815-55156815 + - PATHOGENIC .99038 Confirmed somatic variant 25759019 surgery fresh/frozen NS ENSP00000345973.2:p.Thr397Ile ENST00000344576.6:c.1190C>T 7:g.55156815C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 16 2630307 2490691 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51780760 COSM6196858 104575921 c.341A>G p.E114G Substitution - Missense 38 7:55143405-55143405 + - PATHOGENIC .99844 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000345973.2:p.Glu114Gly ENST00000344576.6:c.341A>G 7:g.55143405A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006368-T01-IM5 2722745 2581566 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51843325 COSM6950386 104581200 c.1102G>T p.D368Y Substitution - Missense het 38 7:55156628-55156628 + - PATHOGENIC .97349 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Asp368Tyr ENST00000344576.6:c.1102G>T 7:g.55156628G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-12-0691-01 2178100 2046398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774829 COSM1451549 104563113 c.767A>G p.D256G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 329 NS NS 63 ENSP00000345973.2:p.Asp256Gly ENST00000344576.6:c.767A>G 7:g.55154030A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-BB-8596-01 2193542 2061820 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99289667 COSM8311578 104583557 c.1507G>A p.G503S Substitution - Missense 38 7:55161507-55161507 + - NEUTRAL .07845 Confirmed somatic variant 627 NS NS 69 ENSP00000345973.2:p.Gly503Ser ENST00000344576.6:c.1507G>A 7:g.55161507G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0002105-T01-IM3 2718403 2577224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51844520 COSM6920741 104575484 c.639C>G p.I213M Substitution - Missense het 38 7:55152556-55152556 + - PATHOGENIC .89498 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Ile213Met ENST00000344576.6:c.639C>G 7:g.55152556C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0155 2107953 1985814 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 104564009 c.910C>T p.H304Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.His304Tyr ENST00000344576.6:c.910C>T 7:g.55155850C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0000378-T01-IM3 2715158 2573979 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849115 COSM6910123 104572814 c.715G>T p.G239C Substitution - Missense het 38 7:55152632-55152632 + - PATHOGENIC .99578 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Gly239Cys ENST00000344576.6:c.715G>T 7:g.55152632G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0000378-T01-IM3 2715158 2573979 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 104570866 c.1793G>C p.G598A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Gly598Ala ENST00000344576.6:c.1793G>C 7:g.55165350G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 C086 2465276 2328109 NS NS NS NS malignant_melanoma NS NS NS y COSV51845994 COSM5530405 104561700 c.1633G>A p.E545K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 23890154 cell-line metastasis ENSP00000345973.2:p.Glu545Lys ENST00000344576.6:c.1633G>A 7:g.55163734G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2014_Lung_sq_14_T 2744885 2603588 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 58 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006758-T01-IM5 2723137 2581958 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51797815 COSM6953729 104580501 c.1867A>C p.N623H Substitution - Missense het 38 7:55165424-55165424 + - PATHOGENIC .99714 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Asn623His ENST00000344576.6:c.1867A>C 7:g.55165424A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S001103 1027689 944665 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 104564298 c.787A>C p.T263P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Thr263Pro ENST00000344576.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 J11 2815385 2671765 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 29263181 surgery fresh/frozen NS 50 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0008601-T01-IM5 2724703 2583524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PDA_074 2367415 2230253 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV51828052 COSM5002066 104591082 c.514T>C p.F172L Substitution - Missense 38 7:55146695-55146695 + - NEUTRAL .04786 Confirmed somatic variant 25855536 NS NS ENSP00000345973.2:p.Phe172Leu ENST00000344576.6:c.514T>C 7:g.55146695T>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-32-1979-01 2120345 1994581 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 104564353 c.809A>G p.Y270C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 329 NS NS 69 ENSP00000345973.2:p.Tyr270Cys ENST00000344576.6:c.809A>G 7:g.55154072A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S001050 1027681 944657 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51835525 COSM21681 104584701 c.136G>A p.D46N Substitution - Missense het 38 7:55142333-55142333 + - PATHOGENIC .94315 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Asp46Asn ENST00000344576.6:c.136G>A 7:g.55142333G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S001050 1027681 944657 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51835541 COSM21682 104584705 c.187G>C p.G63R Substitution - Missense het 38 7:55142384-55142384 + - PATHOGENIC .9897 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Gly63Arg ENST00000344576.6:c.187G>C 7:g.55142384G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 DCG_04 2664382 2524436 central_nervous_system cerebellum NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51838314 COSM6837033 104565941 c.1486G>A p.E496K Substitution - Missense 38 7:55160326-55160326 + - NEUTRAL .08736 Confirmed somatic variant 28852847 surgery fresh/frozen NS 40 ENSP00000345973.2:p.Glu496Lys ENST00000344576.6:c.1486G>A 7:g.55160326G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CSCC-7-T 2292460 2158524 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51852113 COSM4501266 104570275 c.584C>T p.P195L Substitution - Missense het 38 7:55151318-55151318 + - NEUTRAL .31382 Confirmed somatic variant 25303977 surgery fresh/frozen primary 60 ENSP00000345973.2:p.Pro195Leu ENST00000344576.6:c.584C>T 7:g.55151318C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0008179-T01-IM5 2830114 2685929 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 104565296 c.1774G>A p.V592I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000345973.2:p.Val592Ile ENST00000344576.6:c.1774G>A 7:g.55165331G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-12-0619-01 1909590 1798111 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 fresh/frozen - NOS primary 60 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 B105-0 2097254 1975318 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV51776529 COSM1755314 104587793 c.1880G>A p.G627E Substitution - Missense 38 7:55165437-55165437 + - PATHOGENIC .99581 Confirmed somatic variant 24121792 fresh/frozen - NOS NS ENSP00000345973.2:p.Gly627Glu ENST00000344576.6:c.1880G>A 7:g.55165437G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MB-T29 2802988 2659798 breast NS NS NS carcinoma ER-PR-positive_carcinoma NS NS n COSV51836185 COSM4884832 104578863 c.739G>T p.D247Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 26960396 fixed - NOS NS 83 ENSP00000345973.2:p.Asp247Tyr ENST00000344576.6:c.739G>T 7:g.55152656G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-14-1456-01 1338007 1248392 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 23 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0001193-T01-IM3 2716798 2575619 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV51852240 COSM6915314 104564748 c.332T>C p.M111T Substitution - Missense het 38 7:55143396-55143396 + - PATHOGENIC .8651 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Met111Thr ENST00000344576.6:c.332T>C 7:g.55143396T>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0008777-T01-IM5 2724826 2583647 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-92-6393-Tumor-SM-7CKB6 2640208 2500509 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma NS NS y COSV51802220 COSM6458155 104562442 c.940G>A p.D314N Substitution - Missense 38 7:55155880-55155880 + - PATHOGENIC .94623 Confirmed somatic variant 28098136 surgery-fixed primary 65 ENSP00000345973.2:p.Asp314Asn ENST00000344576.6:c.940G>A 7:g.55155880G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-27-1838-01 1338063 1248448 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 104563335 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000345973.2:p.Ala289Asp ENST00000344576.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-1804-01 2120260 1994496 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51855357 COSM3412180 104584932 c.766G>T p.D256Y Substitution - Missense 38 7:55154029-55154029 + - PATHOGENIC .9742 Confirmed somatic variant 329 NS NS 81 ENSP00000345973.2:p.Asp256Tyr ENST00000344576.6:c.766G>T 7:g.55154029G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-14-0790-01 1337989 1248374 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 64 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-VQ-A8PX-01 2339506 2204489 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99285314 COSM8202780 104578202 c.671G>A p.R224H Substitution - Missense 38 7:55152588-55152588 + - PATHOGENIC .91275 Confirmed somatic variant 541 NS primary 51 ENSP00000345973.2:p.Arg224His ENST00000344576.6:c.671G>A 7:g.55152588G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV99293879 COSM8148221 104581754 c.2044G>T p.G682C Substitution - Missense 38 7:55170470-55170470 + - NEUTRAL .00213 Confirmed somatic variant 540 NS NS 37 ENSP00000345973.2:p.Gly682Cys ENST00000344576.6:c.2044G>T 7:g.55170470G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0001124-T01-IM3 2716673 2575494 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51781531 COSM6914964 104572475 c.650A>T p.Q217L Substitution - Missense het 38 7:55152567-55152567 + - PATHOGENIC .9889 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Gln217Leu ENST00000344576.6:c.650A>T 7:g.55152567A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0007562-T01-IM5 2723848 2582669 soft_tissue fibrous_tissue_and_uncertain_origin NS NS malignant_fibrous_histiocytoma-pleomorphic_sarcoma NS NS NS n COSV51779875 COSM6958517 104590158 c.922G>A p.V308I Substitution - Missense het 38 7:55155862-55155862 + - PATHOGENIC .99324 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Val308Ile ENST00000344576.6:c.922G>A 7:g.55155862G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV99293869 COSM8151148 104581729 c.1108C>A p.H370N Substitution - Missense 38 7:55156634-55156634 + - NEUTRAL .19929 Confirmed somatic variant 540 NS NS 37 ENSP00000345973.2:p.His370Asn ENST00000344576.6:c.1108C>A 7:g.55156634C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PD9568a 1649032 1563971 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV51788518 COSM5752712 104575185 c.1786C>G p.P596A Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99615 Confirmed somatic variant 27135926 NS NS ENSP00000345973.2:p.Pro596Ala ENST00000344576.6:c.1786C>G 7:g.55165343C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0008179-T01-IM5 2787021 2644444 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51799199 COSM1251020 104565296 c.1774G>A p.V592I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000345973.2:p.Val592Ile ENST00000344576.6:c.1774G>A 7:g.55165331G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV51830890 COSM3639718 104581718 c.303G>T p.L101F Substitution - Missense 38 7:55143367-55143367 + - PATHOGENIC .93362 Confirmed somatic variant 540 NS NS 37 ENSP00000345973.2:p.Leu101Phe ENST00000344576.6:c.303G>T 7:g.55143367G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2696516 2696516 2555420 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28201779 surgery fresh/frozen NS 68 ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0005929-T01-IM5 2722311 2581132 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GC13 2896794 2751142 placenta NS NS NS choriocarcinoma NS NS NS y COSV105863774 COSM9953649 104566027 c.446G>T p.R149L Substitution - Missense 38 7:55146627-55146627 + - PATHOGENIC .93954 Confirmed somatic variant 33319857 surgery-fixed metastasis 39 ENSP00000345973.2:p.Arg149Leu ENST00000344576.6:c.446G>T 7:g.55146627G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-EE-A2MF-06 2339957 2204940 skin NS NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 104565424 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 540 NS NS 39 ENSP00000345973.2:p.Ser116Phe ENST00000344576.6:c.347C>T 7:g.55143411C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-EE-A2MF-06 2339957 2204940 skin NS NS NS malignant_melanoma NS NS NS y COSV51776559 COSM4892884 104565414 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 540 NS NS 39 ENSP00000345973.2:p.Pro100Ser ENST00000344576.6:c.298C>T 7:g.55143362C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 5-WS012-T14 2869947 2724944 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110458 COSM9657212 104590081 c.1451_1452delinsTT p.S484F Substitution - Missense 38 7:55160291-55160292 + - Confirmed somatic variant 26950094 surgery - NOS NS 82 ENSP00000345973.2:p.Ser484Phe ENST00000344576.6:c.1451_1452delinsTT 7:g.55160291_55160292delinsTT EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P122 2072582 1951937 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 55.2 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T3110 2658365 2518524 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51837186 COSM1090861 104568806 c.442G>A p.V148M Substitution - Missense 38 7:55146623-55146623 + - PATHOGENIC .99004 Confirmed somatic variant 27149842 NS NS 60.33 ENSP00000345973.2:p.Val148Met ENST00000344576.6:c.442G>A 7:g.55146623G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-12-0656 2108024 1985885 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 104563335 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Ala289Asp ENST00000344576.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 600 2131840 2005904 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51777649 COSM3721610 104585085 c.608G>A p.G203E Substitution - Missense 38 7:55151342-55151342 + - PATHOGENIC .98938 Confirmed somatic variant 23619168 fresh/frozen - NOS NS 57 ENSP00000345973.2:p.Gly203Glu ENST00000344576.6:c.608G>A 7:g.55151342G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-FP-A4BE-01 2197995 2066273 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51785413 COSM1176673 104566152 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 541 NS NS 55 ENSP00000345973.2:p.Arg252His ENST00000344576.6:c.755G>A 7:g.55154018G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-76-6661-01 2120394 1994630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51814881 COSM3929116 104573033 c.934G>T p.G312W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 329 NS NS 54 ENSP00000345973.2:p.Gly312Trp ENST00000344576.6:c.934G>T 7:g.55155874G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-76-6661-01 2120394 1994630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 104564009 c.910C>T p.H304Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 NS NS 54 ENSP00000345973.2:p.His304Tyr ENST00000344576.6:c.910C>T 7:g.55155850C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 IGC-04-1136 2662303 2522427 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51809481 COSM6530127 104569948 c.991G>C p.G331R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .97571 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000345973.2:p.Gly331Arg ENST00000344576.6:c.991G>C 7:g.55155931G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-CH-5765-01 1797170 1698917 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51795500 COSM1131544 104583843 c.692G>C p.C231S Substitution - Missense 38 7:55152609-55152609 + - PATHOGENIC .99547 Confirmed somatic variant 435 fresh/frozen - NOS primary 55 ENSP00000345973.2:p.Cys231Ser ENST00000344576.6:c.692G>C 7:g.55152609G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-ER-A42L-06 2456271 2319108 skin NS NS NS malignant_melanoma NS NS NS y COSV99287971 COSM7900658 104579071 c.1781C>T p.T594I Substitution - Missense 38 7:55165338-55165338 + - PATHOGENIC .94394 Confirmed somatic variant 540 NS metastasis 49 ENSP00000345973.2:p.Thr594Ile ENST00000344576.6:c.1781C>T 7:g.55165338C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0000894-T01-IM3 2716206 2575027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51822498 COSM3266565 104580564 c.917C>T p.S306L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Ser306Leu ENST00000344576.6:c.917C>T 7:g.55155857C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-12-0691 2108027 1985888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774829 COSM1451549 104563113 c.767A>G p.D256G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Asp256Gly ENST00000344576.6:c.767A>G 7:g.55154030A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006622-T01-IM5 2786996 2644419 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51845994 COSM5530405 104561700 c.1633G>A p.E545K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000345973.2:p.Glu545Lys ENST00000344576.6:c.1633G>A 7:g.55163734G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194733 1194733 1106628 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 Thyroid-CN-WZ037T 2635098 2495494 thyroid NS NS NS carcinoma NS NS NS y COSV51794993 COSM6399094 104571116 c.5G>A p.R2Q Substitution - Missense 38 7:55019282-55019282 + - NEUTRAL .46409 Confirmed somatic variant 676 NS primary 40 ENSP00000345973.2:p.Arg2Gln ENST00000344576.6:c.5G>A 7:g.55019282G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SDC7 2564876 2426270 salivary_gland NS NS NS carcinoma salivary_duct_carcinoma NS NS y COSV51792147 COSM5988249 104576542 c.1170G>T p.Q390H Substitution - Missense 38 7:55156795-55156795 + - NEUTRAL .3446 Confirmed somatic variant 27103403 surgery fresh/frozen recurrent ENSP00000345973.2:p.Gln390His ENST00000344576.6:c.1170G>T 7:g.55156795G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 Br20P 1312980 1223889 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51815967 COSM39522 104563273 c.655T>G p.C219G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 18772396 surgery - NOS primary 77 ENSP00000345973.2:p.Cys219Gly ENST00000344576.6:c.655T>G 7:g.55152572T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009587-T01-IM5 2725481 2584302 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009587-T01-IM5 2725481 2584302 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 ESCC_BICR_010T 2456865 2319702 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51822386 COSM5436048 104589108 c.1574C>G p.S525C Substitution - Missense 38 7:55161574-55161574 + - PATHOGENIC .96861 Confirmed somatic variant 582 NS primary 70 ENSP00000345973.2:p.Ser525Cys ENST00000344576.6:c.1574C>G 7:g.55161574C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 EX01M 2653306 2513433 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS metastasis 58.5 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CRC104post 2730749 2589518 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV104577027 COSM9413135 104570755 c.1394G>A p.G465E Substitution - Missense 38 7:55160234-55160234 + - NEUTRAL .11765 Confirmed somatic variant 26416732 xenograft metastasis 62 ENSP00000345973.2:p.Gly465Glu ENST00000344576.6:c.1394G>A 7:g.55160234G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0743-01 1337857 1248242 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51853321 COSM3412170 104581382 c.478G>A p.E160K Substitution - Missense 38 7:55146659-55146659 + - PATHOGENIC .9774 Confirmed somatic variant 329 surgery fresh/frozen NS 69 ENSP00000345973.2:p.Glu160Lys ENST00000344576.6:c.478G>A 7:g.55146659G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0743-01 1337857 1248242 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 69 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0002647-T01-IM3 2718893 2577714 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0881-01 1337868 1248253 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-14-1395-01 2120295 1994531 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51827895 COSM3412174 104564425 c.685A>T p.S229C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 329 NS NS 52 ENSP00000345973.2:p.Ser229Cys ENST00000344576.6:c.685A>T 7:g.55152602A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2876622 2876622 2731137 lung NS NS NS carcinoma NS NS NS n COSV51785510 COSM6957413 104561393 c.1102G>A p.D368N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 29506987 circulating tumour NS 51 ENSP00000345973.2:p.Asp368Asn ENST00000344576.6:c.1102G>A 7:g.55156628G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T2946 2658354 2518513 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777851 COSM1205052 104571359 c.494G>A p.R165Q Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .0375 Confirmed somatic variant 27149842 NS NS 78.66 ENSP00000345973.2:p.Arg165Gln ENST00000344576.6:c.494G>A 7:g.55146675G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T3022 2658418 2518577 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51770269 COSM5710629 104580615 c.1015G>A p.G339R Substitution - Missense 38 7:55156541-55156541 + - PATHOGENIC .9949 Confirmed somatic variant 27149842 NS NS 74.83 ENSP00000345973.2:p.Gly339Arg ENST00000344576.6:c.1015G>A 7:g.55156541G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-E1-A7Z2-01 2457427 2320264 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 58 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0011383-T01-IM5 2726979 2585800 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 IGC-01-1037 2662275 2522399 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51838271 COSM6515024 104563532 c.125G>A p.G42D Substitution - Missense 38 7:55142322-55142322 + - PATHOGENIC .98106 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000345973.2:p.Gly42Asp ENST00000344576.6:c.125G>A 7:g.55142322G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-19-1388-01 2178164 2046462 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289486 COSM7485141 104589714 c.1824G>C p.W608C Substitution - Missense 38 7:55165381-55165381 + - PATHOGENIC .98435 Confirmed somatic variant 329 NS NS 58 ENSP00000345973.2:p.Trp608Cys ENST00000344576.6:c.1824G>C 7:g.55165381G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0002294-T02-IM5 2719498 2578319 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51817765 COSM6959438 104566562 c.1802G>A p.G601E Substitution - Missense het 38 7:55165359-55165359 + - PATHOGENIC .9907 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Gly601Glu ENST00000344576.6:c.1802G>A 7:g.55165359G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-97-8172-01 2194801 2063079 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51850921 COSM5982763 104569349 c.1879G>T p.G627W Substitution - Missense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 417 NS NS 75 ENSP00000345973.2:p.Gly627Trp ENST00000344576.6:c.1879G>T 7:g.55165436G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783348 COSM6196859 104571102 c.380C>T p.A127V Substitution - Missense 38 7:55143444-55143444 + - NEUTRAL .27751 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000345973.2:p.Ala127Val ENST00000344576.6:c.380C>T 7:g.55143444C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783354 COSM6196860 104571108 c.415A>G p.N139D Substitution - Missense 38 7:55143479-55143479 + - PATHOGENIC .81387 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000345973.2:p.Asn139Asp ENST00000344576.6:c.415A>G 7:g.55143479A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009830-T01-IM5 2725668 2584489 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 104566152 c.755G>A p.R252H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Arg252His ENST00000344576.6:c.755G>A 7:g.55154018G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006622-T01-IM5 2723002 2581823 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51845994 COSM5530405 104561700 c.1633G>A p.E545K Substitution - Missense het 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Glu545Lys ENST00000344576.6:c.1633G>A 7:g.55163734G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-CV-7103-01 2193635 2061913 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99291703 COSM8371626 104581802 c.112C>G p.L38V Substitution - Missense 38 7:55142309-55142309 + - PATHOGENIC .94561 Confirmed somatic variant 627 NS NS 49 ENSP00000345973.2:p.Leu38Val ENST00000344576.6:c.112C>G 7:g.55142309C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 Pat_41_B 2513797 2376166 NS NS NS NS malignant_melanoma NS NS NS y COSV51772860 COSM5872872 104581853 c.683C>T p.P228L Substitution - Missense 38 7:55152600-55152600 + - PATHOGENIC .99115 Confirmed somatic variant 24265153 surgery-fixed NS 76 ENSP00000345973.2:p.Pro228Leu ENST00000344576.6:c.683C>T 7:g.55152600C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003702-T02-IM5 2720190 2579011 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51831642 COSM1496684 104568540 c.988G>A p.E330K Substitution - Missense het 38 7:55155928-55155928 + - PATHOGENIC .94538 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Glu330Lys ENST00000344576.6:c.988G>A 7:g.55155928G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GBM15 2144555 2013769 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 24285547 surgery fresh/frozen primary 73 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MaPT05 2491636 2354277 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51771223 COSM3929114 104565620 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000345973.2:p.Glu84Val ENST00000344576.6:c.251A>T 7:g.55143315A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV99294040 COSM9120802 104570362 c.379G>A p.A127T Substitution - Missense het 38 7:55143443-55143443 + - NEUTRAL .01752 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000345973.2:p.Ala127Thr ENST00000344576.6:c.379G>A 7:g.55143443G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV104368998 COSM9232920 104570385 c.886C>T p.P296S Substitution - Missense het 38 7:55154149-55154149 + - PATHOGENIC .98876 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000345973.2:p.Pro296Ser ENST00000344576.6:c.886C>T 7:g.55154149C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0001703-T01-IM3 2717826 2576647 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51782832 COSM3881808 104580663 c.739G>A p.D247N Substitution - Missense het 38 7:55152656-55152656 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Asp247Asn ENST00000344576.6:c.739G>A 7:g.55152656G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T2250 2658595 2518754 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51769145 COSM3266559 104581833 c.874G>A p.V292M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 27149842 NS NS 62.08 ENSP00000345973.2:p.Val292Met ENST00000344576.6:c.874G>A 7:g.55154137G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 92177 2807582 2664283 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99293495 COSM9130691 104593381 c.535G>A p.D179N Substitution - Missense 38 7:55146716-55146716 + - PATHOGENIC .99452 Confirmed somatic variant 24807215 surgery fresh/frozen primary 45 ENSP00000345973.2:p.Asp179Asn ENST00000344576.6:c.535G>A 7:g.55146716G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MaPT01s 2491582 2354223 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51775191 COSM1451530 104563232 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000345973.2:p.Gly63Arg ENST00000344576.6:c.187G>A 7:g.55142384G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 I2L-P16-Tumor-Biopsy 2433478 2296359 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51814923 COSM5358036 104564930 c.559T>C p.C187R Substitution - Missense het 38 7:55146740-55146740 + - PATHOGENIC .98691 Confirmed somatic variant 25957691 NS NS 67 ENSP00000345973.2:p.Cys187Arg ENST00000344576.6:c.559T>C 7:g.55146740T>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-14-1456 2108037 1985898 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-5856-01 2120270 1994506 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 58 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-14-1823-01 1338013 1248398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 58 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0125 2107938 1985799 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 LICA-CN-HCC121T 2634168 2494564 liver NS NS NS other neoplasm NS NS y COSV51825459 COSM122789 104567616 c.1423A>G p.I475V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Confirmed somatic variant 660 NS primary 49 ENSP00000345973.2:p.Ile475Val ENST00000344576.6:c.1423A>G 7:g.55160263A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-28-1749-01 2178174 2046472 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 104568632 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 NS NS 73 ENSP00000345973.2:p.Thr363Ile ENST00000344576.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P146 2072599 1951954 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 48 ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0002998-T01-IM3 2719207 2578028 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51805664 COSM6925533 104588652 c.1783T>G p.C595G Substitution - Missense het 38 7:55165340-55165340 + - PATHOGENIC .9957 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Cys595Gly ENST00000344576.6:c.1783T>G 7:g.55165340T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DF-A2KN-01 2457388 2320225 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99289848 COSM9047248 104569178 c.1058C>T p.A353V Substitution - Missense 38 7:55156584-55156584 + - PATHOGENIC .99015 Confirmed somatic variant 419 NS primary ENSP00000345973.2:p.Ala353Val ENST00000344576.6:c.1058C>T 7:g.55156584C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-FG-A70Z-01 2194226 2062504 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 53 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0002490-T01-IM3 2718762 2577583 NS NS NS NS malignant_melanoma NS NS NS n COSV51822525 COSM6922832 104582523 c.1340C>T p.S447F Substitution - Missense het 38 7:55160180-55160180 + - .61329 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Ser447Phe ENST00000344576.6:c.1340C>T 7:g.55160180C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0002490-T01-IM3 2718762 2577583 NS NS NS NS malignant_melanoma NS NS NS n COSV51822498 COSM3266565 104580564 c.917C>T p.S306L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Ser306Leu ENST00000344576.6:c.917C>T 7:g.55155857C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0011389-T01-IM5 2726985 2585806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GBM19-I3 2813467 2669859 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GYWU_828 2771354 2629545 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51794659 COSM6652247 104573964 c.1720C>T p.R574W Substitution - Missense 38 7:55163821-55163821 + - PATHOGENIC .97962 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000345973.2:p.Arg574Trp ENST00000344576.6:c.1720C>T 7:g.55163821C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-FG-A4MW-01 2194412 2062690 central_nervous_system brain NS NS glioma NS NS NS y COSV51814881 COSM3929116 104573033 c.934G>T p.G312W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 545 NS NS 63 ENSP00000345973.2:p.Gly312Trp ENST00000344576.6:c.934G>T 7:g.55155874G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 OSCC-GB_00130111 2121052 1995288 upper_aerodigestive_tract mouth NS NS carcinoma NS NS NS y COSV51815394 COSM3715755 104566674 c.738C>A p.S246R Substitution - Missense 38 7:55152655-55152655 + - NEUTRAL .15461 Confirmed somatic variant 539 NS NS ENSP00000345973.2:p.Ser246Arg ENST00000344576.6:c.738C>A 7:g.55152655C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-02-2466-01 2178184 2046482 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 61 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-BA-4075-01 2193631 2061909 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99292704 COSM8332917 104576345 c.1637C>A p.P546Q Substitution - Missense 38 7:55163738-55163738 + - PATHOGENIC .97378 Confirmed somatic variant 627 NS NS 49 ENSP00000345973.2:p.Pro546Gln ENST00000344576.6:c.1637C>A 7:g.55163738C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-BA-4075-01 2193631 2061909 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99292713 COSM8332789 104576377 c.2026C>T p.P676S Substitution - Missense 38 7:55170452-55170452 + - NEUTRAL .00909 Confirmed somatic variant 627 NS NS 49 ENSP00000345973.2:p.Pro676Ser ENST00000344576.6:c.2026C>T 7:g.55170452C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0011540-T01-IM5 2727112 2585933 small_intestine ileum NS NS carcinoma adenocarcinoma NS NS n COSV51797215 COSM145360 104567668 c.967G>A p.V323I Substitution - Missense het 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Val323Ile ENST00000344576.6:c.967G>A 7:g.55155907G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 B72-S1 2732506 2591266 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 104568632 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 29244145 surgery fresh/frozen primary 76.6 ENSP00000345973.2:p.Thr363Ile ENST00000344576.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SA213 1659983 1574311 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS y COSV51858303 COSM214296 104587965 c.1159C>G p.L387V Substitution - Missense 38 7:55156784-55156784 + - PATHOGENIC .93843 Confirmed somatic variant 22495314 fresh/frozen - NOS primary 49 ENSP00000345973.2:p.Leu387Val ENST00000344576.6:c.1159C>G 7:g.55156784C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-28-5207 2108065 1985926 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 7T 2473854 2336624 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51797600 COSM5575629 104574140 c.391G>A p.G131R Substitution - Missense 38 7:55143455-55143455 + - PATHOGENIC .99768 Confirmed somatic variant 26489445 fixed - NOS NS ENSP00000345973.2:p.Gly131Arg ENST00000344576.6:c.391G>A 7:g.55143455G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SJALL040461-D 2824035 2679863 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV104576718 COSM9280424 104568673 c.1592G>A p.R531Q Substitution - Missense 38 7:55161592-55161592 + - PATHOGENIC .99386 Confirmed somatic variant 31697823 blood-bone marrow NS 11.64 ENSP00000345973.2:p.Arg531Gln ENST00000344576.6:c.1592G>A 7:g.55161592G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0008346-T01-IM5 2724474 2583295 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51838649 COSM6962468 104583035 c.412A>G p.R138G Substitution - Missense het 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg138Gly ENST00000344576.6:c.412A>G 7:g.55143476A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 EXTERN_MELA_20140505_038 2839416 2695182 skin ear NS NS malignant_melanoma NS NS NS y COSV104577055 COSM9446911 104574685 c.887C>T p.P296L Substitution - Missense 38 7:55154150-55154150 + - PATHOGENIC .98876 Confirmed somatic variant 28467829 surgery fresh/frozen recurrent ENSP00000345973.2:p.Pro296Leu ENST00000344576.6:c.887C>T 7:g.55154150C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-WE-AAA4-06 2339475 2204458 skin NS NS NS malignant_melanoma NS NS NS y COSV99286479 COSM8046349 104571083 c.1390T>C p.S464P Substitution - Missense 38 7:55160230-55160230 + - PATHOGENIC .73545 Confirmed somatic variant 540 NS NS 56 ENSP00000345973.2:p.Ser464Pro ENST00000344576.6:c.1390T>C 7:g.55160230T>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MaPT10 2491641 2354282 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-13-0912-01 1474988 1398687 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51781835 COSM174732 104564456 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 21720365 331 NS primary 58 ENSP00000345973.2:p.Glu114Lys ENST00000344576.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-13-0912-01 1474988 1398687 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51781835 COSM174732 104564456 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 331 NS primary 58 ENSP00000345973.2:p.Glu114Lys ENST00000344576.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 618 1630888 1547758 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51797215 COSM145360 104567668 c.967G>A p.V323I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 22158541 blood-bone marrow NS ENSP00000345973.2:p.Val323Ile ENST00000344576.6:c.967G>A 7:g.55155907G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0010340-T01-IM5 2726107 2584928 NS NS NS NS malignant_melanoma NS NS NS n COSV51799199 COSM1251020 104565296 c.1774G>A p.V592I Substitution - Missense het 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Val592Ile ENST00000344576.6:c.1774G>A 7:g.55165331G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 5-WS012-T2 2869948 2724945 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110279 COSM9809368 104595442 c.299C>T p.P100L Substitution - Missense 38 7:55143363-55143363 + - PATHOGENIC .96024 Confirmed somatic variant 26950094 surgery - NOS NS 82 ENSP00000345973.2:p.Pro100Leu ENST00000344576.6:c.299C>T 7:g.55143363C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009873-T01-IM5 2725712 2584533 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-HT-8107-01 2194409 2062687 central_nervous_system brain NS NS glioma NS NS NS y COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 545 NS NS 62 ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S001076 1027683 944659 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DU-A7TD-01 2339610 2204593 central_nervous_system brain NS NS glioma NS NS NS y COSV99294781 COSM8258176 104588501 c.827A>T p.Q276L Substitution - Missense 38 7:55154090-55154090 + - PATHOGENIC .97144 Confirmed somatic variant 545 NS primary 52 ENSP00000345973.2:p.Gln276Leu ENST00000344576.6:c.827A>T 7:g.55154090A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0007084-T02-IM5 2723457 2582278 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51797839 COSM6958991 104581652 c.37G>A p.A13T Substitution - Missense het 38 7:55019314-55019314 + - NEUTRAL .01885 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Ala13Thr ENST00000344576.6:c.37G>A 7:g.55019314G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0749 2107988 1985849 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003783-T01-IM5 2720274 2579095 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 HUB-02-B2-027 2607091 2466805 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51820896 COSM6051251 104571850 c.1894A>T p.S632C Substitution - Missense 38 7:55170320-55170320 + - NEUTRAL .01705 Confirmed somatic variant 670 organoid culture NS ENSP00000345973.2:p.Ser632Cys ENST00000344576.6:c.1894A>T 7:g.55170320A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 OSCC-GB_00550111 2340760 2205743 upper_aerodigestive_tract mouth NS NS carcinoma NS NS NS y COSV51836185 COSM4884832 104578863 c.739G>T p.D247Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 539 NS primary 58 ENSP00000345973.2:p.Asp247Tyr ENST00000344576.6:c.739G>T 7:g.55152656G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2665864 2665864 2525572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792237 COSM6842523 104567641 c.829_830delinsGA p.M277E Substitution - Missense het 38 7:55154092-55154093 + - Confirmed somatic variant 28979142 surgery - NOS NS 70 ENSP00000345973.2:p.Met277Glu ENST00000344576.6:c.829_830delinsGA 7:g.55154092_55154093delinsGA EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-CV-6961-01 2193755 2062033 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51839851 COSM7340115 104576384 c.1118C>A p.P373Q Substitution - Missense 38 7:55156644-55156644 + - PATHOGENIC .76649 Confirmed somatic variant 627 NS NS 61 ENSP00000345973.2:p.Pro373Gln ENST00000344576.6:c.1118C>A 7:g.55156644C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S001094 1027685 944661 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0008215-T01-IM5 2830122 2685937 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51834499 COSM6845063 104562494 c.964G>A p.G322S Substitution - Missense 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 30205045 surgery-fixed primary 58 ENSP00000345973.2:p.Gly322Ser ENST00000344576.6:c.964G>A 7:g.55155904G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-76-6656-01 2120392 1994628 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51857475 COSM3412176 104584898 c.719G>A p.C240Y Substitution - Missense 38 7:55152636-55152636 + - PATHOGENIC .99504 Confirmed somatic variant 329 NS NS 66 ENSP00000345973.2:p.Cys240Tyr ENST00000344576.6:c.719G>A 7:g.55152636G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801732 COSM3923812 104588031 c.1091C>T p.S364F Substitution - Missense 38 7:55156617-55156617 + - NEUTRAL .433 Confirmed somatic variant 540 NS NS 68 ENSP00000345973.2:p.Ser364Phe ENST00000344576.6:c.1091C>T 7:g.55156617C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-E5-A2PC-01 1898110 1786794 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51779680 COSM1313184 104577433 c.1151C>G p.T384S Substitution - Missense 38 7:55156776-55156776 + - PATHOGENIC .98418 Confirmed somatic variant 413 fresh/frozen - NOS primary 61 ENSP00000345973.2:p.Thr384Ser ENST00000344576.6:c.1151C>G 7:g.55156776C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 EXTERN_MELA_20140924_067 2839387 2695153 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV104577161 COSM9392986 104587340 c.1444G>A p.G482R Substitution - Missense 38 7:55160284-55160284 + - PATHOGENIC .93959 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000345973.2:p.Gly482Arg ENST00000344576.6:c.1444G>A 7:g.55160284G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1690853 1690853 1599120 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 104568799 c.1476C>A p.S492R Substitution - Missense 38 7:55160316-55160316 + - NEUTRAL .35843 Confirmed somatic variant 22270724 surgery - NOS recurrent 52 ENSP00000345973.2:p.Ser492Arg ENST00000344576.6:c.1476C>A 7:g.55160316C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T578 2658233 2518392 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51788796 COSM4680390 104574158 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 27149842 NS NS 61.08 ENSP00000345973.2:p.Arg98Gln ENST00000344576.6:c.293G>A 7:g.55143357G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 DUMC-05 2748702 2607405 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 29802247 surgery fresh/frozen NS 51 ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2842026 2842026 2697575 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 104568374 c.1474A>C p.S492R Substitution - Missense 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000345973.2:p.Ser492Arg ENST00000344576.6:c.1474A>C 7:g.55160314A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 Br02X 1312964 1223873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 xenograft primary 39 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0007381-T01-IM5 2723717 2582538 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51814979 COSM6957934 104582097 c.1335A>G p.I445M Substitution - Missense het 38 7:55160175-55160175 + - NEUTRAL .42702 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Ile445Met ENST00000344576.6:c.1335A>G 7:g.55160175A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-81-5911-01 2120399 1994635 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 33 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 Br112X 1313001 1223910 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 18772396 xenograft primary 48 ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0004379-T01-IM5 2720790 2579611 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51857819 COSM6935325 104570306 c.1397A>C p.N466T Substitution - Missense het 38 7:55160237-55160237 + - PATHOGENIC .99346 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Asn466Thr ENST00000344576.6:c.1397A>C 7:g.55160237A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DI-A1BU-01 2198300 2066578 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99287849 COSM8863291 104575271 c.1666A>G p.I556V Substitution - Missense 38 7:55163767-55163767 + - NEUTRAL .09266 Confirmed somatic variant 419 NS NS 55 ENSP00000345973.2:p.Ile556Val ENST00000344576.6:c.1666A>G 7:g.55163767A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-KK-A59Y-01 2340238 2205221 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51814881 COSM3929116 104573033 c.934G>T p.G312W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 435 NS primary 56 ENSP00000345973.2:p.Gly312Trp ENST00000344576.6:c.934G>T 7:g.55155874G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-EY-A2OM-01 2198301 2066579 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99285698 COSM9064376 104568871 c.833A>G p.D278G Substitution - Missense 38 7:55154096-55154096 + - PATHOGENIC .95224 Confirmed somatic variant 419 NS NS 55 ENSP00000345973.2:p.Asp278Gly ENST00000344576.6:c.833A>G 7:g.55154096A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 16668 1423695 1333723 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790297 COSM48317 104589365 c.406C>A p.P136T Substitution - Missense het 38 7:55143470-55143470 + - PATHOGENIC .9933 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000345973.2:p.Pro136Thr ENST00000344576.6:c.406C>A 7:g.55143470C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 R056-I1 2813481 2669873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289246 COSM8268187 104564057 c.788C>T p.T263I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 28263318 surgery fresh/frozen NS 42 ENSP00000345973.2:p.Thr263Ile ENST00000344576.6:c.788C>T 7:g.55154051C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-14-1034-02 2120293 1994529 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51775191 COSM1451530 104563232 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 329 NS NS 60 ENSP00000345973.2:p.Gly63Arg ENST00000344576.6:c.187G>A 7:g.55142384G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T1849 2658271 2518430 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51794659 COSM6652247 104573964 c.1720C>T p.R574W Substitution - Missense 38 7:55163821-55163821 + - PATHOGENIC .97962 Confirmed somatic variant 27149842 NS NS 79.25 ENSP00000345973.2:p.Arg574Trp ENST00000344576.6:c.1720C>T 7:g.55163821C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0001278-T01-IM3 2716974 2575795 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51844468 COSM6916179 104573189 c.308A>T p.N103I Substitution - Missense het 38 7:55143372-55143372 + - PATHOGENIC .97828 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Asn103Ile ENST00000344576.6:c.308A>T 7:g.55143372A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-27-2528-01 1338071 1248456 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 surgery fresh/frozen NS 62 ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T578 2296255 2161858 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51788796 COSM4680390 104574158 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 25344691 NS NS 61.08 ENSP00000345973.2:p.Arg98Gln ENST00000344576.6:c.293G>A 7:g.55143357G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006713-T01-IM5 2723092 2581913 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51784387 COSM6953025 104592043 c.70G>T p.A24S Substitution - Missense het 38 7:55019347-55019347 + - NEUTRAL .37583 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Ala24Ser ENST00000344576.6:c.70G>T 7:g.55019347G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787547 COSM6191455 104563002 c.1126T>C p.F376L Substitution - Missense 38 7:55156652-55156652 + - PATHOGENIC .98052 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000345973.2:p.Phe376Leu ENST00000344576.6:c.1126T>C 7:g.55156652T>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-BB-A5HY-01 2385721 2248553 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99289265 COSM8389919 104592451 c.1255G>C p.A419P Substitution - Missense 38 7:55157710-55157710 + - PATHOGENIC .9183 Confirmed somatic variant 627 NS primary 64 ENSP00000345973.2:p.Ala419Pro ENST00000344576.6:c.1255G>C 7:g.55157710G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 3101B7_035_T 2390296 2253128 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51811266 COSM5041204 104578302 c.385A>G p.K129E Substitution - Missense 38 7:55143449-55143449 + - PATHOGENIC .9498 Confirmed somatic variant 25159915 NS NS ENSP00000345973.2:p.Lys129Glu ENST00000344576.6:c.385A>G 7:g.55143449A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 XHDG25 2306032 2171303 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV51811244 COSM4767521 104564284 c.607G>A p.G203R Substitution - Missense 38 7:55151341-55151341 + - PATHOGENIC .99471 Confirmed somatic variant 24997986 NS NS ENSP00000345973.2:p.Gly203Arg ENST00000344576.6:c.607G>A 7:g.55151341G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801711 COSM3923810 104588023 c.907G>A p.D303N Substitution - Missense 38 7:55155847-55155847 + - PATHOGENIC .99324 Confirmed somatic variant 540 NS NS 68 ENSP00000345973.2:p.Asp303Asn ENST00000344576.6:c.907G>A 7:g.55155847G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PD7043a 1504254 1427132 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia NS n COSV51852469 COSM4384119 104564810 c.1417A>G p.N473D Substitution - Missense 38 7:55160257-55160257 + - NEUTRAL .3314 Confirmed somatic variant 24030381 NS NS ENSP00000345973.2:p.Asn473Asp ENST00000344576.6:c.1417A>G 7:g.55160257A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51781835 COSM174732 104564456 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Glu114Lys ENST00000344576.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-28-5213-01 2120336 1994572 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 72 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 M702PT 2671818 2531377 pleura NS NS NS mesothelioma epithelial NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26928227 surgery fresh/frozen primary 30 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0876 2107991 1985852 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51865283 COSM6970485 104593765 c.188G>A p.G63E Substitution - Missense het 38 7:55142385-55142385 + - PATHOGENIC .95671 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Gly63Glu ENST00000344576.6:c.188G>A 7:g.55142385G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 238 2131812 2005876 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 23619168 fresh/frozen - NOS NS 50 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SK01600_P 1951898 1838690 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51835132 COSM1600351 104585487 c.977G>C p.C326S Substitution - Missense het 38 7:55155917-55155917 + - PATHOGENIC .99486 Confirmed somatic variant 23441165 surgery - NOS primary 57 ENSP00000345973.2:p.Cys326Ser ENST00000344576.6:c.977G>C 7:g.55155917G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0750 2107989 1985850 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51807036 COSM2151966 104569075 c.1787C>G p.P596R Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99615 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Pro596Arg ENST00000344576.6:c.1787C>G 7:g.55165344C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-28-1752-01 2178270 2046568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 42 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-02-2485-01 1337809 1248194 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 104563335 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 NS NS 53 ENSP00000345973.2:p.Ala289Asp ENST00000344576.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0008179-T01-IM5 2724346 2583167 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 104565296 c.1774G>A p.V592I Substitution - Missense het 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Val592Ile ENST00000344576.6:c.1774G>A 7:g.55165331G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0007319-T01-IM5 2723658 2582479 penis NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51785510 COSM6957413 104561393 c.1102G>A p.D368N Substitution - Missense het 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Asp368Asn ENST00000344576.6:c.1102G>A 7:g.55156628G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-43-A56U-01 2195058 2063336 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99290842 COSM8713904 104591751 c.575C>G p.P192R Substitution - Missense 38 7:55151309-55151309 + - PATHOGENIC .9684 Confirmed somatic variant 418 NS NS 76 ENSP00000345973.2:p.Pro192Arg ENST00000344576.6:c.575C>G 7:g.55151309C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-BR-6452-01 2197940 2066218 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51804028 COSM3881820 104568073 c.1507G>T p.G503C Substitution - Missense 38 7:55161507-55161507 + - NEUTRAL .38516 Confirmed somatic variant 541 NS NS 78 ENSP00000345973.2:p.Gly503Cys ENST00000344576.6:c.1507G>T 7:g.55161507G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 Br229T 1313048 1223957 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51848573 COSM39565 104580139 c.931T>A p.C311S Substitution - Missense het 38 7:55155871-55155871 + - PATHOGENIC .98855 Confirmed somatic variant 18772396 surgery - NOS primary 28 ENSP00000345973.2:p.Cys311Ser ENST00000344576.6:c.931T>A 7:g.55155871T>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-D3-A8GC-06 2262878 2129862 skin NS NS NS malignant_melanoma NS NS NS y COSV51822525 COSM6922832 104582523 c.1340C>T p.S447F Substitution - Missense 38 7:55160180-55160180 + - .61329 Confirmed somatic variant 540 NS NS 48 ENSP00000345973.2:p.Ser447Phe ENST00000344576.6:c.1340C>T 7:g.55160180C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 Br213T 1313043 1223952 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 surgery - NOS primary 71 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 DUMC-05 2748702 2607405 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 29802247 surgery fresh/frozen NS 51 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV51778830 COSM1698691 104564342 c.1198G>A p.E400K Substitution - Missense 38 7:55156823-55156823 + - PATHOGENIC .99571 Confirmed somatic variant 540 NS NS 90 ENSP00000345973.2:p.Glu400Lys ENST00000344576.6:c.1198G>A 7:g.55156823G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T1849 2658271 2518430 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51794620 COSM6652251 104587896 c.46G>A p.A16T Substitution - Missense 38 7:55019323-55019323 + - NEUTRAL .21777 Confirmed somatic variant 27149842 NS NS 79.25 ENSP00000345973.2:p.Ala16Thr ENST00000344576.6:c.46G>A 7:g.55019323G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194732 1194732 1106627 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-32-1970-01 1338089 1248474 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CHG-100T 2634282 2494678 liver NS NS NS other neoplasm NS NS y COSV51842976 COSM6287773 104561676 c.1352G>A p.R451H Substitution - Missense 38 7:55160192-55160192 + - PATHOGENIC .98594 Confirmed somatic variant 660 NS primary 65 ENSP00000345973.2:p.Arg451His ENST00000344576.6:c.1352G>A 7:g.55160192G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0008179-T02-IM5 2830115 2685930 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 104565296 c.1774G>A p.V592I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000345973.2:p.Val592Ile ENST00000344576.6:c.1774G>A 7:g.55165331G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0011226-T01-IM5 2726843 2585664 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51842174 COSM6979569 104566873 c.1610A>T p.D537V Substitution - Missense het 38 7:55161610-55161610 + - PATHOGENIC .78722 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Asp537Val ENST00000344576.6:c.1610A>T 7:g.55161610A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 EXTERN_MELA_20140924_001 2839320 2695086 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51781835 COSM174732 104564456 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28467829 cell-line metastasis ENSP00000345973.2:p.Glu114Lys ENST00000344576.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51865345 COSM6970489 104593791 c.1177G>A p.D393N Substitution - Missense het 38 7:55156802-55156802 + - PATHOGENIC .91392 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Asp393Asn ENST00000344576.6:c.1177G>A 7:g.55156802G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0007037-T01-IM5 2830039 2685854 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843415 COSM6955777 104581241 c.1239C>A p.N413K Substitution - Missense 38 7:55157694-55157694 + - PATHOGENIC .97853 Confirmed somatic variant 30205045 surgery-fixed metastasis 57 ENSP00000345973.2:p.Asn413Lys ENST00000344576.6:c.1239C>A 7:g.55157694C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 R056-I1 2813481 2669873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 42 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2014_Lung_sq_82_T 2744953 2603656 lung NS NS NS carcinoma NS NS NS y COSV51818649 COSM7238502 104589926 c.1362G>T p.K454N Substitution - Missense 38 7:55160202-55160202 + - PATHOGENIC .92978 Confirmed somatic variant 583 NS primary 62 ENSP00000345973.2:p.Lys454Asn ENST00000344576.6:c.1362G>T 7:g.55160202G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-14-0866-01 2178121 2046419 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99295486 COSM7482458 104574817 c.1139C>T p.S380F Substitution - Missense 38 7:55156764-55156764 + - NEUTRAL .25937 Confirmed somatic variant 329 NS NS 55 ENSP00000345973.2:p.Ser380Phe ENST00000344576.6:c.1139C>T 7:g.55156764C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MELA_34952 2760718 2619251 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV51785510 COSM6957413 104561393 c.1102G>A p.D368N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 30178487 surgery fresh/frozen metastasis 25 ENSP00000345973.2:p.Asp368Asn ENST00000344576.6:c.1102G>A 7:g.55156628G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 104564298 c.787A>C p.T263P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Thr263Pro ENST00000344576.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 HUB-02-B2-042 2607096 2466810 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51802097 COSM6047686 104589072 c.299C>A p.P100H Substitution - Missense 38 7:55143363-55143363 + - PATHOGENIC .9585 Confirmed somatic variant 670 organoid culture NS ENSP00000345973.2:p.Pro100His ENST00000344576.6:c.299C>A 7:g.55143363C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0007897-T01-IM5 2724108 2582929 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787557 COSM6191456 104563008 c.1337C>T p.T446I Substitution - Missense 38 7:55160177-55160177 + - NEUTRAL .13103 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000345973.2:p.Thr446Ile ENST00000344576.6:c.1337C>T 7:g.55160177C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-25-2404-01 1474989 1398688 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV99292585 COSM7509017 104568922 c.1381G>A p.V461M Substitution - Missense 38 7:55160221-55160221 + - PATHOGENIC .98193 Confirmed somatic variant 21720365 331 NS primary 38 ENSP00000345973.2:p.Val461Met ENST00000344576.6:c.1381G>A 7:g.55160221G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-25-2404-01 1474989 1398688 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV99292585 COSM7509017 104568922 c.1381G>A p.V461M Substitution - Missense 38 7:55160221-55160221 + - PATHOGENIC .98193 Confirmed somatic variant 331 NS primary 38 ENSP00000345973.2:p.Val461Met ENST00000344576.6:c.1381G>A 7:g.55160221G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0007037-T01-IM5 2723412 2582233 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843415 COSM6955777 104581241 c.1239C>A p.N413K Substitution - Missense het 38 7:55157694-55157694 + - PATHOGENIC .97853 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Asn413Lys ENST00000344576.6:c.1239C>A 7:g.55157694C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 W016-S2 2732511 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 10677523 2751151 2609847 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV105822270 COSM9522396 104572941 c.1784G>C p.C595S Substitution - Missense 38 7:55165341-55165341 + - Confirmed somatic variant 29748005 circulating tumour NS ENSP00000345973.2:p.Cys595Ser ENST00000344576.6:c.1784G>C 7:g.55165341G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 10677523 2751151 2609847 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV105822269 COSM9522392 104572922 c.1006G>C p.V336L Substitution - Missense 38 7:55155946-55155946 + - Confirmed somatic variant 29748005 circulating tumour NS ENSP00000345973.2:p.Val336Leu ENST00000344576.6:c.1006G>C 7:g.55155946G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T_CCA_SG_13 2688086 2547068 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV51803429 COSM7002279 104567135 c.1280G>A p.R427H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Confirmed somatic variant 653 NS primary 60 ENSP00000345973.2:p.Arg427His ENST00000344576.6:c.1280G>A 7:g.55157735G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DA-A3F3-06 2121581 1995817 skin NS NS NS malignant_melanoma NS NS NS y COSV51816429 COSM1698693 104569289 c.1810A>G p.N604D Substitution - Missense 38 7:55165367-55165367 + - NEUTRAL .4812 Confirmed somatic variant 540 NS NS 52 ENSP00000345973.2:p.Asn604Asp ENST00000344576.6:c.1810A>G 7:g.55165367A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003679-T01-IM5 2720169 2578990 stomach gastroesophageal_junction NS NS carcinoma adenocarcinoma NS NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PD6511a 1491955 1415113 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_unilineage_dysplasia refractory_anaemia n COSV51792673 COSM4384113 104585616 c.523A>G p.N175D Substitution - Missense 38 7:55146704-55146704 + - PATHOGENIC .986 Confirmed somatic variant 24030381 NS NS ENSP00000345973.2:p.Asn175Asp ENST00000344576.6:c.523A>G 7:g.55146704A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0002999-T01-IM3 2783044 2640827 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 104566152 c.755G>A p.R252H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28825054 surgery-fixed primary 57 ENSP00000345973.2:p.Arg252His ENST00000344576.6:c.755G>A 7:g.55154018G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 EXTERN_MELA_20140924_131 2839485 2695251 skin scalp NS NS malignant_melanoma NS NS NS y COSV104576577 COSM9396332 104569429 c.1391C>T p.S464L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000345973.2:p.Ser464Leu ENST00000344576.6:c.1391C>T 7:g.55160231C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CRC65 2730847 2589616 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV105863705 COSM10062224 104561490 c.193T>G p.L65V Substitution - Missense 38 7:55142390-55142390 + - PATHOGENIC .83273 Confirmed somatic variant 26416732 xenograft metastasis 45 ENSP00000345973.2:p.Leu65Val ENST00000344576.6:c.193T>G 7:g.55142390T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-14-1455-01 2178074 2046372 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 104568632 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 NS NS 61 ENSP00000345973.2:p.Thr363Ile ENST00000344576.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2492703 2492703 2355318 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 104574373 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000345973.2:p.His47Tyr ENST00000344576.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-BR-8680-01 2197966 2066244 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51785413 COSM1176673 104566152 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 541 NS NS 45 ENSP00000345973.2:p.Arg252His ENST00000344576.6:c.755G>A 7:g.55154018G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0008215-T01-IM5 2724369 2583190 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51834499 COSM6845063 104562494 c.964G>A p.G322S Substitution - Missense het 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Gly322Ser ENST00000344576.6:c.964G>A 7:g.55155904G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 B105-0-Tumor 2185749 2054046 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51776529 COSM1755314 104587793 c.1880G>A p.G627E Substitution - Missense 38 7:55165437-55165437 + - PATHOGENIC .99581 Confirmed somatic variant 581 NS NS ENSP00000345973.2:p.Gly627Glu ENST00000344576.6:c.1880G>A 7:g.55165437G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DU-7006-01 2194244 2062522 central_nervous_system brain NS NS glioma NS NS NS y COSV51800797 COSM3412178 104567250 c.755G>C p.R252P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 545 NS NS 60 ENSP00000345973.2:p.Arg252Pro ENST00000344576.6:c.755G>C 7:g.55154018G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003108-T01-IM5 2719604 2578425 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51866279 COSM6926300 104564036 c.665G>A p.R222H Substitution - Missense het 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000345973.2:p.Arg222His ENST00000344576.6:c.665G>A 7:g.55152582G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-14-1829-01 1338016 1248401 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 104568632 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 surgery fresh/frozen NS 57 ENSP00000345973.2:p.Thr363Ile ENST00000344576.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006612-T01-IM5 2722991 2581812 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51843352 COSM6950555 104581218 c.530C>T p.S177L Substitution - Missense het 38 7:55146711-55146711 + - NEUTRAL .28714 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ser177Leu ENST00000344576.6:c.530C>T 7:g.55146711C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-D7-6521-01 2198059 2066337 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51778897 COSM3881800 104589438 c.253G>A p.V85M Substitution - Missense 38 7:55143317-55143317 + - PATHOGENIC .99051 Confirmed somatic variant 541 NS NS 65 ENSP00000345973.2:p.Val85Met ENST00000344576.6:c.253G>A 7:g.55143317G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 Br215T 1313044 1223953 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51785554 COSM21688 104562387 c.971G>T p.R324L Substitution - Missense het 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 18772396 surgery - NOS primary 50 ENSP00000345973.2:p.Arg324Leu ENST00000344576.6:c.971G>T 7:g.55155911G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 019T 2067099 1946896 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51840438 COSM1727959 104571572 c.374A>G p.Y125C Substitution - Missense 38 7:55143438-55143438 + - PATHOGENIC .99088 Confirmed somatic variant 23788652 surgery - NOS primary ENSP00000345973.2:p.Tyr125Cys ENST00000344576.6:c.374A>G 7:g.55143438A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SC-her2-051 2313868 2179064 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51850832 COSM4943273 104594174 c.840C>A p.N280K Substitution - Missense 38 7:55154103-55154103 + - PATHOGENIC .93631 Confirmed somatic variant 24185512 surgery fresh/frozen metastasis ENSP00000345973.2:p.Asn280Lys ENST00000344576.6:c.840C>A 7:g.55154103C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006124-T01-IM5 2722503 2581324 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51842040 COSM6948138 104582992 c.1077C>G p.F359L Substitution - Missense het 38 7:55156603-55156603 + - PATHOGENIC .96894 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Phe359Leu ENST00000344576.6:c.1077C>G 7:g.55156603C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 7C 2549418 2410873 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51792433 COSM6966446 104579842 c.1762G>A p.G588S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 646 NS primary 66 ENSP00000345973.2:p.Gly588Ser ENST00000344576.6:c.1762G>A 7:g.55165319G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-FG-A4MU-01 2194395 2062673 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 58 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0876 2107991 1985852 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-2557-01 1337877 1248262 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 76 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-32-1982-01 1338091 1248476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 76 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 LICA-CN-HCC055T 2634102 2494498 liver NS NS NS other neoplasm NS NS y COSV51829036 COSM5823994 104574486 c.1001G>C p.R334P Substitution - Missense 38 7:55155941-55155941 + - PATHOGENIC .84442 Confirmed somatic variant 660 NS primary 65 ENSP00000345973.2:p.Arg334Pro ENST00000344576.6:c.1001G>C 7:g.55155941G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 ILMN13 2816773 2673124 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51797307 COSM1090871 104572879 c.1310C>A p.S437Y Substitution - Missense 38 7:55160150-55160150 + - PATHOGENIC .98943 Confirmed somatic variant 29937994 surgery fresh/frozen NS 54 ENSP00000345973.2:p.Ser437Tyr ENST00000344576.6:c.1310C>A 7:g.55160150C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-28-1752-01 2178270 2046568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 42 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 LC_C30 1863711 1754602 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 22975805 surgery fresh/frozen primary 38 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-S9-A7IX-01 2263383 2130367 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 57 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2014_Lung_sq_15_T 2744886 2603589 lung NS NS NS carcinoma NS NS NS y COSV51805367 COSM3950642 104578352 c.1039G>A p.D347N Substitution - Missense 38 7:55156565-55156565 + - PATHOGENIC .82248 Confirmed somatic variant 583 NS primary 72 ENSP00000345973.2:p.Asp347Asn ENST00000344576.6:c.1039G>A 7:g.55156565G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787534 COSM6191454 104562999 c.1075T>C p.F359L Substitution - Missense 38 7:55156601-55156601 + - PATHOGENIC .99231 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000345973.2:p.Phe359Leu ENST00000344576.6:c.1075T>C 7:g.55156601T>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PCA0136 2580109 2441446 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51788967 COSM6005513 104585128 c.446G>A p.R149Q Substitution - Missense 38 7:55146627-55146627 + - PATHOGENIC .75281 Confirmed somatic variant 20579941 surgery fresh/frozen primary 54 ENSP00000345973.2:p.Arg149Gln ENST00000344576.6:c.446G>A 7:g.55146627G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-BH-A18U-01 1899961 1788645 breast NS NS NS carcinoma NS NS NS y COSV99294745 COSM7670588 104581910 c.769G>A p.E257K Substitution - Missense 38 7:55154032-55154032 + - PATHOGENIC .97243 Confirmed somatic variant 414 fresh/frozen - NOS primary 72 ENSP00000345973.2:p.Glu257Lys ENST00000344576.6:c.769G>A 7:g.55154032G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006441-T01-IM5 2722817 2581638 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51775191 COSM1451530 104563232 c.187G>A p.G63R Substitution - Missense het 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Gly63Arg ENST00000344576.6:c.187G>A 7:g.55142384G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0155-01 1337821 1248206 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 104564009 c.910C>T p.H304Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 surgery fresh/frozen NS 61 ENSP00000345973.2:p.His304Tyr ENST00000344576.6:c.910C>T 7:g.55155850C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MSU4-c 2809981 2666643 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV99291971 COSM9172239 104577664 c.1820T>C p.V607A Substitution - Missense 38 7:55165377-55165377 + - PATHOGENIC .99812 Confirmed somatic variant 26336987 surgery fresh/frozen primary 76 ENSP00000345973.2:p.Val607Ala ENST00000344576.6:c.1820T>C 7:g.55165377T>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0174-01 1910190 1798481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 fresh/frozen - NOS primary 54 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-28-5207-01 2120332 1994568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 71 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0142-01 2120247 1994483 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 81 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CGCRC167 2434467 2297344 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV105863924 COSM10049276 104572744 c.1040A>T p.D347V Substitution - Missense 38 7:55156566-55156566 + - PATHOGENIC .89104 Confirmed somatic variant 26416732 surgery - NOS primary 81 ENSP00000345973.2:p.Asp347Val ENST00000344576.6:c.1040A>T 7:g.55156566A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DK-AA75-01 2385754 2248586 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51771467 COSM7104388 104570042 c.1077C>A p.F359L Substitution - Missense 38 7:55156603-55156603 + - PATHOGENIC .96682 Confirmed somatic variant 413 NS primary 82 ENSP00000345973.2:p.Phe359Leu ENST00000344576.6:c.1077C>A 7:g.55156603C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194726 1194726 1106621 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0007504-T01-IM5 2723789 2582610 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-14-1455 2108036 1985897 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 104568632 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Thr363Ile ENST00000344576.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0174-01 1910190 1798481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51773690 COSM3412198 104591262 c.1841G>A p.G614D Substitution - Missense 38 7:55165398-55165398 + - NEUTRAL .00947 Confirmed somatic variant 329 fresh/frozen - NOS primary 54 ENSP00000345973.2:p.Gly614Asp ENST00000344576.6:c.1841G>A 7:g.55165398G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SJHYPO052-R 2590153 2451283 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 104565402 c.1279C>T p.R427C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 23334668 blood-bone marrow recurrent 16.3 ENSP00000345973.2:p.Arg427Cys ENST00000344576.6:c.1279C>T 7:g.55157734C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-HT-8110-01 2194393 2062671 central_nervous_system brain NS NS glioma NS NS NS y COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 545 NS NS 57 ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0010610-T01-IM5 2726309 2585130 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51839766 COSM6975560 104565594 c.1864C>G p.P622A Substitution - Missense het 38 7:55165421-55165421 + - NEUTRAL .24318 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Pro622Ala ENST00000344576.6:c.1864C>G 7:g.55165421C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0008450-T01-IM5 2724567 2583388 skin NS NS NS malignant_melanoma NS NS NS n COSV51822498 COSM3266565 104580564 c.917C>T p.S306L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ser306Leu ENST00000344576.6:c.917C>T 7:g.55155857C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2697837 2697837 2556741 breast NS NS NS carcinoma NS NS NS n COSV51811430 COSM6906106 104592037 c.1265A>G p.N422S Substitution - Missense 38 7:55157720-55157720 + - PATHOGENIC .99784 Confirmed somatic variant 29349598 NS NS ENSP00000345973.2:p.Asn422Ser ENST00000344576.6:c.1265A>G 7:g.55157720A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PD6313a 1483843 1407469 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_ringed_sideroblasts NS n COSV51819755 COSM4384123 104593996 c.1601A>C p.E534A Substitution - Missense 38 7:55161601-55161601 + - PATHOGENIC .82008 Confirmed somatic variant 24030381 NS NS ENSP00000345973.2:p.Glu534Ala ENST00000344576.6:c.1601A>C 7:g.55161601A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-AM-5821-01 1651151 1565938 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV99291226 COSM7552389 104576692 c.1124C>T p.A375V Substitution - Missense 38 7:55156650-55156650 + - PATHOGENIC .98971 Confirmed somatic variant 376 NS NS 68 ENSP00000345973.2:p.Ala375Val ENST00000344576.6:c.1124C>T 7:g.55156650C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009852-T01-IM5 2725690 2584511 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51768139 COSM21685 104563335 c.866C>A p.A289D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Asp ENST00000344576.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0004400-T01-IM5 2720811 2579632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 EX01T 2653305 2513432 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS primary 58.5 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 96737 1973055 1859299 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSV51777851 COSM1205052 104571359 c.494G>A p.R165Q Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .0375 Confirmed somatic variant 23680147 surgery - NOS primary ENSP00000345973.2:p.Arg165Gln ENST00000344576.6:c.494G>A 7:g.55146675G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-85-8287-01 2195185 2063463 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99292034 COSM8786620 104569649 c.1924A>G p.K642E Substitution - Missense 38 7:55170350-55170350 + - NEUTRAL .01194 Confirmed somatic variant 418 NS NS 72 ENSP00000345973.2:p.Lys642Glu ENST00000344576.6:c.1924A>G 7:g.55170350A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-OL-A5RZ-01 2187696 2055974 breast NS NS NS carcinoma NS NS NS y COSV99288978 COSM7695792 104572252 c.289G>C p.E97Q Substitution - Missense 38 7:55143353-55143353 + - PATHOGENIC .94007 Confirmed somatic variant 414 NS NS 57 ENSP00000345973.2:p.Glu97Gln ENST00000344576.6:c.289G>C 7:g.55143353G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 14_S4 2902121 2756359 autonomic_ganglia NS NS NS neuroblastoma NS NS NS n COSV105863896 COSM9976114 104571834 c.818C>G p.T273S Substitution - Missense 38 7:55154081-55154081 + - PATHOGENIC .94747 Confirmed somatic variant 33381456 circulating tumour primary 7 ENSP00000345973.2:p.Thr273Ser ENST00000344576.6:c.818C>G 7:g.55154081C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0004944-T02-IM5 2721354 2580175 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843300 COSM6949613 104581176 c.937G>T p.A313S Substitution - Missense het 38 7:55155877-55155877 + - NEUTRAL .06397 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000345973.2:p.Ala313Ser ENST00000344576.6:c.937G>T 7:g.55155877G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SJALL040461-R 2824036 2679864 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV104576718 COSM9280424 104568673 c.1592G>A p.R531Q Substitution - Missense 38 7:55161592-55161592 + - PATHOGENIC .99386 Confirmed somatic variant 31697823 blood-bone marrow recurrent 11.64 ENSP00000345973.2:p.Arg531Gln ENST00000344576.6:c.1592G>A 7:g.55161592G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 Br143X 1473036 1396735 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51776043 COSM54529 104564835 c.1957A>T p.S653C Substitution - Missense het 38 7:55170383-55170383 + - NEUTRAL .01222 Confirmed somatic variant 326 xenograft NS 47 ENSP00000345973.2:p.Ser653Cys ENST00000344576.6:c.1957A>T 7:g.55170383A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 Br124X 1313013 1223922 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 xenograft primary 44 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 587342 1766789 1671109 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51777851 COSM1205052 104571359 c.494G>A p.R165Q Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .0375 Confirmed somatic variant 22895193 surgery fresh/frozen primary ENSP00000345973.2:p.Arg165Gln ENST00000344576.6:c.494G>A 7:g.55146675G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0004688-T01-IM5 2721089 2579910 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51823965 COSM6937748 104576026 c.76G>A p.E26K Substitution - Missense het 38 7:55019353-55019353 + - PATHOGENIC .70393 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Glu26Lys ENST00000344576.6:c.76G>A 7:g.55019353G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003108-T01-IM5 2829558 2685373 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51866279 COSM6926300 104564036 c.665G>A p.R222H Substitution - Missense 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 30205045 surgery-fixed metastasis 37 ENSP00000345973.2:p.Arg222His ENST00000344576.6:c.665G>A 7:g.55152582G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1022 2491916 2354545 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS y COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 26437033 surgery fresh/frozen NS 55 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T3010 2658443 2518602 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 104566531 c.1580G>A p.R527Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 74.08 ENSP00000345973.2:p.Arg527Gln ENST00000344576.6:c.1580G>A 7:g.55161580G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-2563-01 1337882 1248267 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 104565122 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000345973.2:p.Arg252Cys ENST00000344576.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-EE-A2MR-06 2121688 1995924 skin NS NS NS malignant_melanoma NS NS NS y COSV51788720 COSM3639737 104588405 c.1534C>T p.P512S Substitution - Missense 38 7:55161534-55161534 + - NEUTRAL .03494 Confirmed somatic variant 540 NS NS 61 ENSP00000345973.2:p.Pro512Ser ENST00000344576.6:c.1534C>T 7:g.55161534C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-19-5956-01 2178192 2046490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99292946 COSM7469776 104588086 c.461C>A p.P154H Substitution - Missense 38 7:55146642-55146642 + - PATHOGENIC .80234 Confirmed somatic variant 329 NS NS 53 ENSP00000345973.2:p.Pro154His ENST00000344576.6:c.461C>A 7:g.55146642C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-76-6282-01 2120389 1994625 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51810174 COSM3412190 104565872 c.1712G>C p.C571S Substitution - Missense 38 7:55163813-55163813 + - PATHOGENIC .99637 Confirmed somatic variant 329 NS NS 63 ENSP00000345973.2:p.Cys571Ser ENST00000344576.6:c.1712G>C 7:g.55163813G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 J80_T 2194988 2063266 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51805367 COSM3950642 104578352 c.1039G>A p.D347N Substitution - Missense 38 7:55156565-55156565 + - PATHOGENIC .82248 Confirmed somatic variant 583 NS NS ENSP00000345973.2:p.Asp347Asn ENST00000344576.6:c.1039G>A 7:g.55156565G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PCA1587 2861424 2716668 prostate NS NS NS carcinoma NS NS NS n COSV105111146 COSM9581090 104592864 c.1879G>C p.G627R Substitution - Missense 38 7:55165436-55165436 + - PATHOGENIC .99177 Confirmed somatic variant 32268276 circulating tumour NS ENSP00000345973.2:p.Gly627Arg ENST00000344576.6:c.1879G>C 7:g.55165436G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0011544-T01-IM5 2727116 2585937 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51774354 COSM6981709 104593801 c.951G>C p.E317D Substitution - Missense het 38 7:55155891-55155891 + - PATHOGENIC .93673 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Glu317Asp ENST00000344576.6:c.951G>C 7:g.55155891G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-28-1757-01 2178083 2046381 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99292943 COSM7465417 104577495 c.2005G>A p.G669R Substitution - Missense 38 7:55170431-55170431 + - NEUTRAL .00065 Confirmed somatic variant 329 NS NS 71 ENSP00000345973.2:p.Gly669Arg ENST00000344576.6:c.2005G>A 7:g.55170431G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0002659-T01-IM3 2718905 2577726 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51775381 COSM6923532 104586243 c.1049C>G p.S350C Substitution - Missense het 38 7:55156575-55156575 + - PATHOGENIC .99062 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Ser350Cys ENST00000344576.6:c.1049C>G 7:g.55156575C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-GN-A265-06 2121795 1996031 skin NS NS NS malignant_melanoma NS NS NS y COSV99285452 COSM8070350 104585891 c.1886G>A p.G629E Substitution - Missense 38 7:55170312-55170312 + - NEUTRAL .01695 Confirmed somatic variant 540 NS NS 53 ENSP00000345973.2:p.Gly629Glu ENST00000344576.6:c.1886G>A 7:g.55170312G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-2565-01 1337884 1248269 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DU-A5TT-01 2194423 2062701 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 70 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0005725-T01-IM5 2722109 2580930 NS NS NS NS malignant_melanoma NS NS NS n COSV51776559 COSM4892884 104565414 c.298C>T p.P100S Substitution - Missense het 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000345973.2:p.Pro100Ser ENST00000344576.6:c.298C>T 7:g.55143362C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-2567-01 1337886 1248271 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51816377 COSM3412194 104562097 c.1786C>T p.P596S Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99531 Confirmed somatic variant 329 surgery fresh/frozen NS 65 ENSP00000345973.2:p.Pro596Ser ENST00000344576.6:c.1786C>T 7:g.55165343C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 B103-S1 2732514 2591270 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV104576423 COSM9498532 104566181 c.1701G>T p.M567I Substitution - Missense 38 7:55163802-55163802 + - PATHOGENIC .93931 Confirmed somatic variant 29244145 surgery fresh/frozen primary 74.3 ENSP00000345973.2:p.Met567Ile ENST00000344576.6:c.1701G>T 7:g.55163802G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-B5-A11E-01 1783399 1687398 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99287802 COSM9037443 104588338 c.529T>C p.S177P Substitution - Missense 38 7:55146710-55146710 + - NEUTRAL .17589 Confirmed somatic variant 419 fresh/frozen - NOS primary 53 ENSP00000345973.2:p.Ser177Pro ENST00000344576.6:c.529T>C 7:g.55146710T>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 Br140X 1313029 1223938 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 xenograft primary 41 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P147 2072600 1951955 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 44 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1461 2602435 2463311 large_intestine right NS NS carcinoma adenocarcinoma NS NS n COSV51813913 COSM6023901 104566020 c.344A>C p.N115T Substitution - Missense 38 7:55143408-55143408 + - PATHOGENIC .92454 Confirmed somatic variant 27121310 surgery fresh/frozen NS 47 ENSP00000345973.2:p.Asn115Thr ENST00000344576.6:c.344A>C 7:g.55143408A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0004400-T01-IM5 2720811 2579632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0004510-T01-IM5 2720910 2579731 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-OX-A56R-01 2178260 2046558 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 68 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 s_DS_scb_02_tumour 2861572 2716810 urinary_tract bladder NS NS carcinoma small_cell_carcinoma NS NS n COSV105109947 COSM9575249 104572688 c.673G>A p.G225S Substitution - Missense 38 7:55152590-55152590 + - PATHOGENIC .99676 Confirmed somatic variant 29180607 surgery-fixed NS 68 ENSP00000345973.2:p.Gly225Ser ENST00000344576.6:c.673G>A 7:g.55152590G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 LICA-CN-HCC131T 2634178 2494574 liver NS NS NS other neoplasm NS NS y COSV51799496 COSM5824594 104576088 c.244A>T p.I82F Substitution - Missense 38 7:55143308-55143308 + - PATHOGENIC .99415 Confirmed somatic variant 660 NS primary 49 ENSP00000345973.2:p.Ile82Phe ENST00000344576.6:c.244A>T 7:g.55143308A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-28-1757-01 2178083 2046381 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 71 ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T1748 2658268 2518427 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51796395 COSM6652238 104589888 c.1244C>T p.T415M Substitution - Missense 38 7:55157699-55157699 + - PATHOGENIC .97374 Confirmed somatic variant 27149842 NS NS 85.08 ENSP00000345973.2:p.Thr415Met ENST00000344576.6:c.1244C>T 7:g.55157699C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PTC-7C 2185970 2054267 thyroid NS NS NS other neoplasm NS NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 589 NS NS ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-12-0707-01 2178095 2046393 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 104564353 c.809A>G p.Y270C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 329 NS NS 55 ENSP00000345973.2:p.Tyr270Cys ENST00000344576.6:c.809A>G 7:g.55154072A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009459-T01-IM5 2725386 2584207 testis NS NS NS germ_cell_tumour mixed NS NS n COSV51822613 COSM6968786 104568581 c.92G>T p.C31F Substitution - Missense het 38 7:55142289-55142289 + - PATHOGENIC .99814 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Cys31Phe ENST00000344576.6:c.92G>T 7:g.55142289G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0008346-T01-IM5 2830127 2685942 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51838649 COSM6962468 104583035 c.412A>G p.R138G Substitution - Missense 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 30205045 surgery-fixed primary 61 ENSP00000345973.2:p.Arg138Gly ENST00000344576.6:c.412A>G 7:g.55143476A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 19T 2745856 2604559 liver NS NS NS other neoplasm NS NS y COSV51840438 COSM1727959 104571572 c.374A>G p.Y125C Substitution - Missense 38 7:55143438-55143438 + - PATHOGENIC .99088 Confirmed somatic variant 660 NS primary 71 ENSP00000345973.2:p.Tyr125Cys ENST00000344576.6:c.374A>G 7:g.55143438A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003393-T01-IM5 2829603 2685418 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51792310 COSM6928197 104565568 c.50C>T p.A17V Substitution - Missense 38 7:55019327-55019327 + - NEUTRAL .01177 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000345973.2:p.Ala17Val ENST00000344576.6:c.50C>T 7:g.55019327C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1894611 1894611 1783303 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51837871 COSM1238072 104596173 c.1636C>T p.P546S Substitution - Missense hom 38 7:55163737-55163737 + - PATHOGENIC .99252 Confirmed somatic variant 23578570 surgery-fixed NS 33 ENSP00000345973.2:p.Pro546Ser ENST00000344576.6:c.1636C>T 7:g.55163737C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV104369000 COSM9233361 104580339 c.352G>T p.A118S Substitution - Missense het 38 7:55143416-55143416 + - PATHOGENIC .99878 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000345973.2:p.Ala118Ser ENST00000344576.6:c.352G>T 7:g.55143416G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003350-T01-IM5 2719841 2578662 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51815967 COSM39522 104563273 c.655T>G p.C219G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Cys219Gly ENST00000344576.6:c.655T>G 7:g.55152572T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-EE-A2M7-06 2121673 1995909 skin NS NS NS malignant_melanoma NS NS NS y COSV51790699 COSM3639729 104574303 c.791G>A p.C264Y Substitution - Missense 38 7:55154054-55154054 + - PATHOGENIC .99369 Confirmed somatic variant 540 NS NS 66 ENSP00000345973.2:p.Cys264Tyr ENST00000344576.6:c.791G>A 7:g.55154054G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2876654 2876654 2731169 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 circulating tumour NS 63 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0002999-T01-IM3 2719208 2578029 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 104566152 c.755G>A p.R252H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg252His ENST00000344576.6:c.755G>A 7:g.55154018G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003739-T01-IM5 2720227 2579048 soft_tissue blood_vessel skin NS angiosarcoma NS NS NS n COSV51783517 COSM3639743 104561158 c.1864C>T p.P622S Substitution - Missense het 38 7:55165421-55165421 + - NEUTRAL .20892 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Pro622Ser ENST00000344576.6:c.1864C>T 7:g.55165421C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-BA-6872-01 2193616 2061894 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99294544 COSM8387616 104572182 c.571G>A p.D191N Substitution - Missense 38 7:55151305-55151305 + - PATHOGENIC .93234 Confirmed somatic variant 627 NS NS 47 ENSP00000345973.2:p.Asp191Asn ENST00000344576.6:c.571G>A 7:g.55151305G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-EE-A2MI-06 2121680 1995916 skin NS NS NS malignant_melanoma NS NS NS y COSV51783517 COSM3639743 104561158 c.1864C>T p.P622S Substitution - Missense 38 7:55165421-55165421 + - NEUTRAL .20892 Confirmed somatic variant 540 NS NS 43 ENSP00000345973.2:p.Pro622Ser ENST00000344576.6:c.1864C>T 7:g.55165421C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577025 COSM9413133 104596665 c.1326C>G p.S442R Substitution - Missense 38 7:55160166-55160166 + - NEUTRAL .15107 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000345973.2:p.Ser442Arg ENST00000344576.6:c.1326C>G 7:g.55160166C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0005127-T01-IM5 2721532 2580353 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51794869 COSM4362780 104563015 c.574C>T p.P192S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000345973.2:p.Pro192Ser ENST00000344576.6:c.574C>T 7:g.55151308C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PCSI_0590_Pa_P_526 2507081 2369417 pancreas NS NS NS carcinoma NS NS NS y COSV51771539 COSM5760860 104595188 c.1705A>G p.I569V Substitution - Missense 38 7:55163806-55163806 + - NEUTRAL .01956 Confirmed somatic variant 382 NS primary 73 ENSP00000345973.2:p.Ile569Val ENST00000344576.6:c.1705A>G 7:g.55163806A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003393-T01-IM5 2719877 2578698 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51792310 COSM6928197 104565568 c.50C>T p.A17V Substitution - Missense het 38 7:55019327-55019327 + - NEUTRAL .01177 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Ala17Val ENST00000344576.6:c.50C>T 7:g.55019327C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 YUKLAB 2013569 1896201 skin NS NS NS malignant_melanoma NS NS NS y COSV51796177 COSM1698689 104583905 c.1189A>T p.T397S Substitution - Missense het 38 7:55156814-55156814 + - PATHOGENIC .9893 Confirmed somatic variant 22842228 surgery fresh/frozen metastasis 84 ENSP00000345973.2:p.Thr397Ser ENST00000344576.6:c.1189A>T 7:g.55156814A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2625883 2625883 2486295 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51796381 COSM6191457 104589880 c.1867A>T p.N623Y Substitution - Missense 38 7:55165424-55165424 + - PATHOGENIC .99705 Confirmed somatic variant 25617745 surgery-fixed NS 61 ENSP00000345973.2:p.Asn623Tyr ENST00000344576.6:c.1867A>T 7:g.55165424A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-12-3650-01 2120284 1994520 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 46 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-12-3650-01 2120284 1994520 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51845825 COSM3412188 104567230 c.1280G>T p.R427L Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .99702 Confirmed somatic variant 329 NS NS 46 ENSP00000345973.2:p.Arg427Leu ENST00000344576.6:c.1280G>T 7:g.55157735G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MELA_0013 2837859 2693634 skin mucosal female_genitourinary_system NS malignant_melanoma NS NS NS y COSV104576941 COSM9347976 104564071 c.1978A>T p.S660C Substitution - Missense 38 7:55170404-55170404 + - NEUTRAL .0077 Confirmed somatic variant 31320640 surgery fresh/frozen primary 46 ENSP00000345973.2:p.Ser660Cys ENST00000344576.6:c.1978A>T 7:g.55170404A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-14-0786-01 1337986 1248371 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0010967-T01-IM5 2726608 2585429 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51856949 COSM6978220 104594108 c.413G>T p.R138I Substitution - Missense het 38 7:55143477-55143477 + - PATHOGENIC .94211 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg138Ile ENST00000344576.6:c.413G>T 7:g.55143477G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0005127-T01-IM5 2721532 2580353 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51802355 COSM6941144 104563038 c.1154C>T p.P385L Substitution - Missense het 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000345973.2:p.Pro385Leu ENST00000344576.6:c.1154C>T 7:g.55156779C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-AA-3982-01 1651089 1565876 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51769747 COSM297803 104579537 c.907G>C p.D303H Substitution - Missense 38 7:55155847-55155847 + - PATHOGENIC .99461 Confirmed somatic variant 22810696 376 NS NS 75 ENSP00000345973.2:p.Asp303His ENST00000344576.6:c.907G>C 7:g.55155847G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 5-VS037-T3 2869864 2724861 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV105110397 COSM9764796 104564098 c.1964C>T p.S655F Substitution - Missense 38 7:55170390-55170390 + - NEUTRAL .00381 Confirmed somatic variant 26950094 surgery fresh/frozen NS 83 ENSP00000345973.2:p.Ser655Phe ENST00000344576.6:c.1964C>T 7:g.55170390C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0008927-T01-IM5 2724943 2583764 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51767495 COSM35752 104565122 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg252Cys ENST00000344576.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 104569429 c.1391C>T p.S464L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000345973.2:p.Ser464Leu ENST00000344576.6:c.1391C>T 7:g.55160231C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0007813-T01-IM5 2724038 2582859 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767730 COSM6548312 104565542 c.662G>T p.G221V Substitution - Missense het 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000345973.2:p.Gly221Val ENST00000344576.6:c.662G>T 7:g.55152579G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0001328-T01-IM3 2717084 2575905 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51833335 COSM6916442 104569721 c.14G>C p.G5A Substitution - Missense het 38 7:55019291-55019291 + - NEUTRAL .0753 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Gly5Ala ENST00000344576.6:c.14G>C 7:g.55019291G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S001073 1027682 944658 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 18195 2422953 2285875 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV51779680 COSM1313184 104577433 c.1151C>G p.T384S Substitution - Missense 38 7:55156776-55156776 + - PATHOGENIC .98418 Confirmed somatic variant 24469795 NS NS 61 ENSP00000345973.2:p.Thr384Ser ENST00000344576.6:c.1151C>G 7:g.55156776C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006622-T01-IM5 2829996 2685811 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51845994 COSM5530405 104561700 c.1633G>A p.E545K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 30205045 surgery-fixed primary 43 ENSP00000345973.2:p.Glu545Lys ENST00000344576.6:c.1633G>A 7:g.55163734G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S06-38853-TP 2366573 2229456 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51796296 COSM4992967 104588132 c.1640G>A p.R547K Substitution - Missense het 38 7:55163741-55163741 + - PATHOGENIC .992 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000345973.2:p.Arg547Lys ENST00000344576.6:c.1640G>A 7:g.55163741G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-RD-A7BT-01 2263044 2130028 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99295752 COSM8178996 104574975 c.715G>A p.G239S Substitution - Missense 38 7:55152632-55152632 + - PATHOGENIC .99504 Confirmed somatic variant 541 NS primary 66 ENSP00000345973.2:p.Gly239Ser ENST00000344576.6:c.715G>A 7:g.55152632G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577026 COSM9413136 104596670 c.1393G>C p.G465R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .4176 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000345973.2:p.Gly465Arg ENST00000344576.6:c.1393G>C 7:g.55160233G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-C5-A8XK-01 2263326 2130310 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99291070 COSM8645816 104582394 c.1993G>C p.E665Q Substitution - Missense 38 7:55170419-55170419 + - NEUTRAL .04587 Confirmed somatic variant 415 NS primary 30 ENSP00000345973.2:p.Glu665Gln ENST00000344576.6:c.1993G>C 7:g.55170419G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0004837-T01-IM5 2721240 2580061 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-32-1991-01 2120347 1994583 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 60 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 XHDG25C 2321255 2186409 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV51811244 COSM4767521 104564284 c.607G>A p.G203R Substitution - Missense 38 7:55151341-55151341 + - PATHOGENIC .99471 Confirmed somatic variant 24997986 NS NS 77 ENSP00000345973.2:p.Gly203Arg ENST00000344576.6:c.607G>A 7:g.55151341G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0649-01 1337849 1248234 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51791901 COSM2151461 104582224 c.991G>A p.G331R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .96902 Confirmed somatic variant 329 surgery fresh/frozen NS 73 ENSP00000345973.2:p.Gly331Arg ENST00000344576.6:c.991G>A 7:g.55155931G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577024 COSM9413134 104596662 c.1322T>A p.V441D Substitution - Missense 38 7:55160162-55160162 + - PATHOGENIC .92743 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000345973.2:p.Val441Asp ENST00000344576.6:c.1322T>A 7:g.55160162T>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S10-24679-TP 2366580 2229463 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51808100 COSM4992964 104592440 c.818C>T p.T273I Substitution - Missense het 38 7:55154081-55154081 + - PATHOGENIC .9224 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000345973.2:p.Thr273Ile ENST00000344576.6:c.818C>T 7:g.55154081C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-2563 2108004 1985865 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 104565122 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Arg252Cys ENST00000344576.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0004837-T01-IM5 2721240 2580061 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51812540 COSM1451536 104572088 c.322A>G p.R108G Substitution - Missense het 38 7:55143386-55143386 + - PATHOGENIC .72671 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Arg108Gly ENST00000344576.6:c.322A>G 7:g.55143386A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006119-T01-IM5 2722498 2581319 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51836444 COSM6948255 104591791 c.496G>A p.D166N Substitution - Missense het 38 7:55146677-55146677 + - PATHOGENIC .99816 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Asp166Asn ENST00000344576.6:c.496G>A 7:g.55146677G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GBM7-I2 2813444 2669836 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99293015 COSM9210724 104572620 c.1871G>C p.C624S Substitution - Missense 38 7:55165428-55165428 + - PATHOGENIC .99908 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000345973.2:p.Cys624Ser ENST00000344576.6:c.1871G>C 7:g.55165428G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-EE-A29D-06 2121635 1995871 skin NS NS NS malignant_melanoma NS NS NS y COSV51799159 COSM747427 104574797 c.1766C>T p.P589L Substitution - Missense 38 7:55165323-55165323 + - PATHOGENIC .95834 Confirmed somatic variant 540 NS NS 87 ENSP00000345973.2:p.Pro589Leu ENST00000344576.6:c.1766C>T 7:g.55165323C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 104563335 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000345973.2:p.Ala289Asp ENST00000344576.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-EE-A17X-06 2121618 1995854 skin NS NS NS malignant_melanoma NS NS NS y COSV51781835 COSM174732 104564456 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 540 NS NS 54 ENSP00000345973.2:p.Glu114Lys ENST00000344576.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2503528 2503528 2365878 autonomic_ganglia sinonasal_and_nasal_cavity NS NS olfactory_neuroblastoma NS NS NS n COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense het 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 27149458 surgery - NOS NS 44 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-AM-5820-01 1651150 1565937 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 376 NS NS 59 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MTP18_T2 2875798 2730360 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 32796935 surgery-fixed NS 74 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PD7044a 1504255 1427133 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51826432 COSM4384121 104582264 c.1570G>A p.V524I Substitution - Missense 38 7:55161570-55161570 + - PATHOGENIC .78109 Confirmed somatic variant 24030381 NS NS ENSP00000345973.2:p.Val524Ile ENST00000344576.6:c.1570G>A 7:g.55161570G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0005370-T01-IM5 2721774 2580595 skin NS NS NS malignant_melanoma NS NS NS n COSV51794869 COSM4362780 104563015 c.574C>T p.P192S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Pro192Ser ENST00000344576.6:c.574C>T 7:g.55151308C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0004225-T01-IM5 2720632 2579453 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV51771772 COSM6934070 104596466 c.1299T>A p.H433Q Substitution - Missense het 38 7:55160139-55160139 + - PATHOGENIC .93122 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.His433Gln ENST00000344576.6:c.1299T>A 7:g.55160139T>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-BR-4256-01 2198141 2066419 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51797215 COSM145360 104567668 c.967G>A p.V323I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 541 NS NS 80 ENSP00000345973.2:p.Val323Ile ENST00000344576.6:c.967G>A 7:g.55155907G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0005051-T01-IM5 2721455 2580276 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-AR-A2LR-01 2187807 2056085 breast NS NS NS carcinoma NS NS NS y COSV51781835 COSM174732 104564456 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 414 NS NS 49 ENSP00000345973.2:p.Glu114Lys ENST00000344576.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DU-7292-01 2194421 2062699 central_nervous_system brain NS NS glioma NS NS NS y COSV51800797 COSM3412178 104567250 c.755G>C p.R252P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 545 NS NS 69 ENSP00000345973.2:p.Arg252Pro ENST00000344576.6:c.755G>C 7:g.55154018G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-CV-7252-01 2193523 2061801 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 627 NS NS 62 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006437-T01-IM5 2722813 2581634 skin NS NS NS adnexal_tumour malignant_adnexal_tumour NS NS n COSV51788796 COSM4680390 104574158 c.293G>A p.R98Q Substitution - Missense het 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg98Gln ENST00000344576.6:c.293G>A 7:g.55143357G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0000154-T01-IM3 2714713 2573534 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51819471 COSM6909030 104573169 c.1273A>C p.I425L Substitution - Missense het 38 7:55157728-55157728 + - PATHOGENIC .99224 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ile425Leu ENST00000344576.6:c.1273A>C 7:g.55157728A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0007018-T01-IM5 2723393 2582214 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765787 COSM2149971 104564009 c.910C>T p.H304Y Substitution - Missense het 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.His304Tyr ENST00000344576.6:c.910C>T 7:g.55155850C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MELA_20076 2760731 2619264 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 104564846 c.1168C>A p.Q390K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 30178487 surgery fresh/frozen metastasis 30 ENSP00000345973.2:p.Gln390Lys ENST00000344576.6:c.1168C>A 7:g.55156793C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-EE-A3AB-06 2121693 1995929 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 104564846 c.1168C>A p.Q390K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 540 NS NS 30 ENSP00000345973.2:p.Gln390Lys ENST00000344576.6:c.1168C>A 7:g.55156793C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-26-1439-01 2120320 1994556 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 63 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0125-02 2120245 1994481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 64 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51776247 COSM6110417 104570504 c.1393G>A p.G465R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000345973.2:p.Gly465Arg ENST00000344576.6:c.1393G>A 7:g.55160233G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 RS33T 2653643 2513765 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS primary 67.09 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2014_Lung_sq_06_T 2744877 2603580 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 77 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DD-A73A-01 2194652 2062930 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51846765 COSM4916543 104565392 c.1232C>G p.P411R Substitution - Missense 38 7:55157687-55157687 + - PATHOGENIC .99735 Confirmed somatic variant 628 NS NS 71 ENSP00000345973.2:p.Pro411Arg ENST00000344576.6:c.1232C>G 7:g.55157687C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2757166 2757166 2615808 haematopoietic_and_lymphoid_tissue skin NS NS lymphoid_neoplasm mycosis_fungoides-Sezary_syndrome NS NS y COSV104576496 COSM9308820 104587464 c.1246G>A p.D416N Substitution - Missense 38 7:55157701-55157701 + - PATHOGENIC .96223 Confirmed somatic variant 26551670 blood-bone marrow secondary ENSP00000345973.2:p.Asp416Asn ENST00000344576.6:c.1246G>A 7:g.55157701G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 EXTERN_MELA_20140514_002 2839308 2695074 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51866168 COSM3266611 104572668 c.1840G>A p.G614S Substitution - Missense 38 7:55165397-55165397 + - NEUTRAL .00559 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000345973.2:p.Gly614Ser ENST00000344576.6:c.1840G>A 7:g.55165397G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-D3-A2JC-06 2121515 1995751 skin NS NS NS malignant_melanoma NS NS NS y COSV99292283 COSM7860401 104568052 c.1975G>T p.G659W Substitution - Missense 38 7:55170401-55170401 + - NEUTRAL .00854 Confirmed somatic variant 540 NS NS 53 ENSP00000345973.2:p.Gly659Trp ENST00000344576.6:c.1975G>T 7:g.55170401G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0008927-T01-IM5 2724943 2583764 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51768139 COSM21685 104563335 c.866C>A p.A289D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Asp ENST00000344576.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GBM7-I1 2813443 2669835 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0010130-T01-IM5 2725937 2584758 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51788796 COSM4680390 104574158 c.293G>A p.R98Q Substitution - Missense het 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Arg98Gln ENST00000344576.6:c.293G>A 7:g.55143357G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 R074-R1 2813496 2669888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99297135 COSM9212199 104571950 c.865G>T p.A289S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 41 ENSP00000345973.2:p.Ala289Ser ENST00000344576.6:c.865G>T 7:g.55154128G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-AX-A06F-01 2198328 2066606 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99294241 COSM8943299 104582318 c.710C>A p.A237D Substitution - Missense 38 7:55152627-55152627 + - PATHOGENIC .99353 Confirmed somatic variant 419 NS NS 59 ENSP00000345973.2:p.Ala237Asp ENST00000344576.6:c.710C>A 7:g.55152627C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CHG-12-12649T 2634294 2494690 liver NS NS NS other neoplasm NS NS y COSV51767687 COSM6191352 104561335 c.1747G>A p.A583T Substitution - Missense 38 7:55165304-55165304 + - PATHOGENIC .98656 Confirmed somatic variant 660 NS primary 50 ENSP00000345973.2:p.Ala583Thr ENST00000344576.6:c.1747G>A 7:g.55165304G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003417-T01-IM5 2719901 2578722 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS n COSV51815967 COSM39522 104563273 c.655T>G p.C219G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Cys219Gly ENST00000344576.6:c.655T>G 7:g.55152572T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0005378-T01-IM5 2721782 2580603 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51862161 COSM6943352 104561370 c.73C>G p.L25V Substitution - Missense het 38 7:55019350-55019350 + - NEUTRAL .21138 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Leu25Val ENST00000344576.6:c.73C>G 7:g.55019350C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 171T 2473937 2336707 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 26489445 fixed - NOS NS ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0001042-T01-IM3 2716511 2575332 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577028 COSM9413137 104596690 c.1472T>A p.I491K Substitution - Missense 38 7:55160312-55160312 + - NEUTRAL .08768 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000345973.2:p.Ile491Lys ENST00000344576.6:c.1472T>A 7:g.55160312T>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GBM_IV-35 2354292 2218450 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 pfg043T 2309624 2174826 stomach NS NS NS carcinoma intestinal_adenocarcinoma NS NS y COSV51790826 COSM4755611 104564385 c.566A>C p.K189T Substitution - Missense het 38 7:55151300-55151300 + - PATHOGENIC .93585 Confirmed somatic variant 24816253 surgery fresh/frozen NS 76 ENSP00000345973.2:p.Lys189Thr ENST00000344576.6:c.566A>C 7:g.55151300A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 Br306T 1313064 1223973 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 surgery - NOS primary 51 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0001248-T01-IM3 2716920 2575741 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51855488 COSM4166393 104569570 c.710C>T p.A237V Substitution - Missense het 38 7:55152627-55152627 + - PATHOGENIC .99229 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Ala237Val ENST00000344576.6:c.710C>T 7:g.55152627C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 R056-R1 2813482 2669874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289246 COSM8268187 104564057 c.788C>T p.T263I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 42 ENSP00000345973.2:p.Thr263Ile ENST00000344576.6:c.788C>T 7:g.55154051C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194735 1194735 1106630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-16-0849-01 2178109 2046407 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 54 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 123 2748095 2606798 stomach NS NS NS carcinoma NS NS NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 683 NS primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GBM7-I2 2813444 2669836 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-28-5209-01 2120334 1994570 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51808387 COSM3412196 104570866 c.1793G>C p.G598A Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 329 NS NS 66 ENSP00000345973.2:p.Gly598Ala ENST00000344576.6:c.1793G>C 7:g.55165350G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PD6780a 1503990 1426868 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia_with_ringed_sideroblasts NS n COSV51791654 COSM4384111 104582422 c.95A>G p.Q32R Substitution - Missense 38 7:55142292-55142292 + - PATHOGENIC .96882 Confirmed somatic variant 24030381 NS NS ENSP00000345973.2:p.Gln32Arg ENST00000344576.6:c.95A>G 7:g.55142292A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2625883 2625883 2486295 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51796371 COSM6191453 104589874 c.203C>T p.T68I Substitution - Missense 38 7:55142400-55142400 + - PATHOGENIC .99116 Confirmed somatic variant 25617745 surgery-fixed NS 61 ENSP00000345973.2:p.Thr68Ile ENST00000344576.6:c.203C>T 7:g.55142400C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 98019 1520664 1443039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51786915 COSM94179 104568244 c.610G>A p.E204K Substitution - Missense 38 7:55151344-55151344 + - NEUTRAL .0681 Confirmed somatic variant 20668451 NS primary ENSP00000345973.2:p.Glu204Lys ENST00000344576.6:c.610G>A 7:g.55151344G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0001042-T01-IM3 2716511 2575332 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51787557 COSM6191456 104563008 c.1337C>T p.T446I Substitution - Missense het 38 7:55160177-55160177 + - NEUTRAL .13103 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Thr446Ile ENST00000344576.6:c.1337C>T 7:g.55160177C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0013704-T01-IM5 2803863 2660613 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51781835 COSM174732 104564456 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 29316426 surgery-fixed primary 71 ENSP00000345973.2:p.Glu114Lys ENST00000344576.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576891 COSM9396331 104569240 c.1400A>C p.K467T Substitution - Missense 38 7:55160240-55160240 + - NEUTRAL .10442 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000345973.2:p.Lys467Thr ENST00000344576.6:c.1400A>C 7:g.55160240A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0008262-T01-IM5 2724401 2583222 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GBM12 2144553 2013767 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 24285547 surgery fresh/frozen primary 64 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 16678 1423698 1333726 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51812036 COSM48318 104590984 c.1789G>A p.A597T Substitution - Missense het 38 7:55165346-55165346 + - NEUTRAL .27484 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000345973.2:p.Ala597Thr ENST00000344576.6:c.1789G>A 7:g.55165346G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 007 2640411 2500713 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS y COSV51815598 COSM6471954 104570792 c.1325G>T p.S442I Substitution - Missense 38 7:55160165-55160165 + - NEUTRAL .44157 Confirmed somatic variant 27545006 fixed - NOS NS 57 ENSP00000345973.2:p.Ser442Ile ENST00000344576.6:c.1325G>T 7:g.55160165G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-A6S1-01 2263260 2130244 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS primary 53 ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577027 COSM9413135 104570755 c.1394G>A p.G465E Substitution - Missense 38 7:55160234-55160234 + - NEUTRAL .11765 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000345973.2:p.Gly465Glu ENST00000344576.6:c.1394G>A 7:g.55160234G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CHC1774T 2340683 2205666 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51807517 COSM4802395 104586638 c.67C>T p.R23W Substitution - Missense 38 7:55019344-55019344 + - NEUTRAL .00803 Confirmed somatic variant 381 NS primary 65 ENSP00000345973.2:p.Arg23Trp ENST00000344576.6:c.67C>T 7:g.55019344C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0000785-T01-IM3 2715984 2574805 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767730 COSM6548312 104565542 c.662G>T p.G221V Substitution - Missense het 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Gly221Val ENST00000344576.6:c.662G>T 7:g.55152579G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 WGC003608 2785119 2645235 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS y COSV99286188 COSM7420903 104588742 c.1570G>T p.V524F Substitution - Missense 38 7:55161570-55161570 + - .6767 Confirmed somatic variant 25526346 surgery fresh/frozen primary 54 ENSP00000345973.2:p.Val524Phe ENST00000344576.6:c.1570G>T 7:g.55161570G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-D1-A2G5-01 2198276 2066554 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99295137 COSM8817249 104582847 c.1873A>G p.T625A Substitution - Missense 38 7:55165430-55165430 + - PATHOGENIC .99619 Confirmed somatic variant 419 NS NS 50 ENSP00000345973.2:p.Thr625Ala ENST00000344576.6:c.1873A>G 7:g.55165430A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 95504 1973048 1859292 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSV51812284 COSM1651737 104585786 c.821C>T p.T274M Substitution - Missense 38 7:55154084-55154084 + - PATHOGENIC .92031 Confirmed somatic variant 23680147 surgery - NOS primary ENSP00000345973.2:p.Thr274Met ENST00000344576.6:c.821C>T 7:g.55154084C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-FR-A8YC-06 2263445 2130429 skin NS NS NS malignant_melanoma NS NS NS y COSV51772860 COSM5872872 104581853 c.683C>T p.P228L Substitution - Missense 38 7:55152600-55152600 + - PATHOGENIC .99115 Confirmed somatic variant 540 NS NS 78 ENSP00000345973.2:p.Pro228Leu ENST00000344576.6:c.683C>T 7:g.55152600C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 R074-R1 2813496 2669888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 41 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 ATL020 2488648 2351297 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm adult_T_cell_lymphoma-leukaemia NS NS y COSV51770269 COSM5710629 104580615 c.1015G>A p.G339R Substitution - Missense 38 7:55156541-55156541 + - PATHOGENIC .9949 Confirmed somatic variant 26437031 NS NS 63 ENSP00000345973.2:p.Gly339Arg ENST00000344576.6:c.1015G>A 7:g.55156541G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-19-1789-01 2178219 2046517 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51850088 COSM2156010 104574771 c.1000C>T p.R334C Substitution - Missense 38 7:55155940-55155940 + - PATHOGENIC .91604 Confirmed somatic variant 329 NS NS 69 ENSP00000345973.2:p.Arg334Cys ENST00000344576.6:c.1000C>T 7:g.55155940C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 IGC-10-1053 2662337 2522461 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51767730 COSM6548312 104565542 c.662G>T p.G221V Substitution - Missense 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000345973.2:p.Gly221Val ENST00000344576.6:c.662G>T 7:g.55152579G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2772383 2772383 2630573 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV99290341 COSM7347800 104587954 c.1016G>A p.G339E Substitution - Missense 38 7:55156542-55156542 + - PATHOGENIC .99668 Confirmed somatic variant 29807833 circulating tumour NS ENSP00000345973.2:p.Gly339Glu ENST00000344576.6:c.1016G>A 7:g.55156542G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1690841 1690841 1599108 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 104568374 c.1474A>C p.S492R Substitution - Missense het 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 22270724 surgery - NOS recurrent 64 ENSP00000345973.2:p.Ser492Arg ENST00000344576.6:c.1474A>C 7:g.55160314A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 YUSCO 2013686 1896318 skin NS NS NS malignant_melanoma NS NS NS y COSV51778830 COSM1698691 104564342 c.1198G>A p.E400K Substitution - Missense het 38 7:55156823-55156823 + - PATHOGENIC .99571 Confirmed somatic variant 22842228 NS NS ENSP00000345973.2:p.Glu400Lys ENST00000344576.6:c.1198G>A 7:g.55156823G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006119-T01-IM5 2722498 2581319 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51836484 COSM6948259 104591811 c.857G>A p.S286N Substitution - Missense het 38 7:55154120-55154120 + - PATHOGENIC .95351 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Ser286Asn ENST00000344576.6:c.857G>A 7:g.55154120G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S001018 1027698 944674 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-71-8520-01 2194759 2063037 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 417 NS NS 60 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0016773-T01-IM6 2830871 2686686 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV104577017 COSM9359622 104571882 c.743G>A p.C248Y Substitution - Missense 38 7:55152660-55152660 + - PATHOGENIC .99504 Confirmed somatic variant 30205045 surgery-fixed primary 77 ENSP00000345973.2:p.Cys248Tyr ENST00000344576.6:c.743G>A 7:g.55152660G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2492701 2492701 2355316 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 104574373 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000345973.2:p.His47Tyr ENST00000344576.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006054-T01-IM5 2722434 2581255 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003705-T01-IM5 2720193 2579014 large_intestine appendix NS NS carcinoma adenocarcinoma NS NS n COSV51812036 COSM48318 104590984 c.1789G>A p.A597T Substitution - Missense het 38 7:55165346-55165346 + - NEUTRAL .27484 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Ala597Thr ENST00000344576.6:c.1789G>A 7:g.55165346G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-IR-A3LA-01 2193391 2061669 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51796224 COSM4844514 104583928 c.1648G>C p.V550L Substitution - Missense 38 7:55163749-55163749 + - PATHOGENIC .98124 Confirmed somatic variant 415 NS NS 60 ENSP00000345973.2:p.Val550Leu ENST00000344576.6:c.1648G>C 7:g.55163749G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T3174 2658322 2518481 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 104566531 c.1580G>A p.R527Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 74.41 ENSP00000345973.2:p.Arg527Gln ENST00000344576.6:c.1580G>A 7:g.55161580G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-14-2554-01 1338017 1248402 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 52 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0000657-T02-IM5 2719370 2578191 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 104570866 c.1793G>C p.G598A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Gly598Ala ENST00000344576.6:c.1793G>C 7:g.55165350G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009661-T01-IM5 2725553 2584374 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009711-T01-IM5 2725587 2584408 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-GN-A269-01 2121799 1996035 skin NS NS NS malignant_melanoma NS NS NS y COSV51823432 COSM3639727 104569298 c.701A>G p.N234S Substitution - Missense 38 7:55152618-55152618 + - PATHOGENIC .95999 Confirmed somatic variant 540 NS NS 70 ENSP00000345973.2:p.Asn234Ser ENST00000344576.6:c.701A>G 7:g.55152618A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 HCC-JP-457-T 2746985 2605688 liver NS NS NS other neoplasm NS NS y COSV51770509 COSM7191105 104580724 c.1870T>G p.C624G Substitution - Missense 38 7:55165427-55165427 + - PATHOGENIC .99836 Confirmed somatic variant 323 NS primary 77 ENSP00000345973.2:p.Cys624Gly ENST00000344576.6:c.1870T>G 7:g.55165427T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-VS-A9UA-01 2386196 2249028 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99290048 COSM8641365 104582723 c.528G>C p.M176I Substitution - Missense 38 7:55146709-55146709 + - NEUTRAL .34467 Confirmed somatic variant 415 NS primary 60 ENSP00000345973.2:p.Met176Ile ENST00000344576.6:c.528G>C 7:g.55146709G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-A2-A4S3-01 2187874 2056152 breast NS NS NS carcinoma NS NS NS y COSV51810209 COSM3833026 104564653 c.941A>G p.D314G Substitution - Missense 38 7:55155881-55155881 + - PATHOGENIC .96368 Confirmed somatic variant 414 NS NS 59 ENSP00000345973.2:p.Asp314Gly ENST00000344576.6:c.941A>G 7:g.55155881A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0001971-T01-IM3 2718279 2577100 central_nervous_system brain NS NS glioma astrocytoma NS NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-CN-4742-01 2193489 2061767 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825459 COSM122789 104567616 c.1423A>G p.I475V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Confirmed somatic variant 627 NS NS 48 ENSP00000345973.2:p.Ile475Val ENST00000344576.6:c.1423A>G 7:g.55160263A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0007994-T01-IM5 2724178 2582999 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51811471 COSM6960839 104583014 c.380C>A p.A127E Substitution - Missense het 38 7:55143444-55143444 + - NEUTRAL .44126 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Ala127Glu ENST00000344576.6:c.380C>A 7:g.55143444C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0011107-T01-IM5 2726736 2585557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1194723 1194723 1106618 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51853292 COSM29339 104587671 c.271A>C p.I91L Substitution - Missense 38 7:55143335-55143335 + - PATHOGENIC .99037 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000345973.2:p.Ile91Leu ENST00000344576.6:c.271A>C 7:g.55143335A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SF268 1998472 1883544 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 23856246 cell-line primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-OL-A97C-01 2386126 2248958 breast NS NS NS carcinoma NS NS NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 414 NS primary 67 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2696517 2696517 2555421 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28201779 surgery fresh/frozen NS 60 ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 587220 1766747 1671067 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51792177 COSM1205050 104565402 c.1279C>T p.R427C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 22895193 surgery fresh/frozen primary ENSP00000345973.2:p.Arg427Cys ENST00000344576.6:c.1279C>T 7:g.55157734C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SJHYPO052-D 2590140 2451270 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 104565402 c.1279C>T p.R427C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 23334668 blood-bone marrow NS 16.3 ENSP00000345973.2:p.Arg427Cys ENST00000344576.6:c.1279C>T 7:g.55157734C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-MV-A51V-01 2193279 2061557 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51815409 COSM7143473 104569491 c.1169A>G p.Q390R Substitution - Missense 38 7:55156794-55156794 + - NEUTRAL .3199 Confirmed somatic variant 413 NS NS 75 ENSP00000345973.2:p.Gln390Arg ENST00000344576.6:c.1169A>G 7:g.55156794A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0011219-T01-IM5 2726835 2585656 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827895 COSM3412174 104564425 c.685A>T p.S229C Substitution - Missense het 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ser229Cys ENST00000344576.6:c.685A>T 7:g.55152602A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0008257-T01-IM5 2724396 2583217 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766389 COSM43067 104576197 c.874G>T p.V292L Substitution - Missense het 38 7:55154137-55154137 + - PATHOGENIC .98997 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Val292Leu ENST00000344576.6:c.874G>T 7:g.55154137G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CRC177post 2730751 2589520 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51776247 COSM6110417 104570504 c.1393G>A p.G465R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Confirmed somatic variant 26416732 xenograft metastasis 59 ENSP00000345973.2:p.Gly465Arg ENST00000344576.6:c.1393G>A 7:g.55160233G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2372112 2372112 2234905 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_III anaplastic NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 25694352 surgery fresh/frozen NS 28 ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0000918-T01-IM3 2716255 2575076 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-EA-A410-01 2262924 2129908 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51769145 COSM3266559 104581833 c.874G>A p.V292M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 415 NS primary 51 ENSP00000345973.2:p.Val292Met ENST00000344576.6:c.874G>A 7:g.55154137G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0005889-T01-IM5 2722273 2581094 testis NS NS NS germ_cell_tumour seminoma NS NS n COSV51857848 COSM6946731 104564766 c.1454G>A p.G485D Substitution - Missense het 38 7:55160294-55160294 + - NEUTRAL .16911 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000345973.2:p.Gly485Asp ENST00000344576.6:c.1454G>A 7:g.55160294G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 APGI-AMP-2890 2866039 2721116 pancreas ampulla_of_Vater NS NS carcinoma ductal_carcinoma NS NS y COSV105111099 COSM9620623 104585244 c.661G>A p.G221R Substitution - Missense 38 7:55152578-55152578 + - NEUTRAL .36671 Confirmed somatic variant 26804919 surgery fresh/frozen NS ENSP00000345973.2:p.Gly221Arg ENST00000344576.6:c.661G>A 7:g.55152578G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-12-0670-01 2178104 2046402 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 104564298 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 NS NS 60 ENSP00000345973.2:p.Thr263Pro ENST00000344576.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-12-0670 2108025 1985886 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 104564298 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Thr263Pro ENST00000344576.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-46-3765-01 1781761 1685760 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51850921 COSM5982763 104569349 c.1879G>T p.G627W Substitution - Missense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 418 fresh/frozen - NOS primary 59 ENSP00000345973.2:p.Gly627Trp ENST00000344576.6:c.1879G>T 7:g.55165436G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-2561-01 1337880 1248265 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51841003 COSM3412168 104589629 c.445C>T p.R149W Substitution - Missense 38 7:55146626-55146626 + - PATHOGENIC .93775 Confirmed somatic variant 329 surgery fresh/frozen NS 53 ENSP00000345973.2:p.Arg149Trp ENST00000344576.6:c.445C>T 7:g.55146626C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003702-T02-IM5 2829639 2685454 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51831642 COSM1496684 104568540 c.988G>A p.E330K Substitution - Missense 38 7:55155928-55155928 + - PATHOGENIC .94538 Confirmed somatic variant 30205045 surgery-fixed metastasis 50 ENSP00000345973.2:p.Glu330Lys ENST00000344576.6:c.988G>A 7:g.55155928G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009239-T01-IM5 2725198 2584019 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51792469 COSM6967655 104573908 c.1607T>A p.V536E Substitution - Missense het 38 7:55161607-55161607 + - PATHOGENIC .99007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Val536Glu ENST00000344576.6:c.1607T>A 7:g.55161607T>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003456-T01-IM5 2719933 2578754 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 104565122 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg252Cys ENST00000344576.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-D3-A8GB-06 2262876 2129860 skin NS NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 104565424 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 540 NS NS 48 ENSP00000345973.2:p.Ser116Phe ENST00000344576.6:c.347C>T 7:g.55143411C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0000918-T01-IM3 2716255 2575076 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51799159 COSM747427 104574797 c.1766C>T p.P589L Substitution - Missense het 38 7:55165323-55165323 + - PATHOGENIC .95834 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Pro589Leu ENST00000344576.6:c.1766C>T 7:g.55165323C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-76-4927-01 2120379 1994615 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 58 ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T3265 2658621 2518780 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51815655 COSM6652276 104596542 c.913G>A p.G305S Substitution - Missense 38 7:55155853-55155853 + - PATHOGENIC .97718 Confirmed somatic variant 27149842 NS NS 74.91 ENSP00000345973.2:p.Gly305Ser ENST00000344576.6:c.913G>A 7:g.55155853G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-E1-A7YD-01 2386254 2249086 central_nervous_system brain NS NS glioma NS NS NS y COSV51785554 COSM21688 104562387 c.971G>T p.R324L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 545 NS primary 57 ENSP00000345973.2:p.Arg324Leu ENST00000344576.6:c.971G>T 7:g.55155911G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GBM12 2144553 2013767 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 24285547 surgery fresh/frozen primary 64 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003079-T01-IM5 2719588 2578409 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0010864-T01-IM5 2726533 2585354 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51864573 COSM6977465 104566611 c.1117C>T p.P373S Substitution - Missense het 38 7:55156643-55156643 + - PATHOGENIC .91736 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Pro373Ser ENST00000344576.6:c.1117C>T 7:g.55156643C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2812807 2812807 2669221 liver NS NS NS other adenoma NS NS n COSV51845994 COSM5530405 104561700 c.1633G>A p.E545K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 31189995 surgery-fixed NS 9 ENSP00000345973.2:p.Glu545Lys ENST00000344576.6:c.1633G>A 7:g.55163734G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DU-A5TY-01 2194202 2062480 central_nervous_system brain NS NS glioma NS NS NS y COSV51765897 COSM3929120 104589754 c.961G>T p.D321Y Substitution - Missense 38 7:55155901-55155901 + - PATHOGENIC .95198 Confirmed somatic variant 545 NS NS 46 ENSP00000345973.2:p.Asp321Tyr ENST00000344576.6:c.961G>T 7:g.55155901G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 88 2630342 2490726 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51769145 COSM3266559 104581833 c.874G>A p.V292M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 27756406 surgery-fixed primary 48 ENSP00000345973.2:p.Val292Met ENST00000344576.6:c.874G>A 7:g.55154137G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009451-T01-IM5 2725378 2584199 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51781835 COSM174732 104564456 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Glu114Lys ENST00000344576.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CHG-98T 2634280 2494676 liver NS NS NS other neoplasm NS NS y COSV51850174 COSM6307834 104575439 c.350A>G p.Y117C Substitution - Missense 38 7:55143414-55143414 + - PATHOGENIC .98157 Confirmed somatic variant 660 NS primary 51 ENSP00000345973.2:p.Tyr117Cys ENST00000344576.6:c.350A>G 7:g.55143414A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 5-VS098-T1 2869935 2724932 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110457 COSM9807780 104577986 c.1165C>T p.P389S Substitution - Missense 38 7:55156790-55156790 + - PATHOGENIC .99297 Confirmed somatic variant 26950094 surgery - NOS NS 84 ENSP00000345973.2:p.Pro389Ser ENST00000344576.6:c.1165C>T 7:g.55156790C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-BF-AAP2-01 2380417 2243249 skin NS NS NS malignant_melanoma NS NS NS y COSV99291585 COSM8125194 104582402 c.2047T>A p.W683R Substitution - Missense 38 7:55170473-55170473 + - NEUTRAL .00498 Confirmed somatic variant 540 NS primary 62 ENSP00000345973.2:p.Trp683Arg ENST00000344576.6:c.2047T>A 7:g.55170473T>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DU-A5TY-01 2194202 2062480 central_nervous_system brain NS NS glioma NS NS NS y COSV51765881 COSM3929118 104589746 c.949G>A p.E317K Substitution - Missense 38 7:55155889-55155889 + - PATHOGENIC .99356 Confirmed somatic variant 545 NS NS 46 ENSP00000345973.2:p.Glu317Lys ENST00000344576.6:c.949G>A 7:g.55155889G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 PD6883a 1504094 1426972 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia NS n COSV51850592 COSM4384117 104567199 c.754C>G p.R252G Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .93941 Confirmed somatic variant 24030381 NS NS ENSP00000345973.2:p.Arg252Gly ENST00000344576.6:c.754C>G 7:g.55154017C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006846-T01-IM5 2723226 2582047 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51781750 COSM6954369 104574414 c.954G>A p.M318I Substitution - Missense het 38 7:55155894-55155894 + - PATHOGENIC .91367 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Met318Ile ENST00000344576.6:c.954G>A 7:g.55155894G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836251 COSM6348839 104578904 c.1527G>T p.L509F Substitution - Missense 38 7:55161527-55161527 + - PATHOGENIC .8964 Confirmed somatic variant 660 NS primary 46 ENSP00000345973.2:p.Leu509Phe ENST00000344576.6:c.1527G>T 7:g.55161527G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003016-T01-IM3 2719225 2578046 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51839629 COSM6925694 104581014 c.389C>T p.T130I Substitution - Missense het 38 7:55143453-55143453 + - NEUTRAL .47678 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Thr130Ile ENST00000344576.6:c.389C>T 7:g.55143453C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2372112 2372112 2234905 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_III anaplastic NS n COSV51822289 COSM42977 104574512 c.315G>T p.Q105H Substitution - Missense 38 7:55143379-55143379 + - PATHOGENIC .90579 Confirmed somatic variant 25694352 surgery fresh/frozen NS 28 ENSP00000345973.2:p.Gln105His ENST00000344576.6:c.315G>T 7:g.55143379G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 5-VS018-T1 2869839 2724836 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV105110311 COSM9704130 104570433 c.1922T>A p.F641Y Substitution - Missense 38 7:55170348-55170348 + - NEUTRAL .01011 Confirmed somatic variant 26950094 surgery fresh/frozen NS 80 ENSP00000345973.2:p.Phe641Tyr ENST00000344576.6:c.1922T>A 7:g.55170348T>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51816377 COSM3412194 104562097 c.1786C>T p.P596S Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99531 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000345973.2:p.Pro596Ser ENST00000344576.6:c.1786C>T 7:g.55165343C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 YUOTHO 2439352 2302193 skin NS NS NS malignant_melanoma NS NS NS y COSV51848994 COSM5407724 104569008 c.1701G>A p.M567I Substitution - Missense het 38 7:55163802-55163802 + - PATHOGENIC .89204 Confirmed somatic variant 26214590 fresh/frozen - NOS primary 87 ENSP00000345973.2:p.Met567Ile ENST00000344576.6:c.1701G>A 7:g.55163802G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51812540 COSM1451536 104572088 c.322A>G p.R108G Substitution - Missense 38 7:55143386-55143386 + - PATHOGENIC .72671 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000345973.2:p.Arg108Gly ENST00000344576.6:c.322A>G 7:g.55143386A>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836185 COSM4884832 104578863 c.739G>T p.D247Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 660 NS primary 46 ENSP00000345973.2:p.Asp247Tyr ENST00000344576.6:c.739G>T 7:g.55152656G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51808387 COSM3412196 104570866 c.1793G>C p.G598A Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000345973.2:p.Gly598Ala ENST00000344576.6:c.1793G>C 7:g.55165350G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-FG-A87Q-01 2339613 2204596 central_nervous_system brain NS NS glioma NS NS NS y COSV99289246 COSM8268187 104564057 c.788C>T p.T263I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 545 NS primary 61 ENSP00000345973.2:p.Thr263Ile ENST00000344576.6:c.788C>T 7:g.55154051C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 DUMC-18 2748715 2607418 central_nervous_system frontoparietal NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 29802247 surgery fresh/frozen NS 52 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 23 2699404 2558308 skin NS NS NS malignant_melanoma NS NS NS n COSV51774288 COSM6906389 104568648 c.1256_1257delinsTT p.A419V Substitution - Missense het 38 7:55157711-55157712 + - Confirmed somatic variant 29420467 surgery-fixed NS ENSP00000345973.2:p.Ala419Val ENST00000344576.6:c.1256_1257delinsTT 7:g.55157711_55157712delinsTT EGFR_ENST00000344576 ENST00000344576.6 2118 3236 MSU3-c 2809980 2666642 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV99292326 COSM9176305 104577849 c.1579C>T p.R527W Substitution - Missense 38 7:55161579-55161579 + - NEUTRAL .28879 Confirmed somatic variant 26336987 surgery fresh/frozen primary 51 ENSP00000345973.2:p.Arg527Trp ENST00000344576.6:c.1579C>T 7:g.55161579C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006846-T01-IM5 2723226 2582047 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SJG-018 2561465 2422889 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS y COSV51850921 COSM5982763 104569349 c.1879G>T p.G627W Substitution - Missense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 27693639 short-term culture primary 79 ENSP00000345973.2:p.Gly627Trp ENST00000344576.6:c.1879G>T 7:g.55165436G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 5-VS034-T2 2869859 2724856 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51802355 COSM6941144 104563038 c.1154C>T p.P385L Substitution - Missense 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 26950094 surgery - NOS NS 75 ENSP00000345973.2:p.Pro385Leu ENST00000344576.6:c.1154C>T 7:g.55156779C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-EB-A431-01 2121600 1995836 skin NS NS NS malignant_melanoma NS NS NS y COSV51820698 COSM3639725 104576634 c.680C>T p.S227F Substitution - Missense 38 7:55152597-55152597 + - NEUTRAL .18615 Confirmed somatic variant 540 NS NS 34 ENSP00000345973.2:p.Ser227Phe ENST00000344576.6:c.680C>T 7:g.55152597C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T3174 2296192 2161795 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 104566531 c.1580G>A p.R527Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 25344691 NS NS 74.41 ENSP00000345973.2:p.Arg527Gln ENST00000344576.6:c.1580G>A 7:g.55161580G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S003577 1027697 944673 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 104562086 c.1787C>T p.P596L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Pro596Leu ENST00000344576.6:c.1787C>T 7:g.55165344C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003456-T01-IM5 2719933 2578754 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-QH-A6XC-01 2263268 2130252 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS primary 48 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GBM_IV-19 2354288 2218446 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0002265-T02-IM5 2719496 2578317 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009451-T01-IM5 2725378 2584199 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T1803 2658686 2518845 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51850996 COSM6652242 104569926 c.1192G>A p.V398I Substitution - Missense 38 7:55156817-55156817 + - PATHOGENIC .99161 Confirmed somatic variant 27149842 NS NS 63 ENSP00000345973.2:p.Val398Ile ENST00000344576.6:c.1192G>A 7:g.55156817G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T1154 2296082 2161685 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51814845 COSM4680396 104592513 c.1697C>T p.A566V Substitution - Missense 38 7:55163798-55163798 + - NEUTRAL .08918 Confirmed somatic variant 25344691 NS NS 68.33 ENSP00000345973.2:p.Ala566Val ENST00000344576.6:c.1697C>T 7:g.55163798C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0012402-T01-IM5 2727458 2586279 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51850996 COSM6652242 104569926 c.1192G>A p.V398I Substitution - Missense het 38 7:55156817-55156817 + - PATHOGENIC .99161 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Val398Ile ENST00000344576.6:c.1192G>A 7:g.55156817G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0211-01 1910206 1798497 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 104564298 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 fresh/frozen - NOS primary 48 ENSP00000345973.2:p.Thr263Pro ENST00000344576.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-B0-4822-01 2120426 1994662 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51848907 COSM3366976 104573347 c.976T>C p.C326R Substitution - Missense 38 7:55155916-55155916 + - PATHOGENIC .98755 Confirmed somatic variant 416 NS NS 78 ENSP00000345973.2:p.Cys326Arg ENST00000344576.6:c.976T>C 7:g.55155916T>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836217 COSM7314292 104578887 c.1414G>T p.A472S Substitution - Missense 38 7:55160254-55160254 + - PATHOGENIC .97432 Confirmed somatic variant 660 NS primary 46 ENSP00000345973.2:p.Ala472Ser ENST00000344576.6:c.1414G>T 7:g.55160254G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 LP6005334-DNA_C02 2263547 2130531 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV51834186 COSM4412457 104567307 c.1891G>A p.E631K Substitution - Missense 38 7:55170317-55170317 + - NEUTRAL .01334 Confirmed somatic variant 535 NS primary ENSP00000345973.2:p.Glu631Lys ENST00000344576.6:c.1891G>A 7:g.55170317G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0007076-T03-IM5 2723450 2582271 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS n COSV51860919 COSM6961890 104596430 c.593G>A p.S198N Substitution - Missense het 38 7:55151327-55151327 + - PATHOGENIC .89951 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Ser198Asn ENST00000344576.6:c.593G>A 7:g.55151327G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CHG-13-09220T 2634310 2494706 liver NS NS NS other neoplasm NS NS y COSV51802176 COSM6258054 104595425 c.111G>T p.K37N Substitution - Missense 38 7:55142308-55142308 + - PATHOGENIC .84286 Confirmed somatic variant 660 NS primary 67 ENSP00000345973.2:p.Lys37Asn ENST00000344576.6:c.111G>T 7:g.55142308G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0004666-T01-IM5 2721066 2579887 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 104568374 c.1474A>C p.S492R Substitution - Missense het 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000345973.2:p.Ser492Arg ENST00000344576.6:c.1474A>C 7:g.55160314A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0012360-T01-IM5 2727428 2586249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 104563671 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg108Lys ENST00000344576.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2014_Lung_sq_70_T 2744941 2603644 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 48 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CH-LA8 2211434 2079637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51855488 COSM4166393 104569570 c.710C>T p.A237V Substitution - Missense 38 7:55152627-55152627 + - PATHOGENIC .99229 Confirmed somatic variant 24449147 surgery fresh/frozen NS 67 ENSP00000345973.2:p.Ala237Val ENST00000344576.6:c.710C>T 7:g.55152627C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 SJHGG023_D 2307355 2172559 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 24705251 surgery - NOS NS 4 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-E1-A7YJ-01 2457421 2320258 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 104565122 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS primary 55 ENSP00000345973.2:p.Arg252Cys ENST00000344576.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DU-5852-01 2194247 2062525 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 104565122 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS NS 61 ENSP00000345973.2:p.Arg252Cys ENST00000344576.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0000316-T01-IM3 2715020 2573841 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792237 COSM6842523 104567641 c.829_830delinsGA p.M277E Substitution - Missense het 38 7:55154092-55154093 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Met277Glu ENST00000344576.6:c.829_830delinsGA 7:g.55154092_55154093delinsGA EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-IQ-7630-01 2193638 2061916 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51792433 COSM6966446 104579842 c.1762G>A p.G588S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 627 NS NS 49 ENSP00000345973.2:p.Gly588Ser ENST00000344576.6:c.1762G>A 7:g.55165319G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 104564009 c.910C>T p.H304Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000345973.2:p.His304Tyr ENST00000344576.6:c.910C>T 7:g.55155850C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0237 2107974 1985835 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-GN-A266-06 2121796 1996032 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 104574373 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 540 NS NS 45 ENSP00000345973.2:p.His47Tyr ENST00000344576.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T1244 2658449 2518608 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 104566531 c.1580G>A p.R527Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 62.75 ENSP00000345973.2:p.Arg527Gln ENST00000344576.6:c.1580G>A 7:g.55161580G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-F7-A624-01 2193851 2062129 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99287846 COSM8316631 104596114 c.2095A>T p.I699F Substitution - Missense 38 7:55170521-55170521 + - NEUTRAL .01185 Confirmed somatic variant 627 NS NS 73 ENSP00000345973.2:p.Ile699Phe ENST00000344576.6:c.2095A>T 7:g.55170521A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0011293-T01-IM5 2726897 2585718 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51862653 COSM6980033 104561751 c.1800G>T p.M600I Substitution - Missense het 38 7:55165357-55165357 + - PATHOGENIC .94832 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Met600Ile ENST00000344576.6:c.1800G>T 7:g.55165357G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-32-2632-01 2120352 1994588 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 104563097 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 329 NS NS 80 ENSP00000345973.2:p.Leu62Arg ENST00000344576.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-76-4926-01 2120378 1994614 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 68 ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003850-T01-IM5 2720342 2579163 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DU-8158-01 2194237 2062515 central_nervous_system brain NS NS glioma NS NS NS y COSV51771223 COSM3929114 104565620 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 545 NS NS 57 ENSP00000345973.2:p.Glu84Val ENST00000344576.6:c.251A>T 7:g.55143315A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-56-8304-01 2385872 2248704 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99294789 COSM8694245 104575014 c.259G>T p.G87C Substitution - Missense 38 7:55143323-55143323 + - PATHOGENIC .99526 Confirmed somatic variant 418 NS primary 73 ENSP00000345973.2:p.Gly87Cys ENST00000344576.6:c.259G>T 7:g.55143323G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-AA-A00N-01 1651102 1565889 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51852585 COSM274945 104568191 c.926G>A p.R309Q Substitution - Missense 38 7:55155866-55155866 + - PATHOGENIC .98601 Confirmed somatic variant 22810696 376 NS NS 75 ENSP00000345973.2:p.Arg309Gln ENST00000344576.6:c.926G>A 7:g.55155866G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 CHC892T 2340454 2205437 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51853321 COSM3412170 104581382 c.478G>A p.E160K Substitution - Missense 38 7:55146659-55146659 + - PATHOGENIC .9774 Confirmed somatic variant 381 NS primary 72 ENSP00000345973.2:p.Glu160Lys ENST00000344576.6:c.478G>A 7:g.55146659G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 ILMN12 2816772 2673123 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV104369087 COSM9238851 104579419 c.1837G>A p.A613T Substitution - Missense 38 7:55165394-55165394 + - PATHOGENIC .87498 Confirmed somatic variant 29937994 surgery fresh/frozen NS 45 ENSP00000345973.2:p.Ala613Thr ENST00000344576.6:c.1837G>A 7:g.55165394G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-AR-A0TV-01 1779493 1683492 breast NS NS NS carcinoma NS NS NS y COSV99293406 COSM7679798 104582286 c.1577G>C p.C526S Substitution - Missense 38 7:55161577-55161577 + - PATHOGENIC .9951 Confirmed somatic variant 414 fresh/frozen - NOS primary 66 ENSP00000345973.2:p.Cys526Ser ENST00000344576.6:c.1577G>C 7:g.55161577G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-EE-A3AA-06 2121692 1995928 skin NS NS NS malignant_melanoma NS NS NS y COSV99292283 COSM7860401 104568052 c.1975G>T p.G659W Substitution - Missense 38 7:55170401-55170401 + - NEUTRAL .00854 Confirmed somatic variant 540 NS NS 47 ENSP00000345973.2:p.Gly659Trp ENST00000344576.6:c.1975G>T 7:g.55170401G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006952-T01-IM5 2723330 2582151 skin NS NS NS malignant_melanoma NS NS NS n COSV51774288 COSM6906389 104568648 c.1256_1257delinsTT p.A419V Substitution - Missense het 38 7:55157711-55157712 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala419Val ENST00000344576.6:c.1256_1257delinsTT 7:g.55157711_55157712delinsTT EGFR_ENST00000344576 ENST00000344576.6 2118 3236 Au2 2466841 2329672 skin scalp NS NS malignant_melanoma desmoplastic NS NS y COSV51779748 COSM3639716 104574373 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26343386 surgery fresh/frozen NS 85 ENSP00000345973.2:p.His47Tyr ENST00000344576.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-12-0656-01 2178172 2046470 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 104563335 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 NS NS 48 ENSP00000345973.2:p.Ala289Asp ENST00000344576.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2696711 2696711 2555615 oesophagus upper_third NS NS other metaplasia epidermoid NS n COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28731047 surgery-fixed primary 62 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 DUMC-22 2748718 2607421 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51771223 COSM3929114 104565620 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 29802247 surgery fresh/frozen NS 62 ENSP00000345973.2:p.Glu84Val ENST00000344576.6:c.251A>T 7:g.55143315A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-TQ-A7RP-01 2457441 2320278 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 104565122 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS primary 66 ENSP00000345973.2:p.Arg252Cys ENST00000344576.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0009449-T01-IM5 2725376 2584197 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0005945-T01-IM5 2722328 2581149 haematopoietic_and_lymphoid_tissue lymph_node NS NS lymphoid_neoplasm follicular_lymphoma NS NS n COSV51837186 COSM1090861 104568806 c.442G>A p.V148M Substitution - Missense het 38 7:55146623-55146623 + - PATHOGENIC .99004 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000345973.2:p.Val148Met ENST00000344576.6:c.442G>A 7:g.55146623G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 BC85-ctDNA 2668219 2527792 breast NS NS NS carcinoma NS NS NS y COSV51834499 COSM6845063 104562494 c.964G>A p.G322S Substitution - Missense het 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 27535334 circulating tumour metastasis ENSP00000345973.2:p.Gly322Ser ENST00000344576.6:c.964G>A 7:g.55155904G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0154 2107952 1985813 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-AA-3811-01 1651034 1565821 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 376 NS NS 84 ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-12-0616 2108021 1985882 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-DU-7013-01 2194399 2062677 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 59 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-76-4931-01 2120382 1994618 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 70 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-HT-A5RC-01 2194260 2062538 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 70 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-EK-A3GK-01 2263412 2130396 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51793150 COSM4853861 104585685 c.2081C>G p.S694C Substitution - Missense 38 7:55170507-55170507 + - NEUTRAL .05108 Confirmed somatic variant 415 NS primary 33 ENSP00000345973.2:p.Ser694Cys ENST00000344576.6:c.2081C>G 7:g.55170507C>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 R074-I1 2813495 2669887 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99297135 COSM9212199 104571950 c.865G>T p.A289S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 28263318 surgery fresh/frozen NS 41 ENSP00000345973.2:p.Ala289Ser ENST00000344576.6:c.865G>T 7:g.55154128G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 RS40M 2653649 2513771 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 104561606 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS metastasis 41.32 ENSP00000345973.2:p.Arg521Lys ENST00000344576.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S04-45633-TP 2366567 2229450 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51801901 COSM4992959 104584833 c.448T>G p.F150V Substitution - Missense het 38 7:55146629-55146629 + - PATHOGENIC .92059 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000345973.2:p.Phe150Val ENST00000344576.6:c.448T>G 7:g.55146629T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 5-VS094-T1 2869927 2724924 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51776578 COSM4893368 104565424 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 26950094 surgery - NOS NS 84 ENSP00000345973.2:p.Ser116Phe ENST00000344576.6:c.347C>T 7:g.55143411C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0006876-T01-IM5 2723256 2582077 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 zcc203 2873641 2728634 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS y COSV99297135 COSM9212199 104571950 c.865G>T p.A289S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 33020650 surgery fresh/frozen NS ENSP00000345973.2:p.Ala289Ser ENST00000344576.6:c.865G>T 7:g.55154128G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P121 2072581 1951936 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51785554 COSM21688 104562387 c.971G>T p.R324L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 57.59 ENSP00000345973.2:p.Arg324Leu ENST00000344576.6:c.971G>T 7:g.55155911G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T660 2296260 2161863 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51781835 COSM174732 104564456 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 25344691 NS NS 66.58 ENSP00000345973.2:p.Glu114Lys ENST00000344576.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-TM-A7C3-01 2262979 2129963 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 43 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-CD-A4MG-01 2198123 2066401 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51852047 COSM3881818 104570981 c.1289C>T p.T430I Substitution - Missense 38 7:55157744-55157744 + - PATHOGENIC .99429 Confirmed somatic variant 541 NS NS 76 ENSP00000345973.2:p.Thr430Ile ENST00000344576.6:c.1289C>T 7:g.55157744C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 S001102 1027688 944664 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 104564298 c.787A>C p.T263P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000345973.2:p.Thr263Pro ENST00000344576.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-BT-A42E-01 2193275 2061553 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51814701 COSM7084541 104562721 c.361G>T p.V121F Substitution - Missense 38 7:55143425-55143425 + - PATHOGENIC .99041 Confirmed somatic variant 413 NS NS 74 ENSP00000345973.2:p.Val121Phe ENST00000344576.6:c.361G>T 7:g.55143425G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 2492700 2492700 2355315 skin face NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 104574373 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen primary ENSP00000345973.2:p.His47Tyr ENST00000344576.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 1040346 1040346 956923 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_II NS NS n COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 EOPC-126_tumor_01 2633717 2494113 prostate NS NS NS carcinoma NS NS NS y COSV51793336 COSM6214981 104582035 c.1663T>C p.C555R Substitution - Missense 38 7:55163764-55163764 + - PATHOGENIC .99407 Confirmed somatic variant 534 NS primary 47 ENSP00000345973.2:p.Cys555Arg ENST00000344576.6:c.1663T>C 7:g.55163764T>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 R074-I1 2813495 2669887 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 41 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0013010-T01-IM5 2803821 2660571 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51866279 COSM6926300 104564036 c.665G>A p.R222H Substitution - Missense het 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 29316426 surgery-fixed primary 64 ENSP00000345973.2:p.Arg222His ENST00000344576.6:c.665G>A 7:g.55152582G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-26-5139-01 2120327 1994563 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51856614 COSM3412172 104588377 c.668G>A p.C223Y Substitution - Missense 38 7:55152585-55152585 + - PATHOGENIC .99676 Confirmed somatic variant 329 NS NS 65 ENSP00000345973.2:p.Cys223Tyr ENST00000344576.6:c.668G>A 7:g.55152585G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 I2L-P16-Tumor-Organoid 2433496 2296377 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51814923 COSM5358036 104564930 c.559T>C p.C187R Substitution - Missense het 38 7:55146740-55146740 + - PATHOGENIC .98691 Confirmed somatic variant 25957691 NS NS 67 ENSP00000345973.2:p.Cys187Arg ENST00000344576.6:c.559T>C 7:g.55146740T>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0000370-T01-IM3 2715141 2573962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51849071 COSM6910043 104592200 c.831_832delinsTT p.M277_D278delinsIY Substitution - Missense het 38 7:55154094-55154095 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Met277_Asp278delinsIleTyr ENST00000344576.6:c.831_832delinsTT 7:g.55154094_55154095delinsTT EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-A8-A094-01 1779383 1683382 breast NS NS NS carcinoma NS NS NS y COSV51768800 COSM6499385 104573260 c.844G>A p.E282K Substitution - Missense 38 7:55154107-55154107 + - PATHOGENIC .81806 Confirmed somatic variant 414 fresh/frozen - NOS primary 75 ENSP00000345973.2:p.Glu282Lys ENST00000344576.6:c.844G>A 7:g.55154107G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-AA-3811-01 1651034 1565821 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51779162 COSM21689 104562086 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 376 NS NS 84 ENSP00000345973.2:p.Pro596Leu ENST00000344576.6:c.1787C>T 7:g.55165344C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-KT-A7W1-01 2262770 2129754 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 45 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 zcc203 2873641 2728634 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 33020650 surgery fresh/frozen NS ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0005303-T01-IM5 2721704 2580525 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GBM9-I2 2813459 2669851 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 104561174 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000345973.2:p.Gly598Val ENST00000344576.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0011503-T01-IM5 2727075 2585896 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 104570866 c.1793G>C p.G598A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Gly598Ala ENST00000344576.6:c.1793G>C 7:g.55165350G>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-14-1827-01 2178235 2046533 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99295901 COSM7467664 104588284 c.368C>T p.S123F Substitution - Missense 38 7:55143432-55143432 + - PATHOGENIC .82087 Confirmed somatic variant 329 NS NS 51 ENSP00000345973.2:p.Ser123Phe ENST00000344576.6:c.368C>T 7:g.55143432C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0005852-T02-IM5 2722238 2581059 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GBM9-I2 2813459 2669851 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T116 2658237 2518396 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51773524 COSM1090858 104562705 c.418T>G p.L140V Substitution - Missense 38 7:55143482-55143482 + - NEUTRAL .25717 Confirmed somatic variant 27149842 NS NS 52.58 ENSP00000345973.2:p.Leu140Val ENST00000344576.6:c.418T>G 7:g.55143482T>G EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-06-0878-01 1337866 1248251 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 104561332 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 74 ENSP00000345973.2:p.Ala289Thr ENST00000344576.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 EXTERN_MELA_20140505_023 2839407 2695173 skin mucosal vulva NS malignant_melanoma NS NS NS y COSV104576941 COSM9347976 104564071 c.1978A>T p.S660C Substitution - Missense 38 7:55170404-55170404 + - NEUTRAL .0077 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000345973.2:p.Ser660Cys ENST00000344576.6:c.1978A>T 7:g.55170404A>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0010107-T01-IM5 2725918 2584739 genital_tract extragonadal soft_tissue NS germ_cell_tumour yolk_sac_tumour NS NS n COSV51834570 COSM6972645 104567408 c.1855C>A p.L619M Substitution - Missense het 38 7:55165412-55165412 + - PATHOGENIC .9982 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000345973.2:p.Leu619Met ENST00000344576.6:c.1855C>A 7:g.55165412C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 T116 2658237 2518396 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51787894 COSM6652229 104580905 c.84G>T p.K28N Substitution - Missense 38 7:55019361-55019361 + - NEUTRAL .32765 Confirmed somatic variant 27149842 NS NS 52.58 ENSP00000345973.2:p.Lys28Asn ENST00000344576.6:c.84G>T 7:g.55019361G>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 17218 1423801 1333829 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51785911 COSM48912 104593002 c.1351_1352delinsTT p.R451F Substitution - Missense het 38 7:55160191-55160192 + - Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000345973.2:p.Arg451Phe ENST00000344576.6:c.1351_1352delinsTT 7:g.55160191_55160192delinsTT EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003170-T01-IM5 2719663 2578484 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51841905 COSM6926730 104563558 c.931T>C p.C311R Substitution - Missense het 38 7:55155871-55155871 + - PATHOGENIC .98694 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Cys311Arg ENST00000344576.6:c.931T>C 7:g.55155871T>C EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0003068-T01-IM5 2719577 2578398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51843270 COSM6926023 104574519 c.1088C>A p.T363N Substitution - Missense het 38 7:55156614-55156614 + - PATHOGENIC .99429 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Thr363Asn ENST00000344576.6:c.1088C>A 7:g.55156614C>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 P-0012194-T01-IM5 2727317 2586138 skin NS NS NS malignant_melanoma NS NS NS n COSV51860991 COSM6983544 104566326 c.97_98delinsAA p.G33N Substitution - Missense het 38 7:55142294-55142295 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000345973.2:p.Gly33Asn ENST00000344576.6:c.97_98delinsAA 7:g.55142294_55142295delinsAA EGFR_ENST00000344576 ENST00000344576.6 2118 3236 GB052T 2634017 2494413 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 104561826 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 672 NS primary ENSP00000345973.2:p.Arg222Cys ENST00000344576.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-A7-A6VX-01 2262909 2129893 breast NS NS NS carcinoma NS NS NS y COSV99294439 COSM7672524 104573784 c.439G>A p.A147T Substitution - Missense 38 7:55146620-55146620 + - PATHOGENIC .9897 Confirmed somatic variant 414 NS primary 68 ENSP00000345973.2:p.Ala147Thr ENST00000344576.6:c.439G>A 7:g.55146620G>A EGFR_ENST00000344576 ENST00000344576.6 2118 3236 TCGA-4W-AA9T-01 2339571 2204554 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 104563808 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS primary 54 ENSP00000345973.2:p.Ala289Val ENST00000344576.6:c.866C>T 7:g.55154129C>T WNT9A ENST00000272164.5 1098 12778 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV99688173 COSM8546090 97135478 c.674C>T p.T225M Substitution - Missense 38 1:227921942-227921942 - - PATHOGENIC .99327 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000272164.5:p.Thr225Met ENST00000272164.5:c.674C>T 1:g.227921942G>A KIFC3_ENST00000562903 ENST00000562903.5 2064 6326 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65551650 COSM971903 160336088 c.277C>T p.R93W Substitution - Missense 38 16:57771269-57771269 - - PATHOGENIC .87712 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000456239.1:p.Arg93Trp ENST00000562903.5:c.277C>T 16:g.57771269G>A LINGO1_ENST00000561030 ENST00000561030.5 1845 21205 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV100796453 COSM8304855 160840276 c.1618G>A p.A540T Substitution - Missense 38 15:77614271-77614271 - - PATHOGENIC .96149 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000453853.1:p.Ala540Thr ENST00000561030.5:c.1618G>A 15:g.77614271C>T FBXO43 ENST00000428847.2 2127 28521 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105938795 COSM10012969 125291144 c.49G>A p.V17I Substitution - Missense 38 8:100145087-100145087 - - NEUTRAL .01079 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000403293.2:p.Val17Ile ENST00000428847.2:c.49G>A 8:g.100145087C>T RBL2 ENST00000262133.10 3420 9894 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105858198 COSM10012769 100215732 c.329A>T p.N110I Substitution - Missense 38 16:53439104-53439104 + - PATHOGENIC .99225 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000262133.6:p.Asn110Ile ENST00000262133.10:c.329A>T 16:g.53439104A>T RYR2 ENST00000366574.6 14904 10484 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105921013 COSM10012917 108086673 c.12438G>C p.E4146D Substitution - Missense 38 1:237784150-237784150 + - PATHOGENIC .92502 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000355533.2:p.Glu4146Asp ENST00000366574.6:c.12438G>C 1:g.237784150G>C MTCL1_ENST00000306329 ENST00000306329.15 5718 29121 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV60406354 COSM5665008 104521975 c.2161G>A p.A721T Substitution - Missense 38 18:8784193-8784193 + - PATHOGENIC .91329 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000305027.11:p.Ala721Thr ENST00000306329.15:c.2161G>A 18:g.8784193G>A KIAA1328_ENST00000591619 ENST00000591619.5 1722 29248 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV54469129 COSM2811627 164401538 c.1643C>T p.T548I Substitution - Missense 38 18:37222148-37222148 + - NEUTRAL .10669 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000465550.1:p.Thr548Ile ENST00000591619.5:c.1643C>T 18:g.37222148C>T ITPKB ENST00000429204.5 2841 6179 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV99684689 COSM8532039 126106677 c.977C>T p.P326L Substitution - Missense 38 1:226736482-226736482 - - NEUTRAL .01729 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000411152.1:p.Pro326Leu ENST00000429204.5:c.977C>T 1:g.226736482G>A HTR3E_ENST00000415389 ENST00000415389.6 1371 24005 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105899663 COSM10012911 123252200 c.508C>A p.P170T Substitution - Missense 38 3:184104905-184104905 + - PATHOGENIC .98714 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000401444.2:p.Pro170Thr ENST00000415389.6:c.508C>A 3:g.184104905C>A OR10K1_ENST00000641535 ENST00000641535.1 942 14693 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV56872727 COSM5698964 174042857 c.346G>T p.A116S Substitution - Missense 38 1:158465907-158465907 + - .50134 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000493025.1:p.Ala116Ser ENST00000641535.1:c.346G>T 1:g.158465907G>T HMGB1_ENST00000339872 ENST00000339872.8 648 4983 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV58104601 COSM3813701 105277633 c.630A>T p.E210D Substitution - Missense 38 13:30461375-30461375 - - .57857 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000343040.4:p.Glu210Asp ENST00000339872.8:c.630A>T 13:g.30461375T>A CEACAM20_ENST00000614577 ENST00000614577.4 1512 24879 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105885448 COSM10012840 169253773 c.211T>C p.S71P Substitution - Missense 38 19:44524247-44524247 - - NEUTRAL .07541 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000482943.1:p.Ser71Pro ENST00000614577.4:c.211T>C 19:g.44524247A>G CEACAM20_ENST00000611497 ENST00000611497.4 1755 24879 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105885448 COSM10012840 167066712 c.211T>C p.S71P Substitution - Missense 38 19:44524247-44524247 - - NEUTRAL .07541 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000483912.1:p.Ser71Pro ENST00000611497.4:c.211T>C 19:g.44524247A>G WSCD1 ENST00000574946.5 1728 29060 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV58497674 COSM4749261 162881519 c.695G>A p.R232H Substitution - Missense 38 17:6090473-6090473 + - PATHOGENIC .71202 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000460825.1:p.Arg232His ENST00000574946.5:c.695G>A 17:g.6090473G>A TRMT10B ENST00000297994.3 951 26454 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105877142 COSM10012898 98744531 c.602G>C p.S201T Substitution - Missense 38 9:37769969-37769969 + - .6772 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000297994.3:p.Ser201Thr ENST00000297994.3:c.602G>C 9:g.37769969G>C CDC27 ENST00000531206.5 2493 1728 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV50397621 COSM472929 152915319 c.601G>A p.V201I Substitution - Missense 38 17:47157259-47157259 - - PATHOGENIC .97866 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000434614.1:p.Val201Ile ENST00000531206.5:c.601G>A 17:g.47157259C>T BRSK1 ENST00000309383.5 2337 18994 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105897071 COSM10012785 102342815 c.436T>A p.F146I Substitution - Missense 38 19:55289598-55289598 + - PATHOGENIC .95752 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000310649.1:p.Phe146Ile ENST00000309383.5:c.436T>A 19:g.55289598T>A EVA1C_ENST00000382699 ENST00000382699.7 1317 13239 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105891752 COSM10012968 117582241 c.871G>A p.G291R Substitution - Missense 38 21:32503946-32503946 + - NEUTRAL .06179 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000372146.3:p.Gly291Arg ENST00000382699.7:c.871G>A 21:g.32503946G>A SLC4A4_ENST00000340595 ENST00000340595.3 3108 11030 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV52623703 COSM420534 106302598 c.2176G>A p.V726I Substitution - Missense 38 4:71534254-71534254 + - PATHOGENIC .91286 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000344272.3:p.Val726Ile ENST00000340595.3:c.2176G>A 4:g.71534254G>A HNRNPCL1 ENST00000317869.6 882 29295 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105892039 COSM10012803 105849276 c.218G>T p.R73I Substitution - Missense 38 1:12848072-12848072 - - .65423 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000365370.3:p.Arg73Ile ENST00000317869.6:c.218G>T 1:g.12848072C>A KIFC3_ENST00000543930 ENST00000543930.5 2055 6326 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65551650 COSM971903 154752015 c.277C>T p.R93W Substitution - Missense 38 16:57771269-57771269 - - PATHOGENIC .87712 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000444012.1:p.Arg93Trp ENST00000543930.5:c.277C>T 16:g.57771269G>A SEZ6 ENST00000317338.16 2985 15955 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105887926 COSM10012920 105325861 c.1904T>C p.I635T Substitution - Missense 38 17:28959340-28959340 - - PATHOGENIC .9935 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000312942.11:p.Ile635Thr ENST00000317338.16:c.1904T>C 17:g.28959340A>G KIAA1549_ENST00000440172 ENST00000440172.5 5805 22219 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105841100 COSM10012915 129263440 c.2213C>T p.T738M Substitution - Missense 38 7:138917413-138917413 - - NEUTRAL .05255 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000406661.1:p.Thr738Met ENST00000440172.5:c.2213C>T 7:g.138917413G>A GFOD1_ENST00000612338 ENST00000612338.4 864 21096 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV64954773 COSM6670542 168666563 c.811G>A p.A271T Substitution - Missense 38 6:13364796-13364796 - - PATHOGENIC .98237 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000479493.1:p.Ala271Thr ENST00000612338.4:c.811G>A 6:g.13364796C>T WSCD1_ENST00000574232 ENST00000574232.5 1728 29060 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV58497674 COSM4749261 161804024 c.695G>A p.R232H Substitution - Missense 38 17:6090473-6090473 + - PATHOGENIC .71202 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000458374.1:p.Arg232His ENST00000574232.5:c.695G>A 17:g.6090473G>A FER1L6 ENST00000522917.5 5574 28065 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105936848 COSM10012853 146914186 c.4500G>T p.Q1500H Substitution - Missense 38 8:124091531-124091531 + - PATHOGENIC .88093 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000428280.1:p.Gln1500His ENST00000522917.5:c.4500G>T 8:g.124091531G>T KIAA0100 ENST00000528896.6 6708 28960 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV101197296 COSM8902986 149527505 c.3170G>A p.R1057H Substitution - Missense 38 17:28633987-28633987 - - PATHOGENIC .83007 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000436773.2:p.Arg1057His ENST00000528896.6:c.3170G>A 17:g.28633987C>T GLIPR2_ENST00000377959 ENST00000377959.5 387 18007 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105927447 COSM10012961 116308603 c.73G>A p.G25S Substitution - Missense 38 9:36147845-36147845 + - .67561 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000367195.1:p.Gly25Ser ENST00000377959.5:c.73G>A 9:g.36147845G>A NOX5_ENST00000448182 ENST00000448182.7 2160 14874 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105871370 COSM10012832 131157340 c.1049A>T p.E350V Substitution - Missense 38 15:69035935-69035935 + - PATHOGENIC .81287 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000410887.3:p.Glu350Val ENST00000448182.7:c.1049A>T 15:g.69035935A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2862107 2862107 2717309 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV105111081 COSM9572577 106244184 c.1453G>A p.G485S Substitution - Missense 38 7:55160293-55160293 + - NEUTRAL .00282 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000342376.3:p.Gly485Ser ENST00000342916.7:c.1453G>A 7:g.55160293G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2840810 2840810 2696370 prostate NS NS NS carcinoma NS NS NS n COSV104577207 COSM9493802 106271013 c.686G>A p.S229N Substitution - Missense 38 7:55152603-55152603 + - PATHOGENIC .9474 Variant of unknown origin 31874108 surgery-fixed metastasis ENSP00000342376.3:p.Ser229Asn ENST00000342916.7:c.686G>A 7:g.55152603G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 5-GE067-T1 2869773 2724770 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51802062 COSM6008937 106244360 c.659C>T p.S220F Substitution - Missense 38 7:55152576-55152576 + - PATHOGENIC .98424 Variant of unknown origin 26950094 surgery - NOS NS ENSP00000342376.3:p.Ser220Phe ENST00000342916.7:c.659C>T 7:g.55152576C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194724 1194724 1106619 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849762 COSM29340 106269839 c.818C>A p.T273N Substitution - Missense 38 7:55154081-55154081 + - PATHOGENIC .90357 Variant of unknown origin 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Thr273Asn ENST00000342916.7:c.818C>A 7:g.55154081C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0000030-T01-IM3 2714482 2573303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51789972 COSM6985979 106247910 c.903_906delinsACAC p.T302H Substitution - Missense het 38 7:55155843-55155846 + - Variant of unknown origin 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Thr302His ENST00000342916.7:c.903_906delinsACAC 7:g.55155843_55155846delinsACAC EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-24-1850-01 1731201 1637167 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51792742 COSM1330578 106269199 c.783G>T p.K261N Substitution - Missense het 38 7:55154046-55154046 + - PATHOGENIC .96256 Variant of unknown origin 331 NS primary 72 ENSP00000342376.3:p.Lys261Asn ENST00000342916.7:c.783G>T 7:g.55154046G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 LC20 2439238 2302079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51781350 COSM5369838 106250466 c.407C>G p.P136R Substitution - Missense 38 7:55143471-55143471 + - PATHOGENIC .90708 Variant of unknown origin 26164066 surgery-fixed metastasis ENSP00000342376.3:p.Pro136Arg ENST00000342916.7:c.407C>G 7:g.55143471C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 UCHRP3 2682242 2541515 large_intestine NS NS NS other ulcerative_colitis dysplasia NS n COSV51844380 COSM6854567 106249554 c.856A>G p.S286G Substitution - Missense 38 7:55154119-55154119 + - PATHOGENIC .99273 Variant of unknown origin 28524162 surgery fresh/frozen NS 54 ENSP00000342376.3:p.Ser286Gly ENST00000342916.7:c.856A>G 7:g.55154119A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 UCHRP3 2682242 2541515 large_intestine NS NS NS other ulcerative_colitis dysplasia NS n COSV51844399 COSM6854571 106249560 c.1809C>A p.N603K Substitution - Missense 38 7:55165366-55165366 + - PATHOGENIC .87723 Variant of unknown origin 28524162 surgery fresh/frozen NS 54 ENSP00000342376.3:p.Asn603Lys ENST00000342916.7:c.1809C>A 7:g.55165366C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2862120 2862120 2717322 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV105110976 COSM9572578 106244191 c.1631G>A p.G544D Substitution - Missense 38 7:55161631-55161631 + - PATHOGENIC .99386 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000342376.3:p.Gly544Asp ENST00000342916.7:c.1631G>A 7:g.55161631G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 SUPT1 1760532 1665135 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51819830 COSM327147 106245611 c.752G>A p.C251Y Substitution - Missense 38 7:55154015-55154015 + - PATHOGENIC .98182 Variant of unknown origin 22675565 cell-line NS ENSP00000342376.3:p.Cys251Tyr ENST00000342916.7:c.752G>A 7:g.55154015G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-55-7570-01 1914018 1802300 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51813309 COSM6178064 106266546 c.898G>A p.V300M Substitution - Missense 38 7:55155838-55155838 + - PATHOGENIC .97875 Variant of unknown origin 417 fresh/frozen - NOS primary 60 ENSP00000342376.3:p.Val300Met ENST00000342916.7:c.898G>A 7:g.55155838G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194739 1194739 1106634 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51818096 COSM29341 106255281 c.1860C>G p.C620W Substitution - Missense 38 7:55165417-55165417 + - PATHOGENIC .989 Variant of unknown origin 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Cys620Trp ENST00000342916.7:c.1860C>G 7:g.55165417C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732915 2732915 2591668 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827181 COSM7002280 106259161 c.574C>G p.P192A Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .86378 Variant of unknown origin 28855349 surgery - NOS recurrent 58 ENSP00000342376.3:p.Pro192Ala ENST00000342916.7:c.574C>G 7:g.55151308C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-08-0349-01 1910225 1798516 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51830791 COSM43068 106269508 c.977G>A p.C326Y Substitution - Missense het 38 7:55155917-55155917 + - PATHOGENIC .99356 Variant of unknown origin 329 fresh/frozen - NOS primary 46 ENSP00000342376.3:p.Cys326Tyr ENST00000342916.7:c.977G>A 7:g.55155917G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 LUAD_E01166 1765174 1669494 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51795467 COSM390866 106248181 c.709_710delinsTA p.A237Y Substitution - Missense 38 7:55152626-55152627 + - Variant of unknown origin 22980975 surgery - NOS primary ENSP00000342376.3:p.Ala237Tyr ENST00000342916.7:c.709_710delinsTA 7:g.55152626_55152627delinsTA EGFR_ENST00000342916 ENST00000342916.7 1887 3236 5-GE049-T1 2869762 2724759 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110412 COSM9799019 106270989 c.583C>T p.P195S Substitution - Missense 38 7:55151317-55151317 + - NEUTRAL .41768 Variant of unknown origin 26950094 surgery - NOS NS 80 ENSP00000342376.3:p.Pro195Ser ENST00000342916.7:c.583C>T 7:g.55151317C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2841222 2841222 2696782 prostate NS NS NS carcinoma NS NS NS n COSV104577073 COSM9497234 106267860 c.434A>G p.H145R Substitution - Missense 38 7:55146615-55146615 + - NEUTRAL .16662 Variant of unknown origin 31874108 surgery-fixed primary ENSP00000342376.3:p.His145Arg ENST00000342916.7:c.434A>G 7:g.55146615A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2857410 2857410 2712710 skin NS NS NS malignant_melanoma NS NS NS n COSV51767869 COSM3266583 106241103 c.1351C>T p.R451C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 31980996 surgery-fixed NS ENSP00000342376.3:p.Arg451Cys ENST00000342916.7:c.1351C>T 7:g.55160191C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 LUAD-NYU408 1765248 1669568 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51855104 COSM374570 106244603 c.1721G>T p.R574L Substitution - Missense 38 7:55163822-55163822 + - PATHOGENIC .93703 Variant of unknown origin 22980975 surgery - NOS primary 71 ENSP00000342376.3:p.Arg574Leu ENST00000342916.7:c.1721G>T 7:g.55163822G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 AC-V16-Tumor-SM-9J46H 2584492 2445656 large_intestine anus NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51811313 COSM6008958 106240839 c.745C>G p.L249V Substitution - Missense 38 7:55152662-55152662 + - PATHOGENIC .95619 Variant of unknown origin 27852700 surgery-fixed recurrent ENSP00000342376.3:p.Leu249Val ENST00000342916.7:c.745C>G 7:g.55152662C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PD42092a 2894833 2749321 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV105110933 COSM9881280 106258008 c.1574C>T p.S525F Substitution - Missense 38 7:55161574-55161574 + - PATHOGENIC .96213 Variant of unknown origin 33024263 surgery-fixed metastasis 75 ENSP00000342376.3:p.Ser525Phe ENST00000342916.7:c.1574C>T 7:g.55161574C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 LIM1215_R1_Cetux 2841367 2696923 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576981 COSM9396333 106264247 c.1473A>G p.I491M Substitution - Missense 38 7:55160313-55160313 + - NEUTRAL .12443 Variant of unknown origin 25623215 cell-line NS ENSP00000342376.3:p.Ile491Met ENST00000342916.7:c.1473A>G 7:g.55160313A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MBC032T 2807217 2663921 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99296355 COSM9120806 106266351 c.1655A>C p.N552T Substitution - Missense 38 7:55163756-55163756 + - PATHOGENIC .99524 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000342376.3:p.Asn552Thr ENST00000342916.7:c.1655A>C 7:g.55163756A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2626134 2626134 2486546 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51791433 COSM6191492 106265740 c.887_888delinsTT p.P296L Substitution - Missense 38 7:55154150-55154151 + - Variant of unknown origin 26645239 surgery-fixed NS ENSP00000342376.3:p.Pro296Leu ENST00000342916.7:c.887_888delinsTT 7:g.55154150_55154151delinsTT EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-02-0116-01 1910165 1798456 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51795519 COSM35822 106269735 c.1789G>C p.A597P Substitution - Missense hom 38 7:55165346-55165346 + - NEUTRAL .2004 Variant of unknown origin 329 fresh/frozen - NOS primary 54 ENSP00000342376.3:p.Ala597Pro ENST00000342916.7:c.1789G>C 7:g.55165346G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 VOA1947 2897843 2752142 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105864361 COSM9970409 106261978 c.970C>T p.R324C Substitution - Missense 38 7:55155910-55155910 + - PATHOGENIC .91299 Variant of unknown origin 31477716 surgery-fixed metastasis 69 ENSP00000342376.3:p.Arg324Cys ENST00000342916.7:c.970C>T 7:g.55155910C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-08-0246-01 1910219 1798510 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51792876 COSM43066 106241943 c.767A>C p.D256A Substitution - Missense hom 38 7:55154030-55154030 + - PATHOGENIC .98125 Variant of unknown origin 329 fresh/frozen - NOS primary 57 ENSP00000342376.3:p.Asp256Ala ENST00000342916.7:c.767A>C 7:g.55154030A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-78-7147-01 1914054 1802336 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51797369 COSM6178060 106260864 c.1159C>A p.L387M Substitution - Missense 38 7:55156784-55156784 + - PATHOGENIC .85999 Variant of unknown origin 417 fresh/frozen - NOS primary 67 ENSP00000342376.3:p.Leu387Met ENST00000342916.7:c.1159C>A 7:g.55156784C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NAN8 2809783 2666453 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV99289304 COSM9153919 106251574 c.670C>T p.R224C Substitution - Missense het 38 7:55152587-55152587 + - PATHOGENIC .90413 Variant of unknown origin 30545397 cell-line primary ENSP00000342376.3:p.Arg224Cys ENST00000342916.7:c.670C>T 7:g.55152587C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MBC531 2807310 2664014 breast NS NS NS carcinoma NS NS NS n COSV99286738 COSM9120811 106269846 c.1219A>G p.I407V Substitution - Missense 38 7:55157674-55157674 + - PATHOGENIC .99284 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000342376.3:p.Ile407Val ENST00000342916.7:c.1219A>G 7:g.55157674A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 AMO1 2809758 2666428 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasmacytoma NS NS y COSV51777457 COSM1236015 106250652 c.627A>C p.K209N Substitution - Missense het 38 7:55151361-55151361 + - NEUTRAL .14933 Variant of unknown origin 30545397 cell-line NS ENSP00000342376.3:p.Lys209Asn ENST00000342916.7:c.627A>C 7:g.55151361A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 H1793 2776325 2634461 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51866889 COSM3266567 106245602 c.932G>T p.C311F Substitution - Missense 38 7:55155872-55155872 + - PATHOGENIC .99418 Variant of unknown origin 29681454 NS NS 52 ENSP00000342376.3:p.Cys311Phe ENST00000342916.7:c.932G>T 7:g.55155872G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 DM16 2466857 2329688 skin head_neck NS NS malignant_melanoma desmoplastic NS NS n COSV51842833 COSM5608338 106258998 c.794C>T p.P265L Substitution - Missense 38 7:55154057-55154057 + - PATHOGENIC .98876 Variant of unknown origin 26343386 surgery-fixed NS 80 ENSP00000342376.3:p.Pro265Leu ENST00000342916.7:c.794C>T 7:g.55154057C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2585427 2585427 2446591 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51767869 COSM3266583 106241103 c.1351C>T p.R451C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 25623215 surgery - NOS recurrent ENSP00000342376.3:p.Arg451Cys ENST00000342916.7:c.1351C>T 7:g.55160191C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 OV207 1716842 1624327 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51806026 COSM252488 106255293 c.493C>T p.R165W Substitution - Missense 38 7:55146674-55146674 + - NEUTRAL .14815 Variant of unknown origin 22102435 surgery fresh/frozen NS ENSP00000342376.3:p.Arg165Trp ENST00000342916.7:c.493C>T 7:g.55146674C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2 2557184 2418609 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51828150 COSM5976431 106241667 c.1555G>A p.E519K Substitution - Missense 38 7:55161555-55161555 + - PATHOGENIC .8557 Variant of unknown origin 26934577 surgery fresh/frozen NS ENSP00000342376.3:p.Glu519Lys ENST00000342916.7:c.1555G>A 7:g.55161555G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 DM10 2466851 2329682 skin face NS NS malignant_melanoma desmoplastic NS NS n COSV51850876 COSM5608334 106246923 c.1357C>T p.L453F Substitution - Missense 38 7:55160197-55160197 + - PATHOGENIC .96542 Variant of unknown origin 26343386 surgery-fixed NS 70 ENSP00000342376.3:p.Leu453Phe ENST00000342916.7:c.1357C>T 7:g.55160197C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 WSU-HN30 2296299 2161902 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51845363 COSM4600429 106242133 c.316A>T p.I106F Substitution - Missense 38 7:55143380-55143380 + - PATHOGENIC .97255 Variant of unknown origin 25275298 cell-line NS ENSP00000342376.3:p.Ile106Phe ENST00000342916.7:c.316A>T 7:g.55143380A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105111181 COSM9542450 106252483 c.61G>A p.A21T Substitution - Missense 38 7:55019338-55019338 + - NEUTRAL .06121 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000342376.3:p.Ala21Thr ENST00000342916.7:c.61G>A 7:g.55019338G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 ESO-721 1890961 1780330 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV51788608 COSM1251016 106247385 c.1340C>A p.S447Y Substitution - Missense 38 7:55160180-55160180 + - .5293 Variant of unknown origin 23525077 surgery fresh/frozen primary 68 ENSP00000342376.3:p.Ser447Tyr ENST00000342916.7:c.1340C>A 7:g.55160180C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00226T00226 2857365 2712665 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 106252501 c.1162G>A p.D388N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000342376.3:p.Asp388Asn ENST00000342916.7:c.1162G>A 7:g.55156787G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 VOA1720 2897846 2752145 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105864482 COSM9969894 106263582 c.494G>C p.R165P Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .25613 Variant of unknown origin 31477716 surgery-fixed NS 73 ENSP00000342376.3:p.Arg165Pro ENST00000342916.7:c.494G>C 7:g.55146675G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-95-7947-01 1914103 1802385 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51819886 COSM6178068 106243936 c.271A>G p.I91V Substitution - Missense 38 7:55143335-55143335 + - PATHOGENIC .98845 Variant of unknown origin 417 fresh/frozen - NOS primary 67 ENSP00000342376.3:p.Ile91Val ENST00000342916.7:c.271A>G 7:g.55143335A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732914 2732914 2591667 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827181 COSM7002280 106259161 c.574C>G p.P192A Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .86378 Variant of unknown origin 28855349 surgery - NOS primary 58 ENSP00000342376.3:p.Pro192Ala ENST00000342916.7:c.574C>G 7:g.55151308C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GBC_6 2907852 2762035 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV105864473 COSM10029109 106263694 c.1360A>G p.K454E Substitution - Missense 38 7:55160200-55160200 + - PATHOGENIC .95086 Variant of unknown origin 33563892 surgery-fixed NS 85 ENSP00000342376.3:p.Lys454Glu ENST00000342916.7:c.1360A>G 7:g.55160200A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 DM51 2466875 2329706 skin neck NS NS malignant_melanoma desmoplastic NS NS n COSV51774157 COSM5608355 106258641 c.1806A>T p.E602D Substitution - Missense 38 7:55165363-55165363 + - PATHOGENIC .71202 Variant of unknown origin 26343386 surgery-fixed NS 88 ENSP00000342376.3:p.Glu602Asp ENST00000342916.7:c.1806A>T 7:g.55165363A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 UVDUD0 2762706 2620965 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51767906 COSM7340119 106264867 c.433C>A p.H145N Substitution - Missense 38 7:55146614-55146614 + - NEUTRAL .01483 Variant of unknown origin 29615459 NS primary 63 ENSP00000342376.3:p.His145Asn ENST00000342916.7:c.433C>A 7:g.55146614C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 BL-18-K10011 2905035 2759291 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864163 COSM10000367 106255324 c.407C>A p.P136H Substitution - Missense 38 7:55143471-55143471 + - PATHOGENIC .91703 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000342376.3:p.Pro136His ENST00000342916.7:c.407C>A 7:g.55143471C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 OX-CO-2_R2_Cetux 2841377 2696927 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576981 COSM9396333 106264247 c.1473A>G p.I491M Substitution - Missense 38 7:55160313-55160313 + - NEUTRAL .12443 Variant of unknown origin 25623215 cell-line NS ENSP00000342376.3:p.Ile491Met ENST00000342916.7:c.1473A>G 7:g.55160313A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 UM-SCC-17B 2296307 2161910 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825836 COSM4599146 106251401 c.345T>A p.N115K Substitution - Missense 38 7:55143409-55143409 + - NEUTRAL .2671 Variant of unknown origin 25275298 cell-line NS 47 ENSP00000342376.3:p.Asn115Lys ENST00000342916.7:c.345T>A 7:g.55143409T>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 106252501 c.1162G>A p.D388N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000342376.3:p.Asp388Asn ENST00000342916.7:c.1162G>A 7:g.55156787G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51841162 COSM1090865 106241797 c.594C>A p.S198R Substitution - Missense het 38 7:55151328-55151328 + - PATHOGENIC .8706 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000342376.3:p.Ser198Arg ENST00000342916.7:c.594C>A 7:g.55151328C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51841184 COSM1090877 106241809 c.1621C>A p.L541I Substitution - Missense het 38 7:55161621-55161621 + - NEUTRAL .01946 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000342376.3:p.Leu541Ile ENST00000342916.7:c.1621C>A 7:g.55161621C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 RDES 2294586 2160613 bone NS NS NS Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour NS NS NS y COSV51793186 COSM4587483 106259063 c.1798A>G p.M600V Substitution - Missense 38 7:55165355-55165355 + - PATHOGENIC .89999 Variant of unknown origin 25186949 cell-line NS ENSP00000342376.3:p.Met600Val ENST00000342916.7:c.1798A>G 7:g.55165355A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2579503 2579503 2440840 NS NS NS NS malignant_melanoma NS NS NS n COSV51849040 COSM6005740 106254452 c.353C>T p.A118V Substitution - Missense 38 7:55143417-55143417 + - PATHOGENIC .99538 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000342376.3:p.Ala118Val ENST00000342916.7:c.353C>T 7:g.55143417C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 KARPAS45 1760525 1665128 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51767338 COSM327145 106245007 c.227T>C p.L76P Substitution - Missense 38 7:55142424-55142424 + - PATHOGENIC .97399 Variant of unknown origin 22675565 cell-line NS ENSP00000342376.3:p.Leu76Pro ENST00000342916.7:c.227T>C 7:g.55142424T>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-273-tumor 2819121 2675420 meninges NS NS NS meningioma anaplastic NS NS n COSV104369217 COSM9267459 106254545 c.1414G>A p.A472T Substitution - Missense 38 7:55160254-55160254 + - PATHOGENIC .94147 Variant of unknown origin 28713588 surgery - NOS NS ENSP00000342376.3:p.Ala472Thr ENST00000342916.7:c.1414G>A 7:g.55160254G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 AMO1 1889514 1778954 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV51777457 COSM1236015 106250652 c.627A>C p.K209N Substitution - Missense 38 7:55151361-55151361 + - NEUTRAL .14933 Variant of unknown origin 23396385 cell-line NS ENSP00000342376.3:p.Lys209Asn ENST00000342916.7:c.627A>C 7:g.55151361A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00243T00243 2857340 2712640 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105111181 COSM9542450 106252483 c.61G>A p.A21T Substitution - Missense 38 7:55019338-55019338 + - NEUTRAL .06121 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000342376.3:p.Ala21Thr ENST00000342916.7:c.61G>A 7:g.55019338G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TMIT_I_12 2765652 2623896 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV99034441 COSM7346604 106243183 c.1123G>A p.A375T Substitution - Missense 38 7:55156649-55156649 + - PATHOGENIC .97686 Variant of unknown origin 30239046 surgery-fixed NS ENSP00000342376.3:p.Ala375Thr ENST00000342916.7:c.1123G>A 7:g.55156649G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 DM17 2466858 2329689 skin arm NS NS malignant_melanoma desmoplastic NS NS n COSV51804378 COSM5608346 106262227 c.1558C>T p.P520S Substitution - Missense 38 7:55161558-55161558 + - PATHOGENIC .7492 Variant of unknown origin 26343386 surgery-fixed NS 74 ENSP00000342376.3:p.Pro520Ser ENST00000342916.7:c.1558C>T 7:g.55161558C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2626094 2626094 2486506 lung NS NS NS carcinoid-endocrine_tumour atypical NS NS n COSV51823853 COSM6191491 106239222 c.311T>A p.L104Q Substitution - Missense hom 38 7:55143375-55143375 + - PATHOGENIC .99116 Variant of unknown origin 26645239 surgery-fixed NS ENSP00000342376.3:p.Leu104Gln ENST00000342916.7:c.311T>A 7:g.55143375T>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 DM26 2466862 2329693 skin scalp NS NS malignant_melanoma desmoplastic NS NS n COSV51820811 COSM5611257 106261646 c.1788_1789delinsAA p.A597T Substitution - Missense 38 7:55165345-55165346 + - Variant of unknown origin 26343386 surgery-fixed NS 79 ENSP00000342376.3:p.Ala597Thr ENST00000342916.7:c.1788_1789delinsAA 7:g.55165345_55165346delinsAA EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732917 2732917 2591670 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827197 COSM7002281 106257939 c.1784G>A p.C595Y Substitution - Missense 38 7:55165341-55165341 + - PATHOGENIC .99683 Variant of unknown origin 28855349 surgery - NOS primary 39 ENSP00000342376.3:p.Cys595Tyr ENST00000342916.7:c.1784G>A 7:g.55165341G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00389T00389 2857373 2712673 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 106252501 c.1162G>A p.D388N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000342376.3:p.Asp388Asn ENST00000342916.7:c.1162G>A 7:g.55156787G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-144-tumor 2819049 2675348 meninges NS NS NS meningioma atypical NS NS n COSV104369075 COSM9267309 106250938 c.1816C>G p.L606V Substitution - Missense 38 7:55165373-55165373 + - PATHOGENIC .90295 Variant of unknown origin 28713588 surgery - NOS NS ENSP00000342376.3:p.Leu606Val ENST00000342916.7:c.1816C>G 7:g.55165373C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 LPS3 2800446 2657262 soft_tissue fat NS NS liposarcoma well_differentiated NS NS n COSV99289299 COSM9110946 106255980 c.1249C>T p.L417F Substitution - Missense 38 7:55157704-55157704 + - PATHOGENIC .98762 Variant of unknown origin 26643872 surgery - NOS primary ENSP00000342376.3:p.Leu417Phe ENST00000342916.7:c.1249C>T 7:g.55157704C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 K5B66H 2762307 2620566 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51767869 COSM3266583 106241103 c.1351C>T p.R451C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 29615459 NS primary 42 ENSP00000342376.3:p.Arg451Cys ENST00000342916.7:c.1351C>T 7:g.55160191C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-176-tumor 2819069 2675368 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732608 2732608 2591361 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779091 COSM2155593 106245463 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Reported in another cancer sample as somatic 26757882 surgery-fixed primary 57 ENSP00000342376.3:p.Thr363Ile ENST00000342916.7:c.1088C>T 7:g.55156614C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CCK-81_R1_Cetux 2841357 2696917 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 106246290 c.1391C>T p.S464L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000342376.3:p.Ser464Leu ENST00000342916.7:c.1391C>T 7:g.55160231C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2579438 2579438 2440775 NS NS NS NS malignant_melanoma NS NS NS n COSV51781415 COSM6005739 106256408 c.326G>A p.G109E Substitution - Missense 38 7:55143390-55143390 + - PATHOGENIC .99562 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000342376.3:p.Gly109Glu ENST00000342916.7:c.326G>A 7:g.55143390G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1047 2491942 2354571 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour borderline NS n COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 26437033 surgery fresh/frozen NS 63 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00196T00196 2857366 2712666 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 BL-17-E51214 2905659 2759915 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864645 COSM9997785 106268823 c.1721G>A p.R574Q Substitution - Missense 38 7:55163822-55163822 + - PATHOGENIC .88204 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000342376.3:p.Arg574Gln ENST00000342916.7:c.1721G>A 7:g.55163822G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 EGCT1088 2490716 2353365 testis NS NS NS germ_cell_tumour choriocarcinoma NS NS n COSV51835294 COSM5749118 106255759 c.1723G>A p.G575R Substitution - Missense 38 7:55165280-55165280 + - PATHOGENIC .99792 Variant of unknown origin 26956871 surgery fresh/frozen primary ENSP00000342376.3:p.Gly575Arg ENST00000342916.7:c.1723G>A 7:g.55165280G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2579678 2579678 2441015 NS NS NS NS malignant_melanoma NS NS NS n COSV51769129 COSM6005742 106249248 c.1801_1802delinsAA p.G601K Substitution - Missense 38 7:55165358-55165359 + - Variant of unknown origin 25148578 surgery-fixed NS ENSP00000342376.3:p.Gly601Lys ENST00000342916.7:c.1801_1802delinsAA 7:g.55165358_55165359delinsAA EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732913 2732913 2591666 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 106240722 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 60 ENSP00000342376.3:p.Ala289Asp ENST00000342916.7:c.866C>A 7:g.55154129C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-264-tumor 2819115 2675414 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 AC-V10-Tumor-SM-9J465 2584480 2445644 large_intestine anus NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51802062 COSM6008937 106244360 c.659C>T p.S220F Substitution - Missense 38 7:55152576-55152576 + - PATHOGENIC .98424 Variant of unknown origin 27852700 surgery-fixed primary ENSP00000342376.3:p.Ser220Phe ENST00000342916.7:c.659C>T 7:g.55152576C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2509044 2509044 2371379 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 49 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-061-tumor 2819000 2675299 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2808101 2808101 2664786 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 31258848 surgery-fixed NS 60 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00229T00229 2857347 2712647 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MBC067T 2807243 2663947 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99294040 COSM9120802 106247209 c.379G>A p.A127T Substitution - Missense 38 7:55143443-55143443 + - NEUTRAL .01752 Reported in another cancer sample as somatic 31340200 surgery - NOS NS ENSP00000342376.3:p.Ala127Thr ENST00000342916.7:c.379G>A 7:g.55143443G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-02-0023-01 1910131 1798422 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 38 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-081-tumor 2819015 2675314 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-78-7155-01 1914061 1802343 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51802828 COSM6178056 106269754 c.1296A>T p.Q432H Substitution - Missense 38 7:55157751-55157751 + - PATHOGENIC .9647 Variant of unknown origin 417 fresh/frozen - NOS primary 68 ENSP00000342376.3:p.Gln432His ENST00000342916.7:c.1296A>T 7:g.55157751A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-116-tumor 2819038 2675337 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 SA-N101 2521507 2383850 central_nervous_system spinal_cord NS NS glioma astrocytoma_Grade_II fibrillary NS n COSV51785554 COSM21688 106239985 c.971G>T p.R324L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Reported in another cancer sample as somatic 26487540 surgery-fixed NS 82 ENSP00000342376.3:p.Arg324Leu ENST00000342916.7:c.971G>T 7:g.55155911G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 BL-17-W08054 2905635 2759891 urinary_tract NS NS NS carcinoma transitional_cell_carcinoma NS NS n COSV105863907 COSM9995468 106248614 c.1724G>A p.G575E Substitution - Missense 38 7:55165281-55165281 + - PATHOGENIC .99217 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000342376.3:p.Gly575Glu ENST00000342916.7:c.1724G>A 7:g.55165281G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-05-4410-01 1780064 1684063 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51823181 COSM6110421 106255575 c.1131G>T p.R377S Substitution - Missense 38 7:55156657-55156657 + - NEUTRAL .42615 Variant of unknown origin 417 fresh/frozen - NOS primary 62 ENSP00000342376.3:p.Arg377Ser ENST00000342916.7:c.1131G>T 7:g.55156657G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0002PT00040T00040 2857344 2712644 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-209-tumor 2819091 2675390 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-194-tumor 2819079 2675378 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-38-4629-01 1780093 1684092 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51776247 COSM6110417 106247348 c.1393G>A p.G465R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 68 ENSP00000342376.3:p.Gly465Arg ENST00000342916.7:c.1393G>A 7:g.55160233G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-270-tumor 2819119 2675418 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-08-0390-01 1910243 1798534 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 69 ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-08-0390-01 1910243 1798534 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51822289 COSM42977 106250610 c.315G>T p.Q105H Substitution - Missense het 38 7:55143379-55143379 + - PATHOGENIC .90579 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 69 ENSP00000342376.3:p.Gln105His ENST00000342916.7:c.315G>T 7:g.55143379G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 BL-18-T40375 2905680 2759936 NS NS NS NS malignant_melanoma NS NS NS n COSV105864576 COSM9994315 106265642 c.1535C>T p.P512L Substitution - Missense 38 7:55161535-55161535 + - NEUTRAL .20165 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000342376.3:p.Pro512Leu ENST00000342916.7:c.1535C>T 7:g.55161535C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2696526 2696526 2555430 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 28201779 surgery fresh/frozen NS 72 ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-089-tumor 2819020 2675319 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 LIM1215_R5_Cetux 2841371 2696923 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51776247 COSM6110417 106247348 c.1393G>A p.G465R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000342376.3:p.Gly465Arg ENST00000342916.7:c.1393G>A 7:g.55160233G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-189-tumor 2819075 2675374 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2509057 2509057 2371392 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51783296 COSM5878511 106259042 c.661G>T p.G221W Substitution - Missense 38 7:55152578-55152578 + - NEUTRAL .4823 Variant of unknown origin 26919320 surgery - NOS NS 43 ENSP00000342376.3:p.Gly221Trp ENST00000342916.7:c.661G>T 7:g.55152578G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S001097 1027690 944666 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 106240722 c.866C>A p.A289D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Ala289Asp ENST00000342916.7:c.866C>A 7:g.55154129C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-12-0616-01 1910246 1798537 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 36 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51803429 COSM7002279 106244158 c.1280G>A p.R427H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000342376.3:p.Arg427His ENST00000342916.7:c.1280G>A 7:g.55157735G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-246-tumor 2819109 2675408 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-073-tumor 2819009 2675308 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00005T00005 2857374 2712674 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-043-tumor 2818993 2675292 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00329T00329 2857335 2712635 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2819307 2819307 2675606 lung left_upper_lobe NS NS carcinoma invasive_mucinous_adenocarcinoma NS NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 30572543 circulating tumour NS 80 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 109600 2812903 2669317 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 46 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-150-tumor 2819055 2675354 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00300T00300 2857355 2712655 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00296T00296 2857351 2712651 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732920 2732920 2591673 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 106241473 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 73 ENSP00000342376.3:p.Thr263Pro ENST00000342916.7:c.787A>C 7:g.55154050A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00177T00177 2857368 2712668 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00204T00204 2857356 2712656 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2509042 2509042 2371377 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 106241473 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 74 ENSP00000342376.3:p.Thr263Pro ENST00000342916.7:c.787A>C 7:g.55154050A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 9VWJAP 2762757 2621016 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51826193 COSM7340403 106247331 c.458A>G p.N153S Substitution - Missense 38 7:55146639-55146639 + - PATHOGENIC .99355 Reported in another cancer sample as somatic 29615459 NS NS 71 ENSP00000342376.3:p.Asn153Ser ENST00000342916.7:c.458A>G 7:g.55146639A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-103-tumor 2819029 2675328 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732919 2732919 2591672 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 106241473 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 73 ENSP00000342376.3:p.Thr263Pro ENST00000342916.7:c.787A>C 7:g.55154050A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194729 1194729 1106624 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-099-tumor 2819026 2675325 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-205-tumor 2819087 2675386 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0127-01 1910170 1798461 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766389 COSM43067 106251527 c.874G>T p.V292L Substitution - Missense het 38 7:55154137-55154137 + - PATHOGENIC .98997 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 67 ENSP00000342376.3:p.Val292Leu ENST00000342916.7:c.874G>T 7:g.55154137G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-042-tumor 2818992 2675291 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-160-tumor 2819059 2675358 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00331T00331 2857371 2712671 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-104-tumor 2819030 2675329 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732886 2732886 2591639 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779091 COSM2155593 106245463 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 50 ENSP00000342376.3:p.Thr363Ile ENST00000342916.7:c.1088C>T 7:g.55156614C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-228-tumor 2819103 2675402 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-076-tumor 2819012 2675311 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 109588 2812897 2669311 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 45 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00221T00221 2857376 2712676 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 109618 2812909 2669323 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 52 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-125-tumor 2819044 2675343 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-027-tumor 2818987 2675286 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0002PT00013T00013 2857370 2712670 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 BL-16-G30012 2905599 2759855 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51815598 COSM6471954 106247618 c.1325G>T p.S442I Substitution - Missense 38 7:55160165-55160165 + - NEUTRAL .44157 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000342376.3:p.Ser442Ile ENST00000342916.7:c.1325G>T 7:g.55160165G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00332T00332 2857343 2712643 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0002PT00039T00039 2857325 2712625 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-266-tumor 2819117 2675416 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 SJHYPO052 2301072 2166353 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 106242402 c.1279C>T p.R427C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Reported in another cancer sample as somatic 638 NS NS ENSP00000342376.3:p.Arg427Cys ENST00000342916.7:c.1279C>T 7:g.55157734C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0157-01 1910184 1798475 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 63 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-112-tumor 2819035 2675334 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2855910 2855910 2711313 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV104368998 COSM9232920 106247232 c.886C>T p.P296S Substitution - Missense 38 7:55154149-55154149 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 32269842 surgery-fixed NS 58 ENSP00000342376.3:p.Pro296Ser ENST00000342916.7:c.886C>T 7:g.55154149C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00354T00354 2857354 2712654 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0002PT00013T00013 2857370 2712670 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV99291226 COSM7552389 106251847 c.1124C>T p.A375V Substitution - Missense 38 7:55156650-55156650 + - PATHOGENIC .98971 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Ala375Val ENST00000342916.7:c.1124C>T 7:g.55156650C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-02-0003-01 1910122 1798413 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51809225 COSM35825 106252732 c.1859G>A p.C620Y Substitution - Missense het 38 7:55165416-55165416 + - PATHOGENIC .99893 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 50 ENSP00000342376.3:p.Cys620Tyr ENST00000342916.7:c.1859G>A 7:g.55165416G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-147-tumor 2819052 2675351 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51803429 COSM7002279 106244158 c.1280G>A p.R427H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000342376.3:p.Arg427His ENST00000342916.7:c.1280G>A 7:g.55157735G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00320T00320 2857338 2712638 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-273-tumor 2819121 2675420 meninges NS NS NS meningioma anaplastic NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 109590 2812898 2669312 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 56 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-AP-A051-01 1783330 1687329 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51848796 COSM1090874 106245640 c.1321G>A p.V441I Substitution - Missense het 38 7:55160161-55160161 + - PATHOGENIC .92435 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000342376.3:p.Val441Ile ENST00000342916.7:c.1321G>A 7:g.55160161G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732921 2732921 2591674 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 49 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2878966 2878966 2733481 oesophagus NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51813913 COSM6023901 106243021 c.344A>C p.N115T Substitution - Missense 38 7:55143408-55143408 + - PATHOGENIC .92454 Reported in another cancer sample as somatic 33115932 surgery-fixed NS 68 ENSP00000342376.3:p.Asn115Thr ENST00000342916.7:c.344A>C 7:g.55143408A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-208-tumor 2819090 2675389 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-023-tumor 2818984 2675283 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00346T00346 2857341 2712641 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00192T00192 2857326 2712626 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-162-tumor 2819060 2675359 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 109598 2812902 2669316 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 44 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-024-tumor 2818985 2675284 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 BL-17-G34953 2905427 2759683 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51788796 COSM4680390 106250329 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000342376.3:p.Arg98Gln ENST00000342916.7:c.293G>A 7:g.55143357G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-197-tumor 2819082 2675381 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00278T00278 2857364 2712664 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00305T00305 2857328 2712628 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00357T00357 2857360 2712660 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2701162 2701162 2560066 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51822289 COSM42977 106250610 c.315G>T p.Q105H Substitution - Missense het 38 7:55143379-55143379 + - PATHOGENIC .90579 Reported in another cancer sample as somatic 28581676 surgery-fixed NS 41 ENSP00000342376.3:p.Gln105His ENST00000342916.7:c.315G>T 7:g.55143379G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732924 2732924 2591677 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 64 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-185-tumor 2819071 2675370 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-087-tumor 2819019 2675318 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00226T00226 2857365 2712665 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 BL-16-A36234 2905681 2759937 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732935 2732935 2591688 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 72 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-275-tumor 2819122 2675421 meninges NS NS NS meningioma anaplastic NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 HN_62506 1560544 1481994 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51818237 COSM122787 106256631 c.534G>T p.M178I Substitution - Missense 38 7:55146715-55146715 + - PATHOGENIC .7306 Reported in another cancer sample as somatic 21798893 surgery fresh/frozen primary ENSP00000342376.3:p.Met178Ile ENST00000342916.7:c.534G>T 7:g.55146715G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2733228 2733228 2591981 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 106239765 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 61 ENSP00000342376.3:p.Pro596Leu ENST00000342916.7:c.1787C>T 7:g.55165344C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2509046 2509046 2371381 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 106239765 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 62 ENSP00000342376.3:p.Pro596Leu ENST00000342916.7:c.1787C>T 7:g.55165344C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194728 1194728 1106623 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 109610 2812911 2669325 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 16 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00426T00426 2857346 2712646 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194730 1194730 1106625 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00264T00264 2857327 2712627 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-018-tumor 2818983 2675282 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0002PT00038T00038 2857332 2712632 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 BL-14-R46791 2905653 2759909 NS NS NS NS malignant_melanoma NS NS NS n COSV51844648 COSM6971178 106243270 c.820A>G p.T274A Substitution - Missense 38 7:55154083-55154083 + - PATHOGENIC .96224 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000342376.3:p.Thr274Ala ENST00000342916.7:c.820A>G 7:g.55154083A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0002PT00015T00015 2857336 2712636 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 LUAD-RT-S01810 1765179 1669499 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51809160 COSM382935 106241308 c.1606G>A p.V536M Substitution - Missense 38 7:55161606-55161606 + - PATHOGENIC .98051 Reported in another cancer sample as somatic 22980975 surgery - NOS primary ENSP00000342376.3:p.Val536Met ENST00000342916.7:c.1606G>A 7:g.55161606G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-46-3769-01 1781825 1685824 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51799159 COSM747427 106250791 c.1766C>T p.P589L Substitution - Missense 38 7:55165323-55165323 + - PATHOGENIC .95834 Reported in another cancer sample as somatic 418 fresh/frozen - NOS primary 57 ENSP00000342376.3:p.Pro589Leu ENST00000342916.7:c.1766C>T 7:g.55165323C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-38-4627-01 1780091 1684090 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 64 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 8LFG8F 2762947 2621206 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51839851 COSM7340115 106251623 c.1118C>A p.P373Q Substitution - Missense 38 7:55156644-55156644 + - PATHOGENIC .76649 Reported in another cancer sample as somatic 29615459 NS metastasis 45 ENSP00000342376.3:p.Pro373Gln ENST00000342916.7:c.1118C>A 7:g.55156644C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-066-tumor 2819004 2675303 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-168-tumor 2819062 2675361 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-083-tumor 2819016 2675315 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00240T00240 2857369 2712669 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-171-tumor 2819064 2675363 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-230-tumor 2819105 2675404 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-174-tumor 2819067 2675366 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 DCR10 1690659 1598936 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 106245623 c.1476C>A p.S492R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000342376.3:p.Ser492Arg ENST00000342916.7:c.1476C>A 7:g.55160316C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-02-0021-01 1910130 1798421 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 106242169 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 44 ENSP00000342376.3:p.Arg252Cys ENST00000342916.7:c.754C>T 7:g.55154017C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00414T00414 2857361 2712661 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-075-tumor 2819011 2675310 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00227T00227 2857348 2712648 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-111-tumor 2819034 2675333 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-AP-A0LM-01 1783352 1687351 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51797307 COSM1090871 106249307 c.1310C>A p.S437Y Substitution - Missense het 38 7:55160150-55160150 + - PATHOGENIC .98943 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 33 ENSP00000342376.3:p.Ser437Tyr ENST00000342916.7:c.1310C>A 7:g.55160150C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 109596 2812901 2669315 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 72 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 DCR7 1690657 1598934 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 106245623 c.1476C>A p.S492R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000342376.3:p.Ser492Arg ENST00000342916.7:c.1476C>A 7:g.55160316C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-AS-3778-01 1779806 1683805 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51831642 COSM1496684 106245349 c.988G>A p.E330K Substitution - Missense 38 7:55155928-55155928 + - PATHOGENIC .94538 Reported in another cancer sample as somatic 416 fresh/frozen - NOS primary 35 ENSP00000342376.3:p.Glu330Lys ENST00000342916.7:c.988G>A 7:g.55155928G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 B00426 2910515 2764377 ovary NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51792433 COSM6966446 106253906 c.1762G>A p.G588S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Reported in another cancer sample as somatic 33947352 surgery-fixed NS ENSP00000342376.3:p.Gly588Ser ENST00000342916.7:c.1762G>A 7:g.55165319G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2696524 2696524 2555428 central_nervous_system middle_frontal_gyrus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28201779 surgery fresh/frozen NS 56 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-014-tumor 2818981 2675280 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0154-01 1910182 1798473 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense hom 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 55 ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-121-tumor 2819042 2675341 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0002PT00018T00018 2857363 2712663 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00355T00355 2857331 2712631 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S002024 1027695 944671 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51785554 COSM21688 106239985 c.971G>T p.R324L Substitution - Missense het 38 7:55155911-55155911 + - PATHOGENIC .97287 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Arg324Leu ENST00000342916.7:c.971G>T 7:g.55155911G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 ESO-963 1890976 1780345 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV51799199 COSM1251020 106242313 c.1774G>A p.V592I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Reported in another cancer sample as somatic 23525077 surgery fresh/frozen primary 75 ENSP00000342376.3:p.Val592Ile ENST00000342916.7:c.1774G>A 7:g.55165331G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 BL-17-J45330 2905663 2759919 NS NS NS NS malignant_melanoma NS NS NS n COSV51777851 COSM1205052 106248087 c.494G>A p.R165Q Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .0375 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000342376.3:p.Arg165Gln ENST00000342916.7:c.494G>A 7:g.55146675G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2579398 2579398 2440735 NS NS NS NS malignant_melanoma NS NS NS n COSV51788796 COSM4680390 106250329 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000342376.3:p.Arg98Gln ENST00000342916.7:c.293G>A 7:g.55143357G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0219-01 1910209 1798500 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 67 ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-201-tumor 2819084 2675383 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2805811 2805811 2662548 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 31348837 surgery - NOS NS ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194736 1194736 1106631 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 618-1503-04TD 1921502 1808820 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51797215 COSM145360 106244577 c.967G>A p.V323I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Reported in another cancer sample as somatic 340 blood NS ENSP00000342376.3:p.Val323Ile ENST00000342916.7:c.967G>A 7:g.55155907G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2733218 2733218 2591971 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 42 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S001005 1027699 944675 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2785975 2785975 2643435 large_intestine colon ascending NS carcinoma neuroendocrine_carcinoma NS NS n COSV51781835 COSM174732 106241611 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Reported in another cancer sample as somatic 28730258 surgery-fixed primary 61 ENSP00000342376.3:p.Glu114Lys ENST00000342916.7:c.340G>A 7:g.55143404G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00207T00207 2857359 2712659 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-156-tumor 2819056 2675355 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00143T00143 2857358 2712658 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 OX-CO-2_R3_Cetux 2841378 2696927 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 106246290 c.1391C>T p.S464L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000342376.3:p.Ser464Leu ENST00000342916.7:c.1391C>T 7:g.55160231C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732896 2732896 2591649 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 58 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2808102 2808102 2664786 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 31258848 surgery-fixed NS 60 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00243T00243 2857340 2712640 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00190T00190 2857342 2712642 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0125-01 1910168 1798459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 64 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-02-0016-01 1910129 1798420 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 50 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194725 1194725 1106620 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 106240722 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Ala289Asp ENST00000342916.7:c.866C>A 7:g.55154129C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S001095 1027691 944667 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 SJHGG120_D 2307435 2172639 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 24705251 surgery - NOS NS 12 ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00383T00383 2857375 2712675 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-175-tumor 2819068 2675367 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2579649 2579649 2440986 NS NS NS NS malignant_melanoma NS NS NS n COSV51781835 COSM174732 106241611 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000342376.3:p.Glu114Lys ENST00000342916.7:c.340G>A 7:g.55143404G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-02-0089-01 1910158 1798449 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense hom 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 54 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-078-tumor 2819014 2675313 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-057-tumor 2818998 2675297 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-02-0007-01 1910125 1798416 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 106241473 c.787A>C p.T263P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 42 ENSP00000342376.3:p.Thr263Pro ENST00000342916.7:c.787A>C 7:g.55154050A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2625627 2625627 2486039 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51767687 COSM6191352 106239215 c.1747G>A p.A583T Substitution - Missense het 38 7:55165304-55165304 + - PATHOGENIC .98656 Reported in another cancer sample as somatic 26488212 surgery-fixed NS ENSP00000342376.3:p.Ala583Thr ENST00000342916.7:c.1747G>A 7:g.55165304G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 5-GE101-T1 2869805 2724802 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51822498 COSM3266565 106254394 c.917C>T p.S306L Substitution - Missense 38 7:55155857-55155857 + - PATHOGENIC .98807 Reported in another cancer sample as somatic 26950094 surgery - NOS NS 81 ENSP00000342376.3:p.Ser306Leu ENST00000342916.7:c.917C>T 7:g.55155857C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2840788 2840788 2696348 prostate NS NS NS carcinoma NS NS NS n COSV51785413 COSM1176673 106243142 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 31874108 surgery-fixed metastasis ENSP00000342376.3:p.Arg252His ENST00000342916.7:c.755G>A 7:g.55154018G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00443T00443 2857349 2712649 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-050-tumor 2818996 2675295 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-RR-A6KC-01 2339255 2204238 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 106242169 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 NS primary 55 ENSP00000342376.3:p.Arg252Cys ENST00000342916.7:c.754C>T 7:g.55154017C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0004491-T01-IM5 2720890 2579711 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28481359 surgery - NOS primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 SNU-C2B 2302010 2167293 large_intestine colon right NS carcinoma adenocarcinoma NS NS y COSV51777851 COSM1205052 106248087 c.494G>A p.R165Q Substitution - Missense het 38 7:55146675-55146675 + - NEUTRAL .0375 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000342376.3:p.Arg165Gln ENST00000342916.7:c.494G>A 7:g.55146675G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194737 1194737 1106632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 pros_01_dx 2688203 2547185 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 544 NS primary 41 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0004119-T01-IM5 2720520 2579341 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 106242169 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg252Cys ENST00000342916.7:c.754C>T 7:g.55154017C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-08-0380-01 1910239 1798530 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779162 COSM21689 106239765 c.1787C>T p.P596L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 74 ENSP00000342376.3:p.Pro596Leu ENST00000342916.7:c.1787C>T 7:g.55165344C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0237-01 1910211 1798502 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense hom 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 75 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-196-tumor 2819081 2675380 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S001067 1027687 944663 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 106241473 c.787A>C p.T263P Substitution - Missense hom 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Thr263Pro ENST00000342916.7:c.787A>C 7:g.55154050A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 HN_62995 1560583 1482033 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825459 COSM122789 106244524 c.1423A>G p.I475V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Reported in another cancer sample as somatic 21798893 surgery fresh/frozen primary ENSP00000342376.3:p.Ile475Val ENST00000342916.7:c.1423A>G 7:g.55160263A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 EXTERN_MELA_20140526_088 2839362 2695128 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 106241928 c.1168C>A p.Q390K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000342376.3:p.Gln390Lys ENST00000342916.7:c.1168C>A 7:g.55156793C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 924777 924777 841550 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51863722 COSM13560 106248227 c.1871G>T p.C624F Substitution - Missense het 38 7:55165428-55165428 + - PATHOGENIC .99905 Reported in another cancer sample as somatic 16133419 NS NS ENSP00000342376.3:p.Cys624Phe ENST00000342916.7:c.1871G>T 7:g.55165428G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S001108 1027693 944669 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 17177598 cell-line NS ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00237T00237 2857324 2712624 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194731 1194731 1106626 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T155 1861137 1752078 endometrium NS NS NS carcinoma serous_carcinoma NS NS y COSV51785413 COSM1176673 106243142 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 23104009 surgery fresh/frozen primary ENSP00000342376.3:p.Arg252His ENST00000342916.7:c.755G>A 7:g.55154018G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2733227 2733227 2591980 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 106239765 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 61 ENSP00000342376.3:p.Pro596Leu ENST00000342916.7:c.1787C>T 7:g.55165344C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00173T00173 2857372 2712672 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-070-tumor 2819006 2675305 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 109594 2812900 2669314 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 66 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00004T00004 2857337 2712637 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S003763 1027686 944662 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-BS-A0UV-01 1783478 1687477 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51773524 COSM1090858 106240218 c.418T>G p.L140V Substitution - Missense het 38 7:55143482-55143482 + - NEUTRAL .25717 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 55 ENSP00000342376.3:p.Leu140Val ENST00000342916.7:c.418T>G 7:g.55143482T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00178T00178 2857362 2712662 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MG-198-tumor 2819083 2675382 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PF08 2560049 2421473 large_intestine colon sigmoid NS adenoma tubular NS NS n COSV51779162 COSM21689 106239765 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 27609830 surgery-fixed NS ENSP00000342376.3:p.Pro596Leu ENST00000342916.7:c.1787C>T 7:g.55165344C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0649 2107982 1985843 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51791901 COSM2151461 106255456 c.991G>A p.G331R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .96902 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Gly331Arg ENST00000342916.7:c.991G>A 7:g.55155931G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2841857 2841857 2697406 soft_tissue fibrous_tissue_and_uncertain_origin trunk NS desmoid_tumour-fibromatosis NS NS NS n COSV51777833 COSM4680394 106243472 c.1580G>A p.R527Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Reported in another cancer sample as somatic 32099073 surgery-fixed NS 27 ENSP00000342376.3:p.Arg527Gln ENST00000342916.7:c.1580G>A 7:g.55161580G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-02-0046-01 1910140 1798431 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 61 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2585421 2585421 2446585 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576891 COSM9396331 106246095 c.1400A>C p.K467T Substitution - Missense het 38 7:55160240-55160240 + - NEUTRAL .10442 Reported in another cancer sample as somatic 25623215 surgery - NOS recurrent ENSP00000342376.3:p.Lys467Thr ENST00000342916.7:c.1400A>C 7:g.55160240A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732923 2732923 2591676 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 64 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732934 2732934 2591687 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 72 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2840787 2840787 2696347 prostate NS NS NS carcinoma NS NS NS n COSV51785413 COSM1176673 106243142 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000342376.3:p.Arg252His ENST00000342916.7:c.755G>A 7:g.55154018G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 DCR9 1690658 1598935 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 106245623 c.1476C>A p.S492R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000342376.3:p.Ser492Arg ENST00000342916.7:c.1476C>A 7:g.55160316C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CSCC-40-T 2292477 2158541 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51858853 COSM4512041 106262116 c.889C>T p.R297C Substitution - Missense het 38 7:55154152-55154152 + - PATHOGENIC .97012 Confirmed somatic variant 25303977 surgery fresh/frozen metastasis 49 ENSP00000342376.3:p.Arg297Cys ENST00000342916.7:c.889C>T 7:g.55154152C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732912 2732912 2591665 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 106240722 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 60 ENSP00000342376.3:p.Ala289Asp ENST00000342916.7:c.866C>A 7:g.55154129C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PD_06 2688647 2547629 skin face NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51852113 COSM4501266 106247110 c.584C>T p.P195L Substitution - Missense het 38 7:55151318-55151318 + - NEUTRAL .31382 Confirmed somatic variant 24662767 surgery fresh/frozen NS 75 ENSP00000342376.3:p.Pro195Leu ENST00000342916.7:c.584C>T 7:g.55151318C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2732925 2732925 2591678 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 75 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DU-7012-01 2194261 2062539 central_nervous_system brain NS NS glioma NS NS NS y COSV51774829 COSM1451549 106240536 c.767A>G p.D256G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 545 NS NS 74 ENSP00000342376.3:p.Asp256Gly ENST00000342916.7:c.767A>G 7:g.55154030A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2841184 2841184 2696744 prostate NS NS NS carcinoma NS NS NS n COSV104577128 COSM9497116 106264637 c.1471A>G p.I491V Substitution - Missense 38 7:55160311-55160311 + - NEUTRAL .12941 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000342376.3:p.Ile491Val ENST00000342916.7:c.1471A>G 7:g.55160311A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 NPC0001PT00407T00407 2857330 2712630 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194738 1194738 1106633 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 112509 1520625 1443000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51833788 COSM94181 106261363 c.1675C>T p.H559Y Substitution - Missense 38 7:55163776-55163776 + - PATHOGENIC .97598 Confirmed somatic variant 20668451 NS primary ENSP00000342376.3:p.His559Tyr ENST00000342916.7:c.1675C>T 7:g.55163776C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S004384 1027694 944670 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-AP-A051-01 1783330 1687329 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51837186 COSM1090861 106245627 c.442G>A p.V148M Substitution - Missense het 38 7:55146623-55146623 + - PATHOGENIC .99004 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 69 ENSP00000342376.3:p.Val148Met ENST00000342916.7:c.442G>A 7:g.55146623G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GBM19-I1 2813465 2669857 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GB013T 2633978 2494374 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51855854 COSM6355744 106255650 c.977G>T p.C326F Substitution - Missense 38 7:55155917-55155917 + - PATHOGENIC .99445 Confirmed somatic variant 672 NS primary ENSP00000342376.3:p.Cys326Phe ENST00000342916.7:c.977G>T 7:g.55155917G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 U373 2491105 2353751 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51804471 COSM5712404 106270608 c.1523C>T p.A508V Substitution - Missense 38 7:55161523-55161523 + - NEUTRAL .21884 Confirmed somatic variant 26496030 cell-line NS ENSP00000342376.3:p.Ala508Val ENST00000342916.7:c.1523C>T 7:g.55161523C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GBM13-I3 2813477 2669869 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28263318 surgery fresh/frozen NS 55 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0007024-T01-IM5 2723398 2582219 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51786507 COSM6955643 106255076 c.1118C>T p.P373L Substitution - Missense het 38 7:55156644-55156644 + - PATHOGENIC .86501 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Pro373Leu ENST00000342916.7:c.1118C>T 7:g.55156644C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0007024-T01-IM5 2723398 2582219 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 5-VS033-T2 2869855 2724852 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51776559 COSM4892884 106242415 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 26950094 surgery - NOS NS 73 ENSP00000342376.3:p.Pro100Ser ENST00000342916.7:c.298C>T 7:g.55143362C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 5-VS033-T2 2869855 2724852 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51790737 COSM3639739 106262598 c.1621C>T p.L541F Substitution - Missense 38 7:55161621-55161621 + - NEUTRAL .0484 Confirmed somatic variant 26950094 surgery - NOS NS 73 ENSP00000342376.3:p.Leu541Phe ENST00000342916.7:c.1621C>T 7:g.55161621C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GB051T 2634016 2494412 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51846086 COSM6354719 106266719 c.178G>A p.V60M Substitution - Missense 38 7:55142375-55142375 + - PATHOGENIC .96004 Confirmed somatic variant 672 NS primary ENSP00000342376.3:p.Val60Met ENST00000342916.7:c.178G>A 7:g.55142375G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0012113-T01-IM5 2727253 2586074 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51851189 COSM6982714 106246698 c.1405T>G p.L469V Substitution - Missense het 38 7:55160245-55160245 + - NEUTRAL .32338 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Leu469Val ENST00000342916.7:c.1405T>G 7:g.55160245T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MSU2-a 2809971 2666633 large_intestine caecum NS NS adenoma villous NS NS y COSV51784286 COSM6652281 106243308 c.116C>T p.T39M Substitution - Missense 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000342376.3:p.Thr39Met ENST00000342916.7:c.116C>T 7:g.55142313C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-14-0813-01 1337991 1248376 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779162 COSM21689 106239765 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 329 surgery fresh/frozen NS 78 ENSP00000342376.3:p.Pro596Leu ENST00000342916.7:c.1787C>T 7:g.55165344C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 400_R4 2910227 2764189 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV104577128 COSM9497116 106264637 c.1471A>G p.I491V Substitution - Missense het 38 7:55160311-55160311 + - NEUTRAL .12941 Confirmed somatic variant 27639803 short-term culture NS 69 ENSP00000342376.3:p.Ile491Val ENST00000342916.7:c.1471A>G 7:g.55160311A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 ESCC_35 2479543 2342303 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51774192 COSM5628704 106257635 c.596G>C p.C199S Substitution - Missense 38 7:55151330-55151330 + - PATHOGENIC .99573 Confirmed somatic variant 26873401 NS NS 68 ENSP00000342376.3:p.Cys199Ser ENST00000342916.7:c.596G>C 7:g.55151330G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GB057T 2634022 2494418 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 672 NS primary ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-FG-6692-01 2194411 2062689 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 63 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 non-ocular_carcinoma_3 2580640 2441977 skin neck NS NS adnexal_tumour sebaceous_carcinoma NS NS n COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 27287813 surgery-fixed primary ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-16-1045-01 1338027 1248412 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 106241473 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 surgery fresh/frozen NS 49 ENSP00000342376.3:p.Thr263Pro ENST00000342916.7:c.787A>C 7:g.55154050A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DF-A2L0-01 2457392 2320229 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51809160 COSM382935 106241308 c.1606G>A p.V536M Substitution - Missense 38 7:55161606-55161606 + - PATHOGENIC .98051 Confirmed somatic variant 419 NS primary 60 ENSP00000342376.3:p.Val536Met ENST00000342916.7:c.1606G>A 7:g.55161606G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2876663 2876663 2731178 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 surgery fresh/frozen NS 60 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0000677-T01-IM3 2715765 2574586 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51860516 COSM6911906 106250352 c.1143C>G p.F381L Substitution - Missense het 38 7:55156768-55156768 + - PATHOGENIC .96387 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Phe381Leu ENST00000342916.7:c.1143C>G 7:g.55156768C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 ICGC_GBM53_tumor 2634861 2495257 central_nervous_system brain NS NS primitive_neuroectodermal_tumour-medulloblastoma NS NS NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 379 NS primary 5 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51807036 COSM2151966 106245927 c.1787C>G p.P596R Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99615 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000342376.3:p.Pro596Arg ENST00000342916.7:c.1787C>G 7:g.55165344C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 106240722 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000342376.3:p.Ala289Asp ENST00000342916.7:c.866C>A 7:g.55154129C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009856-T01-IM5 2725695 2584516 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51844648 COSM6971178 106243270 c.820A>G p.T274A Substitution - Missense het 38 7:55154083-55154083 + - PATHOGENIC .96224 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000342376.3:p.Thr274Ala ENST00000342916.7:c.820A>G 7:g.55154083A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 004 2492942 2355556 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour benign NS n COSV51768130 COSM21684 106241473 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 26437033 NS NS ENSP00000342376.3:p.Thr263Pro ENST00000342916.7:c.787A>C 7:g.55154050A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-12-3652-01 2120285 1994521 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51800797 COSM3412178 106244249 c.755G>C p.R252P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 329 NS NS 60 ENSP00000342376.3:p.Arg252Pro ENST00000342916.7:c.755G>C 7:g.55154018G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0013374-T01-IM5 2803847 2660597 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51793336 COSM6214981 106255345 c.1663T>C p.C555R Substitution - Missense het 38 7:55163764-55163764 + - PATHOGENIC .99407 Confirmed somatic variant 29316426 surgery-fixed primary 79 ENSP00000342376.3:p.Cys555Arg ENST00000342916.7:c.1663T>C 7:g.55163764T>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003104-T01-IM5 2719600 2578421 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51779162 COSM21689 106239765 c.1787C>T p.P596L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Pro596Leu ENST00000342916.7:c.1787C>T 7:g.55165344C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003360-T01-IM5 2719851 2578672 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0749-01 1337861 1248246 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849279 COSM6923107 106242080 c.1770C>A p.H590Q Substitution - Missense het 38 7:55165327-55165327 + - PATHOGENIC .98427 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.His590Gln ENST00000342916.7:c.1770C>A 7:g.55165327C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849240 COSM6923103 106242060 c.1759G>A p.D587N Substitution - Missense het 38 7:55165316-55165316 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Asp587Asn ENST00000342916.7:c.1759G>A 7:g.55165316G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849201 COSM6923099 106242034 c.1331A>T p.N444I Substitution - Missense het 38 7:55160171-55160171 + - PATHOGENIC .8398 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Asn444Ile ENST00000342916.7:c.1331A>T 7:g.55160171A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-19-2620-01 2120303 1994539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 70 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S02279_1 2480887 2343632 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV51810698 COSM5683869 106253157 c.1337C>A p.T446K Substitution - Missense 38 7:55160177-55160177 + - NEUTRAL .09422 Confirmed somatic variant 26168399 surgery fresh/frozen primary 58 ENSP00000342376.3:p.Thr446Lys ENST00000342916.7:c.1337C>A 7:g.55160177C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0004971-T01-IM5 2721381 2580202 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PD6907a 1504118 1426996 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51857264 COSM4384115 106259919 c.727C>T p.P243S Substitution - Missense 38 7:55152644-55152644 + - PATHOGENIC .99273 Confirmed somatic variant 24030381 NS NS ENSP00000342376.3:p.Pro243Ser ENST00000342916.7:c.727C>T 7:g.55152644C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 R098-I1 2813503 2669895 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 106241525 c.809A>G p.Y270C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 28263318 surgery fresh/frozen NS 51 ENSP00000342376.3:p.Tyr270Cys ENST00000342916.7:c.809A>G 7:g.55154072A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-FP-7829-01 2198081 2066359 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51829933 COSM3881812 106249729 c.971G>A p.R324H Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .95186 Confirmed somatic variant 541 NS NS 69 ENSP00000342376.3:p.Arg324His ENST00000342916.7:c.971G>A 7:g.55155911G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GBM19-I2 2813466 2669858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0004846-T01-IM5 2721249 2580070 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51779091 COSM2155593 106245463 c.1088C>T p.T363I Substitution - Missense het 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Thr363Ile ENST00000342916.7:c.1088C>T 7:g.55156614C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-D8-A1JF-01 1900052 1788736 breast NS NS NS carcinoma NS NS NS y COSV51781835 COSM174732 106241611 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 414 fresh/frozen - NOS primary 79 ENSP00000342376.3:p.Glu114Lys ENST00000342916.7:c.340G>A 7:g.55143404G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 LC_S35 1863746 1754637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 22975805 surgery fresh/frozen primary 82 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0014258-T01-IM6 2803906 2660656 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51826193 COSM7340403 106247331 c.458A>G p.N153S Substitution - Missense het 38 7:55146639-55146639 + - PATHOGENIC .99355 Confirmed somatic variant 29316426 surgery-fixed primary 69 ENSP00000342376.3:p.Asn153Ser ENST00000342916.7:c.458A>G 7:g.55146639A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003222-T01-IM5 2719716 2578537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51841941 COSM6927106 106240938 c.846G>T p.E282D Substitution - Missense het 38 7:55154109-55154109 + - NEUTRAL .06117 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000342376.3:p.Glu282Asp ENST00000342916.7:c.846G>T 7:g.55154109G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-19-1789 2108040 1985901 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51850088 COSM2156010 106250777 c.1000C>T p.R334C Substitution - Missense 38 7:55155940-55155940 + - PATHOGENIC .91604 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Arg334Cys ENST00000342916.7:c.1000C>T 7:g.55155940C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006399-T01-IM5 2722775 2581596 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843352 COSM6950555 106254796 c.530C>T p.S177L Substitution - Missense het 38 7:55146711-55146711 + - NEUTRAL .28714 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Ser177Leu ENST00000342916.7:c.530C>T 7:g.55146711C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-02-0003 2107930 1985791 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51809225 COSM35825 106252732 c.1859G>A p.C620Y Substitution - Missense 38 7:55165416-55165416 + - PATHOGENIC .99893 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Cys620Tyr ENST00000342916.7:c.1859G>A 7:g.55165416G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0000906-T01-IM3 2716233 2575054 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765787 COSM2149971 106241217 c.910C>T p.H304Y Substitution - Missense het 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.His304Tyr ENST00000342916.7:c.910C>T 7:g.55155850C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 LICA-CN-HCC089T 2634136 2494532 liver NS NS NS other neoplasm NS NS y COSV51832020 COSM5822378 106253729 c.1742A>T p.Q581L Substitution - Missense 38 7:55165299-55165299 + - PATHOGENIC .9451 Confirmed somatic variant 660 NS primary 48 ENSP00000342376.3:p.Gln581Leu ENST00000342916.7:c.1742A>T 7:g.55165299A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-QH-A6CX-01 2263100 2130084 central_nervous_system brain NS NS glioma NS NS NS y COSV51785554 COSM21688 106239985 c.971G>T p.R324L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 545 NS primary 66 ENSP00000342376.3:p.Arg324Leu ENST00000342916.7:c.971G>T 7:g.55155911G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MSU3-a 2809972 2666634 large_intestine colon transverse NS adenoma tubulovillous NS NS y COSV99292326 COSM9176305 106252565 c.1579C>T p.R527W Substitution - Missense 38 7:55161579-55161579 + - NEUTRAL .28879 Confirmed somatic variant 26336987 surgery fresh/frozen primary 51 ENSP00000342376.3:p.Arg527Trp ENST00000342916.7:c.1579C>T 7:g.55161579C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2014_Lung_sq_25_T 2744896 2603599 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 74 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-AO-A12G-01 1899795 1788479 breast NS NS NS carcinoma NS NS NS y COSV51772564 COSM453241 106248852 c.817A>G p.T273A Substitution - Missense 38 7:55154080-55154080 + - PATHOGENIC .94785 Confirmed somatic variant 414 fresh/frozen - NOS primary 75 ENSP00000342376.3:p.Thr273Ala ENST00000342916.7:c.817A>G 7:g.55154080A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MTP18_T1 2875797 2730359 pancreas NS NS NS other dysplasia-in_situ_neoplasm NS NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 32796935 surgery-fixed NS 74 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0001171-T01-IM3 2716747 2575568 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51850219 COSM6915112 106243252 c.1846G>T p.V616L Substitution - Missense het 38 7:55165403-55165403 + - PATHOGENIC .98789 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Val616Leu ENST00000342916.7:c.1846G>T 7:g.55165403G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0008258-T01-IM5 2724397 2583218 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-05-4382-01 1780053 1684052 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99288202 COSM7821254 106249686 c.1633G>C p.E545Q Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9875 Confirmed somatic variant 417 fresh/frozen - NOS primary 68 ENSP00000342376.3:p.Glu545Gln ENST00000342916.7:c.1633G>C 7:g.55163734G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-05-4382-01 1780053 1684052 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99288189 COSM7821080 106249665 c.665G>T p.R222L Substitution - Missense 38 7:55152582-55152582 + - PATHOGENIC .99698 Confirmed somatic variant 417 fresh/frozen - NOS primary 68 ENSP00000342376.3:p.Arg222Leu ENST00000342916.7:c.665G>T 7:g.55152582G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-2565 2108006 1985867 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DU-8162-01 2194248 2062526 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 61 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GBM_IV-39 2354294 2218452 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51778955 COSM4967262 106248952 c.680C>A p.S227Y Substitution - Missense 38 7:55152597-55152597 + - NEUTRAL .32595 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000342376.3:p.Ser227Tyr ENST00000342916.7:c.680C>A 7:g.55152597C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0002599-T01-IM3 2718855 2577676 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51832234 COSM6923248 106265828 c.1532C>A p.S511Y Substitution - Missense het 38 7:55161532-55161532 + - PATHOGENIC .99176 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ser511Tyr ENST00000342916.7:c.1532C>A 7:g.55161532C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-E1-A7YM-01 2457423 2320260 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 63 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-HT-A61C-01 2386268 2249100 central_nervous_system brain NS NS glioma NS NS NS y COSV51768130 COSM21684 106241473 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 545 NS primary 66 ENSP00000342376.3:p.Thr263Pro ENST00000342916.7:c.787A>C 7:g.55154050A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009327-T01-IM5 2725273 2584094 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0005127-T02-IM5 2721531 2580352 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51802355 COSM6941144 106240473 c.1154C>T p.P385L Substitution - Missense het 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Pro385Leu ENST00000342916.7:c.1154C>T 7:g.55156779C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0005127-T02-IM5 2721531 2580352 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51794869 COSM4362780 106240452 c.574C>T p.P192S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Pro192Ser ENST00000342916.7:c.574C>T 7:g.55151308C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194722 1194722 1106617 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51824149 COSM29338 106240652 c.178G>C p.V60L Substitution - Missense 38 7:55142375-55142375 + - PATHOGENIC .98023 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Val60Leu ENST00000342916.7:c.178G>C 7:g.55142375G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0010613-T01-IM5 2726312 2585133 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003128-T01-IM5 2719622 2578443 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 YUKAT 2439331 2302172 skin NS NS NS malignant_melanoma NS NS NS y COSV51838161 COSM5407720 106240812 c.994C>T p.P332S Substitution - Missense het 38 7:55155934-55155934 + - PATHOGENIC .91925 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 78 ENSP00000342376.3:p.Pro332Ser ENST00000342916.7:c.994C>T 7:g.55155934C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 Br001X 1312986 1223895 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51797037 COSM40998 106266779 c.1804G>C p.E602Q Substitution - Missense hom 38 7:55165361-55165361 + - PATHOGENIC .99549 Confirmed somatic variant 18772396 xenograft primary 4 ENSP00000342376.3:p.Glu602Gln ENST00000342916.7:c.1804G>C 7:g.55165361G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-BR-4184-01 2198083 2066361 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51818237 COSM122787 106256631 c.534G>T p.M178I Substitution - Missense 38 7:55146715-55146715 + - PATHOGENIC .7306 Confirmed somatic variant 541 NS NS 70 ENSP00000342376.3:p.Met178Ile ENST00000342916.7:c.534G>T 7:g.55146715G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-ER-A19E-06 2121716 1995952 skin NS NS NS malignant_melanoma NS NS NS y COSV51817262 COSM3639733 106264740 c.955G>A p.E319K Substitution - Missense 38 7:55155895-55155895 + - PATHOGENIC .99356 Confirmed somatic variant 540 NS NS 36 ENSP00000342376.3:p.Glu319Lys ENST00000342916.7:c.955G>A 7:g.55155895G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-VM-A8CD-01 2262980 2129964 central_nervous_system brain NS NS glioma NS NS NS y COSV99295978 COSM8269849 106254879 c.1747G>T p.A583S Substitution - Missense 38 7:55165304-55165304 + - PATHOGENIC .98882 Confirmed somatic variant 545 NS primary 58 ENSP00000342376.3:p.Ala583Ser ENST00000342916.7:c.1747G>T 7:g.55165304G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-VM-A8CD-01 2262980 2129964 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS primary 58 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51792433 COSM6966446 106253906 c.1762G>A p.G588S Substitution - Missense het 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Gly588Ser ENST00000342916.7:c.1762G>A 7:g.55165319G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S001090 1027692 944668 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-14-1034-01 2178234 2046532 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51775191 COSM1451530 106240644 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 329 NS NS 60 ENSP00000342376.3:p.Gly63Arg ENST00000342916.7:c.187G>A 7:g.55142384G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 Br230T 1313049 1223958 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 surgery - NOS primary 46 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 13T 2139248 2008776 upper_aerodigestive_tract mouth gingiva NS carcinoma squamous_cell_carcinoma NS NS y COSV51815394 COSM3715755 106243702 c.738C>A p.S246R Substitution - Missense 38 7:55152655-55152655 + - NEUTRAL .15461 Confirmed somatic variant 24292195 NS NS ENSP00000342376.3:p.Ser246Arg ENST00000342916.7:c.738C>A 7:g.55152655C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0005400-T01-IM5 2721802 2580623 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51781835 COSM174732 106241611 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000342376.3:p.Glu114Lys ENST00000342916.7:c.340G>A 7:g.55143404G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009357-T01-IM5 2725300 2584121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PD25645c 2843020 2698474 skin mucosal sinonasal NS malignant_melanoma NS NS NS y COSV104576411 COSM9505912 106269790 c.881A>T p.K294M Substitution - Missense 38 7:55154144-55154144 + - PATHOGENIC .88176 Confirmed somatic variant 30664638 surgery-fixed primary 58 ENSP00000342376.3:p.Lys294Met ENST00000342916.7:c.881A>T 7:g.55154144A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-CG-5721-01 2198017 2066295 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51782832 COSM3881808 106254474 c.739G>A p.D247N Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .98807 Confirmed somatic variant 541 NS NS 58 ENSP00000342376.3:p.Asp247Asn ENST00000342916.7:c.739G>A 7:g.55152656G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-22-4609-01 2195227 2063505 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51827895 COSM3412174 106241589 c.685A>T p.S229C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 418 NS NS 81 ENSP00000342376.3:p.Ser229Cys ENST00000342916.7:c.685A>T 7:g.55152602A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009527-T01-IM5 2725444 2584265 skin NS NS NS malignant_melanoma NS NS NS n COSV51794946 COSM6969229 106240088 c.353_354delinsTT p.A118V Substitution - Missense het 38 7:55143417-55143418 + - Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Ala118Val ENST00000342916.7:c.353_354delinsTT 7:g.55143417_55143418delinsTT EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-FS-A1ZK-06 2121762 1995998 skin NS NS NS malignant_melanoma NS NS NS y COSV51790737 COSM3639739 106262598 c.1621C>T p.L541F Substitution - Missense 38 7:55161621-55161621 + - NEUTRAL .0484 Confirmed somatic variant 540 NS NS 68 ENSP00000342376.3:p.Leu541Phe ENST00000342916.7:c.1621C>T 7:g.55161621C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194727 1194727 1106622 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-26-1439 2108054 1985915 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-GN-A8LN-01 2339478 2204461 skin NS NS NS malignant_melanoma NS NS NS y COSV99295991 COSM7976081 106253644 c.1135G>A p.D379N Substitution - Missense 38 7:55156760-55156760 + - PATHOGENIC .99676 Confirmed somatic variant 540 NS primary 68 ENSP00000342376.3:p.Asp379Asn ENST00000342916.7:c.1135G>A 7:g.55156760G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-GN-A8LN-01 2339478 2204461 skin NS NS NS malignant_melanoma NS NS NS y COSV99295987 COSM7976353 106253624 c.815C>T p.P272L Substitution - Missense 38 7:55154078-55154078 + - PATHOGENIC .98876 Confirmed somatic variant 540 NS primary 68 ENSP00000342376.3:p.Pro272Leu ENST00000342916.7:c.815C>T 7:g.55154078C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0747-01 1337860 1248245 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 53 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2492702 2492702 2355317 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 106250485 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000342376.3:p.His47Tyr ENST00000342916.7:c.139C>T 7:g.55142336C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T341 2658331 2518490 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51784286 COSM6652281 106243308 c.116C>T p.T39M Substitution - Missense 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 27149842 NS NS 66.58 ENSP00000342376.3:p.Thr39Met ENST00000342916.7:c.116C>T 7:g.55142313C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-CV-7250-01 2193784 2062062 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51827895 COSM3412174 106241589 c.685A>T p.S229C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 627 NS NS 64 ENSP00000342376.3:p.Ser229Cys ENST00000342916.7:c.685A>T 7:g.55152602A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0010004-T01-IM5 2725823 2584644 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 W16T 2745047 2603750 thyroid NS NS NS carcinoma NS NS NS y COSV51794993 COSM6399094 106247891 c.5G>A p.R2Q Substitution - Missense 38 7:55019282-55019282 + - NEUTRAL .46409 Confirmed somatic variant 676 NS primary 40 ENSP00000342376.3:p.Arg2Gln ENST00000342916.7:c.5G>A 7:g.55019282G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2011-2283:2012-316-T 2297701 2163302 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51817336 COSM4604310 106262331 c.1376G>C p.G459A Substitution - Missense hom 38 7:55160216-55160216 + - PATHOGENIC .99469 Confirmed somatic variant 25056374 surgery-fixed NS ENSP00000342376.3:p.Gly459Ala ENST00000342916.7:c.1376G>C 7:g.55160216G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-S9-A7R2-01 2263272 2130256 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 69 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2857119 2857119 2712419 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV105110043 COSM9533927 106257180 c.175G>A p.E59K Substitution - Missense 38 7:55142372-55142372 + - PATHOGENIC .93877 Confirmed somatic variant 25096233 surgery - NOS NS ENSP00000342376.3:p.Glu59Lys ENST00000342916.7:c.175G>A 7:g.55142372G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-81-5910-01 2120398 1994634 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 106242169 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 NS NS 64 ENSP00000342376.3:p.Arg252Cys ENST00000342916.7:c.754C>T 7:g.55154017C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-QB-AA9O-06 2339489 2204472 skin NS NS NS malignant_melanoma NS NS NS y COSV51785510 COSM6957413 106239256 c.1102G>A p.D368N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 540 NS NS 73 ENSP00000342376.3:p.Asp368Asn ENST00000342916.7:c.1102G>A 7:g.55156628G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0001582-T01-IM3 2717588 2576409 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769747 COSM297803 106253755 c.907G>C p.D303H Substitution - Missense het 38 7:55155847-55155847 + - PATHOGENIC .99461 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Asp303His ENST00000342916.7:c.907G>C 7:g.55155847G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S001092 1027684 944660 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2733978 2733978 2592705 soft_tissue fat NS NS liposarcoma NS NS NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 29731991 surgery-fixed recurrent ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 B42-S1 2732496 2591261 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV104576683 COSM9498592 106252404 c.958G>C p.E320Q Substitution - Missense 38 7:55155898-55155898 + - PATHOGENIC .98914 Confirmed somatic variant 29244145 surgery fresh/frozen primary 70.1 ENSP00000342376.3:p.Glu320Gln ENST00000342916.7:c.958G>C 7:g.55155898G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 DD282_Org 2749235 2607934 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51784286 COSM6652281 106243308 c.116C>T p.T39M Substitution - Missense het 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 29703791 organoid culture primary 81 ENSP00000342376.3:p.Thr39Met ENST00000342916.7:c.116C>T 7:g.55142313C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 SJHGG029_R 2307362 2172566 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 24705251 surgery - NOS recurrent 4 ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T1196 2658782 2518941 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51797600 COSM5575629 106250312 c.391G>A p.G131R Substitution - Missense 38 7:55143455-55143455 + - PATHOGENIC .99768 Confirmed somatic variant 27149842 NS NS 70.83 ENSP00000342376.3:p.Gly131Arg ENST00000342916.7:c.391G>A 7:g.55143455G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-CD-A4MI-01 2198040 2066318 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51771322 COSM3881814 106246507 c.1051A>G p.I351V Substitution - Missense 38 7:55156577-55156577 + - PATHOGENIC .89527 Confirmed somatic variant 541 NS NS 62 ENSP00000342376.3:p.Ile351Val ENST00000342916.7:c.1051A>G 7:g.55156577A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0007771-T01-IM5 2724004 2582825 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51862622 COSM6959670 106239533 c.1322T>G p.V441G Substitution - Missense het 38 7:55160162-55160162 + - PATHOGENIC .9258 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Val441Gly ENST00000342916.7:c.1322T>G 7:g.55160162T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0008346-T01-IM5 2787024 2644447 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51838649 COSM6962468 106255948 c.412A>G p.R138G Substitution - Missense hom 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000342376.3:p.Arg138Gly ENST00000342916.7:c.412A>G 7:g.55143476A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 ccRCC-90 1980826 1867072 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51815313 COSM1661639 106257475 c.673G>T p.G225C Substitution - Missense 38 7:55152590-55152590 + - PATHOGENIC .99717 Confirmed somatic variant 23797736 NS NS ENSP00000342376.3:p.Gly225Cys ENST00000342916.7:c.673G>T 7:g.55152590G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CRC403 2730857 2589626 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105863818 COSM10064830 106245438 c.1061C>T p.T354M Substitution - Missense 38 7:55156587-55156587 + - PATHOGENIC .97048 Confirmed somatic variant 26416732 xenograft metastasis ENSP00000342376.3:p.Thr354Met ENST00000342916.7:c.1061C>T 7:g.55156587C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194734 1194734 1106629 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-19-2621-01 2178211 2046509 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51863722 COSM13560 106248227 c.1871G>T p.C624F Substitution - Missense 38 7:55165428-55165428 + - PATHOGENIC .99905 Confirmed somatic variant 329 NS NS 83 ENSP00000342376.3:p.Cys624Phe ENST00000342916.7:c.1871G>T 7:g.55165428G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-12-0657-01 2178279 2046577 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99286086 COSM7481785 106256695 c.133G>A p.E45K Substitution - Missense 38 7:55142330-55142330 + - PATHOGENIC .99554 Confirmed somatic variant 329 NS NS 69 ENSP00000342376.3:p.Glu45Lys ENST00000342916.7:c.133G>A 7:g.55142330G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DU-6410-01 2194391 2062669 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 56 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PL9 2492972 2355586 breast NS NS NS carcinoma lobular_carcinoma pleomorphic NS y COSV105110769 COSM9569122 106264388 c.212A>C p.Q71P Substitution - Missense 38 7:55142409-55142409 + - PATHOGENIC .94041 Confirmed somatic variant 26907767 surgery fresh/frozen primary ENSP00000342376.3:p.Gln71Pro ENST00000342916.7:c.212A>C 7:g.55142409A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 W016-S1 2732510 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 W016-S1 2732510 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51785510 COSM6957413 106239256 c.1102G>A p.D368N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000342376.3:p.Asp368Asn ENST00000342916.7:c.1102G>A 7:g.55156628G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 EXTERN_MELA_20140524_012 2839317 2695083 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51776559 COSM4892884 106242415 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000342376.3:p.Pro100Ser ENST00000342916.7:c.298C>T 7:g.55143362C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 EXTERN_MELA_20140524_012 2839317 2695083 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 106242422 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000342376.3:p.Ser116Phe ENST00000342916.7:c.347C>T 7:g.55143411C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 YUFARCI 2013606 1896238 skin NS NS NS malignant_melanoma NS NS NS y COSV51816429 COSM1698693 106246147 c.1810A>G p.N604D Substitution - Missense het 38 7:55165367-55165367 + - NEUTRAL .4812 Confirmed somatic variant 22842228 NS NS ENSP00000342376.3:p.Asn604Asp ENST00000342916.7:c.1810A>G 7:g.55165367A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006363-T01-IM5 2722740 2581561 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006363-T01-IM5 2722740 2581561 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 106240722 c.866C>A p.A289D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Ala289Asp ENST00000342916.7:c.866C>A 7:g.55154129C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-YG-AA3N-01 2339750 2204733 skin NS NS NS malignant_melanoma NS NS NS y COSV51794869 COSM4362780 106240452 c.574C>T p.P192S Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 540 NS primary 67 ENSP00000342376.3:p.Pro192Ser ENST00000342916.7:c.574C>T 7:g.55151308C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0002022-T01-IM3 2718329 2577150 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 106242169 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg252Cys ENST00000342916.7:c.754C>T 7:g.55154017C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2696712 2696712 2555616 oesophagus NS NS NS other metaplasia epidermoid NS n COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28731047 surgery-fixed primary 65 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PT36 2521293 2383636 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV51784241 COSM5915646 106255900 c.1190C>T p.T397I Substitution - Missense 38 7:55156815-55156815 + - PATHOGENIC .99038 Confirmed somatic variant 25759019 surgery fresh/frozen NS ENSP00000342376.3:p.Thr397Ile ENST00000342916.7:c.1190C>T 7:g.55156815C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 16 2630307 2490691 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51780760 COSM6196858 106251362 c.341A>G p.E114G Substitution - Missense 38 7:55143405-55143405 + - PATHOGENIC .99844 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000342376.3:p.Glu114Gly ENST00000342916.7:c.341A>G 7:g.55143405A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-12-0691-01 2178100 2046398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774829 COSM1451549 106240536 c.767A>G p.D256G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 329 NS NS 63 ENSP00000342376.3:p.Asp256Gly ENST00000342916.7:c.767A>G 7:g.55154030A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006368-T01-IM5 2722745 2581566 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51843325 COSM6950386 106254777 c.1102G>T p.D368Y Substitution - Missense het 38 7:55156628-55156628 + - PATHOGENIC .97349 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Asp368Tyr ENST00000342916.7:c.1102G>T 7:g.55156628G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-BB-8596-01 2193542 2061820 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99289667 COSM8311578 106256369 c.1507G>A p.G503S Substitution - Missense 38 7:55161507-55161507 + - NEUTRAL .07845 Confirmed somatic variant 627 NS NS 69 ENSP00000342376.3:p.Gly503Ser ENST00000342916.7:c.1507G>A 7:g.55161507G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0155 2107953 1985814 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 106241217 c.910C>T p.H304Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.His304Tyr ENST00000342916.7:c.910C>T 7:g.55155850C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0002105-T01-IM3 2718403 2577224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51844520 COSM6920741 106251133 c.639C>G p.I213M Substitution - Missense het 38 7:55152556-55152556 + - PATHOGENIC .89498 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Ile213Met ENST00000342916.7:c.639C>G 7:g.55152556C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 C086 2465276 2328109 NS NS NS NS malignant_melanoma NS NS NS y COSV51845994 COSM5530405 106239506 c.1633G>A p.E545K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 23890154 cell-line metastasis ENSP00000342376.3:p.Glu545Lys ENST00000342916.7:c.1633G>A 7:g.55163734G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0000378-T01-IM3 2715158 2573979 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 106247656 c.1793G>C p.G598A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Gly598Ala ENST00000342916.7:c.1793G>C 7:g.55165350G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0000378-T01-IM3 2715158 2573979 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849115 COSM6910123 106249255 c.715G>T p.G239C Substitution - Missense het 38 7:55152632-55152632 + - PATHOGENIC .99578 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Gly239Cys ENST00000342916.7:c.715G>T 7:g.55152632G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2014_Lung_sq_14_T 2744885 2603588 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 58 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006758-T01-IM5 2723137 2581958 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51797815 COSM6953729 106254340 c.1867A>C p.N623H Substitution - Missense het 38 7:55165424-55165424 + - PATHOGENIC .99714 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Asn623His ENST00000342916.7:c.1867A>C 7:g.55165424A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S001103 1027689 944665 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 106241473 c.787A>C p.T263P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Thr263Pro ENST00000342916.7:c.787A>C 7:g.55154050A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 J11 2815385 2671765 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 29263181 surgery fresh/frozen NS 50 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PDA_074 2367415 2230253 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV51828052 COSM5002066 106264557 c.514T>C p.F172L Substitution - Missense 38 7:55146695-55146695 + - NEUTRAL .04786 Confirmed somatic variant 25855536 NS NS ENSP00000342376.3:p.Phe172Leu ENST00000342916.7:c.514T>C 7:g.55146695T>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0008601-T01-IM5 2724703 2583524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 DCG_04 2664382 2524436 central_nervous_system cerebellum NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51838314 COSM6837033 106242941 c.1486G>A p.E496K Substitution - Missense 38 7:55160326-55160326 + - NEUTRAL .08736 Confirmed somatic variant 28852847 surgery fresh/frozen NS 40 ENSP00000342376.3:p.Glu496Lys ENST00000342916.7:c.1486G>A 7:g.55160326G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-32-1979-01 2120345 1994581 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 106241525 c.809A>G p.Y270C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 329 NS NS 69 ENSP00000342376.3:p.Tyr270Cys ENST00000342916.7:c.809A>G 7:g.55154072A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S001050 1027681 944657 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51835541 COSM21682 106257332 c.187G>C p.G63R Substitution - Missense het 38 7:55142384-55142384 + - PATHOGENIC .9897 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Gly63Arg ENST00000342916.7:c.187G>C 7:g.55142384G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S001050 1027681 944657 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51835525 COSM21681 106257326 c.136G>A p.D46N Substitution - Missense het 38 7:55142333-55142333 + - PATHOGENIC .94315 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Asp46Asn ENST00000342916.7:c.136G>A 7:g.55142333G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CSCC-7-T 2292460 2158524 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51852113 COSM4501266 106247110 c.584C>T p.P195L Substitution - Missense het 38 7:55151318-55151318 + - NEUTRAL .31382 Confirmed somatic variant 25303977 surgery fresh/frozen primary 60 ENSP00000342376.3:p.Pro195Leu ENST00000342916.7:c.584C>T 7:g.55151318C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0008179-T01-IM5 2830114 2685929 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 106242313 c.1774G>A p.V592I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000342376.3:p.Val592Ile ENST00000342916.7:c.1774G>A 7:g.55165331G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-12-0619-01 1909590 1798111 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 fresh/frozen - NOS primary 60 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 B105-0 2097254 1975318 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV51776529 COSM1755314 106260223 c.1880G>A p.G627E Substitution - Missense 38 7:55165437-55165437 + - PATHOGENIC .99581 Confirmed somatic variant 24121792 fresh/frozen - NOS NS ENSP00000342376.3:p.Gly627Glu ENST00000342916.7:c.1880G>A 7:g.55165437G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MB-T29 2802988 2659798 breast NS NS NS carcinoma ER-PR-positive_carcinoma NS NS n COSV51836185 COSM4884832 106253273 c.739G>T p.D247Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 26960396 fixed - NOS NS 83 ENSP00000342376.3:p.Asp247Tyr ENST00000342916.7:c.739G>T 7:g.55152656G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-14-1456-01 1338007 1248392 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 23 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0001193-T01-IM3 2716798 2575619 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV51852240 COSM6915314 106241860 c.332T>C p.M111T Substitution - Missense het 38 7:55143396-55143396 + - PATHOGENIC .8651 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Met111Thr ENST00000342916.7:c.332T>C 7:g.55143396T>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0008777-T01-IM5 2724826 2583647 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-92-6393-Tumor-SM-7CKB6 2640208 2500509 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma NS NS y COSV51802220 COSM6458155 106240027 c.940G>A p.D314N Substitution - Missense 38 7:55155880-55155880 + - PATHOGENIC .94623 Confirmed somatic variant 28098136 surgery-fixed primary 65 ENSP00000342376.3:p.Asp314Asn ENST00000342916.7:c.940G>A 7:g.55155880G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-27-1838-01 1338063 1248448 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 106240722 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000342376.3:p.Ala289Asp ENST00000342916.7:c.866C>A 7:g.55154129C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-1804-01 2120260 1994496 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51855357 COSM3412180 106257532 c.766G>T p.D256Y Substitution - Missense 38 7:55154029-55154029 + - PATHOGENIC .9742 Confirmed somatic variant 329 NS NS 81 ENSP00000342376.3:p.Asp256Tyr ENST00000342916.7:c.766G>T 7:g.55154029G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-14-0790-01 1337989 1248374 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 64 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-VQ-A8PX-01 2339506 2204489 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99285314 COSM8202780 106252803 c.671G>A p.R224H Substitution - Missense 38 7:55152588-55152588 + - PATHOGENIC .91275 Confirmed somatic variant 541 NS primary 51 ENSP00000342376.3:p.Arg224His ENST00000342916.7:c.671G>A 7:g.55152588G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV51830890 COSM3639718 106255151 c.303G>T p.L101F Substitution - Missense 38 7:55143367-55143367 + - PATHOGENIC .93362 Confirmed somatic variant 540 NS NS 37 ENSP00000342376.3:p.Leu101Phe ENST00000342916.7:c.303G>T 7:g.55143367G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0001124-T01-IM3 2716673 2575494 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51781531 COSM6914964 106248974 c.650A>T p.Q217L Substitution - Missense het 38 7:55152567-55152567 + - PATHOGENIC .9889 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Gln217Leu ENST00000342916.7:c.650A>T 7:g.55152567A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0007562-T01-IM5 2723848 2582669 soft_tissue fibrous_tissue_and_uncertain_origin NS NS malignant_fibrous_histiocytoma-pleomorphic_sarcoma NS NS NS n COSV51779875 COSM6958517 106263422 c.922G>A p.V308I Substitution - Missense het 38 7:55155862-55155862 + - PATHOGENIC .99324 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Val308Ile ENST00000342916.7:c.922G>A 7:g.55155862G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PD9568a 1649032 1563971 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV51788518 COSM5752712 106250973 c.1786C>G p.P596A Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99615 Confirmed somatic variant 27135926 NS NS ENSP00000342376.3:p.Pro596Ala ENST00000342916.7:c.1786C>G 7:g.55165343C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0008179-T01-IM5 2787021 2644444 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51799199 COSM1251020 106242313 c.1774G>A p.V592I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000342376.3:p.Val592Ile ENST00000342916.7:c.1774G>A 7:g.55165331G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2696516 2696516 2555420 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28201779 surgery fresh/frozen NS 68 ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV99293869 COSM8151148 106255160 c.1108C>A p.H370N Substitution - Missense 38 7:55156634-55156634 + - NEUTRAL .19929 Confirmed somatic variant 540 NS NS 37 ENSP00000342376.3:p.His370Asn ENST00000342916.7:c.1108C>A 7:g.55156634C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GC13 2896794 2751142 placenta NS NS NS choriocarcinoma NS NS NS y COSV105863774 COSM9953649 106243027 c.446G>T p.R149L Substitution - Missense 38 7:55146627-55146627 + - PATHOGENIC .93954 Confirmed somatic variant 33319857 surgery-fixed metastasis 39 ENSP00000342376.3:p.Arg149Leu ENST00000342916.7:c.446G>T 7:g.55146627G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0005929-T01-IM5 2722311 2581132 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-EE-A2MF-06 2339957 2204940 skin NS NS NS malignant_melanoma NS NS NS y COSV51776559 COSM4892884 106242415 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 540 NS NS 39 ENSP00000342376.3:p.Pro100Ser ENST00000342916.7:c.298C>T 7:g.55143362C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-EE-A2MF-06 2339957 2204940 skin NS NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 106242422 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 540 NS NS 39 ENSP00000342376.3:p.Ser116Phe ENST00000342916.7:c.347C>T 7:g.55143411C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 5-WS012-T14 2869947 2724944 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110458 COSM9657212 106263346 c.1451_1452delinsTT p.S484F Substitution - Missense 38 7:55160291-55160292 + - Confirmed somatic variant 26950094 surgery - NOS NS 82 ENSP00000342376.3:p.Ser484Phe ENST00000342916.7:c.1451_1452delinsTT 7:g.55160291_55160292delinsTT EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P122 2072582 1951937 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 55.2 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T3110 2658365 2518524 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51837186 COSM1090861 106245627 c.442G>A p.V148M Substitution - Missense 38 7:55146623-55146623 + - PATHOGENIC .99004 Confirmed somatic variant 27149842 NS NS 60.33 ENSP00000342376.3:p.Val148Met ENST00000342916.7:c.442G>A 7:g.55146623G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-12-0656 2108024 1985885 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 106240722 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Ala289Asp ENST00000342916.7:c.866C>A 7:g.55154129C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 600 2131840 2005904 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51777649 COSM3721610 106257696 c.608G>A p.G203E Substitution - Missense 38 7:55151342-55151342 + - PATHOGENIC .98938 Confirmed somatic variant 23619168 fresh/frozen - NOS NS 57 ENSP00000342376.3:p.Gly203Glu ENST00000342916.7:c.608G>A 7:g.55151342G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-FP-A4BE-01 2197995 2066273 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51785413 COSM1176673 106243142 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 541 NS NS 55 ENSP00000342376.3:p.Arg252His ENST00000342916.7:c.755G>A 7:g.55154018G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-76-6661-01 2120394 1994630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 106241217 c.910C>T p.H304Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 NS NS 54 ENSP00000342376.3:p.His304Tyr ENST00000342916.7:c.910C>T 7:g.55155850C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-76-6661-01 2120394 1994630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51814881 COSM3929116 106249459 c.934G>T p.G312W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 329 NS NS 54 ENSP00000342376.3:p.Gly312Trp ENST00000342916.7:c.934G>T 7:g.55155874G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-CH-5765-01 1797170 1698917 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51795500 COSM1131544 106256608 c.692G>C p.C231S Substitution - Missense 38 7:55152609-55152609 + - PATHOGENIC .99547 Confirmed somatic variant 435 fresh/frozen - NOS primary 55 ENSP00000342376.3:p.Cys231Ser ENST00000342916.7:c.692G>C 7:g.55152609G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 IGC-04-1136 2662303 2522427 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51809481 COSM6530127 106246787 c.991G>C p.G331R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .97571 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000342376.3:p.Gly331Arg ENST00000342916.7:c.991G>C 7:g.55155931G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0000894-T01-IM3 2716206 2575027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51822498 COSM3266565 106254394 c.917C>T p.S306L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Ser306Leu ENST00000342916.7:c.917C>T 7:g.55155857C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-ER-A42L-06 2456271 2319108 skin NS NS NS malignant_melanoma NS NS NS y COSV99287971 COSM7900658 106253426 c.1781C>T p.T594I Substitution - Missense 38 7:55165338-55165338 + - PATHOGENIC .94394 Confirmed somatic variant 540 NS metastasis 49 ENSP00000342376.3:p.Thr594Ile ENST00000342916.7:c.1781C>T 7:g.55165338C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-12-0691 2108027 1985888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774829 COSM1451549 106240536 c.767A>G p.D256G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Asp256Gly ENST00000342916.7:c.767A>G 7:g.55154030A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006622-T01-IM5 2786996 2644419 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51845994 COSM5530405 106239506 c.1633G>A p.E545K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000342376.3:p.Glu545Lys ENST00000342916.7:c.1633G>A 7:g.55163734G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194733 1194733 1106628 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 SDC7 2564876 2426270 salivary_gland NS NS NS carcinoma salivary_duct_carcinoma NS NS y COSV51792147 COSM5988249 106251750 c.1170G>T p.Q390H Substitution - Missense 38 7:55156795-55156795 + - NEUTRAL .3446 Confirmed somatic variant 27103403 surgery fresh/frozen recurrent ENSP00000342376.3:p.Gln390His ENST00000342916.7:c.1170G>T 7:g.55156795G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 Thyroid-CN-WZ037T 2635098 2495494 thyroid NS NS NS carcinoma NS NS NS y COSV51794993 COSM6399094 106247891 c.5G>A p.R2Q Substitution - Missense 38 7:55019282-55019282 + - NEUTRAL .46409 Confirmed somatic variant 676 NS primary 40 ENSP00000342376.3:p.Arg2Gln ENST00000342916.7:c.5G>A 7:g.55019282G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 Br20P 1312980 1223889 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51815967 COSM39522 106240671 c.655T>G p.C219G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 18772396 surgery - NOS primary 77 ENSP00000342376.3:p.Cys219Gly ENST00000342916.7:c.655T>G 7:g.55152572T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009587-T01-IM5 2725481 2584302 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009587-T01-IM5 2725481 2584302 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 ESCC_BICR_010T 2456865 2319702 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51822386 COSM5436048 106262200 c.1574C>G p.S525C Substitution - Missense 38 7:55161574-55161574 + - PATHOGENIC .96861 Confirmed somatic variant 582 NS primary 70 ENSP00000342376.3:p.Ser525Cys ENST00000342916.7:c.1574C>G 7:g.55161574C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 EX01M 2653306 2513433 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS metastasis 58.5 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CRC104post 2730749 2589518 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV104577027 COSM9413135 106247580 c.1394G>A p.G465E Substitution - Missense 38 7:55160234-55160234 + - NEUTRAL .11765 Confirmed somatic variant 26416732 xenograft metastasis 62 ENSP00000342376.3:p.Gly465Glu ENST00000342916.7:c.1394G>A 7:g.55160234G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0743-01 1337857 1248242 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 69 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0743-01 1337857 1248242 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51853321 COSM3412170 106254910 c.478G>A p.E160K Substitution - Missense 38 7:55146659-55146659 + - PATHOGENIC .9774 Confirmed somatic variant 329 surgery fresh/frozen NS 69 ENSP00000342376.3:p.Glu160Lys ENST00000342916.7:c.478G>A 7:g.55146659G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0002647-T01-IM3 2718893 2577714 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0881-01 1337868 1248253 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-14-1395-01 2120295 1994531 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51827895 COSM3412174 106241589 c.685A>T p.S229C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 329 NS NS 52 ENSP00000342376.3:p.Ser229Cys ENST00000342916.7:c.685A>T 7:g.55152602A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2876622 2876622 2731137 lung NS NS NS carcinoma NS NS NS n COSV51785510 COSM6957413 106239256 c.1102G>A p.D368N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 29506987 circulating tumour NS 51 ENSP00000342376.3:p.Asp368Asn ENST00000342916.7:c.1102G>A 7:g.55156628G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T2946 2658354 2518513 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777851 COSM1205052 106248087 c.494G>A p.R165Q Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .0375 Confirmed somatic variant 27149842 NS NS 78.66 ENSP00000342376.3:p.Arg165Gln ENST00000342916.7:c.494G>A 7:g.55146675G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T3022 2658418 2518577 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51770269 COSM5710629 106254436 c.1015G>A p.G339R Substitution - Missense 38 7:55156541-55156541 + - PATHOGENIC .9949 Confirmed somatic variant 27149842 NS NS 74.83 ENSP00000342376.3:p.Gly339Arg ENST00000342916.7:c.1015G>A 7:g.55156541G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-E1-A7Z2-01 2457427 2320264 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 58 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0011383-T01-IM5 2726979 2585800 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 IGC-01-1037 2662275 2522399 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51838271 COSM6515024 106240897 c.125G>A p.G42D Substitution - Missense 38 7:55142322-55142322 + - PATHOGENIC .98106 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000342376.3:p.Gly42Asp ENST00000342916.7:c.125G>A 7:g.55142322G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-19-1388-01 2178164 2046462 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289486 COSM7485141 106262862 c.1824G>C p.W608C Substitution - Missense 38 7:55165381-55165381 + - PATHOGENIC .98435 Confirmed somatic variant 329 NS NS 58 ENSP00000342376.3:p.Trp608Cys ENST00000342916.7:c.1824G>C 7:g.55165381G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0002294-T02-IM5 2719498 2578319 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51817765 COSM6959438 106243517 c.1802G>A p.G601E Substitution - Missense het 38 7:55165359-55165359 + - PATHOGENIC .9907 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Gly601Glu ENST00000342916.7:c.1802G>A 7:g.55165359G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-97-8172-01 2194801 2063079 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51850921 COSM5982763 106246217 c.1879G>T p.G627W Substitution - Missense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 417 NS NS 75 ENSP00000342376.3:p.Gly627Trp ENST00000342916.7:c.1879G>T 7:g.55165436G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783348 COSM6196859 106247877 c.380C>T p.A127V Substitution - Missense 38 7:55143444-55143444 + - NEUTRAL .27751 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000342376.3:p.Ala127Val ENST00000342916.7:c.380C>T 7:g.55143444C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783354 COSM6196860 106247882 c.415A>G p.N139D Substitution - Missense 38 7:55143479-55143479 + - PATHOGENIC .81387 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000342376.3:p.Asn139Asp ENST00000342916.7:c.415A>G 7:g.55143479A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009830-T01-IM5 2725668 2584489 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 106243142 c.755G>A p.R252H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Arg252His ENST00000342916.7:c.755G>A 7:g.55154018G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006622-T01-IM5 2723002 2581823 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51845994 COSM5530405 106239506 c.1633G>A p.E545K Substitution - Missense het 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Glu545Lys ENST00000342916.7:c.1633G>A 7:g.55163734G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-CV-7103-01 2193635 2061913 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99291703 COSM8371626 106255196 c.112C>G p.L38V Substitution - Missense 38 7:55142309-55142309 + - PATHOGENIC .94561 Confirmed somatic variant 627 NS NS 49 ENSP00000342376.3:p.Leu38Val ENST00000342916.7:c.112C>G 7:g.55142309C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 Pat_41_B 2513797 2376166 NS NS NS NS malignant_melanoma NS NS NS y COSV51772860 COSM5872872 106255226 c.683C>T p.P228L Substitution - Missense 38 7:55152600-55152600 + - PATHOGENIC .99115 Confirmed somatic variant 24265153 surgery-fixed NS 76 ENSP00000342376.3:p.Pro228Leu ENST00000342916.7:c.683C>T 7:g.55152600C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003702-T02-IM5 2720190 2579011 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51831642 COSM1496684 106245349 c.988G>A p.E330K Substitution - Missense het 38 7:55155928-55155928 + - PATHOGENIC .94538 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Glu330Lys ENST00000342916.7:c.988G>A 7:g.55155928G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GBM15 2144555 2013769 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 24285547 surgery fresh/frozen primary 73 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MaPT05 2491636 2354277 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51771223 COSM3929114 106242577 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000342376.3:p.Glu84Val ENST00000342916.7:c.251A>T 7:g.55143315A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV99294040 COSM9120802 106247209 c.379G>A p.A127T Substitution - Missense het 38 7:55143443-55143443 + - NEUTRAL .01752 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000342376.3:p.Ala127Thr ENST00000342916.7:c.379G>A 7:g.55143443G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV104368998 COSM9232920 106247232 c.886C>T p.P296S Substitution - Missense het 38 7:55154149-55154149 + - PATHOGENIC .98876 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000342376.3:p.Pro296Ser ENST00000342916.7:c.886C>T 7:g.55154149C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0001703-T01-IM3 2717826 2576647 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51782832 COSM3881808 106254474 c.739G>A p.D247N Substitution - Missense het 38 7:55152656-55152656 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Asp247Asn ENST00000342916.7:c.739G>A 7:g.55152656G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T2250 2658595 2518754 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51769145 COSM3266559 106255214 c.874G>A p.V292M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 27149842 NS NS 62.08 ENSP00000342376.3:p.Val292Met ENST00000342916.7:c.874G>A 7:g.55154137G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 92177 2807582 2664283 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99293495 COSM9130691 106267154 c.535G>A p.D179N Substitution - Missense 38 7:55146716-55146716 + - PATHOGENIC .99452 Confirmed somatic variant 24807215 surgery fresh/frozen primary 45 ENSP00000342376.3:p.Asp179Asn ENST00000342916.7:c.535G>A 7:g.55146716G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MaPT01s 2491582 2354223 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51775191 COSM1451530 106240644 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000342376.3:p.Gly63Arg ENST00000342916.7:c.187G>A 7:g.55142384G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 I2L-P16-Tumor-Biopsy 2433478 2296359 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51814923 COSM5358036 106242002 c.559T>C p.C187R Substitution - Missense het 38 7:55146740-55146740 + - PATHOGENIC .98691 Confirmed somatic variant 25957691 NS NS 67 ENSP00000342376.3:p.Cys187Arg ENST00000342916.7:c.559T>C 7:g.55146740T>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-14-1456 2108037 1985898 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-5856-01 2120270 1994506 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 58 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-14-1823-01 1338013 1248398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 58 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0125 2107938 1985799 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-76-6656-01 2120392 1994628 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51857475 COSM3412176 106257496 c.719G>A p.C240Y Substitution - Missense 38 7:55152636-55152636 + - PATHOGENIC .99504 Confirmed somatic variant 329 NS NS 66 ENSP00000342376.3:p.Cys240Tyr ENST00000342916.7:c.719G>A 7:g.55152636G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P146 2072599 1951954 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 48 ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DF-A2KN-01 2457388 2320225 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99289848 COSM9047248 106246019 c.1058C>T p.A353V Substitution - Missense 38 7:55156584-55156584 + - PATHOGENIC .99015 Confirmed somatic variant 419 NS primary ENSP00000342376.3:p.Ala353Val ENST00000342916.7:c.1058C>T 7:g.55156584C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-FG-A70Z-01 2194226 2062504 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 53 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-81-5911-01 2120399 1994635 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 33 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0002490-T01-IM3 2718762 2577583 NS NS NS NS malignant_melanoma NS NS NS n COSV51822498 COSM3266565 106254394 c.917C>T p.S306L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Ser306Leu ENST00000342916.7:c.917C>T 7:g.55155857C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0002490-T01-IM3 2718762 2577583 NS NS NS NS malignant_melanoma NS NS NS n COSV51822525 COSM6922832 106255632 c.1340C>T p.S447F Substitution - Missense het 38 7:55160180-55160180 + - .61329 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Ser447Phe ENST00000342916.7:c.1340C>T 7:g.55160180C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0011389-T01-IM5 2726985 2585806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GBM19-I3 2813467 2669859 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T578 2658233 2518392 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51788796 COSM4680390 106250329 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 27149842 NS NS 61.08 ENSP00000342376.3:p.Arg98Gln ENST00000342916.7:c.293G>A 7:g.55143357G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-FG-A4MW-01 2194412 2062690 central_nervous_system brain NS NS glioma NS NS NS y COSV51814881 COSM3929116 106249459 c.934G>T p.G312W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 545 NS NS 63 ENSP00000342376.3:p.Gly312Trp ENST00000342916.7:c.934G>T 7:g.55155874G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PD7043a 1504254 1427132 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia NS n COSV51852469 COSM4384119 106241914 c.1417A>G p.N473D Substitution - Missense 38 7:55160257-55160257 + - NEUTRAL .3314 Confirmed somatic variant 24030381 NS NS ENSP00000342376.3:p.Asn473Asp ENST00000342916.7:c.1417A>G 7:g.55160257A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-02-2466-01 2178184 2046482 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 61 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-BA-4075-01 2193631 2061909 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99292704 COSM8332917 106251604 c.1637C>A p.P546Q Substitution - Missense 38 7:55163738-55163738 + - PATHOGENIC .97378 Confirmed somatic variant 627 NS NS 49 ENSP00000342376.3:p.Pro546Gln ENST00000342916.7:c.1637C>A 7:g.55163738C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 SA213 1659983 1574311 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS y COSV51858303 COSM214296 106260431 c.1159C>G p.L387V Substitution - Missense 38 7:55156784-55156784 + - PATHOGENIC .93843 Confirmed somatic variant 22495314 fresh/frozen - NOS primary 49 ENSP00000342376.3:p.Leu387Val ENST00000342916.7:c.1159C>G 7:g.55156784C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T578 2296255 2161858 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51788796 COSM4680390 106250329 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 25344691 NS NS 61.08 ENSP00000342376.3:p.Arg98Gln ENST00000342916.7:c.293G>A 7:g.55143357G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-28-5207 2108065 1985926 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-28-1749-01 2178174 2046472 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 106245463 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 NS NS 73 ENSP00000342376.3:p.Thr363Ile ENST00000342916.7:c.1088C>T 7:g.55156614C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2665864 2665864 2525572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792237 COSM6842523 106244556 c.829_830delinsGA p.M277E Substitution - Missense het 38 7:55154092-55154093 + - Confirmed somatic variant 28979142 surgery - NOS NS 70 ENSP00000342376.3:p.Met277Glu ENST00000342916.7:c.829_830delinsGA 7:g.55154092_55154093delinsGA EGFR_ENST00000342916 ENST00000342916.7 1887 3236 EXTERN_MELA_20140505_038 2839416 2695182 skin ear NS NS malignant_melanoma NS NS NS y COSV104577055 COSM9446911 106250709 c.887C>T p.P296L Substitution - Missense 38 7:55154150-55154150 + - PATHOGENIC .98876 Confirmed somatic variant 28467829 surgery fresh/frozen recurrent ENSP00000342376.3:p.Pro296Leu ENST00000342916.7:c.887C>T 7:g.55154150C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-WE-AAA4-06 2339475 2204458 skin NS NS NS malignant_melanoma NS NS NS y COSV99286479 COSM8046349 106247849 c.1390T>C p.S464P Substitution - Missense 38 7:55160230-55160230 + - PATHOGENIC .73545 Confirmed somatic variant 540 NS NS 56 ENSP00000342376.3:p.Ser464Pro ENST00000342916.7:c.1390T>C 7:g.55160230T>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0002998-T01-IM3 2719207 2578028 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51805664 COSM6925533 106261406 c.1783T>G p.C595G Substitution - Missense het 38 7:55165340-55165340 + - PATHOGENIC .9957 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Cys595Gly ENST00000342916.7:c.1783T>G 7:g.55165340T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0010340-T01-IM5 2726107 2584928 NS NS NS NS malignant_melanoma NS NS NS n COSV51799199 COSM1251020 106242313 c.1774G>A p.V592I Substitution - Missense het 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Val592Ile ENST00000342916.7:c.1774G>A 7:g.55165331G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009873-T01-IM5 2725712 2584533 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 10677523 2751151 2609847 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV105822270 COSM9522396 106249371 c.1784G>C p.C595S Substitution - Missense 38 7:55165341-55165341 + - Confirmed somatic variant 29748005 circulating tumour NS ENSP00000342376.3:p.Cys595Ser ENST00000342916.7:c.1784G>C 7:g.55165341G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-13-0912-01 1474988 1398687 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51781835 COSM174732 106241611 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 21720365 331 NS primary 58 ENSP00000342376.3:p.Glu114Lys ENST00000342916.7:c.340G>A 7:g.55143404G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-13-0912-01 1474988 1398687 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51781835 COSM174732 106241611 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 331 NS primary 58 ENSP00000342376.3:p.Glu114Lys ENST00000342916.7:c.340G>A 7:g.55143404G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0750 2107989 1985850 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51807036 COSM2151966 106245927 c.1787C>G p.P596R Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99615 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Pro596Arg ENST00000342916.7:c.1787C>G 7:g.55165344C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801711 COSM3923810 106260495 c.907G>A p.D303N Substitution - Missense 38 7:55155847-55155847 + - PATHOGENIC .99324 Confirmed somatic variant 540 NS NS 68 ENSP00000342376.3:p.Asp303Asn ENST00000342916.7:c.907G>A 7:g.55155847G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0749 2107988 1985849 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003783-T01-IM5 2720274 2579095 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 OSCC-GB_00550111 2340760 2205743 upper_aerodigestive_tract mouth NS NS carcinoma NS NS NS y COSV51836185 COSM4884832 106253273 c.739G>T p.D247Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 539 NS primary 58 ENSP00000342376.3:p.Asp247Tyr ENST00000342916.7:c.739G>T 7:g.55152656G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DI-A1BU-01 2198300 2066578 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99287849 COSM8863291 106251011 c.1666A>G p.I556V Substitution - Missense 38 7:55163767-55163767 + - NEUTRAL .09266 Confirmed somatic variant 419 NS NS 55 ENSP00000342376.3:p.Ile556Val ENST00000342916.7:c.1666A>G 7:g.55163767A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 M702PT 2671818 2531377 pleura NS NS NS mesothelioma epithelial NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26928227 surgery fresh/frozen primary 30 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-EY-A2OM-01 2198301 2066579 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99285698 COSM9064376 106245701 c.833A>G p.D278G Substitution - Missense 38 7:55154096-55154096 + - PATHOGENIC .95224 Confirmed somatic variant 419 NS NS 55 ENSP00000342376.3:p.Asp278Gly ENST00000342916.7:c.833A>G 7:g.55154096A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV51778830 COSM1698691 106241516 c.1198G>A p.E400K Substitution - Missense 38 7:55156823-55156823 + - PATHOGENIC .99571 Confirmed somatic variant 540 NS NS 90 ENSP00000342376.3:p.Glu400Lys ENST00000342916.7:c.1198G>A 7:g.55156823G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-14-0866-01 2178121 2046419 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99295486 COSM7482458 106250801 c.1139C>T p.S380F Substitution - Missense 38 7:55156764-55156764 + - NEUTRAL .25937 Confirmed somatic variant 329 NS NS 55 ENSP00000342376.3:p.Ser380Phe ENST00000342916.7:c.1139C>T 7:g.55156764C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0008346-T01-IM5 2724474 2583295 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51838649 COSM6962468 106255948 c.412A>G p.R138G Substitution - Missense het 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg138Gly ENST00000342916.7:c.412A>G 7:g.55143476A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 238 2131812 2005876 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 23619168 fresh/frozen - NOS NS 50 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-14-1034-02 2120293 1994529 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51775191 COSM1451530 106240644 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 329 NS NS 60 ENSP00000342376.3:p.Gly63Arg ENST00000342916.7:c.187G>A 7:g.55142384G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 HUB-02-B2-042 2607096 2466810 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51802097 COSM6047686 106262127 c.299C>A p.P100H Substitution - Missense 38 7:55143363-55143363 + - PATHOGENIC .9585 Confirmed somatic variant 670 organoid culture NS ENSP00000342376.3:p.Pro100His ENST00000342916.7:c.299C>A 7:g.55143363C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-32-1970-01 1338089 1248474 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194732 1194732 1106627 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0004379-T01-IM5 2720790 2579611 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51857819 COSM6935325 106247147 c.1397A>C p.N466T Substitution - Missense het 38 7:55160237-55160237 + - PATHOGENIC .99346 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Asn466Thr ENST00000342916.7:c.1397A>C 7:g.55160237A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 Br112X 1313001 1223910 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 18772396 xenograft primary 48 ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0008215-T01-IM5 2830122 2685937 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51834499 COSM6845063 106240065 c.964G>A p.G322S Substitution - Missense 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 30205045 surgery-fixed primary 58 ENSP00000342376.3:p.Gly322Ser ENST00000342916.7:c.964G>A 7:g.55155904G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 B72-S1 2732506 2591266 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 106245463 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 29244145 surgery fresh/frozen primary 76.6 ENSP00000342376.3:p.Thr363Ile ENST00000342916.7:c.1088C>T 7:g.55156614C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 Br02X 1312964 1223873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 xenograft primary 39 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 5-WS012-T2 2869948 2724945 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110279 COSM9809368 106269602 c.299C>T p.P100L Substitution - Missense 38 7:55143363-55143363 + - PATHOGENIC .96024 Confirmed somatic variant 26950094 surgery - NOS NS 82 ENSP00000342376.3:p.Pro100Leu ENST00000342916.7:c.299C>T 7:g.55143363C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-CV-6961-01 2193755 2062033 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51839851 COSM7340115 106251623 c.1118C>A p.P373Q Substitution - Missense 38 7:55156644-55156644 + - PATHOGENIC .76649 Confirmed somatic variant 627 NS NS 61 ENSP00000342376.3:p.Pro373Gln ENST00000342916.7:c.1118C>A 7:g.55156644C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 W016-S2 2732511 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 R056-I1 2813481 2669873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 42 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-HT-8107-01 2194409 2062687 central_nervous_system brain NS NS glioma NS NS NS y COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 545 NS NS 62 ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S001076 1027683 944659 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 LICA-CN-HCC121T 2634168 2494564 liver NS NS NS other neoplasm NS NS y COSV51825459 COSM122789 106244524 c.1423A>G p.I475V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Confirmed somatic variant 660 NS primary 49 ENSP00000342376.3:p.Ile475Val ENST00000342916.7:c.1423A>G 7:g.55160263A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 EXTERN_MELA_20140924_067 2839387 2695153 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV104577161 COSM9392986 106259774 c.1444G>A p.G482R Substitution - Missense 38 7:55160284-55160284 + - PATHOGENIC .93959 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000342376.3:p.Gly482Arg ENST00000342916.7:c.1444G>A 7:g.55160284G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-27-2528-01 1338071 1248456 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 surgery fresh/frozen NS 62 ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S001094 1027685 944661 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 10677523 2751151 2609847 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV105822269 COSM9522392 106249347 c.1006G>C p.V336L Substitution - Missense 38 7:55155946-55155946 + - Confirmed somatic variant 29748005 circulating tumour NS ENSP00000342376.3:p.Val336Leu ENST00000342916.7:c.1006G>C 7:g.55155946G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MaPT10 2491641 2354282 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0011540-T01-IM5 2727112 2585933 small_intestine ileum NS NS carcinoma adenocarcinoma NS NS n COSV51797215 COSM145360 106244577 c.967G>A p.V323I Substitution - Missense het 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Val323Ile ENST00000342916.7:c.967G>A 7:g.55155907G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DA-A3F3-06 2121581 1995817 skin NS NS NS malignant_melanoma NS NS NS y COSV51816429 COSM1698693 106246147 c.1810A>G p.N604D Substitution - Missense 38 7:55165367-55165367 + - NEUTRAL .4812 Confirmed somatic variant 540 NS NS 52 ENSP00000342376.3:p.Asn604Asp ENST00000342916.7:c.1810A>G 7:g.55165367A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 XHDG25 2306032 2171303 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV51811244 COSM4767521 106241457 c.607G>A p.G203R Substitution - Missense 38 7:55151341-55151341 + - PATHOGENIC .99471 Confirmed somatic variant 24997986 NS NS ENSP00000342376.3:p.Gly203Arg ENST00000342916.7:c.607G>A 7:g.55151341G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PD6511a 1491955 1415113 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_unilineage_dysplasia refractory_anaemia n COSV51792673 COSM4384113 106258204 c.523A>G p.N175D Substitution - Missense 38 7:55146704-55146704 + - PATHOGENIC .986 Confirmed somatic variant 24030381 NS NS ENSP00000342376.3:p.Asn175Asp ENST00000342916.7:c.523A>G 7:g.55146704A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0007084-T02-IM5 2723457 2582278 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51797839 COSM6958991 106255094 c.37G>A p.A13T Substitution - Missense het 38 7:55019314-55019314 + - NEUTRAL .01885 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Ala13Thr ENST00000342916.7:c.37G>A 7:g.55019314G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 618 1630888 1547758 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51797215 COSM145360 106244577 c.967G>A p.V323I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 22158541 blood-bone marrow NS ENSP00000342376.3:p.Val323Ile ENST00000342916.7:c.967G>A 7:g.55155907G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 SJALL040461-D 2824035 2679863 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV104576718 COSM9280424 106245500 c.1592G>A p.R531Q Substitution - Missense 38 7:55161592-55161592 + - PATHOGENIC .99386 Confirmed somatic variant 31697823 blood-bone marrow NS 11.64 ENSP00000342376.3:p.Arg531Gln ENST00000342916.7:c.1592G>A 7:g.55161592G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GYWU_828 2771354 2629545 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51794659 COSM6652247 106250184 c.1720C>T p.R574W Substitution - Missense 38 7:55163821-55163821 + - PATHOGENIC .97962 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000342376.3:p.Arg574Trp ENST00000342916.7:c.1720C>T 7:g.55163821C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 DUMC-05 2748702 2607405 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 29802247 surgery fresh/frozen NS 51 ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 16668 1423695 1333723 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790297 COSM48317 106262537 c.406C>A p.P136T Substitution - Missense het 38 7:55143470-55143470 + - PATHOGENIC .9933 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000342376.3:p.Pro136Thr ENST00000342916.7:c.406C>A 7:g.55143470C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T_CCA_SG_13 2688086 2547068 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV51803429 COSM7002279 106244158 c.1280G>A p.R427H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Confirmed somatic variant 653 NS primary 60 ENSP00000342376.3:p.Arg427His ENST00000342916.7:c.1280G>A 7:g.55157735G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-28-5213-01 2120336 1994572 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 72 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801732 COSM3923812 106260507 c.1091C>T p.S364F Substitution - Missense 38 7:55156617-55156617 + - NEUTRAL .433 Confirmed somatic variant 540 NS NS 68 ENSP00000342376.3:p.Ser364Phe ENST00000342916.7:c.1091C>T 7:g.55156617C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CRC65 2730847 2589616 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV105863705 COSM10062224 106239334 c.193T>G p.L65V Substitution - Missense 38 7:55142390-55142390 + - PATHOGENIC .83273 Confirmed somatic variant 26416732 xenograft metastasis 45 ENSP00000342376.3:p.Leu65Val ENST00000342916.7:c.193T>G 7:g.55142390T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 3101B7_035_T 2390296 2253128 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51811266 COSM5041204 106252887 c.385A>G p.K129E Substitution - Missense 38 7:55143449-55143449 + - PATHOGENIC .9498 Confirmed somatic variant 25159915 NS NS ENSP00000342376.3:p.Lys129Glu ENST00000342916.7:c.385A>G 7:g.55143449A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1690853 1690853 1599120 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 106245623 c.1476C>A p.S492R Substitution - Missense 38 7:55160316-55160316 + - NEUTRAL .35843 Confirmed somatic variant 22270724 surgery - NOS recurrent 52 ENSP00000342376.3:p.Ser492Arg ENST00000342916.7:c.1476C>A 7:g.55160316C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51781835 COSM174732 106241611 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Glu114Lys ENST00000342916.7:c.340G>A 7:g.55143404G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0008179-T01-IM5 2724346 2583167 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 106242313 c.1774G>A p.V592I Substitution - Missense het 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Val592Ile ENST00000342916.7:c.1774G>A 7:g.55165331G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 7T 2473854 2336624 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51797600 COSM5575629 106250312 c.391G>A p.G131R Substitution - Missense 38 7:55143455-55143455 + - PATHOGENIC .99768 Confirmed somatic variant 26489445 fixed - NOS NS ENSP00000342376.3:p.Gly131Arg ENST00000342916.7:c.391G>A 7:g.55143455G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2842026 2842026 2697575 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 106245193 c.1474A>C p.S492R Substitution - Missense 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000342376.3:p.Ser492Arg ENST00000342916.7:c.1474A>C 7:g.55160314A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-28-1752-01 2178270 2046568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 42 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-28-1752-01 2178270 2046568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 42 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0001278-T01-IM3 2716974 2575795 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51844468 COSM6916179 106249586 c.308A>T p.N103I Substitution - Missense het 38 7:55143372-55143372 + - PATHOGENIC .97828 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Asn103Ile ENST00000342916.7:c.308A>T 7:g.55143372A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MSU4-c 2809981 2666643 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV99291971 COSM9172239 106252445 c.1820T>C p.V607A Substitution - Missense 38 7:55165377-55165377 + - PATHOGENIC .99812 Confirmed somatic variant 26336987 surgery fresh/frozen primary 76 ENSP00000342376.3:p.Val607Ala ENST00000342916.7:c.1820T>C 7:g.55165377T>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 Br213T 1313043 1223952 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 surgery - NOS primary 71 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-E5-A2PC-01 1898110 1786794 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51779680 COSM1313184 106252323 c.1151C>G p.T384S Substitution - Missense 38 7:55156776-55156776 + - PATHOGENIC .98418 Confirmed somatic variant 413 fresh/frozen - NOS primary 61 ENSP00000342376.3:p.Thr384Ser ENST00000342916.7:c.1151C>G 7:g.55156776C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0007037-T01-IM5 2830039 2685854 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843415 COSM6955777 106254815 c.1239C>A p.N413K Substitution - Missense 38 7:55157694-55157694 + - PATHOGENIC .97853 Confirmed somatic variant 30205045 surgery-fixed metastasis 57 ENSP00000342376.3:p.Asn413Lys ENST00000342916.7:c.1239C>A 7:g.55157694C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0008179-T02-IM5 2830115 2685930 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 106242313 c.1774G>A p.V592I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000342376.3:p.Val592Ile ENST00000342916.7:c.1774G>A 7:g.55165331G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 Br229T 1313048 1223957 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51848573 COSM39565 106254102 c.931T>A p.C311S Substitution - Missense het 38 7:55155871-55155871 + - PATHOGENIC .98855 Confirmed somatic variant 18772396 surgery - NOS primary 28 ENSP00000342376.3:p.Cys311Ser ENST00000342916.7:c.931T>A 7:g.55155871T>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 DUMC-05 2748702 2607405 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 29802247 surgery fresh/frozen NS 51 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787547 COSM6191455 106240438 c.1126T>C p.F376L Substitution - Missense 38 7:55156652-55156652 + - PATHOGENIC .98052 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000342376.3:p.Phe376Leu ENST00000342916.7:c.1126T>C 7:g.55156652T>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2014_Lung_sq_15_T 2744886 2603589 lung NS NS NS carcinoma NS NS NS y COSV51805367 COSM3950642 106252922 c.1039G>A p.D347N Substitution - Missense 38 7:55156565-55156565 + - PATHOGENIC .82248 Confirmed somatic variant 583 NS primary 72 ENSP00000342376.3:p.Asp347Asn ENST00000342916.7:c.1039G>A 7:g.55156565G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 106241473 c.787A>C p.T263P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Thr263Pro ENST00000342916.7:c.787A>C 7:g.55154050A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CGCRC167 2434467 2297344 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV105863924 COSM10049276 106249191 c.1040A>T p.D347V Substitution - Missense 38 7:55156566-55156566 + - PATHOGENIC .89104 Confirmed somatic variant 26416732 surgery - NOS primary 81 ENSP00000342376.3:p.Asp347Val ENST00000342916.7:c.1040A>T 7:g.55156566A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-25-2404-01 1474989 1398688 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV99292585 COSM7509017 106245768 c.1381G>A p.V461M Substitution - Missense 38 7:55160221-55160221 + - PATHOGENIC .98193 Confirmed somatic variant 331 NS primary 38 ENSP00000342376.3:p.Val461Met ENST00000342916.7:c.1381G>A 7:g.55160221G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-25-2404-01 1474989 1398688 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV99292585 COSM7509017 106245768 c.1381G>A p.V461M Substitution - Missense 38 7:55160221-55160221 + - PATHOGENIC .98193 Confirmed somatic variant 21720365 331 NS primary 38 ENSP00000342376.3:p.Val461Met ENST00000342916.7:c.1381G>A 7:g.55160221G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 SK01600_P 1951898 1838690 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51835132 COSM1600351 106258058 c.977G>C p.C326S Substitution - Missense het 38 7:55155917-55155917 + - PATHOGENIC .99486 Confirmed somatic variant 23441165 surgery - NOS primary 57 ENSP00000342376.3:p.Cys326Ser ENST00000342916.7:c.977G>C 7:g.55155917G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51865345 COSM6970489 106267683 c.1177G>A p.D393N Substitution - Missense het 38 7:55156802-55156802 + - PATHOGENIC .91392 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Asp393Asn ENST00000342916.7:c.1177G>A 7:g.55156802G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-43-A56U-01 2195058 2063336 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99290842 COSM8713904 106265360 c.575C>G p.P192R Substitution - Missense 38 7:55151309-55151309 + - PATHOGENIC .9684 Confirmed somatic variant 418 NS NS 76 ENSP00000342376.3:p.Pro192Arg ENST00000342916.7:c.575C>G 7:g.55151309C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 14_S4 2902121 2756359 autonomic_ganglia NS NS NS neuroblastoma NS NS NS n COSV105863896 COSM9976114 106248465 c.818C>G p.T273S Substitution - Missense 38 7:55154081-55154081 + - PATHOGENIC .94747 Confirmed somatic variant 33381456 circulating tumour primary 7 ENSP00000342376.3:p.Thr273Ser ENST00000342916.7:c.818C>G 7:g.55154081C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0007037-T01-IM5 2723412 2582233 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843415 COSM6955777 106254815 c.1239C>A p.N413K Substitution - Missense het 38 7:55157694-55157694 + - PATHOGENIC .97853 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Asn413Lys ENST00000342916.7:c.1239C>A 7:g.55157694C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 EXTERN_MELA_20140924_001 2839320 2695086 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51781835 COSM174732 106241611 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28467829 cell-line metastasis ENSP00000342376.3:p.Glu114Lys ENST00000342916.7:c.340G>A 7:g.55143404G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DU-A7TD-01 2339610 2204593 central_nervous_system brain NS NS glioma NS NS NS y COSV99294781 COSM8258176 106261214 c.827A>T p.Q276L Substitution - Missense 38 7:55154090-55154090 + - PATHOGENIC .97144 Confirmed somatic variant 545 NS primary 52 ENSP00000342376.3:p.Gln276Leu ENST00000342916.7:c.827A>T 7:g.55154090A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0002999-T01-IM3 2783044 2640827 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 106243142 c.755G>A p.R252H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28825054 surgery-fixed primary 57 ENSP00000342376.3:p.Arg252His ENST00000342916.7:c.755G>A 7:g.55154018G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 OSCC-GB_00130111 2121052 1995288 upper_aerodigestive_tract mouth NS NS carcinoma NS NS NS y COSV51815394 COSM3715755 106243702 c.738C>A p.S246R Substitution - Missense 38 7:55152655-55152655 + - NEUTRAL .15461 Confirmed somatic variant 539 NS NS ENSP00000342376.3:p.Ser246Arg ENST00000342916.7:c.738C>A 7:g.55152655C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0142-01 2120247 1994483 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 81 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-02-2485-01 1337809 1248194 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 106240722 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 NS NS 53 ENSP00000342376.3:p.Ala289Asp ENST00000342916.7:c.866C>A 7:g.55154129C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0876 2107991 1985852 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0010610-T01-IM5 2726309 2585130 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51839766 COSM6975560 106242560 c.1864C>G p.P622A Substitution - Missense het 38 7:55165421-55165421 + - NEUTRAL .24318 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Pro622Ala ENST00000342916.7:c.1864C>G 7:g.55165421C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0007319-T01-IM5 2723658 2582479 penis NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51785510 COSM6957413 106239256 c.1102G>A p.D368N Substitution - Missense het 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Asp368Asn ENST00000342916.7:c.1102G>A 7:g.55156628G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0007897-T01-IM5 2724108 2582929 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194726 1194726 1106621 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-BR-8680-01 2197966 2066244 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51785413 COSM1176673 106243142 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 541 NS NS 45 ENSP00000342376.3:p.Arg252His ENST00000342916.7:c.755G>A 7:g.55154018G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PD6313a 1483843 1407469 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_ringed_sideroblasts NS n COSV51819755 COSM4384123 106267942 c.1601A>C p.E534A Substitution - Missense 38 7:55161601-55161601 + - PATHOGENIC .82008 Confirmed somatic variant 24030381 NS NS ENSP00000342376.3:p.Glu534Ala ENST00000342916.7:c.1601A>C 7:g.55161601A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 R056-I1 2813481 2669873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289246 COSM8268187 106241264 c.788C>T p.T263I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 28263318 surgery fresh/frozen NS 42 ENSP00000342376.3:p.Thr263Ile ENST00000342916.7:c.788C>T 7:g.55154051C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 EXTERN_MELA_20140924_131 2839485 2695251 skin scalp NS NS malignant_melanoma NS NS NS y COSV104576577 COSM9396332 106246290 c.1391C>T p.S464L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000342376.3:p.Ser464Leu ENST00000342916.7:c.1391C>T 7:g.55160231C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-19-5956-01 2178192 2046490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99292946 COSM7469776 106260573 c.461C>A p.P154H Substitution - Missense 38 7:55146642-55146642 + - PATHOGENIC .80234 Confirmed somatic variant 329 NS NS 53 ENSP00000342376.3:p.Pro154His ENST00000342916.7:c.461C>A 7:g.55146642C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0155-01 1337821 1248206 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 106241217 c.910C>T p.H304Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 surgery fresh/frozen NS 61 ENSP00000342376.3:p.His304Tyr ENST00000342916.7:c.910C>T 7:g.55155850C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T1849 2658271 2518430 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51794659 COSM6652247 106250184 c.1720C>T p.R574W Substitution - Missense 38 7:55163821-55163821 + - PATHOGENIC .97962 Confirmed somatic variant 27149842 NS NS 79.25 ENSP00000342376.3:p.Arg574Trp ENST00000342916.7:c.1720C>T 7:g.55163821C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51865283 COSM6970485 106267623 c.188G>A p.G63E Substitution - Missense het 38 7:55142385-55142385 + - PATHOGENIC .95671 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Gly63Glu ENST00000342916.7:c.188G>A 7:g.55142385G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 Br124X 1313013 1223922 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 xenograft primary 44 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-BR-6452-01 2197940 2066218 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51804028 COSM3881820 106244932 c.1507G>T p.G503C Substitution - Missense 38 7:55161507-55161507 + - NEUTRAL .38516 Confirmed somatic variant 541 NS NS 78 ENSP00000342376.3:p.Gly503Cys ENST00000342916.7:c.1507G>T 7:g.55161507G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787534 COSM6191454 106240431 c.1075T>C p.F359L Substitution - Missense 38 7:55156601-55156601 + - PATHOGENIC .99231 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000342376.3:p.Phe359Leu ENST00000342916.7:c.1075T>C 7:g.55156601T>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-BB-A5HY-01 2385721 2248553 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99289265 COSM8389919 106266180 c.1255G>C p.A419P Substitution - Missense 38 7:55157710-55157710 + - PATHOGENIC .9183 Confirmed somatic variant 627 NS primary 64 ENSP00000342376.3:p.Ala419Pro ENST00000342916.7:c.1255G>C 7:g.55157710G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T1849 2658271 2518430 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51794620 COSM6652251 106260341 c.46G>A p.A16T Substitution - Missense 38 7:55019323-55019323 + - NEUTRAL .21777 Confirmed somatic variant 27149842 NS NS 79.25 ENSP00000342376.3:p.Ala16Thr ENST00000342916.7:c.46G>A 7:g.55019323G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-KK-A59Y-01 2340238 2205221 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51814881 COSM3929116 106249459 c.934G>T p.G312W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 435 NS primary 56 ENSP00000342376.3:p.Gly312Trp ENST00000342916.7:c.934G>T 7:g.55155874G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003108-T01-IM5 2719604 2578425 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51866279 COSM6926300 106241241 c.665G>A p.R222H Substitution - Missense het 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000342376.3:p.Arg222His ENST00000342916.7:c.665G>A 7:g.55152582G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CHG-100T 2634282 2494678 liver NS NS NS other neoplasm NS NS y COSV51842976 COSM6287773 106239480 c.1352G>A p.R451H Substitution - Missense 38 7:55160192-55160192 + - PATHOGENIC .98594 Confirmed somatic variant 660 NS primary 65 ENSP00000342376.3:p.Arg451His ENST00000342916.7:c.1352G>A 7:g.55160192G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DK-AA75-01 2385754 2248586 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51771467 COSM7104388 106246882 c.1077C>A p.F359L Substitution - Missense 38 7:55156603-55156603 + - PATHOGENIC .96682 Confirmed somatic variant 413 NS primary 82 ENSP00000342376.3:p.Phe359Leu ENST00000342916.7:c.1077C>A 7:g.55156603C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MELA_34952 2760718 2619251 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV51785510 COSM6957413 106239256 c.1102G>A p.D368N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 30178487 surgery fresh/frozen metastasis 25 ENSP00000342376.3:p.Asp368Asn ENST00000342916.7:c.1102G>A 7:g.55156628G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0007381-T01-IM5 2723717 2582538 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51814979 COSM6957934 106255390 c.1335A>G p.I445M Substitution - Missense het 38 7:55160175-55160175 + - NEUTRAL .42702 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Ile445Met ENST00000342916.7:c.1335A>G 7:g.55160175A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 Br215T 1313044 1223953 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51785554 COSM21688 106239985 c.971G>T p.R324L Substitution - Missense het 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 18772396 surgery - NOS primary 50 ENSP00000342376.3:p.Arg324Leu ENST00000342916.7:c.971G>T 7:g.55155911G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006441-T01-IM5 2722817 2581638 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51775191 COSM1451530 106240644 c.187G>A p.G63R Substitution - Missense het 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Gly63Arg ENST00000342916.7:c.187G>A 7:g.55142384G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 EX01T 2653305 2513432 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS primary 58.5 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006612-T01-IM5 2722991 2581812 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51843352 COSM6950555 106254796 c.530C>T p.S177L Substitution - Missense het 38 7:55146711-55146711 + - NEUTRAL .28714 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ser177Leu ENST00000342916.7:c.530C>T 7:g.55146711C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006124-T01-IM5 2722503 2581324 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51842040 COSM6948138 106255919 c.1077C>G p.F359L Substitution - Missense het 38 7:55156603-55156603 + - PATHOGENIC .96894 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Phe359Leu ENST00000342916.7:c.1077C>G 7:g.55156603C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DU-7006-01 2194244 2062522 central_nervous_system brain NS NS glioma NS NS NS y COSV51800797 COSM3412178 106244249 c.755G>C p.R252P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 545 NS NS 60 ENSP00000342376.3:p.Arg252Pro ENST00000342916.7:c.755G>C 7:g.55154018G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0008215-T01-IM5 2724369 2583190 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51834499 COSM6845063 106240065 c.964G>A p.G322S Substitution - Missense het 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Gly322Ser ENST00000342916.7:c.964G>A 7:g.55155904G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0005725-T01-IM5 2722109 2580930 NS NS NS NS malignant_melanoma NS NS NS n COSV51776559 COSM4892884 106242415 c.298C>T p.P100S Substitution - Missense het 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000342376.3:p.Pro100Ser ENST00000342916.7:c.298C>T 7:g.55143362C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787557 COSM6191456 106240443 c.1337C>T p.T446I Substitution - Missense 38 7:55160177-55160177 + - NEUTRAL .13103 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000342376.3:p.Thr446Ile ENST00000342916.7:c.1337C>T 7:g.55160177C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 J80_T 2194988 2063266 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51805367 COSM3950642 106252922 c.1039G>A p.D347N Substitution - Missense 38 7:55156565-55156565 + - PATHOGENIC .82248 Confirmed somatic variant 583 NS NS ENSP00000342376.3:p.Asp347Asn ENST00000342916.7:c.1039G>A 7:g.55156565G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0876 2107991 1985852 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-FG-A4MU-01 2194395 2062673 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 58 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2697837 2697837 2556741 breast NS NS NS carcinoma NS NS NS n COSV51811430 COSM6906106 106265673 c.1265A>G p.N422S Substitution - Missense 38 7:55157720-55157720 + - PATHOGENIC .99784 Confirmed somatic variant 29349598 NS NS ENSP00000342376.3:p.Asn422Ser ENST00000342916.7:c.1265A>G 7:g.55157720A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-2567-01 1337886 1248271 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51816377 COSM3412194 106239772 c.1786C>T p.P596S Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99531 Confirmed somatic variant 329 surgery fresh/frozen NS 65 ENSP00000342376.3:p.Pro596Ser ENST00000342916.7:c.1786C>T 7:g.55165343C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003679-T01-IM5 2720169 2578990 stomach gastroesophageal_junction NS NS carcinoma adenocarcinoma NS NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-2557-01 1337877 1248262 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 76 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-32-1982-01 1338091 1248476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 76 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0174-01 1910190 1798481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51773690 COSM3412198 106264766 c.1841G>A p.G614D Substitution - Missense 38 7:55165398-55165398 + - NEUTRAL .00947 Confirmed somatic variant 329 fresh/frozen - NOS primary 54 ENSP00000342376.3:p.Gly614Asp ENST00000342916.7:c.1841G>A 7:g.55165398G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 LICA-CN-HCC055T 2634102 2494498 liver NS NS NS other neoplasm NS NS y COSV51829036 COSM5823994 106250586 c.1001G>C p.R334P Substitution - Missense 38 7:55155941-55155941 + - PATHOGENIC .84442 Confirmed somatic variant 660 NS primary 65 ENSP00000342376.3:p.Arg334Pro ENST00000342916.7:c.1001G>C 7:g.55155941G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-D3-A8GC-06 2262878 2129862 skin NS NS NS malignant_melanoma NS NS NS y COSV51822525 COSM6922832 106255632 c.1340C>T p.S447F Substitution - Missense 38 7:55160180-55160180 + - .61329 Confirmed somatic variant 540 NS NS 48 ENSP00000342376.3:p.Ser447Phe ENST00000342916.7:c.1340C>T 7:g.55160180C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DU-A5TT-01 2194423 2062701 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 70 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-14-1455-01 2178074 2046372 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 106245463 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 NS NS 61 ENSP00000342376.3:p.Thr363Ile ENST00000342916.7:c.1088C>T 7:g.55156614C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 SC-her2-051 2313868 2179064 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51850832 COSM4943273 106268228 c.840C>A p.N280K Substitution - Missense 38 7:55154103-55154103 + - PATHOGENIC .93631 Confirmed somatic variant 24185512 surgery fresh/frozen metastasis ENSP00000342376.3:p.Asn280Lys ENST00000342916.7:c.840C>A 7:g.55154103C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0004400-T01-IM5 2720811 2579632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0002659-T01-IM3 2718905 2577726 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51775381 COSM6923532 106258784 c.1049C>G p.S350C Substitution - Missense het 38 7:55156575-55156575 + - PATHOGENIC .99062 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Ser350Cys ENST00000342916.7:c.1049C>G 7:g.55156575C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0174-01 1910190 1798481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 fresh/frozen - NOS primary 54 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0004944-T02-IM5 2721354 2580175 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843300 COSM6949613 106254762 c.937G>T p.A313S Substitution - Missense het 38 7:55155877-55155877 + - NEUTRAL .06397 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000342376.3:p.Ala313Ser ENST00000342916.7:c.937G>T 7:g.55155877G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-14-1829-01 1338016 1248401 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 106245463 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 surgery fresh/frozen NS 57 ENSP00000342376.3:p.Thr363Ile ENST00000342916.7:c.1088C>T 7:g.55156614C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0007504-T01-IM5 2723789 2582610 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0011226-T01-IM5 2726843 2585664 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51842174 COSM6979569 106243905 c.1610A>T p.D537V Substitution - Missense het 38 7:55161610-55161610 + - PATHOGENIC .78722 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Asp537Val ENST00000342916.7:c.1610A>T 7:g.55161610A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2492703 2492703 2355318 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 106250485 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000342376.3:p.His47Tyr ENST00000342916.7:c.139C>T 7:g.55142336C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 Br140X 1313029 1223938 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 xenograft primary 41 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P147 2072600 1951955 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 44 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-28-5207-01 2120332 1994568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 71 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006713-T01-IM5 2723092 2581913 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51784387 COSM6953025 106265675 c.70G>T p.A24S Substitution - Missense het 38 7:55019347-55019347 + - NEUTRAL .37583 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Ala24Ser ENST00000342916.7:c.70G>T 7:g.55019347G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 B105-0-Tumor 2185749 2054046 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51776529 COSM1755314 106260223 c.1880G>A p.G627E Substitution - Missense 38 7:55165437-55165437 + - PATHOGENIC .99581 Confirmed somatic variant 581 NS NS ENSP00000342376.3:p.Gly627Glu ENST00000342916.7:c.1880G>A 7:g.55165437G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009459-T01-IM5 2725386 2584207 testis NS NS NS germ_cell_tumour mixed NS NS n COSV51822613 COSM6968786 106245398 c.92G>T p.C31F Substitution - Missense het 38 7:55142289-55142289 + - PATHOGENIC .99814 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Cys31Phe ENST00000342916.7:c.92G>T 7:g.55142289G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0004400-T01-IM5 2720811 2579632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-76-6282-01 2120389 1994625 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51810174 COSM3412190 106242888 c.1712G>C p.C571S Substitution - Missense 38 7:55163813-55163813 + - PATHOGENIC .99637 Confirmed somatic variant 329 NS NS 63 ENSP00000342376.3:p.Cys571Ser ENST00000342916.7:c.1712G>C 7:g.55163813G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 019T 2067099 1946896 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51840438 COSM1727959 106248260 c.374A>G p.Y125C Substitution - Missense 38 7:55143438-55143438 + - PATHOGENIC .99088 Confirmed somatic variant 23788652 surgery - NOS primary ENSP00000342376.3:p.Tyr125Cys ENST00000342916.7:c.374A>G 7:g.55143438A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 SJHYPO052-R 2590153 2451283 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 106242402 c.1279C>T p.R427C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 23334668 blood-bone marrow recurrent 16.3 ENSP00000342376.3:p.Arg427Cys ENST00000342916.7:c.1279C>T 7:g.55157734C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2014_Lung_sq_82_T 2744953 2603656 lung NS NS NS carcinoma NS NS NS y COSV51818649 COSM7238502 106263170 c.1362G>T p.K454N Substitution - Missense 38 7:55160202-55160202 + - PATHOGENIC .92978 Confirmed somatic variant 583 NS primary 62 ENSP00000342376.3:p.Lys454Asn ENST00000342916.7:c.1362G>T 7:g.55160202G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0005127-T01-IM5 2721532 2580353 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51802355 COSM6941144 106240473 c.1154C>T p.P385L Substitution - Missense het 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000342376.3:p.Pro385Leu ENST00000342916.7:c.1154C>T 7:g.55156779C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 7C 2549418 2410873 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51792433 COSM6966446 106253906 c.1762G>A p.G588S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 646 NS primary 66 ENSP00000342376.3:p.Gly588Ser ENST00000342916.7:c.1762G>A 7:g.55165319G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 B103-S1 2732514 2591270 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV104576423 COSM9498532 106243163 c.1701G>T p.M567I Substitution - Missense 38 7:55163802-55163802 + - PATHOGENIC .93931 Confirmed somatic variant 29244145 surgery fresh/frozen primary 74.3 ENSP00000342376.3:p.Met567Ile ENST00000342916.7:c.1701G>T 7:g.55163802G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-D7-6521-01 2198059 2066337 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51778897 COSM3881800 106262609 c.253G>A p.V85M Substitution - Missense 38 7:55143317-55143317 + - PATHOGENIC .99051 Confirmed somatic variant 541 NS NS 65 ENSP00000342376.3:p.Val85Met ENST00000342916.7:c.253G>A 7:g.55143317G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S06-38853-TP 2366573 2229456 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51796296 COSM4992967 106260641 c.1640G>A p.R547K Substitution - Missense het 38 7:55163741-55163741 + - PATHOGENIC .992 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000342376.3:p.Arg547Lys ENST00000342916.7:c.1640G>A 7:g.55163741G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 ILMN13 2816773 2673124 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51797307 COSM1090871 106249307 c.1310C>A p.S437Y Substitution - Missense 38 7:55160150-55160150 + - PATHOGENIC .98943 Confirmed somatic variant 29937994 surgery fresh/frozen NS 54 ENSP00000342376.3:p.Ser437Tyr ENST00000342916.7:c.1310C>A 7:g.55160150C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-OL-A5RZ-01 2187696 2055974 breast NS NS NS carcinoma NS NS NS y COSV99288978 COSM7695792 106248783 c.289G>C p.E97Q Substitution - Missense 38 7:55143353-55143353 + - PATHOGENIC .94007 Confirmed somatic variant 414 NS NS 57 ENSP00000342376.3:p.Glu97Gln ENST00000342916.7:c.289G>C 7:g.55143353G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PTC-7C 2185970 2054267 thyroid NS NS NS other neoplasm NS NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 589 NS NS ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PCA0136 2580109 2441446 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51788967 COSM6005513 106257744 c.446G>A p.R149Q Substitution - Missense 38 7:55146627-55146627 + - PATHOGENIC .75281 Confirmed somatic variant 20579941 surgery fresh/frozen primary 54 ENSP00000342376.3:p.Arg149Gln ENST00000342916.7:c.446G>A 7:g.55146627G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003108-T01-IM5 2829558 2685373 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51866279 COSM6926300 106241241 c.665G>A p.R222H Substitution - Missense 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 30205045 surgery-fixed metastasis 37 ENSP00000342376.3:p.Arg222His ENST00000342916.7:c.665G>A 7:g.55152582G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-14-1455 2108036 1985897 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 106245463 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Thr363Ile ENST00000342916.7:c.1088C>T 7:g.55156614C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-12-3650-01 2120284 1994520 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 46 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 s_DS_scb_02_tumour 2861572 2716810 urinary_tract bladder NS NS carcinoma small_cell_carcinoma NS NS n COSV105109947 COSM9575249 106249150 c.673G>A p.G225S Substitution - Missense 38 7:55152590-55152590 + - PATHOGENIC .99676 Confirmed somatic variant 29180607 surgery-fixed NS 68 ENSP00000342376.3:p.Gly225Ser ENST00000342916.7:c.673G>A 7:g.55152590G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0007813-T01-IM5 2724038 2582859 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767730 COSM6548312 106242515 c.662G>T p.G221V Substitution - Missense het 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000342376.3:p.Gly221Val ENST00000342916.7:c.662G>T 7:g.55152579G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1461 2602435 2463311 large_intestine right NS NS carcinoma adenocarcinoma NS NS n COSV51813913 COSM6023901 106243021 c.344A>C p.N115T Substitution - Missense 38 7:55143408-55143408 + - PATHOGENIC .92454 Confirmed somatic variant 27121310 surgery fresh/frozen NS 47 ENSP00000342376.3:p.Asn115Thr ENST00000342916.7:c.344A>C 7:g.55143408A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-HT-8110-01 2194393 2062671 central_nervous_system brain NS NS glioma NS NS NS y COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 545 NS NS 57 ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 LC_C30 1863711 1754602 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 22975805 surgery fresh/frozen primary 38 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-S9-A7IX-01 2263383 2130367 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 57 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-14-0786-01 1337986 1248371 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-B5-A11E-01 1783399 1687398 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99287802 COSM9037443 106260976 c.529T>C p.S177P Substitution - Missense 38 7:55146710-55146710 + - NEUTRAL .17589 Confirmed somatic variant 419 fresh/frozen - NOS primary 53 ENSP00000342376.3:p.Ser177Pro ENST00000342916.7:c.529T>C 7:g.55146710T>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-AM-5821-01 1651151 1565938 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV99291226 COSM7552389 106251847 c.1124C>T p.A375V Substitution - Missense 38 7:55156650-55156650 + - PATHOGENIC .98971 Confirmed somatic variant 376 NS NS 68 ENSP00000342376.3:p.Ala375Val ENST00000342916.7:c.1124C>T 7:g.55156650C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-BH-A18U-01 1899961 1788645 breast NS NS NS carcinoma NS NS NS y COSV99294745 COSM7670588 106255264 c.769G>A p.E257K Substitution - Missense 38 7:55154032-55154032 + - PATHOGENIC .97243 Confirmed somatic variant 414 fresh/frozen - NOS primary 72 ENSP00000342376.3:p.Glu257Lys ENST00000342916.7:c.769G>A 7:g.55154032G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-12-3650-01 2120284 1994520 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51845825 COSM3412188 106244230 c.1280G>T p.R427L Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .99702 Confirmed somatic variant 329 NS NS 46 ENSP00000342376.3:p.Arg427Leu ENST00000342916.7:c.1280G>T 7:g.55157735G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T3010 2658443 2518602 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 106243472 c.1580G>A p.R527Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 74.08 ENSP00000342376.3:p.Arg527Gln ENST00000342916.7:c.1580G>A 7:g.55161580G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0008450-T01-IM5 2724567 2583388 skin NS NS NS malignant_melanoma NS NS NS n COSV51822498 COSM3266565 106254394 c.917C>T p.S306L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ser306Leu ENST00000342916.7:c.917C>T 7:g.55155857C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-EE-A2MR-06 2121688 1995924 skin NS NS NS malignant_melanoma NS NS NS y COSV51788720 COSM3639737 106261070 c.1534C>T p.P512S Substitution - Missense 38 7:55161534-55161534 + - NEUTRAL .03494 Confirmed somatic variant 540 NS NS 61 ENSP00000342376.3:p.Pro512Ser ENST00000342916.7:c.1534C>T 7:g.55161534C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009852-T01-IM5 2725690 2584511 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51768139 COSM21685 106240722 c.866C>A p.A289D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Asp ENST00000342916.7:c.866C>A 7:g.55154129C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0004510-T01-IM5 2720910 2579731 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-OX-A56R-01 2178260 2046558 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 68 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-28-1757-01 2178083 2046381 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 71 ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 YUKLAB 2013569 1896201 skin NS NS NS malignant_melanoma NS NS NS y COSV51796177 COSM1698689 106256648 c.1189A>T p.T397S Substitution - Missense het 38 7:55156814-55156814 + - PATHOGENIC .9893 Confirmed somatic variant 22842228 surgery fresh/frozen metastasis 84 ENSP00000342376.3:p.Thr397Ser ENST00000342916.7:c.1189A>T 7:g.55156814A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-EE-A2MI-06 2121680 1995916 skin NS NS NS malignant_melanoma NS NS NS y COSV51783517 COSM3639743 106239069 c.1864C>T p.P622S Substitution - Missense 38 7:55165421-55165421 + - NEUTRAL .20892 Confirmed somatic variant 540 NS NS 43 ENSP00000342376.3:p.Pro622Ser ENST00000342916.7:c.1864C>T 7:g.55165421C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003739-T01-IM5 2720227 2579048 soft_tissue blood_vessel skin NS angiosarcoma NS NS NS n COSV51783517 COSM3639743 106239069 c.1864C>T p.P622S Substitution - Missense het 38 7:55165421-55165421 + - NEUTRAL .20892 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Pro622Ser ENST00000342916.7:c.1864C>T 7:g.55165421C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0004688-T01-IM5 2721089 2579910 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51823965 COSM6937748 106251424 c.76G>A p.E26K Substitution - Missense het 38 7:55019353-55019353 + - PATHOGENIC .70393 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Glu26Lys ENST00000342916.7:c.76G>A 7:g.55019353G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S10-24679-TP 2366580 2229463 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51808100 COSM4992964 106266162 c.818C>T p.T273I Substitution - Missense het 38 7:55154081-55154081 + - PATHOGENIC .9224 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000342376.3:p.Thr273Ile ENST00000342916.7:c.818C>T 7:g.55154081C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0002999-T01-IM3 2719208 2578029 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 106243142 c.755G>A p.R252H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg252His ENST00000342916.7:c.755G>A 7:g.55154018G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-2563-01 1337882 1248267 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 106242169 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000342376.3:p.Arg252Cys ENST00000342916.7:c.754C>T 7:g.55154017C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0011544-T01-IM5 2727116 2585937 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51774354 COSM6981709 106267708 c.951G>C p.E317D Substitution - Missense het 38 7:55155891-55155891 + - PATHOGENIC .93673 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Glu317Asp ENST00000342916.7:c.951G>C 7:g.55155891G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577025 COSM9413133 106271039 c.1326C>G p.S442R Substitution - Missense 38 7:55160166-55160166 + - NEUTRAL .15107 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000342376.3:p.Ser442Arg ENST00000342916.7:c.1326C>G 7:g.55160166C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-2565-01 1337884 1248269 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0001328-T01-IM3 2717084 2575905 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51833335 COSM6916442 106246575 c.14G>C p.G5A Substitution - Missense het 38 7:55019291-55019291 + - NEUTRAL .0753 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Gly5Ala ENST00000342916.7:c.14G>C 7:g.55019291G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1022 2491916 2354545 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS y COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 26437033 surgery fresh/frozen NS 55 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV104369000 COSM9233361 106254234 c.352G>T p.A118S Substitution - Missense het 38 7:55143416-55143416 + - PATHOGENIC .99878 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000342376.3:p.Ala118Ser ENST00000342916.7:c.352G>T 7:g.55143416G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577026 COSM9413136 106271050 c.1393G>C p.G465R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .4176 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000342376.3:p.Gly465Arg ENST00000342916.7:c.1393G>C 7:g.55160233G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006622-T01-IM5 2829996 2685811 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51845994 COSM5530405 106239506 c.1633G>A p.E545K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 30205045 surgery-fixed primary 43 ENSP00000342376.3:p.Glu545Lys ENST00000342916.7:c.1633G>A 7:g.55163734G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2503528 2503528 2365878 autonomic_ganglia sinonasal_and_nasal_cavity NS NS olfactory_neuroblastoma NS NS NS n COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense het 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 27149458 surgery - NOS NS 44 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-AM-5820-01 1651150 1565937 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 376 NS NS 59 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MTP18_T2 2875798 2730360 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 32796935 surgery-fixed NS 74 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577027 COSM9413135 106247580 c.1394G>A p.G465E Substitution - Missense 38 7:55160234-55160234 + - NEUTRAL .11765 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000342376.3:p.Gly465Glu ENST00000342916.7:c.1394G>A 7:g.55160234G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 EXTERN_MELA_20140514_002 2839308 2695074 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51866168 COSM3266611 106249127 c.1840G>A p.G614S Substitution - Missense 38 7:55165397-55165397 + - NEUTRAL .00559 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000342376.3:p.Gly614Ser ENST00000342916.7:c.1840G>A 7:g.55165397G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 007 2640411 2500713 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS y COSV51815598 COSM6471954 106247618 c.1325G>T p.S442I Substitution - Missense 38 7:55160165-55160165 + - NEUTRAL .44157 Confirmed somatic variant 27545006 fixed - NOS NS 57 ENSP00000342376.3:p.Ser442Ile ENST00000342916.7:c.1325G>T 7:g.55160165G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006437-T01-IM5 2722813 2581634 skin NS NS NS adnexal_tumour malignant_adnexal_tumour NS NS n COSV51788796 COSM4680390 106250329 c.293G>A p.R98Q Substitution - Missense het 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg98Gln ENST00000342916.7:c.293G>A 7:g.55143357G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2014_Lung_sq_06_T 2744877 2603580 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 77 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 RS33T 2653643 2513765 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS primary 67.09 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 SJALL040461-R 2824036 2679864 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV104576718 COSM9280424 106245500 c.1592G>A p.R531Q Substitution - Missense 38 7:55161592-55161592 + - PATHOGENIC .99386 Confirmed somatic variant 31697823 blood-bone marrow recurrent 11.64 ENSP00000342376.3:p.Arg531Gln ENST00000342916.7:c.1592G>A 7:g.55161592G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 96737 1973055 1859299 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSV51777851 COSM1205052 106248087 c.494G>A p.R165Q Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .0375 Confirmed somatic variant 23680147 surgery - NOS primary ENSP00000342376.3:p.Arg165Gln ENST00000342916.7:c.494G>A 7:g.55146675G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0010967-T01-IM5 2726608 2585429 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51856949 COSM6978220 106268122 c.413G>T p.R138I Substitution - Missense het 38 7:55143477-55143477 + - PATHOGENIC .94211 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg138Ile ENST00000342916.7:c.413G>T 7:g.55143477G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PCSI_0590_Pa_P_526 2507081 2369417 pancreas NS NS NS carcinoma NS NS NS y COSV51771539 COSM5760860 106269356 c.1705A>G p.I569V Substitution - Missense 38 7:55163806-55163806 + - NEUTRAL .01956 Confirmed somatic variant 382 NS primary 73 ENSP00000342376.3:p.Ile569Val ENST00000342916.7:c.1705A>G 7:g.55163806A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0008346-T01-IM5 2830127 2685942 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51838649 COSM6962468 106255948 c.412A>G p.R138G Substitution - Missense 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 30205045 surgery-fixed primary 61 ENSP00000342376.3:p.Arg138Gly ENST00000342916.7:c.412A>G 7:g.55143476A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 587342 1766789 1671109 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51777851 COSM1205052 106248087 c.494G>A p.R165Q Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .0375 Confirmed somatic variant 22895193 surgery fresh/frozen primary ENSP00000342376.3:p.Arg165Gln ENST00000342916.7:c.494G>A 7:g.55146675G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0007018-T01-IM5 2723393 2582214 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765787 COSM2149971 106241217 c.910C>T p.H304Y Substitution - Missense het 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.His304Tyr ENST00000342916.7:c.910C>T 7:g.55155850C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0000154-T01-IM3 2714713 2573534 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51819471 COSM6909030 106249568 c.1273A>C p.I425L Substitution - Missense het 38 7:55157728-55157728 + - PATHOGENIC .99224 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ile425Leu ENST00000342916.7:c.1273A>C 7:g.55157728A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-RD-A7BT-01 2263044 2130028 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99295752 COSM8178996 106250850 c.715G>A p.G239S Substitution - Missense 38 7:55152632-55152632 + - PATHOGENIC .99504 Confirmed somatic variant 541 NS primary 66 ENSP00000342376.3:p.Gly239Ser ENST00000342916.7:c.715G>A 7:g.55152632G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 106246290 c.1391C>T p.S464L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000342376.3:p.Ser464Leu ENST00000342916.7:c.1391C>T 7:g.55160231C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 Br306T 1313064 1223973 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 surgery - NOS primary 51 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577028 COSM9413137 106271074 c.1472T>A p.I491K Substitution - Missense 38 7:55160312-55160312 + - NEUTRAL .08768 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000342376.3:p.Ile491Lys ENST00000342916.7:c.1472T>A 7:g.55160312T>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0010130-T01-IM5 2725937 2584758 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51788796 COSM4680390 106250329 c.293G>A p.R98Q Substitution - Missense het 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Arg98Gln ENST00000342916.7:c.293G>A 7:g.55143357G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 YUSCO 2013686 1896318 skin NS NS NS malignant_melanoma NS NS NS y COSV51778830 COSM1698691 106241516 c.1198G>A p.E400K Substitution - Missense het 38 7:55156823-55156823 + - PATHOGENIC .99571 Confirmed somatic variant 22842228 NS NS ENSP00000342376.3:p.Glu400Lys ENST00000342916.7:c.1198G>A 7:g.55156823G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-EE-A2M7-06 2121673 1995909 skin NS NS NS malignant_melanoma NS NS NS y COSV51790699 COSM3639729 106250428 c.791G>A p.C264Y Substitution - Missense 38 7:55154054-55154054 + - PATHOGENIC .99369 Confirmed somatic variant 540 NS NS 66 ENSP00000342376.3:p.Cys264Tyr ENST00000342916.7:c.791G>A 7:g.55154054G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PCA1587 2861424 2716668 prostate NS NS NS carcinoma NS NS NS n COSV105111146 COSM9581090 106266652 c.1879G>C p.G627R Substitution - Missense 38 7:55165436-55165436 + - PATHOGENIC .99177 Confirmed somatic variant 32268276 circulating tumour NS ENSP00000342376.3:p.Gly627Arg ENST00000342916.7:c.1879G>C 7:g.55165436G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576891 COSM9396331 106246095 c.1400A>C p.K467T Substitution - Missense 38 7:55160240-55160240 + - NEUTRAL .10442 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000342376.3:p.Lys467Thr ENST00000342916.7:c.1400A>C 7:g.55160240A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GBM7-I2 2813444 2669836 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 123 2748095 2606798 stomach NS NS NS carcinoma NS NS NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 683 NS primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0005127-T01-IM5 2721532 2580353 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51794869 COSM4362780 106240452 c.574C>T p.P192S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000342376.3:p.Pro192Ser ENST00000342916.7:c.574C>T 7:g.55151308C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0004837-T01-IM5 2721240 2580061 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51812540 COSM1451536 106248678 c.322A>G p.R108G Substitution - Missense het 38 7:55143386-55143386 + - PATHOGENIC .72671 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Arg108Gly ENST00000342916.7:c.322A>G 7:g.55143386A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 XHDG25C 2321255 2186409 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV51811244 COSM4767521 106241457 c.607G>A p.G203R Substitution - Missense 38 7:55151341-55151341 + - PATHOGENIC .99471 Confirmed somatic variant 24997986 NS NS 77 ENSP00000342376.3:p.Gly203Arg ENST00000342916.7:c.607G>A 7:g.55151341G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-BA-6872-01 2193616 2061894 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99294544 COSM8387616 106248749 c.571G>A p.D191N Substitution - Missense 38 7:55151305-55151305 + - PATHOGENIC .93234 Confirmed somatic variant 627 NS NS 47 ENSP00000342376.3:p.Asp191Asn ENST00000342916.7:c.571G>A 7:g.55151305G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003350-T01-IM5 2719841 2578662 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51815967 COSM39522 106240671 c.655T>G p.C219G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Cys219Gly ENST00000342916.7:c.655T>G 7:g.55152572T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0008262-T01-IM5 2724401 2583222 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T1748 2658268 2518427 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51796395 COSM6652238 106263122 c.1244C>T p.T415M Substitution - Missense 38 7:55157699-55157699 + - PATHOGENIC .97374 Confirmed somatic variant 27149842 NS NS 85.08 ENSP00000342376.3:p.Thr415Met ENST00000342916.7:c.1244C>T 7:g.55157699C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-12-0707-01 2178095 2046393 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 106241525 c.809A>G p.Y270C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 329 NS NS 55 ENSP00000342376.3:p.Tyr270Cys ENST00000342916.7:c.809A>G 7:g.55154072A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 19T 2745856 2604559 liver NS NS NS other neoplasm NS NS y COSV51840438 COSM1727959 106248260 c.374A>G p.Y125C Substitution - Missense 38 7:55143438-55143438 + - PATHOGENIC .99088 Confirmed somatic variant 660 NS primary 71 ENSP00000342376.3:p.Tyr125Cys ENST00000342916.7:c.374A>G 7:g.55143438A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577024 COSM9413134 106271033 c.1322T>A p.V441D Substitution - Missense 38 7:55160162-55160162 + - PATHOGENIC .92743 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000342376.3:p.Val441Asp ENST00000342916.7:c.1322T>A 7:g.55160162T>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0000785-T01-IM3 2715984 2574805 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767730 COSM6548312 106242515 c.662G>T p.G221V Substitution - Missense het 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Gly221Val ENST00000342916.7:c.662G>T 7:g.55152579G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 pfg043T 2309624 2174826 stomach NS NS NS carcinoma intestinal_adenocarcinoma NS NS y COSV51790826 COSM4755611 106241553 c.566A>C p.K189T Substitution - Missense het 38 7:55151300-55151300 + - PATHOGENIC .93585 Confirmed somatic variant 24816253 surgery fresh/frozen NS 76 ENSP00000342376.3:p.Lys189Thr ENST00000342916.7:c.566A>C 7:g.55151300A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GBM7-I2 2813444 2669836 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99293015 COSM9210724 106249101 c.1871G>C p.C624S Substitution - Missense 38 7:55165428-55165428 + - PATHOGENIC .99908 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000342376.3:p.Cys624Ser ENST00000342916.7:c.1871G>C 7:g.55165428G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 LICA-CN-HCC131T 2634178 2494574 liver NS NS NS other neoplasm NS NS y COSV51799496 COSM5824594 106251458 c.244A>T p.I82F Substitution - Missense 38 7:55143308-55143308 + - PATHOGENIC .99415 Confirmed somatic variant 660 NS primary 49 ENSP00000342376.3:p.Ile82Phe ENST00000342916.7:c.244A>T 7:g.55143308A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DD-A73A-01 2194652 2062930 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51846765 COSM4916543 106242392 c.1232C>G p.P411R Substitution - Missense 38 7:55157687-55157687 + - PATHOGENIC .99735 Confirmed somatic variant 628 NS NS 71 ENSP00000342376.3:p.Pro411Arg ENST00000342916.7:c.1232C>G 7:g.55157687C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-AX-A06F-01 2198328 2066606 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99294241 COSM8943299 106255513 c.710C>A p.A237D Substitution - Missense 38 7:55152627-55152627 + - PATHOGENIC .99353 Confirmed somatic variant 419 NS NS 59 ENSP00000342376.3:p.Ala237Asp ENST00000342916.7:c.710C>A 7:g.55152627C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-32-1991-01 2120347 1994583 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 60 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 R074-R1 2813496 2669888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 41 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0005051-T01-IM5 2721455 2580276 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-EE-A29D-06 2121635 1995871 skin NS NS NS malignant_melanoma NS NS NS y COSV51799159 COSM747427 106250791 c.1766C>T p.P589L Substitution - Missense 38 7:55165323-55165323 + - PATHOGENIC .95834 Confirmed somatic variant 540 NS NS 87 ENSP00000342376.3:p.Pro589Leu ENST00000342916.7:c.1766C>T 7:g.55165323C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009711-T01-IM5 2725587 2584408 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-28-5209-01 2120334 1994570 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51808387 COSM3412196 106247656 c.1793G>C p.G598A Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 329 NS NS 66 ENSP00000342376.3:p.Gly598Ala ENST00000342916.7:c.1793G>C 7:g.55165350G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 IGC-10-1053 2662337 2522461 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51767730 COSM6548312 106242515 c.662G>T p.G221V Substitution - Missense 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000342376.3:p.Gly221Val ENST00000342916.7:c.662G>T 7:g.55152579G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0649-01 1337849 1248234 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51791901 COSM2151461 106255456 c.991G>A p.G331R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .96902 Confirmed somatic variant 329 surgery fresh/frozen NS 73 ENSP00000342376.3:p.Gly331Arg ENST00000342916.7:c.991G>A 7:g.55155931G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S001073 1027682 944658 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2625883 2625883 2486295 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51796381 COSM6191457 106263106 c.1867A>T p.N623Y Substitution - Missense 38 7:55165424-55165424 + - PATHOGENIC .99705 Confirmed somatic variant 25617745 surgery-fixed NS 61 ENSP00000342376.3:p.Asn623Tyr ENST00000342916.7:c.1867A>T 7:g.55165424A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0008927-T01-IM5 2724943 2583764 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51767495 COSM35752 106242169 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg252Cys ENST00000342916.7:c.754C>T 7:g.55154017C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2876654 2876654 2731169 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 circulating tumour NS 63 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PD7044a 1504255 1427133 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51826432 COSM4384121 106255478 c.1570G>A p.V524I Substitution - Missense 38 7:55161570-55161570 + - PATHOGENIC .78109 Confirmed somatic variant 24030381 NS NS ENSP00000342376.3:p.Val524Ile ENST00000342916.7:c.1570G>A 7:g.55161570G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-EE-A17X-06 2121618 1995854 skin NS NS NS malignant_melanoma NS NS NS y COSV51781835 COSM174732 106241611 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 540 NS NS 54 ENSP00000342376.3:p.Glu114Lys ENST00000342916.7:c.340G>A 7:g.55143404G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-26-1439-01 2120320 1994556 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 63 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0125-02 2120245 1994481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 64 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-CV-7252-01 2193523 2061801 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 627 NS NS 62 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2772383 2772383 2630573 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV99290341 COSM7347800 106260424 c.1016G>A p.G339E Substitution - Missense 38 7:55156542-55156542 + - PATHOGENIC .99668 Confirmed somatic variant 29807833 circulating tumour NS ENSP00000342376.3:p.Gly339Glu ENST00000342916.7:c.1016G>A 7:g.55156542G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006054-T01-IM5 2722434 2581255 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0004225-T01-IM5 2720632 2579453 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV51771772 COSM6934070 106270845 c.1299T>A p.H433Q Substitution - Missense het 38 7:55160139-55160139 + - PATHOGENIC .93122 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.His433Gln ENST00000342916.7:c.1299T>A 7:g.55160139T>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-AR-A2LR-01 2187807 2056085 breast NS NS NS carcinoma NS NS NS y COSV51781835 COSM174732 106241611 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 414 NS NS 49 ENSP00000342376.3:p.Glu114Lys ENST00000342916.7:c.340G>A 7:g.55143404G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PD6780a 1503990 1426868 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia_with_ringed_sideroblasts NS n COSV51791654 COSM4384111 106255566 c.95A>G p.Q32R Substitution - Missense 38 7:55142292-55142292 + - PATHOGENIC .96882 Confirmed somatic variant 24030381 NS NS ENSP00000342376.3:p.Gln32Arg ENST00000342916.7:c.95A>G 7:g.55142292A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003393-T01-IM5 2829603 2685418 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51792310 COSM6928197 106242536 c.50C>T p.A17V Substitution - Missense 38 7:55019327-55019327 + - NEUTRAL .01177 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000342376.3:p.Ala17Val ENST00000342916.7:c.50C>T 7:g.55019327C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DU-7292-01 2194421 2062699 central_nervous_system brain NS NS glioma NS NS NS y COSV51800797 COSM3412178 106244249 c.755G>C p.R252P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 545 NS NS 69 ENSP00000342376.3:p.Arg252Pro ENST00000342916.7:c.755G>C 7:g.55154018G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-2561-01 1337880 1248265 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51841003 COSM3412168 106262745 c.445C>T p.R149W Substitution - Missense 38 7:55146626-55146626 + - PATHOGENIC .93775 Confirmed somatic variant 329 surgery fresh/frozen NS 53 ENSP00000342376.3:p.Arg149Trp ENST00000342916.7:c.445C>T 7:g.55146626C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0004837-T01-IM5 2721240 2580061 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0001042-T01-IM3 2716511 2575332 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0000657-T02-IM5 2719370 2578191 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 106247656 c.1793G>C p.G598A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Gly598Ala ENST00000342916.7:c.1793G>C 7:g.55165350G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2625883 2625883 2486295 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51796371 COSM6191453 106263099 c.203C>T p.T68I Substitution - Missense 38 7:55142400-55142400 + - PATHOGENIC .99116 Confirmed somatic variant 25617745 surgery-fixed NS 61 ENSP00000342376.3:p.Thr68Ile ENST00000342916.7:c.203C>T 7:g.55142400C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-D1-A2G5-01 2198276 2066554 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99295137 COSM8817249 106255827 c.1873A>G p.T625A Substitution - Missense 38 7:55165430-55165430 + - PATHOGENIC .99619 Confirmed somatic variant 419 NS NS 50 ENSP00000342376.3:p.Thr625Ala ENST00000342916.7:c.1873A>G 7:g.55165430A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0001248-T01-IM3 2716920 2575741 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51855488 COSM4166393 106246435 c.710C>T p.A237V Substitution - Missense het 38 7:55152627-55152627 + - PATHOGENIC .99229 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Ala237Val ENST00000342916.7:c.710C>T 7:g.55152627C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0005370-T01-IM5 2721774 2580595 skin NS NS NS malignant_melanoma NS NS NS n COSV51794869 COSM4362780 106240452 c.574C>T p.P192S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Pro192Ser ENST00000342916.7:c.574C>T 7:g.55151308C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-FR-A8YC-06 2263445 2130429 skin NS NS NS malignant_melanoma NS NS NS y COSV51772860 COSM5872872 106255226 c.683C>T p.P228L Substitution - Missense 38 7:55152600-55152600 + - PATHOGENIC .99115 Confirmed somatic variant 540 NS NS 78 ENSP00000342376.3:p.Pro228Leu ENST00000342916.7:c.683C>T 7:g.55152600C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-OL-A97C-01 2386126 2248958 breast NS NS NS carcinoma NS NS NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 414 NS primary 67 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 SF268 1998472 1883544 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 23856246 cell-line primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1894611 1894611 1783303 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51837871 COSM1238072 106270385 c.1636C>T p.P546S Substitution - Missense hom 38 7:55163737-55163737 + - PATHOGENIC .99252 Confirmed somatic variant 23578570 surgery-fixed NS 33 ENSP00000342376.3:p.Pro546Ser ENST00000342916.7:c.1636C>T 7:g.55163737C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 106240722 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000342376.3:p.Ala289Asp ENST00000342916.7:c.866C>A 7:g.55154129C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GBM_IV-35 2354292 2218450 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 98019 1520664 1443039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51786915 COSM94179 106245081 c.610G>A p.E204K Substitution - Missense 38 7:55151344-55151344 + - NEUTRAL .0681 Confirmed somatic variant 20668451 NS primary ENSP00000342376.3:p.Glu204Lys ENST00000342916.7:c.610G>A 7:g.55151344G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-2563 2108004 1985865 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 106242169 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Arg252Cys ENST00000342916.7:c.754C>T 7:g.55154017C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0007994-T01-IM5 2724178 2582999 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51811471 COSM6960839 106255930 c.380C>A p.A127E Substitution - Missense het 38 7:55143444-55143444 + - NEUTRAL .44126 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Ala127Glu ENST00000342916.7:c.380C>A 7:g.55143444C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MELA_20076 2760731 2619264 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 106241928 c.1168C>A p.Q390K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 30178487 surgery fresh/frozen metastasis 30 ENSP00000342376.3:p.Gln390Lys ENST00000342916.7:c.1168C>A 7:g.55156793C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-EE-A3AB-06 2121693 1995929 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 106241928 c.1168C>A p.Q390K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 540 NS NS 30 ENSP00000342376.3:p.Gln390Lys ENST00000342916.7:c.1168C>A 7:g.55156793C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003393-T01-IM5 2719877 2578698 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51792310 COSM6928197 106242536 c.50C>T p.A17V Substitution - Missense het 38 7:55019327-55019327 + - NEUTRAL .01177 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Ala17Val ENST00000342916.7:c.50C>T 7:g.55019327C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 18195 2422953 2285875 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV51779680 COSM1313184 106252323 c.1151C>G p.T384S Substitution - Missense 38 7:55156776-55156776 + - PATHOGENIC .98418 Confirmed somatic variant 24469795 NS NS 61 ENSP00000342376.3:p.Thr384Ser ENST00000342916.7:c.1151C>G 7:g.55156776C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006119-T01-IM5 2722498 2581319 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51836444 COSM6948255 106265405 c.496G>A p.D166N Substitution - Missense het 38 7:55146677-55146677 + - PATHOGENIC .99816 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Asp166Asn ENST00000342916.7:c.496G>A 7:g.55146677G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-A6S1-01 2263260 2130244 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS primary 53 ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51776247 COSM6110417 106247348 c.1393G>A p.G465R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000342376.3:p.Gly465Arg ENST00000342916.7:c.1393G>A 7:g.55160233G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194735 1194735 1106630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-16-0849-01 2178109 2046407 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 54 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0005378-T01-IM5 2721782 2580603 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51862161 COSM6943352 106239234 c.73C>G p.L25V Substitution - Missense het 38 7:55019350-55019350 + - NEUTRAL .21138 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Leu25Val ENST00000342916.7:c.73C>G 7:g.55019350C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GBM7-I1 2813443 2669835 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 HCC-JP-457-T 2746985 2605688 liver NS NS NS other neoplasm NS NS y COSV51770509 COSM7191105 106254508 c.1870T>G p.C624G Substitution - Missense 38 7:55165427-55165427 + - PATHOGENIC .99836 Confirmed somatic variant 323 NS primary 77 ENSP00000342376.3:p.Cys624Gly ENST00000342916.7:c.1870T>G 7:g.55165427T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0008927-T01-IM5 2724943 2583764 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51768139 COSM21685 106240722 c.866C>A p.A289D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Asp ENST00000342916.7:c.866C>A 7:g.55154129C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 16678 1423698 1333726 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51812036 COSM48318 106264421 c.1789G>A p.A597T Substitution - Missense het 38 7:55165346-55165346 + - NEUTRAL .27484 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000342376.3:p.Ala597Thr ENST00000342916.7:c.1789G>A 7:g.55165346G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0013704-T01-IM5 2803863 2660613 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51781835 COSM174732 106241611 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 29316426 surgery-fixed primary 71 ENSP00000342376.3:p.Glu114Lys ENST00000342916.7:c.340G>A 7:g.55143404G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 R074-R1 2813496 2669888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99297135 COSM9212199 106248557 c.865G>T p.A289S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 41 ENSP00000342376.3:p.Ala289Ser ENST00000342916.7:c.865G>T 7:g.55154128G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006119-T01-IM5 2722498 2581319 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51836484 COSM6948259 106265432 c.857G>A p.S286N Substitution - Missense het 38 7:55154120-55154120 + - PATHOGENIC .95351 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Ser286Asn ENST00000342916.7:c.857G>A 7:g.55154120G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 171T 2473937 2336707 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 26489445 fixed - NOS NS ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-BR-4256-01 2198141 2066419 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51797215 COSM145360 106244577 c.967G>A p.V323I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 541 NS NS 80 ENSP00000342376.3:p.Val323Ile ENST00000342916.7:c.967G>A 7:g.55155907G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2757166 2757166 2615808 haematopoietic_and_lymphoid_tissue skin NS NS lymphoid_neoplasm mycosis_fungoides-Sezary_syndrome NS NS y COSV104576496 COSM9308820 106259889 c.1246G>A p.D416N Substitution - Missense 38 7:55157701-55157701 + - PATHOGENIC .96223 Confirmed somatic variant 26551670 blood-bone marrow secondary ENSP00000342376.3:p.Asp416Asn ENST00000342916.7:c.1246G>A 7:g.55157701G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GBM12 2144553 2013767 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 24285547 surgery fresh/frozen primary 64 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-AA-3982-01 1651089 1565876 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51769747 COSM297803 106253755 c.907G>C p.D303H Substitution - Missense 38 7:55155847-55155847 + - PATHOGENIC .99461 Confirmed somatic variant 22810696 376 NS NS 75 ENSP00000342376.3:p.Asp303His ENST00000342916.7:c.907G>C 7:g.55155847G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003417-T01-IM5 2719901 2578722 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS n COSV51815967 COSM39522 106240671 c.655T>G p.C219G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Cys219Gly ENST00000342916.7:c.655T>G 7:g.55152572T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CHC1774T 2340683 2205666 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51807517 COSM4802395 106259080 c.67C>T p.R23W Substitution - Missense 38 7:55019344-55019344 + - NEUTRAL .00803 Confirmed somatic variant 381 NS primary 65 ENSP00000342376.3:p.Arg23Trp ENST00000342916.7:c.67C>T 7:g.55019344C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-IR-A3LA-01 2193391 2061669 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51796224 COSM4844514 106256665 c.1648G>C p.V550L Substitution - Missense 38 7:55163749-55163749 + - PATHOGENIC .98124 Confirmed somatic variant 415 NS NS 60 ENSP00000342376.3:p.Val550Leu ENST00000342916.7:c.1648G>C 7:g.55163749G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 5-VS034-T2 2869859 2724856 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51802355 COSM6941144 106240473 c.1154C>T p.P385L Substitution - Missense 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 26950094 surgery - NOS NS 75 ENSP00000342376.3:p.Pro385Leu ENST00000342916.7:c.1154C>T 7:g.55156779C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S001018 1027698 944674 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51816377 COSM3412194 106239772 c.1786C>T p.P596S Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99531 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000342376.3:p.Pro596Ser ENST00000342916.7:c.1786C>T 7:g.55165343C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 APGI-AMP-2890 2866039 2721116 pancreas ampulla_of_Vater NS NS carcinoma ductal_carcinoma NS NS y COSV105111099 COSM9620623 106257839 c.661G>A p.G221R Substitution - Missense 38 7:55152578-55152578 + - NEUTRAL .36671 Confirmed somatic variant 26804919 surgery fresh/frozen NS ENSP00000342376.3:p.Gly221Arg ENST00000342916.7:c.661G>A 7:g.55152578G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0001042-T01-IM3 2716511 2575332 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51787557 COSM6191456 106240443 c.1337C>T p.T446I Substitution - Missense het 38 7:55160177-55160177 + - NEUTRAL .13103 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Thr446Ile ENST00000342916.7:c.1337C>T 7:g.55160177C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-14-2554-01 1338017 1248402 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 52 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003705-T01-IM5 2720193 2579014 large_intestine appendix NS NS carcinoma adenocarcinoma NS NS n COSV51812036 COSM48318 106264421 c.1789G>A p.A597T Substitution - Missense het 38 7:55165346-55165346 + - NEUTRAL .27484 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Ala597Thr ENST00000342916.7:c.1789G>A 7:g.55165346G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009239-T01-IM5 2725198 2584019 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51792469 COSM6967655 106250149 c.1607T>A p.V536E Substitution - Missense het 38 7:55161607-55161607 + - PATHOGENIC .99007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Val536Glu ENST00000342916.7:c.1607T>A 7:g.55161607T>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-GN-A269-01 2121799 1996035 skin NS NS NS malignant_melanoma NS NS NS y COSV51823432 COSM3639727 106246159 c.701A>G p.N234S Substitution - Missense 38 7:55152618-55152618 + - PATHOGENIC .95999 Confirmed somatic variant 540 NS NS 70 ENSP00000342376.3:p.Asn234Ser ENST00000342916.7:c.701A>G 7:g.55152618A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0005889-T01-IM5 2722273 2581094 testis NS NS NS germ_cell_tumour seminoma NS NS n COSV51857848 COSM6946731 106241878 c.1454G>A p.G485D Substitution - Missense het 38 7:55160294-55160294 + - NEUTRAL .16911 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000342376.3:p.Gly485Asp ENST00000342916.7:c.1454G>A 7:g.55160294G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1194723 1194723 1106618 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51853292 COSM29339 106260118 c.271A>C p.I91L Substitution - Missense 38 7:55143335-55143335 + - PATHOGENIC .99037 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000342376.3:p.Ile91Leu ENST00000342916.7:c.271A>C 7:g.55143335A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-EA-A410-01 2262924 2129908 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51769145 COSM3266559 106255214 c.874G>A p.V292M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 415 NS primary 51 ENSP00000342376.3:p.Val292Met ENST00000342916.7:c.874G>A 7:g.55154137G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T1803 2658686 2518845 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51850996 COSM6652242 106246766 c.1192G>A p.V398I Substitution - Missense 38 7:55156817-55156817 + - PATHOGENIC .99161 Confirmed somatic variant 27149842 NS NS 63 ENSP00000342376.3:p.Val398Ile ENST00000342916.7:c.1192G>A 7:g.55156817G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 PD6883a 1504094 1426972 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia NS n COSV51850592 COSM4384117 106244207 c.754C>G p.R252G Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .93941 Confirmed somatic variant 24030381 NS NS ENSP00000342376.3:p.Arg252Gly ENST00000342916.7:c.754C>G 7:g.55154017C>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0001971-T01-IM3 2718279 2577100 central_nervous_system brain NS NS glioma astrocytoma NS NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T3265 2658621 2518780 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51815655 COSM6652276 106270936 c.913G>A p.G305S Substitution - Missense 38 7:55155853-55155853 + - PATHOGENIC .97718 Confirmed somatic variant 27149842 NS NS 74.91 ENSP00000342376.3:p.Gly305Ser ENST00000342916.7:c.913G>A 7:g.55155853G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0012402-T01-IM5 2727458 2586279 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51850996 COSM6652242 106246766 c.1192G>A p.V398I Substitution - Missense het 38 7:55156817-55156817 + - PATHOGENIC .99161 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Val398Ile ENST00000342916.7:c.1192G>A 7:g.55156817G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-12-0670-01 2178104 2046402 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 106241473 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 NS NS 60 ENSP00000342376.3:p.Thr263Pro ENST00000342916.7:c.787A>C 7:g.55154050A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T3174 2658322 2518481 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 106243472 c.1580G>A p.R527Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 74.41 ENSP00000342376.3:p.Arg527Gln ENST00000342916.7:c.1580G>A 7:g.55161580G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0011107-T01-IM5 2726736 2585557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CHG-12-12649T 2634294 2494690 liver NS NS NS other neoplasm NS NS y COSV51767687 COSM6191352 106239215 c.1747G>A p.A583T Substitution - Missense 38 7:55165304-55165304 + - PATHOGENIC .98656 Confirmed somatic variant 660 NS primary 50 ENSP00000342376.3:p.Ala583Thr ENST00000342916.7:c.1747G>A 7:g.55165304G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-12-0670 2108025 1985886 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 106241473 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Thr263Pro ENST00000342916.7:c.787A>C 7:g.55154050A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-CD-A4MG-01 2198123 2066401 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51852047 COSM3881818 106247829 c.1289C>T p.T430I Substitution - Missense 38 7:55157744-55157744 + - PATHOGENIC .99429 Confirmed somatic variant 541 NS NS 76 ENSP00000342376.3:p.Thr430Ile ENST00000342916.7:c.1289C>T 7:g.55157744C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0011219-T01-IM5 2726835 2585656 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827895 COSM3412174 106241589 c.685A>T p.S229C Substitution - Missense het 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ser229Cys ENST00000342916.7:c.685A>T 7:g.55152602A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006846-T01-IM5 2723226 2582047 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DU-A5TY-01 2194202 2062480 central_nervous_system brain NS NS glioma NS NS NS y COSV51765881 COSM3929118 106262902 c.949G>A p.E317K Substitution - Missense 38 7:55155889-55155889 + - PATHOGENIC .99356 Confirmed somatic variant 545 NS NS 46 ENSP00000342376.3:p.Glu317Lys ENST00000342916.7:c.949G>A 7:g.55155889G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GBM12 2144553 2013767 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 24285547 surgery fresh/frozen primary 64 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 ATL020 2488648 2351297 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm adult_T_cell_lymphoma-leukaemia NS NS y COSV51770269 COSM5710629 106254436 c.1015G>A p.G339R Substitution - Missense 38 7:55156541-55156541 + - PATHOGENIC .9949 Confirmed somatic variant 26437031 NS NS 63 ENSP00000342376.3:p.Gly339Arg ENST00000342916.7:c.1015G>A 7:g.55156541G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 95504 1973048 1859292 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSV51812284 COSM1651737 106258347 c.821C>T p.T274M Substitution - Missense 38 7:55154084-55154084 + - PATHOGENIC .92031 Confirmed somatic variant 23680147 surgery - NOS primary ENSP00000342376.3:p.Thr274Met ENST00000342916.7:c.821C>T 7:g.55154084C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-MV-A51V-01 2193279 2061557 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51815409 COSM7143473 106246350 c.1169A>G p.Q390R Substitution - Missense 38 7:55156794-55156794 + - NEUTRAL .3199 Confirmed somatic variant 413 NS NS 75 ENSP00000342376.3:p.Gln390Arg ENST00000342916.7:c.1169A>G 7:g.55156794A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2812807 2812807 2669221 liver NS NS NS other adenoma NS NS n COSV51845994 COSM5530405 106239506 c.1633G>A p.E545K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 31189995 surgery-fixed NS 9 ENSP00000342376.3:p.Glu545Lys ENST00000342916.7:c.1633G>A 7:g.55163734G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1690841 1690841 1599108 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 106245193 c.1474A>C p.S492R Substitution - Missense het 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 22270724 surgery - NOS recurrent 64 ENSP00000342376.3:p.Ser492Arg ENST00000342916.7:c.1474A>C 7:g.55160314A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-EB-A431-01 2121600 1995836 skin NS NS NS malignant_melanoma NS NS NS y COSV51820698 COSM3639725 106251822 c.680C>T p.S227F Substitution - Missense 38 7:55152597-55152597 + - NEUTRAL .18615 Confirmed somatic variant 540 NS NS 34 ENSP00000342376.3:p.Ser227Phe ENST00000342916.7:c.680C>T 7:g.55152597C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-D3-A8GB-06 2262876 2129860 skin NS NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 106242422 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 540 NS NS 48 ENSP00000342376.3:p.Ser116Phe ENST00000342916.7:c.347C>T 7:g.55143411C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 587220 1766747 1671067 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51792177 COSM1205050 106242402 c.1279C>T p.R427C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 22895193 surgery fresh/frozen primary ENSP00000342376.3:p.Arg427Cys ENST00000342916.7:c.1279C>T 7:g.55157734C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 SJHYPO052-D 2590140 2451270 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 106242402 c.1279C>T p.R427C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 23334668 blood-bone marrow NS 16.3 ENSP00000342376.3:p.Arg427Cys ENST00000342916.7:c.1279C>T 7:g.55157734C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 WGC003608 2785119 2645235 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS y COSV99286188 COSM7420903 106261584 c.1570G>T p.V524F Substitution - Missense 38 7:55161570-55161570 + - .6767 Confirmed somatic variant 25526346 surgery fresh/frozen primary 54 ENSP00000342376.3:p.Val524Phe ENST00000342916.7:c.1570G>T 7:g.55161570G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2492701 2492701 2355316 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 106250485 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000342376.3:p.His47Tyr ENST00000342916.7:c.139C>T 7:g.55142336C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 MSU3-c 2809980 2666642 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV99292326 COSM9176305 106252565 c.1579C>T p.R527W Substitution - Missense 38 7:55161579-55161579 + - NEUTRAL .28879 Confirmed somatic variant 26336987 surgery fresh/frozen primary 51 ENSP00000342376.3:p.Arg527Trp ENST00000342916.7:c.1579C>T 7:g.55161579C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 R056-R1 2813482 2669874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289246 COSM8268187 106241264 c.788C>T p.T263I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 42 ENSP00000342376.3:p.Thr263Ile ENST00000342916.7:c.788C>T 7:g.55154051C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2014_Lung_sq_70_T 2744941 2603644 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 48 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GBM_IV-19 2354288 2218446 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-76-4927-01 2120379 1994615 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 58 ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51808387 COSM3412196 106247656 c.1793G>C p.G598A Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000342376.3:p.Gly598Ala ENST00000342916.7:c.1793G>C 7:g.55165350G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0000918-T01-IM3 2716255 2575076 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51799159 COSM747427 106250791 c.1766C>T p.P589L Substitution - Missense het 38 7:55165323-55165323 + - PATHOGENIC .95834 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Pro589Leu ENST00000342916.7:c.1766C>T 7:g.55165323C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006846-T01-IM5 2723226 2582047 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51781750 COSM6954369 106250522 c.954G>A p.M318I Substitution - Missense het 38 7:55155894-55155894 + - PATHOGENIC .91367 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Met318Ile ENST00000342916.7:c.954G>A 7:g.55155894G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S003577 1027697 944673 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 106239765 c.1787C>T p.P596L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Pro596Leu ENST00000342916.7:c.1787C>T 7:g.55165344C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-19-1789-01 2178219 2046517 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51850088 COSM2156010 106250777 c.1000C>T p.R334C Substitution - Missense 38 7:55155940-55155940 + - PATHOGENIC .91604 Confirmed somatic variant 329 NS NS 69 ENSP00000342376.3:p.Arg334Cys ENST00000342916.7:c.1000C>T 7:g.55155940C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 88 2630342 2490726 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51769145 COSM3266559 106255214 c.874G>A p.V292M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 27756406 surgery-fixed primary 48 ENSP00000342376.3:p.Val292Met ENST00000342916.7:c.874G>A 7:g.55154137G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-E1-A7YD-01 2386254 2249086 central_nervous_system brain NS NS glioma NS NS NS y COSV51785554 COSM21688 106239985 c.971G>T p.R324L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 545 NS primary 57 ENSP00000342376.3:p.Arg324Leu ENST00000342916.7:c.971G>T 7:g.55155911G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-46-3765-01 1781761 1685760 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51850921 COSM5982763 106246217 c.1879G>T p.G627W Substitution - Missense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 418 fresh/frozen - NOS primary 59 ENSP00000342376.3:p.Gly627Trp ENST00000342916.7:c.1879G>T 7:g.55165436G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2696517 2696517 2555421 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28201779 surgery fresh/frozen NS 60 ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CHG-98T 2634280 2494676 liver NS NS NS other neoplasm NS NS y COSV51850174 COSM6307834 106251112 c.350A>G p.Y117C Substitution - Missense 38 7:55143414-55143414 + - PATHOGENIC .98157 Confirmed somatic variant 660 NS primary 51 ENSP00000342376.3:p.Tyr117Cys ENST00000342916.7:c.350A>G 7:g.55143414A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-VS-A9UA-01 2386196 2249028 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99290048 COSM8641365 106255744 c.528G>C p.M176I Substitution - Missense 38 7:55146709-55146709 + - NEUTRAL .34467 Confirmed somatic variant 415 NS primary 60 ENSP00000342376.3:p.Met176Ile ENST00000342916.7:c.528G>C 7:g.55146709G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CRC177post 2730751 2589520 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51776247 COSM6110417 106247348 c.1393G>A p.G465R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Confirmed somatic variant 26416732 xenograft metastasis 59 ENSP00000342376.3:p.Gly465Arg ENST00000342916.7:c.1393G>A 7:g.55160233G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009661-T01-IM5 2725553 2584374 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003016-T01-IM3 2719225 2578046 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51839629 COSM6925694 106254673 c.389C>T p.T130I Substitution - Missense het 38 7:55143453-55143453 + - NEUTRAL .47678 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Thr130Ile ENST00000342916.7:c.389C>T 7:g.55143453C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-71-8520-01 2194759 2063037 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 417 NS NS 60 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2372112 2372112 2234905 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_III anaplastic NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 25694352 surgery fresh/frozen NS 28 ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0000918-T01-IM3 2716255 2575076 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 ILMN12 2816772 2673123 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV104369087 COSM9238851 106253679 c.1837G>A p.A613T Substitution - Missense 38 7:55165394-55165394 + - PATHOGENIC .87498 Confirmed somatic variant 29937994 surgery fresh/frozen NS 45 ENSP00000342376.3:p.Ala613Thr ENST00000342916.7:c.1837G>A 7:g.55165394G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51812540 COSM1451536 106248678 c.322A>G p.R108G Substitution - Missense 38 7:55143386-55143386 + - PATHOGENIC .72671 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000342376.3:p.Arg108Gly ENST00000342916.7:c.322A>G 7:g.55143386A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003456-T01-IM5 2719933 2578754 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 106242169 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg252Cys ENST00000342916.7:c.754C>T 7:g.55154017C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T1154 2296082 2161685 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51814845 COSM4680396 106266257 c.1697C>T p.A566V Substitution - Missense 38 7:55163798-55163798 + - NEUTRAL .08918 Confirmed somatic variant 25344691 NS NS 68.33 ENSP00000342376.3:p.Ala566Val ENST00000342916.7:c.1697C>T 7:g.55163798C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009451-T01-IM5 2725378 2584199 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51781835 COSM174732 106241611 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Glu114Lys ENST00000342916.7:c.340G>A 7:g.55143404G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-A2-A4S3-01 2187874 2056152 breast NS NS NS carcinoma NS NS NS y COSV51810209 COSM3833026 106241771 c.941A>G p.D314G Substitution - Missense 38 7:55155881-55155881 + - PATHOGENIC .96368 Confirmed somatic variant 414 NS NS 59 ENSP00000342376.3:p.Asp314Gly ENST00000342916.7:c.941A>G 7:g.55155881A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 106241217 c.910C>T p.H304Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000342376.3:p.His304Tyr ENST00000342916.7:c.910C>T 7:g.55155850C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 DUMC-18 2748715 2607418 central_nervous_system frontoparietal NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 29802247 surgery fresh/frozen NS 52 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0211-01 1910206 1798497 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 106241473 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 fresh/frozen - NOS primary 48 ENSP00000342376.3:p.Thr263Pro ENST00000342916.7:c.787A>C 7:g.55154050A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 YUOTHO 2439352 2302193 skin NS NS NS malignant_melanoma NS NS NS y COSV51848994 COSM5407724 106245867 c.1701G>A p.M567I Substitution - Missense het 38 7:55163802-55163802 + - PATHOGENIC .89204 Confirmed somatic variant 26214590 fresh/frozen - NOS primary 87 ENSP00000342376.3:p.Met567Ile ENST00000342916.7:c.1701G>A 7:g.55163802G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-CN-4742-01 2193489 2061767 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825459 COSM122789 106244524 c.1423A>G p.I475V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Confirmed somatic variant 627 NS NS 48 ENSP00000342376.3:p.Ile475Val ENST00000342916.7:c.1423A>G 7:g.55160263A>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 5-VS098-T1 2869935 2724932 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110457 COSM9807780 106252650 c.1165C>T p.P389S Substitution - Missense 38 7:55156790-55156790 + - PATHOGENIC .99297 Confirmed somatic variant 26950094 surgery - NOS NS 84 ENSP00000342376.3:p.Pro389Ser ENST00000342916.7:c.1165C>T 7:g.55156790C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-QH-A6XC-01 2263268 2130252 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS primary 48 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003456-T01-IM5 2719933 2578754 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0016773-T01-IM6 2830871 2686686 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV104577017 COSM9359622 106248498 c.743G>A p.C248Y Substitution - Missense 38 7:55152660-55152660 + - PATHOGENIC .99504 Confirmed somatic variant 30205045 surgery-fixed primary 77 ENSP00000342376.3:p.Cys248Tyr ENST00000342916.7:c.743G>A 7:g.55152660G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CH-LA8 2211434 2079637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51855488 COSM4166393 106246435 c.710C>T p.A237V Substitution - Missense 38 7:55152627-55152627 + - PATHOGENIC .99229 Confirmed somatic variant 24449147 surgery fresh/frozen NS 67 ENSP00000342376.3:p.Ala237Val ENST00000342916.7:c.710C>T 7:g.55152627C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DU-A5TY-01 2194202 2062480 central_nervous_system brain NS NS glioma NS NS NS y COSV51765897 COSM3929120 106262915 c.961G>T p.D321Y Substitution - Missense 38 7:55155901-55155901 + - PATHOGENIC .95198 Confirmed somatic variant 545 NS NS 46 ENSP00000342376.3:p.Asp321Tyr ENST00000342916.7:c.961G>T 7:g.55155901G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2372112 2372112 2234905 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_III anaplastic NS n COSV51822289 COSM42977 106250610 c.315G>T p.Q105H Substitution - Missense 38 7:55143379-55143379 + - PATHOGENIC .90579 Confirmed somatic variant 25694352 surgery fresh/frozen NS 28 ENSP00000342376.3:p.Gln105His ENST00000342916.7:c.315G>T 7:g.55143379G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 SJG-018 2561465 2422889 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS y COSV51850921 COSM5982763 106246217 c.1879G>T p.G627W Substitution - Missense 38 7:55165436-55165436 + - PATHOGENIC .99424 Confirmed somatic variant 27693639 short-term culture primary 79 ENSP00000342376.3:p.Gly627Trp ENST00000342916.7:c.1879G>T 7:g.55165436G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 23 2699404 2558308 skin NS NS NS malignant_melanoma NS NS NS n COSV51774288 COSM6906389 106245471 c.1256_1257delinsTT p.A419V Substitution - Missense het 38 7:55157711-55157712 + - Confirmed somatic variant 29420467 surgery-fixed NS ENSP00000342376.3:p.Ala419Val ENST00000342916.7:c.1256_1257delinsTT 7:g.55157711_55157712delinsTT EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0007076-T03-IM5 2723450 2582271 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS n COSV51860919 COSM6961890 106270689 c.593G>A p.S198N Substitution - Missense het 38 7:55151327-55151327 + - PATHOGENIC .89951 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Ser198Asn ENST00000342916.7:c.593G>A 7:g.55151327G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0005945-T01-IM5 2722328 2581149 haematopoietic_and_lymphoid_tissue lymph_node NS NS lymphoid_neoplasm follicular_lymphoma NS NS n COSV51837186 COSM1090861 106245627 c.442G>A p.V148M Substitution - Missense het 38 7:55146623-55146623 + - PATHOGENIC .99004 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000342376.3:p.Val148Met ENST00000342916.7:c.442G>A 7:g.55146623G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-B0-4822-01 2120426 1994662 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51848907 COSM3366976 106249707 c.976T>C p.C326R Substitution - Missense 38 7:55155916-55155916 + - PATHOGENIC .98755 Confirmed somatic variant 416 NS NS 78 ENSP00000342376.3:p.Cys326Arg ENST00000342916.7:c.976T>C 7:g.55155916T>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0000316-T01-IM3 2715020 2573841 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792237 COSM6842523 106244556 c.829_830delinsGA p.M277E Substitution - Missense het 38 7:55154092-55154093 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Met277Glu ENST00000342916.7:c.829_830delinsGA 7:g.55154092_55154093delinsGA EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T3174 2296192 2161795 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 106243472 c.1580G>A p.R527Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 25344691 NS NS 74.41 ENSP00000342376.3:p.Arg527Gln ENST00000342916.7:c.1580G>A 7:g.55161580G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0008257-T01-IM5 2724396 2583217 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766389 COSM43067 106251527 c.874G>T p.V292L Substitution - Missense het 38 7:55154137-55154137 + - PATHOGENIC .98997 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Val292Leu ENST00000342916.7:c.874G>T 7:g.55154137G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DU-8158-01 2194237 2062515 central_nervous_system brain NS NS glioma NS NS NS y COSV51771223 COSM3929114 106242577 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 545 NS NS 57 ENSP00000342376.3:p.Glu84Val ENST00000342916.7:c.251A>T 7:g.55143315A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003079-T01-IM5 2719588 2578409 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 SJHGG023_D 2307355 2172559 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 24705251 surgery - NOS NS 4 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-TM-A7C3-01 2262979 2129963 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 43 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-56-8304-01 2385872 2248704 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99294789 COSM8694245 106250879 c.259G>T p.G87C Substitution - Missense 38 7:55143323-55143323 + - PATHOGENIC .99526 Confirmed somatic variant 418 NS primary 73 ENSP00000342376.3:p.Gly87Cys ENST00000342916.7:c.259G>T 7:g.55143323G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-76-4926-01 2120378 1994614 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 68 ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003850-T01-IM5 2720342 2579163 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836185 COSM4884832 106253273 c.739G>T p.D247Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 660 NS primary 46 ENSP00000342376.3:p.Asp247Tyr ENST00000342916.7:c.739G>T 7:g.55152656G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 RS40M 2653649 2513771 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 106239429 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS metastasis 41.32 ENSP00000342376.3:p.Arg521Lys ENST00000342916.7:c.1562G>A 7:g.55161562G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CHG-13-09220T 2634310 2494706 liver NS NS NS other neoplasm NS NS y COSV51802176 COSM6258054 106269583 c.111G>T p.K37N Substitution - Missense 38 7:55142308-55142308 + - PATHOGENIC .84286 Confirmed somatic variant 660 NS primary 67 ENSP00000342376.3:p.Lys37Asn ENST00000342916.7:c.111G>T 7:g.55142308G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 DUMC-22 2748718 2607421 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51771223 COSM3929114 106242577 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 29802247 surgery fresh/frozen NS 62 ENSP00000342376.3:p.Glu84Val ENST00000342916.7:c.251A>T 7:g.55143315A>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0002265-T02-IM5 2719496 2578317 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009451-T01-IM5 2725378 2584199 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836251 COSM6348839 106253308 c.1527G>T p.L509F Substitution - Missense 38 7:55161527-55161527 + - PATHOGENIC .8964 Confirmed somatic variant 660 NS primary 46 ENSP00000342376.3:p.Leu509Phe ENST00000342916.7:c.1527G>T 7:g.55161527G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T1244 2658449 2518608 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 106243472 c.1580G>A p.R527Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 62.75 ENSP00000342376.3:p.Arg527Gln ENST00000342916.7:c.1580G>A 7:g.55161580G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0010864-T01-IM5 2726533 2585354 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51864573 COSM6977465 106243619 c.1117C>T p.P373S Substitution - Missense het 38 7:55156643-55156643 + - PATHOGENIC .91736 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Pro373Ser ENST00000342916.7:c.1117C>T 7:g.55156643C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0012360-T01-IM5 2727428 2586249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 106241002 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg108Lys ENST00000342916.7:c.323G>A 7:g.55143387G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-KT-A7W1-01 2262770 2129754 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 45 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 zcc203 2873641 2728634 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 33020650 surgery fresh/frozen NS ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-14-1827-01 2178235 2046533 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99295901 COSM7467664 106260905 c.368C>T p.S123F Substitution - Missense 38 7:55143432-55143432 + - PATHOGENIC .82087 Confirmed somatic variant 329 NS NS 51 ENSP00000342376.3:p.Ser123Phe ENST00000342916.7:c.368C>T 7:g.55143432C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 R074-I1 2813495 2669887 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 41 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-AR-A0TV-01 1779493 1683492 breast NS NS NS carcinoma NS NS NS y COSV99293406 COSM7679798 106255490 c.1577G>C p.C526S Substitution - Missense 38 7:55161577-55161577 + - PATHOGENIC .9951 Confirmed somatic variant 414 fresh/frozen - NOS primary 66 ENSP00000342376.3:p.Cys526Ser ENST00000342916.7:c.1577G>C 7:g.55161577G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2696711 2696711 2555615 oesophagus upper_third NS NS other metaplasia epidermoid NS n COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28731047 surgery-fixed primary 62 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GBM9-I2 2813459 2669851 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0005852-T02-IM5 2722238 2581059 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0009449-T01-IM5 2725376 2584197 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-AA-A00N-01 1651102 1565889 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51852585 COSM274945 106245035 c.926G>A p.R309Q Substitution - Missense 38 7:55155866-55155866 + - PATHOGENIC .98601 Confirmed somatic variant 22810696 376 NS NS 75 ENSP00000342376.3:p.Arg309Gln ENST00000342916.7:c.926G>A 7:g.55155866G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006952-T01-IM5 2723330 2582151 skin NS NS NS malignant_melanoma NS NS NS n COSV51774288 COSM6906389 106245471 c.1256_1257delinsTT p.A419V Substitution - Missense het 38 7:55157711-55157712 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Ala419Val ENST00000342916.7:c.1256_1257delinsTT 7:g.55157711_55157712delinsTT EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DU-5852-01 2194247 2062525 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 106242169 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS NS 61 ENSP00000342376.3:p.Arg252Cys ENST00000342916.7:c.754C>T 7:g.55154017C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-E1-A7YJ-01 2457421 2320258 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 106242169 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS primary 55 ENSP00000342376.3:p.Arg252Cys ENST00000342916.7:c.754C>T 7:g.55154017C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836217 COSM7314292 106253290 c.1414G>T p.A472S Substitution - Missense 38 7:55160254-55160254 + - PATHOGENIC .97432 Confirmed somatic variant 660 NS primary 46 ENSP00000342376.3:p.Ala472Ser ENST00000342916.7:c.1414G>T 7:g.55160254G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-FG-A87Q-01 2339613 2204596 central_nervous_system brain NS NS glioma NS NS NS y COSV99289246 COSM8268187 106241264 c.788C>T p.T263I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 545 NS primary 61 ENSP00000342376.3:p.Thr263Ile ENST00000342916.7:c.788C>T 7:g.55154051C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S04-45633-TP 2366567 2229450 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51801901 COSM4992959 106257454 c.448T>G p.F150V Substitution - Missense het 38 7:55146629-55146629 + - PATHOGENIC .92059 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000342376.3:p.Phe150Val ENST00000342916.7:c.448T>G 7:g.55146629T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-AA-3811-01 1651034 1565821 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 376 NS NS 84 ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0154 2107952 1985813 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0004666-T01-IM5 2721066 2579887 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 106245193 c.1474A>C p.S492R Substitution - Missense het 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000342376.3:p.Ser492Arg ENST00000342916.7:c.1474A>C 7:g.55160314A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 S001102 1027688 944664 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 106241473 c.787A>C p.T263P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000342376.3:p.Thr263Pro ENST00000342916.7:c.787A>C 7:g.55154050A>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-DU-7013-01 2194399 2062677 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 59 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-76-4931-01 2120382 1994618 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 70 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-HT-A5RC-01 2194260 2062538 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 70 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-12-0616 2108021 1985882 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 5-VS094-T1 2869927 2724924 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51776578 COSM4893368 106242422 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 26950094 surgery - NOS NS 84 ENSP00000342376.3:p.Ser116Phe ENST00000342916.7:c.347C>T 7:g.55143411C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0006876-T01-IM5 2723256 2582077 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-IQ-7630-01 2193638 2061916 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51792433 COSM6966446 106253906 c.1762G>A p.G588S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 627 NS NS 49 ENSP00000342376.3:p.Gly588Ser ENST00000342916.7:c.1762G>A 7:g.55165319G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-AA-3811-01 1651034 1565821 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51779162 COSM21689 106239765 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 376 NS NS 84 ENSP00000342376.3:p.Pro596Leu ENST00000342916.7:c.1787C>T 7:g.55165344C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0011503-T01-IM5 2727075 2585896 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 106247656 c.1793G>C p.G598A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Gly598Ala ENST00000342916.7:c.1793G>C 7:g.55165350G>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 CHC892T 2340454 2205437 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51853321 COSM3412170 106254910 c.478G>A p.E160K Substitution - Missense 38 7:55146659-55146659 + - PATHOGENIC .9774 Confirmed somatic variant 381 NS primary 72 ENSP00000342376.3:p.Glu160Lys ENST00000342916.7:c.478G>A 7:g.55146659G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 BC85-ctDNA 2668219 2527792 breast NS NS NS carcinoma NS NS NS y COSV51834499 COSM6845063 106240065 c.964G>A p.G322S Substitution - Missense het 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 27535334 circulating tumour metastasis ENSP00000342376.3:p.Gly322Ser ENST00000342916.7:c.964G>A 7:g.55155904G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P121 2072581 1951936 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51785554 COSM21688 106239985 c.971G>T p.R324L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 57.59 ENSP00000342376.3:p.Arg324Leu ENST00000342916.7:c.971G>T 7:g.55155911G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-GN-A266-06 2121796 1996032 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 106250485 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 540 NS NS 45 ENSP00000342376.3:p.His47Tyr ENST00000342916.7:c.139C>T 7:g.55142336C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-12-0656-01 2178172 2046470 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 106240722 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 NS NS 48 ENSP00000342376.3:p.Ala289Asp ENST00000342916.7:c.866C>A 7:g.55154129C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 Au2 2466841 2329672 skin scalp NS NS malignant_melanoma desmoplastic NS NS y COSV51779748 COSM3639716 106250485 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26343386 surgery fresh/frozen NS 85 ENSP00000342376.3:p.His47Tyr ENST00000342916.7:c.139C>T 7:g.55142336C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003702-T02-IM5 2829639 2685454 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51831642 COSM1496684 106245349 c.988G>A p.E330K Substitution - Missense 38 7:55155928-55155928 + - PATHOGENIC .94538 Confirmed somatic variant 30205045 surgery-fixed metastasis 50 ENSP00000342376.3:p.Glu330Lys ENST00000342916.7:c.988G>A 7:g.55155928G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0010107-T01-IM5 2725918 2584739 genital_tract extragonadal soft_tissue NS germ_cell_tumour yolk_sac_tumour NS NS n COSV51834570 COSM6972645 106244398 c.1855C>A p.L619M Substitution - Missense het 38 7:55165412-55165412 + - PATHOGENIC .9982 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000342376.3:p.Leu619Met ENST00000342916.7:c.1855C>A 7:g.55165412C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T660 2296260 2161863 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51781835 COSM174732 106241611 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 25344691 NS NS 66.58 ENSP00000342376.3:p.Glu114Lys ENST00000342916.7:c.340G>A 7:g.55143404G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0237 2107974 1985835 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 23917401 NS NS ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-TQ-A7RP-01 2457441 2320278 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 106242169 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS primary 66 ENSP00000342376.3:p.Arg252Cys ENST00000342916.7:c.754C>T 7:g.55154017C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-32-2632-01 2120352 1994588 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 106240523 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 329 NS NS 80 ENSP00000342376.3:p.Leu62Arg ENST00000342916.7:c.185T>G 7:g.55142382T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 1040346 1040346 956923 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_II NS NS n COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0000370-T01-IM3 2715141 2573962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51849071 COSM6910043 106265801 c.831_832delinsTT p.M277_D278delinsIY Substitution - Missense het 38 7:55154094-55154095 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Met277_Asp278delinsIleTyr ENST00000342916.7:c.831_832delinsTT 7:g.55154094_55154095delinsTT EGFR_ENST00000342916 ENST00000342916.7 1887 3236 R074-I1 2813495 2669887 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99297135 COSM9212199 106248557 c.865G>T p.A289S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 28263318 surgery fresh/frozen NS 41 ENSP00000342376.3:p.Ala289Ser ENST00000342916.7:c.865G>T 7:g.55154128G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0012194-T01-IM5 2727317 2586138 skin NS NS NS malignant_melanoma NS NS NS n COSV51860991 COSM6983544 106243288 c.97_98delinsAA p.G33N Substitution - Missense het 38 7:55142294-55142295 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Gly33Asn ENST00000342916.7:c.97_98delinsAA 7:g.55142294_55142295delinsAA EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0013010-T01-IM5 2803821 2660571 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51866279 COSM6926300 106241241 c.665G>A p.R222H Substitution - Missense het 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 29316426 surgery-fixed primary 64 ENSP00000342376.3:p.Arg222His ENST00000342916.7:c.665G>A 7:g.55152582G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 I2L-P16-Tumor-Organoid 2433496 2296377 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51814923 COSM5358036 106242002 c.559T>C p.C187R Substitution - Missense het 38 7:55146740-55146740 + - PATHOGENIC .98691 Confirmed somatic variant 25957691 NS NS 67 ENSP00000342376.3:p.Cys187Arg ENST00000342916.7:c.559T>C 7:g.55146740T>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 zcc203 2873641 2728634 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS y COSV99297135 COSM9212199 106248557 c.865G>T p.A289S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 33020650 surgery fresh/frozen NS ENSP00000342376.3:p.Ala289Ser ENST00000342916.7:c.865G>T 7:g.55154128G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-BT-A42E-01 2193275 2061553 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51814701 COSM7084541 106240229 c.361G>T p.V121F Substitution - Missense 38 7:55143425-55143425 + - PATHOGENIC .99041 Confirmed somatic variant 413 NS NS 74 ENSP00000342376.3:p.Val121Phe ENST00000342916.7:c.361G>T 7:g.55143425G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GBM9-I2 2813459 2669851 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0005303-T01-IM5 2721704 2580525 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51769031 COSM21690 106239081 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000342376.3:p.Gly598Val ENST00000342916.7:c.1793G>T 7:g.55165350G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 EOPC-126_tumor_01 2633717 2494113 prostate NS NS NS carcinoma NS NS NS y COSV51793336 COSM6214981 106255345 c.1663T>C p.C555R Substitution - Missense 38 7:55163764-55163764 + - PATHOGENIC .99407 Confirmed somatic variant 534 NS primary 47 ENSP00000342376.3:p.Cys555Arg ENST00000342916.7:c.1663T>C 7:g.55163764T>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-26-5139-01 2120327 1994563 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51856614 COSM3412172 106261022 c.668G>A p.C223Y Substitution - Missense 38 7:55152585-55152585 + - PATHOGENIC .99676 Confirmed somatic variant 329 NS NS 65 ENSP00000342376.3:p.Cys223Tyr ENST00000342916.7:c.668G>A 7:g.55152585G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 2492700 2492700 2355315 skin face NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 106250485 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen primary ENSP00000342376.3:p.His47Tyr ENST00000342916.7:c.139C>T 7:g.55142336C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0011293-T01-IM5 2726897 2585718 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51862653 COSM6980033 106239552 c.1800G>T p.M600I Substitution - Missense het 38 7:55165357-55165357 + - PATHOGENIC .94832 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Met600Ile ENST00000342916.7:c.1800G>T 7:g.55165357G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-A8-A094-01 1779383 1683382 breast NS NS NS carcinoma NS NS NS y COSV51768800 COSM6499385 106249647 c.844G>A p.E282K Substitution - Missense 38 7:55154107-55154107 + - PATHOGENIC .81806 Confirmed somatic variant 414 fresh/frozen - NOS primary 75 ENSP00000342376.3:p.Glu282Lys ENST00000342916.7:c.844G>A 7:g.55154107G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003068-T01-IM5 2719577 2578398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51843270 COSM6926023 106250616 c.1088C>A p.T363N Substitution - Missense het 38 7:55156614-55156614 + - PATHOGENIC .99429 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Thr363Asn ENST00000342916.7:c.1088C>A 7:g.55156614C>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 17218 1423801 1333829 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51785911 COSM48912 106266786 c.1351_1352delinsTT p.R451F Substitution - Missense het 38 7:55160191-55160192 + - Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000342376.3:p.Arg451Phe ENST00000342916.7:c.1351_1352delinsTT 7:g.55160191_55160192delinsTT EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-06-0878-01 1337866 1248251 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 106239208 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 74 ENSP00000342376.3:p.Ala289Thr ENST00000342916.7:c.865G>A 7:g.55154128G>A EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-4W-AA9T-01 2339571 2204554 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 106241040 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS primary 54 ENSP00000342376.3:p.Ala289Val ENST00000342916.7:c.866C>T 7:g.55154129C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T116 2658237 2518396 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51787894 COSM6652229 106254609 c.84G>T p.K28N Substitution - Missense 38 7:55019361-55019361 + - NEUTRAL .32765 Confirmed somatic variant 27149842 NS NS 52.58 ENSP00000342376.3:p.Lys28Asn ENST00000342916.7:c.84G>T 7:g.55019361G>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 P-0003170-T01-IM5 2719663 2578484 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51841905 COSM6926730 106240917 c.931T>C p.C311R Substitution - Missense het 38 7:55155871-55155871 + - PATHOGENIC .98694 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000342376.3:p.Cys311Arg ENST00000342916.7:c.931T>C 7:g.55155871T>C EGFR_ENST00000342916 ENST00000342916.7 1887 3236 GB052T 2634017 2494413 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 106239602 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 672 NS primary ENSP00000342376.3:p.Arg222Cys ENST00000342916.7:c.664C>T 7:g.55152581C>T EGFR_ENST00000342916 ENST00000342916.7 1887 3236 T116 2658237 2518396 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51773524 COSM1090858 106240218 c.418T>G p.L140V Substitution - Missense 38 7:55143482-55143482 + - NEUTRAL .25717 Confirmed somatic variant 27149842 NS NS 52.58 ENSP00000342376.3:p.Leu140Val ENST00000342916.7:c.418T>G 7:g.55143482T>G EGFR_ENST00000342916 ENST00000342916.7 1887 3236 TCGA-A7-A6VX-01 2262909 2129893 breast NS NS NS carcinoma NS NS NS y COSV99294439 COSM7672524 106250048 c.439G>A p.A147T Substitution - Missense 38 7:55146620-55146620 + - PATHOGENIC .9897 Confirmed somatic variant 414 NS primary 68 ENSP00000342376.3:p.Ala147Thr ENST00000342916.7:c.439G>A 7:g.55146620G>A DUSP8_ENST00000331588 ENST00000331588.4 1878 3074 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV104645104 COSM9385824 104077169 c.754C>T p.R252C Substitution - Missense 38 11:1557861-1557861 - - PATHOGENIC .93808 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000329539.4:p.Arg252Cys ENST00000331588.4:c.754C>T 11:g.1557861G>A SCN3A_ENST00000639244 ENST00000639244.1 5940 10590 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105872781 COSM10012800 173398778 c.5462T>A p.V1821D Substitution - Missense 38 2:165090628-165090628 - - PATHOGENIC .99267 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000492251.1:p.Val1821Asp ENST00000639244.1:c.5462T>A 2:g.165090628A>T SMOX_ENST00000305958 ENST00000305958.8 1668 15862 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105846220 COSM10009557 104079031 c.841C>T p.R281W Substitution - Missense 38 20:4182320-4182320 + - .51649 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000307252.4:p.Arg281Trp ENST00000305958.8:c.841C>T 20:g.4182320C>T IFT22_ENST00000621899 ENST00000621899.4 327 21895 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105876048 COSM10012944 169917130 c.16G>A p.G6R Substitution - Missense 38 7:101316502-101316502 - - PATHOGENIC .98716 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000478948.1:p.Gly6Arg ENST00000621899.4:c.16G>A 7:g.101316502C>T FBXL7_ENST00000329673 ENST00000329673.8 1350 13604 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV61649228 COSM5743062 102428821 c.1010G>A p.R337H Substitution - Missense 38 5:15936846-15936846 + - PATHOGENIC .98974 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000329632.8:p.Arg337His ENST00000329673.8:c.1010G>A 5:g.15936846G>A CEP170_ENST00000366544 ENST00000366544.5 4461 28920 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105907111 COSM10012879 110612886 c.1708G>A p.E570K Substitution - Missense 38 1:243165958-243165958 - - PATHOGENIC .98958 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000355502.1:p.Glu570Lys ENST00000366544.5:c.1708G>A 1:g.243165958C>T CEP170 ENST00000366542.5 4755 28920 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105907111 COSM10012879 110583004 c.2002G>A p.E668K Substitution - Missense 38 1:243165958-243165958 - - PATHOGENIC .98958 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000355500.1:p.Glu668Lys ENST00000366542.5:c.2002G>A 1:g.243165958C>T OR56A1_ENST00000641900 ENST00000641900.1 945 14781 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105883756 COSM10012845 175657042 c.755T>G p.L252R Substitution - Missense 38 11:6026938-6026938 - - NEUTRAL .24245 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000493047.1:p.Leu252Arg ENST00000641900.1:c.755T>G 11:g.6026938A>C TFAP2A_ENST00000319516 ENST00000319516.8 1302 11742 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105902772 COSM10012977 102323984 c.709C>A p.P237T Substitution - Missense 38 6:10404551-10404551 - - PATHOGENIC .96956 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000316516.4:p.Pro237Thr ENST00000319516.8:c.709C>A 6:g.10404551G>T ZFYVE9_ENST00000357206 ENST00000357206.6 4101 6775 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV55095322 COSM910631 110778998 c.3220C>T p.R1074W Substitution - Missense 38 1:52303884-52303884 + - PATHOGENIC .76999 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000349737.2:p.Arg1074Trp ENST00000357206.6:c.3220C>T 1:g.52303884C>T SYNE1_ENST00000423061 ENST00000423061.5 26250 17089 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV55014875 COSM7191704 123577119 c.17945G>A p.R5982Q Substitution - Missense 38 6:152284027-152284027 - - PATHOGENIC .98502 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000396024.1:p.Arg5982Gln ENST00000423061.5:c.17945G>A 6:g.152284027C>T SPTBN1 ENST00000356805.8 7095 11275 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105886037 COSM10012863 109451196 c.1396G>T p.A466S Substitution - Missense 38 2:54625986-54625986 + - PATHOGENIC .98456 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000349259.4:p.Ala466Ser ENST00000356805.8:c.1396G>T 2:g.54625986G>T CEP350 ENST00000367607.7 9354 24238 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105925942 COSM10012812 108446124 c.1522C>G p.L508V Substitution - Missense 38 1:180013975-180013975 + - PATHOGENIC .9726 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000356579.3:p.Leu508Val ENST00000367607.7:c.1522C>G 1:g.180013975C>G SORCS3 ENST00000369701.7 3669 16699 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV100865131 COSM8262438 111267854 c.644C>T p.T215M Substitution - Missense 38 10:104842808-104842808 + - PATHOGENIC .95333 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000358715.3:p.Thr215Met ENST00000369701.7:c.644C>T 10:g.104842808C>T CHN1_ENST00000295497 ENST00000295497.11 1005 1943 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105886981 COSM10012859 99814371 c.949C>T p.R317W Substitution - Missense 38 2:174800172-174800172 - - PATHOGENIC .98155 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000295497.7:p.Arg317Trp ENST00000295497.11:c.949C>T 2:g.174800172G>A RASGRF1_ENST00000558480 ENST00000558480.6 3774 9875 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105938097 COSM10012910 157983958 c.850G>A p.D284N Substitution - Missense 38 15:79046774-79046774 - - PATHOGENIC .915 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000452781.2:p.Asp284Asn ENST00000558480.6:c.850G>A 15:g.79046774C>T POLR1A ENST00000263857.10 5163 17264 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105848950 COSM10012940 98506144 c.4666A>T p.T1556S Substitution - Missense 38 2:86030309-86030309 - - PATHOGENIC .96985 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000263857.6:p.Thr1556Ser ENST00000263857.10:c.4666A>T 2:g.86030309T>A SEZ6_ENST00000360295 ENST00000360295.13 2982 15955 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105887926 COSM10012920 107941507 c.1904T>C p.I635T Substitution - Missense 38 17:28959340-28959340 - - PATHOGENIC .9935 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000353440.9:p.Ile635Thr ENST00000360295.13:c.1904T>C 17:g.28959340A>G TAF4B ENST00000578121.5 2604 11538 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105870114 COSM10012788 160679923 c.877C>T p.L293F Substitution - Missense 38 18:26275048-26275048 + - PATHOGENIC .92408 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000462980.1:p.Leu293Phe ENST00000578121.5:c.877C>T 18:g.26275048C>T KIFC3_ENST00000445690 ENST00000445690.6 2481 6326 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65551650 COSM971903 127246497 c.694C>T p.R232W Substitution - Missense 38 16:57771269-57771269 - - PATHOGENIC .87712 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000401696.2:p.Arg232Trp ENST00000445690.6:c.694C>T 16:g.57771269G>A MTSS1L_ENST00000616026 ENST00000616026.4 2241 25094 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105912132 COSM10012770 169341291 c.953G>A p.R318H Substitution - Missense 38 16:70674403-70674403 - - PATHOGENIC .95665 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000481169.1:p.Arg318His ENST00000616026.4:c.953G>A 16:g.70674403C>T CEACAM20_ENST00000621342 ENST00000621342.4 1758 24879 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105885448 COSM10012840 168849364 c.211T>C p.S71P Substitution - Missense 38 19:44524247-44524247 - - NEUTRAL .07541 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000480940.1:p.Ser71Pro ENST00000621342.4:c.211T>C 19:g.44524247A>G GFOD1_ENST00000379284 ENST00000379284.1 864 21096 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV64954773 COSM6670542 116090045 c.811G>A p.A271T Substitution - Missense 38 6:13364796-13364796 - - PATHOGENIC .98237 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000368586.1:p.Ala271Thr ENST00000379284.1:c.811G>A 6:g.13364796C>T ZNF334_ENST00000593880 ENST00000593880.1 2112 15806 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV61619438 COSM1027463 166762769 c.1982G>A p.R661H Substitution - Missense 38 20:46501426-46501426 - - NEUTRAL .00039 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000473194.1:p.Arg661His ENST00000593880.1:c.1982G>A 20:g.46501426C>T SORCS3_ENST00000369699 ENST00000369699.8 3669 16699 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV100865131 COSM8262438 111203838 c.644C>T p.T215M Substitution - Missense 38 10:104842808-104842808 + - PATHOGENIC .95333 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000358713.5:p.Thr215Met ENST00000369699.8:c.644C>T 10:g.104842808C>T WIPF3_ENST00000409290 ENST00000409290.1 1452 22004 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105840339 COSM10012942 120555300 c.286C>A p.P96T Substitution - Missense 38 7:29879071-29879071 + - PATHOGENIC .95711 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000386878.1:p.Pro96Thr ENST00000409290.1:c.286C>A 7:g.29879071C>A PTPDC1_ENST00000375360 ENST00000375360.7 2265 30184 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105860297 COSM10012886 112677543 c.398C>T p.P133L Substitution - Missense 38 9:94088207-94088207 + - PATHOGENIC .9798 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000364509.3:p.Pro133Leu ENST00000375360.7:c.398C>T 9:g.94088207C>T ITGA11_ENST00000423218 ENST00000423218.6 3570 6136 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105878574 COSM10012779 124082596 c.2947G>A p.G983R Substitution - Missense 38 15:68312799-68312799 - - PATHOGENIC .94772 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000403392.2:p.Gly983Arg ENST00000423218.6:c.2947G>A 15:g.68312799C>T ZNF385D ENST00000281523.7 1188 26191 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105859702 COSM10012925 102661490 c.689C>A p.T230N Substitution - Missense 38 3:21425655-21425655 - - PATHOGENIC .98456 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000281523.2:p.Thr230Asn ENST00000281523.7:c.689C>A 3:g.21425655G>T XIRP1 ENST00000340369.3 5532 14301 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105903954 COSM10012815 106002913 c.25G>C p.A9P Substitution - Missense 38 3:39189421-39189421 - - PATHOGENIC .72584 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000343140.3:p.Ala9Pro ENST00000340369.3:c.25G>C 3:g.39189421C>G ZNF777 ENST00000247930.4 2496 22213 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105854384 COSM10012799 100350317 c.1888G>A p.G630S Substitution - Missense 38 7:149432384-149432384 - - .59556 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000247930.4:p.Gly630Ser ENST00000247930.4:c.1888G>A 7:g.149432384C>T LINGO1 ENST00000355300.6 1863 21205 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV100796453 COSM8304855 109787345 c.1636G>A p.A546T Substitution - Missense 38 15:77614271-77614271 - - PATHOGENIC .96149 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000347451.6:p.Ala546Thr ENST00000355300.6:c.1636G>A 15:g.77614271C>T MUC16 ENST00000397910.8 43524 15582 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105934438 COSM10012962 121389478 c.39043C>G p.L13015V Substitution - Missense 38 19:8899007-8899007 - - NEUTRAL .03244 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000381008.2:p.Leu13015Val ENST00000397910.8:c.39043C>G 19:g.8899007G>C F7 ENST00000375581.3 1401 3544 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105916177 COSM10012857 113369052 c.823G>A p.E275K Substitution - Missense 38 13:113118430-113118430 + - NEUTRAL .06932 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000364731.3:p.Glu275Lys ENST00000375581.3:c.823G>A 13:g.113118430G>A TDRD7 ENST00000355295.4 3297 30831 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105912556 COSM10012814 109777058 c.3229C>T p.P1077S Substitution - Missense 38 9:97495815-97495815 + - PATHOGENIC .91555 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000347444.4:p.Pro1077Ser ENST00000355295.4:c.3229C>T 9:g.97495815C>T MYH6 ENST00000405093.7 5820 7576 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105908359 COSM10012806 120447716 c.3346C>T p.R1116C Substitution - Missense 38 14:23390443-23390443 - - PATHOGENIC .98819 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000386041.3:p.Arg1116Cys ENST00000405093.7:c.3346C>T 14:g.23390443G>A KIAA0100_ENST00000389003 ENST00000389003.7 6279 28960 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV101197296 COSM8902986 114638016 c.2741G>A p.R914H Substitution - Missense 38 17:28633987-28633987 - - PATHOGENIC .83007 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000467716.1:p.Arg914His ENST00000389003.7:c.2741G>A 17:g.28633987C>T IFT22_ENST00000437644 ENST00000437644.2 468 21895 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105876048 COSM10012944 128010193 c.157G>A p.G53R Substitution - Missense 38 7:101316502-101316502 - - PATHOGENIC .98716 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000390770.2:p.Gly53Arg ENST00000437644.2:c.157G>A 7:g.101316502C>T XIRP1_ENST00000396251 ENST00000396251.1 3366 14301 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105903954 COSM10012815 120918660 c.25G>C p.A9P Substitution - Missense 38 3:39189421-39189421 - - PATHOGENIC .72584 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000379550.1:p.Ala9Pro ENST00000396251.1:c.25G>C 3:g.39189421C>G ADAM18_ENST00000379866 ENST00000379866.5 2148 196 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105848019 COSM10012907 113660699 c.1082C>A p.P361Q Substitution - Missense 38 8:39648451-39648451 + - NEUTRAL .02606 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000369195.1:p.Pro361Gln ENST00000379866.5:c.1082C>A 8:g.39648451C>A CHD9 ENST00000447540.5 8694 25701 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105871502 COSM10012854 129885418 c.7119A>C p.E2373D Substitution - Missense 38 16:53308751-53308751 + - PATHOGENIC .86656 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000396345.2:p.Glu2373Asp ENST00000447540.5:c.7119A>C 16:g.53308751A>C BIRC6 ENST00000421745.6 14574 13516 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105933546 COSM10012797 123982846 c.12172G>A p.D4058N Substitution - Missense 38 2:32531432-32531432 + - PATHOGENIC .99284 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000393596.2:p.Asp4058Asn ENST00000421745.6:c.12172G>A 2:g.32531432G>A OR10K1_ENST00000289451 ENST00000289451.4 942 14693 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV56872727 COSM5698964 102415879 c.346G>T p.A116S Substitution - Missense 38 1:158465907-158465907 + - .50134 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000289451.2:p.Ala116Ser ENST00000289451.4:c.346G>T 1:g.158465907G>T IARS ENST00000375643.7 3789 5330 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105927180 COSM10012856 113539176 c.1552C>T p.H518Y Substitution - Missense 38 9:92265077-92265077 - - PATHOGENIC .91051 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000364794.3:p.His518Tyr ENST00000375643.7:c.1552C>T 9:g.92265077G>A CEP170_ENST00000366543 ENST00000366543.5 4383 28920 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105907111 COSM10012879 110597457 c.1708G>A p.E570K Substitution - Missense 38 1:243165958-243165958 - - PATHOGENIC .98958 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000355501.1:p.Glu570Lys ENST00000366543.5:c.1708G>A 1:g.243165958C>T ABCC8_ENST00000646902 ENST00000646902.1 4713 59 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105879570 COSM10012873 176811458 c.2054T>C p.F685S Substitution - Missense 38 11:17427926-17427926 - - PATHOGENIC .98111 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000494101.1:p.Phe685Ser ENST00000646902.1:c.2054T>C 11:g.17427926A>G SLC4A4 ENST00000425175.5 3285 11030 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV52623703 COSM420534 124382524 c.2308G>A p.V770I Substitution - Missense 38 4:71534254-71534254 + - PATHOGENIC .91286 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000393557.1:p.Val770Ile ENST00000425175.5:c.2308G>A 4:g.71534254G>A PCARE ENST00000331664.5 3867 34383 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105895380 COSM10012841 104103694 c.3638C>A p.T1213N Substitution - Missense 38 2:29070624-29070624 - - NEUTRAL .04832 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000332809.4:p.Thr1213Asn ENST00000331664.5:c.3638C>A 2:g.29070624G>T KIFC3_ENST00000379655 ENST00000379655.8 2502 6326 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65551650 COSM971903 113045668 c.694C>T p.R232W Substitution - Missense 38 16:57771269-57771269 - - PATHOGENIC .87712 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000368976.4:p.Arg232Trp ENST00000379655.8:c.694C>T 16:g.57771269G>A TRMT10B_ENST00000377753 ENST00000377753.6 690 26454 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105877142 COSM10012898 115315018 c.368G>C p.S123T Substitution - Missense 38 9:37769969-37769969 + - .6772 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000366982.2:p.Ser123Thr ENST00000377753.6:c.368G>C 9:g.37769969G>C ABCC8_ENST00000643878 ENST00000643878.1 4749 59 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105879570 COSM10012873 177156572 c.2057T>C p.F686S Substitution - Missense 38 11:17427926-17427926 - - PATHOGENIC .98111 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000495271.1:p.Phe686Ser ENST00000643878.1:c.2057T>C 11:g.17427926A>G SPTBN1_ENST00000615901 ENST00000615901.4 7101 11275 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105886037 COSM10012863 168584137 c.1396G>T p.A466S Substitution - Missense 38 2:54625986-54625986 + - PATHOGENIC .98456 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000479037.1:p.Ala466Ser ENST00000615901.4:c.1396G>T 2:g.54625986G>T PLCL2_ENST00000432376 ENST00000432376.5 3006 9064 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105936602 COSM10012889 128736841 c.1796G>T p.G599V Substitution - Missense 38 3:17011520-17011520 + - PATHOGENIC .9886 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000412836.1:p.Gly599Val ENST00000432376.5:c.1796G>T 3:g.17011520G>T LILRA6_ENST00000245621 ENST00000245621.6 1395 15495 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105838079 COSM10012776 99824309 c.787G>T p.D263Y Substitution - Missense 38 19:54240999-54240999 - - NEUTRAL .0038 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000245621.4:p.Asp263Tyr ENST00000245621.6:c.787G>T 19:g.54240999C>A FZD10_ENST00000539839 ENST00000539839.1 1365 4039 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57472788 COSM4040107 151399189 c.400G>A p.A134T Substitution - Missense 38 12:130163440-130163440 + - NEUTRAL .27659 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000438460.1:p.Ala134Thr ENST00000539839.1:c.400G>A 12:g.130163440G>A NAGPA ENST00000312251.7 1548 17378 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105888740 COSM10012899 105417009 c.482G>A p.S161N Substitution - Missense 38 16:5033333-5033333 - - NEUTRAL .21709 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000310998.3:p.Ser161Asn ENST00000312251.7:c.482G>A 16:g.5033333C>T MTCL1_ENST00000517570 ENST00000517570.5 4638 29121 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV60406354 COSM5665008 146766484 c.1081G>A p.A361T Substitution - Missense 38 18:8784193-8784193 + - PATHOGENIC .91329 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000429556.1:p.Ala361Thr ENST00000517570.5:c.1081G>A 18:g.8784193G>A BRAF_ENST00000288602 ENST00000288602.11 2421 1097 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV56056643 COSM476 101859942 c.1919T>A p.V640E Substitution - Missense 38 7:140753336-140753336 - - PATHOGENIC .98542 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000288602.7:p.Val640Glu ENST00000288602.11:c.1919T>A 7:g.140753336A>T IARS_ENST00000447699 ENST00000447699.6 3459 5330 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105927180 COSM10012856 130164732 c.1222C>T p.H408Y Substitution - Missense 38 9:92265077-92265077 - - PATHOGENIC .91051 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000415020.2:p.His408Tyr ENST00000447699.6:c.1222C>T 9:g.92265077G>A SCN2A_ENST00000636985 ENST00000636985.2 5622 10588 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105873046 COSM10012780 171194063 c.4892C>A p.S1631Y Substitution - Missense 38 2:165389094-165389094 + - PATHOGENIC .98186 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000490849.1:p.Ser1631Tyr ENST00000636985.2:c.4892C>A 2:g.165389094C>A GLIPR2 ENST00000377960.8 465 18007 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105927447 COSM10012961 116310878 c.73G>A p.G25S Substitution - Missense 38 9:36147845-36147845 + - .67561 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000367196.4:p.Gly25Ser ENST00000377960.8:c.73G>A 9:g.36147845G>A GREB1 ENST00000381486.6 5850 24885 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV52193807 COSM5010782 114034134 c.5743C>T p.R1915C Substitution - Missense 38 2:11640347-11640347 + - PATHOGENIC .81416 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000370896.2:p.Arg1915Cys ENST00000381486.6:c.5743C>T 2:g.11640347C>T GREB1_ENST00000234142 ENST00000234142.9 5850 24885 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV52193807 COSM5010782 97071924 c.5743C>T p.R1915C Substitution - Missense 38 2:11640347-11640347 + - PATHOGENIC .81416 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000234142.5:p.Arg1915Cys ENST00000234142.9:c.5743C>T 2:g.11640347C>T GLIPR2_ENST00000396613 ENST00000396613.7 189 18007 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105927447 COSM10012961 117175865 c.73G>A p.G25S Substitution - Missense 38 9:36147845-36147845 + - .67561 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000379857.4:p.Gly25Ser ENST00000396613.7:c.73G>A 9:g.36147845G>A TTN_ENST00000460472 ENST00000460472.6 80781 12403 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105912072 COSM10012820 132440336 c.9405A>T p.K3135N Substitution - Missense 38 2:178766541-178766541 - - PATHOGENIC .90433 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000434586.1:p.Lys3135Asn ENST00000460472.6:c.9405A>T 2:g.178766541T>A SYNE1 ENST00000367255.9 26394 17089 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV55014875 COSM7191704 111263394 c.18158G>A p.R6053Q Substitution - Missense 38 6:152284027-152284027 - - PATHOGENIC .98502 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000356224.5:p.Arg6053Gln ENST00000367255.9:c.18158G>A 6:g.152284027C>T P2RX3 ENST00000263314.2 1194 8534 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105840384 COSM10012941 97430298 c.1001T>A p.V334E Substitution - Missense 38 11:57368436-57368436 + - PATHOGENIC .96172 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000263314.2:p.Val334Glu ENST00000263314.2:c.1001T>A 11:g.57368436T>A TTN_ENST00000460472 ENST00000460472.6 80781 12403 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV59957361 COSM130006 132531292 c.184C>T p.R62C Substitution - Missense 38 2:178802249-178802249 - - PATHOGENIC .99021 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000434586.1:p.Arg62Cys ENST00000460472.6:c.184C>T 2:g.178802249G>A EGFR ENST00000275493.6 3633 3236 1729750 1729750 1635721 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM255174 178384606 c.? p.R836S Substitution - Missense + - Variant of unknown origin 22805266 NS NS ENSP00000275493.2:p.Arg836Ser EGFR ENST00000275493.6 3633 3236 1246735 1246735 1158414 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 19692680 surgery - NOS NS EGFR ENST00000275493.6 3633 3236 1097636 1097636 1012297 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26412 178384237 c.? p.G779S Substitution - Missense + - Variant of unknown origin 18172267 surgery-fixed NS ENSP00000275493.2:p.Gly779Ser EGFR ENST00000275493.6 3633 3236 1542363 1542363 1464666 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 21782507 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2778595 2778595 2636649 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV99294037 COSM7410343 99402035 c.2621G>A p.G874D Substitution - Missense 38 7:55191870-55191870 + - PATHOGENIC .98912 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000275493.2:p.Gly874Asp ENST00000275493.6:c.2621G>A 7:g.55191870G>A EGFR ENST00000275493.6 3633 3236 2693326 2693326 2552245 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSM20894 178379162 c.? p.A859T Substitution - Missense + - Variant of unknown origin 28062544 surgery-fixed metastasis ENSP00000275493.2:p.Ala859Thr EGFR ENST00000275493.6 3633 3236 2770725 2770725 2628926 lung NS NS NS carcinoma invasive_mucinous_adenocarcinoma NS NS n COSM7343438 178380806 c.? p.E868K Substitution - Missense + - Variant of unknown origin 25403583 surgery-fixed NS 68 ENSP00000275493.2:p.Glu868Lys EGFR ENST00000275493.6 3633 3236 1856000 1856000 1748553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26411 178380422 c.? p.S720F Substitution - Missense + - Variant of unknown origin 23337026 fixed - NOS primary ENSP00000275493.2:p.Ser720Phe EGFR ENST00000275493.6 3633 3236 2733214 2733214 2591967 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827210 COSM7002282 99376208 c.3485G>A p.S1162N Substitution - Missense 38 7:55205469-55205469 + - NEUTRAL .08134 Variant of unknown origin 28855349 surgery - NOS recurrent 55 ENSP00000275493.2:p.Ser1162Asn ENST00000275493.6:c.3485G>A 7:g.55205469G>A EGFR ENST00000275493.6 3633 3236 2432389 2432389 2295292 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM4603655 178382423 c.? p.V765M Substitution - Missense + - Variant of unknown origin 26462025 surgery - NOS metastasis ENSP00000275493.2:p.Val765Met EGFR ENST00000275493.6 3633 3236 2345108 2345108 2209780 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2862107 2862107 2717309 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV105111081 COSM9572577 99384873 c.1453G>A p.G485S Substitution - Missense 38 7:55160293-55160293 + - NEUTRAL .00282 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000275493.2:p.Gly485Ser ENST00000275493.6:c.1453G>A 7:g.55160293G>A EGFR ENST00000275493.6 3633 3236 2345121 2345121 2209793 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1875147 1875147 1765738 salivary_gland parotid NS NS carcinoma NS NS NS n COSM1235287 178378214 c.? p.D770N Substitution - Missense + - Variant of unknown origin 23139256 fixed - NOS NS ENSP00000275493.2:p.Asp770Asn EGFR ENST00000275493.6 3633 3236 1667720 1667720 1581013 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM219790 178387709 c.? p.H805Y Substitution - Missense + - Variant of unknown origin 22528563 NS NS EGFR ENST00000275493.6 3633 3236 2840810 2840810 2696370 prostate NS NS NS carcinoma NS NS NS n COSV104577207 COSM9493802 99460410 c.686G>A p.S229N Substitution - Missense 38 7:55152603-55152603 + - PATHOGENIC .9474 Variant of unknown origin 31874108 surgery-fixed metastasis ENSP00000275493.2:p.Ser229Asn ENST00000275493.6:c.686G>A 7:g.55152603G>A EGFR ENST00000275493.6 3633 3236 2595757 2595757 2456633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 27538584 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1284674 1284674 1195969 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM34160 178383469 c.? p.R831C Substitution - Missense + - Variant of unknown origin 16467085 surgery - NOS NS ENSP00000275493.2:p.Arg831Cys EGFR ENST00000275493.6 3633 3236 2096190 2096190 1974254 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 2344979 2344979 2209651 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 TCGA-D1-A15W-01 1783496 1687495 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51815247 COSM1090893 99376673 c.2750G>C p.G917A Substitution - Missense hom 38 7:55198765-55198765 + - PATHOGENIC .98646 Variant of unknown origin 419 fresh/frozen - NOS primary 58 ENSP00000275493.2:p.Gly917Ala ENST00000275493.6:c.2750G>C 7:g.55198765G>C EGFR ENST00000275493.6 3633 3236 1672417 1672417 1585471 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM24862 178381344 c.? p.I706T Substitution - Missense + - Variant of unknown origin 21729655 fine needle aspirate metastasis 45 EGFR ENST00000275493.6 3633 3236 1964225 1964225 1850760 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM255169 178381173 c.? p.R705K Substitution - Missense + - Variant of unknown origin 23749122 NS NS EGFR ENST00000275493.6 3633 3236 1875146 1875146 1765737 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSM1235286 178386257 c.? p.E804K Substitution - Missense + - Variant of unknown origin 23139256 fixed - NOS NS ENSP00000275493.2:p.Glu804Lys EGFR ENST00000275493.6 3633 3236 5-GE067-T1 2869773 2724770 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51802062 COSM6008937 99385308 c.659C>T p.S220F Substitution - Missense 38 7:55152576-55152576 + - PATHOGENIC .98424 Variant of unknown origin 26950094 surgery - NOS NS ENSP00000275493.2:p.Ser220Phe ENST00000275493.6:c.659C>T 7:g.55152576C>T EGFR ENST00000275493.6 3633 3236 1966340 1966340 1852833 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 23787800 surgery - NOS NS EGFR ENST00000275493.6 3633 3236 1667722 1667722 1581015 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM219791 178385907 c.? p.V845A Substitution - Missense + - Variant of unknown origin 22528563 NS NS ENSP00000275493.2:p.Val845Ala EGFR ENST00000275493.6 3633 3236 2000066 2000066 1884964 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21603 178379091 c.? p.R776H Substitution - Missense + - Variant of unknown origin 23945384 surgery-fixed NS 63 ENSP00000275493.2:p.Arg776His EGFR ENST00000275493.6 3633 3236 1001545 1001545 918768 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20819 178381669 c.? p.K754R Substitution - Missense + - Variant of unknown origin 15851406 surgery-fixed NS ENSP00000275493.2:p.Lys754Arg EGFR ENST00000275493.6 3633 3236 1135552 1135552 1048116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21603 178379091 c.? p.R776H Substitution - Missense + - Variant of unknown origin 18676761 NS NS 65 ENSP00000275493.2:p.Arg776His EGFR ENST00000275493.6 3633 3236 2344981 2344981 2209653 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2156945 2156945 2025920 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24828666 fixed - NOS NS 63 EGFR ENST00000275493.6 3633 3236 2344972 2344972 2209644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1179042 1179042 1091004 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51848529 COSM28929 99439232 c.2168T>C p.F723S Substitution - Missense het 38 7:55174027-55174027 + - PATHOGENIC .97491 Variant of unknown origin 19190079 surgery-fixed primary 54 ENSP00000275493.2:p.Phe723Ser ENST00000275493.6:c.2168T>C 7:g.55174027T>C EGFR ENST00000275493.6 3633 3236 1517073 1517073 1439667 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51835762 COSM88211 99441993 c.2549A>G p.H850R Substitution - Missense het 38 7:55191798-55191798 + - PATHOGENIC .9858 Variant of unknown origin 21592614 surgery-fixed NS 57 ENSP00000275493.2:p.His850Arg ENST00000275493.6:c.2549A>G 7:g.55191798A>G EGFR ENST00000275493.6 3633 3236 2867742 2867742 2722765 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21602 178380317 c.? p.L833V Substitution - Missense + - Variant of unknown origin 25345567 surgery-fixed NS ENSP00000275493.2:p.Leu833Val EGFR ENST00000275493.6 3633 3236 PD36792a 2894864 2749352 skin head_neck NS NS malignant_melanoma NS NS NS y COSV105110843 COSM9876432 99374498 c.3629C>T p.A1210V Substitution - Missense 38 7:55205613-55205613 + - PATHOGENIC .9319 Variant of unknown origin 33024263 surgery-fixed metastasis 72 ENSP00000275493.2:p.Ala1210Val ENST00000275493.6:c.3629C>T 7:g.55205613C>T EGFR ENST00000275493.6 3633 3236 2862688 2862688 2717851 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM9583232 178379810 c.? p.T446K Substitution - Missense + - Variant of unknown origin 31058075 surgery-fixed NS ENSP00000275493.2:p.Thr446Lys EGFR ENST00000275493.6 3633 3236 1638679 1638679 1554678 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 22321542 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2625561 2625561 2485973 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 99380328 c.2612C>G p.A871G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 27056568 surgery-fixed NS 51 ENSP00000275493.2:p.Ala871Gly ENST00000275493.6:c.2612C>G 7:g.55191861C>G EGFR ENST00000275493.6 3633 3236 1098881 1098881 1013473 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773148 COSM26435 99449959 c.2267A>G p.N756S Substitution - Missense 38 7:55174804-55174804 + - PATHOGENIC .9946 Variant of unknown origin 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Asn756Ser ENST00000275493.6:c.2267A>G 7:g.55174804A>G EGFR ENST00000275493.6 3633 3236 1194724 1194724 1106619 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849762 COSM29340 99457539 c.818C>A p.T273N Substitution - Missense 38 7:55154081-55154081 + - PATHOGENIC .90357 Variant of unknown origin 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Thr273Asn ENST00000275493.6:c.818C>A 7:g.55154081C>A EGFR ENST00000275493.6 3633 3236 1996572 1996572 1881781 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1666916 178385282 c.? p.A840T Substitution - Missense + - Variant of unknown origin 23922984 surgery-fixed NS ENSP00000275493.2:p.Ala840Thr EGFR ENST00000275493.6 3633 3236 P-0000030-T01-IM3 2714482 2573303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51789972 COSM6985979 99394178 c.903_906delinsACAC p.T302H Substitution - Missense het 38 7:55155843-55155846 + - Variant of unknown origin 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr302His ENST00000275493.6:c.903_906delinsACAC 7:g.55155843_55155846delinsACAC EGFR ENST00000275493.6 3633 3236 1047968 1047968 964196 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM23623 178382228 c.? p.H773R Substitution - Missense + - Variant of unknown origin 17337084 surgery-fixed NS ENSP00000275493.2:p.His773Arg EGFR ENST00000275493.6 3633 3236 1517065 1517065 1439659 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51785962 COSM88212 99450068 c.2260_2261delinsGC p.K754A Substitution - Missense het 38 7:55174797-55174798 + - Variant of unknown origin 21592614 surgery-fixed NS 45 ENSP00000275493.2:p.Lys754Ala ENST00000275493.6:c.2260_2261delinsGC 7:g.55174797_55174798delinsGC EGFR ENST00000275493.6 3633 3236 LAPC4 2580299 2441636 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51777967 COSM6005629 99426165 c.2939T>A p.V980D Substitution - Missense 38 7:55200406-55200406 + - PATHOGENIC .98972 Variant of unknown origin 20579941 xenograft NS ENSP00000275493.2:p.Val980Asp ENST00000275493.6:c.2939T>A 7:g.55200406T>A EGFR ENST00000275493.6 3633 3236 1729751 1729751 1635722 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21602 178380317 c.? p.L833V Substitution - Missense + - Variant of unknown origin 22805266 NS NS ENSP00000275493.2:p.Leu833Val EGFR ENST00000275493.6 3633 3236 1996919 1996919 1882128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1651578 178380642 c.? p.K714N Substitution - Missense + - Variant of unknown origin 23912954 fixed - NOS NS 41 ENSP00000275493.2:p.Lys714Asn EGFR ENST00000275493.6 3633 3236 2525694 2525694 2387883 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1235366 178384307 c.? p.G724S Substitution - Missense + - Variant of unknown origin 27304188 NS NS ENSP00000275493.2:p.Gly724Ser EGFR ENST00000275493.6 3633 3236 1996918 1996918 1882127 lung NS NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSM1666918 178382702 c.? p.L692F Substitution - Missense + - Variant of unknown origin 23912954 fixed - NOS NS 51 EGFR ENST00000275493.6 3633 3236 1593032 1593032 1513958 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51774247 COSM13008 99380328 c.2612C>G p.A871G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000275493.2:p.Ala871Gly ENST00000275493.6:c.2612C>G 7:g.55191861C>G EGFR ENST00000275493.6 3633 3236 1043132 1043132 959473 upper_aerodigestive_tract tonsil NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51798093 COSM22952 99454963 c.2438A>G p.Y813C Substitution - Missense 38 7:55181447-55181447 + - PATHOGENIC .90224 Variant of unknown origin 17224267 surgery-fixed NS 49 ENSP00000275493.2:p.Tyr813Cys ENST00000275493.6:c.2438A>G 7:g.55181447A>G EGFR ENST00000275493.6 3633 3236 2064702 2064702 1944779 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1651574 178382913 c.? p.V742I Substitution - Missense + - Variant of unknown origin 24251405 surgery-fixed primary ENSP00000275493.2:p.Val742Ile EGFR ENST00000275493.6 3633 3236 TCGA-24-1850-01 1731201 1637167 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51792742 COSM1330578 99455629 c.783G>T p.K261N Substitution - Missense het 38 7:55154046-55154046 + - PATHOGENIC .96256 Variant of unknown origin 331 NS primary 72 ENSP00000275493.2:p.Lys261Asn ENST00000275493.6:c.783G>T 7:g.55154046G>T EGFR ENST00000275493.6 3633 3236 1857881 1857881 1750371 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSM1169666 178380438 c.? p.P596L Substitution - Missense + - Variant of unknown origin 23243055 surgery-fixed NS ENSP00000275493.2:p.Pro596Leu EGFR ENST00000275493.6 3633 3236 1664609 1664609 1578059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 21899495 pleural effusion NS 54 ENSP00000275493.2:p.Glu709Ala EGFR ENST00000275493.6 3633 3236 LC20 2439238 2302079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51781350 COSM5369838 99401899 c.407C>G p.P136R Substitution - Missense 38 7:55143471-55143471 + - PATHOGENIC .90708 Variant of unknown origin 26164066 surgery-fixed metastasis ENSP00000275493.2:p.Pro136Arg ENST00000275493.6:c.407C>G 7:g.55143471C>G EGFR ENST00000275493.6 3633 3236 2083480 2083480 1961763 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM1738011 178383941 c.? p.L862Q Substitution - Missense + - Variant of unknown origin 24481316 surgery - NOS primary 69 ENSP00000275493.2:p.Leu862Gln EGFR ENST00000275493.6 3633 3236 1875149 1875149 1765740 ovary NS NS NS carcinoma serous_carcinoma NS NS n COSM1235288 178382553 c.? p.T751I Substitution - Missense + - Variant of unknown origin 23139256 fixed - NOS NS ENSP00000275493.2:p.Thr751Ile EGFR ENST00000275493.6 3633 3236 1042857 1042857 959198 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51852379 COSM22942 99398784 c.2335G>T p.G779C Substitution - Missense 38 7:55181344-55181344 + - PATHOGENIC .98402 Variant of unknown origin 17285735 surgery - NOS NS ENSP00000275493.2:p.Gly779Cys ENST00000275493.6:c.2335G>T 7:g.55181344G>T EGFR ENST00000275493.6 3633 3236 921173 921173 838132 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM13449 178379663 c.? p.T725M Substitution - Missense het + - Variant of unknown origin 16002952 surgery-fixed primary 57 ENSP00000275493.2:p.Thr725Met EGFR ENST00000275493.6 3633 3236 2202986 2202986 2071244 skin face NS NS carcinoma squamous_cell_carcinoma NS NS n COSM49040 178380912 c.? p.P753S Substitution - Missense + - Variant of unknown origin 24934779 surgery - NOS primary 72 ENSP00000275493.2:p.Pro753Ser EGFR ENST00000275493.6 3633 3236 1594551 1594551 1515519 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51776191 COSM133565 99387374 c.2387G>A p.G796D Substitution - Missense 38 7:55181396-55181396 + - PATHOGENIC .96481 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000275493.2:p.Gly796Asp ENST00000275493.6:c.2387G>A 7:g.55181396G>A EGFR ENST00000275493.6 3633 3236 UCHRP3 2682242 2541515 large_intestine NS NS NS other ulcerative_colitis dysplasia NS n COSV51844380 COSM6854567 99399794 c.856A>G p.S286G Substitution - Missense 38 7:55154119-55154119 + - PATHOGENIC .99273 Variant of unknown origin 28524162 surgery fresh/frozen NS 54 ENSP00000275493.2:p.Ser286Gly ENST00000275493.6:c.856A>G 7:g.55154119A>G EGFR ENST00000275493.6 3633 3236 UCHRP3 2682242 2541515 large_intestine NS NS NS other ulcerative_colitis dysplasia NS n COSV51844399 COSM6854571 99399799 c.1809C>A p.N603K Substitution - Missense 38 7:55165366-55165366 + - PATHOGENIC .87723 Variant of unknown origin 28524162 surgery fresh/frozen NS 54 ENSP00000275493.2:p.Asn603Lys ENST00000275493.6:c.1809C>A 7:g.55165366C>A EGFR ENST00000275493.6 3633 3236 2644141 2644141 2504428 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM4603655 178382423 c.? p.V765M Substitution - Missense + - Variant of unknown origin 28573640 surgery - NOS NS ENSP00000275493.2:p.Val765Met EGFR ENST00000275493.6 3633 3236 2345125 2345125 2209797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 LS411 2301999 2167282 large_intestine colon right NS carcinoma adenocarcinoma NS NS y COSV51794338 COSM3266643 99423710 c.2818A>G p.T940A Substitution - Missense het 38 7:55198833-55198833 + - PATHOGENIC .97948 Variant of unknown origin 24755471 cell-line NS ENSP00000275493.2:p.Thr940Ala ENST00000275493.6:c.2818A>G 7:g.55198833A>G EGFR ENST00000275493.6 3633 3236 1587194 1587194 1508365 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM86999 178381421 c.? p.S784F Substitution - Missense + - Variant of unknown origin 21841502 surgery-fixed NS 55 ENSP00000275493.2:p.Ser784Phe EGFR ENST00000275493.6 3633 3236 2345029 2345029 2209701 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1434741 1434741 1344099 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 20813423 NS primary 59 EGFR ENST00000275493.6 3633 3236 2862232 2862232 2717422 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM1716337 178378584 c.? p.A289V Substitution - Missense + - Variant of unknown origin 25969368 surgery-fixed primary ENSP00000275493.2:p.Ala289Val EGFR ENST00000275493.6 3633 3236 2264417 2264417 2131401 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR ENST00000275493.6 3633 3236 2078489 2078489 1957208 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24378285 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 34 2760142 2618675 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51797913 COSM7339051 99383892 c.2505C>A p.H835Q Substitution - Missense 38 7:55191754-55191754 + - PATHOGENIC .83351 Variant of unknown origin 29876005 surgery-fixed NS ENSP00000275493.2:p.His835Gln ENST00000275493.6:c.2505C>A 7:g.55191754C>A EGFR ENST00000275493.6 3633 3236 2862120 2862120 2717322 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV105110976 COSM9572578 99384878 c.1631G>A p.G544D Substitution - Missense 38 7:55161631-55161631 + - PATHOGENIC .99386 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000275493.2:p.Gly544Asp ENST00000275493.6:c.1631G>A 7:g.55161631G>A EGFR ENST00000275493.6 3633 3236 1517063 1517063 1439657 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51777270 COSM88213 99433673 c.2419G>A p.D807N Substitution - Missense 38 7:55181428-55181428 + - PATHOGENIC .95157 Variant of unknown origin 21592614 surgery-fixed NS 54 ENSP00000275493.2:p.Asp807Asn ENST00000275493.6:c.2419G>A 7:g.55181428G>A EGFR ENST00000275493.6 3633 3236 2732935 2732935 2591688 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51771844 COSM7002278 99386041 c.2941A>C p.I981L Substitution - Missense 38 7:55200408-55200408 + - PATHOGENIC .99358 Variant of unknown origin 28855349 surgery - NOS recurrent 72 ENSP00000275493.2:p.Ile981Leu ENST00000275493.6:c.2941A>C 7:g.55200408A>C EGFR ENST00000275493.6 3633 3236 2026216 2026216 1908305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85907 178384645 c.? p.L788F Substitution - Missense + - Variant of unknown origin 24040454 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1964333 1964333 1850868 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1651577 178380477 c.? p.D837N Substitution - Missense + - Variant of unknown origin 23749122 NS NS ENSP00000275493.2:p.Asp837Asn EGFR ENST00000275493.6 3633 3236 2595744 2595744 2456620 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1235366 178384307 c.? p.G724S Substitution - Missense + - Variant of unknown origin 27538584 surgery-fixed NS 47 ENSP00000275493.2:p.Gly724Ser EGFR ENST00000275493.6 3633 3236 SUPT1 1760532 1665135 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51819830 COSM327147 99388875 c.752G>A p.C251Y Substitution - Missense 38 7:55154015-55154015 + - PATHOGENIC .98182 Variant of unknown origin 22675565 cell-line NS ENSP00000275493.2:p.Cys251Tyr ENST00000275493.6:c.752G>A 7:g.55154015G>A EGFR ENST00000275493.6 3633 3236 TCGA-55-7570-01 1914018 1802300 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51813309 COSM6178064 99448819 c.898G>A p.V300M Substitution - Missense 38 7:55155838-55155838 + - PATHOGENIC .97875 Variant of unknown origin 417 fresh/frozen - NOS primary 60 ENSP00000275493.2:p.Val300Met ENST00000275493.6:c.898G>A 7:g.55155838G>A EGFR ENST00000275493.6 3633 3236 1986227 1986227 1872463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM27111 178379606 c.? p.A871G Substitution - Missense + - Variant of unknown origin 23788756 surgery-fixed NS ENSP00000275493.2:p.Ala871Gly EGFR ENST00000275493.6 3633 3236 BL-18-J14363 2905547 2759803 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864624 COSM10000827 99449231 c.3046T>A p.Y1016N Substitution - Missense 38 7:55201287-55201287 + - PATHOGENIC .99264 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000275493.2:p.Tyr1016Asn ENST00000275493.6:c.3046T>A 7:g.55201287T>A EGFR ENST00000275493.6 3633 3236 2644147 2644147 2504434 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM6493924 178385345 c.? p.Y113H Substitution - Missense + - Variant of unknown origin 28573640 surgery - NOS NS EGFR ENST00000275493.6 3633 3236 2344978 2344978 2209650 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2226201 2226201 2093936 lung NS NS NS carcinoma NS NS NS n COSM4170217 178379057 c.? p.K806R Substitution - Missense + - Variant of unknown origin 24924582 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1047967 1047967 964195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM23623 178382228 c.? p.H773R Substitution - Missense + - Variant of unknown origin 17337084 surgery-fixed NS ENSP00000275493.2:p.His773Arg EGFR ENST00000275493.6 3633 3236 1062887 1062887 978932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM24600 178391495 c.? p.E746I Substitution - Missense + - Variant of unknown origin 17387741 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 CTC3_1 2660939 2521095 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSM6506587 178386077 c.? p.L119S Substitution - Missense + - Variant of unknown origin 27034166 circulating tumour NS EGFR ENST00000275493.6 3633 3236 1479924 1479924 1403584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766584 COSM12371 99382498 c.2126A>T p.E709V Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97538 Variant of unknown origin 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Glu709Val ENST00000275493.6:c.2126A>T 7:g.55173985A>T EGFR ENST00000275493.6 3633 3236 2692870 2692870 2551805 urinary_tract bladder NS NS carcinoma small_cell_carcinoma NS NS n COSM6906042 178381802 c.? p.G663V Substitution - Missense + - Variant of unknown origin 28945843 circulating tumour primary 76 ENSP00000275493.2:p.Gly663Val EGFR ENST00000275493.6 3633 3236 2240649 2240649 2108180 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM29850 178384216 c.? p.A750P Substitution - Missense + - Variant of unknown origin 25179728 NS NS 69 ENSP00000275493.2:p.Ala750Pro EGFR ENST00000275493.6 3633 3236 1047969 1047969 964197 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM23623 178382228 c.? p.H773R Substitution - Missense + - Variant of unknown origin 17337084 surgery-fixed NS ENSP00000275493.2:p.His773Arg EGFR ENST00000275493.6 3633 3236 2264369 2264369 2131353 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR ENST00000275493.6 3633 3236 1194739 1194739 1106634 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51818096 COSM29341 99415690 c.1860C>G p.C620W Substitution - Missense 38 7:55165417-55165417 + - PATHOGENIC .989 Variant of unknown origin 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Cys620Trp ENST00000275493.6:c.1860C>G 7:g.55165417C>G EGFR ENST00000275493.6 3633 3236 2096201 2096201 1974265 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 2732915 2732915 2591668 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827181 COSM7002280 99429261 c.574C>G p.P192A Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .86378 Variant of unknown origin 28855349 surgery - NOS recurrent 58 ENSP00000275493.2:p.Pro192Ala ENST00000275493.6:c.574C>G 7:g.55151308C>G EGFR ENST00000275493.6 3633 3236 H1568 2776237 2634373 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51803615 COSM3266664 99377178 c.3379G>A p.D1127N Substitution - Missense 38 7:55205363-55205363 + - NEUTRAL .13639 Variant of unknown origin 29681454 NS NS 48 ENSP00000275493.2:p.Asp1127Asn ENST00000275493.6:c.3379G>A 7:g.55205363G>A EGFR ENST00000275493.6 3633 3236 2344989 2344989 2209661 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2011183 2011183 1893821 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1684819 178385980 c.? p.N842S Substitution - Missense + - Variant of unknown origin 24002608 surgery - NOS NS EGFR ENST00000275493.6 3633 3236 1587202 1587202 1508373 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM133108 178378894 c.? p.R831L Substitution - Missense + - Variant of unknown origin 21841502 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1162199 1162199 1074531 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51783638 COSM28514 99409705 c.2495G>T p.R832L Substitution - Missense 38 7:55191744-55191744 + - PATHOGENIC .96073 Variant of unknown origin 19020901 NS NS ENSP00000275493.2:p.Arg832Leu ENST00000275493.6:c.2495G>T 7:g.55191744G>T EGFR ENST00000275493.6 3633 3236 1746515 1746515 1651491 endometrium NS NS NS carcinoma NS NS NS n COSM306128 178389082 c.? p.E690K Substitution - Missense + - Variant of unknown origin 22885469 surgery-fixed primary EGFR ENST00000275493.6 3633 3236 2345109 2345109 2209781 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2131913 2131913 2005976 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM97093 178385811 c.? p.P772S Substitution - Missense + - Variant of unknown origin 24376723 fine needle aspirate primary EGFR ENST00000275493.6 3633 3236 2810054 2810054 2666716 stomach NS NS NS carcinoma diffuse_adenocarcinoma NS NS n COSM1651572 178381541 c.? p.A750T Substitution - Missense + - Variant of unknown origin 29307989 stool NS 65 EGFR ENST00000275493.6 3633 3236 2595752 2595752 2456628 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 27538584 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1043127 1043127 959468 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51836619 COSM22950 99384747 c.2351C>A p.S784Y Substitution - Missense 38 7:55181360-55181360 + - PATHOGENIC .95471 Variant of unknown origin 17224267 surgery-fixed NS 61 ENSP00000275493.2:p.Ser784Tyr ENST00000275493.6:c.2351C>A 7:g.55181360C>A EGFR ENST00000275493.6 3633 3236 1284653 1284653 1195948 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM34155 178380594 c.? p.V769M Substitution - Missense + - Variant of unknown origin 16467085 surgery - NOS NS ENSP00000275493.2:p.Val769Met EGFR ENST00000275493.6 3633 3236 2421144 2421144 2284066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25605150 surgery - NOS NS EGFR ENST00000275493.6 3633 3236 1964292 1964292 1850827 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1651575 178390362 c.? p.A743V Substitution - Missense + - Variant of unknown origin 23749122 NS NS ENSP00000275493.2:p.Ala743Val EGFR ENST00000275493.6 3633 3236 24B 2525710 2387898 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM5885108 178388587 c.? p.K754Q Substitution - Missense + - Variant of unknown origin 27304188 surgery-fixed metastasis EGFR ENST00000275493.6 3633 3236 2474560 2474560 2337329 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25882025 surgery - NOS NS 63 EGFR ENST00000275493.6 3633 3236 1594604 1594604 1515572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767322 COSM133630 99430770 c.2573_2574delinsGA p.L858R Substitution - Missense 38 7:55191822-55191823 + - Variant of unknown origin 19724844 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573_2574delinsGA 7:g.55191822_55191823delinsGA EGFR ENST00000275493.6 3633 3236 1881895 1881895 1772046 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM1235366 178384307 c.? p.G724S Substitution - Missense + - Variant of unknown origin 23341890 surgery fresh/frozen primary 40 ENSP00000275493.2:p.Gly724Ser EGFR ENST00000275493.6 3633 3236 2026262 2026262 1908351 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765742 COSM87019 99377391 c.2402A>G p.Y801C Substitution - Missense het 38 7:55181411-55181411 + - PATHOGENIC .95822 Variant of unknown origin 24040454 surgery-fixed NS ENSP00000275493.2:p.Tyr801Cys ENST00000275493.6:c.2402A>G 7:g.55181411A>G EGFR ENST00000275493.6 3633 3236 1162198 1162198 1074530 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51799102 COSM28513 99387223 c.2350T>C p.S784P Substitution - Missense 38 7:55181359-55181359 + - PATHOGENIC .95834 Variant of unknown origin 19020901 NS NS ENSP00000275493.2:p.Ser784Pro ENST00000275493.6:c.2350T>C 7:g.55181359T>C EGFR ENST00000275493.6 3633 3236 1592980 1592980 1513906 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51852524 COSM133204 99387360 c.2498T>G p.L833W Substitution - Missense 38 7:55191747-55191747 + - PATHOGENIC .98181 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu833Trp ENST00000275493.6:c.2498T>G 7:g.55191747T>G EGFR ENST00000275493.6 3633 3236 2675160 2675160 2534434 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51789046 COSM6849766 99406357 c.2210A>G p.K737R Substitution - Missense 38 7:55174747-55174747 + - PATHOGENIC .98813 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000275493.2:p.Lys737Arg ENST00000275493.6:c.2210A>G 7:g.55174747A>G EGFR ENST00000275493.6 3633 3236 1312422 1312422 1223331 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM37043 178391556 c.? p.P733T Substitution - Missense + - Variant of unknown origin 19723643 surgery-fixed NS 60 EGFR ENST00000275493.6 3633 3236 1026464 1026464 943440 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21622 178382929 c.? p.L858A Substitution - Missense + - Variant of unknown origin 17047654 surgery - NOS NS 47 EGFR ENST00000275493.6 3633 3236 2672930 2672930 2532448 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM6848513 178389946 c.? p.V292L Substitution - Missense + - Variant of unknown origin 26191234 surgery-fixed primary ENSP00000275493.2:p.Val292Leu EGFR ENST00000275493.6 3633 3236 1658049 1658049 1572501 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM211764 178383848 c.? p.L703V Substitution - Missense + - Variant of unknown origin 22458769 surgery-fixed primary ENSP00000275493.2:p.Leu703Val EGFR ENST00000275493.6 3633 3236 2842068 2842068 2697617 lung right NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1166938 178380056 c.? p.H773L Substitution - Missense + - Variant of unknown origin 32093862 surgery - NOS metastasis 62 ENSP00000275493.2:p.His773Leu EGFR ENST00000275493.6 3633 3236 1594586 1594586 1515554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51851559 COSM133627 99377966 c.2339T>G p.I780S Substitution - Missense 38 7:55181348-55181348 + - PATHOGENIC .97448 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000275493.2:p.Ile780Ser ENST00000275493.6:c.2339T>G 7:g.55181348T>G EGFR ENST00000275493.6 3633 3236 2344969 2344969 2209641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2113068 2113068 1987329 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51801589 COSM133199 99381946 c.2246A>G p.E749G Substitution - Missense het 38 7:55174783-55174783 + - PATHOGENIC .9946 Variant of unknown origin 24595526 surgery-fixed NS ENSP00000275493.2:p.Glu749Gly ENST00000275493.6:c.2246A>G 7:g.55174783A>G EGFR ENST00000275493.6 3633 3236 2595755 2595755 2456631 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 27538584 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2834143 2834143 2689927 skin mucosal nasopharynx NS malignant_melanoma NS NS NS y COSV104577149 COSM9326313 99443754 c.2252C>A p.T751K Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99307 Variant of unknown origin 28296713 surgery - NOS primary 73 ENSP00000275493.2:p.Thr751Lys ENST00000275493.6:c.2252C>A 7:g.55174789C>A EGFR ENST00000275493.6 3633 3236 2239183 2239183 2106715 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773889 COSM14069 99414148 c.2348C>T p.T783I Substitution - Missense 38 7:55181357-55181357 + - PATHOGENIC .96109 Variant of unknown origin 25130612 surgery - NOS NS 56 ENSP00000275493.2:p.Thr783Ile ENST00000275493.6:c.2348C>T 7:g.55181357C>T EGFR ENST00000275493.6 3633 3236 5-GE005-T1 2869732 2724729 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110870 COSM9656044 99448258 c.2325_2326delinsTT p.R776C Substitution - Missense 38 7:55181334-55181335 + - Variant of unknown origin 26950094 surgery - NOS NS 69 ENSP00000275493.2:p.Arg776Cys ENST00000275493.6:c.2325_2326delinsTT 7:g.55181334_55181335delinsTT EGFR ENST00000275493.6 3633 3236 2029037 2029037 1910919 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1716335 178384702 c.? p.M793I Substitution - Missense het + - Variant of unknown origin 23628817 NS NS ENSP00000275493.2:p.Met793Ile EGFR ENST00000275493.6 3633 3236 2778592 2778592 2636646 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV99286294 COSM7410342 99422570 c.2459A>G p.Q820R Substitution - Missense 38 7:55181468-55181468 + - PATHOGENIC .95287 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000275493.2:p.Gln820Arg ENST00000275493.6:c.2459A>G 7:g.55181468A>G EGFR ENST00000275493.6 3633 3236 2344999 2344999 2209671 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778595 2778595 2636649 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV99294037 COSM7410343 133227583 c.2486G>A p.G829D Substitution - Missense 38 7:55191870-55191870 + - PATHOGENIC .98912 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000415559.1:p.Gly829Asp ENST00000455089.5:c.2486G>A 7:g.55191870G>A EGFR ENST00000275493.6 3633 3236 1162205 1162205 1074537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51829394 COSM28515 99439231 c.2763C>A p.S921R Substitution - Missense 38 7:55198778-55198778 + - .69453 Variant of unknown origin 19020901 NS NS ENSP00000275493.2:p.Ser921Arg ENST00000275493.6:c.2763C>A 7:g.55198778C>A EGFR ENST00000275493.6 3633 3236 1162176 1162176 1074508 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51818033 COSM28508 99400420 c.2104G>T p.A702S Substitution - Missense 38 7:55173963-55173963 + - PATHOGENIC .97325 Variant of unknown origin 19020901 NS NS ENSP00000275493.2:p.Ala702Ser ENST00000275493.6:c.2104G>T 7:g.55173963G>T EGFR ENST00000275493.6 3633 3236 1964332 1964332 1850867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1651577 178380477 c.? p.D837N Substitution - Missense + - Variant of unknown origin 23749122 NS NS ENSP00000275493.2:p.Asp837Asn EGFR ENST00000275493.6 3633 3236 TCGA-08-0349-01 1910225 1798516 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51830791 COSM43068 99456571 c.977G>A p.C326Y Substitution - Missense het 38 7:55155917-55155917 + - PATHOGENIC .99356 Variant of unknown origin 329 fresh/frozen - NOS primary 46 ENSP00000275493.2:p.Cys326Tyr ENST00000275493.6:c.977G>A 7:g.55155917G>A EGFR ENST00000275493.6 3633 3236 2344970 2344970 2209642 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1075803 1075803 991057 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM24863 178384573 c.? p.L858Q Substitution - Missense + - Variant of unknown origin 17575133 fixed - NOS NS ENSP00000275493.2:p.Leu858Gln EGFR ENST00000275493.6 3633 3236 2834143 2834143 2689927 skin mucosal nasopharynx NS malignant_melanoma NS NS NS y COSV104577150 COSM9326314 99443760 c.2969C>T p.P990L Substitution - Missense 38 7:55201210-55201210 + - PATHOGENIC .98952 Variant of unknown origin 28296713 surgery - NOS primary 73 ENSP00000275493.2:p.Pro990Leu ENST00000275493.6:c.2969C>T 7:g.55201210C>T EGFR ENST00000275493.6 3633 3236 2822954 2822954 2678813 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM9167608 178378499 c.? p.L718Q Substitution - Missense + Yes Variant of unknown origin 29807405 surgery - NOS recurrent 53 ENSP00000275493.2:p.Leu718Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862107 2862107 2717309 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV105111081 COSM9572577 133213416 c.1318G>A p.G440S Substitution - Missense 38 7:55160293-55160293 + - NEUTRAL .00282 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000415559.1:p.Gly440Ser ENST00000455089.5:c.1318G>A 7:g.55160293G>A EGFR ENST00000275493.6 3633 3236 2595739 2595739 2456615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 27538584 surgery-fixed NS 69 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2840810 2840810 2696370 prostate NS NS NS carcinoma NS NS NS n COSV104577207 COSM9493802 133285135 c.551G>A p.S184N Substitution - Missense 38 7:55152603-55152603 + - PATHOGENIC .9474 Variant of unknown origin 31874108 surgery-fixed metastasis ENSP00000415559.1:p.Ser184Asn ENST00000455089.5:c.551G>A 7:g.55152603G>A EGFR ENST00000275493.6 3633 3236 HCC461 2776316 2634452 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99034466 COSM7365976 99430488 c.3521A>G p.Q1174R Substitution - Missense 38 7:55205505-55205505 + - PATHOGENIC .94623 Variant of unknown origin 29681454 NS NS 69 ENSP00000275493.2:p.Gln1174Arg ENST00000275493.6:c.3521A>G 7:g.55205505A>G EGFR ENST00000275493.6 3633 3236 2778589 2778589 2636643 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV99296854 COSM7410338 99450595 c.2399A>G p.D800G Substitution - Missense 38 7:55181408-55181408 + - PATHOGENIC .9793 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000275493.2:p.Asp800Gly ENST00000275493.6:c.2399A>G 7:g.55181408A>G EGFR ENST00000275493.6 3633 3236 LUAD_E01166 1765174 1669494 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51795467 COSM390866 99395455 c.709_710delinsTA p.A237Y Substitution - Missense 38 7:55152626-55152627 + - Variant of unknown origin 22980975 surgery - NOS primary ENSP00000275493.2:p.Ala237Tyr ENST00000275493.6:c.709_710delinsTA 7:g.55152626_55152627delinsTA EGFR ENST00000275493.6 3633 3236 1983791 1983791 1870027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 23796143 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2082006 2082006 1960428 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1667028 178390471 c.? p.K757R Substitution - Missense + - Variant of unknown origin 24443522 surgery - NOS NS 31 ENSP00000275493.2:p.Lys757Arg EGFR ENST00000275493.6 3633 3236 WSU-HN13 2296298 2161901 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51826894 COSM4601600 99427367 c.2317C>T p.H773Y Substitution - Missense 38 7:55181326-55181326 + - PATHOGENIC .94421 Variant of unknown origin 25275298 cell-line NS ENSP00000275493.2:p.His773Tyr ENST00000275493.6:c.2317C>T 7:g.55181326C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-D1-A15W-01 1783496 1687495 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51815247 COSM1090893 133204822 c.2615G>C p.G872A Substitution - Missense hom 38 7:55198765-55198765 + - PATHOGENIC .98646 Variant of unknown origin 419 fresh/frozen - NOS primary 58 ENSP00000415559.1:p.Gly872Ala ENST00000455089.5:c.2615G>C 7:g.55198765G>C EGFR ENST00000275493.6 3633 3236 1471809 1471809 1395547 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51780223 COSM28511 99397578 c.2108T>C p.L703P Substitution - Missense 38 7:55173967-55173967 + - PATHOGENIC .90657 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000275493.2:p.Leu703Pro ENST00000275493.6:c.2108T>C 7:g.55173967T>C EGFR ENST00000275493.6 3633 3236 1667721 1667721 1581014 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM27102 178381922 c.? p.R831H Substitution - Missense + - Variant of unknown origin 22528563 NS NS ENSP00000275493.2:p.Arg831His EGFR ENST00000275493.6 3633 3236 5-GE049-T1 2869762 2724759 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110412 COSM9799019 99460366 c.583C>T p.P195S Substitution - Missense 38 7:55151317-55151317 + - NEUTRAL .41768 Variant of unknown origin 26950094 surgery - NOS NS 80 ENSP00000275493.2:p.Pro195Ser ENST00000275493.6:c.583C>T 7:g.55151317C>T EGFR ENST00000275493.6 3633 3236 2867537 2867537 2722577 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 32441866 bronchoalveolar lavage fluid NS 59 ENSP00000275493.2:p.Glu709Ala EGFR ENST00000275493.6 3633 3236 1964337 1964337 1850872 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 23749122 NS NS ENSP00000275493.2:p.Glu709Ala EGFR ENST00000275493.6 3633 3236 2046646 2046646 1926940 lung NS NS NS carcinoma NS NS NS n COSM34155 178380594 c.? p.V769M Substitution - Missense + - Variant of unknown origin 24183104 cytological brushing NS ENSP00000275493.2:p.Val769Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-GE067-T1 2869773 2724770 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51802062 COSM6008937 133213806 c.524C>T p.S175F Substitution - Missense 38 7:55152576-55152576 + - PATHOGENIC .98424 Variant of unknown origin 26950094 surgery - NOS NS ENSP00000415559.1:p.Ser175Phe ENST00000455089.5:c.524C>T 7:g.55152576C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1179042 1179042 1091004 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51848529 COSM28929 133262254 c.2033T>C p.F678S Substitution - Missense het 38 7:55174027-55174027 + - PATHOGENIC .97491 Variant of unknown origin 19190079 surgery-fixed primary 54 ENSP00000415559.1:p.Phe678Ser ENST00000455089.5:c.2033T>C 7:g.55174027T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1517073 1517073 1439667 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51835762 COSM88211 133265220 c.2414A>G p.H805R Substitution - Missense het 38 7:55191798-55191798 + - PATHOGENIC .9858 Variant of unknown origin 21592614 surgery-fixed NS 57 ENSP00000415559.1:p.His805Arg ENST00000455089.5:c.2414A>G 7:g.55191798A>G EGFR ENST00000275493.6 3633 3236 2233641 2233641 2101224 skin NS NS NS malignant_melanoma NS NS NS n COSM4172493 178389216 c.? p.V1047M Substitution - Missense + - Variant of unknown origin 24628946 surgery fresh/frozen NS 87 ENSP00000275493.2:p.Val1047Met EGFR ENST00000275493.6 3633 3236 1696886 1696886 1605014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM249810 178385928 c.? p.P772H Substitution - Missense + - Variant of unknown origin 22674612 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2750886 2750886 2609582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 27086595 surgery-fixed NS 68 EGFR ENST00000275493.6 3633 3236 2750911 2750911 2609607 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM7335290 178386359 c.? p.R803W Substitution - Missense + - Variant of unknown origin 27086595 surgery-fixed NS 66 ENSP00000275493.2:p.Arg803Trp EGFR ENST00000275493.6 3633 3236 1120918 1120918 1034074 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM27103 178383328 c.? p.T847I Substitution - Missense + - Variant of unknown origin 18509184 NS NS ENSP00000275493.2:p.Thr847Ile EGFR ENST00000275493.6 3633 3236 5-GE049-T1 2869762 2724759 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110413 COSM9799052 99460385 c.2995C>T p.R999C Substitution - Missense 38 7:55201236-55201236 + - PATHOGENIC .99346 Variant of unknown origin 26950094 surgery - NOS NS 80 ENSP00000275493.2:p.Arg999Cys ENST00000275493.6:c.2995C>T 7:g.55201236C>T EGFR ENST00000275493.6 3633 3236 2345027 2345027 2209699 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1746513 1746513 1651489 endometrium NS NS NS carcinoma NS NS NS n COSM88795 178382307 c.? p.K754E Substitution - Missense + - Variant of unknown origin 22885469 surgery-fixed primary ENSP00000275493.2:p.Lys754Glu EGFR ENST00000275493.6 3633 3236 2841222 2841222 2696782 prostate NS NS NS carcinoma NS NS NS n COSV104577073 COSM9497234 99452896 c.434A>G p.H145R Substitution - Missense 38 7:55146615-55146615 + - NEUTRAL .16662 Variant of unknown origin 31874108 surgery-fixed primary ENSP00000275493.2:p.His145Arg ENST00000275493.6:c.434A>G 7:g.55146615A>G EGFR ENST00000275493.6 3633 3236 2689645 2689645 2548622 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm peripheral_T_cell_lymphoma_unspecified NS NS n COSV99294651 COSM9178023 99417573 c.2012G>A p.R671H Substitution - Missense 38 7:55173075-55173075 + - PATHOGENIC .98385 Variant of unknown origin 27203213 surgery-fixed NS 75 ENSP00000275493.2:p.Arg671His ENST00000275493.6:c.2012G>A 7:g.55173075G>A EGFR ENST00000275493.6 3633 3236 1881884 1881884 1772035 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1235397 178391256 c.? p.V843L Substitution - Missense + - Variant of unknown origin 23341890 surgery fresh/frozen primary 60 ENSP00000275493.2:p.Val843Leu EGFR ENST00000275493.6 3633 3236 1075799 1075799 991053 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM24861 178385327 c.? p.S720P Substitution - Missense + - Variant of unknown origin 17575133 fixed - NOS NS ENSP00000275493.2:p.Ser720Pro EGFR ENST00000275493.6 3633 3236 1729746 1729746 1635717 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM34155 178380594 c.? p.V769M Substitution - Missense + - Variant of unknown origin 22805266 NS NS ENSP00000275493.2:p.Val769Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625561 2625561 2485973 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 133208531 c.2477C>G p.A826G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 27056568 surgery-fixed NS 51 ENSP00000415559.1:p.Ala826Gly ENST00000455089.5:c.2477C>G 7:g.55191861C>G EGFR ENST00000275493.6 3633 3236 1729739 1729739 1635710 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM255170 178382565 c.? p.E736G Substitution - Missense + - Variant of unknown origin 22805266 NS NS EGFR ENST00000275493.6 3633 3236 1996935 1996935 1882144 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1666924 178385682 c.? p.R836C Substitution - Missense + - Variant of unknown origin 23912954 fixed - NOS NS 55 ENSP00000275493.2:p.Arg836Cys EGFR ENST00000275493.6 3633 3236 2659763 2659763 2519921 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51862250 COSM6506515 99439444 c.2142G>T p.K714N Substitution - Missense 38 7:55174001-55174001 + - PATHOGENIC .88062 Variant of unknown origin 28744312 surgery-fixed NS ENSP00000275493.2:p.Lys714Asn ENST00000275493.6:c.2142G>T 7:g.55174001G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098881 1098881 1013473 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773148 COSM26435 133273088 c.2132A>G p.N711S Substitution - Missense 38 7:55174804-55174804 + - PATHOGENIC .9946 Variant of unknown origin 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Asn711Ser ENST00000455089.5:c.2132A>G 7:g.55174804A>G EGFR ENST00000275493.6 3633 3236 2226199 2226199 2093934 lung NS NS NS carcinoma NS NS NS n COSM4170217 178379057 c.? p.K806R Substitution - Missense + - Variant of unknown origin 24924582 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1837418 1837418 1731617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1166937 178385232 c.? p.R776S Substitution - Missense + - Variant of unknown origin 23242437 NS NS 65 ENSP00000275493.2:p.Arg776Ser EGFR ENST00000275493.6 3633 3236 1879233 1879233 1769788 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51833668 COSM12675 99429874 c.2575G>A p.A859T Substitution - Missense 38 7:55191824-55191824 + - PATHOGENIC .98898 Variant of unknown origin 23468066 surgery-fixed NS 66 ENSP00000275493.2:p.Ala859Thr ENST00000275493.6:c.2575G>A 7:g.55191824G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194724 1194724 1106619 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849762 COSM29340 133281682 c.683C>A p.T228N Substitution - Missense 38 7:55154081-55154081 + - PATHOGENIC .90357 Variant of unknown origin 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Thr228Asn ENST00000455089.5:c.683C>A 7:g.55154081C>A EGFR ENST00000275493.6 3633 3236 2857410 2857410 2712710 skin NS NS NS malignant_melanoma NS NS NS n COSV51767869 COSM3266583 99377861 c.1351C>T p.R451C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 31980996 surgery-fixed NS ENSP00000275493.2:p.Arg451Cys ENST00000275493.6:c.1351C>T 7:g.55160191C>T EGFR ENST00000275493.6 3633 3236 2693332 2693332 2552251 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSM255169 178381173 c.? p.R705K Substitution - Missense + - Variant of unknown origin 28062544 surgery-fixed metastasis EGFR ENST00000275493.6 3633 3236 1120920 1120920 1034076 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM27104 178383972 c.? p.H850D Substitution - Missense + - Variant of unknown origin 18509184 NS NS ENSP00000275493.2:p.His850Asp EGFR ENST00000275493.6 3633 3236 1284676 1284676 1195971 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM34158 178386613 c.? p.T783I Substitution - Missense + - Variant of unknown origin 16467085 surgery - NOS NS ENSP00000275493.2:p.Thr783Ile EGFR ENST00000275493.6 3633 3236 1284676 1284676 1195971 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21603 178379091 c.? p.R776H Substitution - Missense + - Variant of unknown origin 16467085 surgery - NOS NS ENSP00000275493.2:p.Arg776His EGFR ENST00000275493.6 3633 3236 2822055 2822055 2677915 breast NS NS NS carcinoma NS NS NS n COSM9501839 178391429 c.? p.E282K Substitution - Missense + - Variant of unknown origin 26373574 fixed - NOS NS ENSP00000275493.2:p.Glu282Lys EGFR ENST00000275493.6 3633 3236 2644143 2644143 2504430 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1166938 178380056 c.? p.H773L Substitution - Missense + - Variant of unknown origin 28573640 surgery - NOS NS ENSP00000275493.2:p.His773Leu EGFR ENST00000275493.6 3633 3236 2230328 2230328 2098014 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM4172015 178391414 c.? p.R776L Substitution - Missense + - Variant of unknown origin 24781527 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2131912 2131912 2005975 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM3718343 178384830 c.? p.F795S Substitution - Missense + - Variant of unknown origin 24376723 fine needle aspirate primary ENSP00000275493.2:p.Phe795Ser EGFR ENST00000275493.6 3633 3236 2786771 2786771 2644194 autonomic_ganglia sinonasal_and_nasal_cavity NS NS olfactory_neuroblastoma NS NS NS n COSM7448231 178385944 c.? p.Q276R Substitution - Missense + - Variant of unknown origin 29324814 surgery-fixed recurrent 59 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000030-T01-IM3 2714482 2573303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51789972 COSM6985979 133221116 c.768_771delinsACAC p.T257H Substitution - Missense het 38 7:55155843-55155846 + - Variant of unknown origin 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr257His ENST00000455089.5:c.768_771delinsACAC 7:g.55155843_55155846delinsACAC EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LAPC4 2580299 2441636 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51777967 COSM6005629 133250013 c.2804T>A p.V935D Substitution - Missense 38 7:55200406-55200406 + - PATHOGENIC .98972 Variant of unknown origin 20579941 xenograft NS ENSP00000415559.1:p.Val935Asp ENST00000455089.5:c.2804T>A 7:g.55200406T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1517065 1517065 1439659 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51785962 COSM88212 133273211 c.2125_2126delinsGC p.K709A Substitution - Missense het 38 7:55174797-55174798 + - Variant of unknown origin 21592614 surgery-fixed NS 45 ENSP00000415559.1:p.Lys709Ala ENST00000455089.5:c.2125_2126delinsGC 7:g.55174797_55174798delinsGC EGFR ENST00000275493.6 3633 3236 2585246 2585246 2446410 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSM6009001 178378911 c.? p.S464L Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Ser464Leu EGFR ENST00000275493.6 3633 3236 2585246 2585246 2446410 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSM6009000 178378913 c.? p.G465R Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Gly465Arg EGFR ENST00000275493.6 3633 3236 1983789 1983789 1870025 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 23796143 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1881374 1881374 1771525 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1235343 178384301 c.? p.Y275F Substitution - Missense + - Variant of unknown origin 23362162 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 980754 980754 896476 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18058 178384438 c.? p.R803L Substitution - Missense het + - Variant of unknown origin 16564920 surgery-fixed NS 63 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593032 1593032 1513958 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51774247 COSM13008 133208531 c.2477C>G p.A826G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000415559.1:p.Ala826Gly ENST00000455089.5:c.2477C>G 7:g.55191861C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043132 1043132 959473 upper_aerodigestive_tract tonsil NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51798093 COSM22952 133278835 c.2303A>G p.Y768C Substitution - Missense 38 7:55181447-55181447 + - PATHOGENIC .90224 Variant of unknown origin 17224267 surgery-fixed NS 49 ENSP00000415559.1:p.Tyr768Cys ENST00000455089.5:c.2303A>G 7:g.55181447A>G EGFR ENST00000275493.6 3633 3236 2096276 2096276 1974340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 LUAD-F00368 1765250 1669570 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51799133 COSM341496 99442014 c.3300G>T p.R1100S Substitution - Missense 38 7:55205284-55205284 + - PATHOGENIC .767 Variant of unknown origin 22980975 surgery - NOS primary 82 ENSP00000275493.2:p.Arg1100Ser ENST00000275493.6:c.3300G>T 7:g.55205284G>T EGFR ENST00000275493.6 3633 3236 2670401 2670401 2529961 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM6904309 178385063 c.? p.C781F Substitution - Missense + - Variant of unknown origin 28088512 surgery-fixed NS ENSP00000275493.2:p.Cys781Phe EGFR ENST00000275493.6 3633 3236 2345113 2345113 2209785 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-24-1850-01 1731201 1637167 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51792742 COSM1330578 133279641 c.648G>T p.K216N Substitution - Missense het 38 7:55154046-55154046 + - PATHOGENIC .96256 Variant of unknown origin 331 NS primary 72 ENSP00000415559.1:p.Lys216Asn ENST00000455089.5:c.648G>T 7:g.55154046G>T EGFR ENST00000275493.6 3633 3236 1875153 1875153 1765744 soft_tissue fibrous_tissue_and_uncertain_origin NS NS sarcoma spindle NS NS n COSM1235288 178382553 c.? p.T751I Substitution - Missense + - Variant of unknown origin 23139256 fixed - NOS NS ENSP00000275493.2:p.Thr751Ile EGFR ENST00000275493.6 3633 3236 1166435 1166435 1078749 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51813062 COSM12764 99374656 c.2569G>A p.G857R Substitution - Missense het 38 7:55191818-55191818 + - PATHOGENIC .98898 Variant of unknown origin 16870303 surgery - NOS NS 70 ENSP00000275493.2:p.Gly857Arg ENST00000275493.6:c.2569G>A 7:g.55191818G>A EGFR ENST00000275493.6 3633 3236 1451628 1451628 1375771 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51842583 COSM51496 99397045 c.2158T>A p.S720T Substitution - Missense 38 7:55174017-55174017 + - PATHOGENIC .97745 Variant of unknown origin 20855820 surgery - NOS NS ENSP00000275493.2:p.Ser720Thr ENST00000275493.6:c.2158T>A 7:g.55174017T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC20 2439238 2302079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51781350 COSM5369838 133227449 c.407C>G p.P136R Substitution - Missense 38 7:55143471-55143471 + - PATHOGENIC .90708 Variant of unknown origin 26164066 surgery-fixed metastasis ENSP00000415559.1:p.Pro136Arg ENST00000455089.5:c.407C>G 7:g.55143471C>G EGFR ENST00000275493.6 3633 3236 1469948 1469948 1393687 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51844854 COSM53195 99379954 c.2243G>T p.R748I Substitution - Missense 38 7:55174780-55174780 + - PATHOGENIC .99554 Variant of unknown origin 20873989 surgery fresh/frozen primary ENSP00000275493.2:p.Arg748Ile ENST00000275493.6:c.2243G>T 7:g.55174780G>T EGFR ENST00000275493.6 3633 3236 2778591 2778591 2636645 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV99294712 COSM7410341 99392176 c.2455G>A p.V819M Substitution - Missense 38 7:55181464-55181464 + - PATHOGENIC .96467 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000275493.2:p.Val819Met ENST00000275493.6:c.2455G>A 7:g.55181464G>A EGFR ENST00000275493.6 3633 3236 LUAD-NYU408 1765248 1669568 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51855104 COSM374570 99385848 c.1721G>T p.R574L Substitution - Missense 38 7:55163822-55163822 + - PATHOGENIC .93703 Variant of unknown origin 22980975 surgery - NOS primary 71 ENSP00000275493.2:p.Arg574Leu ENST00000275493.6:c.1721G>T 7:g.55163822G>T EGFR ENST00000275493.6 3633 3236 1330081 1330081 1240566 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51809790 COSM41665 99379857 c.2501T>C p.V834A Substitution - Missense 38 7:55191750-55191750 + - PATHOGENIC .97813 Variant of unknown origin 20208477 NS metastasis ENSP00000275493.2:p.Val834Ala ENST00000275493.6:c.2501T>C 7:g.55191750T>C EGFR ENST00000275493.6 3633 3236 2344993 2344993 2209665 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042857 1042857 959198 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51852379 COSM22942 133224094 c.2200G>T p.G734C Substitution - Missense 38 7:55181344-55181344 + - PATHOGENIC .98402 Variant of unknown origin 17285735 surgery - NOS NS ENSP00000415559.1:p.Gly734Cys ENST00000455089.5:c.2200G>T 7:g.55181344G>T EGFR ENST00000275493.6 3633 3236 2096188 2096188 1974252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 2788201 2788201 2645582 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSM7450305 178382232 c.? p.Y891D Substitution - Missense + - Variant of unknown origin 30922578 pleural effusion recurrent 55 EGFR ENST00000275493.6 3633 3236 2163020 2163020 2031604 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1235288 178382553 c.? p.T751I Substitution - Missense + - Variant of unknown origin 24810493 surgery-fixed NS ENSP00000275493.2:p.Thr751Ile EGFR ENST00000275493.6 3633 3236 2096202 2096202 1974266 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594551 1594551 1515519 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51776191 COSM133565 133215541 c.2252G>A p.G751D Substitution - Missense 38 7:55181396-55181396 + - PATHOGENIC .96481 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000415559.1:p.Gly751Asp ENST00000455089.5:c.2252G>A 7:g.55181396G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 UCHRP3 2682242 2541515 large_intestine NS NS NS other ulcerative_colitis dysplasia NS n COSV51844380 COSM6854567 133224974 c.721A>G p.S241G Substitution - Missense 38 7:55154119-55154119 + - PATHOGENIC .99273 Variant of unknown origin 28524162 surgery fresh/frozen NS 54 ENSP00000415559.1:p.Ser241Gly ENST00000455089.5:c.721A>G 7:g.55154119A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 UCHRP3 2682242 2541515 large_intestine NS NS NS other ulcerative_colitis dysplasia NS n COSV51844399 COSM6854571 133224980 c.1674C>A p.N558K Substitution - Missense 38 7:55165366-55165366 + - PATHOGENIC .87723 Variant of unknown origin 28524162 surgery fresh/frozen NS 54 ENSP00000415559.1:p.Asn558Lys ENST00000455089.5:c.1674C>A 7:g.55165366C>A EGFR ENST00000275493.6 3633 3236 1333425 1333425 1243899 salivary_gland parotid NS NS carcinoma salivary_duct_carcinoma NS NS n COSV51840955 COSM41904 99413438 c.2153T>C p.L718P Substitution - Missense 38 7:55174012-55174012 + - PATHOGENIC .95988 Variant of unknown origin 20371674 surgery-fixed NS 57 ENSP00000275493.2:p.Leu718Pro ENST00000275493.6:c.2153T>C 7:g.55174012T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LS411 2301999 2167282 large_intestine colon right NS carcinoma adenocarcinoma NS NS y COSV51794338 COSM3266643 133248088 c.2683A>G p.T895A Substitution - Missense het 38 7:55198833-55198833 + - PATHOGENIC .97948 Variant of unknown origin 24755471 cell-line NS ENSP00000415559.1:p.Thr895Ala ENST00000455089.5:c.2683A>G 7:g.55198833A>G EGFR ENST00000275493.6 3633 3236 2000065 2000065 1884963 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1235366 178384307 c.? p.G724S Substitution - Missense + - Variant of unknown origin 23945384 surgery-fixed NS 45 ENSP00000275493.2:p.Gly724Ser EGFR ENST00000275493.6 3633 3236 KYSE-510 2267703 2134471 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51828940 COSM3266631 99380581 c.2105C>A p.A702D Substitution - Missense 38 7:55173964-55173964 + - PATHOGENIC .97734 Variant of unknown origin 25151357 cell-line NS ENSP00000275493.2:p.Ala702Asp ENST00000275493.6:c.2105C>A 7:g.55173964C>A EGFR ENST00000275493.6 3633 3236 2809833 2809833 2666500 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM9167608 178378499 c.? p.L718Q Substitution - Missense + - Variant of unknown origin 31315676 cerebrospinal fluid recurrent ENSP00000275493.2:p.Leu718Gln EGFR ENST00000275493.6 3633 3236 2345002 2345002 2209674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1966337 1966337 1852830 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 23787800 surgery - NOS NS EGFR ENST00000275493.6 3633 3236 NPC019 2141721 2010939 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 24672248 surgery-fixed NS ENSP00000275493.2:p.Glu709Ala EGFR ENST00000275493.6 3633 3236 GBNEC_1 2907832 2762015 biliary_tract gallbladder NS NS carcinoma small_cell_carcinoma NS NS y COSV105864119 COSM9964764 99410661 c.3139G>A p.V1047M Substitution - Missense 38 7:55201759-55201759 + - NEUTRAL .28639 Variant of unknown origin 33563892 surgery-fixed NS 66 ENSP00000275493.2:p.Val1047Met ENST00000275493.6:c.3139G>A 7:g.55201759G>A EGFR ENST00000275493.6 3633 3236 1567522 1567522 1489154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21602 178380317 c.? p.L833V Substitution - Missense + - Variant of unknown origin 21949883 fine needle aspirate metastasis ENSP00000275493.2:p.Leu833Val EGFR ENST00000275493.6 3633 3236 AC-V16-Tumor-SM-9J46H 2584492 2445656 large_intestine anus NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51811313 COSM6008958 99377481 c.745C>G p.L249V Substitution - Missense 38 7:55152662-55152662 + - PATHOGENIC .95619 Variant of unknown origin 27852700 surgery-fixed recurrent ENSP00000275493.2:p.Leu249Val ENST00000275493.6:c.745C>G 7:g.55152662C>G EGFR ENST00000275493.6 3633 3236 2239186 2239186 2106718 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51787416 COSM219794 99382078 c.2499G>T p.L833F Substitution - Missense 38 7:55191748-55191748 + - PATHOGENIC .95793 Variant of unknown origin 25130612 surgery - NOS NS 76 ENSP00000275493.2:p.Leu833Phe ENST00000275493.6:c.2499G>T 7:g.55191748G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732935 2732935 2591688 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51771844 COSM7002278 133214449 c.2806A>C p.I936L Substitution - Missense 38 7:55200408-55200408 + - PATHOGENIC .99358 Variant of unknown origin 28855349 surgery - NOS recurrent 72 ENSP00000415559.1:p.Ile936Leu ENST00000455089.5:c.2806A>C 7:g.55200408A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862120 2862120 2717322 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV105110976 COSM9572578 133213421 c.1496G>A p.G499D Substitution - Missense 38 7:55161631-55161631 + - PATHOGENIC .99386 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000415559.1:p.Gly499Asp ENST00000455089.5:c.1496G>A 7:g.55161631G>A EGFR ENST00000275493.6 3633 3236 2156946 2156946 2025921 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24828666 fixed - NOS NS 71 EGFR ENST00000275493.6 3633 3236 2896986 2896986 2751324 uterine_adnexa NS NS NS female_adnexal_tumour_of_probable_wolffian_origin NS NS NS n COSV105110843 COSM9876432 99374498 c.3629C>T p.A1210V Substitution - Missense 38 7:55205613-55205613 + - PATHOGENIC .9319 Variant of unknown origin 31591497 NS NS 41 ENSP00000275493.2:p.Ala1210Val ENST00000275493.6:c.3629C>T 7:g.55205613C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1517063 1517063 1439657 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51777270 COSM88213 133257005 c.2284G>A p.D762N Substitution - Missense 38 7:55181428-55181428 + - PATHOGENIC .95157 Variant of unknown origin 21592614 surgery-fixed NS 54 ENSP00000415559.1:p.Asp762Asn ENST00000455089.5:c.2284G>A 7:g.55181428G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 34 2760142 2618675 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51797913 COSM7339051 133212495 c.2370C>A p.H790Q Substitution - Missense 38 7:55191754-55191754 + - PATHOGENIC .83351 Variant of unknown origin 29876005 surgery-fixed NS ENSP00000415559.1:p.His790Gln ENST00000455089.5:c.2370C>A 7:g.55191754C>A EGFR ENST00000275493.6 3633 3236 2000059 2000059 1884957 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 23945384 surgery-fixed NS 54 ENSP00000275493.2:p.Glu709Ala EGFR ENST00000275493.6 3633 3236 1059470 1059470 975540 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM20961 178382552 c.? p.V819A Substitution - Missense + - Variant of unknown origin 17429313 NS NS EGFR ENST00000275493.6 3633 3236 1500142 1500142 1423021 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 21258250 surgery-fixed NS ENSP00000275493.2:p.Glu709Ala EGFR ENST00000275493.6 3633 3236 2898914 2898914 2753185 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS n COSV105863716 COSM9973512 99375485 c.2368A>T p.T790S Substitution - Missense het 38 7:55181377-55181377 + - PATHOGENIC .97936 Variant of unknown origin 27460089 blood-bone marrow NS ENSP00000275493.2:p.Thr790Ser ENST00000275493.6:c.2368A>T 7:g.55181377A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SUPT1 1760532 1665135 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51819830 COSM327147 133216786 c.617G>A p.C206Y Substitution - Missense 38 7:55154015-55154015 + - PATHOGENIC .98182 Variant of unknown origin 22675565 cell-line NS ENSP00000415559.1:p.Cys206Tyr ENST00000455089.5:c.617G>A 7:g.55154015G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-55-7570-01 1914018 1802300 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51813309 COSM6178064 133272077 c.763G>A p.V255M Substitution - Missense 38 7:55155838-55155838 + - PATHOGENIC .97875 Variant of unknown origin 417 fresh/frozen - NOS primary 60 ENSP00000415559.1:p.Val255Met ENST00000455089.5:c.763G>A 7:g.55155838G>A EGFR ENST00000275493.6 3633 3236 2345041 2345041 2209713 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1983788 1983788 1870024 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 23796143 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1120917 1120917 1034073 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM27102 178381922 c.? p.R831H Substitution - Missense + - Variant of unknown origin 18509184 NS NS ENSP00000275493.2:p.Arg831His EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-18-J14363 2905547 2759803 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864624 COSM10000827 133272345 c.2911T>A p.Y971N Substitution - Missense 38 7:55201287-55201287 + - PATHOGENIC .99264 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000415559.1:p.Tyr971Asn ENST00000455089.5:c.2911T>A 7:g.55201287T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479924 1479924 1403584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766584 COSM12371 133211112 c.1991A>T p.E664V Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97538 Variant of unknown origin 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Glu664Val ENST00000455089.5:c.1991A>T 7:g.55173985A>T EGFR ENST00000275493.6 3633 3236 1028970 1028970 945841 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21944 178378514 c.? p.R832H Substitution - Missense + - Variant of unknown origin 17062680 surgery-fixed NS ENSP00000275493.2:p.Arg832His EGFR ENST00000275493.6 3633 3236 2131896 2131896 2005960 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419415 NS NS 72 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194739 1194739 1106634 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51818096 COSM29341 133241432 c.1725C>G p.C575W Substitution - Missense 38 7:55165417-55165417 + - PATHOGENIC .989 Variant of unknown origin 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Cys575Trp ENST00000455089.5:c.1725C>G 7:g.55165417C>G EGFR ENST00000275493.6 3633 3236 PD42092a 2894833 2749321 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV105110933 COSM9881280 99425647 c.1574C>T p.S525F Substitution - Missense 38 7:55161574-55161574 + - PATHOGENIC .96213 Variant of unknown origin 33024263 surgery-fixed metastasis 75 ENSP00000275493.2:p.Ser525Phe ENST00000275493.6:c.1574C>T 7:g.55161574C>T EGFR ENST00000275493.6 3633 3236 2345008 2345008 2209680 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2096280 2096280 1974344 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732915 2732915 2591668 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827181 COSM7002280 133252630 c.439C>G p.P147A Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .86378 Variant of unknown origin 28855349 surgery - NOS recurrent 58 ENSP00000415559.1:p.Pro147Ala ENST00000455089.5:c.439C>G 7:g.55151308C>G EGFR ENST00000275493.6 3633 3236 2757342 2757342 2615979 lung right NS NS carcinoma adenocarcinoma NS NS n COSM30755 178381649 c.? p.K860I Substitution - Missense + - Variant of unknown origin 28274743 surgery - NOS recurrent 41 ENSP00000275493.2:p.Lys860Ile EGFR ENST00000275493.6 3633 3236 2226855 2226855 2094590 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51853800 COSM4170222 99423681 c.2344_2345delinsAA p.L782N Substitution - Missense 38 7:55181353-55181354 + - Variant of unknown origin 24891042 NS NS ENSP00000275493.2:p.Leu782Asn ENST00000275493.6:c.2344_2345delinsAA 7:g.55181353_55181354delinsAA EGFR ENST00000275493.6 3633 3236 1996921 1996921 1882130 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26037 178388590 c.? p.A755D Substitution - Missense + - Variant of unknown origin 23912954 fixed - NOS NS 51 EGFR ENST00000275493.6 3633 3236 1964336 1964336 1850871 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21603 178379091 c.? p.R776H Substitution - Missense + - Variant of unknown origin 23749122 NS NS ENSP00000275493.2:p.Arg776His EGFR ENST00000275493.6 3633 3236 1067068 1067068 983048 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM24669 178390946 c.? p.G719V Substitution - Missense + - Variant of unknown origin 17537621 NS primary EGFR ENST00000275493.6 3633 3236 2345114 2345114 2209786 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 LIM1215_R1_Cetux 2841367 2696923 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576981 COSM9396333 99441637 c.1473A>G p.I491M Substitution - Missense 38 7:55160313-55160313 + - NEUTRAL .12443 Variant of unknown origin 25623215 cell-line NS ENSP00000275493.2:p.Ile491Met ENST00000275493.6:c.1473A>G 7:g.55160313A>G EGFR ENST00000275493.6 3633 3236 2026268 2026268 1908357 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51807481 COSM1716255 99380046 c.2152C>A p.L718M Substitution - Missense 38 7:55174011-55174011 + - PATHOGENIC .91907 Variant of unknown origin 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu718Met ENST00000275493.6:c.2152C>A 7:g.55174011C>A EGFR ENST00000275493.6 3633 3236 1592875 1592875 1513801 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51788476 COSM133180 99392828 c.2086G>A p.G696R Substitution - Missense 38 7:55173945-55173945 + - PATHOGENIC .97714 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000275493.2:p.Gly696Arg ENST00000275493.6:c.2086G>A 7:g.55173945G>A EGFR ENST00000275493.6 3633 3236 MBC032T 2807217 2663921 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99296355 COSM9120806 99447803 c.1655A>C p.N552T Substitution - Missense 38 7:55163756-55163756 + - PATHOGENIC .99524 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000275493.2:p.Asn552Thr ENST00000275493.6:c.1655A>C 7:g.55163756A>C EGFR ENST00000275493.6 3633 3236 1166429 1166429 1078743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773237 COSM28609 99411858 c.2416A>G p.K806E Substitution - Missense hom 38 7:55181425-55181425 + - PATHOGENIC .9712 Variant of unknown origin 16870303 surgery - NOS NS 70 ENSP00000275493.2:p.Lys806Glu ENST00000275493.6:c.2416A>G 7:g.55181425A>G EGFR ENST00000275493.6 3633 3236 1166429 1166429 1078743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773222 COSM28608 99411852 c.2393T>A p.L798H Substitution - Missense het 38 7:55181402-55181402 + - PATHOGENIC .95568 Variant of unknown origin 16870303 surgery - NOS NS 70 ENSP00000275493.2:p.Leu798His ENST00000275493.6:c.2393T>A 7:g.55181402T>A EGFR ENST00000275493.6 3633 3236 1166429 1166429 1078743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773249 COSM28610 99411864 c.2441T>C p.L814P Substitution - Missense hom 38 7:55181450-55181450 + - PATHOGENIC .94523 Variant of unknown origin 16870303 surgery - NOS NS 70 ENSP00000275493.2:p.Leu814Pro ENST00000275493.6:c.2441T>C 7:g.55181450T>C EGFR ENST00000275493.6 3633 3236 2584876 2584876 2446040 large_intestine colon right NS carcinoma adenocarcinoma NS NS n COSM6009001 178378911 c.? p.S464L Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Ser464Leu EGFR ENST00000275493.6 3633 3236 2584876 2584876 2446040 large_intestine colon right NS carcinoma adenocarcinoma NS NS n COSM6009002 178389370 c.? p.I491M Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Ile491Met EGFR ENST00000275493.6 3633 3236 1996922 1996922 1882131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1666922 178390203 c.? p.K737T Substitution - Missense + - Variant of unknown origin 23912954 fixed - NOS NS 55 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162199 1162199 1074531 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51783638 COSM28514 133236788 c.2360G>T p.R787L Substitution - Missense 38 7:55191744-55191744 + - PATHOGENIC .96073 Variant of unknown origin 19020901 NS NS ENSP00000415559.1:p.Arg787Leu ENST00000455089.5:c.2360G>T 7:g.55191744G>T EGFR ENST00000275493.6 3633 3236 MYL-007 2672891 2532410 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS n COSM6848490 178386961 c.? p.C620W Substitution - Missense + - Variant of unknown origin 28492226 circulating tumour NS ENSP00000275493.2:p.Cys620Trp EGFR ENST00000275493.6 3633 3236 MBC069T 2807244 2663948 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99296428 COSM9120810 99450603 c.2069A>T p.E690V Substitution - Missense 38 7:55173928-55173928 + - PATHOGENIC .98747 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000275493.2:p.Glu690Val ENST00000275493.6:c.2069A>T 7:g.55173928A>T EGFR ENST00000275493.6 3633 3236 1135551 1135551 1048115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21603 178379091 c.? p.R776H Substitution - Missense + - Variant of unknown origin 18676761 NS NS 52 ENSP00000275493.2:p.Arg776His EGFR ENST00000275493.6 3633 3236 1479923 1479923 1403583 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM25842 178385658 c.? p.V689L Substitution - Missense + - Variant of unknown origin 21151896 surgery fresh/frozen primary EGFR ENST00000275493.6 3633 3236 2481860 2481860 2344605 pleura NS NS NS mesothelioma epithelial NS NS n COSM5656407 178385277 c.? p.P243A Substitution - Missense + - Variant of unknown origin 26463840 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1471796 1471796 1395534 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51770794 COSM53213 99393113 c.2604A>T p.E868D Substitution - Missense 38 7:55191853-55191853 + - PATHOGENIC .79152 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000275493.2:p.Glu868Asp ENST00000275493.6:c.2604A>T 7:g.55191853A>T EGFR ENST00000275493.6 3633 3236 CTC6 2660942 2521095 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSM6506616 178381112 c.? p.P281T Substitution - Missense + - Variant of unknown origin 27034166 circulating tumour NS EGFR ENST00000275493.6 3633 3236 2131917 2131917 2005980 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM3718345 178382933 c.? p.V845M Substitution - Missense + - Variant of unknown origin 24376723 surgery-fixed metastasis ENSP00000275493.2:p.Val845Met EGFR ENST00000275493.6 3633 3236 1857890 1857890 1750380 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1169670 178385768 c.? p.V651M Substitution - Missense + - Variant of unknown origin 23243055 surgery-fixed secondary ENSP00000275493.2:p.Val651Met EGFR ENST00000275493.6 3633 3236 2345042 2345042 2209714 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1746514 1746514 1651490 endometrium NS NS NS carcinoma NS NS NS n COSM306127 178381916 c.? p.L688F Substitution - Missense + - Variant of unknown origin 22885469 surgery-fixed primary EGFR ENST00000275493.6 3633 3236 1484391 1484391 1408017 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSM85899 178385561 c.? p.G796V Substitution - Missense + - Variant of unknown origin 21266046 surgery-fixed primary 64 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043127 1043127 959468 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51836619 COSM22950 133213289 c.2216C>A p.S739Y Substitution - Missense 38 7:55181360-55181360 + - PATHOGENIC .95471 Variant of unknown origin 17224267 surgery-fixed NS 61 ENSP00000415559.1:p.Ser739Tyr ENST00000455089.5:c.2216C>A 7:g.55181360C>A EGFR ENST00000275493.6 3633 3236 1715964 1715964 1623526 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM28619 178383742 c.? p.V786M Substitution - Missense + - Variant of unknown origin 22760226 surgery - NOS NS 62 ENSP00000275493.2:p.Val786Met EGFR ENST00000275493.6 3633 3236 1592877 1592877 1513803 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51807024 COSM41905 99389634 c.2092G>A p.A698T Substitution - Missense 38 7:55173951-55173951 + - PATHOGENIC .96084 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000275493.2:p.Ala698Thr ENST00000275493.6:c.2092G>A 7:g.55173951G>A EGFR ENST00000275493.6 3633 3236 2264416 2264416 2131400 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR ENST00000275493.6 3633 3236 2908040 2908040 2762219 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM10045248 178382394 c.? p.L833_V834delinsFL Substitution - Missense + - Variant of unknown origin 24457237 surgery-fixed NS 62 ENSP00000275493.2:p.Leu833_Val834delinsPheLeu EGFR ENST00000275493.6 3633 3236 1592889 1592889 1513815 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51789815 COSM133185 99393153 c.2186G>A p.G729E Substitution - Missense 38 7:55174723-55174723 + - PATHOGENIC .99879 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000275493.2:p.Gly729Glu ENST00000275493.6:c.2186G>A 7:g.55174723G>A EGFR ENST00000275493.6 3633 3236 2579691 2579691 2441028 NS NS NS NS malignant_melanoma NS NS NS n COSV51786271 COSM6005743 99439428 c.2108T>A p.L703H Substitution - Missense 38 7:55173967-55173967 + - PATHOGENIC .8277 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000275493.2:p.Leu703His ENST00000275493.6:c.2108T>A 7:g.55173967T>A EGFR ENST00000275493.6 3633 3236 1668670 1668670 1581962 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 22523351 fixed - NOS NS ENSP00000275493.2:p.Glu709Ala EGFR ENST00000275493.6 3633 3236 2228274 2228274 2096005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25103305 blood-bone marrow NS EGFR ENST00000275493.6 3633 3236 2759185 2759185 2617735 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour borderline NS n COSM1716337 178378584 c.? p.A289V Substitution - Missense + - Variant of unknown origin 27566247 surgery-fixed NS ENSP00000275493.2:p.Ala289Val EGFR ENST00000275493.6 3633 3236 2626134 2626134 2486546 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51791433 COSM6191492 99446162 c.887_888delinsTT p.P296L Substitution - Missense 38 7:55154150-55154151 + - Variant of unknown origin 26645239 surgery-fixed NS ENSP00000275493.2:p.Pro296Leu ENST00000275493.6:c.887_888delinsTT 7:g.55154150_55154151delinsTT EGFR ENST00000275493.6 3633 3236 2908023 2908023 2762206 lung right_middle_lobe NS NS carcinoma small_cell_carcinoma NS NS n COSM10045264 178380239 c.? p.E872K Substitution - Missense + - Variant of unknown origin 24457237 surgery-fixed metastasis 60 ENSP00000275493.2:p.Glu872Lys EGFR ENST00000275493.6 3633 3236 AA3-14 2539113 2400702 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSM5945735 178383705 c.? p.G449V Substitution - Missense + - Variant of unknown origin 25257301 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1471797 1471797 1395535 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51849843 COSM53265 99457558 c.2556G>T p.K852N Substitution - Missense 38 7:55191805-55191805 + - PATHOGENIC .94296 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000275493.2:p.Lys852Asn ENST00000275493.6:c.2556G>T 7:g.55191805G>T EGFR ENST00000275493.6 3633 3236 2264420 2264420 2131404 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR ENST00000275493.6 3633 3236 2345018 2345018 2209690 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2672943 2672943 2532451 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM6848514 178383386 c.? p.A702V Substitution - Missense + - Variant of unknown origin 26191234 surgery-fixed primary ENSP00000275493.2:p.Ala702Val EGFR ENST00000275493.6 3633 3236 2345024 2345024 2209696 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1964295 1964295 1850830 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1651576 178384420 c.? p.S768_V769delinsIL Substitution - Missense + - Variant of unknown origin 23749122 NS NS ENSP00000275493.2:p.Ser768_Val769delinsIleLeu EGFR ENST00000275493.6 3633 3236 2131909 2131909 2005972 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM3718340 178388992 c.? p.D807G Substitution - Missense + - Variant of unknown origin 24376723 fine needle aspirate primary EGFR ENST00000275493.6 3633 3236 2081826 2081826 1960248 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24481317 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2898402 2898402 2752680 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21602 178380317 c.? p.L833V Substitution - Missense + - Variant of unknown origin 23800712 fixed - NOS NS ENSP00000275493.2:p.Leu833Val EGFR ENST00000275493.6 3633 3236 1881381 1881381 1771532 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1235343 178384301 c.? p.Y275F Substitution - Missense + - Variant of unknown origin 23362162 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1881381 1881381 1771532 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1235341 178387389 c.? p.H773P Substitution - Missense + - Variant of unknown origin 23362162 surgery-fixed NS ENSP00000275493.2:p.His773Pro EGFR ENST00000275493.6 3633 3236 1875150 1875150 1765741 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS n COSM27536 178380580 c.? p.H773Y Substitution - Missense + - Variant of unknown origin 23139256 fixed - NOS NS ENSP00000275493.2:p.His773Tyr EGFR ENST00000275493.6 3633 3236 2046608 2046608 1926902 lung NS NS NS carcinoma NS NS NS n COSM13449 178379663 c.? p.T725M Substitution - Missense + - Variant of unknown origin 24183104 cytological brushing NS ENSP00000275493.2:p.Thr725Met EGFR ENST00000275493.6 3633 3236 1587208 1587208 1508379 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM133108 178378894 c.? p.R831L Substitution - Missense + - Variant of unknown origin 21841502 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2841036 2841036 2696596 prostate NS NS NS carcinoma NS NS NS n COSV104576574 COSM9495067 99458905 c.3602C>A p.A1201E Substitution - Missense 38 7:55205586-55205586 + - PATHOGENIC .80096 Variant of unknown origin 31874108 surgery-fixed primary ENSP00000275493.2:p.Ala1201Glu ENST00000275493.6:c.3602C>A 7:g.55205586C>A EGFR ENST00000275493.6 3633 3236 2841036 2841036 2696596 prostate NS NS NS carcinoma NS NS NS n COSV104576576 COSM9495068 99458909 c.3604C>A p.P1202T Substitution - Missense 38 7:55205588-55205588 + - NEUTRAL .47889 Variant of unknown origin 31874108 surgery-fixed primary ENSP00000275493.2:p.Pro1202Thr ENST00000275493.6:c.3604C>A 7:g.55205588C>A EGFR ENST00000275493.6 3633 3236 2841036 2841036 2696596 prostate NS NS NS carcinoma NS NS NS n COSV104576573 COSM9493957 99458900 c.3593_3594delinsGC p.L1198R Substitution - Missense 38 7:55205577-55205578 + - Variant of unknown origin 31874108 surgery-fixed primary ENSP00000275493.2:p.Leu1198Arg ENST00000275493.6:c.3593_3594delinsGC 7:g.55205577_55205578delinsGC EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594604 1594604 1515572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767322 COSM133630 133254168 c.2438_2439delinsGA p.L813R Substitution - Missense 38 7:55191822-55191823 + - Variant of unknown origin 19724844 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438_2439delinsGA 7:g.55191822_55191823delinsGA EGFR ENST00000275493.6 3633 3236 2226770 2226770 2094505 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51789815 COSM133185 99393153 c.2186G>A p.G729E Substitution - Missense 38 7:55174723-55174723 + - PATHOGENIC .99879 Variant of unknown origin 24891042 NS NS ENSP00000275493.2:p.Gly729Glu ENST00000275493.6:c.2186G>A 7:g.55174723G>A EGFR ENST00000275493.6 3633 3236 VOA1947 2897843 2752142 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105864361 COSM9970409 99436203 c.970C>T p.R324C Substitution - Missense 38 7:55155910-55155910 + - PATHOGENIC .91299 Variant of unknown origin 31477716 surgery-fixed metastasis 69 ENSP00000275493.2:p.Arg324Cys ENST00000275493.6:c.970C>T 7:g.55155910C>T EGFR ENST00000275493.6 3633 3236 1230487 1230487 1142301 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM27536 178380580 c.? p.H773Y Substitution - Missense + - Variant of unknown origin 19536777 NS NS ENSP00000275493.2:p.His773Tyr EGFR ENST00000275493.6 3633 3236 2157025 2157025 2026000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24828666 fixed - NOS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592980 1592980 1513906 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51852524 COSM133204 133215533 c.2363T>G p.L788W Substitution - Missense 38 7:55191747-55191747 + - PATHOGENIC .98181 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu788Trp ENST00000455089.5:c.2363T>G 7:g.55191747T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675160 2675160 2534434 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51789046 COSM6849766 133232661 c.2075A>G p.K692R Substitution - Missense 38 7:55174747-55174747 + - PATHOGENIC .98813 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000415559.1:p.Lys692Arg ENST00000455089.5:c.2075A>G 7:g.55174747A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2026262 2026262 1908351 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765742 COSM87019 133205370 c.2267A>G p.Y756C Substitution - Missense het 38 7:55181411-55181411 + - PATHOGENIC .95822 Variant of unknown origin 24040454 surgery-fixed NS ENSP00000415559.1:p.Tyr756Cys ENST00000455089.5:c.2267A>G 7:g.55181411A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162198 1162198 1074530 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51799102 COSM28513 133215426 c.2215T>C p.S739P Substitution - Missense 38 7:55181359-55181359 + - PATHOGENIC .95834 Variant of unknown origin 19020901 NS NS ENSP00000415559.1:p.Ser739Pro ENST00000455089.5:c.2215T>C 7:g.55181359T>C EGFR ENST00000275493.6 3633 3236 1029015 1029015 945886 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM22543 178382202 c.? p.A743S Substitution - Missense + - Variant of unknown origin 17075123 NS NS EGFR ENST00000275493.6 3633 3236 PGBM22 1630920 1547790 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51799872 COSM53266 99426449 c.2165C>T p.A722V Substitution - Missense 38 7:55174024-55174024 + - PATHOGENIC .97625 Variant of unknown origin 22286061 surgery - NOS NS ENSP00000275493.2:p.Ala722Val ENST00000275493.6:c.2165C>T 7:g.55174024C>T EGFR ENST00000275493.6 3633 3236 914803 914803 832252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51806784 COSM12428 99398840 c.2125_2127delinsCAT p.E709H Substitution - Missense 38 7:55173984-55173986 + - Variant of unknown origin 15738541 surgery fresh/frozen recurrent ENSP00000275493.2:p.Glu709His ENST00000275493.6:c.2125_2127delinsCAT 7:g.55173984_55173986delinsCAT EGFR ENST00000275493.6 3633 3236 1052732 1052732 968803 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51798115 COSM24268 99382217 c.2572_2573delinsAA p.L858K Substitution - Missense 38 7:55191821-55191822 + - Variant of unknown origin 17368623 NS NS ENSP00000275493.2:p.Leu858Lys ENST00000275493.6:c.2572_2573delinsAA 7:g.55191821_55191822delinsAA EGFR ENST00000275493.6 3633 3236 1246736 1246736 1158415 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 19692680 surgery - NOS NS EGFR ENST00000275493.6 3633 3236 2241832 2241832 2109363 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25228365 NS primary EGFR ENST00000275493.6 3633 3236 2096200 2096200 1974264 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 2346551 2346551 2211214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM4778281 178384168 c.? p.L861K Substitution - Missense + - Variant of unknown origin 25687872 surgery-fixed NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594586 1594586 1515554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51851559 COSM133627 133206052 c.2204T>G p.I735S Substitution - Missense 38 7:55181348-55181348 + - PATHOGENIC .97448 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000415559.1:p.Ile735Ser ENST00000455089.5:c.2204T>G 7:g.55181348T>G EGFR ENST00000275493.6 3633 3236 TCGA-02-0116-01 1910165 1798456 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51795519 COSM35822 99457227 c.1789G>C p.A597P Substitution - Missense hom 38 7:55165346-55165346 + - NEUTRAL .2004 Variant of unknown origin 329 fresh/frozen - NOS primary 54 ENSP00000275493.2:p.Ala597Pro ENST00000275493.6:c.1789G>C 7:g.55165346G>C EGFR ENST00000275493.6 3633 3236 2345120 2345120 2209792 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1567517 1567517 1489149 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM34155 178380594 c.? p.V769M Substitution - Missense + - Variant of unknown origin 21949883 fine needle aspirate metastasis ENSP00000275493.2:p.Val769Met EGFR ENST00000275493.6 3633 3236 TCGA-B0-5116-01 1779843 1683842 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51823166 COSM485465 99387247 c.3125G>A p.S1042N Substitution - Missense hom 38 7:55201745-55201745 + - PATHOGENIC .98326 Variant of unknown origin 416 fresh/frozen - NOS primary 52 ENSP00000275493.2:p.Ser1042Asn ENST00000275493.6:c.3125G>A 7:g.55201745G>A EGFR ENST00000275493.6 3633 3236 1459448 1459448 1383391 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 20637128 surgery-fixed primary EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2113068 2113068 1987329 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51801589 COSM133199 133210332 c.2111A>G p.E704G Substitution - Missense het 38 7:55174783-55174783 + - PATHOGENIC .9946 Variant of unknown origin 24595526 surgery-fixed NS ENSP00000415559.1:p.Glu704Gly ENST00000455089.5:c.2111A>G 7:g.55174783A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-GE005-T1 2869732 2724729 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110870 COSM9656044 133271736 c.2190_2191delinsTT p.R731C Substitution - Missense 38 7:55181334-55181335 + - Variant of unknown origin 26950094 surgery - NOS NS 69 ENSP00000415559.1:p.Arg731Cys ENST00000455089.5:c.2190_2191delinsTT 7:g.55181334_55181335delinsTT EGFR ENST00000275493.6 3633 3236 2064730 2064730 1944807 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1717881 178380716 c.? p.D830N Substitution - Missense + - Variant of unknown origin 24251405 surgery-fixed primary EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239183 2239183 2106715 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773889 COSM14069 133240281 c.2213C>T p.T738I Substitution - Missense 38 7:55181357-55181357 + - PATHOGENIC .96109 Variant of unknown origin 25130612 surgery - NOS NS 56 ENSP00000415559.1:p.Thr738Ile ENST00000455089.5:c.2213C>T 7:g.55181357C>T EGFR ENST00000275493.6 3633 3236 1026456 1026456 943432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21621 178387289 c.? p.F856L Substitution - Missense + - Variant of unknown origin 17047654 surgery - NOS NS 63 ENSP00000275493.2:p.Phe856Leu EGFR ENST00000275493.6 3633 3236 2026146 2026146 1908235 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51807481 COSM1716255 99380046 c.2152C>A p.L718M Substitution - Missense 38 7:55174011-55174011 + - PATHOGENIC .91907 Variant of unknown origin 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu718Met ENST00000275493.6:c.2152C>A 7:g.55174011C>A EGFR ENST00000275493.6 3633 3236 2644139 2644139 2504426 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1651578 178380642 c.? p.K714N Substitution - Missense + - Variant of unknown origin 28573640 surgery - NOS NS ENSP00000275493.2:p.Lys714Asn EGFR ENST00000275493.6 3633 3236 2757343 2757343 2615980 lung right NS NS carcinoma adenocarcinoma NS NS n COSM30755 178381649 c.? p.K860I Substitution - Missense + - Variant of unknown origin 28274743 surgery - NOS metastasis 41 ENSP00000275493.2:p.Lys860Ile EGFR ENST00000275493.6 3633 3236 2096193 2096193 1974257 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2834143 2834143 2689927 skin mucosal nasopharynx NS malignant_melanoma NS NS NS y COSV104577150 COSM9326314 133267092 c.2834C>T p.P945L Substitution - Missense 38 7:55201210-55201210 + - PATHOGENIC .98952 Variant of unknown origin 28296713 surgery - NOS primary 73 ENSP00000415559.1:p.Pro945Leu ENST00000455089.5:c.2834C>T 7:g.55201210C>T EGFR ENST00000275493.6 3633 3236 1043126 1043126 959467 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51776999 COSM22949 99410106 c.2585T>C p.L862P Substitution - Missense 38 7:55191834-55191834 + - PATHOGENIC .97782 Variant of unknown origin 17224267 surgery-fixed NS 23 ENSP00000275493.2:p.Leu862Pro ENST00000275493.6:c.2585T>C 7:g.55191834T>C EGFR ENST00000275493.6 3633 3236 1330080 1330080 1240565 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51809790 COSM41665 99379857 c.2501T>C p.V834A Substitution - Missense het 38 7:55191750-55191750 + - PATHOGENIC .97813 Variant of unknown origin 20208477 surgery - NOS NS ENSP00000275493.2:p.Val834Ala ENST00000275493.6:c.2501T>C 7:g.55191750T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778592 2778592 2636646 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV99286294 COSM7410342 133247063 c.2324A>G p.Q775R Substitution - Missense 38 7:55181468-55181468 + - PATHOGENIC .95287 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000415559.1:p.Gln775Arg ENST00000455089.5:c.2324A>G 7:g.55181468A>G EGFR ENST00000275493.6 3633 3236 2728558 2728558 2587369 cervix NS NS NS carcinoma mesonephric_carcinoma NS NS n COSV51846371 COSM7338932 99430450 c.2918G>A p.R973Q Substitution - Missense 38 7:55200385-55200385 + - PATHOGENIC .99379 Variant of unknown origin 26336887 surgery-fixed primary 51 ENSP00000275493.2:p.Arg973Gln ENST00000275493.6:c.2918G>A 7:g.55200385G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162176 1162176 1074508 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51818033 COSM28508 133225609 c.1969G>T p.A657S Substitution - Missense 38 7:55173963-55173963 + - PATHOGENIC .97325 Variant of unknown origin 19020901 NS NS ENSP00000415559.1:p.Ala657Ser ENST00000455089.5:c.1969G>T 7:g.55173963G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162205 1162205 1074537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51829394 COSM28515 133262248 c.2628C>A p.S876R Substitution - Missense 38 7:55198778-55198778 + - .69453 Variant of unknown origin 19020901 NS NS ENSP00000415559.1:p.Ser876Arg ENST00000455089.5:c.2628C>A 7:g.55198778C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-08-0349-01 1910225 1798516 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51830791 COSM43068 133280683 c.842G>A p.C281Y Substitution - Missense het 38 7:55155917-55155917 + - PATHOGENIC .99356 Variant of unknown origin 329 fresh/frozen - NOS primary 46 ENSP00000415559.1:p.Cys281Tyr ENST00000455089.5:c.842G>A 7:g.55155917G>A EGFR ENST00000275493.6 3633 3236 1005423 1005423 922635 lung right NS NS carcinoma adenocarcinoma NS NS n COSM20894 178379162 c.? p.A859T Substitution - Missense + - Variant of unknown origin 16775247 surgery - NOS primary 60 ENSP00000275493.2:p.Ala859Thr EGFR ENST00000275493.6 3633 3236 2585240 2585240 2446404 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSM6009006 178378912 c.? p.G465E Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Gly465Glu EGFR ENST00000275493.6 3633 3236 2585240 2585240 2446404 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSM6009000 178378913 c.? p.G465R Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Gly465Arg EGFR ENST00000275493.6 3633 3236 1612908 1612908 1532136 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21602 178380317 c.? p.L833V Substitution - Missense + - Variant of unknown origin 18083107 surgery - NOS NS ENSP00000275493.2:p.Leu833Val EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2834143 2834143 2689927 skin mucosal nasopharynx NS malignant_melanoma NS NS NS y COSV104577149 COSM9326313 133267087 c.2117C>A p.T706K Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99307 Variant of unknown origin 28296713 surgery - NOS primary 73 ENSP00000415559.1:p.Thr706Lys ENST00000455089.5:c.2117C>A 7:g.55174789C>A EGFR ENST00000275493.6 3633 3236 1594589 1594589 1515557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51776191 COSM133565 99387374 c.2387G>A p.G796D Substitution - Missense 38 7:55181396-55181396 + - PATHOGENIC .96481 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000275493.2:p.Gly796Asp ENST00000275493.6:c.2387G>A 7:g.55181396G>A EGFR ENST00000275493.6 3633 3236 2786772 2786772 2644195 autonomic_ganglia sinonasal_and_nasal_cavity NS NS olfactory_neuroblastoma NS NS NS n COSM7448232 178385932 c.? p.T572R Substitution - Missense + - Variant of unknown origin 29324814 surgery-fixed recurrent 57 EGFR ENST00000275493.6 3633 3236 1484294 1484294 1407920 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51771443 COSM12727 99378003 c.2551G>A p.V851I Substitution - Missense 38 7:55191800-55191800 + - PATHOGENIC .98898 Variant of unknown origin 21266046 surgery-fixed primary 67 ENSP00000275493.2:p.Val851Ile ENST00000275493.6:c.2551G>A 7:g.55191800G>A EGFR ENST00000275493.6 3633 3236 2585248 2585248 2446412 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSM6009001 178378911 c.? p.S464L Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Ser464Leu EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778589 2778589 2636643 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV99296854 COSM7410338 133273833 c.2264A>G p.D755G Substitution - Missense 38 7:55181408-55181408 + - PATHOGENIC .9793 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000415559.1:p.Asp755Gly ENST00000455089.5:c.2264A>G 7:g.55181408A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 WSU-HN13 2296298 2161901 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51826894 COSM4601600 133250811 c.2182C>T p.H728Y Substitution - Missense 38 7:55181326-55181326 + - PATHOGENIC .94421 Variant of unknown origin 25275298 cell-line NS ENSP00000415559.1:p.His728Tyr ENST00000455089.5:c.2182C>T 7:g.55181326C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD_E01166 1765174 1669494 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51795467 COSM390866 133221875 c.574_575delinsTA p.A192Y Substitution - Missense 38 7:55152626-55152627 + - Variant of unknown origin 22980975 surgery - NOS primary ENSP00000415559.1:p.Ala192Tyr ENST00000455089.5:c.574_575delinsTA 7:g.55152626_55152627delinsTA EGFR ENST00000275493.6 3633 3236 1024772 1024772 941749 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21602 178380317 c.? p.L833V Substitution - Missense + - Variant of unknown origin 17020982 NS primary ENSP00000275493.2:p.Leu833Val EGFR ENST00000275493.6 3633 3236 1741422 1741422 1647024 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM303916 178388269 c.? p.P733L Substitution - Missense + - Variant of unknown origin 22870241 surgery-fixed primary ENSP00000275493.2:p.Pro733Leu EGFR ENST00000275493.6 3633 3236 1695695 1695695 1603907 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM249788 178379530 c.? p.L858V Substitution - Missense + - Variant of unknown origin 22673630 surgery - NOS NS 68 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471809 1471809 1395547 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51780223 COSM28511 133223277 c.1973T>C p.L658P Substitution - Missense 38 7:55173967-55173967 + - PATHOGENIC .90657 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000415559.1:p.Leu658Pro ENST00000455089.5:c.1973T>C 7:g.55173967T>C EGFR ENST00000275493.6 3633 3236 1484365 1484365 1407991 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSM85907 178384645 c.? p.L788F Substitution - Missense + - Variant of unknown origin 21266046 surgery-fixed primary 66 EGFR ENST00000275493.6 3633 3236 2345123 2345123 2209795 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2113069 2113069 1987330 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51788551 COSM214349 99392841 c.2071C>T p.P691S Substitution - Missense het 38 7:55173930-55173930 + - PATHOGENIC .98279 Variant of unknown origin 24595526 surgery-fixed NS ENSP00000275493.2:p.Pro691Ser ENST00000275493.6:c.2071C>T 7:g.55173930C>T EGFR ENST00000275493.6 3633 3236 1471802 1471802 1395540 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51780223 COSM28511 99397578 c.2108T>C p.L703P Substitution - Missense 38 7:55173967-55173967 + - PATHOGENIC .90657 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000275493.2:p.Leu703Pro ENST00000275493.6:c.2108T>C 7:g.55173967T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-GE049-T1 2869762 2724759 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110412 COSM9799019 133285068 c.448C>T p.P150S Substitution - Missense 38 7:55151317-55151317 + - NEUTRAL .41768 Variant of unknown origin 26950094 surgery - NOS NS 80 ENSP00000415559.1:p.Pro150Ser ENST00000455089.5:c.448C>T 7:g.55151317C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-GE049-T1 2869762 2724759 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110413 COSM9799052 133285095 c.2860C>T p.R954C Substitution - Missense 38 7:55201236-55201236 + - PATHOGENIC .99346 Variant of unknown origin 26950094 surgery - NOS NS 80 ENSP00000415559.1:p.Arg954Cys ENST00000455089.5:c.2860C>T 7:g.55201236C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2689645 2689645 2548622 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm peripheral_T_cell_lymphoma_unspecified NS NS n COSV99294651 COSM9178023 133242917 c.1877G>A p.R626H Substitution - Missense 38 7:55173075-55173075 + - PATHOGENIC .98385 Variant of unknown origin 27203213 surgery-fixed NS 75 ENSP00000415559.1:p.Arg626His ENST00000455089.5:c.1877G>A 7:g.55173075G>A EGFR ENST00000275493.6 3633 3236 1047964 1047964 964192 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM23618 178380108 c.? p.S811F Substitution - Missense + - Variant of unknown origin 17337084 surgery-fixed NS ENSP00000275493.2:p.Ser811Phe EGFR ENST00000275493.6 3633 3236 2131916 2131916 2005979 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1666917 178385443 c.? p.K708N Substitution - Missense + - Variant of unknown origin 24376723 surgery-fixed metastasis EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659763 2659763 2519921 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51862250 COSM6506515 133262505 c.2007G>T p.K669N Substitution - Missense 38 7:55174001-55174001 + - PATHOGENIC .88062 Variant of unknown origin 28744312 surgery-fixed NS ENSP00000415559.1:p.Lys669Asn ENST00000455089.5:c.2007G>T 7:g.55174001G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879233 1879233 1769788 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51833668 COSM12675 133253212 c.2440G>A p.A814T Substitution - Missense 38 7:55191824-55191824 + - PATHOGENIC .98898 Variant of unknown origin 23468066 surgery-fixed NS 66 ENSP00000415559.1:p.Ala814Thr ENST00000455089.5:c.2440G>A 7:g.55191824G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2857410 2857410 2712710 skin NS NS NS malignant_melanoma NS NS NS n COSV51767869 COSM3266583 133205938 c.1216C>T p.R406C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 31980996 surgery-fixed NS ENSP00000415559.1:p.Arg406Cys ENST00000455089.5:c.1216C>T 7:g.55160191C>T EGFR ENST00000275493.6 3633 3236 1996916 1996916 1882125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM24862 178381344 c.? p.I706T Substitution - Missense + - Variant of unknown origin 23912954 fixed - NOS NS 54 EGFR ENST00000275493.6 3633 3236 2046609 2046609 1926903 lung NS NS NS carcinoma NS NS NS n COSM23618 178380108 c.? p.S811F Substitution - Missense + - Variant of unknown origin 24183104 cytological brushing NS ENSP00000275493.2:p.Ser811Phe EGFR ENST00000275493.6 3633 3236 1668677 1668677 1581969 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM53308 178382874 c.? p.L858P Substitution - Missense + - Variant of unknown origin 22523351 fixed - NOS NS EGFR ENST00000275493.6 3633 3236 LPS31 2800466 2657282 soft_tissue fat upper_leg NS liposarcoma myxoid-round_cell NS NS n COSV99286196 COSM9110952 99402911 c.3464C>A p.A1155D Substitution - Missense 38 7:55205448-55205448 + - NEUTRAL .17478 Variant of unknown origin 26643872 surgery - NOS primary 45 ENSP00000275493.2:p.Ala1155Asp ENST00000275493.6:c.3464C>A 7:g.55205448C>A EGFR ENST00000275493.6 3633 3236 1098817 1098817 1013409 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 99380328 c.2612C>G p.A871G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 18176089 surgery fresh/frozen primary 51 ENSP00000275493.2:p.Ala871Gly ENST00000275493.6:c.2612C>G 7:g.55191861C>G EGFR ENST00000275493.6 3633 3236 2344983 2344983 2209655 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2228275 2228275 2096005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25103305 blood-bone marrow NS EGFR ENST00000275493.6 3633 3236 1656008 1656008 1570665 peritoneum NS NS NS mesothelioma NS NS NS n COSV51844929 COSM211635 99441551 c.2548C>T p.H850Y Substitution - Missense het 38 7:55191797-55191797 + - PATHOGENIC .97885 Variant of unknown origin 22426987 surgery-fixed NS 58 ENSP00000275493.2:p.His850Tyr ENST00000275493.6:c.2548C>T 7:g.55191797C>T EGFR ENST00000275493.6 3633 3236 1097610 1097610 1012271 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26411 178380422 c.? p.S720F Substitution - Missense + - Variant of unknown origin 18172267 surgery-fixed NS ENSP00000275493.2:p.Ser720Phe EGFR ENST00000275493.6 3633 3236 1638678 1638678 1554677 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 22321542 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2026149 2026149 1908238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51785295 COSM1716257 99429920 c.2326C>A p.R776S Substitution - Missense het 38 7:55181335-55181335 + - PATHOGENIC .9754 Variant of unknown origin 24040454 surgery-fixed NS ENSP00000275493.2:p.Arg776Ser ENST00000275493.6:c.2326C>A 7:g.55181335C>A EGFR ENST00000275493.6 3633 3236 1875154 1875154 1765745 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSM1235289 178384783 c.? p.P741S Substitution - Missense + - Variant of unknown origin 23139256 fixed - NOS NS ENSP00000275493.2:p.Pro741Ser EGFR ENST00000275493.6 3633 3236 2163021 2163021 2031605 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM3736930 178389016 c.? p.T751A Substitution - Missense + - Variant of unknown origin 24810493 surgery-fixed NS ENSP00000275493.2:p.Thr751Ala EGFR ENST00000275493.6 3633 3236 911620 911620 829103 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51771443 COSM12727 99378003 c.2551G>A p.V851I Substitution - Missense 38 7:55191800-55191800 + - PATHOGENIC .98898 Variant of unknown origin 15870435 surgery-fixed primary ENSP00000275493.2:p.Val851Ile ENST00000275493.6:c.2551G>A 7:g.55191800G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1469948 1469948 1393687 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51844854 COSM53195 133208147 c.2108G>T p.R703I Substitution - Missense 38 7:55174780-55174780 + - PATHOGENIC .99554 Variant of unknown origin 20873989 surgery fresh/frozen primary ENSP00000415559.1:p.Arg703Ile ENST00000455089.5:c.2108G>T 7:g.55174780G>T EGFR ENST00000275493.6 3633 3236 2264371 2264371 2131355 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR ENST00000275493.6 3633 3236 1802256 1802256 1703975 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 23136191 surgery-fixed NS 76 EGFR ENST00000275493.6 3633 3236 1667719 1667719 1581012 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM26412 178384237 c.? p.G779S Substitution - Missense + - Variant of unknown origin 22528563 NS NS ENSP00000275493.2:p.Gly779Ser EGFR ENST00000275493.6 3633 3236 1592876 1592876 1513802 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51825508 COSM133181 99387192 c.2087G>A p.G696E Substitution - Missense 38 7:55173946-55173946 + - PATHOGENIC .98116 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000275493.2:p.Gly696Glu ENST00000275493.6:c.2087G>A 7:g.55173946G>A EGFR ENST00000275493.6 3633 3236 1074944 1074944 990198 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51811855 COSM24848 99416024 c.2581C>G p.L861V Substitution - Missense 38 7:55191830-55191830 + - PATHOGENIC .93198 Variant of unknown origin 17573511 fine needle aspirate metastasis 67 ENSP00000275493.2:p.Leu861Val ENST00000275493.6:c.2581C>G 7:g.55191830C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166435 1166435 1078749 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51813062 COSM12764 133203122 c.2434G>A p.G812R Substitution - Missense het 38 7:55191818-55191818 + - PATHOGENIC .98898 Variant of unknown origin 16870303 surgery - NOS NS 70 ENSP00000415559.1:p.Gly812Arg ENST00000455089.5:c.2434G>A 7:g.55191818G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1451628 1451628 1375771 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51842583 COSM51496 133222942 c.2023T>A p.S675T Substitution - Missense 38 7:55174017-55174017 + - PATHOGENIC .97745 Variant of unknown origin 20855820 surgery - NOS NS ENSP00000415559.1:p.Ser675Thr ENST00000455089.5:c.2023T>A 7:g.55174017T>A EGFR ENST00000275493.6 3633 3236 TCGA-08-0246-01 1910219 1798510 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51792876 COSM43066 99380179 c.767A>C p.D256A Substitution - Missense hom 38 7:55154030-55154030 + - PATHOGENIC .98125 Variant of unknown origin 329 fresh/frozen - NOS primary 57 ENSP00000275493.2:p.Asp256Ala ENST00000275493.6:c.767A>C 7:g.55154030A>C EGFR ENST00000275493.6 3633 3236 TCGA-78-7147-01 1914054 1802336 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51797369 COSM6178060 99433323 c.1159C>A p.L387M Substitution - Missense 38 7:55156784-55156784 + - PATHOGENIC .85999 Variant of unknown origin 417 fresh/frozen - NOS primary 67 ENSP00000275493.2:p.Leu387Met ENST00000275493.6:c.1159C>A 7:g.55156784C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-NYU408 1765248 1669568 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51855104 COSM374570 133214283 c.1586G>T p.R529L Substitution - Missense 38 7:55163822-55163822 + - PATHOGENIC .93703 Variant of unknown origin 22980975 surgery - NOS primary 71 ENSP00000415559.1:p.Arg529Leu ENST00000455089.5:c.1586G>T 7:g.55163822G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1330081 1330081 1240566 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51809790 COSM41665 133208046 c.2366T>C p.V789A Substitution - Missense 38 7:55191750-55191750 + - PATHOGENIC .97813 Variant of unknown origin 20208477 NS metastasis ENSP00000415559.1:p.Val789Ala ENST00000455089.5:c.2366T>C 7:g.55191750T>C EGFR ENST00000275493.6 3633 3236 2841043 2841043 2696603 prostate NS NS NS carcinoma NS NS NS n COSV104576883 COSM9496261 99408536 c.3568T>C p.S1190P Substitution - Missense 38 7:55205552-55205552 + - NEUTRAL .06347 Variant of unknown origin 31874108 surgery-fixed primary ENSP00000275493.2:p.Ser1190Pro ENST00000275493.6:c.3568T>C 7:g.55205552T>C EGFR ENST00000275493.6 3633 3236 NAN8 2809783 2666453 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV99289308 COSM9153923 99404513 c.2053G>C p.E685Q Substitution - Missense het 38 7:55173116-55173116 + - PATHOGENIC .99493 Variant of unknown origin 30545397 cell-line primary ENSP00000275493.2:p.Glu685Gln ENST00000275493.6:c.2053G>C 7:g.55173116G>C EGFR ENST00000275493.6 3633 3236 2344997 2344997 2209669 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778591 2778591 2636645 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV99294712 COSM7410341 133219716 c.2320G>A p.V774M Substitution - Missense 38 7:55181464-55181464 + - PATHOGENIC .96467 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000415559.1:p.Val774Met ENST00000455089.5:c.2320G>A 7:g.55181464G>A EGFR ENST00000275493.6 3633 3236 2861867 2861867 2717077 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM9571903 178388133 c.? p.K80T Substitution - Missense + - Variant of unknown origin 31548343 circulating tumour NS EGFR ENST00000275493.6 3633 3236 2011182 2011182 1893820 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1684818 178384529 c.? p.N826D Substitution - Missense + - Variant of unknown origin 24002608 surgery - NOS NS EGFR ENST00000275493.6 3633 3236 2156948 2156948 2025923 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24828666 fixed - NOS NS 71 EGFR ENST00000275493.6 3633 3236 AMO1 2809758 2666428 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasmacytoma NS NS y COSV51777457 COSM1236015 99402374 c.627A>C p.K209N Substitution - Missense het 38 7:55151361-55151361 + - NEUTRAL .14933 Variant of unknown origin 30545397 cell-line NS ENSP00000275493.2:p.Lys209Asn ENST00000275493.6:c.627A>C 7:g.55151361A>C EGFR ENST00000275493.6 3633 3236 2131891 2131891 2005955 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419415 NS NS 63 EGFR ENST00000275493.6 3633 3236 2047821 2047821 1928093 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24197981 surgery-fixed metastasis EGFR ENST00000275493.6 3633 3236 2595756 2595756 2456632 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 27538584 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2344982 2344982 2209654 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2345026 2345026 2209698 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2011148 2011148 1893786 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM34157 178387563 c.? p.E866K Substitution - Missense + - Variant of unknown origin 24002608 surgery - NOS NS ENSP00000275493.2:p.Glu866Lys EGFR ENST00000275493.6 3633 3236 NAN8 2809783 2666453 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV99289304 COSM9153919 99404496 c.670C>T p.R224C Substitution - Missense het 38 7:55152587-55152587 + - PATHOGENIC .90413 Variant of unknown origin 30545397 cell-line primary ENSP00000275493.2:p.Arg224Cys ENST00000275493.6:c.670C>T 7:g.55152587C>T EGFR ENST00000275493.6 3633 3236 MBC531 2807310 2664014 breast NS NS NS carcinoma NS NS NS n COSV99286738 COSM9120811 99457582 c.1219A>G p.I407V Substitution - Missense 38 7:55157674-55157674 + - PATHOGENIC .99284 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000275493.2:p.Ile407Val ENST00000275493.6:c.1219A>G 7:g.55157674A>G EGFR ENST00000275493.6 3633 3236 2113075 2113075 1987336 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51772282 COSM133202 99384247 c.2336G>A p.G779D Substitution - Missense het 38 7:55181345-55181345 + - PATHOGENIC .98244 Variant of unknown origin 24595526 surgery-fixed NS ENSP00000275493.2:p.Gly779Asp ENST00000275493.6:c.2336G>A 7:g.55181345G>A EGFR ENST00000275493.6 3633 3236 1523089 1523089 1445461 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51813062 COSM12764 99374656 c.2569G>A p.G857R Substitution - Missense het 38 7:55191818-55191818 + - PATHOGENIC .98898 Variant of unknown origin 21284055 surgery-fixed NS ENSP00000275493.2:p.Gly857Arg ENST00000275493.6:c.2569G>A 7:g.55191818G>A EGFR ENST00000275493.6 3633 3236 1333424 1333424 1243898 salivary_gland parotid NS NS carcinoma salivary_duct_carcinoma NS NS n COSV51807685 COSM13177 99392776 c.2063T>C p.L688P Substitution - Missense 38 7:55173922-55173922 + - PATHOGENIC .97819 Variant of unknown origin 20371674 surgery-fixed NS 61 ENSP00000275493.2:p.Leu688Pro ENST00000275493.6:c.2063T>C 7:g.55173922T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1333425 1333425 1243899 salivary_gland parotid NS NS carcinoma salivary_duct_carcinoma NS NS n COSV51840955 COSM41904 133239708 c.2018T>C p.L673P Substitution - Missense 38 7:55174012-55174012 + - PATHOGENIC .95988 Variant of unknown origin 20371674 surgery-fixed NS 57 ENSP00000415559.1:p.Leu673Pro ENST00000455089.5:c.2018T>C 7:g.55174012T>C EGFR ENST00000275493.6 3633 3236 2841043 2841043 2696603 prostate NS NS NS carcinoma NS NS NS n COSV104576881 COSM9496259 99408527 c.3541G>A p.A1181T Substitution - Missense 38 7:55205525-55205525 + - .62231 Variant of unknown origin 31874108 surgery-fixed primary ENSP00000275493.2:p.Ala1181Thr ENST00000275493.6:c.3541G>A 7:g.55205525G>A EGFR ENST00000275493.6 3633 3236 2692867 2692867 2551804 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSM4603655 178382423 c.? p.V765M Substitution - Missense + - Variant of unknown origin 28945843 surgery-fixed primary 76 ENSP00000275493.2:p.Val765Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KYSE-510 2267703 2134471 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51828940 COSM3266631 133208784 c.1970C>A p.A657D Substitution - Missense 38 7:55173964-55173964 + - PATHOGENIC .97734 Variant of unknown origin 25151357 cell-line NS ENSP00000415559.1:p.Ala657Asp ENST00000455089.5:c.1970C>A 7:g.55173964C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBNEC_1 2907832 2762015 biliary_tract gallbladder NS NS carcinoma small_cell_carcinoma NS NS y COSV105864119 COSM9964764 133237602 c.3004G>A p.V1002M Substitution - Missense 38 7:55201759-55201759 + - NEUTRAL .28639 Variant of unknown origin 33563892 surgery-fixed NS 66 ENSP00000415559.1:p.Val1002Met ENST00000455089.5:c.3004G>A 7:g.55201759G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 AC-V16-Tumor-SM-9J46H 2584492 2445656 large_intestine anus NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51811313 COSM6008958 133205540 c.610C>G p.L204V Substitution - Missense 38 7:55152662-55152662 + - PATHOGENIC .95619 Variant of unknown origin 27852700 surgery-fixed recurrent ENSP00000415559.1:p.Leu204Val ENST00000455089.5:c.610C>G 7:g.55152662C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239186 2239186 2106718 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51787416 COSM219794 133210501 c.2364G>T p.L788F Substitution - Missense 38 7:55191748-55191748 + - PATHOGENIC .95793 Variant of unknown origin 25130612 surgery - NOS NS 76 ENSP00000415559.1:p.Leu788Phe ENST00000455089.5:c.2364G>T 7:g.55191748G>T EGFR ENST00000275493.6 3633 3236 1964290 1964290 1850825 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1235289 178384783 c.? p.P741S Substitution - Missense + - Variant of unknown origin 23749122 NS NS ENSP00000275493.2:p.Pro741Ser EGFR ENST00000275493.6 3633 3236 1036635 1036635 953392 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM22422 178380883 c.? p.S768C Substitution - Missense + - Variant of unknown origin 17201173 NS NS EGFR ENST00000275493.6 3633 3236 2 2557184 2418609 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51828150 COSM5976431 99379210 c.1555G>A p.E519K Substitution - Missense 38 7:55161555-55161555 + - PATHOGENIC .8557 Variant of unknown origin 26934577 surgery fresh/frozen NS ENSP00000275493.2:p.Glu519Lys ENST00000275493.6:c.1555G>A 7:g.55161555G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2898914 2898914 2753185 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS n COSV105863716 COSM9973512 133203786 c.2233A>T p.T745S Substitution - Missense het 38 7:55181377-55181377 + - PATHOGENIC .97936 Variant of unknown origin 27460089 blood-bone marrow NS ENSP00000415559.1:p.Thr745Ser ENST00000455089.5:c.2233A>T 7:g.55181377A>T EGFR ENST00000275493.6 3633 3236 1551569 1551569 1473674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM30755 178381649 c.? p.K860I Substitution - Missense + - Variant of unknown origin 21858063 surgery-fixed NS ENSP00000275493.2:p.Lys860Ile EGFR ENST00000275493.6 3633 3236 1042854 1042854 959195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766584 COSM12371 99382498 c.2126A>T p.E709V Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97538 Variant of unknown origin 17285735 surgery - NOS NS ENSP00000275493.2:p.Glu709Val ENST00000275493.6:c.2126A>T 7:g.55173985A>T EGFR ENST00000275493.6 3633 3236 1966260 1966260 1852753 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM27103 178383328 c.? p.T847I Substitution - Missense + - Variant of unknown origin 23800712 fixed - NOS NS ENSP00000275493.2:p.Thr847Ile EGFR ENST00000275493.6 3633 3236 1083336 1083336 998501 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM26033 178382648 c.? p.H805I Substitution - Missense + - Variant of unknown origin 17596643 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1535059 1535059 1457394 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM27111 178379606 c.? p.A871G Substitution - Missense + - Variant of unknown origin 21720997 surgery - NOS NS ENSP00000275493.2:p.Ala871Gly EGFR ENST00000275493.6 3633 3236 OV207 1716842 1624327 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51806026 COSM252488 99415733 c.493C>T p.R165W Substitution - Missense 38 7:55146674-55146674 + - NEUTRAL .14815 Variant of unknown origin 22102435 surgery fresh/frozen NS ENSP00000275493.2:p.Arg165Trp ENST00000275493.6:c.493C>T 7:g.55146674C>T EGFR ENST00000275493.6 3633 3236 2585234 2585234 2446398 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSM6009001 178378911 c.? p.S464L Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Ser464Leu EGFR ENST00000275493.6 3633 3236 2585234 2585234 2446398 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSM6009006 178378912 c.? p.G465E Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Gly465Glu EGFR ENST00000275493.6 3633 3236 2585234 2585234 2446398 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSM6009000 178378913 c.? p.G465R Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Gly465Arg EGFR ENST00000275493.6 3633 3236 2485527 2485527 2348226 NS NS NS NS malignant_melanoma NS NS NS n COSV51794536 COSM5702630 99375515 c.3407C>T p.P1136L Substitution - Missense 38 7:55205391-55205391 + - PATHOGENIC .96718 Variant of unknown origin 25886620 fixed - NOS NS ENSP00000275493.2:p.Pro1136Leu ENST00000275493.6:c.3407C>T 7:g.55205391C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD42092a 2894833 2749321 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV105110933 COSM9881280 133249665 c.1439C>T p.S480F Substitution - Missense 38 7:55161574-55161574 + - PATHOGENIC .96213 Variant of unknown origin 33024263 surgery-fixed metastasis 75 ENSP00000415559.1:p.Ser480Phe ENST00000455089.5:c.1439C>T 7:g.55161574C>T EGFR ENST00000275493.6 3633 3236 2667843 2667843 2527505 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1716337 178378584 c.? p.A289V Substitution - Missense + - Variant of unknown origin 28663030 surgery-fixed recurrent ENSP00000275493.2:p.Ala289Val EGFR ENST00000275493.6 3633 3236 HEC-6 2030473 1912263 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSM1716337 178378584 c.? p.A289V Substitution - Missense + - Variant of unknown origin 23674493 cell-line NS ENSP00000275493.2:p.Ala289Val EGFR ENST00000275493.6 3633 3236 2667828 2667828 2527490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1716337 178378584 c.? p.A289V Substitution - Missense + - Variant of unknown origin 28663030 surgery-fixed primary ENSP00000275493.2:p.Ala289Val EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226855 2226855 2094590 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51853800 COSM4170222 133248065 c.2209_2210delinsAA p.L737N Substitution - Missense 38 7:55181353-55181354 + - Variant of unknown origin 24891042 NS NS ENSP00000415559.1:p.Leu737Asn ENST00000455089.5:c.2209_2210delinsAA 7:g.55181353_55181354delinsAA EGFR ENST00000275493.6 3633 3236 2011075 2011075 1893713 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1684816 178383812 c.? p.G724D Substitution - Missense + - Variant of unknown origin 24002608 surgery - NOS NS EGFR ENST00000275493.6 3633 3236 1964288 1964288 1850823 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1651572 178381541 c.? p.A750T Substitution - Missense + - Variant of unknown origin 23749122 NS NS EGFR ENST00000275493.6 3633 3236 7199 2897738 2752037 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105864119 COSM9964764 99410661 c.3139G>A p.V1047M Substitution - Missense 38 7:55201759-55201759 + - NEUTRAL .28639 Variant of unknown origin 31477716 surgery-fixed metastasis 51 ENSP00000275493.2:p.Val1047Met ENST00000275493.6:c.3139G>A 7:g.55201759G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592875 1592875 1513801 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51788476 COSM133180 133220155 c.1951G>A p.G651R Substitution - Missense 38 7:55173945-55173945 + - PATHOGENIC .97714 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000415559.1:p.Gly651Arg ENST00000455089.5:c.1951G>A 7:g.55173945G>A EGFR ENST00000275493.6 3633 3236 1213633 1213633 1125500 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM29850 178384216 c.? p.A750P Substitution - Missense + - Variant of unknown origin 18978556 surgery - NOS NS ENSP00000275493.2:p.Ala750Pro EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LIM1215_R1_Cetux 2841367 2696923 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576981 COSM9396333 133264813 c.1338A>G p.I446M Substitution - Missense 38 7:55160313-55160313 + - NEUTRAL .12443 Variant of unknown origin 25623215 cell-line NS ENSP00000415559.1:p.Ile446Met ENST00000455089.5:c.1338A>G 7:g.55160313A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2026268 2026268 1908357 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51807481 COSM1716255 133208224 c.2017C>A p.L673M Substitution - Missense 38 7:55174011-55174011 + - PATHOGENIC .91907 Variant of unknown origin 24040454 surgery-fixed NS ENSP00000415559.1:p.Leu673Met ENST00000455089.5:c.2017C>A 7:g.55174011C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MBC032T 2807217 2663921 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99296355 COSM9120806 133271237 c.1520A>C p.N507T Substitution - Missense 38 7:55163756-55163756 + - PATHOGENIC .99524 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000415559.1:p.Asn507Thr ENST00000455089.5:c.1520A>C 7:g.55163756A>C EGFR ENST00000275493.6 3633 3236 5347 915985 833384 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51867018 COSM13191 99455077 c.2392C>T p.L798F Substitution - Missense 38 7:55181401-55181401 + - PATHOGENIC .94619 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000275493.2:p.Leu798Phe ENST00000275493.6:c.2392C>T 7:g.55181401C>T EGFR ENST00000275493.6 3633 3236 2238944 2238944 2106476 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM27111 178379606 c.? p.A871G Substitution - Missense + - Variant of unknown origin 25137181 blood-bone marrow NS ENSP00000275493.2:p.Ala871Gly EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166429 1166429 1078743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773237 COSM28609 133238380 c.2281A>G p.K761E Substitution - Missense hom 38 7:55181425-55181425 + - PATHOGENIC .9712 Variant of unknown origin 16870303 surgery - NOS NS 70 ENSP00000415559.1:p.Lys761Glu ENST00000455089.5:c.2281A>G 7:g.55181425A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166429 1166429 1078743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773249 COSM28610 133238386 c.2306T>C p.L769P Substitution - Missense hom 38 7:55181450-55181450 + - PATHOGENIC .94523 Variant of unknown origin 16870303 surgery - NOS NS 70 ENSP00000415559.1:p.Leu769Pro ENST00000455089.5:c.2306T>C 7:g.55181450T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166429 1166429 1078743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773222 COSM28608 133238376 c.2258T>A p.L753H Substitution - Missense het 38 7:55181402-55181402 + - PATHOGENIC .95568 Variant of unknown origin 16870303 surgery - NOS NS 70 ENSP00000415559.1:p.Leu753His ENST00000455089.5:c.2258T>A 7:g.55181402T>A EGFR ENST00000275493.6 3633 3236 1097655 1097655 1012316 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26413 178382100 c.? p.V851I Substitution - Missense + - Variant of unknown origin 18172267 surgery-fixed NS ENSP00000275493.2:p.Val851Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MBC069T 2807244 2663948 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99296428 COSM9120810 133273838 c.1934A>T p.E645V Substitution - Missense 38 7:55173928-55173928 + - PATHOGENIC .98747 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000415559.1:p.Glu645Val ENST00000455089.5:c.1934A>T 7:g.55173928A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471796 1471796 1395534 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51770794 COSM53213 133220434 c.2469A>T p.E823D Substitution - Missense 38 7:55191853-55191853 + - PATHOGENIC .79152 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000415559.1:p.Glu823Asp ENST00000455089.5:c.2469A>T 7:g.55191853A>T EGFR ENST00000275493.6 3633 3236 2345110 2345110 2209782 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1593034 1593034 1513960 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51770642 COSM22992 99380893 c.2161G>A p.G721S Substitution - Missense 38 7:55174020-55174020 + - PATHOGENIC .98289 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000275493.2:p.Gly721Ser ENST00000275493.6:c.2161G>A 7:g.55174020G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592877 1592877 1513803 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51807024 COSM41905 133217449 c.1957G>A p.A653T Substitution - Missense 38 7:55173951-55173951 + - PATHOGENIC .96084 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000415559.1:p.Ala653Thr ENST00000455089.5:c.1957G>A 7:g.55173951G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592889 1592889 1513815 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51789815 COSM133185 133220464 c.2051G>A p.G684E Substitution - Missense 38 7:55174723-55174723 + - PATHOGENIC .99879 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000415559.1:p.Gly684Glu ENST00000455089.5:c.2051G>A 7:g.55174723G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2579691 2579691 2441028 NS NS NS NS malignant_melanoma NS NS NS n COSV51786271 COSM6005743 133262485 c.1973T>A p.L658H Substitution - Missense 38 7:55173967-55173967 + - PATHOGENIC .8277 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000415559.1:p.Leu658His ENST00000455089.5:c.1973T>A 7:g.55173967T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2626134 2626134 2486546 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51791433 COSM6191492 133269572 c.752_753delinsTT p.P251L Substitution - Missense 38 7:55154150-55154151 + - Variant of unknown origin 26645239 surgery-fixed NS ENSP00000415559.1:p.Pro251Leu ENST00000455089.5:c.752_753delinsTT 7:g.55154150_55154151delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471797 1471797 1395535 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51849843 COSM53265 133281712 c.2421G>T p.K807N Substitution - Missense 38 7:55191805-55191805 + - PATHOGENIC .94296 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000415559.1:p.Lys807Asn ENST00000455089.5:c.2421G>T 7:g.55191805G>T EGFR ENST00000275493.6 3633 3236 DM16 2466857 2329688 skin head_neck NS NS malignant_melanoma desmoplastic NS NS n COSV51842833 COSM5608338 99428902 c.794C>T p.P265L Substitution - Missense 38 7:55154057-55154057 + - PATHOGENIC .98876 Variant of unknown origin 26343386 surgery-fixed NS 80 ENSP00000275493.2:p.Pro265Leu ENST00000275493.6:c.794C>T 7:g.55154057C>T EGFR ENST00000275493.6 3633 3236 1857882 1857882 1750372 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1169666 178380438 c.? p.P596L Substitution - Missense + - Variant of unknown origin 23243055 surgery-fixed recurrent ENSP00000275493.2:p.Pro596Leu EGFR ENST00000275493.6 3633 3236 1802323 1802323 1704042 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51802866 COSM1140059 99427144 c.2261A>T p.K754I Substitution - Missense het 38 7:55174798-55174798 + - PATHOGENIC .99276 Variant of unknown origin 23134665 surgery - NOS primary 52 ENSP00000275493.2:p.Lys754Ile ENST00000275493.6:c.2261A>T 7:g.55174798A>T EGFR ENST00000275493.6 3633 3236 WSU-HN30 2296299 2161902 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51845363 COSM4600429 99380587 c.316A>T p.I106F Substitution - Missense 38 7:55143380-55143380 + - PATHOGENIC .97255 Variant of unknown origin 25275298 cell-line NS ENSP00000275493.2:p.Ile106Phe ENST00000275493.6:c.316A>T 7:g.55143380A>T EGFR ENST00000275493.6 3633 3236 2344996 2344996 2209668 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1585368 1585368 1506689 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 22011666 blood-bone marrow recurrent EGFR ENST00000275493.6 3633 3236 2096197 2096197 1974261 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 1945218 1945218 1832128 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51769090 COSM1578128 99393255 c.2475G>A p.M825I Substitution - Missense 38 7:55191724-55191724 + - PATHOGENIC .98912 Variant of unknown origin 23295441 surgery-fixed NS ENSP00000275493.2:p.Met825Ile ENST00000275493.6:c.2475G>A 7:g.55191724G>A EGFR ENST00000275493.6 3633 3236 2630491 2630491 2490875 soft_tissue fibrous_tissue_and_uncertain_origin small_intestine NS gastrointestinal_stromal_tumour spindle NS NS n COSM20894 178379162 c.? p.A859T Substitution - Missense het + - Variant of unknown origin 28485054 surgery-fixed primary 64 ENSP00000275493.2:p.Ala859Thr EGFR ENST00000275493.6 3633 3236 2834130 2834130 2689914 skin mucosal anorectal NS malignant_melanoma NS NS NS y COSV104577202 COSM9320357 99409868 c.3622A>T p.I1208F Substitution - Missense 38 7:55205606-55205606 + - PATHOGENIC .94372 Variant of unknown origin 28296713 surgery - NOS primary 59 ENSP00000275493.2:p.Ile1208Phe ENST00000275493.6:c.3622A>T 7:g.55205606A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226770 2226770 2094505 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51789815 COSM133185 133220464 c.2051G>A p.G684E Substitution - Missense 38 7:55174723-55174723 + - PATHOGENIC .99879 Variant of unknown origin 24891042 NS NS ENSP00000415559.1:p.Gly684Glu ENST00000455089.5:c.2051G>A 7:g.55174723G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 VOA1947 2897843 2752142 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105864361 COSM9970409 133259074 c.835C>T p.R279C Substitution - Missense 38 7:55155910-55155910 + - PATHOGENIC .91299 Variant of unknown origin 31477716 surgery-fixed metastasis 69 ENSP00000415559.1:p.Arg279Cys ENST00000455089.5:c.835C>T 7:g.55155910C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1052732 1052732 968803 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51798115 COSM24268 133210677 c.2437_2438delinsAA p.L813K Substitution - Missense 38 7:55191821-55191822 + - Variant of unknown origin 17368623 NS NS ENSP00000415559.1:p.Leu813Lys ENST00000455089.5:c.2437_2438delinsAA 7:g.55191821_55191822delinsAA EGFR ENST00000275493.6 3633 3236 2626082 2626082 2486494 lung NS NS NS carcinoid-endocrine_tumour typical NS NS n COSV51813933 COSM6191488 99398096 c.2318A>C p.H773P Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98494 Variant of unknown origin 26645239 surgery-fixed NS ENSP00000275493.2:p.His773Pro ENST00000275493.6:c.2318A>C 7:g.55181327A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PGBM22 1630920 1547790 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51799872 COSM53266 133250183 c.2030C>T p.A677V Substitution - Missense 38 7:55174024-55174024 + - PATHOGENIC .97625 Variant of unknown origin 22286061 surgery - NOS NS ENSP00000415559.1:p.Ala677Val ENST00000455089.5:c.2030C>T 7:g.55174024C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914803 914803 832252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51806784 COSM12428 133224142 c.1990_1992delinsCAT p.E664H Substitution - Missense 38 7:55173984-55173986 + - Variant of unknown origin 15738541 surgery fresh/frozen recurrent ENSP00000415559.1:p.Glu664His ENST00000455089.5:c.1990_1992delinsCAT 7:g.55173984_55173986delinsCAT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-B0-5116-01 1779843 1683842 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51823166 COSM485465 133215448 c.2990G>A p.S997N Substitution - Missense hom 38 7:55201745-55201745 + - PATHOGENIC .98326 Variant of unknown origin 416 fresh/frozen - NOS primary 52 ENSP00000415559.1:p.Ser997Asn ENST00000455089.5:c.2990G>A 7:g.55201745G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2026146 2026146 1908235 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51807481 COSM1716255 133208224 c.2017C>A p.L673M Substitution - Missense 38 7:55174011-55174011 + - PATHOGENIC .91907 Variant of unknown origin 24040454 surgery-fixed NS ENSP00000415559.1:p.Leu673Met ENST00000455089.5:c.2017C>A 7:g.55174011C>A EGFR ENST00000275493.6 3633 3236 1086840 1086840 1001860 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM25842 178385658 c.? p.V689L Substitution - Missense + - Variant of unknown origin 17848912 blood-bone marrow NS 53 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1330080 1330080 1240565 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51809790 COSM41665 133208046 c.2366T>C p.V789A Substitution - Missense het 38 7:55191750-55191750 + - PATHOGENIC .97813 Variant of unknown origin 20208477 surgery - NOS NS ENSP00000415559.1:p.Val789Ala ENST00000455089.5:c.2366T>C 7:g.55191750T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043126 1043126 959467 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51776999 COSM22949 133237122 c.2450T>C p.L817P Substitution - Missense 38 7:55191834-55191834 + - PATHOGENIC .97782 Variant of unknown origin 17224267 surgery-fixed NS 23 ENSP00000415559.1:p.Leu817Pro ENST00000455089.5:c.2450T>C 7:g.55191834T>C EGFR ENST00000275493.6 3633 3236 1634406 1634406 1550911 lung right NS NS carcinoma adenocarcinoma NS NS n COSM20894 178379162 c.? p.A859T Substitution - Missense + - Variant of unknown origin 22325357 NS primary 62 ENSP00000275493.2:p.Ala859Thr EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-02-0116-01 1910165 1798456 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51795519 COSM35822 133281379 c.1654G>C p.A552P Substitution - Missense hom 38 7:55165346-55165346 + - NEUTRAL .2004 Variant of unknown origin 329 fresh/frozen - NOS primary 54 ENSP00000415559.1:p.Ala552Pro ENST00000455089.5:c.1654G>C 7:g.55165346G>C EGFR ENST00000275493.6 3633 3236 GTL-16 1945868 1832778 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51809237 COSM18445 99378456 c.3143C>T p.A1048V Substitution - Missense 38 7:55201763-55201763 + - NEUTRAL .41771 Variant of unknown origin 18186519 cell-line NS ENSP00000275493.2:p.Ala1048Val ENST00000275493.6:c.3143C>T 7:g.55201763C>T EGFR ENST00000275493.6 3633 3236 1489673 1489673 1412831 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 21155184 surgery-fixed primary EGFR ENST00000275493.6 3633 3236 PSP053164 2426650 2289571 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS n COSM29850 178384216 c.? p.A750P Substitution - Missense het + - Variant of unknown origin 24335104 blood-bone marrow recurrent 60 ENSP00000275493.2:p.Ala750Pro EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2728558 2728558 2587369 cervix NS NS NS carcinoma mesonephric_carcinoma NS NS n COSV51846371 COSM7338932 133253849 c.2783G>A p.R928Q Substitution - Missense 38 7:55200385-55200385 + - PATHOGENIC .99379 Variant of unknown origin 26336887 surgery-fixed primary 51 ENSP00000415559.1:p.Arg928Gln ENST00000455089.5:c.2783G>A 7:g.55200385G>A EGFR ENST00000275493.6 3633 3236 2096187 2096187 1974251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 2026282 2026282 1908371 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1716260 178388683 c.? p.L815P Substitution - Missense + - Variant of unknown origin 24040454 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 VOA1720 2897846 2752145 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105864482 COSM9969894 99440160 c.494G>C p.R165P Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .25613 Variant of unknown origin 31477716 surgery-fixed NS 73 ENSP00000275493.2:p.Arg165Pro ENST00000275493.6:c.494G>C 7:g.55146675G>C EGFR ENST00000275493.6 3633 3236 2264365 2264365 2131349 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR ENST00000275493.6 3633 3236 PD42091a 2894825 2749313 skin extremity NS NS malignant_melanoma superficial_spreading NS NS y COSV105110459 COSM9878542 99457426 c.2906C>T p.S969F Substitution - Missense 38 7:55200373-55200373 + - PATHOGENIC .97308 Variant of unknown origin 33024263 surgery-fixed metastasis 57 ENSP00000275493.2:p.Ser969Phe ENST00000275493.6:c.2906C>T 7:g.55200373C>T EGFR ENST00000275493.6 3633 3236 2406806 2406806 2269686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM27536 178380580 c.? p.H773Y Substitution - Missense + - Variant of unknown origin 23709419 surgery - NOS NS 61 ENSP00000275493.2:p.His773Tyr EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594589 1594589 1515557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51776191 COSM133565 133215541 c.2252G>A p.G751D Substitution - Missense 38 7:55181396-55181396 + - PATHOGENIC .96481 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000415559.1:p.Gly751Asp ENST00000455089.5:c.2252G>A 7:g.55181396G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1484294 1484294 1407920 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51771443 COSM12727 133206095 c.2416G>A p.V806I Substitution - Missense 38 7:55191800-55191800 + - PATHOGENIC .98898 Variant of unknown origin 21266046 surgery-fixed primary 67 ENSP00000415559.1:p.Val806Ile ENST00000455089.5:c.2416G>A 7:g.55191800G>A EGFR ENST00000275493.6 3633 3236 DM10 2466851 2329682 skin face NS NS malignant_melanoma desmoplastic NS NS n COSV51850876 COSM5608334 99391663 c.1357C>T p.L453F Substitution - Missense 38 7:55160197-55160197 + - PATHOGENIC .96542 Variant of unknown origin 26343386 surgery-fixed NS 70 ENSP00000275493.2:p.Leu453Phe ENST00000275493.6:c.1357C>T 7:g.55160197C>T EGFR ENST00000275493.6 3633 3236 BL-17-J45330 2905663 2759919 NS NS NS NS malignant_melanoma NS NS NS n COSV105864517 COSM9991398 99441667 c.3271G>A p.E1091K Substitution - Missense 38 7:55202625-55202625 + - PATHOGENIC .98023 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Glu1091Lys ENST00000275493.6:c.3271G>A 7:g.55202625G>A EGFR ENST00000275493.6 3633 3236 1658050 1658050 1572501 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM211764 178383848 c.? p.L703V Substitution - Missense + - Variant of unknown origin 22458769 surgery-fixed primary ENSP00000275493.2:p.Leu703Val EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2113069 2113069 1987330 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51788551 COSM214349 133220165 c.1936C>T p.P646S Substitution - Missense het 38 7:55173930-55173930 + - PATHOGENIC .98279 Variant of unknown origin 24595526 surgery-fixed NS ENSP00000415559.1:p.Pro646Ser ENST00000455089.5:c.1936C>T 7:g.55173930C>T EGFR ENST00000275493.6 3633 3236 2525695 2525695 2387884 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1235366 178384307 c.? p.G724S Substitution - Missense + - Variant of unknown origin 27304188 fine needle aspirate metastasis ENSP00000275493.2:p.Gly724Ser EGFR ENST00000275493.6 3633 3236 SK-MEL-28 1425350 1335378 skin NS NS NS malignant_melanoma NS NS NS n COSM49040 178380912 c.? p.P753S Substitution - Missense + - Variant of unknown origin 20406486 cell-line NS ENSP00000275493.2:p.Pro753Ser EGFR ENST00000275493.6 3633 3236 2426884 2426884 2289805 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM49040 178380912 c.? p.P753S Substitution - Missense + - Variant of unknown origin 25561229 NS NS ENSP00000275493.2:p.Pro753Ser EGFR ENST00000275493.6 3633 3236 1567523 1567523 1489155 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM131551 178378593 c.? p.L861E Substitution - Missense + - Variant of unknown origin 21949883 fine needle aspirate metastasis EGFR ENST00000275493.6 3633 3236 1551485 1551485 1473590 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM34160 178383469 c.? p.R831C Substitution - Missense + - Variant of unknown origin 21858063 surgery-fixed NS 76 ENSP00000275493.2:p.Arg831Cys EGFR ENST00000275493.6 3633 3236 2026217 2026217 1908306 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1716259 178385274 c.? p.V819E Substitution - Missense + - Variant of unknown origin 24040454 surgery-fixed NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471802 1471802 1395540 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51780223 COSM28511 133223277 c.1973T>C p.L658P Substitution - Missense 38 7:55173967-55173967 + - PATHOGENIC .90657 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000415559.1:p.Leu658Pro ENST00000455089.5:c.1973T>C 7:g.55173967T>C EGFR ENST00000275493.6 3633 3236 2585427 2585427 2446591 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51767869 COSM3266583 99377861 c.1351C>T p.R451C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 25623215 surgery - NOS recurrent ENSP00000275493.2:p.Arg451Cys ENST00000275493.6:c.1351C>T 7:g.55160191C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1661375 1661375 1574990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51788551 COSM214349 133220165 c.1936C>T p.P646S Substitution - Missense 38 7:55173930-55173930 + - PATHOGENIC .98279 Variant of unknown origin 22483783 surgery-fixed NS 82 ENSP00000415559.1:p.Pro646Ser ENST00000455089.5:c.1936C>T 7:g.55173930C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-08-0246-01 1910219 1798510 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51792876 COSM43066 133208367 c.632A>C p.D211A Substitution - Missense hom 38 7:55154030-55154030 + - PATHOGENIC .98125 Variant of unknown origin 329 fresh/frozen - NOS primary 57 ENSP00000415559.1:p.Asp211Ala ENST00000455089.5:c.632A>C 7:g.55154030A>C EGFR ENST00000275493.6 3633 3236 37 2760145 2618678 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51797913 COSM7339051 99383892 c.2505C>A p.H835Q Substitution - Missense 38 7:55191754-55191754 + - PATHOGENIC .83351 Variant of unknown origin 29876005 surgery-fixed NS ENSP00000275493.2:p.His835Gln ENST00000275493.6:c.2505C>A 7:g.55191754C>A EGFR ENST00000275493.6 3633 3236 2081827 2081827 1960249 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24481317 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2425785 2425785 2288706 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM26411 178380422 c.? p.S720F Substitution - Missense + - Variant of unknown origin 23724098 surgery-fixed NS ENSP00000275493.2:p.Ser720Phe EGFR ENST00000275493.6 3633 3236 2008803 2008803 1891537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1684685 178385387 c.? p.Q787R Substitution - Missense + - Variant of unknown origin 23961259 surgery-fixed NS ENSP00000275493.2:p.Gln787Arg EGFR ENST00000275493.6 3633 3236 1966251 1966251 1852744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1651657 178389829 c.? p.D830Y Substitution - Missense + - Variant of unknown origin 23800712 fixed - NOS NS EGFR ENST00000275493.6 3633 3236 2817999 2817999 2674298 lung right NS NS carcinoma adenocarcinoma NS NS n COSV104368882 COSM9263867 99424865 c.2359C>A p.Q787K Substitution - Missense 38 7:55181368-55181368 + - PATHOGENIC .97684 Variant of unknown origin 31422893 pleural effusion metastasis 72 ENSP00000275493.2:p.Gln787Lys ENST00000275493.6:c.2359C>A 7:g.55181368C>A EGFR ENST00000275493.6 3633 3236 11 2570179 2431476 skin face NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51775232 COSM5991527 99408324 c.2381C>T p.P794L Substitution - Missense 38 7:55181390-55181390 + - PATHOGENIC .96631 Variant of unknown origin 27311873 surgery-fixed NS 65 ENSP00000275493.2:p.Pro794Leu ENST00000275493.6:c.2381C>T 7:g.55181390C>T EGFR ENST00000275493.6 3633 3236 1587207 1587207 1508378 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21602 178380317 c.? p.L833V Substitution - Missense + - Variant of unknown origin 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu833Val EGFR ENST00000275493.6 3633 3236 1587207 1587207 1508378 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM133107 178380316 c.? p.H835L Substitution - Missense + - Variant of unknown origin 21841502 surgery-fixed NS ENSP00000275493.2:p.His835Leu EGFR ENST00000275493.6 3633 3236 2687132 2687132 2546114 breast NS NS NS carcinoma NS NS NS n COSV51783638 COSM28514 99409705 c.2495G>T p.R832L Substitution - Missense 38 7:55191744-55191744 + - PATHOGENIC .96073 Variant of unknown origin 27284958 surgery-fixed metastasis 67 ENSP00000275493.2:p.Arg832Leu ENST00000275493.6:c.2495G>T 7:g.55191744G>T EGFR ENST00000275493.6 3633 3236 1484348 1484348 1407974 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSM85902 178385732 c.? p.F856Y Substitution - Missense + - Variant of unknown origin 21266046 surgery-fixed primary 69 EGFR ENST00000275493.6 3633 3236 SK-MEL-186 2233677 2101260 skin NS NS NS malignant_melanoma NS NS NS n COSM4172570 178387923 c.? p.V1011M Substitution - Missense + - Variant of unknown origin 24628946 cell-line NS ENSP00000275493.2:p.Val1011Met EGFR ENST00000275493.6 3633 3236 1484356 1484356 1407982 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSM85898 178380893 c.? p.Q820R Substitution - Missense + - Variant of unknown origin 21266046 surgery-fixed primary 69 ENSP00000275493.2:p.Gln820Arg EGFR ENST00000275493.6 3633 3236 897801 897801 815423 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51806784 COSM12428 99398840 c.2125_2127delinsCAT p.E709H Substitution - Missense 38 7:55173984-55173986 + - Variant of unknown origin 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Glu709His ENST00000275493.6:c.2125_2127delinsCAT 7:g.55173984_55173986delinsCAT EGFR ENST00000275493.6 3633 3236 1166428 1166428 1078742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773237 COSM28609 99411858 c.2416A>G p.K806E Substitution - Missense het 38 7:55181425-55181425 + - PATHOGENIC .9712 Variant of unknown origin 16870303 surgery - NOS NS 67 ENSP00000275493.2:p.Lys806Glu ENST00000275493.6:c.2416A>G 7:g.55181425A>G EGFR ENST00000275493.6 3633 3236 1484332 1484332 1407958 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSM85901 178379619 c.? p.L828M Substitution - Missense + - Variant of unknown origin 21266046 surgery-fixed primary 68 EGFR ENST00000275493.6 3633 3236 1135352 1135352 1047918 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM21603 178379091 c.? p.R776H Substitution - Missense + - Variant of unknown origin 17591931 surgery - NOS NS ENSP00000275493.2:p.Arg776His EGFR ENST00000275493.6 3633 3236 2905803 2905803 2760055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21603 178379091 c.? p.R776H Substitution - Missense + - Variant of unknown origin 33608032 circulating tumour metastasis 50 ENSP00000275493.2:p.Arg776His EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098817 1098817 1013409 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 133208531 c.2477C>G p.A826G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 18176089 surgery fresh/frozen primary 51 ENSP00000415559.1:p.Ala826Gly ENST00000455089.5:c.2477C>G 7:g.55191861C>G EGFR ENST00000275493.6 3633 3236 1668669 1668669 1581961 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM219796 178389947 c.? p.A871V Substitution - Missense + - Variant of unknown origin 22523351 fixed - NOS NS ENSP00000275493.2:p.Ala871Val EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1656008 1656008 1570665 peritoneum NS NS NS mesothelioma NS NS NS n COSV51844929 COSM211635 133264710 c.2413C>T p.H805Y Substitution - Missense het 38 7:55191797-55191797 + - PATHOGENIC .97885 Variant of unknown origin 22426987 surgery-fixed NS 58 ENSP00000415559.1:p.His805Tyr ENST00000455089.5:c.2413C>T 7:g.55191797C>T EGFR ENST00000275493.6 3633 3236 2345036 2345036 2209708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2026149 2026149 1908238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51785295 COSM1716257 133253252 c.2191C>A p.R731S Substitution - Missense het 38 7:55181335-55181335 + - PATHOGENIC .9754 Variant of unknown origin 24040454 surgery-fixed NS ENSP00000415559.1:p.Arg731Ser ENST00000455089.5:c.2191C>A 7:g.55181335C>A EGFR ENST00000275493.6 3633 3236 1567518 1567518 1489150 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM131550 178379318 c.? p.H805L Substitution - Missense + - Variant of unknown origin 21949883 fine needle aspirate metastasis EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592876 1592876 1513802 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51825508 COSM133181 133215400 c.1952G>A p.G651E Substitution - Missense 38 7:55173946-55173946 + - PATHOGENIC .98116 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000415559.1:p.Gly651Glu ENST00000455089.5:c.1952G>A 7:g.55173946G>A EGFR ENST00000275493.6 3633 3236 2778588 2778588 2636642 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51773889 COSM14069 99414148 c.2348C>T p.T783I Substitution - Missense 38 7:55181357-55181357 + - PATHOGENIC .96109 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000275493.2:p.Thr783Ile ENST00000275493.6:c.2348C>T 7:g.55181357C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1074944 1074944 990198 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51811855 COSM24848 133241725 c.2446C>G p.L816V Substitution - Missense 38 7:55191830-55191830 + - PATHOGENIC .93198 Variant of unknown origin 17573511 fine needle aspirate metastasis 67 ENSP00000415559.1:p.Leu816Val ENST00000455089.5:c.2446C>G 7:g.55191830C>G EGFR ENST00000275493.6 3633 3236 2011076 2011076 1893714 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1235366 178384307 c.? p.G724S Substitution - Missense + - Variant of unknown origin 24002608 surgery - NOS NS ENSP00000275493.2:p.Gly724Ser EGFR ENST00000275493.6 3633 3236 1914968 1914968 1802970 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 23590575 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2595758 2595758 2456634 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 27538584 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2345019 2345019 2209691 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2069204 2069204 1948779 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM27111 178379606 c.? p.A871G Substitution - Missense + - Variant of unknown origin 24346091 NS metastasis ENSP00000275493.2:p.Ala871Gly EGFR ENST00000275493.6 3633 3236 1594587 1594587 1515555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772325 COSM133628 99453069 c.2353A>C p.T785P Substitution - Missense 38 7:55181362-55181362 + - PATHOGENIC .91002 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000275493.2:p.Thr785Pro ENST00000275493.6:c.2353A>C 7:g.55181362A>C EGFR ENST00000275493.6 3633 3236 1837419 1837419 1731618 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM27111 178379606 c.? p.A871G Substitution - Missense + - Variant of unknown origin 23242437 NS NS 66 ENSP00000275493.2:p.Ala871Gly EGFR ENST00000275493.6 3633 3236 DM8 2466885 2329716 skin scalp NS NS malignant_melanoma desmoplastic NS NS n COSV51853062 COSM5611261 99382930 c.3137_3138delinsTT p.T1046I Substitution - Missense 38 7:55201757-55201758 + - Variant of unknown origin 26343386 surgery-fixed NS 81 ENSP00000275493.2:p.Thr1046Ile ENST00000275493.6:c.3137_3138delinsTT 7:g.55201757_55201758delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-78-7147-01 1914054 1802336 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51797369 COSM6178060 133256752 c.1024C>A p.L342M Substitution - Missense 38 7:55156784-55156784 + - PATHOGENIC .85999 Variant of unknown origin 417 fresh/frozen - NOS primary 67 ENSP00000415559.1:p.Leu342Met ENST00000455089.5:c.1024C>A 7:g.55156784C>A EGFR ENST00000275493.6 3633 3236 1592874 1592874 1513800 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51790353 COSM13178 99450942 c.2081C>T p.P694L Substitution - Missense 38 7:55173940-55173940 + - PATHOGENIC .97388 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000275493.2:p.Pro694Leu ENST00000275493.6:c.2081C>T 7:g.55173940C>T EGFR ENST00000275493.6 3633 3236 TCGA-05-5423-01 1780079 1684078 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51787416 COSM219794 99382078 c.2499G>T p.L833F Substitution - Missense 38 7:55191748-55191748 + - PATHOGENIC .95793 Variant of unknown origin 417 fresh/frozen - NOS primary 65 ENSP00000275493.2:p.Leu833Phe ENST00000275493.6:c.2499G>T 7:g.55191748G>T EGFR ENST00000275493.6 3633 3236 NPC0001PT00226T00226 2857365 2712665 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 99406505 c.1162G>A p.D388N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000275493.2:p.Asp388Asn ENST00000275493.6:c.1162G>A 7:g.55156787G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 911620 911620 829103 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51771443 COSM12727 133206095 c.2416G>A p.V806I Substitution - Missense 38 7:55191800-55191800 + - PATHOGENIC .98898 Variant of unknown origin 15870435 surgery-fixed primary ENSP00000415559.1:p.Val806Ile ENST00000455089.5:c.2416G>A 7:g.55191800G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NAN8 2809783 2666453 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV99289304 COSM9153919 133230370 c.535C>T p.R179C Substitution - Missense het 38 7:55152587-55152587 + - PATHOGENIC .90413 Variant of unknown origin 30545397 cell-line primary ENSP00000415559.1:p.Arg179Cys ENST00000455089.5:c.535C>T 7:g.55152587C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NAN8 2809783 2666453 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV99289308 COSM9153923 133230393 c.1918G>C p.E640Q Substitution - Missense het 38 7:55173116-55173116 + - PATHOGENIC .99493 Variant of unknown origin 30545397 cell-line primary ENSP00000415559.1:p.Glu640Gln ENST00000455089.5:c.1918G>C 7:g.55173116G>C EGFR ENST00000275493.6 3633 3236 1484303 1484303 1407929 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSM85900 178386350 c.? p.A839V Substitution - Missense + - Variant of unknown origin 21266046 surgery-fixed primary 67 ENSP00000275493.2:p.Ala839Val EGFR ENST00000275493.6 3633 3236 1974004 1974004 1860246 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51800006 COSM1651734 99419597 c.2404G>A p.V802I Substitution - Missense 38 7:55181413-55181413 + - PATHOGENIC .8748 Variant of unknown origin 23584298 surgery - NOS NS ENSP00000275493.2:p.Val802Ile ENST00000275493.6:c.2404G>A 7:g.55181413G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 AMO1 2809758 2666428 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasmacytoma NS NS y COSV51777457 COSM1236015 133227966 c.492A>C p.K164N Substitution - Missense het 38 7:55151361-55151361 + - NEUTRAL .14933 Variant of unknown origin 30545397 cell-line NS ENSP00000415559.1:p.Lys164Asn ENST00000455089.5:c.492A>C 7:g.55151361A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MBC531 2807310 2664014 breast NS NS NS carcinoma NS NS NS n COSV99286738 COSM9120811 133281734 c.1084A>G p.I362V Substitution - Missense 38 7:55157674-55157674 + - PATHOGENIC .99284 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000415559.1:p.Ile362Val ENST00000455089.5:c.1084A>G 7:g.55157674A>G EGFR ENST00000275493.6 3633 3236 2522581 2522581 2384900 endometrium NS NS NS carcinoma adenocarcinoma NS NS n COSM5881412 178389365 c.? p.T605A Substitution - Missense + - Variant of unknown origin 27170661 surgery-fixed metastasis 60 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2113075 2113075 1987336 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51772282 COSM133202 133212823 c.2201G>A p.G734D Substitution - Missense het 38 7:55181345-55181345 + - PATHOGENIC .98244 Variant of unknown origin 24595526 surgery-fixed NS ENSP00000415559.1:p.Gly734Asp ENST00000455089.5:c.2201G>A 7:g.55181345G>A EGFR ENST00000275493.6 3633 3236 TCGA-70-6722-01 1783058 1687057 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51807303 COSM747424 99375979 c.2527G>T p.V843L Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .9903 Variant of unknown origin 418 fresh/frozen - NOS primary 47 ENSP00000275493.2:p.Val843Leu ENST00000275493.6:c.2527G>T 7:g.55191776G>T EGFR ENST00000275493.6 3633 3236 2000148 2000148 1885046 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1667028 178390471 c.? p.K757R Substitution - Missense + - Variant of unknown origin 23945384 surgery-fixed NS ENSP00000275493.2:p.Lys757Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1333424 1333424 1243898 salivary_gland parotid NS NS carcinoma salivary_duct_carcinoma NS NS n COSV51807685 COSM13177 133220110 c.1928T>C p.L643P Substitution - Missense 38 7:55173922-55173922 + - PATHOGENIC .97819 Variant of unknown origin 20371674 surgery-fixed NS 61 ENSP00000415559.1:p.Leu643Pro ENST00000455089.5:c.1928T>C 7:g.55173922T>C EGFR ENST00000275493.6 3633 3236 2672936 2672936 2532449 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1716337 178378584 c.? p.A289V Substitution - Missense + - Variant of unknown origin 26191234 surgery-fixed primary ENSP00000275493.2:p.Ala289Val EGFR ENST00000275493.6 3633 3236 946830 946830 863353 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51866933 COSM14071 99452339 c.2689G>A p.V897I Substitution - Missense 38 7:55192829-55192829 + - PATHOGENIC .96332 Variant of unknown origin 16204011 surgery-fixed NS ENSP00000275493.2:p.Val897Ile ENST00000275493.6:c.2689G>A 7:g.55192829G>A EGFR ENST00000275493.6 3633 3236 1047800 1047800 964029 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51774943 COSM23611 99416471 c.2453G>A p.C818Y Substitution - Missense 38 7:55181462-55181462 + - PATHOGENIC .97439 Variant of unknown origin 17354229 surgery-fixed NS 60 ENSP00000275493.2:p.Cys818Tyr ENST00000275493.6:c.2453G>A 7:g.55181462G>A EGFR ENST00000275493.6 3633 3236 ESO-721 1890961 1780330 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV51788608 COSM1251016 99392900 c.1340C>A p.S447Y Substitution - Missense 38 7:55160180-55160180 + - .5293 Variant of unknown origin 23525077 surgery fresh/frozen primary 68 ENSP00000275493.2:p.Ser447Tyr ENST00000275493.6:c.1340C>A 7:g.55160180C>A EGFR ENST00000275493.6 3633 3236 H1793 2776325 2634461 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51866889 COSM3266567 99388858 c.932G>T p.C311F Substitution - Missense 38 7:55155872-55155872 + - PATHOGENIC .99418 Variant of unknown origin 29681454 NS NS 52 ENSP00000275493.2:p.Cys311Phe ENST00000275493.6:c.932G>T 7:g.55155872G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1330079 1330079 1240564 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51847775 COSM41663 133227649 c.2327T>C p.I776T Substitution - Missense 38 7:55181471-55181471 + - PATHOGENIC .92352 Variant of unknown origin 20208477 surgery - NOS NS ENSP00000415559.1:p.Ile776Thr ENST00000455089.5:c.2327T>C 7:g.55181471T>C EGFR ENST00000275493.6 3633 3236 2029033 2029033 1910915 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1716334 178380890 c.? p.L707F Substitution - Missense het + - Variant of unknown origin 23628817 NS NS EGFR ENST00000275493.6 3633 3236 899356 899356 816968 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51866714 COSM12372 99455799 c.2144T>G p.I715S Substitution - Missense 38 7:55174003-55174003 + - PATHOGENIC .88145 Variant of unknown origin 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Ile715Ser ENST00000275493.6:c.2144T>G 7:g.55174003T>G EGFR ENST00000275493.6 3633 3236 BL-18-T42044 2905562 2759818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864537 COSM10001654 99443991 c.3244A>T p.I1082L Substitution - Missense 38 7:55202598-55202598 + - NEUTRAL .15191 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Ile1082Leu ENST00000275493.6:c.3244A>T 7:g.55202598A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1523089 1523089 1445461 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51813062 COSM12764 133203122 c.2434G>A p.G812R Substitution - Missense het 38 7:55191818-55191818 + - PATHOGENIC .98898 Variant of unknown origin 21284055 surgery-fixed NS ENSP00000415559.1:p.Gly812Arg ENST00000455089.5:c.2434G>A 7:g.55191818G>A EGFR ENST00000275493.6 3633 3236 1166428 1166428 1078742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773222 COSM28608 99411852 c.2393T>A p.L798H Substitution - Missense het 38 7:55181402-55181402 + - PATHOGENIC .95568 Variant of unknown origin 16870303 surgery - NOS NS 67 ENSP00000275493.2:p.Leu798His ENST00000275493.6:c.2393T>A 7:g.55181402T>A EGFR ENST00000275493.6 3633 3236 2585232 2585232 2446396 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSM6009005 178385210 c.? p.R451C Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Arg451Cys EGFR ENST00000275493.6 3633 3236 TCGA-95-7947-01 1914103 1802385 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51819914 COSM6178048 99384413 c.3155G>T p.R1052I Substitution - Missense 38 7:55201775-55201775 + - PATHOGENIC .971 Variant of unknown origin 417 fresh/frozen - NOS primary 67 ENSP00000275493.2:p.Arg1052Ile ENST00000275493.6:c.3155G>T 7:g.55201775G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1945218 1945218 1832128 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51769090 COSM1578128 133220528 c.2340G>A p.M780I Substitution - Missense 38 7:55191724-55191724 + - PATHOGENIC .98912 Variant of unknown origin 23295441 surgery-fixed NS ENSP00000415559.1:p.Met780Ile ENST00000455089.5:c.2340G>A 7:g.55191724G>A EGFR ENST00000275493.6 3633 3236 1024771 1024771 941748 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21602 178380317 c.? p.L833V Substitution - Missense + - Variant of unknown origin 17020982 surgery fresh/frozen metastasis ENSP00000275493.2:p.Leu833Val EGFR ENST00000275493.6 3633 3236 2000072 2000072 1884970 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1235366 178384307 c.? p.G724S Substitution - Missense + - Variant of unknown origin 23945384 surgery-fixed NS ENSP00000275493.2:p.Gly724Ser EGFR ENST00000275493.6 3633 3236 1330079 1330079 1240564 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51847775 COSM41663 99402092 c.2462T>C p.I821T Substitution - Missense 38 7:55181471-55181471 + - PATHOGENIC .92352 Variant of unknown origin 20208477 surgery - NOS NS ENSP00000275493.2:p.Ile821Thr ENST00000275493.6:c.2462T>C 7:g.55181471T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1802323 1802323 1704042 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51802866 COSM1140059 133250629 c.2126A>T p.K709I Substitution - Missense het 38 7:55174798-55174798 + - PATHOGENIC .99276 Variant of unknown origin 23134665 surgery - NOS primary 52 ENSP00000415559.1:p.Lys709Ile ENST00000455089.5:c.2126A>T 7:g.55174798A>T EGFR ENST00000275493.6 3633 3236 G45 1179740 1091702 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51815137 COSM28943 99419950 c.2297T>C p.M766T Substitution - Missense 38 7:55181306-55181306 + - PATHOGENIC .97686 Variant of unknown origin 19096301 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Met766Thr ENST00000275493.6:c.2297T>C 7:g.55181306T>C EGFR ENST00000275493.6 3633 3236 DM51 2466875 2329706 skin neck NS NS malignant_melanoma desmoplastic NS NS n COSV51774157 COSM5608355 99428041 c.1806A>T p.E602D Substitution - Missense 38 7:55165363-55165363 + - PATHOGENIC .71202 Variant of unknown origin 26343386 surgery-fixed NS 88 ENSP00000275493.2:p.Glu602Asp ENST00000275493.6:c.1806A>T 7:g.55165363A>T EGFR ENST00000275493.6 3633 3236 BL-15-W23729 2905323 2759579 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51801258 COSM13553 99388229 c.2572_2573inv p.L858R Substitution - Missense 38 7:55191821-55191822 + - Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2572_2573inv 7:g.55191821_55191822inv EGFR ENST00000275493.6 3633 3236 1746450 1746450 1651426 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 22895145 NS NS 70 EGFR ENST00000275493.6 3633 3236 2345117 2345117 2209789 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778588 2778588 2636642 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51773889 COSM14069 133240281 c.2213C>T p.T738I Substitution - Missense 38 7:55181357-55181357 + - PATHOGENIC .96109 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000415559.1:p.Thr738Ile ENST00000455089.5:c.2213C>T 7:g.55181357C>T EGFR ENST00000275493.6 3633 3236 2241831 2241831 2109362 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25228365 NS primary EGFR ENST00000275493.6 3633 3236 2750884 2750884 2609580 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 27086595 surgery-fixed NS 62 EGFR ENST00000275493.6 3633 3236 2345031 2345031 2209703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2131893 2131893 2005957 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419415 NS NS 68 EGFR ENST00000275493.6 3633 3236 2000069 2000069 1884967 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1667022 178385500 c.? p.T854A Substitution - Missense + - Variant of unknown origin 23945384 surgery-fixed NS 55 ENSP00000275493.2:p.Thr854Ala EGFR ENST00000275493.6 3633 3236 2675155 2675155 2534429 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766300 COSM6849765 99377570 c.2237A>G p.E746G Substitution - Missense 38 7:55174774-55174774 + - PATHOGENIC .97324 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000275493.2:p.Glu746Gly ENST00000275493.6:c.2237A>G 7:g.55174774A>G EGFR ENST00000275493.6 3633 3236 BL-17-M28272 2905583 2759839 urinary_tract NS NS NS carcinoma transitional_cell_carcinoma NS NS n COSV105864105 COSM9996772 99409289 c.2057G>A p.R686K Substitution - Missense 38 7:55173120-55173120 + - PATHOGENIC .99376 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Arg686Lys ENST00000275493.6:c.2057G>A 7:g.55173120G>A EGFR ENST00000275493.6 3633 3236 2156961 2156961 2025936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24828666 fixed - NOS NS 74 EGFR ENST00000275493.6 3633 3236 1914966 1914966 1802968 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 23590575 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2096277 2096277 1974341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 1638677 1638677 1554676 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 22321542 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1974004 1974004 1860246 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51800018 COSM1651735 99419604 c.2555A>G p.K852R Substitution - Missense 38 7:55191804-55191804 + - PATHOGENIC .97982 Variant of unknown origin 23584298 surgery - NOS NS ENSP00000275493.2:p.Lys852Arg ENST00000275493.6:c.2555A>G 7:g.55191804A>G EGFR ENST00000275493.6 3633 3236 2672941 2672941 2532450 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1169666 178380438 c.? p.P596L Substitution - Missense + - Variant of unknown origin 26191234 surgery-fixed primary ENSP00000275493.2:p.Pro596Leu EGFR ENST00000275493.6 3633 3236 1733680 1733680 1639629 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM256025 178386343 c.? p.L861G Substitution - Missense + - Variant of unknown origin 22836289 surgery-fixed NS 70 EGFR ENST00000275493.6 3633 3236 2290053 2290053 2156118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51804114 COSM4424126 99436519 c.2105C>T p.A702V Substitution - Missense het 38 7:55173964-55173964 + - PATHOGENIC .97446 Variant of unknown origin 16740761 surgery - NOS NS 50 ENSP00000275493.2:p.Ala702Val ENST00000275493.6:c.2105C>T 7:g.55173964C>T EGFR ENST00000275493.6 3633 3236 1875148 1875148 1765739 upper_aerodigestive_tract pharynx epiglottis NS carcinoma squamous_cell_carcinoma NS NS n COSM133107 178380316 c.? p.H835L Substitution - Missense + - Variant of unknown origin 23139256 fixed - NOS NS ENSP00000275493.2:p.His835Leu EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5347 915985 833384 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51867018 COSM13191 133279006 c.2257C>T p.L753F Substitution - Missense 38 7:55181401-55181401 + - PATHOGENIC .94619 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000415559.1:p.Leu753Phe ENST00000455089.5:c.2257C>T 7:g.55181401C>T EGFR ENST00000275493.6 3633 3236 1857884 1857884 1750374 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_III anaplastic NS n COSM1169666 178380438 c.? p.P596L Substitution - Missense + - Variant of unknown origin 23243055 surgery-fixed NS ENSP00000275493.2:p.Pro596Leu EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00226T00226 2857365 2712665 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 133232898 c.1027G>A p.D343N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000415559.1:p.Asp343Asn ENST00000455089.5:c.1027G>A 7:g.55156787G>A EGFR ENST00000275493.6 3633 3236 2522589 2522589 2384908 endometrium NS NS NS carcinoma adenocarcinoma NS NS n COSM5881413 178385455 c.? p.I462M Substitution - Missense + - Variant of unknown origin 27170661 surgery-fixed metastasis 50 EGFR ENST00000275493.6 3633 3236 2131910 2131910 2005973 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM27102 178381922 c.? p.R831H Substitution - Missense + - Variant of unknown origin 24376723 fine needle aspirate metastasis ENSP00000275493.2:p.Arg831His EGFR ENST00000275493.6 3633 3236 907089 1007167 924375 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM20961 178382552 c.? p.V819A Substitution - Missense + - Variant of unknown origin 16638863 NS NS EGFR ENST00000275493.6 3633 3236 4988 915987 833386 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51866608 COSM13193 99442332 c.2477A>G p.N826S Substitution - Missense 38 7:55191726-55191726 + - PATHOGENIC .9015 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000275493.2:p.Asn826Ser ENST00000275493.6:c.2477A>G 7:g.55191726A>G EGFR ENST00000275493.6 3633 3236 2425770 2425770 2288691 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1235285 178388032 c.? p.G796S Substitution - Missense + - Variant of unknown origin 23724098 surgery-fixed NS ENSP00000275493.2:p.Gly796Ser EGFR ENST00000275493.6 3633 3236 81_1 2605105 2465996 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM6056886 178380139 c.? p.D761N Substitution - Missense + - Variant of unknown origin 25376516 surgery - NOS NS 75 ENSP00000275493.2:p.Asp761Asn EGFR ENST00000275493.6 3633 3236 2732914 2732914 2591667 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827181 COSM7002280 99429261 c.574C>G p.P192A Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .86378 Variant of unknown origin 28855349 surgery - NOS primary 58 ENSP00000275493.2:p.Pro192Ala ENST00000275493.6:c.574C>G 7:g.55151308C>G EGFR ENST00000275493.6 3633 3236 2595754 2595754 2456630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 27538584 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2118476 2118476 1992711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24568474 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2344990 2344990 2209662 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1587199 1587199 1508370 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM133111 178387107 c.? p.L862V Substitution - Missense + - Variant of unknown origin 21841502 surgery-fixed NS 54 EGFR ENST00000275493.6 3633 3236 UCHRNP3 2682251 2541524 large_intestine NS NS NS other ulcerative_colitis NS NS n COSV51799562 COSM6854575 99404369 c.3041A>G p.D1014G Substitution - Missense 38 7:55201282-55201282 + - PATHOGENIC .9951 Variant of unknown origin 28524162 surgery fresh/frozen NS 31 ENSP00000275493.2:p.Asp1014Gly ENST00000275493.6:c.3041A>G 7:g.55201282A>G EGFR ENST00000275493.6 3633 3236 1729749 1729749 1635720 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM131550 178379318 c.? p.H805L Substitution - Missense + - Variant of unknown origin 22805266 NS NS EGFR ENST00000275493.6 3633 3236 MYL-044 2672908 2532427 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS n COSM6848493 178380789 c.? p.C624Y Substitution - Missense + - Variant of unknown origin 28492226 circulating tumour NS EGFR ENST00000275493.6 3633 3236 1729752 1729752 1635723 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM27103 178383328 c.? p.T847I Substitution - Missense + - Variant of unknown origin 22805266 NS NS ENSP00000275493.2:p.Thr847Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DM16 2466857 2329688 skin head_neck NS NS malignant_melanoma desmoplastic NS NS n COSV51842833 COSM5608338 133252297 c.659C>T p.P220L Substitution - Missense 38 7:55154057-55154057 + - PATHOGENIC .98876 Variant of unknown origin 26343386 surgery-fixed NS 80 ENSP00000415559.1:p.Pro220Leu ENST00000455089.5:c.659C>T 7:g.55154057C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593034 1593034 1513960 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51770642 COSM22992 133209132 c.2026G>A p.G676S Substitution - Missense 38 7:55174020-55174020 + - PATHOGENIC .98289 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000415559.1:p.Gly676Ser ENST00000455089.5:c.2026G>A 7:g.55174020G>A EGFR ENST00000275493.6 3633 3236 2000071 2000071 1884969 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM30756 178386019 c.? p.L861F Substitution - Missense + - Variant of unknown origin 23945384 surgery-fixed NS 57 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 7199 2897738 2752037 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105864119 COSM9964764 133237602 c.3004G>A p.V1002M Substitution - Missense 38 7:55201759-55201759 + - NEUTRAL .28639 Variant of unknown origin 31477716 surgery-fixed metastasis 51 ENSP00000415559.1:p.Val1002Met ENST00000455089.5:c.3004G>A 7:g.55201759G>A EGFR ENST00000275493.6 3633 3236 Mel-RMU-DR4 1941944 1828866 skin NS NS NS malignant_melanoma NS NS NS n COSM49040 178380912 c.? p.P753S Substitution - Missense + - Variant of unknown origin 22437314 cell-line NS ENSP00000275493.2:p.Pro753Ser EGFR ENST00000275493.6 3633 3236 1879231 1879231 1769786 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51800685 COSM1235323 99442041 c.2392C>G p.L798V Substitution - Missense 38 7:55181401-55181401 + - PATHOGENIC .96187 Variant of unknown origin 23468066 fine needle aspirate NS 73 ENSP00000275493.2:p.Leu798Val ENST00000275493.6:c.2392C>G 7:g.55181401C>G EGFR ENST00000275493.6 3633 3236 1840077 1840077 1733789 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM133108 178378894 c.? p.R831L Substitution - Missense + - Variant of unknown origin 23277327 fine needle aspirate NS EGFR ENST00000275493.6 3633 3236 1166428 1166428 1078742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773249 COSM28610 99411864 c.2441T>C p.L814P Substitution - Missense het 38 7:55181450-55181450 + - PATHOGENIC .94523 Variant of unknown origin 16870303 surgery - NOS NS 67 ENSP00000275493.2:p.Leu814Pro ENST00000275493.6:c.2441T>C 7:g.55181450T>C EGFR ENST00000275493.6 3633 3236 GBC_6 2907852 2762035 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV105864473 COSM10029109 99440467 c.1360A>G p.K454E Substitution - Missense 38 7:55160200-55160200 + - PATHOGENIC .95086 Variant of unknown origin 33563892 surgery-fixed NS 85 ENSP00000275493.2:p.Lys454Glu ENST00000275493.6:c.1360A>G 7:g.55160200A>G EGFR ENST00000275493.6 3633 3236 2226861 2226861 2094596 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51784727 COSM53227 99414142 c.2506C>A p.R836S Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .95567 Variant of unknown origin 24891042 NS NS ENSP00000275493.2:p.Arg836Ser ENST00000275493.6:c.2506C>A 7:g.55191755C>A EGFR ENST00000275493.6 3633 3236 2131910 2131910 2005973 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM3718341 178390107 c.? p.G721W Substitution - Missense + - Variant of unknown origin 24376723 fine needle aspirate metastasis EGFR ENST00000275493.6 3633 3236 2585238 2585238 2446402 large_intestine colon right NS carcinoma adenocarcinoma NS NS n COSM6009001 178378911 c.? p.S464L Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Ser464Leu EGFR ENST00000275493.6 3633 3236 1638676 1638676 1554675 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 22321542 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1734095 1734095 1640044 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 22842370 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2083479 2083479 1961762 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM1738010 178390104 c.? p.E749K Substitution - Missense + - Variant of unknown origin 24481316 surgery - NOS primary 59 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 H1793 2776325 2634461 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51866889 COSM3266567 133216771 c.797G>T p.C266F Substitution - Missense 38 7:55155872-55155872 + - PATHOGENIC .99418 Variant of unknown origin 29681454 NS NS 52 ENSP00000415559.1:p.Cys266Phe ENST00000455089.5:c.797G>T 7:g.55155872G>T EGFR ENST00000275493.6 3633 3236 1966251 1966251 1852744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1651658 178389828 c.? p.V834A Substitution - Missense + - Variant of unknown origin 23800712 fixed - NOS NS ENSP00000275493.2:p.Val834Ala EGFR ENST00000275493.6 3633 3236 1668671 1668671 1581963 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM26411 178380422 c.? p.S720F Substitution - Missense + - Variant of unknown origin 22523351 fixed - NOS NS ENSP00000275493.2:p.Ser720Phe EGFR ENST00000275493.6 3633 3236 2364046 2364046 2226960 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM4984831 178390195 c.? p.L707W Substitution - Missense + - Variant of unknown origin 25567908 surgery-fixed NS 41 ENSP00000275493.2:p.Leu707Trp EGFR ENST00000275493.6 3633 3236 1122171 1122171 1035215 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM27111 178379606 c.? p.A871G Substitution - Missense + - Variant of unknown origin 18418018 surgery - NOS NS 51 ENSP00000275493.2:p.Ala871Gly EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2626082 2626082 2486494 lung NS NS NS carcinoid-endocrine_tumour typical NS NS n COSV51813933 COSM6191488 133223626 c.2183A>C p.H728P Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98494 Variant of unknown origin 26645239 surgery-fixed NS ENSP00000415559.1:p.His728Pro ENST00000455089.5:c.2183A>C 7:g.55181327A>C EGFR ENST00000275493.6 3633 3236 2425772 2425772 2288693 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM28619 178383742 c.? p.V786M Substitution - Missense + - Variant of unknown origin 23724098 surgery-fixed NS ENSP00000275493.2:p.Val786Met EGFR ENST00000275493.6 3633 3236 BL-17-N27113 2905421 2759677 gastrointestinal_tract_(site_indeterminate) NS NS NS carcinoma NS NS NS n COSV105864561 COSM9997503 99446575 c.3250G>A p.D1084N Substitution - Missense 38 7:55202604-55202604 + - PATHOGENIC .96545 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000275493.2:p.Asp1084Asn ENST00000275493.6:c.3250G>A 7:g.55202604G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 WSU-HN30 2296299 2161902 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51845363 COSM4600429 133208791 c.316A>T p.I106F Substitution - Missense 38 7:55143380-55143380 + - PATHOGENIC .97255 Variant of unknown origin 25275298 cell-line NS ENSP00000415559.1:p.Ile106Phe ENST00000455089.5:c.316A>T 7:g.55143380A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226861 2226861 2094596 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51784727 COSM53227 133240277 c.2371C>A p.R791S Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .95567 Variant of unknown origin 24891042 NS NS ENSP00000415559.1:p.Arg791Ser ENST00000455089.5:c.2371C>A 7:g.55191755C>A EGFR ENST00000275493.6 3633 3236 1839252 1839252 1733353 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51828195 COSM13180 99405775 c.2188C>T p.L730F Substitution - Missense 38 7:55174725-55174725 + - PATHOGENIC .96849 Variant of unknown origin 23244191 surgery-fixed primary ENSP00000275493.2:p.Leu730Phe ENST00000275493.6:c.2188C>T 7:g.55174725C>T EGFR ENST00000275493.6 3633 3236 2522587 2522587 2384906 endometrium NS NS NS carcinoma adenocarcinoma NS NS n COSM5881413 178385455 c.? p.I462M Substitution - Missense + - Variant of unknown origin 27170661 surgery-fixed primary 50 EGFR ENST00000275493.6 3633 3236 2096204 2096204 1974268 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 2345007 2345007 2209679 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 3584 915990 833389 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51863898 COSM13196 99460488 c.2558T>C p.I853T Substitution - Missense 38 7:55191807-55191807 + - PATHOGENIC .97798 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000275493.2:p.Ile853Thr ENST00000275493.6:c.2558T>C 7:g.55191807T>C EGFR ENST00000275493.6 3633 3236 1964334 1964334 1850869 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM34155 178380594 c.? p.V769M Substitution - Missense + - Variant of unknown origin 23749122 NS NS ENSP00000275493.2:p.Val769Met EGFR ENST00000275493.6 3633 3236 1523090 1523090 1445462 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51782338 COSM96398 99379966 c.2585T>A p.L862Q Substitution - Missense het 38 7:55191834-55191834 + - PATHOGENIC .98046 Variant of unknown origin 21284055 surgery-fixed NS ENSP00000275493.2:p.Leu862Gln ENST00000275493.6:c.2585T>A 7:g.55191834T>A EGFR ENST00000275493.6 3633 3236 TCGA-95-7947-01 1914103 1802385 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51819886 COSM6178068 99384393 c.271A>G p.I91V Substitution - Missense 38 7:55143335-55143335 + - PATHOGENIC .98845 Variant of unknown origin 417 fresh/frozen - NOS primary 67 ENSP00000275493.2:p.Ile91Val ENST00000275493.6:c.271A>G 7:g.55143335A>G EGFR ENST00000275493.6 3633 3236 1593030 1593030 1513956 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51776171 COSM28605 99430754 c.2611G>A p.A871T Substitution - Missense 38 7:55191860-55191860 + - PATHOGENIC .9853 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000275493.2:p.Ala871Thr ENST00000275493.6:c.2611G>A 7:g.55191860G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897801 897801 815423 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51806784 COSM12428 133224142 c.1990_1992delinsCAT p.E664H Substitution - Missense 38 7:55173984-55173986 + - Variant of unknown origin 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Glu664His ENST00000455089.5:c.1990_1992delinsCAT 7:g.55173984_55173986delinsCAT EGFR ENST00000275493.6 3633 3236 Mel-RMU-DR8 1941946 1828866 skin NS NS NS malignant_melanoma NS NS NS n COSM49040 178380912 c.? p.P753S Substitution - Missense + - Variant of unknown origin 22437314 cell-line NS ENSP00000275493.2:p.Pro753Ser EGFR ENST00000275493.6 3633 3236 1592886 1592886 1513812 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51800543 COSM133184 99383227 c.2150T>C p.V717A Substitution - Missense 38 7:55174009-55174009 + - PATHOGENIC .95988 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000275493.2:p.Val717Ala ENST00000275493.6:c.2150T>C 7:g.55174009T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GTL-16 1945868 1832778 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51809237 COSM18445 133206547 c.3008C>T p.A1003V Substitution - Missense 38 7:55201763-55201763 + - NEUTRAL .41771 Variant of unknown origin 18186519 cell-line NS ENSP00000415559.1:p.Ala1003Val ENST00000455089.5:c.3008C>T 7:g.55201763C>T EGFR ENST00000275493.6 3633 3236 1135563 1135563 1048127 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM27536 178380580 c.? p.H773Y Substitution - Missense + - Variant of unknown origin 18676761 NS NS 49 ENSP00000275493.2:p.His773Tyr EGFR ENST00000275493.6 3633 3236 1989972 1989972 1875311 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51765668 COSM13198 99380968 c.2596G>A p.E866K Substitution - Missense het 38 7:55191845-55191845 + - PATHOGENIC .98912 Variant of unknown origin 23585556 surgery-fixed recurrent ENSP00000275493.2:p.Glu866Lys ENST00000275493.6:c.2596G>A 7:g.55191845G>A EGFR ENST00000275493.6 3633 3236 Mel-RMU-DR9 1941947 1828866 skin NS NS NS malignant_melanoma NS NS NS n COSM49040 178380912 c.? p.P753S Substitution - Missense + - Variant of unknown origin 22437314 cell-line NS ENSP00000275493.2:p.Pro753Ser EGFR ENST00000275493.6 3633 3236 2874111 2874111 2728927 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSM9856971 178391759 c.? p.A647T Substitution - Missense + - Variant of unknown origin 32930150 circulating tumour NS 76 ENSP00000275493.2:p.Ala647Thr EGFR ENST00000275493.6 3633 3236 1891992 1891992 1781361 skin NS NS NS malignant_melanoma NS NS NS n COSM1235285 178388032 c.? p.G796S Substitution - Missense + - Variant of unknown origin 23444215 surgery - NOS NS 75 ENSP00000275493.2:p.Gly796Ser EGFR ENST00000275493.6 3633 3236 1661375 1661375 1574990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51788551 COSM214349 99392841 c.2071C>T p.P691S Substitution - Missense 38 7:55173930-55173930 + - PATHOGENIC .98279 Variant of unknown origin 22483783 surgery-fixed NS 82 ENSP00000275493.2:p.Pro691Ser ENST00000275493.6:c.2071C>T 7:g.55173930C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592886 1592886 1513812 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51800543 COSM133184 133211846 c.2015T>C p.V672A Substitution - Missense 38 7:55174009-55174009 + - PATHOGENIC .95988 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000415559.1:p.Val672Ala ENST00000455089.5:c.2015T>C 7:g.55174009T>C EGFR ENST00000275493.6 3633 3236 2345116 2345116 2209788 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2131899 2131899 2005963 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419415 NS NS 51 EGFR ENST00000275493.6 3633 3236 2345039 2345039 2209711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2693325 2693325 2552244 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSM20894 178379162 c.? p.A859T Substitution - Missense + - Variant of unknown origin 28062544 surgery-fixed primary ENSP00000275493.2:p.Ala859Thr EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042854 1042854 959195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766584 COSM12371 133211112 c.1991A>T p.E664V Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97538 Variant of unknown origin 17285735 surgery - NOS NS ENSP00000415559.1:p.Glu664Val ENST00000455089.5:c.1991A>T 7:g.55173985A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166428 1166428 1078742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773237 COSM28609 133238380 c.2281A>G p.K761E Substitution - Missense het 38 7:55181425-55181425 + - PATHOGENIC .9712 Variant of unknown origin 16870303 surgery - NOS NS 67 ENSP00000415559.1:p.Lys761Glu ENST00000455089.5:c.2281A>G 7:g.55181425A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2585427 2585427 2446591 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51767869 COSM3266583 133205938 c.1216C>T p.R406C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 25623215 surgery - NOS recurrent ENSP00000415559.1:p.Arg406Cys ENST00000455089.5:c.1216C>T 7:g.55160191C>T EGFR ENST00000275493.6 3633 3236 1135556 1135556 1048120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM27535 178387131 c.? p.K806E Substitution - Missense + - Variant of unknown origin 18676761 NS NS 77 ENSP00000275493.2:p.Lys806Glu EGFR ENST00000275493.6 3633 3236 907090 907090 824602 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51833668 COSM12675 99429874 c.2575G>A p.A859T Substitution - Missense het 38 7:55191824-55191824 + - PATHOGENIC .98898 Variant of unknown origin 15710947 surgery-fixed NS ENSP00000275493.2:p.Ala859Thr ENST00000275493.6:c.2575G>A 7:g.55191824G>A EGFR ENST00000275493.6 3633 3236 1500143 1500143 1423022 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 21258250 surgery-fixed NS ENSP00000275493.2:p.Glu709Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-J45330 2905663 2759919 NS NS NS NS malignant_melanoma NS NS NS n COSV105864517 COSM9991398 133264846 c.3136G>A p.G1046S Substitution - Missense 38 7:55202625-55202625 + - PATHOGENIC .98023 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Gly1046Ser ENST00000455089.5:c.3136G>A 7:g.55202625G>A EGFR ENST00000275493.6 3633 3236 1135550 1135550 1048114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM27534 178390811 c.? p.R776G Substitution - Missense + - Variant of unknown origin 18676761 NS NS 87 EGFR ENST00000275493.6 3633 3236 1089111 1089111 1004065 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26037 178388590 c.? p.A755D Substitution - Missense + - Variant of unknown origin 17908804 fine needle aspirate primary 53 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 37 2760145 2618678 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51797913 COSM7339051 133212495 c.2370C>A p.H790Q Substitution - Missense 38 7:55191754-55191754 + - PATHOGENIC .83351 Variant of unknown origin 29876005 surgery-fixed NS ENSP00000415559.1:p.His790Gln ENST00000455089.5:c.2370C>A 7:g.55191754C>A EGFR ENST00000275493.6 3633 3236 6 2806405 2663124 penis NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV99292322 COSM6503291 99446408 c.2617G>A p.G873R Substitution - Missense 38 7:55191866-55191866 + - PATHOGENIC .98912 Variant of unknown origin 30446465 surgery-fixed metastasis 72 ENSP00000275493.2:p.Gly873Arg ENST00000275493.6:c.2617G>A 7:g.55191866G>A EGFR ENST00000275493.6 3633 3236 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51841225 COSM1090895 99379567 c.3499C>A p.L1167M Substitution - Missense het 38 7:55205483-55205483 + - PATHOGENIC .76649 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000275493.2:p.Leu1167Met ENST00000275493.6:c.3499C>A 7:g.55205483C>A EGFR ENST00000275493.6 3633 3236 MM1S 1889512 1778952 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV51776216 COSM1235506 99437799 c.2749G>C p.G917R Substitution - Missense 38 7:55198764-55198764 + - PATHOGENIC .9843 Variant of unknown origin 23396385 cell-line NS ENSP00000275493.2:p.Gly917Arg ENST00000275493.6:c.2749G>C 7:g.55198764G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 11 2570179 2431476 skin face NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51775232 COSM5991527 133235419 c.2246C>T p.P749L Substitution - Missense 38 7:55181390-55181390 + - PATHOGENIC .96631 Variant of unknown origin 27311873 surgery-fixed NS 65 ENSP00000415559.1:p.Pro749Leu ENST00000455089.5:c.2246C>T 7:g.55181390C>T EGFR ENST00000275493.6 3633 3236 2226911 2226911 2094646 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51789830 COSM26035 99383994 c.2591C>A p.A864E Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .95798 Variant of unknown origin 24891042 NS NS ENSP00000275493.2:p.Ala864Glu ENST00000275493.6:c.2591C>A 7:g.55191840C>A EGFR ENST00000275493.6 3633 3236 2345040 2345040 2209712 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2345033 2345033 2209705 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2096207 2096207 1974271 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 914815 914815 832264 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 99380328 c.2612C>G p.A871G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 15738541 surgery fresh/frozen recurrent ENSP00000275493.2:p.Ala871Gly ENST00000275493.6:c.2612C>G 7:g.55191861C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2687132 2687132 2546114 breast NS NS NS carcinoma NS NS NS n COSV51783638 COSM28514 133236788 c.2360G>T p.R787L Substitution - Missense 38 7:55191744-55191744 + - PATHOGENIC .96073 Variant of unknown origin 27284958 surgery-fixed metastasis 67 ENSP00000415559.1:p.Arg787Leu ENST00000455089.5:c.2360G>T 7:g.55191744G>T EGFR ENST00000275493.6 3633 3236 2029027 2029027 1910909 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM30753 178379234 c.? p.E709V Substitution - Missense het + - Variant of unknown origin 23628817 NS NS ENSP00000275493.2:p.Glu709Val EGFR ENST00000275493.6 3633 3236 UVDUD0 2762706 2620965 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51767906 COSM7340119 99443494 c.433C>A p.H145N Substitution - Missense 38 7:55146614-55146614 + - NEUTRAL .01483 Variant of unknown origin 29615459 NS primary 63 ENSP00000275493.2:p.His145Asn ENST00000275493.6:c.433C>A 7:g.55146614C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166428 1166428 1078742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773249 COSM28610 133238386 c.2306T>C p.L769P Substitution - Missense het 38 7:55181450-55181450 + - PATHOGENIC .94523 Variant of unknown origin 16870303 surgery - NOS NS 67 ENSP00000415559.1:p.Leu769Pro ENST00000455089.5:c.2306T>C 7:g.55181450T>C EGFR ENST00000275493.6 3633 3236 1623715 1623715 1541302 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 21615826 surgery-fixed primary EGFR ENST00000275493.6 3633 3236 2344992 2344992 2209664 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2345005 2345005 2209677 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 LUAD-NYU184 1765199 1669519 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51830659 COSM370916 99409945 c.2570G>T p.G857V Substitution - Missense 38 7:55191819-55191819 + - PATHOGENIC .99007 Variant of unknown origin 22980975 surgery - NOS primary 77 ENSP00000275493.2:p.Gly857Val ENST00000275493.6:c.2570G>T 7:g.55191819G>T EGFR ENST00000275493.6 3633 3236 1592878 1592878 1513804 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51811057 COSM133182 99399478 c.2098A>G p.N700D Substitution - Missense 38 7:55173957-55173957 + - PATHOGENIC .98114 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000275493.2:p.Asn700Asp ENST00000275493.6:c.2098A>G 7:g.55173957A>G EGFR ENST00000275493.6 3633 3236 2816316 2816316 2672668 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSM9225783 178387023 c.? p.A882T Substitution - Missense + - Variant of unknown origin 31628675 surgery-fixed NS ENSP00000275493.2:p.Ala882Thr EGFR ENST00000275493.6 3633 3236 1179044 1179044 1091006 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51805944 COSM28931 99449706 c.2533G>A p.V845M Substitution - Missense hom 38 7:55191782-55191782 + - PATHOGENIC .98912 Variant of unknown origin 19190079 surgery-fixed primary 35 ENSP00000275493.2:p.Val845Met ENST00000275493.6:c.2533G>A 7:g.55191782G>A EGFR ENST00000275493.6 3633 3236 2637591 2637591 2497964 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51826065 COSM6438146 99413249 c.2091A>T p.E697D Substitution - Missense 38 7:55173950-55173950 + - PATHOGENIC .86906 Variant of unknown origin 27105513 surgery-fixed NS ENSP00000275493.2:p.Glu697Asp ENST00000275493.6:c.2091A>T 7:g.55173950A>T EGFR ENST00000275493.6 3633 3236 2733535 2733535 2592288 lung right NS NS carcinoma adenocarcinoma NS NS n COSM7002299 178381641 c.? p.P794L Substitution - Missense + Yes Variant of unknown origin 29704676 circulating tumour recurrent 36 ENSP00000275493.2:p.Pro794Leu EGFR ENST00000275493.6 3633 3236 1881362 1881362 1771513 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1235341 178387389 c.? p.H773P Substitution - Missense + - Variant of unknown origin 23362162 surgery-fixed NS ENSP00000275493.2:p.His773Pro EGFR ENST00000275493.6 3633 3236 NKI_LPSCC_59 2810565 2667226 upper_aerodigestive_tract pharynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV99296441 COSM9178873 99410228 c.3043G>A p.E1015K Substitution - Missense 38 7:55201284-55201284 + - PATHOGENIC .99529 Variant of unknown origin 29884412 surgery fresh/frozen primary ENSP00000275493.2:p.Glu1015Lys ENST00000275493.6:c.3043G>A 7:g.55201284G>A EGFR ENST00000275493.6 3633 3236 2584874 2584874 2446038 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSM6009000 178378913 c.? p.G465R Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Gly465Arg EGFR ENST00000275493.6 3633 3236 1964335 1964335 1850870 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1651578 178380642 c.? p.K714N Substitution - Missense + - Variant of unknown origin 23749122 NS NS ENSP00000275493.2:p.Lys714Asn EGFR ENST00000275493.6 3633 3236 1471804 1471804 1395542 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51784727 COSM53227 99414142 c.2506C>A p.R836S Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .95567 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000275493.2:p.Arg836Ser ENST00000275493.6:c.2506C>A 7:g.55191755C>A EGFR ENST00000275493.6 3633 3236 6 2806405 2663124 penis NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV99292321 COSM9115440 99446401 c.2612C>A p.A871E Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98397 Variant of unknown origin 30446465 surgery-fixed metastasis 72 ENSP00000275493.2:p.Ala871Glu ENST00000275493.6:c.2612C>A 7:g.55191861C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732914 2732914 2591667 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827181 COSM7002280 133252630 c.439C>G p.P147A Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .86378 Variant of unknown origin 28855349 surgery - NOS primary 58 ENSP00000415559.1:p.Pro147Ala ENST00000455089.5:c.439C>G 7:g.55151308C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-M28272 2905583 2759839 urinary_tract NS NS NS carcinoma transitional_cell_carcinoma NS NS n COSV105864105 COSM9996772 133236389 c.1922G>A p.R641K Substitution - Missense 38 7:55173120-55173120 + - PATHOGENIC .99376 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Arg641Lys ENST00000455089.5:c.1922G>A 7:g.55173120G>A EGFR ENST00000275493.6 3633 3236 1053130 1053130 969201 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM24428 178380592 c.? p.H870R Substitution - Missense + - Variant of unknown origin 17409961 surgery - NOS NS 70 ENSP00000275493.2:p.His870Arg EGFR ENST00000275493.6 3633 3236 2603185 2603185 2464076 NS NS NS NS carcinoma adenocarcinoma of_unknown_primary NS n COSM1169666 178380438 c.? p.P596L Substitution - Missense + - Variant of unknown origin 26182302 surgery-fixed metastasis ENSP00000275493.2:p.Pro596Leu EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1989972 1989972 1875311 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51765668 COSM13198 133209210 c.2461G>A p.E821K Substitution - Missense het 38 7:55191845-55191845 + - PATHOGENIC .98912 Variant of unknown origin 23585556 surgery-fixed recurrent ENSP00000415559.1:p.Glu821Lys ENST00000455089.5:c.2461G>A 7:g.55191845G>A EGFR ENST00000275493.6 3633 3236 1500173 1500173 1423052 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM86999 178381421 c.? p.S784F Substitution - Missense + - Variant of unknown origin 21258250 surgery-fixed NS ENSP00000275493.2:p.Ser784Phe EGFR ENST00000275493.6 3633 3236 MYL-063 2672909 2532428 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS n COSM6848494 178380343 c.? p.V674F Substitution - Missense + - Variant of unknown origin 28492226 circulating tumour NS ENSP00000275493.2:p.Val674Phe EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DM10 2466851 2329682 skin face NS NS malignant_melanoma desmoplastic NS NS n COSV51850876 COSM5608334 133219243 c.1222C>T p.L408F Substitution - Missense 38 7:55160197-55160197 + - PATHOGENIC .96542 Variant of unknown origin 26343386 surgery-fixed NS 70 ENSP00000415559.1:p.Leu408Phe ENST00000455089.5:c.1222C>T 7:g.55160197C>T EGFR ENST00000275493.6 3633 3236 2862198 2862198 2717394 lung NS NS NS other hyperplasia NS NS n COSM21603 178379091 c.? p.R776H Substitution - Missense + - Variant of unknown origin 25969368 surgery-fixed primary ENSP00000275493.2:p.Arg776His EGFR ENST00000275493.6 3633 3236 KYSE510 2395007 2257838 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51828940 COSM3266631 99380581 c.2105C>A p.A702D Substitution - Missense 38 7:55173964-55173964 + - PATHOGENIC .97734 Variant of unknown origin 24686850 cell-line NS ENSP00000275493.2:p.Ala702Asp ENST00000275493.6:c.2105C>A 7:g.55173964C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 946830 946830 863353 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51866933 COSM14071 133275893 c.2554G>A p.V852I Substitution - Missense 38 7:55192829-55192829 + - PATHOGENIC .96332 Variant of unknown origin 16204011 surgery-fixed NS ENSP00000415559.1:p.Val852Ile ENST00000455089.5:c.2554G>A 7:g.55192829G>A EGFR ENST00000275493.6 3633 3236 1734097 1734097 1640046 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 22842370 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2345852 2345852 2210524 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25281710 NS NS EGFR ENST00000275493.6 3633 3236 1914969 1914969 1802971 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 23590575 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2584902 2584902 2446066 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSM6009003 178384840 c.? p.S492R Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Ser492Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166428 1166428 1078742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773222 COSM28608 133238376 c.2258T>A p.L753H Substitution - Missense het 38 7:55181402-55181402 + - PATHOGENIC .95568 Variant of unknown origin 16870303 surgery - NOS NS 67 ENSP00000415559.1:p.Leu753His ENST00000455089.5:c.2258T>A 7:g.55181402T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879231 1879231 1769786 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51800685 COSM1235323 133265266 c.2257C>G p.L753V Substitution - Missense 38 7:55181401-55181401 + - PATHOGENIC .96187 Variant of unknown origin 23468066 fine needle aspirate NS 73 ENSP00000415559.1:p.Leu753Val ENST00000455089.5:c.2257C>G 7:g.55181401C>G EGFR ENST00000275493.6 3633 3236 1162177 1162177 1074509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51818033 COSM28508 99400420 c.2104G>T p.A702S Substitution - Missense 38 7:55173963-55173963 + - PATHOGENIC .97325 Variant of unknown origin 19020901 NS NS ENSP00000275493.2:p.Ala702Ser ENST00000275493.6:c.2104G>T 7:g.55173963G>T EGFR ENST00000275493.6 3633 3236 OX-CO-2_R2_Cetux 2841377 2696927 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576981 COSM9396333 99441637 c.1473A>G p.I491M Substitution - Missense 38 7:55160313-55160313 + - NEUTRAL .12443 Variant of unknown origin 25623215 cell-line NS ENSP00000275493.2:p.Ile491Met ENST00000275493.6:c.1473A>G 7:g.55160313A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2 2557184 2418609 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51828150 COSM5976431 133207346 c.1420G>A p.E474K Substitution - Missense 38 7:55161555-55161555 + - PATHOGENIC .8557 Variant of unknown origin 26934577 surgery fresh/frozen NS ENSP00000415559.1:p.Glu474Lys ENST00000455089.5:c.1420G>A 7:g.55161555G>A EGFR ENST00000275493.6 3633 3236 TCGA-60-2708-01 1782119 1686118 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51807273 COSM747426 99394576 c.2159C>G p.S720C Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .97998 Variant of unknown origin 418 fresh/frozen - NOS primary 64 ENSP00000275493.2:p.Ser720Cys ENST00000275493.6:c.2159C>G 7:g.55174018C>G EGFR ENST00000275493.6 3633 3236 UM-SCC-17B 2296307 2161910 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825836 COSM4599146 99404127 c.345T>A p.N115K Substitution - Missense 38 7:55143409-55143409 + - NEUTRAL .2671 Variant of unknown origin 25275298 cell-line NS 47 ENSP00000275493.2:p.Asn115Lys ENST00000275493.6:c.345T>A 7:g.55143409T>A EGFR ENST00000275493.6 3633 3236 5-GE016-T1 2869741 2724738 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110479 COSM9796964 99451652 c.3329A>T p.Y1110F Substitution - Missense 38 7:55205313-55205313 + - PATHOGENIC .97664 Variant of unknown origin 26950094 surgery - NOS NS 77 ENSP00000275493.2:p.Tyr1110Phe ENST00000275493.6:c.3329A>T 7:g.55205313A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DM51 2466875 2329706 skin neck NS NS malignant_melanoma desmoplastic NS NS n COSV51774157 COSM5608355 133251577 c.1671A>T p.E557D Substitution - Missense 38 7:55165363-55165363 + - PATHOGENIC .71202 Variant of unknown origin 26343386 surgery-fixed NS 88 ENSP00000415559.1:p.Glu557Asp ENST00000455089.5:c.1671A>T 7:g.55165363A>T EGFR ENST00000275493.6 3633 3236 2584896 2584896 2446060 large_intestine colon right NS carcinoma adenocarcinoma NS NS n COSM6009003 178384840 c.? p.S492R Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Ser492Arg EGFR ENST00000275493.6 3633 3236 1587200 1587200 1508371 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM24428 178380592 c.? p.H870R Substitution - Missense + - Variant of unknown origin 21841502 surgery-fixed NS 56 ENSP00000275493.2:p.His870Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1974004 1974004 1860246 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51800018 COSM1651735 133244659 c.2420A>G p.K807R Substitution - Missense 38 7:55191804-55191804 + - PATHOGENIC .97982 Variant of unknown origin 23584298 surgery - NOS NS ENSP00000415559.1:p.Lys807Arg ENST00000455089.5:c.2420A>G 7:g.55191804A>G EGFR ENST00000275493.6 3633 3236 2226912 2226912 2094647 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51790813 COSM4170225 99437904 c.2597A>T p.E866V Substitution - Missense 38 7:55191846-55191846 + - PATHOGENIC .98607 Variant of unknown origin 24891042 NS NS ENSP00000275493.2:p.Glu866Val ENST00000275493.6:c.2597A>T 7:g.55191846A>T EGFR ENST00000275493.6 3633 3236 1036634 1036634 953391 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM22421 178390554 c.? p.Q812R Substitution - Missense + - Variant of unknown origin 17201173 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 133232898 c.1027G>A p.D343N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000415559.1:p.Asp343Asn ENST00000455089.5:c.1027G>A 7:g.55156787G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD42091a 2894825 2749313 skin extremity NS NS malignant_melanoma superficial_spreading NS NS y COSV105110459 COSM9878542 133281573 c.2771C>T p.S924F Substitution - Missense 38 7:55200373-55200373 + - PATHOGENIC .97308 Variant of unknown origin 33024263 surgery-fixed metastasis 57 ENSP00000415559.1:p.Ser924Phe ENST00000455089.5:c.2771C>T 7:g.55200373C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2290053 2290053 2156118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51804114 COSM4424126 133259417 c.1970C>T p.A657V Substitution - Missense het 38 7:55173964-55173964 + - PATHOGENIC .97446 Variant of unknown origin 16740761 surgery - NOS NS 50 ENSP00000415559.1:p.Ala657Val ENST00000455089.5:c.1970C>T 7:g.55173964C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1047800 1047800 964029 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51774943 COSM23611 133242074 c.2318G>A p.C773Y Substitution - Missense 38 7:55181462-55181462 + - PATHOGENIC .97439 Variant of unknown origin 17354229 surgery-fixed NS 60 ENSP00000415559.1:p.Cys773Tyr ENST00000455089.5:c.2318G>A 7:g.55181462G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105111181 COSM9542450 99406489 c.61G>A p.A21T Substitution - Missense 38 7:55019338-55019338 + - NEUTRAL .06121 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000275493.2:p.Ala21Thr ENST00000275493.6:c.61G>A 7:g.55019338G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-95-7947-01 1914103 1802385 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51819914 COSM6178048 133212977 c.3020G>T p.R1007I Substitution - Missense 38 7:55201775-55201775 + - PATHOGENIC .971 Variant of unknown origin 417 fresh/frozen - NOS primary 67 ENSP00000415559.1:p.Arg1007Ile ENST00000455089.5:c.3020G>T 7:g.55201775G>T EGFR ENST00000275493.6 3633 3236 1658048 1658048 1572501 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM211764 178383848 c.? p.L703V Substitution - Missense + - Variant of unknown origin 22458769 surgery-fixed primary ENSP00000275493.2:p.Leu703Val EGFR ENST00000275493.6 3633 3236 1729748 1729748 1635719 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM255173 178391087 c.? p.C775R Substitution - Missense + - Variant of unknown origin 22805266 NS NS EGFR ENST00000275493.6 3633 3236 1964335 1964335 1850870 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 23749122 NS NS ENSP00000275493.2:p.Glu709Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1790529 1790529 1693508 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51771443 COSM12727 133206095 c.2416G>A p.V806I Substitution - Missense 38 7:55191800-55191800 + - PATHOGENIC .98898 Variant of unknown origin 16152581 fixed - NOS NS ENSP00000415559.1:p.Val806Ile ENST00000455089.5:c.2416G>A 7:g.55191800G>A EGFR ENST00000275493.6 3633 3236 TCGA-95-7039-01 1914100 1802382 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51829394 COSM28515 99439231 c.2763C>A p.S921R Substitution - Missense 38 7:55198778-55198778 + - .69453 Variant of unknown origin 417 fresh/frozen - NOS primary 54 ENSP00000275493.2:p.Ser921Arg ENST00000275493.6:c.2763C>A 7:g.55198778C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-N27113 2905421 2759677 gastrointestinal_tract_(site_indeterminate) NS NS NS carcinoma NS NS NS n COSV105864561 COSM9997503 133269984 c.3115G>A p.D1039N Substitution - Missense 38 7:55202604-55202604 + - PATHOGENIC .96545 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000415559.1:p.Asp1039Asn ENST00000455089.5:c.3115G>A 7:g.55202604G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 99406505 c.1162G>A p.D388N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000275493.2:p.Asp388Asn ENST00000275493.6:c.1162G>A 7:g.55156787G>A EGFR ENST00000275493.6 3633 3236 2345124 2345124 2209796 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 BL-18-K10011 2905035 2759291 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864163 COSM10000367 99415967 c.407C>A p.P136H Substitution - Missense 38 7:55143471-55143471 + - PATHOGENIC .91703 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000275493.2:p.Pro136His ENST00000275493.6:c.407C>A 7:g.55143471C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592874 1592874 1513800 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51790353 COSM13178 133274216 c.1946C>T p.P649L Substitution - Missense 38 7:55173940-55173940 + - PATHOGENIC .97388 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000415559.1:p.Pro649Leu ENST00000455089.5:c.1946C>T 7:g.55173940C>T EGFR ENST00000275493.6 3633 3236 2344987 2344987 2209659 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2131897 2131897 2005961 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419415 NS NS 70 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1179044 1179044 1091006 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51805944 COSM28931 133272811 c.2398G>A p.V800M Substitution - Missense hom 38 7:55191782-55191782 + - PATHOGENIC .98912 Variant of unknown origin 19190079 surgery-fixed primary 35 ENSP00000415559.1:p.Val800Met ENST00000455089.5:c.2398G>A 7:g.55191782G>A EGFR ENST00000275493.6 3633 3236 1489065 1489065 1412385 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51778677 COSM85994 99453046 c.2576C>A p.A859D Substitution - Missense het 38 7:55191825-55191825 + - PATHOGENIC .98386 Variant of unknown origin 21317745 surgery-fixed NS 59 ENSP00000275493.2:p.Ala859Asp ENST00000275493.6:c.2576C>A 7:g.55191825C>A EGFR ENST00000275493.6 3633 3236 2029031 2029031 1910913 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM26411 178380422 c.? p.S720F Substitution - Missense het + - Variant of unknown origin 23628817 NS NS ENSP00000275493.2:p.Ser720Phe EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471804 1471804 1395542 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51784727 COSM53227 133240277 c.2371C>A p.R791S Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .95567 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000415559.1:p.Arg791Ser ENST00000455089.5:c.2371C>A 7:g.55191755C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DM8 2466885 2329716 skin scalp NS NS malignant_melanoma desmoplastic NS NS n COSV51853062 COSM5611261 133211530 c.3002_3003delinsTT p.T1001I Substitution - Missense 38 7:55201757-55201758 + - Variant of unknown origin 26343386 surgery-fixed NS 81 ENSP00000415559.1:p.Thr1001Ile ENST00000455089.5:c.3002_3003delinsTT 7:g.55201757_55201758delinsTT EGFR ENST00000275493.6 3633 3236 2262692 2262692 2129676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM4386712 178383537 c.? p.R803Q Substitution - Missense + - Variant of unknown origin 25146938 surgery-fixed NS 66 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-05-5425-01 1780080 1684079 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51798380 COSM6178051 133266354 c.2433T>G p.F811L Substitution - Missense 38 7:55191817-55191817 + - NEUTRAL .41266 Variant of unknown origin 417 fresh/frozen - NOS primary 68 ENSP00000415559.1:p.Phe811Leu ENST00000455089.5:c.2433T>G 7:g.55191817T>G EGFR ENST00000275493.6 3633 3236 1668463 1668463 1581756 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51787416 COSM219794 99382078 c.2499G>T p.L833F Substitution - Missense 38 7:55191748-55191748 + - PATHOGENIC .95793 Variant of unknown origin 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu833Phe ENST00000275493.6:c.2499G>T 7:g.55191748G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-18-T42044 2905562 2759818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864537 COSM10001654 133267432 c.3109A>T p.I1037L Substitution - Missense 38 7:55202598-55202598 + - NEUTRAL .15191 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Ile1037Leu ENST00000455089.5:c.3109A>T 7:g.55202598A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594587 1594587 1515555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772325 COSM133628 133276799 c.2218A>C p.T740P Substitution - Missense 38 7:55181362-55181362 + - PATHOGENIC .91002 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000415559.1:p.Thr740Pro ENST00000455089.5:c.2218A>C 7:g.55181362A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 6 2806405 2663124 penis NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV99292321 COSM9115440 133269811 c.2477C>A p.A826E Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98397 Variant of unknown origin 30446465 surgery-fixed metastasis 72 ENSP00000415559.1:p.Ala826Glu ENST00000455089.5:c.2477C>A 7:g.55191861C>A EGFR ENST00000275493.6 3633 3236 2862229 2862229 2717419 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM21603 178379091 c.? p.R776H Substitution - Missense + - Variant of unknown origin 25969368 surgery-fixed primary ENSP00000275493.2:p.Arg776His EGFR ENST00000275493.6 3633 3236 1487186 1487186 1410796 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 21317742 surgery-fixed NS ENSP00000275493.2:p.Glu709Ala EGFR ENST00000275493.6 3633 3236 1661391 1661391 1575006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51845318 COSM214350 99380112 c.2602G>A p.E868K Substitution - Missense het 38 7:55191851-55191851 + - PATHOGENIC .98896 Variant of unknown origin 22483783 surgery-fixed NS 49 ENSP00000275493.2:p.Glu868Lys ENST00000275493.6:c.2602G>A 7:g.55191851G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-70-6722-01 1783058 1687057 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51807303 COSM747424 133204228 c.2392G>T p.V798L Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .9903 Variant of unknown origin 418 fresh/frozen - NOS primary 47 ENSP00000415559.1:p.Val798Leu ENST00000455089.5:c.2392G>T 7:g.55191776G>T EGFR ENST00000275493.6 3633 3236 2585242 2585242 2446406 large_intestine colon right NS carcinoma adenocarcinoma NS NS n COSM6009001 178378911 c.? p.S464L Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Ser464Leu EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2817999 2817999 2674298 lung right NS NS carcinoma adenocarcinoma NS NS n COSV104368882 COSM9263867 133249085 c.2224C>A p.Q742K Substitution - Missense 38 7:55181368-55181368 + - PATHOGENIC .97684 Variant of unknown origin 31422893 pleural effusion metastasis 72 ENSP00000415559.1:p.Gln742Lys ENST00000455089.5:c.2224C>A 7:g.55181368C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 G45 1179740 1091702 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51815137 COSM28943 133244968 c.2162T>C p.M721T Substitution - Missense 38 7:55181306-55181306 + - PATHOGENIC .97686 Variant of unknown origin 19096301 surgery fresh/frozen primary 61 ENSP00000415559.1:p.Met721Thr ENST00000455089.5:c.2162T>C 7:g.55181306T>C EGFR ENST00000275493.6 3633 3236 TCGA-05-5425-01 1780080 1684079 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51798380 COSM6178051 99443018 c.2568T>G p.F856L Substitution - Missense 38 7:55191817-55191817 + - NEUTRAL .41266 Variant of unknown origin 417 fresh/frozen - NOS primary 68 ENSP00000275493.2:p.Phe856Leu ENST00000275493.6:c.2568T>G 7:g.55191817T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 ESO-721 1890961 1780330 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV51788608 COSM1251016 133220202 c.1205C>A p.S402Y Substitution - Missense 38 7:55160180-55160180 + - .5293 Variant of unknown origin 23525077 surgery fresh/frozen primary 68 ENSP00000415559.1:p.Ser402Tyr ENST00000455089.5:c.1205C>A 7:g.55160180C>A EGFR ENST00000275493.6 3633 3236 1696880 1696880 1605008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26411 178380422 c.? p.S720F Substitution - Missense + - Variant of unknown origin 22674612 surgery-fixed NS ENSP00000275493.2:p.Ser720Phe EGFR_ENST00000455089 ENST00000455089.5 3276 3236 3584 915990 833389 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51863898 COSM13196 133285248 c.2423T>C p.I808T Substitution - Missense 38 7:55191807-55191807 + - PATHOGENIC .97798 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000415559.1:p.Ile808Thr ENST00000455089.5:c.2423T>C 7:g.55191807T>C EGFR ENST00000275493.6 3633 3236 2862863 2862863 2718025 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51852379 COSM22942 99398784 c.2335G>T p.G779C Substitution - Missense 38 7:55181344-55181344 + - PATHOGENIC .98402 Variant of unknown origin 29489023 surgery - NOS NS ENSP00000275493.2:p.Gly779Cys ENST00000275493.6:c.2335G>T 7:g.55181344G>T EGFR ENST00000275493.6 3633 3236 2481845 2481845 2344590 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM24428 178380592 c.? p.H870R Substitution - Missense + - Variant of unknown origin 26463840 surgery fresh/frozen NS ENSP00000275493.2:p.His870Arg EGFR ENST00000275493.6 3633 3236 2579304 2579304 2440641 NS NS NS NS malignant_melanoma NS NS NS n COSV51820036 COSM6005738 99419363 c.2423A>G p.N808S Substitution - Missense 38 7:55181432-55181432 + - PATHOGENIC .8643 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000275493.2:p.Asn808Ser ENST00000275493.6:c.2423A>G 7:g.55181432A>G EGFR ENST00000275493.6 3633 3236 1664601 1664601 1578051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21602 178380317 c.? p.L833V Substitution - Missense + - Variant of unknown origin 21899495 pericardial fluid NS 52 ENSP00000275493.2:p.Leu833Val EGFR ENST00000275493.6 3633 3236 2822297 2822297 2678157 urinary_tract NS NS NS carcinoma transitional_cell_carcinoma NS NS n COSM1235366 178384307 c.? p.G724S Substitution - Missense + - Variant of unknown origin 26373574 fixed - NOS NS ENSP00000275493.2:p.Gly724Ser EGFR ENST00000275493.6 3633 3236 1964291 1964291 1850826 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1651574 178382913 c.? p.V742I Substitution - Missense + - Variant of unknown origin 23749122 NS NS ENSP00000275493.2:p.Val742Ile EGFR ENST00000275493.6 3633 3236 1162179 1162179 1074511 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51785698 COSM28510 99426140 c.2162G>C p.G721A Substitution - Missense 38 7:55174021-55174021 + - PATHOGENIC .98515 Variant of unknown origin 19020901 NS NS ENSP00000275493.2:p.Gly721Ala ENST00000275493.6:c.2162G>C 7:g.55174021G>C EGFR ENST00000275493.6 3633 3236 1284738 1284738 1196033 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM34157 178387563 c.? p.E866K Substitution - Missense + - Variant of unknown origin 16467085 surgery - NOS NS ENSP00000275493.2:p.Glu866Lys EGFR ENST00000275493.6 3633 3236 2675417 2675417 2534691 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 29100434 surgery - NOS NS ENSP00000275493.2:p.Glu709Ala EGFR ENST00000275493.6 3633 3236 899355 899355 816967 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766584 COSM12371 99382498 c.2126A>T p.E709V Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97538 Variant of unknown origin 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Glu709Val ENST00000275493.6:c.2126A>T 7:g.55173985A>T EGFR ENST00000275493.6 3633 3236 1166448 1166448 1078762 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51776171 COSM28605 99430754 c.2611G>A p.A871T Substitution - Missense het 38 7:55191860-55191860 + - PATHOGENIC .9853 Variant of unknown origin 16870303 surgery - NOS NS 33 ENSP00000275493.2:p.Ala871Thr ENST00000275493.6:c.2611G>A 7:g.55191860G>A EGFR ENST00000275493.6 3633 3236 2011150 2011150 1893788 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM26413 178382100 c.? p.V851I Substitution - Missense + - Variant of unknown origin 24002608 surgery - NOS NS ENSP00000275493.2:p.Val851Ile EGFR ENST00000275493.6 3633 3236 1996945 1996945 1882154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM27111 178379606 c.? p.A871G Substitution - Missense + - Variant of unknown origin 23912954 fixed - NOS NS 56 ENSP00000275493.2:p.Ala871Gly EGFR ENST00000275493.6 3633 3236 1162178 1162178 1074510 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768381 COSM28509 99380368 c.2123A>T p.K708M Substitution - Missense 38 7:55173982-55173982 + - PATHOGENIC .98216 Variant of unknown origin 19020901 NS NS ENSP00000275493.2:p.Lys708Met ENST00000275493.6:c.2123A>T 7:g.55173982A>T EGFR ENST00000275493.6 3633 3236 2047820 2047820 1928092 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24197981 surgery-fixed metastasis EGFR ENST00000275493.6 3633 3236 2750882 2750882 2609578 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 27086595 surgery-fixed NS 78 EGFR ENST00000275493.6 3633 3236 1139185 1139185 1051749 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51772314 COSM27568 99378866 c.2387G>C p.G796A Substitution - Missense het 38 7:55181396-55181396 + - PATHOGENIC .95257 Variant of unknown origin 17695517 surgery - NOS recurrent 63 ENSP00000275493.2:p.Gly796Ala ENST00000275493.6:c.2387G>C 7:g.55181396G>C EGFR ENST00000275493.6 3633 3236 2625563 2625563 2485975 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 99380328 c.2612C>G p.A871G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 27056568 surgery-fixed NS 51 ENSP00000275493.2:p.Ala871Gly ENST00000275493.6:c.2612C>G 7:g.55191861C>G EGFR ENST00000275493.6 3633 3236 2157023 2157023 2025998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24828666 fixed - NOS NS EGFR ENST00000275493.6 3633 3236 2345032 2345032 2209704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1246734 1246734 1158413 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 19692680 surgery - NOS NS EGFR ENST00000275493.6 3633 3236 2106565 2106565 1984428 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24575772 NS NS EGFR ENST00000275493.6 3633 3236 2344986 2344986 2209658 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2345012 2345012 2209684 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 PGBM27 1630925 1547795 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51858275 COSM506581 99444775 c.2950G>A p.D984N Substitution - Missense 38 7:55201191-55201191 + - PATHOGENIC .99577 Variant of unknown origin 22286061 surgery - NOS NS 9 ENSP00000275493.2:p.Asp984Asn ENST00000275493.6:c.2950G>A 7:g.55201191G>A EGFR ENST00000275493.6 3633 3236 1475465 1475465 1399164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM53309 178391221 c.? p.A871E Substitution - Missense + - Variant of unknown origin 21111508 NS NS ENSP00000275493.2:p.Ala871Glu EGFR ENST00000275493.6 3633 3236 2440095 2440095 2302935 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSM7413287 178391184 c.? p.P848I Substitution - Missense + - Variant of unknown origin 25536104 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2026223 2026223 1908312 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21623 178382931 c.? p.L858W Substitution - Missense + - Variant of unknown origin 24040454 surgery-fixed NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-60-2708-01 1782119 1686118 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51807273 COSM747426 133221351 c.2024C>G p.S675C Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .97998 Variant of unknown origin 418 fresh/frozen - NOS primary 64 ENSP00000415559.1:p.Ser675Cys ENST00000455089.5:c.2024C>G 7:g.55174018C>G EGFR ENST00000275493.6 3633 3236 1517880 1517880 1440258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM88795 178382307 c.? p.K754E Substitution - Missense + - Variant of unknown origin 21572125 fine needle aspirate NS 47 ENSP00000275493.2:p.Lys754Glu EGFR ENST00000275493.6 3633 3236 3638 915980 833379 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51866106 COSM13186 99456062 c.2255C>A p.S752Y Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98815 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000275493.2:p.Ser752Tyr ENST00000275493.6:c.2255C>A 7:g.55174792C>A EGFR ENST00000275493.6 3633 3236 H2172 2776265 2634401 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51778282 COSM3266665 99401207 c.3388A>G p.S1130G Substitution - Missense 38 7:55205372-55205372 + - PATHOGENIC .9316 Variant of unknown origin 29681454 NS NS ENSP00000275493.2:p.Ser1130Gly ENST00000275493.6:c.3388A>G 7:g.55205372A>G EGFR ENST00000275493.6 3633 3236 1996946 1996946 1882155 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1666923 178386938 c.? p.G873Q Substitution - Missense + - Variant of unknown origin 23912954 fixed - NOS NS 82 EGFR ENST00000275493.6 3633 3236 1790529 1790529 1693508 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51771443 COSM12727 99378003 c.2551G>A p.V851I Substitution - Missense 38 7:55191800-55191800 + - PATHOGENIC .98898 Variant of unknown origin 16152581 fixed - NOS NS ENSP00000275493.2:p.Val851Ile ENST00000275493.6:c.2551G>A 7:g.55191800G>A EGFR ENST00000275493.6 3633 3236 1500173 1500173 1423052 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM28619 178383742 c.? p.V786M Substitution - Missense + - Variant of unknown origin 21258250 surgery-fixed NS ENSP00000275493.2:p.Val786Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 4988 915987 833386 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51866608 COSM13193 133265608 c.2342A>G p.N781S Substitution - Missense 38 7:55191726-55191726 + - PATHOGENIC .9015 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000415559.1:p.Asn781Ser ENST00000455089.5:c.2342A>G 7:g.55191726A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914815 914815 832264 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 133208531 c.2477C>G p.A826G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 15738541 surgery fresh/frozen recurrent ENSP00000415559.1:p.Ala826Gly ENST00000455089.5:c.2477C>G 7:g.55191861C>G EGFR ENST00000275493.6 3633 3236 1532693 1532693 1455053 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM22543 178382202 c.? p.A743S Substitution - Missense + - Variant of unknown origin 20925915 surgery-fixed NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBC_6 2907852 2762035 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV105864473 COSM10029109 133263583 c.1225A>G p.K409E Substitution - Missense 38 7:55160200-55160200 + - PATHOGENIC .95086 Variant of unknown origin 33563892 surgery-fixed NS 85 ENSP00000415559.1:p.Lys409Glu ENST00000455089.5:c.1225A>G 7:g.55160200A>G EGFR ENST00000275493.6 3633 3236 1996920 1996920 1882129 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1666921 178390147 c.? p.T710A Substitution - Missense + - Variant of unknown origin 23912954 fixed - NOS NS 63 ENSP00000275493.2:p.Thr710Ala EGFR ENST00000275493.6 3633 3236 2421145 2421145 2284067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25605150 surgery - NOS NS EGFR ENST00000275493.6 3633 3236 2096198 2096198 1974262 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 2096189 2096189 1974253 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-05-5423-01 1780079 1684078 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51787416 COSM219794 133210501 c.2364G>T p.L788F Substitution - Missense 38 7:55191748-55191748 + - PATHOGENIC .95793 Variant of unknown origin 417 fresh/frozen - NOS primary 65 ENSP00000415559.1:p.Leu788Phe ENST00000455089.5:c.2364G>T 7:g.55191748G>T EGFR ENST00000275493.6 3633 3236 1837420 1837420 1731619 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1166939 178381712 c.? p.L747V Substitution - Missense + - Variant of unknown origin 23242437 NS NS 64 EGFR ENST00000275493.6 3633 3236 2862095 2862095 2717297 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51799562 COSM6854575 99404369 c.3041A>G p.D1014G Substitution - Missense 38 7:55201282-55201282 + - PATHOGENIC .9951 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000275493.2:p.Asp1014Gly ENST00000275493.6:c.3041A>G 7:g.55201282A>G EGFR ENST00000275493.6 3633 3236 2525685 2525685 2387874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1651576 178384420 c.? p.S768_V769delinsIL Substitution - Missense + - Variant of unknown origin 27304188 pleural effusion recurrent ENSP00000275493.2:p.Ser768_Val769delinsIleLeu EGFR_ENST00000455089 ENST00000455089.5 3276 3236 UCHRNP3 2682251 2541524 large_intestine NS NS NS other ulcerative_colitis NS NS n COSV51799562 COSM6854575 133230120 c.2906A>G p.D969G Substitution - Missense 38 7:55201282-55201282 + - PATHOGENIC .9951 Variant of unknown origin 28524162 surgery fresh/frozen NS 31 ENSP00000415559.1:p.Asp969Gly ENST00000455089.5:c.2906A>G 7:g.55201282A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MM1S 1889512 1778952 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV51776216 COSM1235506 133260687 c.2614G>C p.G872R Substitution - Missense 38 7:55198764-55198764 + - PATHOGENIC .9843 Variant of unknown origin 23396385 cell-line NS ENSP00000415559.1:p.Gly872Arg ENST00000455089.5:c.2614G>C 7:g.55198764G>C EGFR ENST00000275493.6 3633 3236 2595769 2595769 2456645 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM133708 178380057 c.? p.V774M Substitution - Missense + - Variant of unknown origin 27538584 surgery-fixed NS ENSP00000275493.2:p.Val774Met EGFR ENST00000275493.6 3633 3236 2083089 2083089 1961510 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21602 178380317 c.? p.L833V Substitution - Missense + - Variant of unknown origin 24300726 surgery-fixed NS ENSP00000275493.2:p.Leu833Val EGFR ENST00000275493.6 3633 3236 MG-273-tumor 2819121 2675420 meninges NS NS NS meningioma anaplastic NS NS n COSV104369217 COSM9267459 99412834 c.1414G>A p.A472T Substitution - Missense 38 7:55160254-55160254 + - PATHOGENIC .94147 Variant of unknown origin 28713588 surgery - NOS NS ENSP00000275493.2:p.Ala472Thr ENST00000275493.6:c.1414G>A 7:g.55160254G>A EGFR ENST00000275493.6 3633 3236 2585242 2585242 2446406 large_intestine colon right NS carcinoma adenocarcinoma NS NS n COSM6009000 178378913 c.? p.G465R Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Gly465Arg EGFR ENST00000275493.6 3633 3236 2096278 2096278 1974342 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 1734096 1734096 1640045 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 22842370 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2029035 2029035 1910917 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18058 178384438 c.? p.R803L Substitution - Missense het + - Variant of unknown origin 23628817 NS NS EGFR ENST00000275493.6 3633 3236 1024775 1024775 941752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21603 178379091 c.? p.R776H Substitution - Missense het + - Variant of unknown origin 17020982 surgery fresh/frozen recurrent ENSP00000275493.2:p.Arg776His EGFR ENST00000275493.6 3633 3236 2803992 2803992 2660720 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM9114764 178391150 c.? p.M766Q Substitution - Missense + Yes Variant of unknown origin 31254668 circulating tumour recurrent 79 EGFR ENST00000275493.6 3633 3236 LUAD-RT-S01813 1765244 1669564 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51848768 COSM383489 99430085 c.3385C>T p.H1129Y Substitution - Missense 38 7:55205369-55205369 + - PATHOGENIC .72456 Variant of unknown origin 22980975 surgery - NOS primary ENSP00000275493.2:p.His1129Tyr ENST00000275493.6:c.3385C>T 7:g.55205369C>T EGFR ENST00000275493.6 3633 3236 1113001 1113001 1026509 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51780009 COSM27042 99394687 c.2282A>G p.D761G Substitution - Missense 38 7:55174819-55174819 + - PATHOGENIC .9946 Variant of unknown origin 18302229 surgery - NOS NS 68 ENSP00000275493.2:p.Asp761Gly ENST00000275493.6:c.2282A>G 7:g.55174819A>G EGFR ENST00000275493.6 3633 3236 2610902 2610902 2471733 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM4172522 178386505 c.? p.R255Q Substitution - Missense + - Variant of unknown origin 27022036 fixed - NOS NS 79 ENSP00000275493.2:p.Arg255Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-95-7947-01 1914103 1802385 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51819886 COSM6178068 133212958 c.271A>G p.I91V Substitution - Missense 38 7:55143335-55143335 + - PATHOGENIC .98845 Variant of unknown origin 417 fresh/frozen - NOS primary 67 ENSP00000415559.1:p.Ile91Val ENST00000455089.5:c.271A>G 7:g.55143335A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226911 2226911 2094646 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51789830 COSM26035 133212590 c.2456C>A p.A819E Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .95798 Variant of unknown origin 24891042 NS NS ENSP00000415559.1:p.Ala819Glu ENST00000455089.5:c.2456C>A 7:g.55191840C>A EGFR ENST00000275493.6 3633 3236 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51841184 COSM1090877 99379537 c.1621C>A p.L541I Substitution - Missense het 38 7:55161621-55161621 + - NEUTRAL .01946 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000275493.2:p.Leu541Ile ENST00000275493.6:c.1621C>A 7:g.55161621C>A EGFR ENST00000275493.6 3633 3236 1668676 1668676 1581968 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM26413 178382100 c.? p.V851I Substitution - Missense + - Variant of unknown origin 22523351 fixed - NOS NS ENSP00000275493.2:p.Val851Ile EGFR ENST00000275493.6 3633 3236 912834 912834 830326 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51813062 COSM12764 99374656 c.2569G>A p.G857R Substitution - Missense het 38 7:55191818-55191818 + - PATHOGENIC .98898 Variant of unknown origin 15863375 surgery-fixed primary 75 ENSP00000275493.2:p.Gly857Arg ENST00000275493.6:c.2569G>A 7:g.55191818G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162177 1162177 1074509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51818033 COSM28508 133225609 c.1969G>T p.A657S Substitution - Missense 38 7:55173963-55173963 + - PATHOGENIC .97325 Variant of unknown origin 19020901 NS NS ENSP00000415559.1:p.Ala657Ser ENST00000455089.5:c.1969G>T 7:g.55173963G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593030 1593030 1513956 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51776171 COSM28605 133254151 c.2476G>A p.A826T Substitution - Missense 38 7:55191860-55191860 + - PATHOGENIC .9853 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000415559.1:p.Ala826Thr ENST00000455089.5:c.2476G>A 7:g.55191860G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1974004 1974004 1860246 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51800006 COSM1651734 133244655 c.2269G>A p.V757I Substitution - Missense 38 7:55181413-55181413 + - PATHOGENIC .8748 Variant of unknown origin 23584298 surgery - NOS NS ENSP00000415559.1:p.Val757Ile ENST00000455089.5:c.2269G>A 7:g.55181413G>A EGFR ENST00000275493.6 3633 3236 1230480 1230480 1142294 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM30753 178379234 c.? p.E709V Substitution - Missense + - Variant of unknown origin 19536777 NS NS ENSP00000275493.2:p.Glu709Val EGFR ENST00000275493.6 3633 3236 1113000 1113000 1026509 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51780009 COSM27042 99394687 c.2282A>G p.D761G Substitution - Missense 38 7:55174819-55174819 + - PATHOGENIC .9946 Variant of unknown origin 18302229 surgery - NOS NS 68 ENSP00000275493.2:p.Asp761Gly ENST00000275493.6:c.2282A>G 7:g.55174819A>G EGFR ENST00000275493.6 3633 3236 BL-17-G33297 2905054 2759310 NS NS NS NS malignant_melanoma NS NS NS n COSV105863803 COSM9997894 99455751 c.3086C>T p.T1029M Substitution - Missense 38 7:55201327-55201327 + - PATHOGENIC .96845 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000275493.2:p.Thr1029Met ENST00000275493.6:c.3086C>T 7:g.55201327C>T EGFR ENST00000275493.6 3633 3236 TCGA-B0-5713-01 1779868 1683867 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51801505 COSM485464 99455556 c.2414A>G p.H805R Substitution - Missense hom 38 7:55181423-55181423 + - PATHOGENIC .97392 Variant of unknown origin 416 fresh/frozen - NOS primary 75 ENSP00000275493.2:p.His805Arg ENST00000275493.6:c.2414A>G 7:g.55181423A>G EGFR ENST00000275493.6 3633 3236 2421146 2421146 2284068 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25605150 surgery - NOS NS EGFR ENST00000275493.6 3633 3236 2131898 2131898 2005962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419415 NS NS 62 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 6 2806405 2663124 penis NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV99292322 COSM6503291 133269820 c.2482G>A p.G828R Substitution - Missense 38 7:55191866-55191866 + - PATHOGENIC .98912 Variant of unknown origin 30446465 surgery-fixed metastasis 72 ENSP00000415559.1:p.Gly828Arg ENST00000455089.5:c.2482G>A 7:g.55191866G>A EGFR ENST00000275493.6 3633 3236 2344998 2344998 2209670 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 MYL-023 2672890 2532409 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS n COSM6848489 178390631 c.? p.A859S Substitution - Missense + - Variant of unknown origin 28492226 circulating tumour NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-15-W23729 2905323 2759579 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51801258 COSM13553 133216298 c.2437_2438inv p.L813R Substitution - Missense 38 7:55191821-55191822 + - Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2437_2438inv 7:g.55191821_55191822inv EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-18-K10011 2905035 2759291 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864163 COSM10000367 133241681 c.407C>A p.P136H Substitution - Missense 38 7:55143471-55143471 + - PATHOGENIC .91703 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000415559.1:p.Pro136His ENST00000455089.5:c.407C>A 7:g.55143471C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-18-G05395 2905226 2759482 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864510 COSN32285942 133265045 c.3178T>G p.S1060A Substitution - Missense 38 7:55202667-55202667 + - NEUTRAL .04123 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Ser1060Ala ENST00000455089.5:c.3178T>G 7:g.55202667T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1523090 1523090 1445462 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51782338 COSM96398 133208157 c.2450T>A p.L817Q Substitution - Missense het 38 7:55191834-55191834 + - PATHOGENIC .98046 Variant of unknown origin 21284055 surgery-fixed NS ENSP00000415559.1:p.Leu817Gln ENST00000455089.5:c.2450T>A 7:g.55191834T>A EGFR ENST00000275493.6 3633 3236 1083334 1083334 998499 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM23616 178382710 c.? p.L799R Substitution - Missense + - Variant of unknown origin 17596643 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 RDES 2294586 2160613 bone NS NS NS Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour NS NS NS y COSV51793186 COSM4587483 99429094 c.1798A>G p.M600V Substitution - Missense 38 7:55165355-55165355 + - PATHOGENIC .89999 Variant of unknown origin 25186949 cell-line NS ENSP00000275493.2:p.Met600Val ENST00000275493.6:c.1798A>G 7:g.55165355A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1839252 1839252 1733353 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51828195 COSM13180 133231842 c.2053C>T p.L685F Substitution - Missense 38 7:55174725-55174725 + - PATHOGENIC .96849 Variant of unknown origin 23244191 surgery-fixed primary ENSP00000415559.1:p.Leu685Phe ENST00000455089.5:c.2053C>T 7:g.55174725C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2637591 2637591 2497964 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51826065 COSM6438146 133239535 c.1956A>T p.E652D Substitution - Missense 38 7:55173950-55173950 + - PATHOGENIC .86906 Variant of unknown origin 27105513 surgery-fixed NS ENSP00000415559.1:p.Glu652Asp ENST00000455089.5:c.1956A>T 7:g.55173950A>T EGFR ENST00000275493.6 3633 3236 1471805 1471805 1395543 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51847909 COSM53228 99420456 c.2123A>G p.K708R Substitution - Missense 38 7:55173982-55173982 + - PATHOGENIC .98155 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000275493.2:p.Lys708Arg ENST00000275493.6:c.2123A>G 7:g.55173982A>G EGFR ENST00000275493.6 3633 3236 2297822 2297822 2163423 pancreas NS NS NS carcinoma acinar_carcinoma NS NS n COSM4603655 178382423 c.? p.V765M Substitution - Missense + - Variant of unknown origin 25266736 surgery-fixed NS ENSP00000275493.2:p.Val765Met EGFR ENST00000275493.6 3633 3236 1837417 1837417 1731616 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 23242437 NS NS 55 ENSP00000275493.2:p.Glu709Ala EGFR ENST00000275493.6 3633 3236 946820 946820 863343 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773889 COSM14069 99414148 c.2348C>T p.T783I Substitution - Missense 38 7:55181357-55181357 + - PATHOGENIC .96109 Variant of unknown origin 16204011 surgery-fixed NS ENSP00000275493.2:p.Thr783Ile ENST00000275493.6:c.2348C>T 7:g.55181357C>T EGFR ENST00000275493.6 3633 3236 1166417 1166417 1078731 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51815916 COSM28600 99393685 c.2095C>T p.P699S Substitution - Missense het 38 7:55173954-55173954 + - PATHOGENIC .97389 Variant of unknown origin 16870303 surgery - NOS NS 75 ENSP00000275493.2:p.Pro699Ser ENST00000275493.6:c.2095C>T 7:g.55173954C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226912 2226912 2094647 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51790813 COSM4170225 133260803 c.2462A>T p.E821V Substitution - Missense 38 7:55191846-55191846 + - PATHOGENIC .98607 Variant of unknown origin 24891042 NS NS ENSP00000415559.1:p.Glu821Val ENST00000455089.5:c.2462A>T 7:g.55191846A>T EGFR ENST00000275493.6 3633 3236 2803992 2803992 2660720 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM9114763 178391149 c.? p.S306L Substitution - Missense + - Variant of unknown origin 31254668 circulating tumour recurrent 79 ENSP00000275493.2:p.Ser306Leu EGFR ENST00000275493.6 3633 3236 Mel-RMU 1941942 1828866 skin NS NS NS malignant_melanoma NS NS NS n COSM49040 178380912 c.? p.P753S Substitution - Missense + - Variant of unknown origin 22437314 cell-line NS ENSP00000275493.2:p.Pro753Ser EGFR ENST00000275493.6 3633 3236 2422798 2422798 2285720 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM30753 178379234 c.? p.E709V Substitution - Missense + - Variant of unknown origin 25456362 NS NS ENSP00000275493.2:p.Glu709Val EGFR ENST00000275493.6 3633 3236 1113001 1113001 1026509 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51780000 COSM27041 99394677 c.2213T>G p.V738G Substitution - Missense 38 7:55174750-55174750 + - PATHOGENIC .99814 Variant of unknown origin 18302229 surgery - NOS NS 68 ENSP00000275493.2:p.Val738Gly ENST00000275493.6:c.2213T>G 7:g.55174750T>G EGFR ENST00000275493.6 3633 3236 2860650 2860650 2715938 central_nervous_system choroid_plexus NS NS other choroid_plexus_papilloma NS NS n COSV51813062 COSM12764 99374656 c.2569G>A p.G857R Substitution - Missense 38 7:55191818-55191818 + - PATHOGENIC .98898 Variant of unknown origin 31612017 surgery-fixed NS 3 ENSP00000275493.2:p.Gly857Arg ENST00000275493.6:c.2569G>A 7:g.55191818G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592878 1592878 1513804 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51811057 COSM133182 133224577 c.1963A>G p.N655D Substitution - Missense 38 7:55173957-55173957 + - PATHOGENIC .98114 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000415559.1:p.Asn655Asp ENST00000455089.5:c.1963A>G 7:g.55173957A>G EGFR ENST00000275493.6 3633 3236 2345022 2345022 2209694 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2345011 2345011 2209683 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 CC34 2766428 2624647 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV99034450 COSM7342223 99428173 c.2798T>C p.L933P Substitution - Missense 38 7:55198813-55198813 + - PATHOGENIC .98175 Variant of unknown origin 29844865 surgery fresh/frozen NS 69 ENSP00000275493.2:p.Leu933Pro ENST00000275493.6:c.2798T>C 7:g.55198813T>C EGFR ENST00000275493.6 3633 3236 2644152 2644152 2504439 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM6493928 178386597 c.? p.R999C Substitution - Missense + - Variant of unknown origin 28573640 surgery - NOS NS ENSP00000275493.2:p.Arg999Cys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625563 2625563 2485975 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 133208531 c.2477C>G p.A826G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 27056568 surgery-fixed NS 51 ENSP00000415559.1:p.Ala826Gly ENST00000455089.5:c.2477C>G 7:g.55191861C>G EGFR ENST00000275493.6 3633 3236 MKN45 983727 899445 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51809237 COSM18445 99378456 c.3143C>T p.A1048V Substitution - Missense het 38 7:55201763-55201763 + - NEUTRAL .41771 Variant of unknown origin 16596188 cell-line NS ENSP00000275493.2:p.Ala1048Val ENST00000275493.6:c.3143C>T 7:g.55201763C>T EGFR ENST00000275493.6 3633 3236 1996947 1996947 1882156 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21602 178380317 c.? p.L833V Substitution - Missense + - Variant of unknown origin 23912954 fixed - NOS NS 58 ENSP00000275493.2:p.Leu833Val EGFR ENST00000275493.6 3633 3236 1120915 1120915 1034071 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21603 178379091 c.? p.R776H Substitution - Missense + - Variant of unknown origin 18509184 NS NS ENSP00000275493.2:p.Arg776His EGFR ENST00000275493.6 3633 3236 MYL-027_2 2672973 2532464 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS n COSM6848491 178383263 c.? p.E551K Substitution - Missense + - Variant of unknown origin 28492226 circulating tumour recurrent 54 EGFR ENST00000275493.6 3633 3236 1094000 1094000 1008702 urinary_tract bladder NS NS carcinoma NS NS NS n COSV51833668 COSM12675 99429874 c.2575G>A p.A859T Substitution - Missense 38 7:55191824-55191824 + - PATHOGENIC .98898 Variant of unknown origin 17707060 surgery fresh/frozen NS ENSP00000275493.2:p.Ala859Thr ENST00000275493.6:c.2575G>A 7:g.55191824G>A EGFR ENST00000275493.6 3633 3236 1113000 1113000 1026509 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51780000 COSM27041 99394677 c.2213T>G p.V738G Substitution - Missense 38 7:55174750-55174750 + - PATHOGENIC .99814 Variant of unknown origin 18302229 surgery - NOS NS 68 ENSP00000275493.2:p.Val738Gly ENST00000275493.6:c.2213T>G 7:g.55174750T>G EGFR ENST00000275493.6 3633 3236 1996920 1996920 1882129 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1666920 178390148 c.? p.P694S Substitution - Missense + - Variant of unknown origin 23912954 fixed - NOS NS 63 ENSP00000275493.2:p.Pro694Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 OX-CO-2_R2_Cetux 2841377 2696927 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576981 COSM9396333 133264813 c.1338A>G p.I446M Substitution - Missense 38 7:55160313-55160313 + - NEUTRAL .12443 Variant of unknown origin 25623215 cell-line NS ENSP00000415559.1:p.Ile446Met ENST00000455089.5:c.1338A>G 7:g.55160313A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2579304 2579304 2440641 NS NS NS NS malignant_melanoma NS NS NS n COSV51820036 COSM6005738 133244450 c.2288A>G p.N763S Substitution - Missense 38 7:55181432-55181432 + - PATHOGENIC .8643 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000415559.1:p.Asn763Ser ENST00000455089.5:c.2288A>G 7:g.55181432A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-J45330 2905663 2759919 NS NS NS NS malignant_melanoma NS NS NS n COSV105864518 COSM9991342 133264853 c.3137G>A p.G1046D Substitution - Missense 38 7:55202626-55202626 + - PATHOGENIC .98023 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Gly1046Asp ENST00000455089.5:c.3137G>A 7:g.55202626G>A EGFR ENST00000275493.6 3633 3236 2029028 2029028 1910910 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1716336 178390280 c.? p.T751L Substitution - Missense het + - Variant of unknown origin 23628817 NS NS EGFR ENST00000275493.6 3633 3236 6367 915989 833388 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51862232 COSM13195 99448288 c.2552T>C p.V851A Substitution - Missense 38 7:55191801-55191801 + - PATHOGENIC .97317 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000275493.2:p.Val851Ala ENST00000275493.6:c.2552T>C 7:g.55191801T>C EGFR ENST00000275493.6 3633 3236 1230488 1230488 1142302 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM26412 178384237 c.? p.G779S Substitution - Missense + - Variant of unknown origin 19536777 NS NS ENSP00000275493.2:p.Gly779Ser EGFR ENST00000275493.6 3633 3236 1964341 1964341 1850876 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM27111 178379606 c.? p.A871G Substitution - Missense + - Variant of unknown origin 23749122 NS NS ENSP00000275493.2:p.Ala871Gly EGFR ENST00000275493.6 3633 3236 2562115 2562115 2423511 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM5985088 178391596 c.? p.S768V Substitution - Missense + - Variant of unknown origin 23619604 surgery - NOS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862863 2862863 2718025 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51852379 COSM22942 133224094 c.2200G>T p.G734C Substitution - Missense 38 7:55181344-55181344 + - PATHOGENIC .98402 Variant of unknown origin 29489023 surgery - NOS NS ENSP00000415559.1:p.Gly734Cys ENST00000455089.5:c.2200G>T 7:g.55181344G>T EGFR ENST00000275493.6 3633 3236 2345025 2345025 2209697 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2344965 2344965 2209637 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1966338 1966338 1852831 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 23787800 surgery - NOS NS EGFR ENST00000275493.6 3633 3236 2344973 2344973 2209645 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2078490 2078490 1957209 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24378285 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2096195 2096195 1974259 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 2065005 2065005 1945082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21602 178380317 c.? p.L833V Substitution - Missense + - Variant of unknown origin 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu833Val EGFR ENST00000275493.6 3633 3236 1853889 1853889 1746492 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSM24861 178385327 c.? p.S720P Substitution - Missense + - Variant of unknown origin 23325582 surgery-fixed primary ENSP00000275493.2:p.Ser720Pro EGFR ENST00000275493.6 3633 3236 2637644 2637644 2498017 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM30755 178381649 c.? p.K860I Substitution - Missense + - Variant of unknown origin 28104619 circulating tumour recurrent 67 ENSP00000275493.2:p.Lys860Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-NYU184 1765199 1669519 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51830659 COSM370916 133236972 c.2435G>T p.G812V Substitution - Missense 38 7:55191819-55191819 + - PATHOGENIC .99007 Variant of unknown origin 22980975 surgery - NOS primary 77 ENSP00000415559.1:p.Gly812Val ENST00000455089.5:c.2435G>T 7:g.55191819G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1139185 1139185 1051749 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51772314 COSM27568 133206969 c.2252G>C p.G751A Substitution - Missense het 38 7:55181396-55181396 + - PATHOGENIC .95257 Variant of unknown origin 17695517 surgery - NOS recurrent 63 ENSP00000415559.1:p.Gly751Ala ENST00000455089.5:c.2252G>C 7:g.55181396G>C EGFR ENST00000275493.6 3633 3236 SK-MEL-28 1665022 1578472 skin NS NS NS malignant_melanoma NS NS NS n COSM49040 178380912 c.? p.P753S Substitution - Missense + - Variant of unknown origin 22515704 cell-line NS ENSP00000275493.2:p.Pro753Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 3638 915980 833379 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51866106 COSM13186 133280154 c.2120C>A p.S707Y Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98815 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000415559.1:p.Ser707Tyr ENST00000455089.5:c.2120C>A 7:g.55174792C>A EGFR ENST00000275493.6 3633 3236 2011149 2011149 1893787 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1684817 178382662 c.? p.G863D Substitution - Missense + - Variant of unknown origin 24002608 surgery - NOS NS ENSP00000275493.2:p.Gly863Asp EGFR ENST00000275493.6 3633 3236 BL-17-D48943 2905181 2759437 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864603 COSM9999789 99452104 c.2824G>A p.D942N Substitution - Missense 38 7:55198839-55198839 + - PATHOGENIC .9854 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000275493.2:p.Asp942Asn ENST00000275493.6:c.2824G>A 7:g.55198839G>A EGFR ENST00000275493.6 3633 3236 1471812 1471812 1395550 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51780223 COSM28511 99397578 c.2108T>C p.L703P Substitution - Missense 38 7:55173967-55173967 + - PATHOGENIC .90657 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000275493.2:p.Leu703Pro ENST00000275493.6:c.2108T>C 7:g.55173967T>C EGFR ENST00000275493.6 3633 3236 2749404 2749404 2608101 large_intestine appendix NS NS carcinoid-endocrine_tumour goblet_cell NS NS n COSM9936149 178388734 c.? p.N1112S Substitution - Missense + - Variant of unknown origin 29422640 surgery-fixed NS ENSP00000275493.2:p.Asn1112Ser EGFR ENST00000275493.6 3633 3236 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51841162 COSM1090865 99379527 c.594C>A p.S198R Substitution - Missense het 38 7:55151328-55151328 + - PATHOGENIC .8706 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000275493.2:p.Ser198Arg ENST00000275493.6:c.594C>A 7:g.55151328C>A EGFR ENST00000275493.6 3633 3236 1330084 1330084 1240569 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSM41666 178391713 c.? p.H870N Substitution - Missense + - Variant of unknown origin 20208477 surgery - NOS NS EGFR ENST00000275493.6 3633 3236 1853697 1853697 1746300 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSM24861 178385327 c.? p.S720P Substitution - Missense + - Variant of unknown origin 23325582 surgery-fixed primary ENSP00000275493.2:p.Ser720Pro EGFR ENST00000275493.6 3633 3236 1996545 1996545 1881754 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1666915 178387431 c.? p.L833F Substitution - Missense + - Variant of unknown origin 23922984 surgery-fixed NS ENSP00000275493.2:p.Leu833Phe EGFR ENST00000275493.6 3633 3236 2239184 2239184 2106716 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765947 COSM4302133 99394930 c.2077A>G p.T693A Substitution - Missense 38 7:55173936-55173936 + - PATHOGENIC .98314 Variant of unknown origin 25130612 surgery - NOS NS 66 ENSP00000275493.2:p.Thr693Ala ENST00000275493.6:c.2077A>G 7:g.55173936A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KYSE510 2395007 2257838 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51828940 COSM3266631 133208784 c.1970C>A p.A657D Substitution - Missense 38 7:55173964-55173964 + - PATHOGENIC .97734 Variant of unknown origin 24686850 cell-line NS ENSP00000415559.1:p.Ala657Asp ENST00000455089.5:c.1970C>A 7:g.55173964C>A EGFR ENST00000275493.6 3633 3236 1715966 1715966 1623528 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM26411 178380422 c.? p.S720F Substitution - Missense + - Variant of unknown origin 22760226 surgery - NOS NS 70 ENSP00000275493.2:p.Ser720Phe EGFR ENST00000275493.6 3633 3236 H1355 2776233 2634369 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51859380 COSM3266668 99379771 c.3477G>C p.Q1159H Substitution - Missense 38 7:55205461-55205461 + - PATHOGENIC .7741 Variant of unknown origin 29681454 NS NS 53 ENSP00000275493.2:p.Gln1159His ENST00000275493.6:c.3477G>C 7:g.55205461G>C EGFR ENST00000275493.6 3633 3236 1660249 1660249 1574522 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 21411993 surgery-fixed NS ENSP00000275493.2:p.Glu709Ala EGFR ENST00000275493.6 3633 3236 1083933 1083933 999098 lung NS NS NS carcinoma terminal_respiratory_unit_type_adenocarcinoma NS NS n COSM25819 178388682 c.? p.L858G Substitution - Missense + - Variant of unknown origin 17721266 surgery-fixed NS 56 EGFR ENST00000275493.6 3633 3236 2644146 2644146 2504433 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM6493923 178388219 c.? p.G109A Substitution - Missense + - Variant of unknown origin 28573640 surgery - NOS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 946820 946820 863343 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773889 COSM14069 133240281 c.2213C>T p.T738I Substitution - Missense 38 7:55181357-55181357 + - PATHOGENIC .96109 Variant of unknown origin 16204011 surgery-fixed NS ENSP00000415559.1:p.Thr738Ile ENST00000455089.5:c.2213C>T 7:g.55181357C>T EGFR ENST00000275493.6 3633 3236 TMIT_I_12 2765652 2623896 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV99034441 COSM7346604 99382858 c.1123G>A p.A375T Substitution - Missense 38 7:55156649-55156649 + - PATHOGENIC .97686 Variant of unknown origin 30239046 surgery-fixed NS ENSP00000275493.2:p.Ala375Thr ENST00000275493.6:c.1123G>A 7:g.55156649G>A EGFR ENST00000275493.6 3633 3236 1459447 1459447 1383390 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 20637128 surgery-fixed primary EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105111181 COSM9542450 133232875 c.61G>A p.A21T Substitution - Missense 38 7:55019338-55019338 + - NEUTRAL .06121 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000415559.1:p.Ala21Thr ENST00000455089.5:c.61G>A 7:g.55019338G>A EGFR ENST00000275493.6 3633 3236 1517361 1517361 1439745 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51807109 COSM88729 99394506 c.2158T>C p.S720P Substitution - Missense 38 7:55174017-55174017 + - PATHOGENIC .97572 Variant of unknown origin 21610522 NS primary 68 ENSP00000275493.2:p.Ser720Pro ENST00000275493.6:c.2158T>C 7:g.55174017T>C EGFR ENST00000275493.6 3633 3236 2860650 2860650 2715938 central_nervous_system choroid_plexus NS NS other choroid_plexus_papilloma NS NS n COSV105110915 COSM9568329 99415893 c.3263C>T p.P1088L Substitution - Missense 38 7:55202617-55202617 + - PATHOGENIC .97375 Variant of unknown origin 31612017 surgery-fixed NS 3 ENSP00000275493.2:p.Pro1088Leu ENST00000275493.6:c.3263C>T 7:g.55202617C>T EGFR ENST00000275493.6 3633 3236 1167997 1167997 1080239 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM28619 178383742 c.? p.V786M Substitution - Missense + - Variant of unknown origin 19059670 surgery-fixed primary 63 ENSP00000275493.2:p.Val786Met EGFR ENST00000275493.6 3633 3236 2522590 2522590 2384909 endometrium NS NS NS carcinoma adenocarcinoma NS NS n COSM5881413 178385455 c.? p.I462M Substitution - Missense + - Variant of unknown origin 27170661 surgery-fixed metastasis 50 EGFR ENST00000275493.6 3633 3236 1179043 1179043 1091005 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51813062 COSM12764 99374656 c.2569G>A p.G857R Substitution - Missense het 38 7:55191818-55191818 + - PATHOGENIC .98898 Variant of unknown origin 19190079 surgery-fixed primary 52 ENSP00000275493.2:p.Gly857Arg ENST00000275493.6:c.2569G>A 7:g.55191818G>A EGFR ENST00000275493.6 3633 3236 1094000 1094000 1008702 urinary_tract bladder NS NS carcinoma NS NS NS n COSV51833678 COSM26034 99434711 c.2624A>G p.K875R Substitution - Missense 38 7:55191873-55191873 + - PATHOGENIC .98545 Variant of unknown origin 17707060 surgery fresh/frozen NS ENSP00000275493.2:p.Lys875Arg ENST00000275493.6:c.2624A>G 7:g.55191873A>G EGFR ENST00000275493.6 3633 3236 2065005 2065005 1945082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM133107 178380316 c.? p.H835L Substitution - Missense + - Variant of unknown origin 24251405 surgery-fixed primary ENSP00000275493.2:p.His835Leu EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162178 1162178 1074510 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768381 COSM28509 133208577 c.1988A>T p.K663M Substitution - Missense 38 7:55173982-55173982 + - PATHOGENIC .98216 Variant of unknown origin 19020901 NS NS ENSP00000415559.1:p.Lys663Met ENST00000455089.5:c.1988A>T 7:g.55173982A>T EGFR ENST00000275493.6 3633 3236 2344976 2344976 2209648 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2344967 2344967 2209639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1592981 1592981 1513907 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51858252 COSM133205 99434811 c.2510A>G p.D837G Substitution - Missense 38 7:55191759-55191759 + - PATHOGENIC .986 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000275493.2:p.Asp837Gly ENST00000275493.6:c.2510A>G 7:g.55191759A>G EGFR ENST00000275493.6 3633 3236 AMO1 1889514 1778954 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV51777457 COSM1236015 99402374 c.627A>C p.K209N Substitution - Missense 38 7:55151361-55151361 + - NEUTRAL .14933 Variant of unknown origin 23396385 cell-line NS ENSP00000275493.2:p.Lys209Asn ENST00000275493.6:c.627A>C 7:g.55151361A>C EGFR ENST00000275493.6 3633 3236 KARPAS45 1760525 1665128 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51767338 COSM327145 99387235 c.227T>C p.L76P Substitution - Missense 38 7:55142424-55142424 + - PATHOGENIC .97399 Variant of unknown origin 22675565 cell-line NS ENSP00000275493.2:p.Leu76Pro ENST00000275493.6:c.227T>C 7:g.55142424T>C EGFR ENST00000275493.6 3633 3236 2264419 2264419 2131403 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR ENST00000275493.6 3633 3236 1542364 1542364 1464667 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 21782507 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2096192 2096192 1974256 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 2778783 2778783 2636837 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 29066915 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471805 1471805 1395543 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51847909 COSM53228 133245313 c.1988A>G p.K663R Substitution - Missense 38 7:55173982-55173982 + - PATHOGENIC .98155 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000415559.1:p.Lys663Arg ENST00000455089.5:c.1988A>G 7:g.55173982A>G EGFR ENST00000275493.6 3633 3236 Mel-RMU-DR6 1941945 1828866 skin NS NS NS malignant_melanoma NS NS NS n COSM49040 178380912 c.? p.P753S Substitution - Missense + - Variant of unknown origin 22437314 cell-line NS ENSP00000275493.2:p.Pro753Ser EGFR ENST00000275493.6 3633 3236 1330082 1330082 1240567 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51809790 COSM41665 99379857 c.2501T>C p.V834A Substitution - Missense 38 7:55191750-55191750 + - PATHOGENIC .97813 Variant of unknown origin 20208477 surgery - NOS NS ENSP00000275493.2:p.Val834Ala ENST00000275493.6:c.2501T>C 7:g.55191750T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162179 1162179 1074511 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51785698 COSM28510 133250001 c.2027G>C p.G676A Substitution - Missense 38 7:55174021-55174021 + - PATHOGENIC .98515 Variant of unknown origin 19020901 NS NS ENSP00000415559.1:p.Gly676Ala ENST00000455089.5:c.2027G>C 7:g.55174021G>C EGFR ENST00000275493.6 3633 3236 2344985 2344985 2209657 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1746449 1746449 1651425 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 22895145 NS NS 68 EGFR ENST00000275493.6 3633 3236 BL-18-X05124 2905679 2759935 NS NS NS NS malignant_melanoma NS NS NS n COSV105863708 COSM10000062 99374842 c.2741C>T p.P914L Substitution - Missense 38 7:55198756-55198756 + - PATHOGENIC .98269 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Pro914Leu ENST00000275493.6:c.2741C>T 7:g.55198756C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668463 1668463 1581756 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51787416 COSM219794 133210501 c.2364G>T p.L788F Substitution - Missense 38 7:55191748-55191748 + - PATHOGENIC .95793 Variant of unknown origin 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu788Phe ENST00000455089.5:c.2364G>T 7:g.55191748G>T EGFR ENST00000275493.6 3633 3236 2778593 2778593 2636647 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51771443 COSM12727 99378003 c.2551G>A p.V851I Substitution - Missense 38 7:55191800-55191800 + - PATHOGENIC .98898 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000275493.2:p.Val851Ile ENST00000275493.6:c.2551G>A 7:g.55191800G>A EGFR ENST00000275493.6 3633 3236 2860650 2860650 2715938 central_nervous_system choroid_plexus NS NS other choroid_plexus_papilloma NS NS n COSV51771443 COSM12727 99378003 c.2551G>A p.V851I Substitution - Missense 38 7:55191800-55191800 + - PATHOGENIC .98898 Variant of unknown origin 31612017 surgery-fixed NS 3 ENSP00000275493.2:p.Val851Ile ENST00000275493.6:c.2551G>A 7:g.55191800G>A EGFR ENST00000275493.6 3633 3236 2346491 2346491 2211154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 25687872 surgery-fixed NS ENSP00000275493.2:p.Glu709Ala EGFR ENST00000275493.6 3633 3236 2422804 2422804 2285726 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 25456362 NS NS ENSP00000275493.2:p.Glu709Ala EGFR ENST00000275493.6 3633 3236 2264363 2264363 2131347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR ENST00000275493.6 3633 3236 2345003 2345003 2209675 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2344968 2344968 2209640 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2096206 2096206 1974270 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 2345023 2345023 2209695 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1981030 1981030 1867266 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 23796143 surgery-fixed NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489065 1489065 1412385 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51778677 COSM85994 133276775 c.2441C>A p.A814D Substitution - Missense het 38 7:55191825-55191825 + - PATHOGENIC .98386 Variant of unknown origin 21317745 surgery-fixed NS 59 ENSP00000415559.1:p.Ala814Asp ENST00000455089.5:c.2441C>A 7:g.55191825C>A EGFR ENST00000275493.6 3633 3236 2345119 2345119 2209791 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-95-7039-01 1914100 1802382 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51829394 COSM28515 133262248 c.2628C>A p.S876R Substitution - Missense 38 7:55198778-55198778 + - .69453 Variant of unknown origin 417 fresh/frozen - NOS primary 54 ENSP00000415559.1:p.Ser876Arg ENST00000455089.5:c.2628C>A 7:g.55198778C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 UM-SCC-17B 2296307 2161910 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825836 COSM4599146 133229875 c.345T>A p.N115K Substitution - Missense 38 7:55143409-55143409 + - NEUTRAL .2671 Variant of unknown origin 25275298 cell-line NS 47 ENSP00000415559.1:p.Asn115Lys ENST00000455089.5:c.345T>A 7:g.55143409T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166417 1166417 1078731 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51815916 COSM28600 133220795 c.1960C>T p.P654S Substitution - Missense het 38 7:55173954-55173954 + - PATHOGENIC .97389 Variant of unknown origin 16870303 surgery - NOS NS 75 ENSP00000415559.1:p.Pro654Ser ENST00000455089.5:c.1960C>T 7:g.55173954C>T EGFR ENST00000275493.6 3633 3236 2689570 2689570 2548547 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS n COSV51806541 COSM6904300 99385956 c.3004A>G p.M1002V Substitution - Missense het 38 7:55201245-55201245 + - PATHOGENIC .98099 Variant of unknown origin 27246973 blood-bone marrow primary 37 ENSP00000275493.2:p.Met1002Val ENST00000275493.6:c.3004A>G 7:g.55201245A>G EGFR ENST00000275493.6 3633 3236 1541364 1541364 1463678 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM97093 178385811 c.? p.P772S Substitution - Missense + - Variant of unknown origin 21768463 surgery - NOS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166448 1166448 1078762 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51776171 COSM28605 133254151 c.2476G>A p.A826T Substitution - Missense het 38 7:55191860-55191860 + - PATHOGENIC .9853 Variant of unknown origin 16870303 surgery - NOS NS 33 ENSP00000415559.1:p.Ala826Thr ENST00000455089.5:c.2476G>A 7:g.55191860G>A EGFR ENST00000275493.6 3633 3236 2264421 2264421 2131405 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR ENST00000275493.6 3633 3236 1638674 1638674 1554673 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 22321542 surgery-fixed NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675155 2675155 2534429 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766300 COSM6849765 133205616 c.2102A>G p.E701G Substitution - Missense 38 7:55174774-55174774 + - PATHOGENIC .97324 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000415559.1:p.Glu701Gly ENST00000455089.5:c.2102A>G 7:g.55174774A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DM17 2466858 2329689 skin arm NS NS malignant_melanoma desmoplastic NS NS n COSV51804378 COSM5608346 133259465 c.1423C>T p.P475S Substitution - Missense 38 7:55161558-55161558 + - PATHOGENIC .7492 Variant of unknown origin 26343386 surgery-fixed NS 74 ENSP00000415559.1:p.Pro475Ser ENST00000455089.5:c.1423C>T 7:g.55161558C>T EGFR ENST00000275493.6 3633 3236 2626094 2626094 2486506 lung NS NS NS carcinoid-endocrine_tumour atypical NS NS n COSV51823853 COSM6191491 99373488 c.311T>A p.L104Q Substitution - Missense hom 38 7:55143375-55143375 + - PATHOGENIC .99116 Variant of unknown origin 26645239 surgery-fixed NS ENSP00000275493.2:p.Leu104Gln ENST00000275493.6:c.311T>A 7:g.55143375T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899356 899356 816968 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51866714 COSM12372 133279831 c.2009T>G p.I670S Substitution - Missense 38 7:55174003-55174003 + - PATHOGENIC .88145 Variant of unknown origin 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Ile670Ser ENST00000455089.5:c.2009T>G 7:g.55174003T>G EGFR ENST00000275493.6 3633 3236 2083466 2083466 1961749 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM88795 178382307 c.? p.K754E Substitution - Missense + - Variant of unknown origin 24481316 surgery - NOS primary 33 ENSP00000275493.2:p.Lys754Glu EGFR ENST00000275493.6 3633 3236 2579677 2579677 2441014 NS NS NS NS malignant_melanoma NS NS NS n COSV51804547 COSM6005741 99407605 c.2298G>A p.M766I Substitution - Missense 38 7:55181307-55181307 + - PATHOGENIC .98539 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000275493.2:p.Met766Ile ENST00000275493.6:c.2298G>A 7:g.55181307G>A EGFR ENST00000275493.6 3633 3236 2290971 2290971 2157036 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25264883 NS primary EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PGBM27 1630925 1547795 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51858275 COSM506581 133268278 c.2815G>A p.D939N Substitution - Missense 38 7:55201191-55201191 + - PATHOGENIC .99577 Variant of unknown origin 22286061 surgery - NOS NS 9 ENSP00000415559.1:p.Asp939Asn ENST00000455089.5:c.2815G>A 7:g.55201191G>A EGFR ENST00000275493.6 3633 3236 2096203 2096203 1974267 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 1914967 1914967 1802969 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 23590575 surgery-fixed NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2579503 2579503 2440840 NS NS NS NS malignant_melanoma NS NS NS n COSV51849040 COSM6005740 133238977 c.353C>T p.A118V Substitution - Missense 38 7:55143417-55143417 + - PATHOGENIC .99538 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000415559.1:p.Ala118Val ENST00000455089.5:c.353C>T 7:g.55143417C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NKI_LPSCC_59 2810565 2667226 upper_aerodigestive_tract pharynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV99296441 COSM9178873 133237252 c.2908G>A p.E970K Substitution - Missense 38 7:55201284-55201284 + - PATHOGENIC .99529 Variant of unknown origin 29884412 surgery fresh/frozen primary ENSP00000415559.1:p.Glu970Lys ENST00000455089.5:c.2908G>A 7:g.55201284G>A EGFR ENST00000275493.6 3633 3236 2862101 2862101 2717303 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51805944 COSM28931 99449706 c.2533G>A p.V845M Substitution - Missense 38 7:55191782-55191782 + - PATHOGENIC .98912 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000275493.2:p.Val845Met ENST00000275493.6:c.2533G>A 7:g.55191782G>A EGFR ENST00000275493.6 3633 3236 1083335 1083335 998500 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM25870 178388442 c.? p.D807N Substitution - Missense + - Variant of unknown origin 17596643 surgery-fixed NS ENSP00000275493.2:p.Asp807Asn EGFR ENST00000275493.6 3633 3236 2898401 2898401 2752679 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM6056886 178380139 c.? p.D761N Substitution - Missense + - Variant of unknown origin 23800712 fixed - NOS NS ENSP00000275493.2:p.Asp761Asn EGFR_ENST00000455089 ENST00000455089.5 3276 3236 907090 907090 824602 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51833668 COSM12675 133253212 c.2440G>A p.A814T Substitution - Missense het 38 7:55191824-55191824 + - PATHOGENIC .98898 Variant of unknown origin 15710947 surgery-fixed NS ENSP00000415559.1:p.Ala814Thr ENST00000455089.5:c.2440G>A 7:g.55191824G>A EGFR ENST00000275493.6 3633 3236 1484380 1484380 1408006 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSM21621 178387289 c.? p.F856L Substitution - Missense + - Variant of unknown origin 21266046 surgery-fixed primary 67 ENSP00000275493.2:p.Phe856Leu EGFR ENST00000275493.6 3633 3236 C331 2897780 2752079 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV99296441 COSM9178873 99410228 c.3043G>A p.E1015K Substitution - Missense 38 7:55201284-55201284 + - PATHOGENIC .99529 Variant of unknown origin 31477716 surgery-fixed NS 73 ENSP00000275493.2:p.Glu1015Lys ENST00000275493.6:c.3043G>A 7:g.55201284G>A EGFR ENST00000275493.6 3633 3236 2603468 2603468 2464359 central_nervous_system brain NS NS glioma oligoastrocytoma_Grade_III anaplastic NS n COSM6024078 178390374 c.? p.E317D Substitution - Missense + - Variant of unknown origin 28042970 surgery-fixed NS 59 ENSP00000275493.2:p.Glu317Asp EGFR ENST00000275493.6 3633 3236 2659760 2659760 2519918 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766584 COSM12371 99382498 c.2126A>T p.E709V Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97538 Variant of unknown origin 28744312 surgery-fixed NS ENSP00000275493.2:p.Glu709Val ENST00000275493.6:c.2126A>T 7:g.55173985A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 18 2570181 2431478 skin face NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51818444 COSM5991528 133243254 c.2180C>T p.P727L Substitution - Missense 38 7:55181324-55181324 + - PATHOGENIC .97247 Variant of unknown origin 27311873 surgery-fixed NS 53 ENSP00000415559.1:p.Pro727Leu ENST00000455089.5:c.2180C>T 7:g.55181324C>T EGFR ENST00000275493.6 3633 3236 2862270 2862270 2717460 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM9572587 178384052 c.? p.V774L Substitution - Missense + - Variant of unknown origin 25969368 surgery-fixed primary ENSP00000275493.2:p.Val774Leu EGFR ENST00000275493.6 3633 3236 1705345 1705345 1613329 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51769837 COSM249780 99387447 c.2410G>A p.E804K Substitution - Missense 38 7:55181419-55181419 + - PATHOGENIC .97109 Variant of unknown origin 22722798 surgery - NOS recurrent 71 ENSP00000275493.2:p.Glu804Lys ENST00000275493.6:c.2410G>A 7:g.55181419G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CC34 2766428 2624647 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV99034450 COSM7342223 133251665 c.2663T>C p.L888P Substitution - Missense 38 7:55198813-55198813 + - PATHOGENIC .98175 Variant of unknown origin 29844865 surgery fresh/frozen NS 69 ENSP00000415559.1:p.Leu888Pro ENST00000455089.5:c.2663T>C 7:g.55198813T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899355 899355 816967 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766584 COSM12371 133211112 c.1991A>T p.E664V Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97538 Variant of unknown origin 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Glu664Val ENST00000455089.5:c.1991A>T 7:g.55173985A>T EGFR ENST00000275493.6 3633 3236 2757341 2757341 2615978 lung right NS NS carcinoma adenocarcinoma NS NS n COSM30755 178381649 c.? p.K860I Substitution - Missense + - Variant of unknown origin 28274743 surgery - NOS NS 41 ENSP00000275493.2:p.Lys860Ile EGFR ENST00000275493.6 3633 3236 2579503 2579503 2440840 NS NS NS NS malignant_melanoma NS NS NS n COSV51849040 COSM6005740 99412587 c.353C>T p.A118V Substitution - Missense 38 7:55143417-55143417 + - PATHOGENIC .99538 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000275493.2:p.Ala118Val ENST00000275493.6:c.353C>T 7:g.55143417C>T EGFR ENST00000275493.6 3633 3236 2672937 2672937 2532449 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1716337 178378584 c.? p.A289V Substitution - Missense + - Variant of unknown origin 26191234 surgery-fixed primary ENSP00000275493.2:p.Ala289Val EGFR ENST00000275493.6 3633 3236 2603457 2603457 2464348 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSM1716337 178378584 c.? p.A289V Substitution - Missense + - Variant of unknown origin 28042970 surgery-fixed NS 5 ENSP00000275493.2:p.Ala289Val EGFR ENST00000275493.6 3633 3236 2026223 2026223 1908312 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51817197 COSM1716258 99433895 c.2603A>T p.E868V Substitution - Missense het 38 7:55191852-55191852 + - PATHOGENIC .96496 Variant of unknown origin 24040454 surgery-fixed NS ENSP00000275493.2:p.Glu868Val ENST00000275493.6:c.2603A>T 7:g.55191852A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1113001 1113001 1026509 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51780009 COSM27042 133221419 c.2147A>G p.D716G Substitution - Missense 38 7:55174819-55174819 + - PATHOGENIC .9946 Variant of unknown origin 18302229 surgery - NOS NS 68 ENSP00000415559.1:p.Asp716Gly ENST00000455089.5:c.2147A>G 7:g.55174819A>G EGFR ENST00000275493.6 3633 3236 DM17 2466858 2329689 skin arm NS NS malignant_melanoma desmoplastic NS NS n COSV51804378 COSM5608346 99436559 c.1558C>T p.P520S Substitution - Missense 38 7:55161558-55161558 + - PATHOGENIC .7492 Variant of unknown origin 26343386 surgery-fixed NS 74 ENSP00000275493.2:p.Pro520Ser ENST00000275493.6:c.1558C>T 7:g.55161558C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 RDES 2294586 2160613 bone NS NS NS Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour NS NS NS y COSV51793186 COSM4587483 133252467 c.1663A>G p.M555V Substitution - Missense 38 7:55165355-55165355 + - PATHOGENIC .89999 Variant of unknown origin 25186949 cell-line NS ENSP00000415559.1:p.Met555Val ENST00000455089.5:c.1663A>G 7:g.55165355A>G EGFR ENST00000275493.6 3633 3236 1602599 1602599 1521935 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM133708 178380057 c.? p.V774M Substitution - Missense + - Variant of unknown origin 22082647 surgery-fixed NS 45 ENSP00000275493.2:p.Val774Met EGFR ENST00000275493.6 3633 3236 2064729 2064729 1944806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1717880 178389101 c.? p.E758K Substitution - Missense + - Variant of unknown origin 24251405 surgery-fixed primary ENSP00000275493.2:p.Glu758Lys EGFR ENST00000275493.6 3633 3236 2659761 2659761 2519919 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51802260 COSM6506511 99435175 c.2132A>G p.E711G Substitution - Missense 38 7:55173991-55173991 + - PATHOGENIC .97458 Variant of unknown origin 28744312 surgery-fixed NS ENSP00000275493.2:p.Glu711Gly ENST00000275493.6:c.2132A>G 7:g.55173991A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1113000 1113000 1026509 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51780009 COSM27042 133221419 c.2147A>G p.D716G Substitution - Missense 38 7:55174819-55174819 + - PATHOGENIC .9946 Variant of unknown origin 18302229 surgery - NOS NS 68 ENSP00000415559.1:p.Asp716Gly ENST00000455089.5:c.2147A>G 7:g.55174819A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-273-tumor 2819121 2675420 meninges NS NS NS meningioma anaplastic NS NS n COSV104369217 COSM9267459 133239215 c.1279G>A p.A427T Substitution - Missense 38 7:55160254-55160254 + - PATHOGENIC .94147 Variant of unknown origin 28713588 surgery - NOS NS ENSP00000415559.1:p.Ala427Thr ENST00000455089.5:c.1279G>A 7:g.55160254G>A EGFR ENST00000275493.6 3633 3236 1517405 1517405 1439789 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM30755 178381649 c.? p.K860I Substitution - Missense + - Variant of unknown origin 21610522 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Lys860Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778593 2778593 2636647 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51771443 COSM12727 133206095 c.2416G>A p.V806I Substitution - Missense 38 7:55191800-55191800 + - PATHOGENIC .98898 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000415559.1:p.Val806Ile ENST00000455089.5:c.2416G>A 7:g.55191800G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2860650 2860650 2715938 central_nervous_system choroid_plexus NS NS other choroid_plexus_papilloma NS NS n COSV51771443 COSM12727 133206095 c.2416G>A p.V806I Substitution - Missense 38 7:55191800-55191800 + - PATHOGENIC .98898 Variant of unknown origin 31612017 surgery-fixed NS 3 ENSP00000415559.1:p.Val806Ile ENST00000455089.5:c.2416G>A 7:g.55191800G>A EGFR ENST00000275493.6 3633 3236 1729747 1729747 1635718 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM255172 178378410 c.? p.S811P Substitution - Missense + - Variant of unknown origin 22805266 NS NS EGFR ENST00000275493.6 3633 3236 DM26 2466862 2329693 skin scalp NS NS malignant_melanoma desmoplastic NS NS n COSV51820811 COSM5611257 99435440 c.1788_1789delinsAA p.A597T Substitution - Missense 38 7:55165345-55165346 + - Variant of unknown origin 26343386 surgery-fixed NS 79 ENSP00000275493.2:p.Ala597Thr ENST00000275493.6:c.1788_1789delinsAA 7:g.55165345_55165346delinsAA EGFR ENST00000275493.6 3633 3236 2667851 2667851 2527513 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1716337 178378584 c.? p.A289V Substitution - Missense + - Variant of unknown origin 28663030 surgery-fixed secondary ENSP00000275493.2:p.Ala289Val EGFR ENST00000275493.6 3633 3236 2525709 2525709 2387897 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM5885108 178388587 c.? p.K754Q Substitution - Missense + - Variant of unknown origin 27304188 NS NS EGFR ENST00000275493.6 3633 3236 1230491 1230491 1142305 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM30755 178381649 c.? p.K860I Substitution - Missense + - Variant of unknown origin 19536777 NS NS ENSP00000275493.2:p.Lys860Ile EGFR ENST00000275493.6 3633 3236 1230489 1230489 1142303 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM30758 178390285 c.? p.K806A Substitution - Missense + - Variant of unknown origin 19536777 NS NS EGFR ENST00000275493.6 3633 3236 2856978 2856978 2712278 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSM9856979 178383744 c.? p.A750V Substitution - Missense + - Variant of unknown origin 32314446 surgery-fixed primary 77 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-G33297 2905054 2759310 NS NS NS NS malignant_melanoma NS NS NS n COSV105863803 COSM9997894 133279787 c.2951C>T p.T984M Substitution - Missense 38 7:55201327-55201327 + - PATHOGENIC .96845 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000415559.1:p.Thr984Met ENST00000455089.5:c.2951C>T 7:g.55201327C>T EGFR ENST00000275493.6 3633 3236 924349 924349 841124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51801258 COSM13553 99388229 c.2572_2573inv p.L858R Substitution - Missense 38 7:55191821-55191822 + - Variant of unknown origin 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2572_2573inv 7:g.55191821_55191822inv EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2689570 2689570 2548547 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS n COSV51806541 COSM6904300 133214363 c.2869A>G p.M957V Substitution - Missense het 38 7:55201245-55201245 + - PATHOGENIC .98099 Variant of unknown origin 27246973 blood-bone marrow primary 37 ENSP00000415559.1:p.Met957Val ENST00000455089.5:c.2869A>G 7:g.55201245A>G EGFR ENST00000275493.6 3633 3236 1837421 1837421 1731620 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21603 178379091 c.? p.R776H Substitution - Missense + - Variant of unknown origin 23242437 NS NS 81 ENSP00000275493.2:p.Arg776His EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51841162 COSM1090865 133207687 c.459C>A p.S153R Substitution - Missense het 38 7:55151328-55151328 + - PATHOGENIC .8706 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000415559.1:p.Ser153Arg ENST00000455089.5:c.459C>A 7:g.55151328C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51841184 COSM1090877 133207701 c.1486C>A p.L496I Substitution - Missense het 38 7:55161621-55161621 + - NEUTRAL .01946 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000415559.1:p.Leu496Ile ENST00000455089.5:c.1486C>A 7:g.55161621C>A EGFR ENST00000275493.6 3633 3236 983763 983763 899481 oesophagus NS NS NS carcinoma adenocarcinoma NS NS n COSM18485 178387208 c.? p.A743P Substitution - Missense + - Variant of unknown origin 16707764 surgery fresh/frozen primary EGFR ENST00000275493.6 3633 3236 2841802 2841802 2697351 soft_tissue fibrous_tissue_and_uncertain_origin NS NS desmoid_tumour-fibromatosis NS NS NS n COSV104576751 COSM9414780 99413564 c.3187G>A p.D1063N Substitution - Missense 38 7:55202541-55202541 + - PATHOGENIC .93865 Variant of unknown origin 32099073 surgery-fixed NS ENSP00000275493.2:p.Asp1063Asn ENST00000275493.6:c.3187G>A 7:g.55202541G>A EGFR ENST00000275493.6 3633 3236 8 2760115 2618648 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51797913 COSM7339051 99383892 c.2505C>A p.H835Q Substitution - Missense 38 7:55191754-55191754 + - PATHOGENIC .83351 Variant of unknown origin 29876005 surgery-fixed NS ENSP00000275493.2:p.His835Gln ENST00000275493.6:c.2505C>A 7:g.55191754C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2860650 2860650 2715938 central_nervous_system choroid_plexus NS NS other choroid_plexus_papilloma NS NS n COSV51813062 COSM12764 133203122 c.2434G>A p.G812R Substitution - Missense 38 7:55191818-55191818 + - PATHOGENIC .98898 Variant of unknown origin 31612017 surgery-fixed NS 3 ENSP00000415559.1:p.Gly812Arg ENST00000455089.5:c.2434G>A 7:g.55191818G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239184 2239184 2106716 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765947 COSM4302133 133221552 c.1942A>G p.T648A Substitution - Missense 38 7:55173936-55173936 + - PATHOGENIC .98314 Variant of unknown origin 25130612 surgery - NOS NS 66 ENSP00000415559.1:p.Thr648Ala ENST00000455089.5:c.1942A>G 7:g.55173936A>G EGFR ENST00000275493.6 3633 3236 2675163 2675163 2534437 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51797702 COSM6849769 99412314 c.2234A>C p.K745T Substitution - Missense 38 7:55174771-55174771 + - PATHOGENIC .99622 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000275493.2:p.Lys745Thr ENST00000275493.6:c.2234A>C 7:g.55174771A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1330078 1330078 1240563 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51847775 COSM41663 133227649 c.2327T>C p.I776T Substitution - Missense het 38 7:55181471-55181471 + - PATHOGENIC .92352 Variant of unknown origin 20208477 surgery - NOS NS ENSP00000415559.1:p.Ile776Thr ENST00000455089.5:c.2327T>C 7:g.55181471T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862101 2862101 2717303 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51805944 COSM28931 133272811 c.2398G>A p.V800M Substitution - Missense 38 7:55191782-55191782 + - PATHOGENIC .98912 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000415559.1:p.Val800Met ENST00000455089.5:c.2398G>A 7:g.55191782G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2860650 2860650 2715938 central_nervous_system choroid_plexus NS NS other choroid_plexus_papilloma NS NS n COSV105110915 COSM9568329 133241613 c.3128C>T p.P1043L Substitution - Missense 38 7:55202617-55202617 + - PATHOGENIC .97375 Variant of unknown origin 31612017 surgery-fixed NS 3 ENSP00000415559.1:p.Pro1043Leu ENST00000455089.5:c.3128C>T 7:g.55202617C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 912834 912834 830326 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51813062 COSM12764 133203122 c.2434G>A p.G812R Substitution - Missense het 38 7:55191818-55191818 + - PATHOGENIC .98898 Variant of unknown origin 15863375 surgery-fixed primary 75 ENSP00000415559.1:p.Gly812Arg ENST00000455089.5:c.2434G>A 7:g.55191818G>A EGFR ENST00000275493.6 3633 3236 1996549 1996549 1881758 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1666915 178387431 c.? p.L833F Substitution - Missense + - Variant of unknown origin 23922984 surgery-fixed NS ENSP00000275493.2:p.Leu833Phe EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1094000 1094000 1008702 urinary_tract bladder NS NS carcinoma NS NS NS n COSV51833678 COSM26034 133257820 c.2489A>G p.K830R Substitution - Missense 38 7:55191873-55191873 + - PATHOGENIC .98545 Variant of unknown origin 17707060 surgery fresh/frozen NS ENSP00000415559.1:p.Lys830Arg ENST00000455089.5:c.2489A>G 7:g.55191873A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TMIT_I_12 2765652 2623896 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV99034441 COSM7346604 133211465 c.988G>A p.A330T Substitution - Missense 38 7:55156649-55156649 + - PATHOGENIC .97686 Variant of unknown origin 30239046 surgery-fixed NS ENSP00000415559.1:p.Ala330Thr ENST00000455089.5:c.988G>A 7:g.55156649G>A EGFR ENST00000275493.6 3633 3236 1047971 1047971 964199 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM23623 178382228 c.? p.H773R Substitution - Missense + - Variant of unknown origin 17337084 surgery-fixed NS ENSP00000275493.2:p.His773Arg EGFR ENST00000275493.6 3633 3236 2659760 2659760 2519918 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51771654 COSM6506512 99391716 c.2140A>G p.K714E Substitution - Missense 38 7:55173999-55173999 + - PATHOGENIC .9657 Variant of unknown origin 28744312 surgery-fixed NS ENSP00000275493.2:p.Lys714Glu ENST00000275493.6:c.2140A>G 7:g.55173999A>G EGFR ENST00000275493.6 3633 3236 1500583 1500583 1423462 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51765742 COSM87019 99377391 c.2402A>G p.Y801C Substitution - Missense het 38 7:55181411-55181411 + - PATHOGENIC .95822 Variant of unknown origin 21436633 surgery - NOS NS 83 ENSP00000275493.2:p.Tyr801Cys ENST00000275493.6:c.2402A>G 7:g.55181411A>G EGFR ENST00000275493.6 3633 3236 1475462 1475462 1399161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM53308 178382874 c.? p.L858P Substitution - Missense + - Variant of unknown origin 21111508 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1661391 1661391 1575006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51845318 COSM214350 133208295 c.2467G>A p.E823K Substitution - Missense het 38 7:55191851-55191851 + - PATHOGENIC .98896 Variant of unknown origin 22483783 surgery-fixed NS 49 ENSP00000415559.1:p.Glu823Lys ENST00000455089.5:c.2467G>A 7:g.55191851G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00243T00243 2857340 2712640 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105111181 COSM9542450 99406489 c.61G>A p.A21T Substitution - Missense 38 7:55019338-55019338 + - NEUTRAL .06121 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000275493.2:p.Ala21Thr ENST00000275493.6:c.61G>A 7:g.55019338G>A EGFR ENST00000275493.6 3633 3236 2522580 2522580 2384899 endometrium NS NS NS carcinoma adenocarcinoma NS NS n COSM5881412 178389365 c.? p.T605A Substitution - Missense + - Variant of unknown origin 27170661 surgery-fixed primary 60 EGFR ENST00000275493.6 3633 3236 TCGA-22-4601-01 1780882 1684881 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51789475 COSM747423 99423907 c.3056C>T p.P1019L Substitution - Missense 38 7:55201297-55201297 + - PATHOGENIC .99234 Variant of unknown origin 418 fresh/frozen - NOS primary 73 ENSP00000275493.2:p.Pro1019Leu ENST00000275493.6:c.3056C>T 7:g.55201297C>T EGFR ENST00000275493.6 3633 3236 1592964 1592964 1513890 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51801589 COSM133199 99381946 c.2246A>G p.E749G Substitution - Missense 38 7:55174783-55174783 + - PATHOGENIC .9946 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000275493.2:p.Glu749Gly ENST00000275493.6:c.2246A>G 7:g.55174783A>G EGFR ENST00000275493.6 3633 3236 5330 915979 833378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51861323 COSM13187 99458071 c.2548C>A p.H850N Substitution - Missense 38 7:55191797-55191797 + - PATHOGENIC .98386 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000275493.2:p.His850Asn ENST00000275493.6:c.2548C>A 7:g.55191797C>A EGFR ENST00000275493.6 3633 3236 1160969 1160969 1073305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM28486 178388751 c.? p.G857R Substitution - Missense + - Variant of unknown origin 19002495 surgery-fixed primary 71 ENSP00000275493.2:p.Gly857Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 AMO1 1889514 1778954 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV51777457 COSM1236015 133227966 c.492A>C p.K164N Substitution - Missense 38 7:55151361-55151361 + - NEUTRAL .14933 Variant of unknown origin 23396385 cell-line NS ENSP00000415559.1:p.Lys164Asn ENST00000455089.5:c.492A>C 7:g.55151361A>C EGFR ENST00000275493.6 3633 3236 1094002 1094002 1008704 urinary_tract bladder NS NS carcinoma NS NS NS n COSV51789830 COSM26035 99383994 c.2591C>A p.A864E Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .95798 Variant of unknown origin 17707060 surgery fresh/frozen NS ENSP00000275493.2:p.Ala864Glu ENST00000275493.6:c.2591C>A 7:g.55191840C>A EGFR ENST00000275493.6 3633 3236 2778590 2778590 2636644 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV99296732 COSM7410339 99412419 c.2452T>C p.C818R Substitution - Missense 38 7:55181461-55181461 + - PATHOGENIC .95365 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000275493.2:p.Cys818Arg ENST00000275493.6:c.2452T>C 7:g.55181461T>C EGFR ENST00000275493.6 3633 3236 P13_20580_7_S4_R1_001 2823451 2679304 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51846371 COSM7338932 99430450 c.2918G>A p.R973Q Substitution - Missense 38 7:55200385-55200385 + - PATHOGENIC .99379 Variant of unknown origin 31854063 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Arg973Gln ENST00000275493.6:c.2918G>A 7:g.55200385G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1517361 1517361 1439745 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51807109 COSM88729 133221325 c.2023T>C p.S675P Substitution - Missense 38 7:55174017-55174017 + - PATHOGENIC .97572 Variant of unknown origin 21610522 NS primary 68 ENSP00000415559.1:p.Ser675Pro ENST00000455089.5:c.2023T>C 7:g.55174017T>C EGFR ENST00000275493.6 3633 3236 1047966 1047966 964194 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM23623 178382228 c.? p.H773R Substitution - Missense + - Variant of unknown origin 17337084 surgery-fixed NS ENSP00000275493.2:p.His773Arg EGFR ENST00000275493.6 3633 3236 NPC0001PT00389T00389 2857373 2712673 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 99406505 c.1162G>A p.D388N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000275493.2:p.Asp388Asn ENST00000275493.6:c.1162G>A 7:g.55156787G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471812 1471812 1395550 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51780223 COSM28511 133223277 c.1973T>C p.L658P Substitution - Missense 38 7:55173967-55173967 + - PATHOGENIC .90657 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000415559.1:p.Leu658Pro ENST00000455089.5:c.1973T>C 7:g.55173967T>C EGFR ENST00000275493.6 3633 3236 1330078 1330078 1240563 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51847775 COSM41663 99402092 c.2462T>C p.I821T Substitution - Missense het 38 7:55181471-55181471 + - PATHOGENIC .92352 Variant of unknown origin 20208477 surgery - NOS NS ENSP00000275493.2:p.Ile821Thr ENST00000275493.6:c.2462T>C 7:g.55181471T>C EGFR ENST00000275493.6 3633 3236 2841802 2841802 2697351 soft_tissue fibrous_tissue_and_uncertain_origin NS NS desmoid_tumour-fibromatosis NS NS NS n COSV104576752 COSM9414781 99413570 c.3191G>A p.S1064N Substitution - Missense 38 7:55202545-55202545 + - PATHOGENIC .89459 Variant of unknown origin 32099073 surgery-fixed NS ENSP00000275493.2:p.Ser1064Asn ENST00000275493.6:c.3191G>A 7:g.55202545G>A EGFR ENST00000275493.6 3633 3236 2822189 2822189 2678049 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21602 178380317 c.? p.L833V Substitution - Missense + - Variant of unknown origin 26373574 fixed - NOS NS ENSP00000275493.2:p.Leu833Val EGFR ENST00000275493.6 3633 3236 2579301 2579301 2440638 NS NS NS NS malignant_melanoma NS NS NS n COSV51772282 COSM133202 99384247 c.2336G>A p.G779D Substitution - Missense 38 7:55181345-55181345 + - PATHOGENIC .98244 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000275493.2:p.Gly779Asp ENST00000275493.6:c.2336G>A 7:g.55181345G>A EGFR ENST00000275493.6 3633 3236 1668455 1668455 1581748 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51783814 COSM219793 99438383 c.2598G>T p.E866D Substitution - Missense 38 7:55191847-55191847 + - PATHOGENIC .94716 Variant of unknown origin 22523180 surgery - NOS NS ENSP00000275493.2:p.Glu866Asp ENST00000275493.6:c.2598G>T 7:g.55191847G>T EGFR ENST00000275493.6 3633 3236 2290972 2290972 2157037 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25264883 NS primary EGFR ENST00000275493.6 3633 3236 2118475 2118475 1992710 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24568474 surgery-fixed NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KARPAS45 1760525 1665128 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51767338 COSM327145 133215437 c.227T>C p.L76P Substitution - Missense 38 7:55142424-55142424 + - PATHOGENIC .97399 Variant of unknown origin 22675565 cell-line NS ENSP00000415559.1:p.Leu76Pro ENST00000455089.5:c.227T>C 7:g.55142424T>C EGFR ENST00000275493.6 3633 3236 2345115 2345115 2209787 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2264418 2264418 2131402 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR ENST00000275493.6 3633 3236 2816303 2816303 2672655 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSM9225762 178387525 c.? p.T502I Substitution - Missense + - Variant of unknown origin 31628675 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 BL-17-J18549 2905628 2759884 NS NS NS NS malignant_melanoma NS NS NS n COSV105864529 COSM9997996 99446878 c.2924C>T p.P975L Substitution - Missense 38 7:55200391-55200391 + - PATHOGENIC .98929 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Pro975Leu ENST00000275493.6:c.2924C>T 7:g.55200391C>T EGFR ENST00000275493.6 3633 3236 Mel-RMU-DR2 1941943 1828866 skin NS NS NS malignant_melanoma NS NS NS n COSM49040 178380912 c.? p.P753S Substitution - Missense + - Variant of unknown origin 22437314 cell-line NS ENSP00000275493.2:p.Pro753Ser EGFR ENST00000275493.6 3633 3236 2788200 2788200 2645582 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSM7450305 178382232 c.? p.Y891D Substitution - Missense + - Variant of unknown origin 30922578 pleural effusion recurrent 55 EGFR ENST00000275493.6 3633 3236 2559408 2559408 2420832 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM1666915 178387431 c.? p.L833F Substitution - Missense + - Variant of unknown origin 24158231 surgery fresh/frozen NS 69 ENSP00000275493.2:p.Leu833Phe EGFR ENST00000275493.6 3633 3236 2644149 2644149 2504436 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM6493926 178383483 c.? p.E519D Substitution - Missense + - Variant of unknown origin 28573640 surgery - NOS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-18-X05124 2905679 2759935 NS NS NS NS malignant_melanoma NS NS NS n COSV105863708 COSM10000062 133203261 c.2606C>T p.P869L Substitution - Missense 38 7:55198756-55198756 + - PATHOGENIC .98269 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Pro869Leu ENST00000455089.5:c.2606C>T 7:g.55198756C>T EGFR ENST00000275493.6 3633 3236 1179043 1179043 1091005 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51818061 COSM28930 99374648 c.2354C>A p.T785N Substitution - Missense hom 38 7:55181363-55181363 + - PATHOGENIC .95016 Variant of unknown origin 19190079 surgery-fixed primary 52 ENSP00000275493.2:p.Thr785Asn ENST00000275493.6:c.2354C>A 7:g.55181363C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592981 1592981 1513907 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51858252 COSM133205 133257913 c.2375A>G p.D792G Substitution - Missense 38 7:55191759-55191759 + - PATHOGENIC .986 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000415559.1:p.Asp792Gly ENST00000455089.5:c.2375A>G 7:g.55191759A>G EGFR ENST00000275493.6 3633 3236 042 2218435 2086446 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM4169571 178387084 c.? p.A763D Substitution - Missense + - Variant of unknown origin 25078279 surgery fresh/frozen primary 80 EGFR ENST00000275493.6 3633 3236 1672416 1672416 1585470 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM24862 178381344 c.? p.I706T Substitution - Missense + - Variant of unknown origin 21729655 fine needle aspirate primary 45 EGFR ENST00000275493.6 3633 3236 TCGA-02-0010-01 1910840 1799125 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779590 COSM35427 99449865 c.2038C>G p.R680G Substitution - Missense het 38 7:55173101-55173101 + - PATHOGENIC .98466 Variant of unknown origin 329 fresh/frozen - NOS primary 22 ENSP00000275493.2:p.Arg680Gly ENST00000275493.6:c.2038C>G 7:g.55173101C>G EGFR ENST00000275493.6 3633 3236 2675162 2675162 2534436 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51843096 COSM6849768 99379257 c.2246A>T p.E749V Substitution - Missense 38 7:55174783-55174783 + - PATHOGENIC .99468 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000275493.2:p.Glu749Val ENST00000275493.6:c.2246A>T 7:g.55174783A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1094000 1094000 1008702 urinary_tract bladder NS NS carcinoma NS NS NS n COSV51833668 COSM12675 133253212 c.2440G>A p.A814T Substitution - Missense 38 7:55191824-55191824 + - PATHOGENIC .98898 Variant of unknown origin 17707060 surgery fresh/frozen NS ENSP00000415559.1:p.Ala814Thr ENST00000455089.5:c.2440G>A 7:g.55191824G>A EGFR ENST00000275493.6 3633 3236 1592978 1592978 1513904 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51772282 COSM133202 99384247 c.2336G>A p.G779D Substitution - Missense 38 7:55181345-55181345 + - PATHOGENIC .98244 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000275493.2:p.Gly779Asp ENST00000275493.6:c.2336G>A 7:g.55181345G>A EGFR ENST00000275493.6 3633 3236 2344980 2344980 2209652 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1638675 1638675 1554674 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 22321542 surgery-fixed NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1330082 1330082 1240567 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51809790 COSM41665 133208046 c.2366T>C p.V789A Substitution - Missense 38 7:55191750-55191750 + - PATHOGENIC .97813 Variant of unknown origin 20208477 surgery - NOS NS ENSP00000415559.1:p.Val789Ala ENST00000455089.5:c.2366T>C 7:g.55191750T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1113001 1113001 1026509 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51780000 COSM27041 133221412 c.2078T>G p.V693G Substitution - Missense 38 7:55174750-55174750 + - PATHOGENIC .99814 Variant of unknown origin 18302229 surgery - NOS NS 68 ENSP00000415559.1:p.Val693Gly ENST00000455089.5:c.2078T>G 7:g.55174750T>G EGFR ENST00000275493.6 3633 3236 4538 915998 833397 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765668 COSM13198 99380968 c.2596G>A p.E866K Substitution - Missense 38 7:55191845-55191845 + - PATHOGENIC .98912 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000275493.2:p.Glu866Lys ENST00000275493.6:c.2596G>A 7:g.55191845G>A EGFR ENST00000275493.6 3633 3236 1094118 1094118 1008819 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21944 178378514 c.? p.R832H Substitution - Missense + - Variant of unknown origin 18087280 NS NS 66 ENSP00000275493.2:p.Arg832His EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MKN45 983727 899445 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51809237 COSM18445 133206547 c.3008C>T p.A1003V Substitution - Missense het 38 7:55201763-55201763 + - NEUTRAL .41771 Variant of unknown origin 16596188 cell-line NS ENSP00000415559.1:p.Ala1003Val ENST00000455089.5:c.3008C>T 7:g.55201763C>T EGFR ENST00000275493.6 3633 3236 18 2570181 2431478 skin face NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51818444 COSM5991528 99417946 c.2315C>T p.P772L Substitution - Missense 38 7:55181324-55181324 + - PATHOGENIC .97247 Variant of unknown origin 27311873 surgery-fixed NS 53 ENSP00000275493.2:p.Pro772Leu ENST00000275493.6:c.2315C>T 7:g.55181324C>T EGFR ENST00000275493.6 3633 3236 2345001 2345001 2209673 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2345020 2345020 2209692 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2345112 2345112 2209784 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1715893 1715893 1623455 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM250097 178388197 c.? p.F723L Substitution - Missense + - Variant of unknown origin 22760226 surgery - NOS NS 66 EGFR ENST00000275493.6 3633 3236 1162181 1162181 1074513 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780223 COSM28511 99397578 c.2108T>C p.L703P Substitution - Missense 38 7:55173967-55173967 + - PATHOGENIC .90657 Variant of unknown origin 19020901 NS NS ENSP00000275493.2:p.Leu703Pro ENST00000275493.6:c.2108T>C 7:g.55173967T>C EGFR ENST00000275493.6 3633 3236 1477704 1477704 1401403 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51848641 COSM85750 99419414 c.2303_2305delinsTCT p.S768_V769delinsIL Substitution - Missense 38 7:55181312-55181314 + - Variant of unknown origin 21052000 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768_Val769delinsIleLeu ENST00000275493.6:c.2303_2305delinsTCT 7:g.55181312_55181314delinsTCT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1113000 1113000 1026509 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51780000 COSM27041 133221412 c.2078T>G p.V693G Substitution - Missense 38 7:55174750-55174750 + - PATHOGENIC .99814 Variant of unknown origin 18302229 surgery - NOS NS 68 ENSP00000415559.1:p.Val693Gly ENST00000455089.5:c.2078T>G 7:g.55174750T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862095 2862095 2717297 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51799562 COSM6854575 133230120 c.2906A>G p.D969G Substitution - Missense 38 7:55201282-55201282 + - PATHOGENIC .9951 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000415559.1:p.Asp969Gly ENST00000455089.5:c.2906A>G 7:g.55201282A>G EGFR ENST00000275493.6 3633 3236 1964289 1964289 1850824 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1651573 178388466 c.? p.K737G Substitution - Missense + - Variant of unknown origin 23749122 NS NS EGFR ENST00000275493.6 3633 3236 5-GE057-T1 2869770 2724767 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110798 COSM9656412 99458744 c.3079_3080delinsTT p.P1027F Substitution - Missense 38 7:55201320-55201321 + - Variant of unknown origin 26950094 surgery - NOS NS 89 ENSP00000275493.2:p.Pro1027Phe ENST00000275493.6:c.3079_3080delinsTT 7:g.55201320_55201321delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 6367 915989 833388 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51862232 COSM13195 133271765 c.2417T>C p.V806A Substitution - Missense 38 7:55191801-55191801 + - PATHOGENIC .97317 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000415559.1:p.Val806Ala ENST00000455089.5:c.2417T>C 7:g.55191801T>C EGFR ENST00000275493.6 3633 3236 2096194 2096194 1974258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 2156956 2156956 2025931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24828666 fixed - NOS NS 73 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00389T00389 2857373 2712673 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 133232898 c.1027G>A p.D343N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000415559.1:p.Asp343Asn ENST00000455089.5:c.1027G>A 7:g.55156787G>A EGFR ENST00000275493.6 3633 3236 2508973 2508973 2371308 central_nervous_system temporal_lobe NS NS glioma oligoastrocytoma_Grade_II NS NS n COSV51823792 COSM5762244 99460292 c.2884C>T p.R962C Substitution - Missense 38 7:55200351-55200351 + - PATHOGENIC .96304 Variant of unknown origin 26919320 surgery - NOS NS 32 ENSP00000275493.2:p.Arg962Cys ENST00000275493.6:c.2884C>T 7:g.55200351C>T EGFR ENST00000275493.6 3633 3236 1729731 1729731 1635702 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM255169 178381173 c.? p.R705K Substitution - Missense + - Variant of unknown origin 22805266 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P13_20580_7_S4_R1_001 2823451 2679304 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51846371 COSM7338932 133253849 c.2783G>A p.R928Q Substitution - Missense 38 7:55200385-55200385 + - PATHOGENIC .99379 Variant of unknown origin 31854063 surgery fresh/frozen primary 61 ENSP00000415559.1:p.Arg928Gln ENST00000455089.5:c.2783G>A 7:g.55200385G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-D48943 2905181 2759437 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864603 COSM9999789 133275596 c.2689G>A p.D897N Substitution - Missense 38 7:55198839-55198839 + - PATHOGENIC .9854 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000415559.1:p.Asp897Asn ENST00000455089.5:c.2689G>A 7:g.55198839G>A EGFR ENST00000275493.6 3633 3236 1484364 1484364 1407990 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSM85906 178388908 c.? p.L782P Substitution - Missense + - Variant of unknown origin 21266046 surgery-fixed primary 70 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1179043 1179043 1091005 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51813062 COSM12764 133203122 c.2434G>A p.G812R Substitution - Missense het 38 7:55191818-55191818 + - PATHOGENIC .98898 Variant of unknown origin 19190079 surgery-fixed primary 52 ENSP00000415559.1:p.Gly812Arg ENST00000455089.5:c.2434G>A 7:g.55191818G>A EGFR ENST00000275493.6 3633 3236 1043868 1043868 960209 lung NS NS NS carcinoma spindle_cell_carcinoma NS NS n COSV51770611 COSM22993 99430319 c.2162G>A p.G721D Substitution - Missense 38 7:55174021-55174021 + - PATHOGENIC .98289 Variant of unknown origin 17192902 NS NS ENSP00000275493.2:p.Gly721Asp ENST00000275493.6:c.2162G>A 7:g.55174021G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778595 2778595 2636649 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV99294037 COSM7410343 132570039 c.2486G>A p.G829D Substitution - Missense 38 7:55191870-55191870 + - PATHOGENIC .98912 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000395243.3:p.Gly829Asp ENST00000454757.6:c.2486G>A 7:g.55191870G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-B0-5713-01 1779868 1683867 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51801505 COSM485464 133279566 c.2279A>G p.H760R Substitution - Missense hom 38 7:55181423-55181423 + - PATHOGENIC .97392 Variant of unknown origin 416 fresh/frozen - NOS primary 75 ENSP00000415559.1:p.His760Arg ENST00000455089.5:c.2279A>G 7:g.55181423A>G EGFR ENST00000275493.6 3633 3236 1162968 1162968 1075291 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM28554 178387186 c.? p.G796A Substitution - Missense + - Variant of unknown origin 18992959 NS recurrent 71 ENSP00000275493.2:p.Gly796Ala EGFR ENST00000275493.6 3633 3236 2264366 2264366 2131350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR ENST00000275493.6 3633 3236 2345035 2345035 2209707 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2264360 2264360 2131344 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR ENST00000275493.6 3633 3236 2240554 2240554 2108085 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25227801 surgery-fixed NS EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2733214 2733214 2591967 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827210 COSM7002282 132549473 c.3350G>A p.S1117N Substitution - Missense 38 7:55205469-55205469 + - NEUTRAL .08134 Variant of unknown origin 28855349 surgery - NOS recurrent 55 ENSP00000395243.3:p.Ser1117Asn ENST00000454757.6:c.3350G>A 7:g.55205469G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-22-4601-01 1780882 1684881 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51789475 COSM747423 133248239 c.2921C>T p.P974L Substitution - Missense 38 7:55201297-55201297 + - PATHOGENIC .99234 Variant of unknown origin 418 fresh/frozen - NOS primary 73 ENSP00000415559.1:p.Pro974Leu ENST00000455089.5:c.2921C>T 7:g.55201297C>T EGFR ENST00000275493.6 3633 3236 2344995 2344995 2209667 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2062141 2062141 1942220 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51850053 COSM1717823 99403281 c.2585T>G p.L862R Substitution - Missense het 38 7:55191834-55191834 + - PATHOGENIC .98155 Variant of unknown origin 24279718 surgery-fixed recurrent 61 ENSP00000275493.2:p.Leu862Arg ENST00000275493.6:c.2585T>G 7:g.55191834T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862107 2862107 2717309 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV105111081 COSM9572577 132557359 c.1318G>A p.G440S Substitution - Missense 38 7:55160293-55160293 + - NEUTRAL .00282 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000395243.3:p.Gly440Ser ENST00000454757.6:c.1318G>A 7:g.55160293G>A EGFR ENST00000275493.6 3633 3236 19 2570191 2431488 skin face NS NS adnexal_tumour other sebaceoma NS n COSV51828195 COSM13180 99405775 c.2188C>T p.L730F Substitution - Missense 38 7:55174725-55174725 + - PATHOGENIC .96849 Variant of unknown origin 27311873 surgery-fixed NS 71 ENSP00000275493.2:p.Leu730Phe ENST00000275493.6:c.2188C>T 7:g.55174725C>T EGFR ENST00000275493.6 3633 3236 3696 915973 833372 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51828195 COSM13180 99405775 c.2188C>T p.L730F Substitution - Missense 38 7:55174725-55174725 + - PATHOGENIC .96849 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000275493.2:p.Leu730Phe ENST00000275493.6:c.2188C>T 7:g.55174725C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2840810 2840810 2696370 prostate NS NS NS carcinoma NS NS NS n COSV104577207 COSM9493802 132621838 c.551G>A p.S184N Substitution - Missense 38 7:55152603-55152603 + - PATHOGENIC .9474 Variant of unknown origin 31874108 surgery-fixed metastasis ENSP00000395243.3:p.Ser184Asn ENST00000454757.6:c.551G>A 7:g.55152603G>A EGFR ENST00000275493.6 3633 3236 2617800 2617800 2478284 skin NS NS NS carcinoma squamous_cell_carcinoma_BRAF_inhibitor_related NS NS n COSM34155 178380594 c.? p.V769M Substitution - Missense + - Variant of unknown origin 25724524 surgery-fixed NS 61 ENSP00000275493.2:p.Val769Met EGFR ENST00000275493.6 3633 3236 1996569 1996569 1881778 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM34155 178380594 c.? p.V769M Substitution - Missense + - Variant of unknown origin 23922984 surgery-fixed NS ENSP00000275493.2:p.Val769Met EGFR ENST00000275493.6 3633 3236 1014269 1014269 931443 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20894 178379162 c.? p.A859T Substitution - Missense het + - Variant of unknown origin 16931592 fixed - NOS NS ENSP00000275493.2:p.Ala859Thr EGFR ENST00000275493.6 3633 3236 2083107 2083107 1961528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1666915 178387431 c.? p.L833F Substitution - Missense + - Variant of unknown origin 24300726 surgery-fixed NS ENSP00000275493.2:p.Leu833Phe EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-D1-A15W-01 1783496 1687495 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51815247 COSM1090893 132549888 c.2615G>C p.G872A Substitution - Missense hom 38 7:55198765-55198765 + - PATHOGENIC .98646 Variant of unknown origin 419 fresh/frozen - NOS primary 58 ENSP00000395243.3:p.Gly872Ala ENST00000454757.6:c.2615G>C 7:g.55198765G>C EGFR ENST00000275493.6 3633 3236 2908039 2908039 2762219 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM10045248 178382394 c.? p.L833_V834delinsFL Substitution - Missense + - Variant of unknown origin 24457237 surgery-fixed NS 62 ENSP00000275493.2:p.Leu833_Val834delinsPheLeu EGFR ENST00000275493.6 3633 3236 1043873 1043873 960214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51770642 COSM22992 99380893 c.2161G>A p.G721S Substitution - Missense 38 7:55174020-55174020 + - PATHOGENIC .98289 Variant of unknown origin 17192902 NS NS ENSP00000275493.2:p.Gly721Ser ENST00000275493.6:c.2161G>A 7:g.55174020G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-GE067-T1 2869773 2724770 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51802062 COSM6008937 132557741 c.524C>T p.S175F Substitution - Missense 38 7:55152576-55152576 + - PATHOGENIC .98424 Variant of unknown origin 26950094 surgery - NOS NS ENSP00000395243.3:p.Ser175Phe ENST00000454757.6:c.524C>T 7:g.55152576C>T EGFR ENST00000275493.6 3633 3236 MG-144-tumor 2819049 2675348 meninges NS NS NS meningioma atypical NS NS n COSV104369075 COSM9267309 99402941 c.1816C>G p.L606V Substitution - Missense 38 7:55165373-55165373 + - PATHOGENIC .90295 Variant of unknown origin 28713588 surgery - NOS NS ENSP00000275493.2:p.Leu606Val ENST00000275493.6:c.1816C>G 7:g.55165373C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732917 2732917 2591670 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827197 COSM7002281 133249478 c.1649G>A p.C550Y Substitution - Missense 38 7:55165341-55165341 + - PATHOGENIC .99683 Variant of unknown origin 28855349 surgery - NOS primary 39 ENSP00000415559.1:p.Cys550Tyr ENST00000455089.5:c.1649G>A 7:g.55165341G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1179042 1179042 1091004 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51848529 COSM28929 132598439 c.2033T>C p.F678S Substitution - Missense het 38 7:55174027-55174027 + - PATHOGENIC .97491 Variant of unknown origin 19190079 surgery-fixed primary 54 ENSP00000395243.3:p.Phe678Ser ENST00000454757.6:c.2033T>C 7:g.55174027T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1517073 1517073 1439667 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51835762 COSM88211 132601053 c.2414A>G p.H805R Substitution - Missense het 38 7:55191798-55191798 + - PATHOGENIC .9858 Variant of unknown origin 21592614 surgery-fixed NS 57 ENSP00000395243.3:p.His805Arg ENST00000454757.6:c.2414A>G 7:g.55191798A>G EGFR ENST00000275493.6 3633 3236 2083100 2083100 1961521 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM1651578 178380642 c.? p.K714N Substitution - Missense + - Variant of unknown origin 24300726 surgery-fixed NS ENSP00000275493.2:p.Lys714Asn EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2026223 2026223 1908312 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51817197 COSM1716258 133257188 c.2468A>T p.E823V Substitution - Missense het 38 7:55191852-55191852 + - PATHOGENIC .96496 Variant of unknown origin 24040454 surgery-fixed NS ENSP00000415559.1:p.Glu823Val ENST00000455089.5:c.2468A>T 7:g.55191852A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2841802 2841802 2697351 soft_tissue fibrous_tissue_and_uncertain_origin NS NS desmoid_tumour-fibromatosis NS NS NS n COSV104576751 COSM9414780 133239823 c.3052G>A p.D1018N Substitution - Missense 38 7:55202541-55202541 + - PATHOGENIC .93865 Variant of unknown origin 32099073 surgery-fixed NS ENSP00000415559.1:p.Asp1018Asn ENST00000455089.5:c.3052G>A 7:g.55202541G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5330 915979 833378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51861323 COSM13187 133282284 c.2413C>A p.H805N Substitution - Missense 38 7:55191797-55191797 + - PATHOGENIC .98386 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000415559.1:p.His805Asn ENST00000455089.5:c.2413C>A 7:g.55191797C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD36792a 2894864 2749352 skin head_neck NS NS malignant_melanoma NS NS NS y COSV105110843 COSM9876432 132547899 c.3494C>T p.A1165V Substitution - Missense 38 7:55205613-55205613 + - PATHOGENIC .9319 Variant of unknown origin 33024263 surgery-fixed metastasis 72 ENSP00000395243.3:p.Ala1165Val ENST00000454757.6:c.3494C>T 7:g.55205613C>T EGFR ENST00000275493.6 3633 3236 2008791 2008791 1891525 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083100 2083100 1961521 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM1737970 178386479 c.? p.V717E Substitution - Missense + - Variant of unknown origin 24300726 surgery-fixed NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668455 1668455 1581748 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51783814 COSM219793 133261196 c.2463G>T p.E821D Substitution - Missense 38 7:55191847-55191847 + - PATHOGENIC .94716 Variant of unknown origin 22523180 surgery - NOS NS ENSP00000415559.1:p.Glu821Asp ENST00000455089.5:c.2463G>T 7:g.55191847G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625561 2625561 2485973 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 132553412 c.2477C>G p.A826G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 27056568 surgery-fixed NS 51 ENSP00000395243.3:p.Ala826Gly ENST00000454757.6:c.2477C>G 7:g.55191861C>G EGFR ENST00000275493.6 3633 3236 1014119 1014119 931293 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770686 1770686 1674926 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879493 1879493 1769995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1032006 1032006 948797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17060940 pleural effusion NS 65 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2118428 2118428 1992663 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1077332 1077332 992586 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302280 1302280 1213331 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1892645 1892645 1781897 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23566546 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098881 1098881 1013473 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773148 COSM26435 132608545 c.2132A>G p.N711S Substitution - Missense 38 7:55174804-55174804 + - PATHOGENIC .9946 Variant of unknown origin 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Asn711Ser ENST00000454757.6:c.2132A>G 7:g.55174804A>G EGFR ENST00000275493.6 3633 3236 1875151 1875151 1765742 thymus NS NS NS thymic_carcinoma NS NS NS n COSM23617 178385408 c.? p.T785I Substitution - Missense + - Reported in another cancer sample as somatic 23139256 fixed - NOS NS ENSP00000275493.2:p.Thr785Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DM26 2466862 2329693 skin scalp NS NS malignant_melanoma desmoplastic NS NS n COSV51820811 COSM5611257 133258423 c.1653_1654delinsAA p.A552T Substitution - Missense 38 7:55165345-55165346 + - Variant of unknown origin 26343386 surgery-fixed NS 79 ENSP00000415559.1:p.Ala552Thr ENST00000455089.5:c.1653_1654delinsAA 7:g.55165345_55165346delinsAA EGFR ENST00000275493.6 3633 3236 1593031 1593031 1513957 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51776171 COSM28605 99430754 c.2611G>A p.A871T Substitution - Missense 38 7:55191860-55191860 + - PATHOGENIC .9853 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000275493.2:p.Ala871Thr ENST00000275493.6:c.2611G>A 7:g.55191860G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194724 1194724 1106619 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849762 COSM29340 132618507 c.683C>A p.T228N Substitution - Missense 38 7:55154081-55154081 + - PATHOGENIC .90357 Variant of unknown origin 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Thr228Asn ENST00000454757.6:c.683C>A 7:g.55154081C>A EGFR ENST00000275493.6 3633 3236 1921950 1921950 1809268 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665709 2665709 2525418 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS primary 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1043864 1043864 960205 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2905783 2905783 2760035 meninges NS NS NS meningioma NS NS NS n COSM5352244 178383832 c.? p.G810D Substitution - Missense + - Variant of unknown origin 31872418 surgery - NOS NS ENSP00000275493.2:p.Gly810Asp EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659760 2659760 2519918 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766584 COSM12371 133211112 c.1991A>T p.E664V Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97538 Variant of unknown origin 28744312 surgery-fixed NS ENSP00000415559.1:p.Glu664Val ENST00000455089.5:c.1991A>T 7:g.55173985A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000030-T01-IM3 2714482 2573303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51789972 COSM6985979 132564710 c.768_771delinsACAC p.T257H Substitution - Missense het 38 7:55155843-55155846 + - Variant of unknown origin 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr257His ENST00000454757.6:c.768_771delinsACAC 7:g.55155843_55155846delinsACAC EGFR ENST00000275493.6 3633 3236 1668675 1668675 1581967 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM27104 178383972 c.? p.H850D Substitution - Missense + - Variant of unknown origin 22523351 fixed - NOS NS ENSP00000275493.2:p.His850Asp EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LAPC4 2580299 2441636 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51777967 COSM6005629 132588349 c.2804T>A p.V935D Substitution - Missense 38 7:55200406-55200406 + - PATHOGENIC .98972 Variant of unknown origin 20579941 xenograft NS ENSP00000395243.3:p.Val935Asp ENST00000454757.6:c.2804T>A 7:g.55200406T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1517065 1517065 1439659 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51785962 COSM88212 132608658 c.2125_2126delinsGC p.K709A Substitution - Missense het 38 7:55174797-55174798 + - Variant of unknown origin 21592614 surgery-fixed NS 45 ENSP00000395243.3:p.Lys709Ala ENST00000454757.6:c.2125_2126delinsGC 7:g.55174797_55174798delinsGC EGFR ENST00000275493.6 3633 3236 2732917 2732917 2591670 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827197 COSM7002281 99425372 c.1784G>A p.C595Y Substitution - Missense 38 7:55165341-55165341 + - PATHOGENIC .99683 Variant of unknown origin 28855349 surgery - NOS primary 39 ENSP00000275493.2:p.Cys595Tyr ENST00000275493.6:c.1784G>A 7:g.55165341G>A EGFR ENST00000275493.6 3633 3236 1996551 1996551 1881760 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1666917 178385443 c.? p.K708N Substitution - Missense + - Variant of unknown origin 23922984 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1465902 1465902 1389749 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 73 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1465902 1465902 1389749 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1531005 1531005 1453377 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1707038 1707038 1614944 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22695392 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469803 1469803 1393542 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1887390 1887390 1777062 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1456580 1456580 1380555 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1637106 1637106 1553154 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2579677 2579677 2441014 NS NS NS NS malignant_melanoma NS NS NS n COSV51804547 COSM6005741 133234430 c.2163G>A p.M721I Substitution - Missense 38 7:55181307-55181307 + - PATHOGENIC .98539 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000415559.1:p.Met721Ile ENST00000455089.5:c.2163G>A 7:g.55181307G>A EGFR ENST00000275493.6 3633 3236 1074909 1074909 990163 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM24847 178389078 c.? p.I715L Substitution - Missense + - Variant of unknown origin 17508947 surgery fresh/frozen primary 58 EGFR ENST00000275493.6 3633 3236 2118474 2118474 1992709 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24568474 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2345118 2345118 2209790 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1594552 1594552 1515520 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772314 COSM27568 99378866 c.2387G>C p.G796A Substitution - Missense 38 7:55181396-55181396 + - PATHOGENIC .95257 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000275493.2:p.Gly796Ala ENST00000275493.6:c.2387G>C 7:g.55181396G>C EGFR ENST00000275493.6 3633 3236 LPS3 2800446 2657262 soft_tissue fat NS NS liposarcoma well_differentiated NS NS n COSV99289299 COSM9110946 99418439 c.1249C>T p.L417F Substitution - Missense 38 7:55157704-55157704 + - PATHOGENIC .98762 Variant of unknown origin 26643872 surgery - NOS primary ENSP00000275493.2:p.Leu417Phe ENST00000275493.6:c.1249C>T 7:g.55157704C>T EGFR ENST00000275493.6 3633 3236 2873717 2873717 2728710 pancreas NS NS NS other dysplasia-in_situ_neoplasm NS NS n COSM28619 178383742 c.? p.V786M Substitution - Missense + - Variant of unknown origin 32792597 fine needle aspirate NS 71 ENSP00000275493.2:p.Val786Met EGFR ENST00000275493.6 3633 3236 MYL-017 2672913 2532432 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS n COSM6848495 178386138 c.? p.A1201T Substitution - Missense + - Variant of unknown origin 28492226 circulating tumour NS ENSP00000275493.2:p.Ala1201Thr EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593032 1593032 1513958 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51774247 COSM13008 132553412 c.2477C>G p.A826G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000395243.3:p.Ala826Gly ENST00000454757.6:c.2477C>G 7:g.55191861C>G EGFR ENST00000275493.6 3633 3236 1435972 1435972 1345251 lung left_lower_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20439191 surgery fresh/frozen NS 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027351 2027351 1909419 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 40 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1112973 1112973 1026484 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448997 surgery-fixed NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469852 1469852 1393591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469852 1469852 1393591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875378 1875378 1765961 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1047874 1047874 964103 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 17228019 surgery - NOS NS 73 ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 4538 915998 833397 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765668 COSM13198 133209210 c.2461G>A p.E821K Substitution - Missense 38 7:55191845-55191845 + - PATHOGENIC .98912 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000415559.1:p.Glu821Lys ENST00000455089.5:c.2461G>A 7:g.55191845G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043132 1043132 959473 upper_aerodigestive_tract tonsil NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51798093 COSM22952 132615020 c.2303A>G p.Y768C Substitution - Missense 38 7:55181447-55181447 + - PATHOGENIC .90224 Variant of unknown origin 17224267 surgery-fixed NS 49 ENSP00000395243.3:p.Tyr768Cys ENST00000454757.6:c.2303A>G 7:g.55181447A>G EGFR ENST00000275493.6 3633 3236 2675408 2675408 2534682 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675163 2675163 2534437 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51797702 COSM6849769 133238724 c.2099A>C p.K700T Substitution - Missense 38 7:55174771-55174771 + - PATHOGENIC .99622 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000415559.1:p.Lys700Thr ENST00000455089.5:c.2099A>C 7:g.55174771A>C EGFR ENST00000275493.6 3633 3236 1471798 1471798 1395536 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51798278 COSM53224 99433199 c.2173A>G p.T725A Substitution - Missense 38 7:55174032-55174032 + - PATHOGENIC .98345 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000275493.2:p.Thr725Ala ENST00000275493.6:c.2173A>G 7:g.55174032A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-24-1850-01 1731201 1637167 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51792742 COSM1330578 132615992 c.648G>T p.K216N Substitution - Missense het 38 7:55154046-55154046 + - PATHOGENIC .96256 Variant of unknown origin 331 NS primary 72 ENSP00000395243.3:p.Lys216Asn ENST00000454757.6:c.648G>T 7:g.55154046G>T EGFR ENST00000275493.6 3633 3236 1165593 1165593 1077907 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM28574 178384302 c.? p.P848L Substitution - Missense + - Reported in another cancer sample as somatic 19050706 surgery fresh/frozen NS ENSP00000275493.2:p.Pro848Leu EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-144-tumor 2819049 2675348 meninges NS NS NS meningioma atypical NS NS n COSV104369075 COSM9267309 133228672 c.1681C>G p.L561V Substitution - Missense 38 7:55165373-55165373 + - PATHOGENIC .90295 Variant of unknown origin 28713588 surgery - NOS NS ENSP00000415559.1:p.Leu561Val ENST00000455089.5:c.1681C>G 7:g.55165373C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675162 2675162 2534436 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51843096 COSM6849768 133207405 c.2111A>T p.E704V Substitution - Missense 38 7:55174783-55174783 + - PATHOGENIC .99468 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000415559.1:p.Glu704Val ENST00000455089.5:c.2111A>T 7:g.55174783A>T EGFR ENST00000275493.6 3633 3236 1667723 1667723 1581016 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM219792 178384400 c.? p.D855N Substitution - Missense + - Variant of unknown origin 22528563 NS NS ENSP00000275493.2:p.Asp855Asn EGFR ENST00000275493.6 3633 3236 1875152 1875152 1765743 soft_tissue NS NS NS sarcoma NS NS NS n COSM34155 178380594 c.? p.V769M Substitution - Missense + - Variant of unknown origin 23139256 fixed - NOS NS ENSP00000275493.2:p.Val769Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778590 2778590 2636644 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV99296732 COSM7410339 133238819 c.2317T>C p.C773R Substitution - Missense 38 7:55181461-55181461 + - PATHOGENIC .95365 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000415559.1:p.Cys773Arg ENST00000455089.5:c.2317T>C 7:g.55181461T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC20 2439238 2302079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51781350 COSM5369838 132569921 c.407C>G p.P136R Substitution - Missense 38 7:55143471-55143471 + - PATHOGENIC .90708 Variant of unknown origin 26164066 surgery-fixed metastasis ENSP00000395243.3:p.Pro136Arg ENST00000454757.6:c.407C>G 7:g.55143471C>G EGFR ENST00000275493.6 3633 3236 1937505 1937505 1824439 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214538 2214538 2082662 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174333 1174333 1086352 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083798 1083798 998963 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011166 2011166 1893804 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1815284 1815284 1714455 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22896669 surgery - NOS recurrent 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2686009 2686009 2545044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2009143 2009143 1891877 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1475380 1475380 1399079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2582955 2582955 2444209 lung right_lower_lobe NS NS carcinoma adenocarcinoma transformed_to_small_cell_carcinoma NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28031840 surgery - NOS recurrent 70 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1624154 1624154 1541741 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22000696 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2651878 2651878 2512016 NS NS NS NS malignant_melanoma NS NS NS n COSV51778029 COSM6268 99381060 c.2257C>T p.P753S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 24336498 xenograft NS ENSP00000275493.2:p.Pro753Ser ENST00000275493.6:c.2257C>T 7:g.55174794C>T EGFR ENST00000275493.6 3633 3236 1602600 1602600 1521936 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 22082647 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 PC-9-GR-step 1896428 1785118 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23542356 cell-line NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879541 1879541 1770043 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1424046 1424046 1334074 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20595147 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1102422 1102422 1016674 lung right_upper_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18208799 surgery-fixed primary 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444735 1444735 1368978 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264282 2264282 2131266 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1500177 1500177 1423056 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042857 1042857 959198 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51852379 COSM22942 132567403 c.2200G>T p.G734C Substitution - Missense 38 7:55181344-55181344 + - PATHOGENIC .98402 Variant of unknown origin 17285735 surgery - NOS NS ENSP00000395243.3:p.Gly734Cys ENST00000454757.6:c.2200G>T 7:g.55181344G>T EGFR ENST00000275493.6 3633 3236 2000066 2000066 1884964 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106562 2106562 1984425 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425734 2425734 2288655 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264364 2264364 2131348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR ENST00000275493.6 3633 3236 2096191 2096191 1974255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 1053136 1053136 969207 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17409961 surgery - NOS NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1453497 1453497 1377530 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1094002 1094002 1008704 urinary_tract bladder NS NS carcinoma NS NS NS n COSV51789830 COSM26035 133212590 c.2456C>A p.A819E Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .95798 Variant of unknown origin 17707060 surgery fresh/frozen NS ENSP00000415559.1:p.Ala819Glu ENST00000455089.5:c.2456C>A 7:g.55191840C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LS411 2301999 2167282 large_intestine colon right NS carcinoma adenocarcinoma NS NS y COSV51794338 COSM3266643 132586487 c.2683A>G p.T895A Substitution - Missense het 38 7:55198833-55198833 + - PATHOGENIC .97948 Variant of unknown origin 24755471 cell-line NS ENSP00000395243.3:p.Thr895Ala ENST00000454757.6:c.2683A>G 7:g.55198833A>G EGFR ENST00000275493.6 3633 3236 2245044 2245044 2112320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014120 1014120 931294 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1047956 1047956 964184 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM23615 178387435 c.? p.K713F Substitution - Missense + - Variant of unknown origin 17337084 surgery-fixed NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2508973 2508973 2371308 central_nervous_system temporal_lobe NS NS glioma oligoastrocytoma_Grade_II NS NS n COSV51823792 COSM5762244 133284961 c.2749C>T p.R917C Substitution - Missense 38 7:55200351-55200351 + - PATHOGENIC .96304 Variant of unknown origin 26919320 surgery - NOS NS 32 ENSP00000415559.1:p.Arg917Cys ENST00000455089.5:c.2749C>T 7:g.55200351C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594551 1594551 1515519 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51776191 COSM133565 132559384 c.2252G>A p.G751D Substitution - Missense 38 7:55181396-55181396 + - PATHOGENIC .96481 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000395243.3:p.Gly751Asp ENST00000454757.6:c.2252G>A 7:g.55181396G>A EGFR ENST00000275493.6 3633 3236 2344984 2344984 2209656 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2167082 2167082 2035396 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51782791 COSM3736992 99376755 c.2306T>C p.V769A Substitution - Missense het 38 7:55181315-55181315 + - PATHOGENIC .97686 Variant of unknown origin 24908064 surgery - NOS NS 58 ENSP00000275493.2:p.Val769Ala ENST00000275493.6:c.2306T>C 7:g.55181315T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 UCHRP3 2682242 2541515 large_intestine NS NS NS other ulcerative_colitis dysplasia NS n COSV51844380 COSM6854567 132568033 c.721A>G p.S241G Substitution - Missense 38 7:55154119-55154119 + - PATHOGENIC .99273 Variant of unknown origin 28524162 surgery fresh/frozen NS 54 ENSP00000395243.3:p.Ser241Gly ENST00000454757.6:c.721A>G 7:g.55154119A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 UCHRP3 2682242 2541515 large_intestine NS NS NS other ulcerative_colitis dysplasia NS n COSV51844399 COSM6854571 132568037 c.1674C>A p.N558K Substitution - Missense 38 7:55165366-55165366 + - PATHOGENIC .87723 Variant of unknown origin 28524162 surgery fresh/frozen NS 54 ENSP00000395243.3:p.Asn558Lys ENST00000454757.6:c.1674C>A 7:g.55165366C>A EGFR ENST00000275493.6 3633 3236 2233653 2233653 2101236 skin NS NS NS malignant_melanoma NS NS NS n COSM4172522 178386505 c.? p.R255Q Substitution - Missense + - Variant of unknown origin 24628946 surgery fresh/frozen NS 38 ENSP00000275493.2:p.Arg255Gln EGFR ENST00000275493.6 3633 3236 1047962 1047962 964190 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM23616 178382710 c.? p.L799R Substitution - Missense + - Variant of unknown origin 17337084 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2579643 2579643 2440980 NS NS NS NS malignant_melanoma NS NS NS n COSV51815916 COSM28600 99393685 c.2095C>T p.P699S Substitution - Missense 38 7:55173954-55173954 + - PATHOGENIC .97389 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000275493.2:p.Pro699Ser ENST00000275493.6:c.2095C>T 7:g.55173954C>T EGFR ENST00000275493.6 3633 3236 1166430 1166430 1078744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773237 COSM28609 99411858 c.2416A>G p.K806E Substitution - Missense het 38 7:55181425-55181425 + - PATHOGENIC .9712 Variant of unknown origin 16870303 surgery - NOS NS 51 ENSP00000275493.2:p.Lys806Glu ENST00000275493.6:c.2416A>G 7:g.55181425A>G EGFR ENST00000275493.6 3633 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV104577168 COSM9361242 99453384 c.2384T>G p.F795C Substitution - Missense het 38 7:55181393-55181393 + - PATHOGENIC .74752 Variant of unknown origin 31632838 circulating tumour recurrent 68 ENSP00000275493.2:p.Phe795Cys ENST00000275493.6:c.2384T>G 7:g.55181393T>G EGFR ENST00000275493.6 3633 3236 1043870 1043870 960211 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51787381 COSM22991 99413046 c.2330T>A p.L777Q Substitution - Missense 38 7:55181339-55181339 + - PATHOGENIC .97894 Variant of unknown origin 17192902 NS NS ENSP00000275493.2:p.Leu777Gln ENST00000275493.6:c.2330T>A 7:g.55181339T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732935 2732935 2591688 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51771844 COSM7002278 132558352 c.2806A>C p.I936L Substitution - Missense 38 7:55200408-55200408 + - PATHOGENIC .99358 Variant of unknown origin 28855349 surgery - NOS recurrent 72 ENSP00000395243.3:p.Ile936Leu ENST00000454757.6:c.2806A>C 7:g.55200408A>C EGFR ENST00000275493.6 3633 3236 2226854 2226854 2094589 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51787381 COSM22991 99413046 c.2330T>A p.L777Q Substitution - Missense 38 7:55181339-55181339 + - PATHOGENIC .97894 Variant of unknown origin 24891042 NS NS ENSP00000275493.2:p.Leu777Gln ENST00000275493.6:c.2330T>A 7:g.55181339T>A EGFR ENST00000275493.6 3633 3236 1661390 1661390 1575005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51799102 COSM28513 99387223 c.2350T>C p.S784P Substitution - Missense 38 7:55181359-55181359 + - PATHOGENIC .95834 Variant of unknown origin 22483783 surgery-fixed NS 57 ENSP00000275493.2:p.Ser784Pro ENST00000275493.6:c.2350T>C 7:g.55181359T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862120 2862120 2717322 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV105110976 COSM9572578 132557363 c.1496G>A p.G499D Substitution - Missense 38 7:55161631-55161631 + - PATHOGENIC .99386 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000395243.3:p.Gly499Asp ENST00000454757.6:c.1496G>A 7:g.55161631G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1517063 1517063 1439657 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51777270 COSM88213 132593965 c.2284G>A p.D762N Substitution - Missense 38 7:55181428-55181428 + - PATHOGENIC .95157 Variant of unknown origin 21592614 surgery-fixed NS 54 ENSP00000395243.3:p.Asp762Asn ENST00000454757.6:c.2284G>A 7:g.55181428G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 34 2760142 2618675 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51797913 COSM7339051 132556491 c.2370C>A p.H790Q Substitution - Missense 38 7:55191754-55191754 + - PATHOGENIC .83351 Variant of unknown origin 29876005 surgery-fixed NS ENSP00000395243.3:p.His790Gln ENST00000454757.6:c.2370C>A 7:g.55191754C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SUPT1 1760532 1665135 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51819830 COSM327147 132560706 c.617G>A p.C206Y Substitution - Missense 38 7:55154015-55154015 + - PATHOGENIC .98182 Variant of unknown origin 22675565 cell-line NS ENSP00000395243.3:p.Cys206Tyr ENST00000454757.6:c.617G>A 7:g.55154015G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2626094 2626094 2486506 lung NS NS NS carcinoid-endocrine_tumour atypical NS NS n COSV51823853 COSM6191491 133202255 c.311T>A p.L104Q Substitution - Missense hom 38 7:55143375-55143375 + - PATHOGENIC .99116 Variant of unknown origin 26645239 surgery-fixed NS ENSP00000415559.1:p.Leu104Gln ENST00000455089.5:c.311T>A 7:g.55143375T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1705345 1705345 1613329 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51769837 COSM249780 133215601 c.2275G>A p.E759K Substitution - Missense 38 7:55181419-55181419 + - PATHOGENIC .97109 Variant of unknown origin 22722798 surgery - NOS recurrent 71 ENSP00000415559.1:p.Glu759Lys ENST00000455089.5:c.2275G>A 7:g.55181419G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2579643 2579643 2440980 NS NS NS NS malignant_melanoma NS NS NS n COSV51815916 COSM28600 133220795 c.1960C>T p.P654S Substitution - Missense 38 7:55173954-55173954 + - PATHOGENIC .97389 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000415559.1:p.Pro654Ser ENST00000455089.5:c.1960C>T 7:g.55173954C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-55-7570-01 1914018 1802300 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51813309 COSM6178064 132607524 c.763G>A p.V255M Substitution - Missense 38 7:55155838-55155838 + - PATHOGENIC .97875 Variant of unknown origin 417 fresh/frozen - NOS primary 60 ENSP00000395243.3:p.Val255Met ENST00000454757.6:c.763G>A 7:g.55155838G>A EGFR ENST00000275493.6 3633 3236 1098882 1098882 1013474 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51835641 COSM26436 99451782 c.2534T>C p.V845A Substitution - Missense 38 7:55191783-55191783 + - PATHOGENIC .97813 Variant of unknown origin 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Val845Ala ENST00000275493.6:c.2534T>C 7:g.55191783T>C EGFR ENST00000275493.6 3633 3236 1230485 1230485 1142299 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM30757 178389361 c.? p.E758G Substitution - Missense + - Variant of unknown origin 19536777 NS NS ENSP00000275493.2:p.Glu758Gly EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-18-J14363 2905547 2759803 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864624 COSM10000827 132607821 c.2911T>A p.Y971N Substitution - Missense 38 7:55201287-55201287 + - PATHOGENIC .99264 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000395243.3:p.Tyr971Asn ENST00000454757.6:c.2911T>A 7:g.55201287T>A EGFR ENST00000275493.6 3633 3236 2595751 2595751 2456627 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 27538584 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1966339 1966339 1852832 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 23787800 surgery - NOS NS EGFR ENST00000275493.6 3633 3236 2345107 2345107 2209779 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2106485 2106485 1984348 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24575772 surgery - NOS NS 51 EGFR ENST00000275493.6 3633 3236 2264368 2264368 2131352 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1179043 1179043 1091005 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51818061 COSM28930 133203114 c.2219C>A p.T740N Substitution - Missense hom 38 7:55181363-55181363 + - PATHOGENIC .95016 Variant of unknown origin 19190079 surgery-fixed primary 52 ENSP00000415559.1:p.Thr740Asn ENST00000455089.5:c.2219C>A 7:g.55181363C>A EGFR ENST00000275493.6 3633 3236 2345015 2345015 2209687 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV104577168 COSM9361242 133277192 c.2249T>G p.F750C Substitution - Missense het 38 7:55181393-55181393 + - PATHOGENIC .74752 Variant of unknown origin 31632838 circulating tumour recurrent 68 ENSP00000415559.1:p.Phe750Cys ENST00000455089.5:c.2249T>G 7:g.55181393T>G EGFR ENST00000275493.6 3633 3236 1196963 1196963 1108858 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM29379 178388900 c.? p.E829Q Substitution - Missense + - Variant of unknown origin 19289583 surgery - NOS primary EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479924 1479924 1403584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766584 COSM12371 132555223 c.1991A>T p.E664V Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97538 Variant of unknown origin 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Glu664Val ENST00000454757.6:c.1991A>T 7:g.55173985A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659760 2659760 2519918 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51771654 COSM6506512 133219281 c.2005A>G p.K669E Substitution - Missense 38 7:55173999-55173999 + - PATHOGENIC .9657 Variant of unknown origin 28744312 surgery-fixed NS ENSP00000415559.1:p.Lys669Glu ENST00000455089.5:c.2005A>G 7:g.55173999A>G EGFR ENST00000275493.6 3633 3236 2603438 2603438 2464329 central_nervous_system brain NS NS glioma oligoastrocytoma_Grade_III anaplastic NS n COSM6024086 178382369 c.? p.V550M Substitution - Missense + - Variant of unknown origin 28042970 surgery-fixed NS 55 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00243T00243 2857340 2712640 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105111181 COSM9542450 133232875 c.61G>A p.A21T Substitution - Missense 38 7:55019338-55019338 + - NEUTRAL .06121 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000415559.1:p.Ala21Thr ENST00000455089.5:c.61G>A 7:g.55019338G>A EGFR ENST00000275493.6 3633 3236 K5B66H 2762307 2620566 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51767869 COSM3266583 99377861 c.1351C>T p.R451C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 29615459 NS primary 42 ENSP00000275493.2:p.Arg451Cys ENST00000275493.6:c.1351C>T 7:g.55160191C>T EGFR ENST00000275493.6 3633 3236 2644148 2644148 2504435 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM6493925 178385479 c.? p.T274M Substitution - Missense + - Variant of unknown origin 28573640 surgery - NOS NS ENSP00000275493.2:p.Thr274Met EGFR ENST00000275493.6 3633 3236 1593021 1593021 1513947 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1191243 1191243 1103139 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSM29291 178386178 c.? p.N756S Substitution - Missense + - Variant of unknown origin 19047896 surgery-fixed NS ENSP00000275493.2:p.Asn756Ser EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194739 1194739 1106634 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51818096 COSM29341 132580316 c.1725C>G p.C575W Substitution - Missense 38 7:55165417-55165417 + - PATHOGENIC .989 Variant of unknown origin 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Cys575Trp ENST00000454757.6:c.1725C>G 7:g.55165417C>G EGFR ENST00000275493.6 3633 3236 1875145 1875145 1765736 NS NS NS NS carcinoid-endocrine_tumour NS NS NS n COSM20894 178379162 c.? p.A859T Substitution - Missense + - Variant of unknown origin 23139256 fixed - NOS NS ENSP00000275493.2:p.Ala859Thr EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732915 2732915 2591668 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827181 COSM7002280 132590450 c.439C>G p.P147A Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .86378 Variant of unknown origin 28855349 surgery - NOS recurrent 58 ENSP00000395243.3:p.Pro147Ala ENST00000454757.6:c.439C>G 7:g.55151308C>G EGFR ENST00000275493.6 3633 3236 1997145 1997145 1882354 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23930206 fixed - NOS metastasis 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000063 2000063 1884961 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS 85 ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 2000063 2000063 1884961 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS 85 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1444767 1444767 1369010 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618800 1618800 1537552 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 54 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2148617 2148617 2017747 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1074916 1074916 990170 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17508947 surgery fresh/frozen primary 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51832145 COSM6493936 99406880 c.2389T>G p.C797G Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95801 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000275493.2:p.Cys797Gly ENST00000275493.6:c.2389T>G 7:g.55181398T>G EGFR ENST00000275493.6 3633 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51770694 COSM20891 99391373 c.2386G>A p.G796S Substitution - Missense 38 7:55181395-55181395 + Yes PATHOGENIC .98244 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000275493.2:p.Gly796Ser ENST00000275493.6:c.2386G>A 7:g.55181395G>A EGFR ENST00000275493.6 3633 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766880 COSM28516 99392483 c.2404G>T p.V802F Substitution - Missense 38 7:55181413-55181413 + - PATHOGENIC .89385 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000275493.2:p.Val802Phe ENST00000275493.6:c.2404G>T 7:g.55181413G>T EGFR ENST00000275493.6 3633 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 99392449 c.2374C>T p.L792F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000275493.2:p.Leu792Phe ENST00000275493.6:c.2374C>T 7:g.55181383C>T EGFR ENST00000275493.6 3633 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51832120 COSM6493935 99420070 c.2386G>C p.G796R Substitution - Missense 38 7:55181395-55181395 + Yes PATHOGENIC .98511 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000275493.2:p.Gly796Arg ENST00000275493.6:c.2386G>C 7:g.55181395G>C EGFR ENST00000275493.6 3633 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 99388191 c.2389T>A p.C797S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2389T>A 7:g.55181398T>A EGFR ENST00000275493.6 3633 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 99392455 c.2375T>A p.L792H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000275493.2:p.Leu792His ENST00000275493.6:c.2375T>A 7:g.55181384T>A EGFR ENST00000275493.6 3633 3236 1551563 1551563 1473668 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21603 178379091 c.? p.R776H Substitution - Missense + - Variant of unknown origin 21858063 surgery-fixed NS ENSP00000275493.2:p.Arg776His EGFR ENST00000275493.6 3633 3236 1047965 1047965 964193 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM23623 178382228 c.? p.H773R Substitution - Missense + - Variant of unknown origin 17337084 surgery-fixed NS ENSP00000275493.2:p.His773Arg EGFR ENST00000275493.6 3633 3236 1047970 1047970 964198 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM23623 178382228 c.? p.H773R Substitution - Missense + - Variant of unknown origin 17337084 surgery-fixed NS ENSP00000275493.2:p.His773Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 H1568 2776237 2634373 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51803615 COSM3266664 132550290 c.3244G>A p.D1082N Substitution - Missense 38 7:55205363-55205363 + - NEUTRAL .13639 Variant of unknown origin 29681454 NS NS 48 ENSP00000395243.3:p.Asp1082Asn ENST00000454757.6:c.3244G>A 7:g.55205363G>A EGFR ENST00000275493.6 3633 3236 2672933 2672933 2532449 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1716337 178378584 c.? p.A289V Substitution - Missense + - Variant of unknown origin 26191234 surgery-fixed primary ENSP00000275493.2:p.Ala289Val EGFR ENST00000275493.6 3633 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 99392475 c.2390G>C p.C797S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2390G>C 7:g.55181399G>C EGFR ENST00000275493.6 3633 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1599035 1599035 1519522 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 22091430 fixed - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2046058 2046058 1926353 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637082 1637082 1553130 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1594588 1594588 1515556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51776191 COSM133565 99387374 c.2387G>A p.G796D Substitution - Missense 38 7:55181396-55181396 + - PATHOGENIC .96481 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000275493.2:p.Gly796Asp ENST00000275493.6:c.2387G>A 7:g.55181396G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2841802 2841802 2697351 soft_tissue fibrous_tissue_and_uncertain_origin NS NS desmoid_tumour-fibromatosis NS NS NS n COSV104576752 COSM9414781 133239829 c.3056G>A p.S1019N Substitution - Missense 38 7:55202545-55202545 + - PATHOGENIC .89459 Variant of unknown origin 32099073 surgery-fixed NS ENSP00000415559.1:p.Ser1019Asn ENST00000455089.5:c.3056G>A 7:g.55202545G>A EGFR ENST00000275493.6 3633 3236 2625562 2625562 2485974 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 99380328 c.2612C>G p.A871G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 27056568 surgery-fixed NS 51 ENSP00000275493.2:p.Ala871Gly ENST00000275493.6:c.2612C>G 7:g.55191861C>G EGFR ENST00000275493.6 3633 3236 1179648 1179648 1091610 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1036627 1036627 953384 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM22419 178384163 c.? p.W731R Substitution - Missense + - Variant of unknown origin 17201173 NS NS EGFR ENST00000275493.6 3633 3236 1837422 1837422 1731621 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 23242437 NS NS 68 ENSP00000275493.2:p.Glu709Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1477704 1477704 1401403 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51848641 COSM85750 133244505 c.2168_2170delinsTCT p.S723_V724delinsIL Substitution - Missense 38 7:55181312-55181314 + - Variant of unknown origin 21052000 surgery fresh/frozen NS ENSP00000415559.1:p.Ser723_Val724delinsIleLeu ENST00000455089.5:c.2168_2170delinsTCT 7:g.55181312_55181314delinsTCT EGFR ENST00000275493.6 3633 3236 1857888 1857888 1750378 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1169668 178384701 c.? p.I91L Substitution - Missense + - Variant of unknown origin 23243055 surgery-fixed recurrent ENSP00000275493.2:p.Ile91Leu EGFR ENST00000275493.6 3633 3236 2625560 2625560 2485972 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 99380328 c.2612C>G p.A871G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 27056568 surgery-fixed NS 51 ENSP00000275493.2:p.Ala871Gly ENST00000275493.6:c.2612C>G 7:g.55191861C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2579301 2579301 2440638 NS NS NS NS malignant_melanoma NS NS NS n COSV51772282 COSM133202 133212823 c.2201G>A p.G734D Substitution - Missense 38 7:55181345-55181345 + - PATHOGENIC .98244 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000415559.1:p.Gly734Asp ENST00000455089.5:c.2201G>A 7:g.55181345G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592964 1592964 1513890 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51801589 COSM133199 133210332 c.2111A>G p.E704G Substitution - Missense 38 7:55174783-55174783 + - PATHOGENIC .9946 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000415559.1:p.Glu704Gly ENST00000455089.5:c.2111A>G 7:g.55174783A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162199 1162199 1074531 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51783638 COSM28514 132576900 c.2360G>T p.R787L Substitution - Missense 38 7:55191744-55191744 + - PATHOGENIC .96073 Variant of unknown origin 19020901 NS NS ENSP00000395243.3:p.Arg787Leu ENST00000454757.6:c.2360G>T 7:g.55191744G>T EGFR ENST00000275493.6 3633 3236 1661390 1661390 1575005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830604 COSM214351 99387216 c.2339T>C p.I780T Substitution - Missense 38 7:55181348-55181348 + - PATHOGENIC .97073 Variant of unknown origin 22483783 surgery-fixed NS 57 ENSP00000275493.2:p.Ile780Thr ENST00000275493.6:c.2339T>C 7:g.55181348T>C EGFR ENST00000275493.6 3633 3236 AA3-2 2539101 2400690 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSM133708 178380057 c.? p.V774M Substitution - Missense + - Variant of unknown origin 25257301 surgery-fixed NS ENSP00000275493.2:p.Val774Met EGFR ENST00000275493.6 3633 3236 1077369 1077369 992623 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1167794 1167794 1080036 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM28619 178383742 c.? p.V786M Substitution - Missense + - Variant of unknown origin 19057270 surgery - NOS NS ENSP00000275493.2:p.Val786Met EGFR ENST00000275493.6 3633 3236 TC71 2294589 2160616 bone NS NS NS Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour NS NS NS y COSV51765987 COSM4587485 99454498 c.3142G>T p.A1048S Substitution - Missense 38 7:55201762-55201762 + - NEUTRAL .47883 Variant of unknown origin 25186949 cell-line NS ENSP00000275493.2:p.Ala1048Ser ENST00000275493.6:c.3142G>T 7:g.55201762G>T EGFR ENST00000275493.6 3633 3236 1479099 1479099 1402792 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162181 1162181 1074513 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780223 COSM28511 133223277 c.1973T>C p.L658P Substitution - Missense 38 7:55173967-55173967 + - PATHOGENIC .90657 Variant of unknown origin 19020901 NS NS ENSP00000415559.1:p.Leu658Pro ENST00000455089.5:c.1973T>C 7:g.55173967T>C EGFR ENST00000275493.6 3633 3236 1891236 1891236 1780605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471808 1471808 1395546 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51770642 COSM22992 99380893 c.2161G>A p.G721S Substitution - Missense 38 7:55174020-55174020 + - PATHOGENIC .98289 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000275493.2:p.Gly721Ser ENST00000275493.6:c.2161G>A 7:g.55174020G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043127 1043127 959468 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51836619 COSM22950 132557234 c.2216C>A p.S739Y Substitution - Missense 38 7:55181360-55181360 + - PATHOGENIC .95471 Variant of unknown origin 17224267 surgery-fixed NS 61 ENSP00000395243.3:p.Ser739Tyr ENST00000454757.6:c.2216C>A 7:g.55181360C>A EGFR ENST00000275493.6 3633 3236 2139544 2139544 2009051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24649318 surgery-fixed primary 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2479710 2479710 2342456 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891233 1891233 1780602 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2083474 2083474 1961757 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481316 surgery - NOS primary 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2432394 2432394 2295297 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM5352244 178383832 c.? p.G810D Substitution - Missense + - Variant of unknown origin 26462025 surgery - NOS metastasis ENSP00000275493.2:p.Gly810Asp EGFR ENST00000275493.6 3633 3236 2345017 2345017 2209689 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2344988 2344988 2209660 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1734098 1734098 1640047 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 22842370 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2672947 2672947 2532452 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1716337 178378584 c.? p.A289V Substitution - Missense + - Variant of unknown origin 26191234 surgery-fixed primary ENSP00000275493.2:p.Ala289Val EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043868 1043868 960209 lung NS NS NS carcinoma spindle_cell_carcinoma NS NS n COSV51770611 COSM22993 133253710 c.2027G>A p.G676D Substitution - Missense 38 7:55174021-55174021 + - PATHOGENIC .98289 Variant of unknown origin 17192902 NS NS ENSP00000415559.1:p.Gly676Asp ENST00000455089.5:c.2027G>A 7:g.55174021G>A EGFR ENST00000275493.6 3633 3236 1279044 1279044 1190340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed primary 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345555 2345555 2210227 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637213 1637213 1553261 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2906650 2906650 2760901 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29616327 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1770616 1770616 1674856 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1994265 1994265 1879520 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23886169 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-GE057-T1 2869770 2724767 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110798 COSM9656412 133283000 c.2944_2945delinsTT p.P982F Substitution - Missense 38 7:55201320-55201321 + - Variant of unknown origin 26950094 surgery - NOS NS 89 ENSP00000415559.1:p.Pro982Phe ENST00000455089.5:c.2944_2945delinsTT 7:g.55201320_55201321delinsTT EGFR ENST00000275493.6 3633 3236 2822123 2822123 2677983 endometrium NS NS NS carcinoma adenocarcinoma NS NS n COSM1684817 178382662 c.? p.G863D Substitution - Missense + - Variant of unknown origin 26373574 fixed - NOS NS ENSP00000275493.2:p.Gly863Asp EGFR ENST00000275493.6 3633 3236 1770643 1770643 1674883 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 MG-176-tumor 2819069 2675368 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1594126 1594126 1515050 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724887 surgery fresh/frozen NS 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096205 2096205 1974269 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 1983790 1983790 1870026 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 23796143 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2345037 2345037 2209709 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1166418 1166418 1078732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51786190 COSM28606 99378277 c.2564A>G p.D855G Substitution - Missense het 38 7:55191813-55191813 + - PATHOGENIC .9858 Variant of unknown origin 16870303 surgery - NOS NS 59 ENSP00000275493.2:p.Asp855Gly ENST00000275493.6:c.2564A>G 7:g.55191813A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659761 2659761 2519919 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51802260 COSM6506511 133258214 c.1997A>G p.E666G Substitution - Missense 38 7:55173991-55173991 + - PATHOGENIC .97458 Variant of unknown origin 28744312 surgery-fixed NS ENSP00000415559.1:p.Glu666Gly ENST00000455089.5:c.1997A>G 7:g.55173991A>G EGFR ENST00000275493.6 3633 3236 1054392 1054392 970463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 1054392 1054392 970463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777782 COSM6227 99381636 c.2504A>T p.H835L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000275493.2:p.His835Leu ENST00000275493.6:c.2504A>T 7:g.55191753A>T EGFR ENST00000275493.6 3633 3236 2156998 2156998 2025973 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014314 1014314 931488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1981024 1981024 1867260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594552 1594552 1515520 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772314 COSM27568 133206969 c.2252G>C p.G751A Substitution - Missense 38 7:55181396-55181396 + - PATHOGENIC .95257 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000415559.1:p.Gly751Ala ENST00000455089.5:c.2252G>C 7:g.55181396G>C EGFR ENST00000275493.6 3633 3236 1479942 1479942 1403602 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1140937 1140937 1053385 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448998 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095945 2095945 1974009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1089117 1089117 1004071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1089117 1089117 1004071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 1631941 1631941 1548811 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096174 2096174 1974238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594604 1594604 1515572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767322 COSM133630 132591575 c.2438_2439delinsGA p.L813R Substitution - Missense 38 7:55191822-55191823 + - Variant of unknown origin 19724844 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438_2439delinsGA 7:g.55191822_55191823delinsGA EGFR ENST00000275493.6 3633 3236 2046066 2046066 1926361 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095973 2095973 1974037 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1500583 1500583 1423462 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51765742 COSM87019 133205370 c.2267A>G p.Y756C Substitution - Missense het 38 7:55181411-55181411 + - PATHOGENIC .95822 Variant of unknown origin 21436633 surgery - NOS NS 83 ENSP00000415559.1:p.Tyr756Cys ENST00000455089.5:c.2267A>G 7:g.55181411A>G EGFR ENST00000275493.6 3633 3236 2603454 2603454 2464345 central_nervous_system brain NS NS glioma oligoastrocytoma_Grade_III anaplastic NS n COSM6024077 178383192 c.? p.S645C Substitution - Missense + - Variant of unknown origin 28042970 surgery-fixed NS 65 ENSP00000275493.2:p.Ser645Cys EGFR ENST00000275493.6 3633 3236 2081910 2081910 1960332 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1333426 1333426 1243900 salivary_gland parotid NS NS carcinoma salivary_duct_carcinoma NS NS n COSV51807024 COSM41905 99389634 c.2092G>A p.A698T Substitution - Missense 38 7:55173951-55173951 + - PATHOGENIC .96084 Variant of unknown origin 20371674 surgery-fixed NS 73 ENSP00000275493.2:p.Ala698Thr ENST00000275493.6:c.2092G>A 7:g.55173951G>A EGFR ENST00000275493.6 3633 3236 1592873 1592873 1513799 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51790353 COSM13178 99450942 c.2081C>T p.P694L Substitution - Missense 38 7:55173940-55173940 + - PATHOGENIC .97388 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000275493.2:p.Pro694Leu ENST00000275493.6:c.2081C>T 7:g.55173940C>T EGFR ENST00000275493.6 3633 3236 2081910 2081910 1960332 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2009138 2009138 1891872 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469483 1469483 1393222 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895067 1895067 1783759 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1914974 1914974 1802976 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618740 1618740 1537492 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1107789 1107789 1021692 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592980 1592980 1513906 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51852524 COSM133204 132559377 c.2363T>G p.L788W Substitution - Missense 38 7:55191747-55191747 + - PATHOGENIC .98181 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu788Trp ENST00000454757.6:c.2363T>G 7:g.55191747T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675160 2675160 2534434 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51789046 COSM6849766 132574311 c.2075A>G p.K692R Substitution - Missense 38 7:55174747-55174747 + - PATHOGENIC .98813 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000395243.3:p.Lys692Arg ENST00000454757.6:c.2075A>G 7:g.55174747A>G EGFR ENST00000275493.6 3633 3236 1838699 1838699 1732800 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2271434 2271434 2138062 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25257380 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 C331 2897780 2752079 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV99296441 COSM9178873 133237252 c.2908G>A p.E970K Substitution - Missense 38 7:55201284-55201284 + - PATHOGENIC .99529 Variant of unknown origin 31477716 surgery-fixed NS 73 ENSP00000415559.1:p.Glu970Lys ENST00000455089.5:c.2908G>A 7:g.55201284G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2026262 2026262 1908351 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765742 COSM87019 132550498 c.2267A>G p.Y756C Substitution - Missense het 38 7:55181411-55181411 + - PATHOGENIC .95822 Variant of unknown origin 24040454 surgery-fixed NS ENSP00000395243.3:p.Tyr756Cys ENST00000454757.6:c.2267A>G 7:g.55181411A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162198 1162198 1074530 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51799102 COSM28513 132559266 c.2215T>C p.S739P Substitution - Missense 38 7:55181359-55181359 + - PATHOGENIC .95834 Variant of unknown origin 19020901 NS NS ENSP00000395243.3:p.Ser739Pro ENST00000454757.6:c.2215T>C 7:g.55181359T>C EGFR ENST00000275493.6 3633 3236 1469440 1469440 1393179 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2770724 2770724 2628925 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25403583 surgery-fixed NS 49 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1110457 1110457 1024335 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1067044 1067044 983024 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 BC3-1 2824190 2680014 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51801471 COSM53105 99379999 c.2492G>A p.R831H Substitution - Missense 38 7:55191741-55191741 + - PATHOGENIC .96289 Reported in another cancer sample as somatic 31867841 circulating tumour recurrent 43 ENSP00000275493.2:p.Arg831His ENST00000275493.6:c.2492G>A 7:g.55191741G>A EGFR ENST00000275493.6 3633 3236 1235142 1235142 1146928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1235142 1235142 1146928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 57 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1966314 1966314 1852807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425744 2425744 2288665 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983161 983161 898879 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2344931 2344931 2209603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25674250 NS NS 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345101 2345101 2209773 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1493367 1493367 1416357 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1110462 1110462 1024340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1625790 1625790 1543014 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1246664 1246664 1158343 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329258 1329258 1239743 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469508 1469508 1393247 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1884041 1884041 1773930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23495083 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1896950 1896950 1785637 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23542356 surgery-fixed recurrent 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1592982 1592982 1513908 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51824363 COSM133206 99389255 c.2530C>G p.L844V Substitution - Missense 38 7:55191779-55191779 + - PATHOGENIC .9686 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu844Val ENST00000275493.6:c.2530C>G 7:g.55191779C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594586 1594586 1515554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51851559 COSM133627 132551175 c.2204T>G p.I735S Substitution - Missense 38 7:55181348-55181348 + - PATHOGENIC .97448 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000395243.3:p.Ile735Ser ENST00000454757.6:c.2204T>G 7:g.55181348T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2834143 2834143 2689927 skin mucosal nasopharynx NS malignant_melanoma NS NS NS y COSV104577150 COSM9326314 132602891 c.2834C>T p.P945L Substitution - Missense 38 7:55201210-55201210 + - PATHOGENIC .98952 Variant of unknown origin 28296713 surgery - NOS primary 73 ENSP00000395243.3:p.Pro945Leu ENST00000454757.6:c.2834C>T 7:g.55201210C>T EGFR ENST00000275493.6 3633 3236 1967529 1967529 1854021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23807543 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705478 1705478 1613384 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226899 2226899 2094634 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2069205 2069205 1948780 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24346091 NS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515265 1515265 1437875 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1637069 1637069 1553117 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1746656 1746656 1651632 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 69 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2028997 2028997 1910879 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777317 1777317 1681320 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 LU-65 946067 862593 lung NS NS NS carcinoma giant_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2579678 2579678 2441015 NS NS NS NS malignant_melanoma NS NS NS n COSV51769129 COSM6005742 99399000 c.1801_1802delinsAA p.G601K Substitution - Missense 38 7:55165358-55165359 + - Variant of unknown origin 25148578 surgery-fixed NS ENSP00000275493.2:p.Gly601Lys ENST00000275493.6:c.1801_1802delinsAA 7:g.55165358_55165359delinsAA EGFR ENST00000275493.6 3633 3236 2163019 2163019 2031603 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 24810493 surgery-fixed NS ENSP00000275493.2:p.Glu709Ala EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2113068 2113068 1987329 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51801589 COSM133199 132554773 c.2111A>G p.E704G Substitution - Missense het 38 7:55174783-55174783 + - PATHOGENIC .9946 Variant of unknown origin 24595526 surgery-fixed NS ENSP00000395243.3:p.Glu704Gly ENST00000454757.6:c.2111A>G 7:g.55174783A>G EGFR ENST00000275493.6 3633 3236 1469364 1469364 1393103 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469823 1469823 1393562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1223893 1223893 1135725 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19517135 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 S29 1063226 979271 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2078489 2078489 1957208 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2425715 2425715 2288636 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-GE005-T1 2869732 2724729 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110870 COSM9656044 132607152 c.2190_2191delinsTT p.R731C Substitution - Missense 38 7:55181334-55181335 + - Variant of unknown origin 26950094 surgery - NOS NS 69 ENSP00000395243.3:p.Arg731Cys ENST00000454757.6:c.2190_2191delinsTT 7:g.55181334_55181335delinsTT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239183 2239183 2106715 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773889 COSM14069 132579420 c.2213C>T p.T738I Substitution - Missense 38 7:55181357-55181357 + - PATHOGENIC .96109 Variant of unknown origin 25130612 surgery - NOS NS 56 ENSP00000395243.3:p.Thr738Ile ENST00000454757.6:c.2213C>T 7:g.55181357C>T EGFR ENST00000275493.6 3633 3236 1656138 1656138 1570795 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM27103 178383328 c.? p.T847I Substitution - Missense + - Variant of unknown origin 21311943 NS NS ENSP00000275493.2:p.Thr847Ile EGFR ENST00000275493.6 3633 3236 2732608 2732608 2591361 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779091 COSM2155593 99388542 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Reported in another cancer sample as somatic 26757882 surgery-fixed primary 57 ENSP00000275493.2:p.Thr363Ile ENST00000275493.6:c.1088C>T 7:g.55156614C>T EGFR ENST00000275493.6 3633 3236 CCK-81_R1_Cetux 2841357 2696917 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 99390660 c.1391C>T p.S464L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000275493.2:p.Ser464Leu ENST00000275493.6:c.1391C>T 7:g.55160231C>T EGFR ENST00000275493.6 3633 3236 2205959 2205959 2074192 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444736 1444736 1368979 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228726 2228726 2096438 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24956168 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 4624 915977 833376 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766268 COSM13183 99377562 c.2225T>C p.V742A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000275493.2:p.Val742Ala ENST00000275493.6:c.2225T>C 7:g.55174762T>C EGFR ENST00000275493.6 3633 3236 1498635 1498635 1421513 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21315472 surgery - NOS primary 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777387 1777387 1681390 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043873 1043873 960214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51770642 COSM22992 133209132 c.2026G>A p.G676S Substitution - Missense 38 7:55174020-55174020 + - PATHOGENIC .98289 Variant of unknown origin 17192902 NS NS ENSP00000415559.1:p.Gly676Ser ENST00000455089.5:c.2026G>A 7:g.55174020G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778592 2778592 2636646 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV99286294 COSM7410342 132585642 c.2324A>G p.Q775R Substitution - Missense 38 7:55181468-55181468 + - PATHOGENIC .95287 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000395243.3:p.Gln775Arg ENST00000454757.6:c.2324A>G 7:g.55181468A>G EGFR ENST00000275493.6 3633 3236 1166430 1166430 1078744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773222 COSM28608 99411852 c.2393T>A p.L798H Substitution - Missense het 38 7:55181402-55181402 + - PATHOGENIC .95568 Variant of unknown origin 16870303 surgery - NOS NS 51 ENSP00000275493.2:p.Leu798His ENST00000275493.6:c.2393T>A 7:g.55181402T>A EGFR ENST00000275493.6 3633 3236 1135553 1135553 1048117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26412 178384237 c.? p.G779S Substitution - Missense + - Variant of unknown origin 18676761 NS NS 76 ENSP00000275493.2:p.Gly779Ser EGFR ENST00000275493.6 3633 3236 1141193 1141193 1053641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 18785203 autopsy-fixed NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141193 1141193 1053641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 18785203 autopsy-fixed NS 76 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1166431 1166431 1078745 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51803731 COSM28604 99377260 c.2506C>T p.R836C Substitution - Missense het 38 7:55191755-55191755 + - PATHOGENIC .95213 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 48 ENSP00000275493.2:p.Arg836Cys ENST00000275493.6:c.2506C>T 7:g.55191755C>T EGFR ENST00000275493.6 3633 3236 2616329 2616329 2476815 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26118982 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 983128 983128 898846 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875336 1875336 1765919 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2579438 2579438 2440775 NS NS NS NS malignant_melanoma NS NS NS n COSV51781415 COSM6005739 99419370 c.326G>A p.G109E Substitution - Missense 38 7:55143390-55143390 + - PATHOGENIC .99562 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000275493.2:p.Gly109Glu ENST00000275493.6:c.326G>A 7:g.55143390G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879493 1879493 1769995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1032006 1032006 948797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17060940 pleural effusion NS 65 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077332 1077332 992586 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302280 1302280 1213331 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 8 2760115 2618648 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51797913 COSM7339051 133212495 c.2370C>A p.H790Q Substitution - Missense 38 7:55191754-55191754 + - PATHOGENIC .83351 Variant of unknown origin 29876005 surgery-fixed NS ENSP00000415559.1:p.His790Gln ENST00000455089.5:c.2370C>A 7:g.55191754C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162205 1162205 1074537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51829394 COSM28515 132598432 c.2628C>A p.S876R Substitution - Missense 38 7:55198778-55198778 + - .69453 Variant of unknown origin 19020901 NS NS ENSP00000395243.3:p.Ser876Arg ENST00000454757.6:c.2628C>A 7:g.55198778C>A EGFR ENST00000275493.6 3633 3236 1667718 1667718 1581011 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM219789 178388124 c.? p.S768N Substitution - Missense + - Variant of unknown origin 22528563 NS NS ENSP00000275493.2:p.Ser768Asn EGFR ENST00000275493.6 3633 3236 2345111 2345111 2209783 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2595753 2595753 2456629 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 27538584 surgery-fixed NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1661390 1661390 1575005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830604 COSM214351 133215422 c.2204T>C p.I735T Substitution - Missense 38 7:55181348-55181348 + - PATHOGENIC .97073 Variant of unknown origin 22483783 surgery-fixed NS 57 ENSP00000415559.1:p.Ile735Thr ENST00000455089.5:c.2204T>C 7:g.55181348T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162176 1162176 1074508 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51818033 COSM28508 132568563 c.1969G>T p.A657S Substitution - Missense 38 7:55173963-55173963 + - PATHOGENIC .97325 Variant of unknown origin 19020901 NS NS ENSP00000395243.3:p.Ala657Ser ENST00000454757.6:c.1969G>T 7:g.55173963G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-08-0349-01 1910225 1798516 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51830791 COSM43068 132617248 c.842G>A p.C281Y Substitution - Missense het 38 7:55155917-55155917 + - PATHOGENIC .99356 Variant of unknown origin 329 fresh/frozen - NOS primary 46 ENSP00000395243.3:p.Cys281Tyr ENST00000454757.6:c.842G>A 7:g.55155917G>A EGFR ENST00000275493.6 3633 3236 921160 921160 838119 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16002952 surgery-fixed primary 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179113 1179113 1091075 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19185949 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638738 1638738 1554737 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1047 2491942 2354571 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour borderline NS n COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 26437033 surgery fresh/frozen NS 63 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 1120919 1120919 1034075 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM27104 178383972 c.? p.H850D Substitution - Missense + - Variant of unknown origin 18509184 NS NS ENSP00000275493.2:p.His850Asp EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166430 1166430 1078744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773237 COSM28609 133238380 c.2281A>G p.K761E Substitution - Missense het 38 7:55181425-55181425 + - PATHOGENIC .9712 Variant of unknown origin 16870303 surgery - NOS NS 51 ENSP00000415559.1:p.Lys761Glu ENST00000455089.5:c.2281A>G 7:g.55181425A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043864 1043864 960205 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 NPC0001PT00196T00196 2857366 2712666 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1043858 1043858 960199 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862709 2862709 2717872 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2011151 2011151 1893789 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1661390 1661390 1575005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51799102 COSM28513 133215426 c.2215T>C p.S739P Substitution - Missense 38 7:55181359-55181359 + - PATHOGENIC .95834 Variant of unknown origin 22483783 surgery-fixed NS 57 ENSP00000415559.1:p.Ser739Pro ENST00000455089.5:c.2215T>C 7:g.55181359T>C EGFR ENST00000275493.6 3633 3236 1469857 1469857 1393596 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469857 1469857 1393596 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083064 1083064 998229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17685931 surgery-fixed NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2432452 2432452 2295353 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25798276 NS NS 86 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402513 2402513 2265369 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1471806 1471806 1395544 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51799872 COSM53266 99426449 c.2165C>T p.A722V Substitution - Missense 38 7:55174024-55174024 + - PATHOGENIC .97625 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000275493.2:p.Ala722Val ENST00000275493.6:c.2165C>T 7:g.55174024C>T EGFR ENST00000275493.6 3633 3236 2840788 2840788 2696348 prostate NS NS NS carcinoma NS NS NS n COSV51807481 COSM1716255 99380046 c.2152C>A p.L718M Substitution - Missense 38 7:55174011-55174011 + - PATHOGENIC .91907 Variant of unknown origin 31874108 surgery-fixed metastasis ENSP00000275493.2:p.Leu718Met ENST00000275493.6:c.2152C>A 7:g.55174011C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 WSU-HN13 2296298 2161901 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51826894 COSM4601600 132589070 c.2182C>T p.H728Y Substitution - Missense 38 7:55181326-55181326 + - PATHOGENIC .94421 Variant of unknown origin 25275298 cell-line NS ENSP00000395243.3:p.His728Tyr ENST00000454757.6:c.2182C>T 7:g.55181326C>T EGFR ENST00000275493.6 3633 3236 2096199 2096199 1974263 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 2264361 2264361 2131345 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR ENST00000275493.6 3633 3236 2344974 2344974 2209646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2345000 2345000 2209672 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2062141 2062141 1942220 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51850053 COSM1717823 133229080 c.2450T>G p.L817R Substitution - Missense het 38 7:55191834-55191834 + - PATHOGENIC .98155 Variant of unknown origin 24279718 surgery-fixed recurrent 61 ENSP00000415559.1:p.Leu817Arg ENST00000455089.5:c.2450T>G 7:g.55191834T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 HCC461 2776316 2634452 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99034466 COSM7365976 132591349 c.3386A>G p.Q1129R Substitution - Missense 38 7:55205505-55205505 + - PATHOGENIC .94623 Variant of unknown origin 29681454 NS NS 69 ENSP00000395243.3:p.Gln1129Arg ENST00000454757.6:c.3386A>G 7:g.55205505A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778589 2778589 2636643 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV99296854 COSM7410338 132609333 c.2264A>G p.D755G Substitution - Missense 38 7:55181408-55181408 + - PATHOGENIC .9793 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000395243.3:p.Asp755Gly ENST00000454757.6:c.2264A>G 7:g.55181408A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD_E01166 1765174 1669494 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51795467 COSM390866 132565463 c.574_575delinsTA p.A192Y Substitution - Missense 38 7:55152626-55152627 + - Variant of unknown origin 22980975 surgery - NOS primary ENSP00000395243.3:p.Ala192Tyr ENST00000454757.6:c.574_575delinsTA 7:g.55152626_55152627delinsTA EGFR ENST00000275493.6 3633 3236 1777327 1777327 1681330 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246703 1246703 1158382 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046010 2046010 1926305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862399 2862399 2717585 lung right_lower_lobe NS NS carcinoma adenocarcinoma transformed_to_sarcomatoid_carcinoma NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 31561203 surgery - NOS metastasis 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1141303 1141303 1053751 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246714 1246714 1158393 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2834143 2834143 2689927 skin mucosal nasopharynx NS malignant_melanoma NS NS NS y COSV104577149 COSM9326313 132602885 c.2117C>A p.T706K Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99307 Variant of unknown origin 28296713 surgery - NOS primary 73 ENSP00000395243.3:p.Thr706Lys ENST00000454757.6:c.2117C>A 7:g.55174789C>A EGFR ENST00000275493.6 3633 3236 1026389 1026389 943365 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17047648 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422791 2422791 2285713 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345595 2345595 2210267 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345352 2345352 2210024 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027726 2027726 1909629 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1444747 1444747 1368990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2625580 2625580 2485992 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 74 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471809 1471809 1395547 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51780223 COSM28511 132566687 c.1973T>C p.L658P Substitution - Missense 38 7:55173967-55173967 + - PATHOGENIC .90657 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000395243.3:p.Leu658Pro ENST00000454757.6:c.1973T>C 7:g.55173967T>C EGFR ENST00000275493.6 3633 3236 1468088 1468088 1391934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618822 1618822 1537574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 57 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594588 1594588 1515556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51776191 COSM133565 133215541 c.2252G>A p.G751D Substitution - Missense 38 7:55181396-55181396 + - PATHOGENIC .96481 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000415559.1:p.Gly751Asp ENST00000455089.5:c.2252G>A 7:g.55181396G>A EGFR ENST00000275493.6 3633 3236 1695224 1695224 1603444 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51799102 COSM28513 99387223 c.2350T>C p.S784P Substitution - Missense 38 7:55181359-55181359 + - PATHOGENIC .95834 Variant of unknown origin 22607702 surgery-fixed NS ENSP00000275493.2:p.Ser784Pro ENST00000275493.6:c.2350T>C 7:g.55181359T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-GE049-T1 2869762 2724759 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110412 COSM9799019 132621798 c.448C>T p.P150S Substitution - Missense 38 7:55151317-55151317 + - NEUTRAL .41768 Variant of unknown origin 26950094 surgery - NOS NS 80 ENSP00000395243.3:p.Pro150Ser ENST00000454757.6:c.448C>T 7:g.55151317C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-GE049-T1 2869762 2724759 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110413 COSM9799052 132621811 c.2860C>T p.R954C Substitution - Missense 38 7:55201236-55201236 + - PATHOGENIC .99346 Variant of unknown origin 26950094 surgery - NOS NS 80 ENSP00000395243.3:p.Arg954Cys ENST00000454757.6:c.2860C>T 7:g.55201236C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1456580 1456580 1380555 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1884154 1884154 1774041 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1246721 1246721 1158400 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593031 1593031 1513957 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51776171 COSM28605 133254151 c.2476G>A p.A826T Substitution - Missense 38 7:55191860-55191860 + - PATHOGENIC .9853 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000415559.1:p.Ala826Thr ENST00000455089.5:c.2476G>A 7:g.55191860G>A EGFR ENST00000275493.6 3633 3236 1141304 1141304 1053752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1000054 1000054 917277 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1996582 1996582 1881791 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23922984 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551554 1551554 1473659 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246660 1246660 1158339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2239185 2239185 2106717 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 25130612 fine needle aspirate NS 68 ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 2239185 2239185 2106717 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 fine needle aspirate NS 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1937518 1937518 1824452 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2027351 2027351 1909419 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 40 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875378 1875378 1765961 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924349 924349 841124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51801258 COSM13553 133216298 c.2437_2438inv p.L813R Substitution - Missense 38 7:55191821-55191822 + - Variant of unknown origin 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2437_2438inv 7:g.55191821_55191822inv EGFR ENST00000275493.6 3633 3236 1770508 1770508 1674748 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LPS3 2800446 2657262 soft_tissue fat NS NS liposarcoma well_differentiated NS NS n COSV99289299 COSM9110946 133243650 c.1114C>T p.L372F Substitution - Missense 38 7:55157704-55157704 + - PATHOGENIC .98762 Variant of unknown origin 26643872 surgery - NOS primary ENSP00000415559.1:p.Leu372Phe ENST00000455089.5:c.1114C>T 7:g.55157704C>T EGFR ENST00000275493.6 3633 3236 2425750 2425750 2288671 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228273 2228273 2096004 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1516782 1516782 1439376 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21575212 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118420 2118420 1992655 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 PEN-157 2843148 2698601 skin NS NS NS benign_melanocytic_nevus NS NS NS n COSV104576988 COSM9515585 99396304 c.2716G>A p.E906K Substitution - Missense 38 7:55198731-55198731 + - PATHOGENIC .99414 Variant of unknown origin 27890785 surgery-fixed NS ENSP00000275493.2:p.Glu906Lys ENST00000275493.6:c.2716G>A 7:g.55198731G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2689645 2689645 2548622 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm peripheral_T_cell_lymphoma_unspecified NS NS n COSV99294651 COSM9178023 132581852 c.1877G>A p.R626H Substitution - Missense 38 7:55173075-55173075 + - PATHOGENIC .98385 Variant of unknown origin 27203213 surgery-fixed NS 75 ENSP00000395243.3:p.Arg626His ENST00000454757.6:c.1877G>A 7:g.55173075G>A EGFR ENST00000275493.6 3633 3236 1481227 1481227 1404856 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264289 2264289 2131273 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444750 1444750 1368993 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425733 2425733 2288654 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237686 1237686 1149433 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2667826 2667826 2527488 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1169669 178386037 c.? p.T263P Substitution - Missense + - Reported in another cancer sample as somatic 28663030 surgery-fixed primary ENSP00000275493.2:p.Thr263Pro EGFR ENST00000275493.6 3633 3236 2046023 2046023 1926318 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1481230 1481230 1404859 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525677 2525677 2387866 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2225972 2225972 2093707 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891183 1891183 1780552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1026378 1026378 943354 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17047648 surgery-fixed primary 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1672437 1672437 1585491 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 21729655 surgery-fixed metastasis 72 ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 1672437 1672437 1585491 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 21729655 surgery-fixed metastasis 72 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1591043 1591043 1512159 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009143 2009143 1891877 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895108 1895108 1783800 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1638757 1638757 1554756 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2009154 2009154 1891888 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2474560 2474560 2337329 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25882025 surgery - NOS NS 63 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1471811 1471811 1395549 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51795335 COSM53232 99416647 c.2122A>G p.K708E Substitution - Missense 38 7:55173981-55173981 + - PATHOGENIC .98155 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000275493.2:p.Lys708Glu ENST00000275493.6:c.2122A>G 7:g.55173981A>G EGFR ENST00000275493.6 3633 3236 TCGA-55-6968-01 1913999 1802281 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51765668 COSM13198 99380968 c.2596G>A p.E866K Substitution - Missense 38 7:55191845-55191845 + - PATHOGENIC .98912 Variant of unknown origin 417 fresh/frozen - NOS primary 61 ENSP00000275493.2:p.Glu866Lys ENST00000275493.6:c.2596G>A 7:g.55191845G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659763 2659763 2519921 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51862250 COSM6506515 132598700 c.2007G>T p.K669N Substitution - Missense 38 7:55174001-55174001 + - PATHOGENIC .88062 Variant of unknown origin 28744312 surgery-fixed NS ENSP00000395243.3:p.Lys669Asn ENST00000454757.6:c.2007G>T 7:g.55174001G>T EGFR ENST00000275493.6 3633 3236 1235136 1235136 1146922 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 65 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879233 1879233 1769788 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51833668 COSM12675 132590886 c.2440G>A p.A814T Substitution - Missense 38 7:55191824-55191824 + - PATHOGENIC .98898 Variant of unknown origin 23468066 surgery-fixed NS 66 ENSP00000395243.3:p.Ala814Thr ENST00000454757.6:c.2440G>A 7:g.55191824G>A EGFR ENST00000275493.6 3633 3236 1202558 1202558 1114444 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2260327 2260327 2127312 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25263855 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2651878 2651878 2512016 NS NS NS NS malignant_melanoma NS NS NS n COSV51778029 COSM6268 133209348 c.2122C>T p.P708S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 24336498 xenograft NS ENSP00000415559.1:p.Pro708Ser ENST00000455089.5:c.2122C>T 7:g.55174794C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PC-9-GR-step 1896428 1785118 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23542356 cell-line NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879541 1879541 1770043 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2857410 2857410 2712710 skin NS NS NS malignant_melanoma NS NS NS n COSV51767869 COSM3266583 132551074 c.1216C>T p.R406C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 31980996 surgery-fixed NS ENSP00000395243.3:p.Arg406Cys ENST00000454757.6:c.1216C>T 7:g.55160191C>T EGFR ENST00000275493.6 3633 3236 1777239 1777239 1681242 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1627734 1627734 1544646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM86999 178381421 c.? p.S784F Substitution - Missense + - Variant of unknown origin 22302407 fixed - NOS NS ENSP00000275493.2:p.Ser784Phe EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1500177 1500177 1423056 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453497 1453497 1377530 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2905794 2905794 2760046 meninges NS NS NS meningioma NS NS NS n COSM10002148 178381609 c.? p.G810S Substitution - Missense + - Variant of unknown origin 31872418 surgery - NOS NS ENSP00000275493.2:p.Gly810Ser EGFR ENST00000275493.6 3633 3236 1083326 1083326 998491 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM23615 178387435 c.? p.K713F Substitution - Missense + - Variant of unknown origin 17596643 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1838676 1838676 1732777 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625562 2625562 2485974 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 133208531 c.2477C>G p.A826G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 27056568 surgery-fixed NS 51 ENSP00000415559.1:p.Ala826Gly ENST00000455089.5:c.2477C>G 7:g.55191861C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166430 1166430 1078744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773249 COSM28610 133238386 c.2306T>C p.L769P Substitution - Missense het 38 7:55181450-55181450 + - PATHOGENIC .94523 Variant of unknown origin 16870303 surgery - NOS NS 51 ENSP00000415559.1:p.Leu769Pro ENST00000455089.5:c.2306T>C 7:g.55181450T>C EGFR ENST00000275493.6 3633 3236 2432397 2432397 2295300 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM5352245 178388220 c.? p.C775Y Substitution - Missense + - Variant of unknown origin 26462025 surgery - NOS metastasis ENSP00000275493.2:p.Cys775Tyr EGFR ENST00000275493.6 3633 3236 1996573 1996573 1881782 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1666916 178385282 c.? p.A840T Substitution - Missense + - Variant of unknown origin 23922984 surgery-fixed NS ENSP00000275493.2:p.Ala840Thr EGFR ENST00000275493.6 3633 3236 1453422 1453422 1377455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2425748 2425748 2288669 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2865566 2865566 2720696 lung NS NS NS carcinoma adenocarcinoma transformed_to_small_cell_carcinoma NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29120087 surgery-fixed recurrent 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105826 2105826 1983864 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1638768 1638768 1554767 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777312 1777312 1681315 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141286 1141286 1053734 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095953 2095953 1974017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047773 2047773 1928045 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770544 1770544 1674784 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1593024 1593024 1513950 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1637195 1637195 1553243 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 MBC528 2807307 2664011 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99296827 COSM9120819 99456436 c.2294T>A p.V765E Substitution - Missense 38 7:55181303-55181303 + - PATHOGENIC .97894 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000275493.2:p.Val765Glu ENST00000275493.6:c.2294T>A 7:g.55181303T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625560 2625560 2485972 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 133208531 c.2477C>G p.A826G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 27056568 surgery-fixed NS 51 ENSP00000415559.1:p.Ala826Gly ENST00000455089.5:c.2477C>G 7:g.55191861C>G EGFR ENST00000275493.6 3633 3236 2345038 2345038 2209710 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1986228 1986228 1872464 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21602 178380317 c.? p.L833V Substitution - Missense + - Variant of unknown origin 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu833Val EGFR ENST00000275493.6 3633 3236 1795770 1795770 1697518 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23110940 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777389 1777389 1681392 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148611 2148611 2017741 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1860419 1860419 1751360 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1235620 1235620 1147383 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19584155 surgery-fixed primary 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 B00527 2767140 2625359 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV99034451 COSM7346340 99374200 c.3596G>T p.R1199M Substitution - Missense 38 7:55205580-55205580 + - PATHOGENIC .94501 Variant of unknown origin 30200630 surgery-fixed NS ENSP00000275493.2:p.Arg1199Met ENST00000275493.6:c.3596G>T 7:g.55205580G>T EGFR ENST00000275493.6 3633 3236 2095893 2095893 1973957 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1231311 1231311 1143101 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2422920 2422920 2285842 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1471808 1471808 1395546 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51853427 COSM53230 99444752 c.2597A>G p.E866G Substitution - Missense 38 7:55191846-55191846 + - PATHOGENIC .986 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000275493.2:p.Glu866Gly ENST00000275493.6:c.2597A>G 7:g.55191846A>G EGFR ENST00000275493.6 3633 3236 897822 897822 815444 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2595766 2595766 2456642 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1246692 1246692 1158371 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2432372 2432372 2295275 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 26473643 surgery fresh/frozen metastasis 56 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2105793 2105793 1983831 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891288 1891288 1780657 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 K5B66H 2762307 2620566 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51767869 COSM3266583 133205938 c.1216C>T p.R406C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 29615459 NS primary 42 ENSP00000415559.1:p.Arg406Cys ENST00000455089.5:c.1216C>T 7:g.55160191C>T EGFR ENST00000275493.6 3633 3236 1551562 1551562 1473667 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM100080 178390870 c.? p.K757N Substitution - Missense + - Variant of unknown origin 21858063 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2203081 2203081 2071339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 924340 924340 841115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469870 1469870 1393609 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1823856 1823856 1722250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23212424 surgery-fixed metastasis 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346552 2346552 2211215 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM133107 178380316 c.? p.H835L Substitution - Missense + - Variant of unknown origin 25687872 surgery-fixed NS ENSP00000275493.2:p.His835Leu EGFR ENST00000275493.6 3633 3236 EGCT0002 2490752 2353401 testis NS NS NS germ_cell_tumour seminoma NS NS n COSV51794554 COSM5749111 99385300 c.2690T>C p.V897A Substitution - Missense 38 7:55192830-55192830 + - PATHOGENIC .94427 Variant of unknown origin 26956871 surgery fresh/frozen primary ENSP00000275493.2:p.Val897Ala ENST00000275493.6:c.2690T>C 7:g.55192830T>C EGFR ENST00000275493.6 3633 3236 921167 921167 838126 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16002952 surgery-fixed primary 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838652 1838652 1732753 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1534787 1534787 1457124 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSM97018 178391755 c.? p.G322C Substitution - Missense + - Variant of unknown origin 21717456 NS NS EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166435 1166435 1078749 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51813062 COSM12764 132548042 c.2434G>A p.G812R Substitution - Missense het 38 7:55191818-55191818 + - PATHOGENIC .98898 Variant of unknown origin 16870303 surgery - NOS NS 70 ENSP00000395243.3:p.Gly812Arg ENST00000454757.6:c.2434G>A 7:g.55191818G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-F00368 1765250 1669570 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51799133 COSM341496 132601079 c.3165G>T p.R1055S Substitution - Missense 38 7:55205284-55205284 + - PATHOGENIC .767 Variant of unknown origin 22980975 surgery - NOS primary 82 ENSP00000395243.3:p.Arg1055Ser ENST00000454757.6:c.3165G>T 7:g.55205284G>T EGFR ENST00000275493.6 3633 3236 2644151 2644151 2504438 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM5033534 178387739 c.? p.R675Q Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS 67 ENSP00000275493.2:p.Arg675Gln EGFR ENST00000275493.6 3633 3236 2264119 2264119 2131103 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430055 1430055 1339473 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522888 1522888 1445260 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1054391 1054391 970462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264337 2264337 2131321 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095924 2095924 1973988 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046043 2046043 1926338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1166430 1166430 1078744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773249 COSM28610 99411864 c.2441T>C p.L814P Substitution - Missense het 38 7:55181450-55181450 + - PATHOGENIC .94523 Variant of unknown origin 16870303 surgery - NOS NS 51 ENSP00000275493.2:p.Leu814Pro ENST00000275493.6:c.2441T>C 7:g.55181450T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1451628 1451628 1375771 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51842583 COSM51496 132566405 c.2023T>A p.S675T Substitution - Missense 38 7:55174017-55174017 + - PATHOGENIC .97745 Variant of unknown origin 20855820 surgery - NOS NS ENSP00000395243.3:p.Ser675Thr ENST00000454757.6:c.2023T>A 7:g.55174017T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1469948 1469948 1393687 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51844854 COSM53195 132553078 c.2108G>T p.R703I Substitution - Missense 38 7:55174780-55174780 + - PATHOGENIC .99554 Variant of unknown origin 20873989 surgery fresh/frozen primary ENSP00000395243.3:p.Arg703Ile ENST00000454757.6:c.2108G>T 7:g.55174780G>T EGFR ENST00000275493.6 3633 3236 1475464 1475464 1399163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM27104 178383972 c.? p.H850D Substitution - Missense + - Variant of unknown origin 21111508 NS NS ENSP00000275493.2:p.His850Asp EGFR ENST00000275493.6 3633 3236 RERF-LC-OK 946065 862591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983747 1983747 1869983 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2011162 2011162 1893800 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921905 1921905 1809223 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891277 1891277 1780646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875360 1875360 1765943 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895090 1895090 1783782 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1623720 1623720 1541307 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21615826 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1333426 1333426 1243900 salivary_gland parotid NS NS carcinoma salivary_duct_carcinoma NS NS n COSV51807024 COSM41905 133217449 c.1957G>A p.A653T Substitution - Missense 38 7:55173951-55173951 + - PATHOGENIC .96084 Variant of unknown origin 20371674 surgery-fixed NS 73 ENSP00000415559.1:p.Ala653Thr ENST00000455089.5:c.1957G>A 7:g.55173951G>A EGFR ENST00000275493.6 3633 3236 1875144 1875144 1765735 parathyroid NS NS NS carcinoma NS NS NS n COSM1235285 178388032 c.? p.G796S Substitution - Missense + - Variant of unknown origin 23139256 fixed - NOS NS ENSP00000275493.2:p.Gly796Ser EGFR ENST00000275493.6 3633 3236 2344975 2344975 2209647 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1330081 1330081 1240566 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51809790 COSM41665 132552988 c.2366T>C p.V789A Substitution - Missense 38 7:55191750-55191750 + - PATHOGENIC .97813 Variant of unknown origin 20208477 NS metastasis ENSP00000395243.3:p.Val789Ala ENST00000454757.6:c.2366T>C 7:g.55191750T>C EGFR ENST00000275493.6 3633 3236 1235146 1235146 1146932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 85 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1067073 1067073 983053 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778591 2778591 2636645 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV99294712 COSM7410341 132563443 c.2320G>A p.V774M Substitution - Missense 38 7:55181464-55181464 + - PATHOGENIC .96467 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000395243.3:p.Val774Met ENST00000454757.6:c.2320G>A 7:g.55181464G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-NYU408 1765248 1669568 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51855104 COSM374570 132558191 c.1586G>T p.R529L Substitution - Missense 38 7:55163822-55163822 + - PATHOGENIC .93703 Variant of unknown origin 22980975 surgery - NOS primary 71 ENSP00000395243.3:p.Arg529Leu ENST00000454757.6:c.1586G>T 7:g.55163822G>T EGFR ENST00000275493.6 3633 3236 2585415 2585415 2446579 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSM6009003 178384840 c.? p.S492R Substitution - Missense + - Variant of unknown origin 25623215 surgery - NOS recurrent ENSP00000275493.2:p.Ser492Arg EGFR ENST00000275493.6 3633 3236 2822143 2822143 2678003 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSM27102 178381922 c.? p.R831H Substitution - Missense + - Variant of unknown origin 26373574 fixed - NOS NS ENSP00000275493.2:p.Arg831His EGFR ENST00000275493.6 3633 3236 1231312 1231312 1143102 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471798 1471798 1395536 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51798278 COSM53224 133256566 c.2038A>G p.T680A Substitution - Missense 38 7:55174032-55174032 + - PATHOGENIC .98345 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000415559.1:p.Thr680Ala ENST00000455089.5:c.2038A>G 7:g.55174032A>G EGFR ENST00000275493.6 3633 3236 19 2570191 2431488 skin face NS NS adnexal_tumour other sebaceoma NS n COSV51828226 COSM5991529 99405781 c.2278C>T p.L760F Substitution - Missense 38 7:55174815-55174815 + - PATHOGENIC .89342 Variant of unknown origin 27311873 surgery-fixed NS 71 ENSP00000275493.2:p.Leu760Phe ENST00000275493.6:c.2278C>T 7:g.55174815C>T EGFR ENST00000275493.6 3633 3236 1333428 1333428 1243902 salivary_gland parotid NS NS carcinoma salivary_duct_carcinoma NS NS n COSV51785879 COSM29274 99410913 c.2254T>C p.S752P Substitution - Missense 38 7:55174791-55174791 + - PATHOGENIC .99066 Variant of unknown origin 20371674 surgery-fixed NS 58 ENSP00000275493.2:p.Ser752Pro ENST00000275493.6:c.2254T>C 7:g.55174791T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592978 1592978 1513904 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51772282 COSM133202 133212823 c.2201G>A p.G734D Substitution - Missense 38 7:55181345-55181345 + - PATHOGENIC .98244 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000415559.1:p.Gly734Asp ENST00000455089.5:c.2201G>A 7:g.55181345G>A EGFR ENST00000275493.6 3633 3236 2675161 2675161 2534435 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766300 COSM6849765 99377570 c.2237A>G p.E746G Substitution - Missense 38 7:55174774-55174774 + - PATHOGENIC .97324 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000275493.2:p.Glu746Gly ENST00000275493.6:c.2237A>G 7:g.55174774A>G EGFR ENST00000275493.6 3633 3236 1102397 1102397 1016649 lung right_upper_lobe NS NS other hyperplasia NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18208799 surgery-fixed NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469417 1469417 1393156 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027858 2027858 1909761 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2148628 2148628 2017758 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2675371 2675371 2534645 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51776282 COSM1168015 99373518 c.2258C>T p.P753L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Reported in another cancer sample as somatic 29100434 surgery - NOS recurrent ENSP00000275493.2:p.Pro753Leu ENST00000275493.6:c.2258C>T 7:g.55174795C>T EGFR ENST00000275493.6 3633 3236 2027784 2027784 1909687 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027784 2027784 1909687 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264417 2264417 2131401 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1891180 1891180 1780549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1965909 1965909 1852402 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1523391 1523391 1445763 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21626329 surgery-fixed recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096063 2096063 1974127 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345850 2345850 2210522 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891304 1891304 1780673 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1921881 1921881 1809199 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444803 1444803 1369046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096072 2096072 1974136 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1860427 1860427 1751368 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1481256 1481256 1404885 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2637622 2637622 2497995 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 37 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1336421 1336421 1246806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20430469 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 19 2570191 2431488 skin face NS NS adnexal_tumour other sebaceoma NS n COSV51828195 COSM13180 133231842 c.2053C>T p.L685F Substitution - Missense 38 7:55174725-55174725 + - PATHOGENIC .96849 Variant of unknown origin 27311873 surgery-fixed NS 71 ENSP00000415559.1:p.Leu685Phe ENST00000455089.5:c.2053C>T 7:g.55174725C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 3696 915973 833372 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51828195 COSM13180 133231842 c.2053C>T p.L685F Substitution - Missense 38 7:55174725-55174725 + - PATHOGENIC .96849 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000415559.1:p.Leu685Phe ENST00000455089.5:c.2053C>T 7:g.55174725C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1333425 1333425 1243899 salivary_gland parotid NS NS carcinoma salivary_duct_carcinoma NS NS n COSV51840955 COSM41904 132579004 c.2018T>C p.L673P Substitution - Missense 38 7:55174012-55174012 + - PATHOGENIC .95988 Variant of unknown origin 20371674 surgery-fixed NS 57 ENSP00000395243.3:p.Leu673Pro ENST00000454757.6:c.2018T>C 7:g.55174012T>C EGFR ENST00000275493.6 3633 3236 2203090 2203090 2071348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2906647 2906647 2760898 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29616327 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1842958 1842958 1736206 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2031 2605270 2466161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25376516 surgery - NOS NS 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1992085 1992085 1877402 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 50 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-78-7158-01 1914062 1802344 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51768921 COSM6178049 99450834 c.2719T>A p.L907M Substitution - Missense 38 7:55198734-55198734 + - NEUTRAL .38059 Variant of unknown origin 417 fresh/frozen - NOS primary 59 ENSP00000275493.2:p.Leu907Met ENST00000275493.6:c.2719T>A 7:g.55198734T>A EGFR ENST00000275493.6 3633 3236 2861866 2861866 2717077 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM9571903 178388133 c.? p.K80T Substitution - Missense + - Variant of unknown origin 31548343 circulating tumour NS EGFR ENST00000275493.6 3633 3236 2552058 2552058 2413499 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51788909 COSM5967252 99383614 c.2588G>T p.G863V Substitution - Missense 38 7:55191837-55191837 + - PATHOGENIC .95501 Variant of unknown origin 26517354 surgery-fixed NS ENSP00000275493.2:p.Gly863Val ENST00000275493.6:c.2588G>T 7:g.55191837G>T EGFR ENST00000275493.6 3633 3236 1994272 1994272 1879527 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23886169 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2345083 2345083 2209755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1141296 1141296 1053744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179104 1179104 1091066 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19185949 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777415 1777415 1681418 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 EBC-1 946069 862595 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 EBC-1 946069 862595 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2675161 2675161 2534435 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51794723 COSM6849767 99385353 c.2212G>T p.V738F Substitution - Missense 38 7:55174749-55174749 + - PATHOGENIC .99674 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000275493.2:p.Val738Phe ENST00000275493.6:c.2212G>T 7:g.55174749G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593021 1593021 1513947 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-55-6968-01 1913999 1802281 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51765668 COSM13198 133209210 c.2461G>A p.E821K Substitution - Missense 38 7:55191845-55191845 + - PATHOGENIC .98912 Variant of unknown origin 417 fresh/frozen - NOS primary 61 ENSP00000415559.1:p.Glu821Lys ENST00000455089.5:c.2461G>A 7:g.55191845G>A EGFR ENST00000275493.6 3633 3236 1857883 1857883 1750373 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1169666 178380438 c.? p.P596L Substitution - Missense + - Variant of unknown origin 23243055 surgery-fixed recurrent ENSP00000275493.2:p.Pro596Leu EGFR ENST00000275493.6 3633 3236 1855997 1855997 1748550 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM27111 178379606 c.? p.A871G Substitution - Missense + - Variant of unknown origin 23337026 fixed - NOS primary ENSP00000275493.2:p.Ala871Gly EGFR ENST00000275493.6 3633 3236 2651874 2651874 2512014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 99385331 c.2153T>A p.L718Q Substitution - Missense hom 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Reported in another cancer sample as somatic 27257132 surgery - NOS recurrent 71 ENSP00000275493.2:p.Leu718Gln ENST00000275493.6:c.2153T>A 7:g.55174012T>A EGFR ENST00000275493.6 3633 3236 2651874 2651874 2512014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27257132 surgery - NOS recurrent 71 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2651874 2651874 2512014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 27257132 surgery - NOS recurrent 71 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1451761 1451761 1375810 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20615575 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345443 2345443 2210115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2688469 2688469 2547451 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm Langerhans_cell_histiocytosis NS NS n COSM1651575 178390362 c.? p.A743V Substitution - Missense + - Variant of unknown origin 26110571 surgery-fixed NS ENSP00000275493.2:p.Ala743Val EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KYSE-510 2267703 2134471 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51828940 COSM3266631 132553646 c.1970C>A p.A657D Substitution - Missense 38 7:55173964-55173964 + - PATHOGENIC .97734 Variant of unknown origin 25151357 cell-line NS ENSP00000395243.3:p.Ala657Asp ENST00000454757.6:c.1970C>A 7:g.55173964C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBNEC_1 2907832 2762015 biliary_tract gallbladder NS NS carcinoma small_cell_carcinoma NS NS y COSV105864119 COSM9964764 132577533 c.3004G>A p.V1002M Substitution - Missense 38 7:55201759-55201759 + - NEUTRAL .28639 Variant of unknown origin 33563892 surgery-fixed NS 66 ENSP00000395243.3:p.Val1002Met ENST00000454757.6:c.3004G>A 7:g.55201759G>A EGFR ENST00000275493.6 3633 3236 1196945 1196945 1108840 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011181 2011181 1893819 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1684818 178384529 c.? p.N826D Substitution - Missense + - Variant of unknown origin 24002608 surgery - NOS NS EGFR ENST00000275493.6 3633 3236 1592991 1592991 1513917 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1894923 1894923 1783615 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 AC-V16-Tumor-SM-9J46H 2584492 2445656 large_intestine anus NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51811313 COSM6008958 132550587 c.610C>G p.L204V Substitution - Missense 38 7:55152662-55152662 + - PATHOGENIC .95619 Variant of unknown origin 27852700 surgery-fixed recurrent ENSP00000395243.3:p.Leu204Val ENST00000454757.6:c.610C>G 7:g.55152662C>G EGFR ENST00000275493.6 3633 3236 2027742 2027742 1909645 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2732913 2732913 2591666 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 99377226 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 60 ENSP00000275493.2:p.Ala289Asp ENST00000275493.6:c.866C>A 7:g.55154129C>A EGFR ENST00000275493.6 3633 3236 1517888 1517888 1440266 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21572125 fine needle aspirate NS 47 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203105 2203105 2071363 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239186 2239186 2106718 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51787416 COSM219794 132554877 c.2364G>T p.L788F Substitution - Missense 38 7:55191748-55191748 + - PATHOGENIC .95793 Variant of unknown origin 25130612 surgery - NOS NS 76 ENSP00000395243.3:p.Leu788Phe ENST00000454757.6:c.2364G>T 7:g.55191748G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD42092a 2894833 2749321 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV105110933 COSM9881280 132588009 c.1439C>T p.S480F Substitution - Missense 38 7:55161574-55161574 + - PATHOGENIC .96213 Variant of unknown origin 33024263 surgery-fixed metastasis 75 ENSP00000395243.3:p.Ser480Phe ENST00000454757.6:c.1439C>T 7:g.55161574C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2896986 2896986 2751324 uterine_adnexa NS NS NS female_adnexal_tumour_of_probable_wolffian_origin NS NS NS n COSV105110843 COSM9876432 132547899 c.3494C>T p.A1165V Substitution - Missense 38 7:55205613-55205613 + - PATHOGENIC .9319 Variant of unknown origin 31591497 NS NS 41 ENSP00000395243.3:p.Ala1165Val ENST00000454757.6:c.3494C>T 7:g.55205613C>T EGFR ENST00000275493.6 3633 3236 2432443 2432443 2295344 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25798276 NS NS 82 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587266 1587266 1508437 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290958 2290958 2157023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095920 2095920 1973984 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525683 2525683 2387872 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM30755 178381649 c.? p.K860I Substitution - Missense + - Variant of unknown origin 27304188 ascites recurrent ENSP00000275493.2:p.Lys860Ile EGFR ENST00000275493.6 3633 3236 2732934 2732934 2591687 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51771844 COSM7002278 99386041 c.2941A>C p.I981L Substitution - Missense 38 7:55200408-55200408 + - PATHOGENIC .99358 Variant of unknown origin 28855349 surgery - NOS primary 72 ENSP00000275493.2:p.Ile981Leu ENST00000275493.6:c.2941A>C 7:g.55200408A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 133216269 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2254T>A 7:g.55181398T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 133219834 c.2239C>T p.L747F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000415559.1:p.Leu747Phe ENST00000455089.5:c.2239C>T 7:g.55181383C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 133219858 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2255G>C 7:g.55181399G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51832145 COSM6493936 133233446 c.2254T>G p.C752G Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95801 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000415559.1:p.Cys752Gly ENST00000455089.5:c.2254T>G 7:g.55181398T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766880 COSM28516 133219865 c.2269G>T p.V757F Substitution - Missense 38 7:55181413-55181413 + - PATHOGENIC .89385 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000415559.1:p.Val757Phe ENST00000455089.5:c.2269G>T 7:g.55181413G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51770694 COSM20891 133218993 c.2251G>A p.G751S Substitution - Missense 38 7:55181395-55181395 + Yes PATHOGENIC .98244 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000415559.1:p.Gly751Ser ENST00000455089.5:c.2251G>A 7:g.55181395G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51832120 COSM6493935 133245088 c.2251G>C p.G751R Substitution - Missense 38 7:55181395-55181395 + Yes PATHOGENIC .98511 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000415559.1:p.Gly751Arg ENST00000455089.5:c.2251G>C 7:g.55181395G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 133219841 c.2240T>A p.L747H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000415559.1:p.Leu747His ENST00000455089.5:c.2240T>A 7:g.55181384T>A EGFR ENST00000275493.6 3633 3236 1469446 1469446 1393185 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2131912 2131912 2005975 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24376723 fine needle aspirate primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214547 2214547 2082671 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2437327 2437327 2300177 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23211219 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542359 1542359 1464662 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 MG-264-tumor 2819115 2675414 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-J18549 2905628 2759884 NS NS NS NS malignant_melanoma NS NS NS n COSV105864529 COSM9997996 133270308 c.2789C>T p.P930L Substitution - Missense 38 7:55200391-55200391 + - PATHOGENIC .98929 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Pro930Leu ENST00000455089.5:c.2789C>T 7:g.55200391C>T EGFR ENST00000275493.6 3633 3236 1591035 1591035 1512151 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 999916 999916 917139 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16785471 surgery - NOS recurrent 49 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887406 1887406 1777078 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1334740 1334740 1245125 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20401612 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937541 1937541 1824475 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2898914 2898914 2753185 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS n COSV105863716 COSM9973512 132548812 c.2233A>T p.T745S Substitution - Missense het 38 7:55181377-55181377 + - PATHOGENIC .97936 Variant of unknown origin 27460089 blood-bone marrow NS ENSP00000395243.3:p.Thr745Ser ENST00000454757.6:c.2233A>T 7:g.55181377A>T EGFR ENST00000275493.6 3633 3236 2522588 2522588 2384907 endometrium NS NS NS carcinoma adenocarcinoma NS NS n COSM5881413 178385455 c.? p.I462M Substitution - Missense + - Variant of unknown origin 27170661 surgery-fixed metastasis 50 EGFR ENST00000275493.6 3633 3236 2345010 2345010 2209682 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2345021 2345021 2209693 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2096279 2096279 1974343 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 2345016 2345016 2209688 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2096281 2096281 1974345 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 2344991 2344991 2209663 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2345122 2345122 2209794 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1965279 1965279 1851774 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 23803047 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1983834 1983834 1870070 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1637248 1637248 1553296 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096196 2096196 1974260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419411 NS NS EGFR ENST00000275493.6 3633 3236 2750885 2750885 2609581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 27086595 surgery-fixed NS 56 EGFR ENST00000275493.6 3633 3236 2345009 2345009 2209681 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077369 1077369 992623 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1879511 1879511 1770013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2549128 2549128 2410583 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2584898 2584898 2446062 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSM6009003 178384840 c.? p.S492R Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Ser492Arg EGFR ENST00000275493.6 3633 3236 2046011 2046011 1926306 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 AC-V10-Tumor-SM-9J465 2584480 2445644 large_intestine anus NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51802062 COSM6008937 99385308 c.659C>T p.S220F Substitution - Missense 38 7:55152576-55152576 + - PATHOGENIC .98424 Variant of unknown origin 27852700 surgery-fixed primary ENSP00000275493.2:p.Ser220Phe ENST00000275493.6:c.659C>T 7:g.55152576C>T EGFR ENST00000275493.6 3633 3236 2000274 2000274 1885172 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM27102 178381922 c.? p.R831H Substitution - Missense + - Variant of unknown origin 23945384 surgery-fixed NS ENSP00000275493.2:p.Arg831His EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891236 1891236 1780605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2479710 2479710 2342456 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891233 1891233 1780602 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 6359 915960 833359 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51807685 COSM13177 99392776 c.2063T>C p.L688P Substitution - Missense 38 7:55173922-55173922 + - PATHOGENIC .97819 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000275493.2:p.Leu688Pro ENST00000275493.6:c.2063T>C 7:g.55173922T>C EGFR ENST00000275493.6 3633 3236 2637592 2637592 2497965 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51826065 COSM6438146 99413249 c.2091A>T p.E697D Substitution - Missense 38 7:55173950-55173950 + - PATHOGENIC .86906 Variant of unknown origin 27105513 surgery-fixed NS ENSP00000275493.2:p.Glu697Asp ENST00000275493.6:c.2091A>T 7:g.55173950A>T EGFR ENST00000275493.6 3633 3236 1059474 1059474 975544 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 17429313 NS NS ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 1059474 1059474 975544 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 17429313 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1135420 1135420 1047984 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1046996 1046996 963227 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862403 2862403 2717589 lung right_lower_lobe NS NS carcinoma adenocarcinoma transformed_to_sarcomatoid_carcinoma NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31561203 surgery - NOS metastasis 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096232 2096232 1974296 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471808 1471808 1395546 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51770642 COSM22992 133209132 c.2026G>A p.G676S Substitution - Missense 38 7:55174020-55174020 + - PATHOGENIC .98289 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000415559.1:p.Gly676Ser ENST00000455089.5:c.2026G>A 7:g.55174020G>A EGFR ENST00000275493.6 3633 3236 2264097 2264097 2131081 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1625791 1625791 1543015 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899351 899351 816963 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1937558 1937558 1824492 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029024 2029024 1910906 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2131914 2131914 2005977 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM3718344 178381671 c.? p.P691T Substitution - Missense + - Variant of unknown origin 24376723 surgery-fixed primary EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226854 2226854 2094589 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51787381 COSM22991 133239380 c.2195T>A p.L732Q Substitution - Missense 38 7:55181339-55181339 + - PATHOGENIC .97894 Variant of unknown origin 24891042 NS NS ENSP00000415559.1:p.Leu732Gln ENST00000455089.5:c.2195T>A 7:g.55181339T>A EGFR ENST00000275493.6 3633 3236 2011147 2011147 1893785 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM219792 178384400 c.? p.D855N Substitution - Missense + - Variant of unknown origin 24002608 surgery - NOS NS ENSP00000275493.2:p.Asp855Asn EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166430 1166430 1078744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773222 COSM28608 133238376 c.2258T>A p.L753H Substitution - Missense het 38 7:55181402-55181402 + - PATHOGENIC .95568 Variant of unknown origin 16870303 surgery - NOS NS 51 ENSP00000415559.1:p.Leu753His ENST00000455089.5:c.2258T>A 7:g.55181402T>A EGFR ENST00000275493.6 3633 3236 BL-17-E51214 2905659 2759915 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864645 COSM9997785 99454822 c.1721G>A p.R574Q Substitution - Missense 38 7:55163822-55163822 + - PATHOGENIC .88204 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000275493.2:p.Arg574Gln ENST00000275493.6:c.1721G>A 7:g.55163822G>A EGFR ENST00000275493.6 3633 3236 2652476 2652476 2512603 breast NS NS NS carcinoma HER-positive_carcinoma NS NS n COSM6503281 178382179 c.? p.V398I Substitution - Missense + - Variant of unknown origin 28750640 surgery-fixed NS ENSP00000275493.2:p.Val398Ile EGFR ENST00000275493.6 3633 3236 1983713 1983713 1869949 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1246697 1246697 1158376 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264265 2264265 2131249 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422796 2422796 2285718 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MBC528 2807307 2664011 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99296827 COSM9120819 133280550 c.2159T>A p.V720E Substitution - Missense 38 7:55181303-55181303 + - PATHOGENIC .97894 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000415559.1:p.Val720Glu ENST00000455089.5:c.2159T>A 7:g.55181303T>A EGFR ENST00000275493.6 3633 3236 2422823 2422823 2285745 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2345109 2345109 2209781 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1469366 1469366 1393105 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1532699 1532699 1455059 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20925915 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996944 1996944 1882153 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20894 178379162 c.? p.A859T Substitution - Missense + - Variant of unknown origin 23912954 fixed - NOS NS 73 ENSP00000275493.2:p.Ala859Thr EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471808 1471808 1395546 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51853427 COSM53230 133268250 c.2462A>G p.E821G Substitution - Missense 38 7:55191846-55191846 + - PATHOGENIC .986 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000415559.1:p.Glu821Gly ENST00000455089.5:c.2462A>G 7:g.55191846A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226855 2226855 2094590 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51853800 COSM4170222 132586460 c.2209_2210delinsAA p.L737N Substitution - Missense 38 7:55181353-55181354 + - Variant of unknown origin 24891042 NS NS ENSP00000395243.3:p.Leu737Asn ENST00000454757.6:c.2209_2210delinsAA 7:g.55181353_55181354delinsAA EGFR ENST00000275493.6 3633 3236 1043856 1043856 960197 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2046041 2046041 1926336 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965846 1965846 1852339 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777292 1777292 1681295 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120936 1120936 1034092 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290952 2290952 2157017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1672460 1672460 1585514 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21729655 surgery-fixed primary 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2584904 2584904 2446068 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSM6009004 178382421 c.? p.K467T Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Lys467Thr EGFR ENST00000275493.6 3633 3236 1166426 1166426 1078740 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51824140 COSM28602 99406665 c.2232C>G p.I744M Substitution - Missense hom 38 7:55174769-55174769 + - PATHOGENIC .97142 Variant of unknown origin 16870303 surgery - NOS NS 55 ENSP00000275493.2:p.Ile744Met ENST00000275493.6:c.2232C>G 7:g.55174769C>G EGFR ENST00000275493.6 3633 3236 1213653 1213653 1125520 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18978556 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-176-tumor 2819069 2675368 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592875 1592875 1513801 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51788476 COSM133180 132563809 c.1951G>A p.G651R Substitution - Missense 38 7:55173945-55173945 + - PATHOGENIC .97714 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000395243.3:p.Gly651Arg ENST00000454757.6:c.1951G>A 7:g.55173945G>A EGFR ENST00000275493.6 3633 3236 2046021 2046021 1926316 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2865249 2865249 2720379 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 29413048 surgery-fixed primary 79 ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594126 1594126 1515050 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724887 surgery fresh/frozen NS 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LIM1215_R1_Cetux 2841367 2696923 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576981 COSM9396333 132600632 c.1338A>G p.I446M Substitution - Missense 38 7:55160313-55160313 + - NEUTRAL .12443 Variant of unknown origin 25623215 cell-line NS ENSP00000395243.3:p.Ile446Met ENST00000454757.6:c.1338A>G 7:g.55160313A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2026268 2026268 1908357 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51807481 COSM1716255 132553158 c.2017C>A p.L673M Substitution - Missense 38 7:55174011-55174011 + - PATHOGENIC .91907 Variant of unknown origin 24040454 surgery-fixed NS ENSP00000395243.3:p.Leu673Met ENST00000454757.6:c.2017C>A 7:g.55174011C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2552058 2552058 2413499 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51788909 COSM5967252 133212211 c.2453G>T p.G818V Substitution - Missense 38 7:55191837-55191837 + - PATHOGENIC .95501 Variant of unknown origin 26517354 surgery-fixed NS ENSP00000415559.1:p.Gly818Val ENST00000455089.5:c.2453G>T 7:g.55191837G>T EGFR ENST00000275493.6 3633 3236 1481243 1481243 1404872 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264296 2264296 2131280 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637244 1637244 1553292 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1054392 1054392 970463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1054392 1054392 970463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777782 COSM6227 133210005 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000415559.1:p.His790Leu ENST00000455089.5:c.2369A>T 7:g.55191753A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1981024 1981024 1867260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166429 1166429 1078743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773237 COSM28609 132578163 c.2281A>G p.K761E Substitution - Missense hom 38 7:55181425-55181425 + - PATHOGENIC .9712 Variant of unknown origin 16870303 surgery - NOS NS 70 ENSP00000395243.3:p.Lys761Glu ENST00000454757.6:c.2281A>G 7:g.55181425A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166429 1166429 1078743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773222 COSM28608 132578158 c.2258T>A p.L753H Substitution - Missense het 38 7:55181402-55181402 + - PATHOGENIC .95568 Variant of unknown origin 16870303 surgery - NOS NS 70 ENSP00000395243.3:p.Leu753His ENST00000454757.6:c.2258T>A 7:g.55181402T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166429 1166429 1078743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773249 COSM28610 132578167 c.2306T>C p.L769P Substitution - Missense hom 38 7:55181450-55181450 + - PATHOGENIC .94523 Variant of unknown origin 16870303 surgery - NOS NS 70 ENSP00000395243.3:p.Leu769Pro ENST00000454757.6:c.2306T>C 7:g.55181450T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MBC032T 2807217 2663921 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99296355 COSM9120806 132606670 c.1520A>C p.N507T Substitution - Missense 38 7:55163756-55163756 + - PATHOGENIC .99524 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000395243.3:p.Asn507Thr ENST00000454757.6:c.1520A>C 7:g.55163756A>C EGFR ENST00000275493.6 3633 3236 1535028 1535028 1457363 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1334744 1334744 1245129 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20401612 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2009149 2009149 1891883 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924337 924337 841112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1857885 1857885 1750375 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1169666 178380438 c.? p.P596L Substitution - Missense + - Variant of unknown origin 23243055 surgery-fixed recurrent ENSP00000275493.2:p.Pro596Leu EGFR ENST00000275493.6 3633 3236 1980077 1980077 1866320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 44 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1083792 1083792 998957 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479942 1479942 1403602 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089117 1089117 1004071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089117 1089117 1004071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631941 1631941 1548811 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2864412 2864412 2719569 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26199566 surgery-fixed NS 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1000058 1000058 917281 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1076404 1076404 991658 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17607119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844338 1844338 1737372 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MBC069T 2807244 2663948 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99296428 COSM9120810 132609339 c.1934A>T p.E645V Substitution - Missense 38 7:55173928-55173928 + - PATHOGENIC .98747 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000395243.3:p.Glu645Val ENST00000454757.6:c.1934A>T 7:g.55173928A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471796 1471796 1395534 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51770794 COSM53213 132563972 c.2469A>T p.E823D Substitution - Missense 38 7:55191853-55191853 + - PATHOGENIC .79152 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000395243.3:p.Glu823Asp ENST00000454757.6:c.2469A>T 7:g.55191853A>T EGFR ENST00000275493.6 3633 3236 1776849 1776849 1680895 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036980 fine needle aspirate primary 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237703 1237703 1149450 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009138 2009138 1891872 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895067 1895067 1783759 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777224 1777224 1681227 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680714 2680714 2539987 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 50 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1981031 1981031 1867267 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 23796143 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2345006 2345006 2209678 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 4979 915961 833360 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51790353 COSM13178 99450942 c.2081C>T p.P694L Substitution - Missense 38 7:55173940-55173940 + - PATHOGENIC .97388 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000275493.2:p.Pro694Leu ENST00000275493.6:c.2081C>T 7:g.55173940C>T EGFR ENST00000275493.6 3633 3236 2345464 2345464 2210136 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2688938 2688938 2547920 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 29245278 surgery - NOS metastasis 59 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1695224 1695224 1603444 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51799102 COSM28513 133215426 c.2215T>C p.S739P Substitution - Missense 38 7:55181359-55181359 + - PATHOGENIC .95834 Variant of unknown origin 22607702 surgery-fixed NS ENSP00000415559.1:p.Ser739Pro ENST00000455089.5:c.2215T>C 7:g.55181359T>C EGFR ENST00000275493.6 3633 3236 24B 2525710 2387898 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1732345 1732345 1638311 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22129360 surgery - NOS primary 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1668660 1668660 1581952 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22523351 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459768 1459768 1383711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 21062932 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1921915 1921915 1809233 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887391 1887391 1777063 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1005356 1005356 922568 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1120937 1120937 1034093 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2167082 2167082 2035396 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51782791 COSM3736992 133204896 c.2171T>C p.V724A Substitution - Missense het 38 7:55181315-55181315 + - PATHOGENIC .97686 Variant of unknown origin 24908064 surgery - NOS NS 58 ENSP00000415559.1:p.Val724Ala ENST00000455089.5:c.2171T>C 7:g.55181315T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110457 1110457 1024335 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067044 1067044 983024 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BC3-1 2824190 2680014 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51801471 COSM53105 133208181 c.2357G>A p.R786H Substitution - Missense 38 7:55191741-55191741 + - PATHOGENIC .96289 Reported in another cancer sample as somatic 31867841 circulating tumour recurrent 43 ENSP00000415559.1:p.Arg786His ENST00000455089.5:c.2357G>A 7:g.55191741G>A EGFR ENST00000275493.6 3633 3236 1891195 1891195 1780564 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1705477 1705477 1613383 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1235142 1235142 1146928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 57 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592877 1592877 1513803 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51807024 COSM41905 132561313 c.1957G>A p.A653T Substitution - Missense 38 7:55173951-55173951 + - PATHOGENIC .96084 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000395243.3:p.Ala653Thr ENST00000454757.6:c.1957G>A 7:g.55173951G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110462 1110462 1024340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1625790 1625790 1543014 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2579691 2579691 2441028 NS NS NS NS malignant_melanoma NS NS NS n COSV51786271 COSM6005743 132598687 c.1973T>A p.L658H Substitution - Missense 38 7:55173967-55173967 + - PATHOGENIC .8277 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000395243.3:p.Leu658His ENST00000454757.6:c.1973T>A 7:g.55173967T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592889 1592889 1513815 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51789815 COSM133185 132563985 c.2051G>A p.G684E Substitution - Missense 38 7:55174723-55174723 + - PATHOGENIC .99879 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000395243.3:p.Gly684Glu ENST00000454757.6:c.2051G>A 7:g.55174723G>A EGFR ENST00000275493.6 3633 3236 1618675 1618675 1537427 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1992093 1992093 1877410 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 77 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1014259 1014259 931433 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983153 983153 898871 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983828 1983828 1870064 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1089135 1089135 1004089 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2626134 2626134 2486546 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51791433 COSM6191492 132604947 c.752_753delinsTT p.P251L Substitution - Missense 38 7:55154150-55154151 + - Variant of unknown origin 26645239 surgery-fixed NS ENSP00000395243.3:p.Pro251Leu ENST00000454757.6:c.752_753delinsTT 7:g.55154150_55154151delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TC71 2294589 2160616 bone NS NS NS Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour NS NS NS y COSV51765987 COSM4587485 133278203 c.3007G>T p.A1003S Substitution - Missense 38 7:55201762-55201762 + - NEUTRAL .47883 Variant of unknown origin 25186949 cell-line NS ENSP00000415559.1:p.Ala1003Ser ENST00000455089.5:c.3007G>T 7:g.55201762G>T EGFR ENST00000275493.6 3633 3236 1599066 1599066 1519553 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22091430 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1105404 1105404 1019317 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18243402 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096134 2096134 1974198 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345121 2345121 2209793 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1777410 1777410 1681413 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029003 2029003 1910885 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S29 1063226 979271 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471797 1471797 1395535 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51849843 COSM53265 132618531 c.2421G>T p.K807N Substitution - Missense 38 7:55191805-55191805 + - PATHOGENIC .94296 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000395243.3:p.Lys807Asn ENST00000454757.6:c.2421G>T 7:g.55191805G>T EGFR ENST00000275493.6 3633 3236 1891256 1891256 1780625 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1672195 1672195 1585383 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21917678 fine needle aspirate NS 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 946829 946829 863352 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51778659 COSM14070 99374271 c.2588G>A p.G863D Substitution - Missense 38 7:55191837-55191837 + - PATHOGENIC .92688 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000275493.2:p.Gly863Asp ENST00000275493.6:c.2588G>A 7:g.55191837G>A EGFR ENST00000275493.6 3633 3236 1838662 1838662 1732763 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618784 1618784 1537536 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22215752 surgery-fixed NS 76 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618784 1618784 1537536 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770527 1770527 1674767 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2033913 2033913 1915362 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24126395 surgery - NOS NS 84 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095901 2095901 1973965 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732608 2732608 2591361 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779091 COSM2155593 133216524 c.953C>T p.T318I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Reported in another cancer sample as somatic 26757882 surgery-fixed primary 57 ENSP00000415559.1:p.Thr318Ile ENST00000455089.5:c.953C>T 7:g.55156614C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CCK-81_R1_Cetux 2841357 2696917 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 133218349 c.1256C>T p.S419L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000415559.1:p.Ser419Leu ENST00000455089.5:c.1256C>T 7:g.55160231C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226899 2226899 2094634 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LU-65 946067 862593 lung NS NS NS carcinoma giant_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1887385 1887385 1777057 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345440 2345440 2210112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1566946 1566946 1488715 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51804843 COSM12429 99380902 c.2573_2574delinsGT p.L858R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 21953075 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573_2574delinsGT 7:g.55191822_55191823delinsGT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 6359 915960 833359 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51807685 COSM13177 133220110 c.1928T>C p.L643P Substitution - Missense 38 7:55173922-55173922 + - PATHOGENIC .97819 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000415559.1:p.Leu643Pro ENST00000455089.5:c.1928T>C 7:g.55173922T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-08-0246-01 1910219 1798510 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51792876 COSM43066 132553290 c.632A>C p.D211A Substitution - Missense hom 38 7:55154030-55154030 + - PATHOGENIC .98125 Variant of unknown origin 329 fresh/frozen - NOS primary 57 ENSP00000395243.3:p.Asp211Ala ENST00000454757.6:c.632A>C 7:g.55154030A>C EGFR ENST00000275493.6 3633 3236 1334742 1334742 1245127 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20401612 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637139 1637139 1553187 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1751717 1751717 1656533 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-02-0116-01 1910165 1798456 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51795519 COSM35822 132618116 c.1654G>C p.A552P Substitution - Missense hom 38 7:55165346-55165346 + - NEUTRAL .2004 Variant of unknown origin 329 fresh/frozen - NOS primary 54 ENSP00000395243.3:p.Ala552Pro ENST00000454757.6:c.1654G>C 7:g.55165346G>C EGFR ENST00000275493.6 3633 3236 1042916 1042916 959257 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618714 1618714 1537466 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 75 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-E51214 2905659 2759915 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864645 COSM9997785 133278663 c.1586G>A p.R529Q Substitution - Missense 38 7:55163822-55163822 + - PATHOGENIC .88204 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000415559.1:p.Arg529Gln ENST00000455089.5:c.1586G>A 7:g.55163822G>A EGFR ENST00000275493.6 3633 3236 1774679 1774679 1678903 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS primary 85 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879517 1879517 1770019 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1715000 1715000 1622579 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22710815 surgery-fixed primary 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1937540 1937540 1824474 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656985 1656985 1571640 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22338650 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 G603L 1513407 1436068 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21498706 cell-line primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 946828 946828 863351 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51804843 COSM12429 99380902 c.2573_2574delinsGT p.L858R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573_2574delinsGT 7:g.55191822_55191823delinsGT EGFR ENST00000275493.6 3633 3236 1575157 1575157 1496598 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1014312 1014312 931486 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891292 1891292 1780661 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1046997 1046997 963228 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2045960 2045960 1926255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345366 2345366 2210038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2509044 2509044 2371379 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 49 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 1618755 1618755 1537507 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618755 1618755 1537507 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230492 1230492 1142306 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM30756 178386019 c.? p.L861F Substitution - Missense + - Variant of unknown origin 19536777 NS NS EGFR ENST00000275493.6 3633 3236 1875685 1875685 1766268 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2672948 2672948 2532452 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM34166 178380439 c.? p.R108K Substitution - Missense + - Reported in another cancer sample as somatic 26191234 surgery-fixed primary ENSP00000275493.2:p.Arg108Lys EGFR ENST00000275493.6 3633 3236 2069149 2069149 1948724 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24346091 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173463 1173463 1085547 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19057271 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777347 1777347 1681350 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937530 1937530 1824464 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2153078 2153078 2022088 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2364031 2364031 2226945 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM30754 178378833 c.? p.L747P Substitution - Missense + - Reported in another cancer sample as somatic 25567908 surgery-fixed NS 48 ENSP00000275493.2:p.Leu747Pro EGFR ENST00000275493.6 3633 3236 2345448 2345448 2210120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2273865 2273865 2140425 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25295096 surgery - NOS primary 30 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1967528 1967528 1854020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23807543 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1141193 1141193 1053641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 18785203 autopsy-fixed NS 76 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166431 1166431 1078745 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51803731 COSM28604 133205257 c.2371C>T p.R791C Substitution - Missense het 38 7:55191755-55191755 + - PATHOGENIC .95213 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 48 ENSP00000415559.1:p.Arg791Cys ENST00000455089.5:c.2371C>T 7:g.55191755C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2616329 2616329 2476815 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26118982 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1996574 1996574 1881783 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23922984 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891274 1891274 1780643 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1587270 1587270 1508441 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 5356 915976 833375 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51794784 COSM13182 99375617 c.2203G>A p.G735S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000275493.2:p.Gly735Ser ENST00000275493.6:c.2203G>A 7:g.55174740G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875336 1875336 1765919 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1333428 1333428 1243902 salivary_gland parotid NS NS carcinoma salivary_duct_carcinoma NS NS n COSV51785879 COSM29274 133237805 c.2119T>C p.S707P Substitution - Missense 38 7:55174791-55174791 + - PATHOGENIC .99066 Variant of unknown origin 20371674 surgery-fixed NS 58 ENSP00000415559.1:p.Ser707Pro ENST00000455089.5:c.2119T>C 7:g.55174791T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 HRA19 2301986 2167269 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51788818 COSM4638027 133212043 c.2825T>G p.M942R Substitution - Missense het 38 7:55201201-55201201 + - PATHOGENIC .99397 Variant of unknown origin 24755471 cell-line NS ENSP00000415559.1:p.Met942Arg ENST00000455089.5:c.2825T>G 7:g.55201201T>G EGFR ENST00000275493.6 3633 3236 2345034 2345034 2209706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2344994 2344994 2209666 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1908804 1908804 1797325 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 23507602 fine needle aspirate metastasis 68 EGFR ENST00000275493.6 3633 3236 1875357 1875357 1765940 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1547776 1547776 1469898 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 fine needle aspirate recurrent 46 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1179651 1179651 1091613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226158 2226158 2093893 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096108 2096108 1974172 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166418 1166418 1078732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51786190 COSM28606 133206377 c.2429A>G p.D810G Substitution - Missense het 38 7:55191813-55191813 + - PATHOGENIC .9858 Variant of unknown origin 16870303 surgery - NOS NS 59 ENSP00000415559.1:p.Asp810Gly ENST00000455089.5:c.2429A>G 7:g.55191813A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 4624 915977 833376 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766268 COSM13183 133205606 c.2090T>C p.V697A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000415559.1:p.Val697Ala ENST00000455089.5:c.2090T>C 7:g.55174762T>C EGFR ENST00000275493.6 3633 3236 1983767 1983767 1870003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2819291 2819291 2675590 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 30711944 pleural effusion recurrent 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591077 1591077 1512193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1517412 1517412 1439796 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21617709 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887418 1887418 1777090 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770662 1770662 1674902 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638753 1638753 1554752 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1445189 1445189 1369432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20682976 surgery - NOS primary 85 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1835516 1835516 1730548 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23242440 NS NS 83 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1047 2491942 2354571 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour borderline NS n COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 26437033 surgery fresh/frozen NS 63 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2841036 2841036 2696596 prostate NS NS NS carcinoma NS NS NS n COSV104576576 COSM9495068 132619973 c.3469C>A p.P1157T Substitution - Missense 38 7:55205588-55205588 + - NEUTRAL .47889 Variant of unknown origin 31874108 surgery-fixed primary ENSP00000395243.3:p.Pro1157Thr ENST00000454757.6:c.3469C>A 7:g.55205588C>A EGFR ENST00000275493.6 3633 3236 1777380 1777380 1681383 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228283 2228283 2096009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096308 2096308 1974372 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1853103 1853103 1745718 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 23313172 surgery-fixed NS 48 ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 1853103 1853103 1745718 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51777782 COSM6227 99381636 c.2504A>T p.H835L Substitution - Missense het 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 23313172 surgery-fixed NS 48 ENSP00000275493.2:p.His835Leu ENST00000275493.6:c.2504A>T 7:g.55191753A>T EGFR ENST00000275493.6 3633 3236 2096216 2096216 1974280 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1981007 1981007 1867245 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23842453 surgery fresh/frozen primary 50 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1981025 1981025 1867261 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2841036 2841036 2696596 prostate NS NS NS carcinoma NS NS NS n COSV104576573 COSM9493957 132619962 c.3458_3459delinsGC p.L1153R Substitution - Missense 38 7:55205577-55205578 + - Variant of unknown origin 31874108 surgery-fixed primary ENSP00000395243.3:p.Leu1153Arg ENST00000454757.6:c.3458_3459delinsGC 7:g.55205577_55205578delinsGC EGFR ENST00000275493.6 3633 3236 2225970 2225970 2093705 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1456555 1456555 1380530 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1842968 1842968 1736216 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264144 2264144 2131128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00196T00196 2857366 2712666 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043858 1043858 960199 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2841036 2841036 2696596 prostate NS NS NS carcinoma NS NS NS n COSV104576574 COSM9495067 132619968 c.3467C>A p.A1156E Substitution - Missense 38 7:55205586-55205586 + - PATHOGENIC .80096 Variant of unknown origin 31874108 surgery-fixed primary ENSP00000395243.3:p.Ala1156Glu ENST00000454757.6:c.3467C>A 7:g.55205586C>A EGFR ENST00000275493.6 3633 3236 1031908 1031908 948699 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17085664 pleural effusion recurrent ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2027800 2027800 1909703 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2153196 2153196 2022206 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862709 2862709 2717872 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226770 2226770 2094505 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51789815 COSM133185 132563985 c.2051G>A p.G684E Substitution - Missense 38 7:55174723-55174723 + - PATHOGENIC .99879 Variant of unknown origin 24891042 NS NS ENSP00000395243.3:p.Gly684Glu ENST00000454757.6:c.2051G>A 7:g.55174723G>A EGFR ENST00000275493.6 3633 3236 2218545 2218545 2086556 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345398 2345398 2210070 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474437 2474437 2337206 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046621 2046621 1926915 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2659806 2659806 2519964 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891220 1891220 1780589 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2045988 2045988 1926283 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 VOA1947 2897843 2752142 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105864361 COSM9970409 132595827 c.835C>T p.R279C Substitution - Missense 38 7:55155910-55155910 + - PATHOGENIC .91299 Variant of unknown origin 31477716 surgery-fixed metastasis 69 ENSP00000395243.3:p.Arg279Cys ENST00000454757.6:c.835C>T 7:g.55155910C>T EGFR ENST00000275493.6 3633 3236 1881895 1881895 1772046 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM1166943 178385114 c.? p.V769L Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 40 ENSP00000275493.2:p.Val769Leu EGFR ENST00000275493.6 3633 3236 1597347 1597347 1517835 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19643949 surgery - NOS NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476832 2476832 2339601 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1777367 1777367 1681370 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1052732 1052732 968803 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51798115 COSM24268 132554988 c.2437_2438delinsAA p.L813K Substitution - Missense 38 7:55191821-55191822 + - Variant of unknown origin 17368623 NS NS ENSP00000395243.3:p.Leu813Lys ENST00000454757.6:c.2437_2438delinsAA 7:g.55191821_55191822delinsAA EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PGBM22 1630920 1547790 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51799872 COSM53266 132588516 c.2030C>T p.A677V Substitution - Missense 38 7:55174024-55174024 + - PATHOGENIC .97625 Variant of unknown origin 22286061 surgery - NOS NS ENSP00000395243.3:p.Ala677Val ENST00000454757.6:c.2030C>T 7:g.55174024C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914803 914803 832252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51806784 COSM12428 132567437 c.1990_1992delinsCAT p.E664H Substitution - Missense 38 7:55173984-55173986 + - Variant of unknown origin 15738541 surgery fresh/frozen recurrent ENSP00000395243.3:p.Glu664His ENST00000454757.6:c.1990_1992delinsCAT 7:g.55173984_55173986delinsCAT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625580 2625580 2485992 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 74 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166426 1166426 1078740 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51824140 COSM28602 133233126 c.2097C>G p.I699M Substitution - Missense hom 38 7:55174769-55174769 + - PATHOGENIC .97142 Variant of unknown origin 16870303 surgery - NOS NS 55 ENSP00000415559.1:p.Ile699Met ENST00000455089.5:c.2097C>G 7:g.55174769C>G EGFR ENST00000275493.6 3633 3236 1965870 1965870 1852363 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2132038 2132038 2006101 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24429877 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014308 1014308 931482 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1078215 1078215 993465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767677 COSM25016 99381289 c.2335G>A p.G779S Substitution - Missense 38 7:55181344-55181344 + - PATHOGENIC .98244 Reported in another cancer sample as somatic 17626639 surgery-fixed metastasis ENSP00000275493.2:p.Gly779Ser ENST00000275493.6:c.2335G>A 7:g.55181344G>A EGFR ENST00000275493.6 3633 3236 1637197 1637197 1553245 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2867742 2867742 2722765 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 25345567 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2226882 2226882 2094617 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897845 897845 815467 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1823854 1823854 1722248 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23212424 surgery-fixed metastasis 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875694 1875694 1766277 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1576792 1576792 1498233 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 surgery - NOS metastasis 56 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1746666 1746666 1651642 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 68 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746666 1746666 1651642 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1140934 1140934 1053382 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448998 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045967 2045967 1926262 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591074 1591074 1512190 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451765 1451765 1375814 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20615575 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1188173 1188173 1100072 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19253367 surgery-fixed primary 43 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1591066 1591066 1512182 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891196 1891196 1780565 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-78-7155-01 1914061 1802343 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51802877 COSM6178050 99457262 c.2702G>T p.G901V Substitution - Missense 38 7:55198717-55198717 + - PATHOGENIC .9948 Variant of unknown origin 417 fresh/frozen - NOS primary 68 ENSP00000275493.2:p.Gly901Val ENST00000275493.6:c.2702G>T 7:g.55198717G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592873 1592873 1513799 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51790353 COSM13178 133274216 c.1946C>T p.P649L Substitution - Missense 38 7:55173940-55173940 + - PATHOGENIC .97388 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000415559.1:p.Pro649Leu ENST00000455089.5:c.1946C>T 7:g.55173940C>T EGFR ENST00000275493.6 3633 3236 MG-061-tumor 2819000 2675299 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1777267 1777267 1681270 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1110728 1110728 1024606 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18325048 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895145 1895145 1783837 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1141330 1141330 1053778 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218533 2218533 2086544 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014260 1014260 931434 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777388 1777388 1681391 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264256 2264256 2131240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1489667 1489667 1412825 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21155184 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1876994 1876994 1767556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879547 1879547 1770049 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2425714 2425714 2288635 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471806 1471806 1395544 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51799872 COSM53266 133250183 c.2030C>T p.A677V Substitution - Missense 38 7:55174024-55174024 + - PATHOGENIC .97625 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000415559.1:p.Ala677Val ENST00000455089.5:c.2030C>T 7:g.55174024C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1884154 1884154 1774041 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1631946 1631946 1548816 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1517072 1517072 1439666 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1967526 1967526 1854018 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23807543 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345407 2345407 2210079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2136678 2136678 2006229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2843208 2843208 2698661 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS n COSV51801471 COSM53105 99379999 c.2492G>A p.R831H Substitution - Missense 38 7:55191741-55191741 + - PATHOGENIC .96289 Reported in another cancer sample as somatic 25302557 blood-bone marrow NS ENSP00000275493.2:p.Arg831His ENST00000275493.6:c.2492G>A 7:g.55191741G>A EGFR ENST00000275493.6 3633 3236 1542171 1542171 1464474 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2432453 2432453 2295354 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25798276 NS NS 81 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2078473 2078473 1957192 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1077341 1077341 992595 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592982 1592982 1513908 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51824363 COSM133206 133217120 c.2395C>G p.L799V Substitution - Missense 38 7:55191779-55191779 + - PATHOGENIC .9686 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu799Val ENST00000455089.5:c.2395C>G 7:g.55191779C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-B0-5116-01 1779843 1683842 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51823166 COSM485465 132559286 c.2990G>A p.S997N Substitution - Missense hom 38 7:55201745-55201745 + - PATHOGENIC .98326 Variant of unknown origin 416 fresh/frozen - NOS primary 52 ENSP00000395243.3:p.Ser997Asn ENST00000454757.6:c.2990G>A 7:g.55201745G>A EGFR ENST00000275493.6 3633 3236 1637066 1637066 1553114 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549131 2549131 2410586 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2822953 2822953 2678812 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 29807405 surgery - NOS recurrent 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2822953 2822953 2678812 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29807405 surgery - NOS recurrent 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422801 2422801 2285723 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1493356 1493356 1416346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469429 1469429 1393168 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1000054 1000054 917277 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618776 1618776 1537528 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 42 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2808101 2808101 2664786 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 31258848 surgery-fixed NS 60 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2046188 2046188 1926483 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1885197 1885197 1775084 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1673289 1673289 1586343 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22225786 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451770 1451770 1375819 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20615575 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 HRA19 2301986 2167269 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51788818 COSM4638027 99383425 c.2960T>G p.M987R Substitution - Missense het 38 7:55201201-55201201 + - PATHOGENIC .99397 Variant of unknown origin 24755471 cell-line NS ENSP00000275493.2:p.Met987Arg ENST00000275493.6:c.2960T>G 7:g.55201201T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239185 2239185 2106717 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 fine needle aspirate NS 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239185 2239185 2106717 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 25130612 fine needle aspirate NS 68 ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2026146 2026146 1908235 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51807481 COSM1716255 132553158 c.2017C>A p.L673M Substitution - Missense 38 7:55174011-55174011 + - PATHOGENIC .91907 Variant of unknown origin 24040454 surgery-fixed NS ENSP00000395243.3:p.Leu673Met ENST00000454757.6:c.2017C>A 7:g.55174011C>A EGFR ENST00000275493.6 3633 3236 1965812 1965812 1852305 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 MM1S 2809756 2666426 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV51776216 COSM1235506 99437799 c.2749G>C p.G917R Substitution - Missense het 38 7:55198764-55198764 + - PATHOGENIC .9843 Variant of unknown origin 30545397 cell-line NS ENSP00000275493.2:p.Gly917Arg ENST00000275493.6:c.2749G>C 7:g.55198764G>C EGFR ENST00000275493.6 3633 3236 2264281 2264281 2131265 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264317 2264317 2131301 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1531512 1531512 1453872 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21681119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246642 1246642 1158321 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493343 1493343 1416333 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1005461 1005461 922673 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51779191 COSM20897 99449667 c.2083A>G p.S695G Substitution - Missense 38 7:55173942-55173942 + - PATHOGENIC .98113 Variant of unknown origin 16822827 fixed - NOS NS 56 ENSP00000275493.2:p.Ser695Gly ENST00000275493.6:c.2083A>G 7:g.55173942A>G EGFR ENST00000275493.6 3633 3236 2345104 2345104 2209776 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1887439 1887439 1777111 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1705476 1705476 1613382 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1000061 1000061 917284 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1173391 1173391 1085475 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551535 1551535 1473640 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230473 1230473 1142287 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345359 2345359 2210031 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891183 1891183 1780552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043126 1043126 959467 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51776999 COSM22949 132577210 c.2450T>C p.L817P Substitution - Missense 38 7:55191834-55191834 + - PATHOGENIC .97782 Variant of unknown origin 17224267 surgery-fixed NS 23 ENSP00000395243.3:p.Leu817Pro ENST00000454757.6:c.2450T>C 7:g.55191834T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1330080 1330080 1240565 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51809790 COSM41665 132552988 c.2366T>C p.V789A Substitution - Missense het 38 7:55191750-55191750 + - PATHOGENIC .97813 Variant of unknown origin 20208477 surgery - NOS NS ENSP00000395243.3:p.Val789Ala ENST00000454757.6:c.2366T>C 7:g.55191750T>C EGFR ENST00000275493.6 3633 3236 1453412 1453412 1377445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1453412 1453412 1377445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1960172 1960172 1846812 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469503 1469503 1393242 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895108 1895108 1783800 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009154 2009154 1891888 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 NPC0001PT00229T00229 2857347 2712647 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1083791 1083791 998956 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1516785 1516785 1439379 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21575212 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1517889 1517889 1440267 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21572125 fine needle aspirate NS 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2595757 2595757 2456633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1531501 1531501 1453861 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 21681119 surgery - NOS NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1531501 1531501 1453861 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 21681119 surgery - NOS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2264169 2264169 2131153 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637159 1637159 1553207 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469411 1469411 1393150 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479082 1479082 1402775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076934 2076934 1955683 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24369725 surgery-fixed recurrent 80 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 MBC067T 2807243 2663947 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99294040 COSM9120802 99392184 c.379G>A p.A127T Substitution - Missense 38 7:55143443-55143443 + - NEUTRAL .01752 Reported in another cancer sample as somatic 31340200 surgery - NOS NS ENSP00000275493.2:p.Ala127Thr ENST00000275493.6:c.379G>A 7:g.55143443G>A EGFR ENST00000275493.6 3633 3236 1983755 1983755 1869991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2147915 2147915 2017058 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 79 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777325 1777325 1681328 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1235136 1235136 1146922 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 65 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2840787 2840787 2696347 prostate NS NS NS carcinoma NS NS NS n COSV51807481 COSM1716255 99380046 c.2152C>A p.L718M Substitution - Missense 38 7:55174011-55174011 + - PATHOGENIC .91907 Variant of unknown origin 31874108 surgery-fixed primary ENSP00000275493.2:p.Leu718Met ENST00000275493.6:c.2152C>A 7:g.55174011C>A EGFR ENST00000275493.6 3633 3236 NSCLC-3 1325797 1236293 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20207772 surgery-fixed NS 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2675683 2675683 2534957 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1097650 1097650 1012311 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471811 1471811 1395549 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51795335 COSM53232 133242193 c.1987A>G p.K663E Substitution - Missense 38 7:55173981-55173981 + - PATHOGENIC .98155 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000415559.1:p.Lys663Glu ENST00000455089.5:c.1987A>G 7:g.55173981A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1202558 1202558 1114444 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2239186 2239186 2106718 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 76 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2264228 2264228 2131212 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345569 2345569 2210241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425754 2425754 2288675 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479097 1479097 1402790 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986173 1986173 1872409 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2064714 2064714 1944791 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1334738 1334738 1245123 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20401612 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1517373 1517373 1439757 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21610522 NS primary 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770730 1770730 1674970 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1110463 1110463 1024341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1881373 1881373 1771524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1235342 178378585 c.? p.L62R Substitution - Missense + - Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000275493.2:p.Leu62Arg EGFR ENST00000275493.6 3633 3236 1881373 1881373 1771524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1542299 1542299 1464602 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081897 2081897 1960319 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081897 2081897 1960319 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345495 2345495 2210167 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2432374 2432374 2295277 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 26473643 surgery fresh/frozen metastasis 59 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2422797 2422797 2285719 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777400 1777400 1681403 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675161 2675161 2534435 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51794723 COSM6849767 133213842 c.2077G>T p.V693F Substitution - Missense 38 7:55174749-55174749 + - PATHOGENIC .99674 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000415559.1:p.Val693Phe ENST00000455089.5:c.2077G>T 7:g.55174749G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2728558 2728558 2587369 cervix NS NS NS carcinoma mesonephric_carcinoma NS NS n COSV51846371 COSM7338932 132591315 c.2783G>A p.R928Q Substitution - Missense 38 7:55200385-55200385 + - PATHOGENIC .99379 Variant of unknown origin 26336887 surgery-fixed primary 51 ENSP00000395243.3:p.Arg928Gln ENST00000454757.6:c.2783G>A 7:g.55200385G>A EGFR ENST00000275493.6 3633 3236 1777315 1777315 1681318 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2672934 2672934 2532449 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1716337 178378584 c.? p.A289V Substitution - Missense + - Variant of unknown origin 26191234 surgery-fixed primary ENSP00000275493.2:p.Ala289Val EGFR ENST00000275493.6 3633 3236 2552464 2552464 2413905 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27553514 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535058 1535058 1457393 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1535058 1535058 1457393 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 920134 920134 837214 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 51 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2867537 2867537 2722577 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 32441866 bronchoalveolar lavage fluid NS 59 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1983770 1983770 1870006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1530995 1530995 1453367 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964337 1964337 1850872 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1637254 1637254 1553302 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1196953 1196953 1108848 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1635903 1635903 1552007 lung NS NS NS carcinoma undifferentiated_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22102479 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1135552 1135552 1048116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 18676761 NS NS 65 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1964314 1964314 1850849 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1029019 1029019 945890 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17075123 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983700 1983700 1869936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983831 1983831 1870067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891173 1891173 1780542 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2206108 2206108 2074341 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24997135 surgery-fixed primary ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1043854 1043854 960195 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618783 1618783 1537535 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875678 1875678 1766261 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1673296 1673296 1586350 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22225786 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345360 2345360 2210032 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329252 1329252 1239737 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2750878 2750878 2609574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27086595 fine needle aspirate NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2156946 2156946 2025921 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS 71 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2345052 2345052 2209724 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2131927 2131927 2005990 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24376723 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1593022 1593022 1513948 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1623721 1623721 1541308 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21615826 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EGCT0002 2490752 2353401 testis NS NS NS germ_cell_tumour seminoma NS NS n COSV51794554 COSM5749111 133213798 c.2555T>C p.V852A Substitution - Missense 38 7:55192830-55192830 + - PATHOGENIC .94427 Variant of unknown origin 26956871 surgery fresh/frozen primary ENSP00000415559.1:p.Val852Ala ENST00000455089.5:c.2555T>C 7:g.55192830T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594589 1594589 1515557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51776191 COSM133565 132559384 c.2252G>A p.G751D Substitution - Missense 38 7:55181396-55181396 + - PATHOGENIC .96481 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000395243.3:p.Gly751Asp ENST00000454757.6:c.2252G>A 7:g.55181396G>A EGFR ENST00000275493.6 3633 3236 1284678 1284678 1195973 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM34156 178382848 c.? p.G779F Substitution - Missense + - Variant of unknown origin 16467085 surgery - NOS NS ENSP00000275493.2:p.Gly779Phe EGFR ENST00000275493.6 3633 3236 2345425 2345425 2210097 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777377 1777377 1681380 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2562087 2562087 2423483 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226913 2226913 2094648 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51845318 COSM214350 99380112 c.2602G>A p.E868K Substitution - Missense 38 7:55191851-55191851 + - PATHOGENIC .98896 Variant of unknown origin 24891042 NS NS ENSP00000275493.2:p.Glu868Lys ENST00000275493.6:c.2602G>A 7:g.55191851G>A EGFR ENST00000275493.6 3633 3236 2264362 2264362 2131346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR ENST00000275493.6 3633 3236 2264370 2264370 2131354 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1484294 1484294 1407920 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51771443 COSM12727 132551202 c.2416G>A p.V806I Substitution - Missense 38 7:55191800-55191800 + - PATHOGENIC .98898 Variant of unknown origin 21266046 surgery-fixed primary 67 ENSP00000395243.3:p.Val806Ile ENST00000454757.6:c.2416G>A 7:g.55191800G>A EGFR ENST00000275493.6 3633 3236 1481249 1481249 1404878 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 TCGA-02-0023-01 1910131 1798422 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 38 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2264348 2264348 2131332 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453422 1453422 1377455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2644150 2644150 2504437 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM34167 178379046 c.? p.G598V Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS ENSP00000275493.2:p.Gly598Val EGFR ENST00000275493.6 3633 3236 1231317 1231317 1143107 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2549134 2549134 2410589 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983752 1983752 1869988 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770720 1770720 1674960 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879501 1879501 1770003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1284674 1284674 1195969 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16467085 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914899 1914899 1802901 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593024 1593024 1513950 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2897034 2897034 2751372 ovary NS NS NS germ_cell_tumour mixed malignant NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 30349318 surgery - NOS NS 34 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469424 1469424 1393163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174332 1174332 1086351 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105835 2105835 1983873 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860419 1860419 1751360 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-05-4410-01 1780064 1684063 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51823181 COSM6110421 99417300 c.1131G>T p.R377S Substitution - Missense 38 7:55156657-55156657 + - NEUTRAL .42615 Variant of unknown origin 417 fresh/frozen - NOS primary 62 ENSP00000275493.2:p.Arg377Ser ENST00000275493.6:c.1131G>T 7:g.55156657G>T EGFR ENST00000275493.6 3633 3236 2218428 2218428 2086439 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25076890 surgery - NOS primary 79 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2046178 2046178 1926473 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1965874 1965874 1852367 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1593014 1593014 1513940 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043870 1043870 960211 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51787381 COSM22991 133239380 c.2195T>A p.L732Q Substitution - Missense 38 7:55181339-55181339 + - PATHOGENIC .97894 Variant of unknown origin 17192902 NS NS ENSP00000415559.1:p.Leu732Gln ENST00000455089.5:c.2195T>A 7:g.55181339T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231311 1231311 1143101 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2113069 2113069 1987330 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51788551 COSM214349 132563820 c.1936C>T p.P646S Substitution - Missense het 38 7:55173930-55173930 + - PATHOGENIC .98279 Variant of unknown origin 24595526 surgery-fixed NS ENSP00000395243.3:p.Pro646Ser ENST00000454757.6:c.1936C>T 7:g.55173930C>T EGFR ENST00000275493.6 3633 3236 1246684 1246684 1158363 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1053132 1053132 969203 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17409961 surgery - NOS NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047762 2047762 1928034 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174297 1174297 1086316 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770750 1770750 1674990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105835 2105835 1983873 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2105835 2105835 1983873 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897822 897822 815444 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2432372 2432372 2295275 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 26473643 surgery fresh/frozen metastasis 56 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891288 1891288 1780657 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2245049 2245049 2112325 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914907 1914907 1802909 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1089599 1089599 1004546 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2898918 2898918 2753189 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS n COSV105863717 COSM9973511 133203791 c.2302T>G p.Y768D Substitution - Missense het 38 7:55181446-55181446 + - PATHOGENIC .71023 Variant of unknown origin 27460089 blood-bone marrow NS ENSP00000415559.1:p.Tyr768Asp ENST00000455089.5:c.2302T>G 7:g.55181446T>G EGFR ENST00000275493.6 3633 3236 1895109 1895109 1783801 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2661743 2661743 2521881 lung right_upper_lobe NS NS carcinoma small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28891180 fine needle aspirate primary 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1140938 1140938 1053386 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448998 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770745 1770745 1674985 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345483 2345483 2210155 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1059470 1059470 975540 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17429313 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1000815 1000815 918038 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 16983123 autopsy - NOS metastasis 53 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2147907 2147907 2017050 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51793006 COSM3727812 99395361 c.2236_2241delinsAATTAT p.E746_L747delinsNY Substitution - Missense 38 7:55174773-55174778 + - Variant of unknown origin 24722155 surgery-fixed metastasis 68 ENSP00000275493.2:p.Glu746_Leu747delinsAsnTyr ENST00000275493.6:c.2236_2241delinsAATTAT 7:g.55174773_55174778delinsAATTAT EGFR ENST00000275493.6 3633 3236 2264183 2264183 2131167 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106542 2106542 1984405 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226918 2226918 2094653 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1675628 1675628 1588508 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22560922 surgery-fixed primary 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 PR-0099 1691496 1599763 prostate NS NS NS carcinoma NS NS NS y COSV51846648 COSM244213 99386285 c.2381C>A p.P794H Substitution - Missense het 38 7:55181390-55181390 + - PATHOGENIC .97291 Reported in another cancer sample as somatic 22610119 surgery fresh/frozen primary 70 ENSP00000275493.2:p.Pro794His ENST00000275493.6:c.2381C>A 7:g.55181390C>A EGFR ENST00000275493.6 3633 3236 2479709 2479709 2342455 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2675410 2675410 2534684 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246648 1246648 1158327 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1592977 1592977 1513903 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 2350422 2350422 2214793 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23357969 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1500142 1500142 1423021 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 920137 920137 837217 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 44 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1475463 1475463 1399162 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM53179 178383575 c.? p.V834L Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Val834Leu EGFR ENST00000275493.6 3633 3236 1475463 1475463 1399162 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770585 1770585 1674825 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887399 1887399 1777071 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011175 2011175 1893813 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179665 1179665 1091627 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924340 924340 841115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1551568 1551568 1473673 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2562094 2562094 2423490 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1931640 1931640 1818930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2047776 2047776 1928048 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179672 1179672 1091634 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875384 1875384 1765967 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471802 1471802 1395540 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51780223 COSM28511 132566687 c.1973T>C p.L658P Substitution - Missense 38 7:55173967-55173967 + - PATHOGENIC .90657 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000395243.3:p.Leu658Pro ENST00000454757.6:c.1973T>C 7:g.55173967T>C EGFR ENST00000275493.6 3633 3236 1992092 1992092 1877409 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 54 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1884052 1884052 1773941 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23495083 fixed - NOS primary ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 H1975 1336879 1247264 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 cell-line NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891333 1891333 1780702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891333 1891333 1780702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1162182 1162182 1074514 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766284 COSM28512 99377567 c.2230A>G p.I744V Substitution - Missense 38 7:55174767-55174767 + - PATHOGENIC .99591 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000275493.2:p.Ile744Val ENST00000275493.6:c.2230A>G 7:g.55174767A>G EGFR ENST00000275493.6 3633 3236 2115448 2115448 1989692 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23915069 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879542 1879542 1770044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2214536 2214536 2082660 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346522 2346522 2211185 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425783 2425783 2288704 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1024770 1024770 941747 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17020982 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729745 1729745 1635716 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21945 178380161 c.? p.V802I Substitution - Missense + - Reported in another cancer sample as somatic 22805266 NS NS ENSP00000275493.2:p.Val802Ile EGFR ENST00000275493.6 3633 3236 1937579 1937579 1824513 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885169 1885169 1775056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 RERF-LC-OK 946065 862591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983747 1983747 1869983 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2579438 2579438 2440775 NS NS NS NS malignant_melanoma NS NS NS n COSV51781415 COSM6005739 133244458 c.326G>A p.G109E Substitution - Missense 38 7:55143390-55143390 + - PATHOGENIC .99562 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000415559.1:p.Gly109Glu ENST00000455089.5:c.326G>A 7:g.55143390G>A EGFR ENST00000275493.6 3633 3236 899357 899357 816969 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 899357 899357 816969 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1444794 1444794 1369037 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469389 1469389 1393128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705489 1705489 1613395 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891277 1891277 1780646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875360 1875360 1765943 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895090 1895090 1783782 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1465905 1465905 1389752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21602 178380317 c.? p.L833V Substitution - Missense + - Variant of unknown origin 20808254 NS NS 55 ENSP00000275493.2:p.Leu833Val EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1054391 1054391 970462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067073 1067073 983053 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 MG-081-tumor 2819015 2675314 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231312 1231312 1143102 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770558 1770558 1674798 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2093908 2093908 1972115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24453288 surgery-fixed NS 67 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2093908 2093908 1972115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24453288 surgery-fixed NS 67 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891180 1891180 1780549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PEN-157 2843148 2698601 skin NS NS NS benign_melanocytic_nevus NS NS NS n COSV104576988 COSM9515585 133222439 c.2581G>A p.E861K Substitution - Missense 38 7:55198731-55198731 + - PATHOGENIC .99414 Variant of unknown origin 27890785 surgery-fixed NS ENSP00000415559.1:p.Glu861Lys ENST00000455089.5:c.2581G>A 7:g.55198731G>A EGFR ENST00000275493.6 3633 3236 2898918 2898918 2753189 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS n COSV105863717 COSM9973511 99375490 c.2437T>G p.Y813D Substitution - Missense het 38 7:55181446-55181446 + - PATHOGENIC .71023 Variant of unknown origin 27460089 blood-bone marrow NS ENSP00000275493.2:p.Tyr813Asp ENST00000275493.6:c.2437T>G 7:g.55181446T>G EGFR ENST00000275493.6 3633 3236 1302281 1302281 1213332 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1844510 1844510 1737544 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23154768 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278400 1278400 1189696 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19596957 autopsy - NOS metastasis 51 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2264168 2264168 2131152 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1994268 1994268 1879523 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23886169 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1983773 1983773 1870009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2240658 2240658 2108189 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2799858 2799858 2656674 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25453846 surgery-fixed primary 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1162202 1162202 1074534 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777242 1777242 1681245 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1695229 1695229 1603449 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765351 COSM53292 99377267 c.2608C>T p.H870Y Substitution - Missense het 38 7:55191857-55191857 + - PATHOGENIC .96355 Reported in another cancer sample as somatic 22607702 surgery-fixed NS ENSP00000275493.2:p.His870Tyr ENST00000275493.6:c.2608C>T 7:g.55191857C>T EGFR ENST00000275493.6 3633 3236 1596618 1596618 1517400 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22071596 blood-bone marrow NS 67 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1493355 1493355 1416345 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2153112 2153112 2022122 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891304 1891304 1780673 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1637212 1637212 1553260 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 899354 899354 816966 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450920 1450920 1375063 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345401 2345401 2210073 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860427 1860427 1751368 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2105796 2105796 1983834 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637634 2637634 2498007 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 81 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2637634 2637634 2498007 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 81 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2778532 2778532 2636586 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51859563 COSM6910210 99376263 c.2509G>A p.D837N Substitution - Missense 38 7:55191758-55191758 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000275493.2:p.Asp837Asn ENST00000275493.6:c.2509G>A 7:g.55191758G>A EGFR ENST00000275493.6 3633 3236 1672473 1672473 1585527 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21729655 surgery-fixed metastasis 68 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675371 2675371 2534645 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51776282 COSM1168015 133202278 c.2123C>T p.P708L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Reported in another cancer sample as somatic 29100434 surgery - NOS recurrent ENSP00000415559.1:p.Pro708Leu ENST00000455089.5:c.2123C>T 7:g.55174795C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2697836 2697836 2556740 breast NS NS NS carcinoma NS NS NS n COSV51788004 COSM6906202 133259542 c.3055A>G p.S1019G Substitution - Missense 38 7:55202544-55202544 + - PATHOGENIC .8902 Variant of unknown origin 29349598 NS NS ENSP00000415559.1:p.Ser1019Gly ENST00000455089.5:c.3055A>G 7:g.55202544A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1992085 1992085 1877402 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 50 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2046614 2046614 1926908 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638741 1638741 1554740 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444772 1444772 1369015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2057657 2057657 1937864 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24255770 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1638723 1638723 1554722 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838640 1838640 1732741 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EBC-1 946069 862595 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1031896 1031896 948687 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 17085664 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1777328 1777328 1681331 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1098873 1098873 1013465 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2426837 2426837 2289758 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2426837 2426837 2289758 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM5010368 178378709 c.? p.C797S Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Cys797Ser EGFR ENST00000275493.6 3633 3236 1593006 1593006 1513932 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2105815 2105815 1983853 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1790526 1790526 1693505 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16152581 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1964338 1964338 1850873 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1169617 178383170 c.? p.L718V Substitution - Missense + - Variant of unknown origin 23749122 NS NS ENSP00000275493.2:p.Leu718Val EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EBC-1 946069 862595 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LPS31 2800466 2657282 soft_tissue fat upper_leg NS liposarcoma myxoid-round_cell NS NS n COSV99286196 COSM9110952 132570912 c.3329C>A p.A1110D Substitution - Missense 38 7:55205448-55205448 + - NEUTRAL .17478 Variant of unknown origin 26643872 surgery - NOS primary 45 ENSP00000395243.3:p.Ala1110Asp ENST00000454757.6:c.3329C>A 7:g.55205448C>A EGFR ENST00000275493.6 3633 3236 5-GE103-T1 2869807 2724804 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51789934 COSM6652266 99392068 c.3176C>T p.P1059L Substitution - Missense 38 7:55202530-55202530 + - PATHOGENIC .92486 Reported in another cancer sample as somatic 26950094 surgery - NOS NS 75 ENSP00000275493.2:p.Pro1059Leu ENST00000275493.6:c.3176C>T 7:g.55202530C>T EGFR ENST00000275493.6 3633 3236 1174334 1174334 1086353 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174334 1174334 1086353 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM28739 178379146 c.? p.D761Y Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Asp761Tyr EGFR ENST00000275493.6 3633 3236 2026267 2026267 1908356 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2474460 2474460 2337229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098817 1098817 1013409 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 132553412 c.2477C>G p.A826G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 18176089 surgery fresh/frozen primary 51 ENSP00000395243.3:p.Ala826Gly ENST00000454757.6:c.2477C>G 7:g.55191861C>G EGFR ENST00000275493.6 3633 3236 BL-18-T40375 2905680 2759936 NS NS NS NS malignant_melanoma NS NS NS n COSV105864578 COSM9994221 99445793 c.3331C>T p.H1111Y Substitution - Missense 38 7:55205315-55205315 + - PATHOGENIC .90556 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000275493.2:p.His1111Tyr ENST00000275493.6:c.3331C>T 7:g.55205315C>T EGFR ENST00000275493.6 3633 3236 2096136 2096136 1974200 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1602812 1602812 1522148 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1885195 1885195 1775082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027816 2027816 1909719 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096015 2096015 1974079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264375 2264375 2131359 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2008972 2008972 1891706 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23979198 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2579678 2579678 2441015 NS NS NS NS malignant_melanoma NS NS NS n COSV51769129 COSM6005742 133224242 c.1666_1667delinsAA p.G556K Substitution - Missense 38 7:55165358-55165359 + - Variant of unknown origin 25148578 surgery-fixed NS ENSP00000415559.1:p.Gly556Lys ENST00000455089.5:c.1666_1667delinsAA 7:g.55165358_55165359delinsAA EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1656008 1656008 1570665 peritoneum NS NS NS mesothelioma NS NS NS n COSV51844929 COSM211635 132600573 c.2413C>T p.H805Y Substitution - Missense het 38 7:55191797-55191797 + - PATHOGENIC .97885 Variant of unknown origin 22426987 surgery-fixed NS 58 ENSP00000395243.3:p.His805Tyr ENST00000454757.6:c.2413C>T 7:g.55191797C>T EGFR ENST00000275493.6 3633 3236 1469346 1469346 1393085 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421204 2421204 2284126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2406805 2406805 2269685 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 56 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2406805 2406805 2269685 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246628 1246628 1158307 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2625559 2625559 2485971 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 99380328 c.2612C>G p.A871G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 27056568 surgery-fixed NS 51 ENSP00000275493.2:p.Ala871Gly ENST00000275493.6:c.2612C>G 7:g.55191861C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2651874 2651874 2512014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27257132 surgery - NOS recurrent 71 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2651874 2651874 2512014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 133213822 c.2018T>A p.L673Q Substitution - Missense hom 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Reported in another cancer sample as somatic 27257132 surgery - NOS recurrent 71 ENSP00000415559.1:p.Leu673Gln ENST00000455089.5:c.2018T>A 7:g.55174012T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2651874 2651874 2512014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 27257132 surgery - NOS recurrent 71 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592991 1592991 1513917 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732913 2732913 2591666 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 133205223 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 60 ENSP00000415559.1:p.Ala244Asp ENST00000455089.5:c.731C>A 7:g.55154129C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1894923 1894923 1783615 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2026149 2026149 1908238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51785295 COSM1716257 132590919 c.2191C>A p.R731S Substitution - Missense het 38 7:55181335-55181335 + - PATHOGENIC .9754 Variant of unknown origin 24040454 surgery-fixed NS ENSP00000395243.3:p.Arg731Ser ENST00000454757.6:c.2191C>A 7:g.55181335C>A EGFR ENST00000275493.6 3633 3236 1097636 1097636 1012297 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637103 1637103 1553151 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046172 2046172 1926467 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2045961 2045961 1926256 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895148 1895148 1783840 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1921732 1921732 1809050 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense hom + - Reported in another cancer sample as somatic 23620765 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1631958 1631958 1548828 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1887417 1887417 1777089 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1107784 1107784 1021687 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2019523 2019523 1901731 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense het + Yes Reported in another cancer sample as somatic 24029120 surgery - NOS recurrent 58 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2908160 2908160 2762334 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 33260286 surgery - NOS metastasis 64 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1837424 1837424 1731623 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM133708 178380057 c.? p.V774M Substitution - Missense + - Variant of unknown origin 23242437 NS NS ENSP00000275493.2:p.Val774Met EGFR ENST00000275493.6 3633 3236 11 1481505 1405134 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21240995 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493350 1493350 1416340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-264-tumor 2819115 2675414 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1885198 1885198 1775085 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1696869 1696869 1604997 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22674612 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551483 1551483 1473588 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS 76 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983834 1983834 1870070 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1074944 1074944 990198 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51811855 COSM24848 132580631 c.2446C>G p.L816V Substitution - Missense 38 7:55191830-55191830 + - PATHOGENIC .93198 Variant of unknown origin 17573511 fine needle aspirate metastasis 67 ENSP00000395243.3:p.Leu816Val ENST00000454757.6:c.2446C>G 7:g.55191830C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592876 1592876 1513802 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51825508 COSM133181 132559233 c.1952G>A p.G651E Substitution - Missense 38 7:55173946-55173946 + - PATHOGENIC .98116 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000395243.3:p.Gly651Glu ENST00000454757.6:c.1952G>A 7:g.55173946G>A EGFR ENST00000275493.6 3633 3236 1879499 1879499 1770001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1875692 1875692 1766275 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1053137 1053137 969208 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17409961 surgery - NOS NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1320608 1320608 1231495 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20159991 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680616 2680616 2539889 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 63 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 911620 911620 829103 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51771443 COSM12727 132551202 c.2416G>A p.V806I Substitution - Missense 38 7:55191800-55191800 + - PATHOGENIC .98898 Variant of unknown origin 15870435 surgery-fixed primary ENSP00000395243.3:p.Val806Ile ENST00000454757.6:c.2416G>A 7:g.55191800G>A EGFR ENST00000275493.6 3633 3236 2581352 2581352 2442607 lung left NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 27923714 surgery - NOS metastasis 42 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1566428 1566428 1488235 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21242665 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965836 1965836 1852329 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 AMO1 2809758 2666428 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasmacytoma NS NS y COSV51777457 COSM1236015 132570365 c.492A>C p.K164N Substitution - Missense het 38 7:55151361-55151361 + - NEUTRAL .14933 Variant of unknown origin 30545397 cell-line NS ENSP00000395243.3:p.Lys164Asn ENST00000454757.6:c.492A>C 7:g.55151361A>C EGFR ENST00000275493.6 3633 3236 2345114 2345114 2209786 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1921942 1921942 1809260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 19 2570191 2431488 skin face NS NS adnexal_tumour other sebaceoma NS n COSV51828226 COSM5991529 133231853 c.2143C>T p.L715F Substitution - Missense 38 7:55174815-55174815 + - PATHOGENIC .89342 Variant of unknown origin 27311873 surgery-fixed NS 71 ENSP00000415559.1:p.Leu715Phe ENST00000455089.5:c.2143C>T 7:g.55174815C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2841043 2841043 2696603 prostate NS NS NS carcinoma NS NS NS n COSV104576883 COSM9496261 132576214 c.3433T>C p.S1145P Substitution - Missense 38 7:55205552-55205552 + - NEUTRAL .06347 Variant of unknown origin 31874108 surgery-fixed primary ENSP00000395243.3:p.Ser1145Pro ENST00000454757.6:c.3433T>C 7:g.55205552T>C EGFR ENST00000275493.6 3633 3236 2344928 2344928 2209600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25678798 surgery - NOS NS 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 MG-116-tumor 2819038 2675337 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1777392 1777392 1681395 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879511 1879511 1770013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NAN8 2809783 2666453 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV99289308 COSM9153923 132572405 c.1918G>C p.E640Q Substitution - Missense het 38 7:55173116-55173116 + - PATHOGENIC .99493 Variant of unknown origin 30545397 cell-line primary ENSP00000395243.3:p.Glu640Gln ENST00000454757.6:c.1918G>C 7:g.55173116G>C EGFR ENST00000275493.6 3633 3236 2148583 2148583 2017713 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1036696 1036696 953453 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17106442 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1355110 1355110 1265205 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214570 2214570 2082694 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214566 2214566 2082690 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1812624 1812624 1711958 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23174717 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665658 2665658 2525367 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28978102 surgery - NOS metastasis 63 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1135420 1135420 1047984 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1046996 1046996 963227 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-78-7147-01 1914054 1802336 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51797369 COSM6178060 132593675 c.1024C>A p.L342M Substitution - Missense 38 7:55156784-55156784 + - PATHOGENIC .85999 Variant of unknown origin 417 fresh/frozen - NOS primary 67 ENSP00000395243.3:p.Leu342Met ENST00000454757.6:c.1024C>A 7:g.55156784C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MBC531 2807310 2664014 breast NS NS NS carcinoma NS NS NS n COSV99286738 COSM9120811 132618560 c.1084A>G p.I362V Substitution - Missense 38 7:55157674-55157674 + - PATHOGENIC .99284 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000395243.3:p.Ile362Val ENST00000454757.6:c.1084A>G 7:g.55157674A>G EGFR ENST00000275493.6 3633 3236 1695226 1695226 1603446 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51769837 COSM249780 99387447 c.2410G>A p.E804K Substitution - Missense 38 7:55181419-55181419 + - PATHOGENIC .97109 Variant of unknown origin 22607702 surgery-fixed NS ENSP00000275493.2:p.Glu804Lys ENST00000275493.6:c.2410G>A 7:g.55181419G>A EGFR ENST00000275493.6 3633 3236 1983784 1983784 1870020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096296 2096296 1974360 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096296 2096296 1974360 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2479704 2479704 2342450 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1592986 1592986 1513912 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1838641 1838641 1732742 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290956 2290956 2157021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MM1S 2809756 2666426 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV51776216 COSM1235506 133260687 c.2614G>C p.G872R Substitution - Missense het 38 7:55198764-55198764 + - PATHOGENIC .9843 Variant of unknown origin 30545397 cell-line NS ENSP00000415559.1:p.Gly872Arg ENST00000455089.5:c.2614G>C 7:g.55198764G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-02-0010-01 1910840 1799125 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779590 COSM35427 133272997 c.1903C>G p.R635G Substitution - Missense het 38 7:55173101-55173101 + - PATHOGENIC .98466 Variant of unknown origin 329 fresh/frozen - NOS primary 22 ENSP00000415559.1:p.Arg635Gly ENST00000455089.5:c.1903C>G 7:g.55173101C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NAN8 2809783 2666453 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV99289304 COSM9153919 132572388 c.535C>T p.R179C Substitution - Missense het 38 7:55152587-55152587 + - PATHOGENIC .90413 Variant of unknown origin 30545397 cell-line primary ENSP00000395243.3:p.Arg179Cys ENST00000454757.6:c.535C>T 7:g.55152587C>T EGFR ENST00000275493.6 3633 3236 1098869 1098869 1013461 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LUAD-RT-S01702 1765245 1669565 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51797291 COSM379422 99424150 c.1897C>T p.L633F Substitution - Missense 38 7:55171191-55171191 + - PATHOGENIC .94672 Variant of unknown origin 22980975 surgery - NOS primary 60 ENSP00000275493.2:p.Leu633Phe ENST00000275493.6:c.1897C>T 7:g.55171191C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 AC-V10-Tumor-SM-9J465 2584480 2445644 large_intestine anus NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51802062 COSM6008937 133213806 c.524C>T p.S175F Substitution - Missense 38 7:55152576-55152576 + - PATHOGENIC .98424 Variant of unknown origin 27852700 surgery-fixed primary ENSP00000415559.1:p.Ser175Phe ENST00000455089.5:c.524C>T 7:g.55152576C>T EGFR ENST00000275493.6 3633 3236 1083061 1083061 998226 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17685931 surgery-fixed NS 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000241 2000241 1885139 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163018 2163018 2031602 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2667845 2667845 2527507 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM6843699 178389322 c.? p.A289T Substitution - Missense + - Reported in another cancer sample as somatic 28663030 surgery-fixed recurrent ENSP00000275493.2:p.Ala289Thr EGFR ENST00000275493.6 3633 3236 1746652 1746652 1651628 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 68 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746652 1746652 1651628 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921900 1921900 1809218 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729751 1729751 1635722 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22805266 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879514 1879514 1770016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1914904 1914904 1802906 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 SA-N101 2521507 2383850 central_nervous_system spinal_cord NS NS glioma astrocytoma_Grade_II fibrillary NS n COSV51785554 COSM21688 99375522 c.971G>T p.R324L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Reported in another cancer sample as somatic 26487540 surgery-fixed NS 82 ENSP00000275493.2:p.Arg324Leu ENST00000275493.6:c.971G>T 7:g.55155911G>T EGFR ENST00000275493.6 3633 3236 2290055 2290055 2156120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 16740761 surgery - NOS NS 81 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1856000 1856000 1748553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345456 2345456 2210128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1625791 1625791 1543015 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899351 899351 816963 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2840788 2840788 2696348 prostate NS NS NS carcinoma NS NS NS n COSV51807481 COSM1716255 133208224 c.2017C>A p.L673M Substitution - Missense 38 7:55174011-55174011 + - PATHOGENIC .91907 Variant of unknown origin 31874108 surgery-fixed metastasis ENSP00000415559.1:p.Leu673Met ENST00000455089.5:c.2017C>A 7:g.55174011C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1333424 1333424 1243898 salivary_gland parotid NS NS carcinoma salivary_duct_carcinoma NS NS n COSV51807685 COSM13177 132563758 c.1928T>C p.L643P Substitution - Missense 38 7:55173922-55173922 + - PATHOGENIC .97819 Variant of unknown origin 20371674 surgery-fixed NS 61 ENSP00000395243.3:p.Leu643Pro ENST00000454757.6:c.1928T>C 7:g.55173922T>C EGFR ENST00000275493.6 3633 3236 1592963 1592963 1513889 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51854311 COSM133198 99392224 c.2243G>A p.R748K Substitution - Missense 38 7:55174780-55174780 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Arg748Lys ENST00000275493.6:c.2243G>A 7:g.55174780G>A EGFR ENST00000275493.6 3633 3236 920129 920129 837209 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2000068 2000068 1884966 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM133708 178380057 c.? p.V774M Substitution - Missense + - Variant of unknown origin 23945384 surgery-fixed NS 74 ENSP00000275493.2:p.Val774Met EGFR ENST00000275493.6 3633 3236 2161443 2161443 2030050 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24852875 surgery - NOS NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587277 1587277 1508448 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045968 2045968 1926263 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591012 1591012 1512128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844330 1844330 1737364 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422828 2422828 2285750 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2226862 2226862 2094597 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469175 1469175 1392914 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21130517 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237670 1237670 1149417 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1631957 1631957 1548827 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983713 1983713 1869949 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2113075 2113075 1987336 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51772282 COSM133202 132556800 c.2201G>A p.G734D Substitution - Missense het 38 7:55181345-55181345 + - PATHOGENIC .98244 Variant of unknown origin 24595526 surgery-fixed NS ENSP00000395243.3:p.Gly734Asp ENST00000454757.6:c.2201G>A 7:g.55181345G>A EGFR ENST00000275493.6 3633 3236 1879500 1879500 1770002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1705524 1705524 1613430 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1705524 1705524 1613430 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638766 1638766 1554765 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1074407 1074407 989661 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17548126 surgery - NOS primary 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591002 1591002 1512118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246661 1246661 1158340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1471796 1471796 1395534 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51770777 COSM28286 99393107 c.2494C>T p.R832C Substitution - Missense 38 7:55191743-55191743 + - PATHOGENIC .95135 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000275493.2:p.Arg832Cys ENST00000275493.6:c.2494C>T 7:g.55191743C>T EGFR ENST00000275493.6 3633 3236 1891170 1891170 1780539 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LUAD-74TBW 1765218 1669538 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51853557 COSM355283 99381834 c.3060G>T p.Q1020H Substitution - Missense 38 7:55201301-55201301 + - PATHOGENIC .88431 Variant of unknown origin 22980975 surgery - NOS primary 73 ENSP00000275493.2:p.Gln1020His ENST00000275493.6:c.3060G>T 7:g.55201301G>T EGFR ENST00000275493.6 3633 3236 1856151 1856151 1748704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 LUAD-NYU252 1765120 1669440 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1882509 1882509 1772645 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51803731 COSM28604 99377260 c.2506C>T p.R836C Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .95213 Reported in another cancer sample as somatic 23486275 NS primary 81 ENSP00000275493.2:p.Arg836Cys ENST00000275493.6:c.2506C>T 7:g.55191755C>T EGFR ENST00000275493.6 3633 3236 1909759 1909759 1798276 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23559152 surgery-fixed NS 64 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2841043 2841043 2696603 prostate NS NS NS carcinoma NS NS NS n COSV104576881 COSM9496259 132576200 c.3406G>A p.A1136T Substitution - Missense 38 7:55205525-55205525 + - .62231 Variant of unknown origin 31874108 surgery-fixed primary ENSP00000395243.3:p.Ala1136Thr ENST00000454757.6:c.3406G>A 7:g.55205525G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2637592 2637592 2497965 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51826065 COSM6438146 133239535 c.1956A>T p.E652D Substitution - Missense 38 7:55173950-55173950 + - PATHOGENIC .86906 Variant of unknown origin 27105513 surgery-fixed NS ENSP00000415559.1:p.Glu652Asp ENST00000455089.5:c.1956A>T 7:g.55173950A>T EGFR ENST00000275493.6 3633 3236 1450924 1450924 1375067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1844349 1844349 1737383 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043856 1043856 960197 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1523089 1523089 1445461 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51813062 COSM12764 132548042 c.2434G>A p.G812R Substitution - Missense het 38 7:55191818-55191818 + - PATHOGENIC .98898 Variant of unknown origin 21284055 surgery-fixed NS ENSP00000395243.3:p.Gly812Arg ENST00000454757.6:c.2434G>A 7:g.55191818G>A EGFR ENST00000275493.6 3633 3236 1429274 1429274 1338725 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770703 1770703 1674943 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965880 1965880 1852373 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983772 1983772 1870008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1154585 1154585 1066921 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18946755 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226893 2226893 2094628 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1110450 1110450 1024328 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1842966 1842966 1736214 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1168014 1168014 1080256 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046065 2046065 1926360 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522889 1522889 1445261 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264227 2264227 2131211 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 11-18R 1890459 1779880 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22773810 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1475405 1475405 1399104 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 975329 975329 891197 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 16410744 surgery-fixed primary ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980077 1980077 1866320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 44 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1996548 1996548 1881757 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 23922984 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 2777955 2777955 2636089 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25982275 surgery - NOS recurrent 34 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2777955 2777955 2636089 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 25982275 surgery - NOS recurrent 34 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2777955 2777955 2636089 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25982275 surgery - NOS recurrent 34 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1891270 1891270 1780639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1196941 1196941 1108836 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-78-7155-01 1914061 1802343 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51802866 COSM1140059 99427144 c.2261A>T p.K754I Substitution - Missense 38 7:55174798-55174798 + - PATHOGENIC .99276 Variant of unknown origin 417 fresh/frozen - NOS primary 68 ENSP00000275493.2:p.Lys754Ile ENST00000275493.6:c.2261A>T 7:g.55174798A>T EGFR ENST00000275493.6 3633 3236 1542152 1542152 1464455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1694967 1694967 1603187 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 82 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1882223 1882223 1772374 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 23392229 surgery-fixed NS ENSP00000275493.2:p.Glu709Ala EGFR ENST00000275493.6 3633 3236 1895102 1895102 1783794 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1083790 1083790 998955 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1855995 1855995 1748548 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 12 1433977 1343392 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1842982 1842982 1736230 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1000058 1000058 917281 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777216 1777216 1681219 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1102461 1102461 1016713 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18202784 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1024778 1024778 941755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17020982 pleural effusion recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 PC-13 946059 862585 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2027799 2027799 1909702 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026222 2026222 1908311 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459517 1459517 1383460 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009149 2009149 1891883 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924337 924337 841112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1479087 1479087 1402780 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1162180 1162180 1074512 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51785698 COSM28510 99426140 c.2162G>C p.G721A Substitution - Missense 38 7:55174021-55174021 + - PATHOGENIC .98515 Variant of unknown origin 19020901 NS NS ENSP00000275493.2:p.Gly721Ala ENST00000275493.6:c.2162G>C 7:g.55174021G>C EGFR ENST00000275493.6 3633 3236 1173405 1173405 1085489 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1188175 1188175 1100074 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19253367 surgery-fixed primary 76 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770721 1770721 1674961 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770526 1770526 1674766 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547809 1547809 1469931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed primary 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1592993 1592993 1513919 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1430040 1430040 1339458 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2688938 2688938 2547920 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 29245278 surgery - NOS metastasis 59 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-78-7158-01 1914062 1802344 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51768921 COSM6178049 133274094 c.2584T>A p.L862M Substitution - Missense 38 7:55198734-55198734 + - NEUTRAL .38059 Variant of unknown origin 417 fresh/frozen - NOS primary 59 ENSP00000415559.1:p.Leu862Met ENST00000455089.5:c.2584T>A 7:g.55198734T>A EGFR ENST00000275493.6 3633 3236 2425721 2425721 2288642 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1136885 1136885 1049449 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51833668 COSM12675 99429874 c.2575G>A p.A859T Substitution - Missense 38 7:55191824-55191824 + - PATHOGENIC .98898 Variant of unknown origin 17580276 surgery-fixed primary ENSP00000275493.2:p.Ala859Thr ENST00000275493.6:c.2575G>A 7:g.55191824G>A EGFR ENST00000275493.6 3633 3236 1136877 1136877 1049441 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1937534 1937534 1824468 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637233 1637233 1553281 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345367 2345367 2210039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469372 1469372 1393111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667707 1667707 1581000 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096057 2096057 1974121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637216 1637216 1553264 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-AP-A051-01 1783330 1687329 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51848796 COSM1090874 99388951 c.1321G>A p.V441I Substitution - Missense het 38 7:55160161-55160161 + - PATHOGENIC .92435 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000275493.2:p.Val441Ile ENST00000275493.6:c.1321G>A 7:g.55160161G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891195 1891195 1780564 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1945218 1945218 1832128 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51769090 COSM1578128 132564039 c.2340G>A p.M780I Substitution - Missense 38 7:55191724-55191724 + - PATHOGENIC .98912 Variant of unknown origin 23295441 surgery-fixed NS ENSP00000395243.3:p.Met780Ile ENST00000454757.6:c.2340G>A 7:g.55191724G>A EGFR ENST00000275493.6 3633 3236 2372596 2372596 2235389 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1668668 1668668 1581960 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22523351 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937524 1937524 1824458 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 S001097 1027690 944666 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 99377226 c.866C>A p.A289D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Ala289Asp ENST00000275493.6:c.866C>A 7:g.55154129C>A EGFR ENST00000275493.6 3633 3236 2672935 2672935 2532449 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1716337 178378584 c.? p.A289V Substitution - Missense + - Variant of unknown origin 26191234 surgery-fixed primary ENSP00000275493.2:p.Ala289Val EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098882 1098882 1013474 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51835641 COSM26436 133275195 c.2399T>C p.V800A Substitution - Missense 38 7:55191783-55191783 + - PATHOGENIC .97813 Variant of unknown origin 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Val800Ala ENST00000455089.5:c.2399T>C 7:g.55191783T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675161 2675161 2534435 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766300 COSM6849765 133205616 c.2102A>G p.E701G Substitution - Missense 38 7:55174774-55174774 + - PATHOGENIC .97324 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000415559.1:p.Glu701Gly ENST00000455089.5:c.2102A>G 7:g.55174774A>G EGFR ENST00000275493.6 3633 3236 1026460 1026460 943436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21622 178382929 c.? p.L858A Substitution - Missense + - Variant of unknown origin 17047654 surgery - NOS NS 56 EGFR ENST00000275493.6 3633 3236 924343 924343 841118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1664609 1664609 1578059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 21899495 pleural effusion NS 54 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2096080 2096080 1974144 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1992093 1992093 1877410 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 77 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983828 1983828 1870064 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089135 1089135 1004089 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 7199 2897738 2752037 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105864119 COSM9964764 132577533 c.3004G>A p.V1002M Substitution - Missense 38 7:55201759-55201759 + - NEUTRAL .28639 Variant of unknown origin 31477716 surgery-fixed metastasis 51 ENSP00000395243.3:p.Val1002Met ENST00000454757.6:c.3004G>A 7:g.55201759G>A EGFR ENST00000275493.6 3633 3236 1585321 1585321 1506642 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22011666 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1097649 1097649 1012310 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005356 1005356 922568 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1566946 1566946 1488715 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51804843 COSM12429 133209145 c.2438_2439delinsGT p.L813R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 21953075 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438_2439delinsGT 7:g.55191822_55191823delinsGT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891256 1891256 1780625 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1672195 1672195 1585383 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21917678 fine needle aspirate NS 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 946829 946829 863352 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51778659 COSM14070 133202857 c.2453G>A p.G818D Substitution - Missense 38 7:55191837-55191837 + - PATHOGENIC .92688 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000415559.1:p.Gly818Asp ENST00000455089.5:c.2453G>A 7:g.55191837G>A EGFR ENST00000275493.6 3633 3236 1308514 1308514 1219459 thyroid NS NS NS carcinoma medullary_carcinoma NS NS n COSM36937 178387356 c.? p.P741H Substitution - Missense + - Variant of unknown origin 19776290 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 921168 921168 838127 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16002952 surgery-fixed primary 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777378 1777378 1681381 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345377 2345377 2210049 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214526 2214526 2082650 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1530994 1530994 1453366 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 911626 911626 829109 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862786 2862786 2717949 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2862786 2862786 2717949 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1751717 1751717 1656533 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096075 2096075 1974139 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451208 1451208 1375351 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042916 1042916 959257 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 946828 946828 863351 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51804843 COSM12429 133209145 c.2438_2439delinsGT p.L813R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438_2439delinsGT 7:g.55191822_55191823delinsGT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1575157 1575157 1496598 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2485527 2485527 2348226 NS NS NS NS malignant_melanoma NS NS NS n COSV51794536 COSM5702630 132548841 c.3272C>T p.P1091L Substitution - Missense 38 7:55205391-55205391 + - PATHOGENIC .96718 Variant of unknown origin 25886620 fixed - NOS NS ENSP00000395243.3:p.Pro1091Leu ENST00000454757.6:c.3272C>T 7:g.55205391C>T EGFR ENST00000275493.6 3633 3236 2822054 2822054 2677914 breast NS NS NS carcinoma NS NS NS n COSM1651572 178381541 c.? p.A750T Substitution - Missense + - Variant of unknown origin 26373574 fixed - NOS NS EGFR ENST00000275493.6 3633 3236 1179110 1179110 1091072 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19185949 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881378 1881378 1771529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1638749 1638749 1554748 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587267 1587267 1508438 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240553 2240553 2108084 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25227801 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891292 1891292 1780661 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891274 1891274 1780643 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1046997 1046997 963228 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2509044 2509044 2371379 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 49 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 1631944 1631944 1548814 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777262 1777262 1681265 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637142 1637142 1553190 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1140935 1140935 1053383 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448998 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105824 2105824 1983862 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875357 1875357 1765940 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345030 2345030 2209702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2345004 2345004 2209676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2344971 2344971 2209643 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1667703 1667703 1580996 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1302293 1302293 1213344 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2009141 2009141 1891875 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2260328 2260328 2127313 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25263855 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895081 1895081 1783773 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879517 1879517 1770019 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1715000 1715000 1622579 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22710815 surgery-fixed primary 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1456555 1456555 1380530 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2498857 2498857 2361208 lung left_upper_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27133750 surgery - NOS metastasis 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895096 1895096 1783788 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453432 1453432 1377465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1631940 1631940 1548810 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1162201 1162201 1074533 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1424057 1424057 1334085 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20595147 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1231322 1231322 1143112 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1921882 1921882 1809200 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179114 1179114 1091076 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19185949 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 914808 914808 832257 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5356 915976 833375 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51794784 COSM13182 133203905 c.2068G>A p.G690S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000415559.1:p.Gly690Ser ENST00000455089.5:c.2068G>A 7:g.55174740G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983767 1983767 1870003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5347 915985 833384 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51867018 COSM13191 132615205 c.2257C>T p.L753F Substitution - Missense 38 7:55181401-55181401 + - PATHOGENIC .94619 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000395243.3:p.Leu753Phe ENST00000454757.6:c.2257C>T 7:g.55181401C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DM10 2466851 2329682 skin face NS NS malignant_melanoma desmoplastic NS NS n COSV51850876 COSM5608334 132562957 c.1222C>T p.L408F Substitution - Missense 38 7:55160197-55160197 + - PATHOGENIC .96542 Variant of unknown origin 26343386 surgery-fixed NS 70 ENSP00000395243.3:p.Leu408Phe ENST00000454757.6:c.1222C>T 7:g.55160197C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2834130 2834130 2689914 skin mucosal anorectal NS malignant_melanoma NS NS NS y COSV104577202 COSM9320357 132577001 c.3487A>T p.I1163F Substitution - Missense 38 7:55205606-55205606 + - PATHOGENIC .94372 Variant of unknown origin 28296713 surgery - NOS primary 59 ENSP00000395243.3:p.Ile1163Phe ENST00000454757.6:c.3487A>T 7:g.55205606A>T EGFR ENST00000275493.6 3633 3236 2525717 2525717 2387905 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1007072 1007072 924280 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51772347 COSM17570 99378871 c.2222C>T p.P741L Substitution - Missense 38 7:55174759-55174759 + - PATHOGENIC .9905 Reported in another cancer sample as somatic 16410744 NS primary ENSP00000275493.2:p.Pro741Leu ENST00000275493.6:c.2222C>T 7:g.55174759C>T EGFR ENST00000275493.6 3633 3236 2157006 2157006 2025981 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881894 1881894 1772045 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 71 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1881894 1881894 1772045 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 71 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2225971 2225971 2093706 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891214 1891214 1780583 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2076979 2076979 1955728 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1498644 1498644 1421522 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21315472 surgery - NOS metastasis 84 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875803 1875803 1766386 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1014307 1014307 931481 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1047975 1047975 964203 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17337084 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1746653 1746653 1651629 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 69 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2476891 2476891 2339660 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226157 2226157 2093892 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1450933 1450933 1375076 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 56 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2078485 2078485 1957204 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1591013 1591013 1512129 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838688 1838688 1732789 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264131 2264131 2131115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659806 2659806 2519964 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1853103 1853103 1745718 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 23313172 surgery-fixed NS 48 ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1853103 1853103 1745718 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51777782 COSM6227 133210005 c.2369A>T p.H790L Substitution - Missense het 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 23313172 surgery-fixed NS 48 ENSP00000415559.1:p.His790Leu ENST00000455089.5:c.2369A>T 7:g.55191753A>T EGFR ENST00000275493.6 3633 3236 1089602 1089602 1004549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2153174 2153174 2022184 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1173393 1173393 1085477 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 ESO-913 1890973 1780342 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV51780707 COSM1251019 99400219 c.3458G>T p.S1153I Substitution - Missense 38 7:55205442-55205442 + - NEUTRAL .36171 Reported in another cancer sample as somatic 23525077 surgery fresh/frozen primary 64 ENSP00000275493.2:p.Ser1153Ile ENST00000275493.6:c.3458G>T 7:g.55205442G>T EGFR ENST00000275493.6 3633 3236 2046615 2046615 1926909 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983112 983112 898830 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027718 2027718 1909621 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1000055 1000055 917278 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1842964 1842964 1736212 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937550 1937550 1824484 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1981025 1981025 1867261 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1031908 1031908 948699 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17085664 pleural effusion recurrent ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1887415 1887415 1777087 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1631955 1631955 1548825 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2625557 2625557 2485969 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1591003 1591003 1512119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 NPC0002PT00040T00040 2857344 2712644 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 BL-16-W43116 2905463 2759719 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51861444 COSM13007 99374834 c.2335_2336delinsTT p.G779F Substitution - Missense 38 7:55181344-55181345 + - Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000275493.2:p.Gly779Phe ENST00000275493.6:c.2335_2336delinsTT 7:g.55181344_55181345delinsTT EGFR ENST00000275493.6 3633 3236 1542154 1542154 1464457 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469801 1469801 1393540 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1637230 1637230 1553278 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891220 1891220 1780589 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2148581 2148581 2017711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1732126 1732126 1638092 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21622214 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 5-WS009-T3 2869941 2724938 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105111008 COSM9808725 99452662 c.3233C>T p.T1078I Substitution - Missense 38 7:55202587-55202587 + - NEUTRAL .10728 Variant of unknown origin 26950094 surgery - NOS NS ENSP00000275493.2:p.Thr1078Ile ENST00000275493.6:c.3233C>T 7:g.55202587C>T EGFR ENST00000275493.6 3633 3236 2096050 2096050 1974114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422802 2422802 2285724 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422802 2422802 2285724 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1078215 1078215 993465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767677 COSM25016 133209614 c.2200G>A p.G734S Substitution - Missense 38 7:55181344-55181344 + - PATHOGENIC .98244 Reported in another cancer sample as somatic 17626639 surgery-fixed metastasis ENSP00000415559.1:p.Gly734Ser ENST00000455089.5:c.2200G>A 7:g.55181344G>A EGFR ENST00000275493.6 3633 3236 2096018 2096018 1974082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 RERF-LC-A1 946074 862600 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1592881 1592881 1513807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-061-tumor 2819000 2675299 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1235134 1235134 1146920 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676414 1676414 1589182 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1860417 1860417 1751358 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1430034 1430034 1339452 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618670 1618670 1537422 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 61 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618670 1618670 1537422 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618786 1618786 1537538 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 56 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618786 1618786 1537538 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029029 2029029 1910911 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2029029 2029029 1910911 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2000196 2000196 1885094 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1077342 1077342 992596 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1676438 1676438 1589206 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1135551 1135551 1048115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18676761 NS NS 52 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732934 2732934 2591687 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51771844 COSM7002278 133214449 c.2806A>C p.I936L Substitution - Missense 38 7:55200408-55200408 + - PATHOGENIC .99358 Variant of unknown origin 28855349 surgery - NOS primary 72 ENSP00000415559.1:p.Ile936Leu ENST00000455089.5:c.2806A>C 7:g.55200408A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226882 2226882 2094617 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897845 897845 815467 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1981010 1981010 1867248 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23842453 surgery fresh/frozen primary 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549144 2549144 2410599 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1531000 1531000 1453372 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 914885 914885 832334 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 15899142 surgery-fixed NS 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838715 1838715 1732816 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1188173 1188173 1100072 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19253367 surgery-fixed primary 43 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891196 1891196 1780565 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302273 1302273 1213324 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1173396 1173396 1085480 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 899349 899349 816961 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1141285 1141285 1053733 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2437218 2437218 2300068 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26469914 NS NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637203 1637203 1553251 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838717 1838717 1732818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1673292 1673292 1586346 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22225786 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218540 2218540 2086551 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625559 2625559 2485971 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 133208531 c.2477C>G p.A826G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 27056568 surgery-fixed NS 51 ENSP00000415559.1:p.Ala826Gly ENST00000455089.5:c.2477C>G 7:g.55191861C>G EGFR ENST00000275493.6 3633 3236 2664358 2664358 2524422 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 57 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469412 1469412 1393151 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2136621 2136621 2006172 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891307 1891307 1780676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1197364 1197364 1109259 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-38-4629-01 1780093 1684092 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51776247 COSM6110417 99392696 c.1393G>A p.G465R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 68 ENSP00000275493.2:p.Gly465Arg ENST00000275493.6:c.1393G>A 7:g.55160233G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1576792 1576792 1498233 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 surgery - NOS metastasis 56 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 MG-209-tumor 2819091 2675390 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2033328 2033328 1914799 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24137465 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345095 2345095 2209767 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 899344 899344 816956 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1312889 1312889 1223798 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19884861 blood-bone marrow NS 66 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895145 1895145 1783837 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1876994 1876994 1767556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879547 1879547 1770049 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2011180 2011180 1893818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2346490 2346490 2211153 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2260332 2260332 2127317 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25263855 fine needle aspirate NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631946 1631946 1548816 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-78-7155-01 1914061 1802343 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51802866 COSM1140059 133250629 c.2126A>T p.K709I Substitution - Missense 38 7:55174798-55174798 + - PATHOGENIC .99276 Variant of unknown origin 417 fresh/frozen - NOS primary 68 ENSP00000415559.1:p.Lys709Ile ENST00000455089.5:c.2126A>T 7:g.55174798A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077341 1077341 992595 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DM16 2466857 2329688 skin head_neck NS NS malignant_melanoma desmoplastic NS NS n COSV51842833 COSM5608338 132590234 c.659C>T p.P220L Substitution - Missense 38 7:55154057-55154057 + - PATHOGENIC .98876 Variant of unknown origin 26343386 surgery-fixed NS 80 ENSP00000395243.3:p.Pro220Leu ENST00000454757.6:c.659C>T 7:g.55154057C>T EGFR ENST00000275493.6 3633 3236 MG-270-tumor 2819119 2675418 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2095995 2095995 1974059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2808101 2808101 2664786 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 31258848 surgery-fixed NS 60 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 MG-194-tumor 2819079 2675378 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2345525 2345525 2210197 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618873 1618873 1537625 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed metastasis 56 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1770719 1770719 1674959 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2372585 2372585 2235378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1637205 1637205 1553253 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986227 1986227 1872463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777385 1777385 1681388 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1839253 1839253 1733354 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51779524 COSM18425 99379336 c.2156G>A p.G719D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Reported in another cancer sample as somatic 23244191 surgery-fixed primary ENSP00000275493.2:p.Gly719Asp ENST00000275493.6:c.2156G>A 7:g.55174015G>A EGFR ENST00000275493.6 3633 3236 2346482 2346482 2211145 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425726 2425726 2288647 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1108049 1108049 1021952 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17973572 surgery - NOS primary 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096132 2096132 1974196 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026264 2026264 1908353 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838674 1838674 1732775 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 924329 924329 841104 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1517072 1517072 1439666 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2843208 2843208 2698661 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS n COSV51801471 COSM53105 133208181 c.2357G>A p.R786H Substitution - Missense 38 7:55191741-55191741 + - PATHOGENIC .96289 Reported in another cancer sample as somatic 25302557 blood-bone marrow NS ENSP00000415559.1:p.Arg786His ENST00000455089.5:c.2357G>A 7:g.55191741G>A EGFR ENST00000275493.6 3633 3236 1618974 1618974 1537696 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 22019513 surgery - NOS NS ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1000061 1000061 917284 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770518 1770518 1674758 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-08-0390-01 1910243 1798534 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 69 ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 TCGA-08-0390-01 1910243 1798534 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51822289 COSM42977 99402277 c.315G>T p.Q105H Substitution - Missense het 38 7:55143379-55143379 + - PATHOGENIC .90579 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 69 ENSP00000275493.2:p.Gln105His ENST00000275493.6:c.315G>T 7:g.55143379G>T EGFR ENST00000275493.6 3633 3236 2476319 2476319 2339087 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 26870223 surgery-fixed metastasis 48 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2476319 2476319 2339087 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 26870223 surgery-fixed metastasis 48 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1083819 1083819 998984 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2482730 2482730 2345457 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26893581 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453412 1453412 1377445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453412 1453412 1377445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983755 1983755 1869991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2147915 2147915 2017058 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 79 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1802323 1802323 1704042 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51802866 COSM1140059 132588903 c.2126A>T p.K709I Substitution - Missense het 38 7:55174798-55174798 + - PATHOGENIC .99276 Variant of unknown origin 23134665 surgery - NOS primary 52 ENSP00000395243.3:p.Lys709Ile ENST00000454757.6:c.2126A>T 7:g.55174798A>T EGFR ENST00000275493.6 3633 3236 2264214 2264214 2131198 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425747 2425747 2288668 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1593008 1593008 1513934 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1075805 1075805 991059 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM24862 178381344 c.? p.I706T Substitution - Missense + - Variant of unknown origin 17575133 fixed - NOS NS EGFR ENST00000275493.6 3633 3236 1246617 1246617 1158296 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MBC067T 2807243 2663947 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99294040 COSM9120802 133219724 c.379G>A p.A127T Substitution - Missense 38 7:55143443-55143443 + - NEUTRAL .01752 Reported in another cancer sample as somatic 31340200 surgery - NOS NS ENSP00000415559.1:p.Ala127Thr ENST00000455089.5:c.379G>A 7:g.55143443G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 4979 915961 833360 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51790353 COSM13178 133274216 c.1946C>T p.P649L Substitution - Missense 38 7:55173940-55173940 + - PATHOGENIC .97388 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000415559.1:p.Pro649Leu ENST00000455089.5:c.1946C>T 7:g.55173940C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732914 2732914 2591667 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827181 COSM7002280 132590450 c.439C>G p.P147A Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .86378 Variant of unknown origin 28855349 surgery - NOS primary 58 ENSP00000395243.3:p.Pro147Ala ENST00000454757.6:c.439C>G 7:g.55151308C>G EGFR ENST00000275493.6 3633 3236 1547780 1547780 1469902 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 59 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1547780 1547780 1469902 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076944 2076944 1955693 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24369725 surgery-fixed metastasis 67 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2076944 2076944 1955693 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed metastasis 67 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110463 1110463 1024341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1881373 1881373 1771524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675683 2675683 2534957 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239186 2239186 2106718 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 76 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2226200 2226200 2093935 lung NS NS NS carcinoma NS NS NS n COSM4170217 178379057 c.? p.K806R Substitution - Missense + - Variant of unknown origin 24924582 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1479924 1479924 1403584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2033580 2033580 1915029 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24137397 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1945217 1945217 1832127 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51782636 COSM85961 99375603 c.2518G>A p.A840T Substitution - Missense 38 7:55191767-55191767 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 23295441 surgery-fixed NS ENSP00000275493.2:p.Ala840Thr ENST00000275493.6:c.2518G>A 7:g.55191767G>A EGFR ENST00000275493.6 3633 3236 1481242 1481242 1404871 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481251 1481251 1404880 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2047764 2047764 1928036 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1103809 1103809 1018061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 AA3-4 2539103 2400692 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25257301 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2432374 2432374 2295277 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 26473643 surgery fresh/frozen metastasis 59 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-78-7155-01 1914061 1802343 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51802828 COSM6178056 133281401 c.1161A>T p.Q387H Substitution - Missense 38 7:55157751-55157751 + - PATHOGENIC .9647 Variant of unknown origin 417 fresh/frozen - NOS primary 68 ENSP00000415559.1:p.Gln387His ENST00000455089.5:c.1161A>T 7:g.55157751A>T EGFR ENST00000275493.6 3633 3236 2264164 2264164 2131148 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00229T00229 2857347 2712647 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983770 1983770 1870006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618064 1618064 1536860 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862731 2862731 2717894 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2240659 2240659 2108190 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770739 1770739 1674979 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1992089 1992089 1877406 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 64 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2579623 2579623 2440960 NS NS NS NS malignant_melanoma NS NS NS n COSV51776282 COSM1168015 99373518 c.2258C>T p.P753L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000275493.2:p.Pro753Leu ENST00000275493.6:c.2258C>T 7:g.55174795C>T EGFR ENST00000275493.6 3633 3236 2046019 2046019 1926314 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1592983 1592983 1513909 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773049 COSM22943 99376120 c.2543C>T p.P848L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Pro848Leu ENST00000275493.6:c.2543C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 1535024 1535024 1457359 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2161698 2161698 2030305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24813888 surgery - NOS recurrent 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770531 1770531 1674771 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881372 1881372 1771523 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2205958 2205958 2074191 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920134 920134 837214 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 51 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1054394 1054394 970465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 2422915 2422915 2285837 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676431 1676431 1589199 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2839892 2839892 2695658 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28961830 circulating tumour recurrent 36 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1110456 1110456 1024334 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593022 1593022 1513948 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064714 2064714 1944791 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983700 1983700 1869936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983831 1983831 1870067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891173 1891173 1780542 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043854 1043854 960195 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897844 897844 815466 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2214553 2214553 2082677 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 NSCLC-15 1325809 1236305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20207772 surgery-fixed NS 82 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163052 2163052 2031636 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1302279 1302279 1213330 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1676439 1676439 1589207 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1573764 1573764 1495233 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21982684 surgery fresh/frozen primary 44 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1937586 1937586 1824520 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549157 2549157 2410612 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777343 1777343 1681346 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046028 2046028 1926323 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618842 1618842 1537594 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 66 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2603444 2603444 2464335 central_nervous_system brain NS NS glioma oligoastrocytoma_Grade_III anaplastic NS n COSM34167 178379046 c.? p.G598V Substitution - Missense + - Reported in another cancer sample as somatic 28042970 surgery-fixed NS 69 ENSP00000275493.2:p.Gly598Val EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-02-0023-01 1910131 1798422 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 38 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231317 1231317 1143107 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983752 1983752 1869988 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777288 1777288 1681291 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770733 1770733 1674973 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838682 1838682 1732783 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879501 1879501 1770003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2897034 2897034 2751372 ovary NS NS NS germ_cell_tumour mixed malignant NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 30349318 surgery - NOS NS 34 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226149 2226149 2093884 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618973 1618973 1537695 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22019513 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345417 2345417 2210089 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777295 1777295 1681298 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1201855 1201855 1113741 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19369630 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2625555 2625555 2485967 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2625555 2625555 2485967 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2218428 2218428 2086439 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25076890 surgery - NOS primary 79 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2273789 2273789 2140349 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25300933 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637134 1637134 1553182 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1097637 1097637 1012298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346527 2346527 2211190 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096304 2096304 1974368 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2096304 2096304 1974368 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774691 1774691 1678915 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS primary 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106535 2106535 1984398 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1575147 1575147 1496588 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1860429 1860429 1751370 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1141299 1141299 1053747 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593014 1593014 1513940 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2626082 2626082 2486494 lung NS NS NS carcinoid-endocrine_tumour typical NS NS n COSV51813933 COSM6191488 132566992 c.2183A>C p.H728P Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98494 Variant of unknown origin 26645239 surgery-fixed NS ENSP00000395243.3:p.His728Pro ENST00000454757.6:c.2183A>C 7:g.55181327A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2585427 2585427 2446591 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51767869 COSM3266583 132551074 c.1216C>T p.R406C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 25623215 surgery - NOS recurrent ENSP00000395243.3:p.Arg406Cys ENST00000454757.6:c.1216C>T 7:g.55160191C>T EGFR ENST00000275493.6 3633 3236 SNU-175 2302007 2167290 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51780766 COSM219795 99373292 c.2591C>T p.A864V Substitution - Missense het 38 7:55191840-55191840 + - PATHOGENIC .93098 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000275493.2:p.Ala864Val ENST00000275493.6:c.2591C>T 7:g.55191840C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895109 1895109 1783801 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1921928 1921928 1809246 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1000815 1000815 918038 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 16983123 autopsy - NOS metastasis 53 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089599 1089599 1004546 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226918 2226918 2094653 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PR-0099 1691496 1599763 prostate NS NS NS carcinoma NS NS NS y COSV51846648 COSM244213 133214685 c.2246C>A p.P749H Substitution - Missense het 38 7:55181390-55181390 + - PATHOGENIC .97291 Reported in another cancer sample as somatic 22610119 surgery fresh/frozen primary 70 ENSP00000415559.1:p.Pro749His ENST00000455089.5:c.2246C>A 7:g.55181390C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2479709 2479709 2342455 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2148582 2148582 2017712 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637193 1637193 1553241 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891222 1891222 1780591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2009144 2009144 1891878 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1141284 1141284 1053732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1059475 1059475 975545 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 17429313 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1059475 1059475 975545 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 17429313 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2105817 2105817 1983855 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1168026 1168026 1080268 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1168026 1168026 1080268 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1991361 1991361 1876696 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis 59 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1162652 1162652 1074984 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19010870 surgery - NOS metastasis 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2422788 2422788 2285710 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469814 1469814 1393553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1498632 1498632 1421510 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21315472 surgery - NOS metastasis 58 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1162966 1162966 1075289 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 18992959 NS recurrent 55 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2665666 2665666 2525375 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28978102 pleural effusion recurrent 71 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2141441 2141441 2010659 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24636848 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1498228 1498228 1421106 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21220471 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1475458 1475458 1399157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618789 1618789 1537541 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 57 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2815053 2815053 2671441 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 29807405 surgery - NOS metastasis 59 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1774672 1774672 1678896 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22993320 surgery - NOS metastasis 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027857 2027857 1909760 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469798 1469798 1393537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2047760 2047760 1928032 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1113049 1113049 1026550 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 18458038 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592977 1592977 1513903 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920137 920137 837217 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 44 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1705528 1705528 1613434 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2595747 2595747 2456623 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2096242 2096242 1974306 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2595756 2595756 2456632 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2345557 2345557 2210229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2107293 2107293 1985156 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966335 1966335 1852828 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2142091 2142091 2011309 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240666 2240666 2108197 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 57 ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1931640 1931640 1818930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875384 1875384 1765967 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891333 1891333 1780702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891333 1891333 1780702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162182 1162182 1074514 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766284 COSM28512 133205611 c.2095A>G p.I699V Substitution - Missense 38 7:55174767-55174767 + - PATHOGENIC .99591 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000415559.1:p.Ile699Val ENST00000455089.5:c.2095A>G 7:g.55174767A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594587 1594587 1515555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772325 COSM133628 132612730 c.2218A>C p.T740P Substitution - Missense 38 7:55181362-55181362 + - PATHOGENIC .91002 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000395243.3:p.Thr740Pro ENST00000454757.6:c.2218A>C 7:g.55181362A>C EGFR ENST00000275493.6 3633 3236 1792582 1792582 1694333 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51779524 COSM18425 99379336 c.2156G>A p.G719D Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .97987 Reported in another cancer sample as somatic 23070249 NS NS 58 ENSP00000275493.2:p.Gly719Asp ENST00000275493.6:c.2156G>A 7:g.55174015G>A EGFR ENST00000275493.6 3633 3236 1141331 1141331 1053779 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1802247 1802247 1703966 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23136191 surgery-fixed NS 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770700 1770700 1674940 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2250001 2250001 2117260 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24646139 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014115 1014115 931289 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014261 1014261 931435 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1992092 1992092 1877409 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 54 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-17-M28272 2905583 2759839 urinary_tract NS NS NS carcinoma transitional_cell_carcinoma NS NS n COSV105864105 COSM9996772 132576662 c.1922G>A p.R641K Substitution - Missense 38 7:55173120-55173120 + - PATHOGENIC .99376 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Arg641Lys ENST00000454757.6:c.1922G>A 7:g.55173120G>A EGFR ENST00000275493.6 3633 3236 1860422 1860422 1751363 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1230483 1230483 1142297 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1230483 1230483 1142297 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1631951 1631951 1548821 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2027865 2027865 1909768 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879542 1879542 1770044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2865247 2865247 2720377 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29413048 surgery-fixed primary 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1213658 1213658 1125525 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18978556 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838698 1838698 1732799 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046050 2046050 1926345 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638756 1638756 1554755 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964306 1964306 1850841 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014319 1014319 931493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1140940 1140940 1053388 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448998 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421169 2421169 2284091 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230478 1230478 1142292 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421171 2421171 2284093 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345368 2345368 2210040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469159 1469159 1392898 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21132006 fixed - NOS NS 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008788 2008788 1891522 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469370 1469370 1393109 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1651678 1651678 1566465 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22420950 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547803 1547803 1469925 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 pleural effusion metastasis 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638771 1638771 1554770 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 27 1596837 1517550 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20093389 surgery fresh/frozen NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1890983 1890983 1780352 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095966 2095966 1974030 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729955 1729955 1635926 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 surgery-fixed NS 82 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264307 2264307 2131291 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346529 2346529 2211192 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402530 2402530 2265386 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469466 1469466 1393205 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921895 1921895 1809213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705493 1705493 1613399 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770637 1770637 1674877 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025399 2025399 1907488 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1795773 1795773 1697521 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23110940 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638730 1638730 1554729 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148601 2148601 2017731 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885194 1885194 1775081 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770565 1770565 1674805 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118422 2118422 1992657 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246640 1246640 1158319 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542349 1542349 1464652 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838650 1838650 1732751 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1076403 1076403 991657 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17607119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459426 1459426 1383369 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20489150 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-081-tumor 2819015 2675314 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1515246 1515246 1437856 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1036700 1036700 953457 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17106442 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637070 1637070 1553118 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983698 1983698 1869934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618789 1618789 1537541 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264354 2264354 2131338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011160 2011160 1893798 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838677 1838677 1732778 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096092 2096092 1974156 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1576806 1576806 1498247 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21921847 surgery - NOS primary 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1076407 1076407 991661 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17607119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2686012 2686012 2545047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045999 2045999 1926294 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2644798 2644798 2505085 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28625641 surgery - NOS recurrent 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1099065 1099065 1013657 lung right_upper_lobe NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18192072 surgery-fixed NS 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264267 2264267 2131251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2426859 2426859 2289780 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2491465 2491465 2354111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26885207 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096118 2096118 1974182 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008976 2008976 1891710 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23979198 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264322 2264322 2131306 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011159 2011159 1893797 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096044 2096044 1974108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000220 2000220 1885118 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587284 1587284 1508455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705528 1705528 1613434 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278186 1278186 1189484 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770571 1770571 1674811 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1355107 1355107 1265202 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899357 899357 816969 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899357 899357 816969 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 WSU-HN30 2296299 2161902 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51845363 COSM4600429 132553652 c.316A>T p.I106F Substitution - Missense 38 7:55143380-55143380 + - PATHOGENIC .97255 Variant of unknown origin 25275298 cell-line NS ENSP00000395243.3:p.Ile106Phe ENST00000454757.6:c.316A>T 7:g.55143380A>T EGFR ENST00000275493.6 3633 3236 1965862 1965862 1852355 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421214 2421214 2284136 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246646 1246646 1158325 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444795 1444795 1369038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1696875 1696875 1605003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22674612 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240666 2240666 2108197 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1963284 1963284 1849832 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23599349 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD42091a 2894825 2749313 skin extremity NS NS malignant_melanoma superficial_spreading NS NS y COSV105110459 COSM9878542 132618366 c.2771C>T p.S924F Substitution - Missense 38 7:55200373-55200373 + - PATHOGENIC .97308 Variant of unknown origin 33024263 surgery-fixed metastasis 57 ENSP00000395243.3:p.Ser924Phe ENST00000454757.6:c.2771C>T 7:g.55200373C>T EGFR ENST00000275493.6 3633 3236 1881915 1881915 1772066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21602 178380317 c.? p.L833V Substitution - Missense + - Variant of unknown origin 23341890 surgery fresh/frozen primary 64 ENSP00000275493.2:p.Leu833Val EGFR ENST00000275493.6 3633 3236 1738890 1738890 1644721 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2069206 2069206 1948781 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24346091 NS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444723 1444723 1368966 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302281 1302281 1213332 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1278400 1278400 1189696 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19596957 autopsy - NOS metastasis 51 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1054399 1054399 970470 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2239170 2239170 2106702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 59 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2239170 2239170 2106702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 59 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1246488 1246488 1158167 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983773 1983773 1870009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1986167 1986167 1872403 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899354 899354 816966 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450920 1450920 1375063 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162202 1162202 1074534 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1695229 1695229 1603449 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765351 COSM53292 133205261 c.2473C>T p.H825Y Substitution - Missense het 38 7:55191857-55191857 + - PATHOGENIC .96355 Reported in another cancer sample as somatic 22607702 surgery-fixed NS ENSP00000415559.1:p.His825Tyr ENST00000455089.5:c.2473C>T 7:g.55191857C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00226T00226 2857365 2712665 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 132574485 c.1027G>A p.D343N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000395243.3:p.Asp343Asn ENST00000454757.6:c.1027G>A 7:g.55156787G>A EGFR ENST00000275493.6 3633 3236 2226141 2226141 2093876 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1671449 1671449 1584651 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22197614 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895158 1895158 1783850 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098873 1098873 1013465 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GTL-16 1945868 1832778 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51809237 COSM18445 132551621 c.3008C>T p.A1003V Substitution - Missense 38 7:55201763-55201763 + - NEUTRAL .41771 Variant of unknown origin 18186519 cell-line NS ENSP00000395243.3:p.Ala1003Val ENST00000454757.6:c.3008C>T 7:g.55201763C>T EGFR ENST00000275493.6 3633 3236 2345572 2345572 2210244 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515256 1515256 1437866 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1530710 1530710 1453082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 21227397 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2344966 2344966 2209638 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2264367 2264367 2131351 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25152623 surgery fresh/frozen NS EGFR ENST00000275493.6 3633 3236 2131892 2131892 2005956 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24419415 NS NS 59 EGFR ENST00000275493.6 3633 3236 2426850 2426850 2289771 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1444766 1444766 1369009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1992207 1992207 1877517 lung left_lower_lobe NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23866929 fine needle aspirate NS 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203079 2203079 2071337 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469813 1469813 1393552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1661849 1661849 1575462 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22487432 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1590993 1590993 1512109 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042854 1042854 959195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766584 COSM12371 132555223 c.1991A>T p.E664V Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97538 Variant of unknown origin 17285735 surgery - NOS NS ENSP00000395243.3:p.Glu664Val ENST00000454757.6:c.1991A>T 7:g.55173985A>T EGFR ENST00000275493.6 3633 3236 BL-18-T40375 2905680 2759936 NS NS NS NS malignant_melanoma NS NS NS n COSV105864576 COSM9994315 99445736 c.1535C>T p.P512L Substitution - Missense 38 7:55161535-55161535 + - NEUTRAL .20165 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Pro512Leu ENST00000275493.6:c.1535C>T 7:g.55161535C>T EGFR ENST00000275493.6 3633 3236 1881381 1881381 1771532 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2057657 2057657 1937864 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24255770 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593006 1593006 1513932 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-15-W23729 2905323 2759579 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51801258 COSM13553 132560226 c.2437_2438inv p.L813R Substitution - Missense 38 7:55191821-55191822 + - Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2437_2438inv 7:g.55191821_55191822inv EGFR ENST00000275493.6 3633 3236 1469410 1469410 1393149 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026151 2026151 1908240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772347 COSM17570 99378871 c.2222C>T p.P741L Substitution - Missense het 38 7:55174759-55174759 + - PATHOGENIC .9905 Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Pro741Leu ENST00000275493.6:c.2222C>T 7:g.55174759C>T EGFR ENST00000275493.6 3633 3236 2027724 2027724 1909627 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 LUAD-RT-S01711 1765173 1669493 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 63 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1729742 1729742 1635713 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM255171 178390311 c.? p.Y764S Substitution - Missense + - Variant of unknown origin 22805266 NS NS EGFR ENST00000275493.6 3633 3236 1734085 1734085 1640034 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22842370 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421220 2421220 2284142 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1790526 1790526 1693505 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16152581 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-GE103-T1 2869807 2724804 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51789934 COSM6652266 133219593 c.3041C>T p.P1014L Substitution - Missense 38 7:55202530-55202530 + - PATHOGENIC .92486 Reported in another cancer sample as somatic 26950094 surgery - NOS NS 75 ENSP00000415559.1:p.Pro1014Leu ENST00000455089.5:c.3041C>T 7:g.55202530C>T EGFR ENST00000275493.6 3633 3236 1667704 1667704 1580997 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011074 2011074 1893712 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2637620 2637620 2497993 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 54 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2290968 2290968 2157033 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2151455 2151455 2020488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24742923 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214576 2214576 2082700 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1914909 1914909 1802911 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778532 2778532 2636586 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51859563 COSM6910210 133204470 c.2374G>A p.D792N Substitution - Missense 38 7:55191758-55191758 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000415559.1:p.Asp792Asn ENST00000455089.5:c.2374G>A 7:g.55191758G>A EGFR ENST00000275493.6 3633 3236 2096161 2096161 1974225 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1837416 1837416 1731615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23242437 NS NS 78 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1837416 1837416 1731615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23242437 NS NS 78 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1734091 1734091 1640040 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22842370 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664339 2664339 2524412 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 67 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1860415 1860415 1751356 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2659799 2659799 2519957 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1052976 1052976 969047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17410005 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602812 1602812 1522148 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-70-6722-01 1783058 1687057 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51807303 COSM747424 132549287 c.2392G>T p.V798L Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .9903 Variant of unknown origin 418 fresh/frozen - NOS primary 47 ENSP00000395243.3:p.Val798Leu ENST00000454757.6:c.2392G>T 7:g.55191776G>T EGFR ENST00000275493.6 3633 3236 1097646 1097646 1012307 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960161 1960161 1846801 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345578 2345578 2210250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046009 2046009 1926304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983694 1983694 1869930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1591040 1591040 1512156 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2644115 2644115 2504402 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1631953 1631953 1548823 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1036628 1036628 953385 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 17201173 NS NS ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226862 2226862 2094597 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777364 1777364 1681367 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921888 1921888 1809206 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895148 1895148 1783840 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631958 1631958 1548828 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2241824 2241824 2109355 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25228365 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014262 1014262 931436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842989 1842989 1736237 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096052 2096052 1974116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680689 2680689 2539962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 40 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 924333 924333 841108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1465896 1465896 1389743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 78 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1465896 1465896 1389743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008801 2008801 1891535 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2008801 2008801 1891535 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1122182 1122182 1035226 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18418018 surgery - NOS NS 47 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879499 1879499 1770001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2664339 2664339 2524412 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921893 1921893 1809211 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 BL-16-X27754 2905540 2759796 gastrointestinal_tract_(site_indeterminate) NS NS NS carcinoma NS NS NS n COSV51789261 COSM12986 99390495 c.2429G>A p.G810D Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98244 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000275493.2:p.Gly810Asp ENST00000275493.6:c.2429G>A 7:g.55181438G>A EGFR ENST00000275493.6 3633 3236 1921894 1921894 1809212 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891191 1891191 1780560 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891315 1891315 1780684 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51779524 COSM18425 99379336 c.2156G>A p.G719D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Gly719Asp ENST00000275493.6:c.2156G>A 7:g.55174015G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1047800 1047800 964029 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51774943 COSM23611 132580976 c.2318G>A p.C773Y Substitution - Missense 38 7:55181462-55181462 + - PATHOGENIC .97439 Variant of unknown origin 17354229 surgery-fixed NS 60 ENSP00000395243.3:p.Cys773Tyr ENST00000454757.6:c.2318G>A 7:g.55181462G>A EGFR ENST00000275493.6 3633 3236 1237696 1237696 1149443 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1990897 1990897 1876232 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-116-tumor 2819038 2675337 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2045983 2045983 1926278 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1481261 1481261 1404890 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 999927 999927 917150 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16785471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1766864 1766864 1671184 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51836814 COSM329081 99416686 c.2201A>G p.E734G Substitution - Missense hom 38 7:55174738-55174738 + - PATHOGENIC .9986 Variant of unknown origin 22422135 surgery - NOS NS ENSP00000275493.2:p.Glu734Gly ENST00000275493.6:c.2201A>G 7:g.55174738A>G EGFR ENST00000275493.6 3633 3236 1592881 1592881 1513807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 1284750 1284750 1196045 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16467085 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142087 2142087 2011305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1456557 1456557 1380532 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1517890 1517890 1440268 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21572125 fine needle aspirate NS 60 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-05-4410-01 1780064 1684063 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51823181 COSM6110421 133242684 c.996G>T p.R332S Substitution - Missense 38 7:55156657-55156657 + - NEUTRAL .42615 Variant of unknown origin 417 fresh/frozen - NOS primary 62 ENSP00000415559.1:p.Arg332Ser ENST00000455089.5:c.996G>T 7:g.55156657G>T EGFR ENST00000275493.6 3633 3236 914811 914811 832260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1566870 1566870 1488677 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21881358 surgery - NOS primary 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046182 2046182 1926477 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 2046608 2046608 1926902 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965814 1965814 1852307 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1516780 1516780 1439374 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21575212 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444734 1444734 1368977 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-86-8055-01 1914088 1802370 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 79 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 H1793 2776325 2634461 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51866889 COSM3266567 132560689 c.797G>T p.C266F Substitution - Missense 38 7:55155872-55155872 + - PATHOGENIC .99418 Variant of unknown origin 29681454 NS NS 52 ENSP00000395243.3:p.Cys266Phe ENST00000454757.6:c.797G>T 7:g.55155872G>T EGFR ENST00000275493.6 3633 3236 2696526 2696526 2555430 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 28201779 surgery fresh/frozen NS 72 ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 2426849 2426849 2289770 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2426849 2426849 2289770 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921906 1921906 1809224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264165 2264165 2131149 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 LU0858 1775134 1679358 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22948846 xenograft NS 35 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1637173 1637173 1553221 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2064708 2064708 1944785 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SA-N101 2521507 2383850 central_nervous_system spinal_cord NS NS glioma astrocytoma_Grade_II fibrillary NS n COSV51785554 COSM21688 133203816 c.836G>T p.R279L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Reported in another cancer sample as somatic 26487540 surgery-fixed NS 82 ENSP00000415559.1:p.Arg279Leu ENST00000455089.5:c.836G>T 7:g.55155911G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2290055 2290055 2156120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 16740761 surgery - NOS NS 81 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1891252 1891252 1780621 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770743 1770743 1674983 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2479704 2479704 2342450 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592986 1592986 1513912 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 NCI-H3255 914952 832399 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15492241 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1625794 1625794 1543018 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2422827 2422827 2285749 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2105808 2105808 1983846 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937581 1937581 1824515 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838721 1838721 1732822 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770701 1770701 1674941 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618667 1618667 1537419 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 81 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618667 1618667 1537419 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 81 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838663 1838663 1732764 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096070 2096070 1974134 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983784 1983784 1870020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2637706 2637706 2498079 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 circulating tumour recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637694 2637694 2498067 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 circulating tumour recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1201381 1201381 1113271 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19357847 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618686 1618686 1537438 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891303 1891303 1780672 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2011183 2011183 1893821 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM26137 178380447 c.? p.T847A Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS EGFR ENST00000275493.6 3633 3236 1453494 1453494 1377527 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879514 1879514 1770016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593034 1593034 1513960 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51770642 COSM22992 132553893 c.2026G>A p.G676S Substitution - Missense 38 7:55174020-55174020 + - PATHOGENIC .98289 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000395243.3:p.Gly676Ser ENST00000454757.6:c.2026G>A 7:g.55174020G>A EGFR ENST00000275493.6 3633 3236 1960171 1960171 1846811 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983708 1983708 1869944 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770741 1770741 1674981 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098869 1098869 1013461 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592963 1592963 1513889 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51854311 COSM133198 133219755 c.2108G>A p.R703K Substitution - Missense 38 7:55174780-55174780 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Arg703Lys ENST00000455089.5:c.2108G>A 7:g.55174780G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920129 920129 837209 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 37 2760145 2618678 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51797913 COSM7339051 132556491 c.2370C>A p.H790Q Substitution - Missense 38 7:55191754-55191754 + - PATHOGENIC .83351 Variant of unknown origin 29876005 surgery-fixed NS ENSP00000395243.3:p.His790Gln ENST00000454757.6:c.2370C>A 7:g.55191754C>A EGFR ENST00000275493.6 3633 3236 2425711 2425711 2288632 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444771 1444771 1369014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734089 1734089 1640038 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22842370 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547800 1547800 1469922 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1467308 1467308 1391154 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20940188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965809 1965809 1852302 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631957 1631957 1548827 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1444751 1444751 1368994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734080 1734080 1640029 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22842370 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2595762 2595762 2456638 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2595762 2595762 2456638 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879500 1879500 1770002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471796 1471796 1395534 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51770777 COSM28286 133220429 c.2359C>T p.R787C Substitution - Missense 38 7:55191743-55191743 + - PATHOGENIC .95135 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000415559.1:p.Arg787Cys ENST00000455089.5:c.2359C>T 7:g.55191743C>T EGFR ENST00000275493.6 3633 3236 2245566 2245566 2112841 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24835218 surgery-fixed recurrent 46 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770554 1770554 1674794 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587287 1587287 1508458 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096027 2096027 1974091 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1295787 1295787 1206859 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692934 surgery - NOS primary 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1026464 1026464 943440 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17047654 surgery - NOS NS 47 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2113076 2113076 1987337 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 24595526 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1479080 1479080 1402773 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891170 1891170 1780539 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-NYU252 1765120 1669440 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1882509 1882509 1772645 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51803731 COSM28604 133205257 c.2371C>T p.R791C Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .95213 Reported in another cancer sample as somatic 23486275 NS primary 81 ENSP00000415559.1:p.Arg791Cys ENST00000455089.5:c.2371C>T 7:g.55191755C>T EGFR ENST00000275493.6 3633 3236 2046053 2046053 1926348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1733679 1733679 1639628 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22836289 surgery-fixed NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081933 2081933 1960355 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24440279 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081904 2081904 1960326 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081904 2081904 1960326 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2595735 2595735 2456611 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS 52 ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450924 1450924 1375067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MM1S 1889512 1778952 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV51776216 COSM1235506 132597110 c.2614G>C p.G872R Substitution - Missense 38 7:55198764-55198764 + - PATHOGENIC .9843 Variant of unknown origin 23396385 cell-line NS ENSP00000395243.3:p.Gly872Arg ENST00000454757.6:c.2614G>C 7:g.55198764G>C EGFR ENST00000275493.6 3633 3236 1894922 1894922 1783614 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1879498 1879498 1770000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2345071 2345071 2209743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1475459 1475459 1399158 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1475459 1475459 1399158 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1465891 1465891 1389738 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1481219 1481219 1404848 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2562100 2562100 2423496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638725 1638725 1554724 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 11 2570179 2431476 skin face NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51775232 COSM5991527 132576002 c.2246C>T p.P749L Substitution - Missense 38 7:55181390-55181390 + - PATHOGENIC .96631 Variant of unknown origin 27311873 surgery-fixed NS 65 ENSP00000395243.3:p.Pro749Leu ENST00000454757.6:c.2246C>T 7:g.55181390C>T EGFR ENST00000275493.6 3633 3236 1026460 1026460 943436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21623 178382931 c.? p.L858W Substitution - Missense + - Variant of unknown origin 17047654 surgery - NOS NS 56 EGFR ENST00000275493.6 3633 3236 1875361 1875361 1765944 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264216 2264216 2131200 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664328 2664328 2524406 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 32 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2664328 2664328 2524406 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 32 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429274 1429274 1338725 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226876 2226876 2094611 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469361 1469361 1393100 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1107783 1107783 1021686 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618763 1618763 1537515 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 72 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1074943 1074943 990197 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1329249 1329249 1239734 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1429293 1429293 1338744 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469468 1469468 1393207 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1592881 1592881 1513807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767280 COSM133183 99392721 c.2142G>C p.K714N Substitution - Missense 38 7:55174001-55174001 + - PATHOGENIC .89357 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Lys714Asn ENST00000275493.6:c.2142G>C 7:g.55174001G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983772 1983772 1870008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 975329 975329 891197 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 16410744 surgery-fixed primary ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226893 2226893 2094628 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110450 1110450 1024328 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2687132 2687132 2546114 breast NS NS NS carcinoma NS NS NS n COSV51783638 COSM28514 132576900 c.2360G>T p.R787L Substitution - Missense 38 7:55191744-55191744 + - PATHOGENIC .96073 Variant of unknown origin 27284958 surgery-fixed metastasis 67 ENSP00000395243.3:p.Arg787Leu ENST00000454757.6:c.2360G>T 7:g.55191744G>T EGFR ENST00000275493.6 3633 3236 1729753 1729753 1635724 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22805266 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1174325 1174325 1086344 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1310472 1310472 1221417 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2033588 2033588 1915037 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24137397 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2482732 2482732 2345459 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26893581 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874742 1874742 1765333 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1435651 1435651 1344930 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20661086 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895129 1895129 1783821 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 11-18R 1890459 1779880 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22773810 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891270 1891270 1780639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1444763 1444763 1369006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076973 2076973 1955722 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed metastasis 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 899320 899320 816932 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1429263 1429263 1338714 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1694967 1694967 1603187 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 82 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1188175 1188175 1100074 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19253367 surgery-fixed primary 76 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2032221 2032221 1913692 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 899339 899339 816951 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 20 1596830 1517543 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20093389 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475386 1475386 1399085 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665714 2665714 2525423 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS recurrent 79 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 12 1433977 1343392 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1530703 1530703 1453075 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21227397 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1587208 1587208 1508379 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1475458 1475458 1399157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1102461 1102461 1016713 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18202784 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895102 1895102 1783794 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2095969 2095969 1974033 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-78-7155-01 1914061 1802343 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51802828 COSM6178056 99457242 c.1296A>T p.Q432H Substitution - Missense 38 7:55157751-55157751 + - PATHOGENIC .9647 Variant of unknown origin 417 fresh/frozen - NOS primary 68 ENSP00000275493.2:p.Gln432His ENST00000275493.6:c.1296A>T 7:g.55157751A>T EGFR ENST00000275493.6 3633 3236 2264351 2264351 2131335 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1077327 1077327 992581 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1113039 1113039 1026540 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18458038 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PC-13 946059 862585 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592874 1592874 1513800 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51790353 COSM13178 132609832 c.1946C>T p.P649L Substitution - Missense 38 7:55173940-55173940 + - PATHOGENIC .97388 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000395243.3:p.Pro649Leu ENST00000454757.6:c.1946C>T 7:g.55173940C>T EGFR ENST00000275493.6 3633 3236 2265098 2265098 2132002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994671 cerebrospinal fluid metastasis 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2432448 2432448 2295349 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25798276 NS NS 88 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1486484 1486484 1410102 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21107288 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2733577 2733577 2592330 central_nervous_system brain NS NS glioma NS NS NS n COSM34166 178380439 c.? p.R108K Substitution - Missense + - Reported in another cancer sample as somatic 29683790 surgery - NOS recurrent ENSP00000275493.2:p.Arg108Lys EGFR ENST00000275493.6 3633 3236 2000273 2000273 1885171 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu861Arg EGFR ENST00000275493.6 3633 3236 1532696 1532696 1455056 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20925915 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1059471 1059471 975541 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17429313 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891169 1891169 1780538 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2562097 2562097 2423493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230481 1230481 1142295 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1230481 1230481 1142295 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2552466 2552466 2413907 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27553514 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542357 1542357 1464660 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592993 1592993 1513919 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1697235 1697235 1605353 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21616658 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2032239 2032239 1913710 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2686016 2686016 2545051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637255 1637255 1553303 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163057 2163057 2031641 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637073 1637073 1553121 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246687 1246687 1158366 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1246687 1246687 1158366 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118437 2118437 1992672 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2350408 2350408 2214779 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 23357969 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136877 1136877 1049441 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166428 1166428 1078742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773237 COSM28609 132578163 c.2281A>G p.K761E Substitution - Missense het 38 7:55181425-55181425 + - PATHOGENIC .9712 Variant of unknown origin 16870303 surgery - NOS NS 67 ENSP00000395243.3:p.Lys761Glu ENST00000454757.6:c.2281A>G 7:g.55181425A>G EGFR ENST00000275493.6 3633 3236 1469426 1469426 1393165 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2115446 2115446 1989690 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23915069 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2471440 2471440 2334227 skin NS NS NS malignant_melanoma NS NS NS n COSV51836136 COSM5574310 99396611 c.2899G>A p.E967K Substitution - Missense 38 7:55200366-55200366 + - PATHOGENIC .99379 Reported in another cancer sample as somatic 25452114 surgery fresh/frozen metastasis 55 ENSP00000275493.2:p.Glu967Lys ENST00000275493.6:c.2899G>A 7:g.55200366G>A EGFR ENST00000275493.6 3633 3236 2482736 2482736 2345463 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26893581 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 11-18-ER2-1 1731374 1637340 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22815900 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1914948 1914948 1802950 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705530 1705530 1613436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1705530 1705530 1613436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1705530 1705530 1613436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 MG-089-tumor 2819020 2675319 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1774668 1774668 1678892 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS metastasis 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179654 1179654 1091616 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372596 2372596 2235389 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1838708 1838708 1732809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879565 1879565 1770067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1526363 1526363 1448731 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21623281 cerebrospinal fluid metastasis 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425743 2425743 2288664 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 897825 897825 815447 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2552467 2552467 2413908 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27553514 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618060 1618060 1536856 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 924291 924291 841066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162180 1162180 1074512 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51785698 COSM28510 133250001 c.2027G>C p.G676A Substitution - Missense 38 7:55174021-55174021 + - PATHOGENIC .98515 Variant of unknown origin 19020901 NS NS ENSP00000415559.1:p.Gly676Ala ENST00000455089.5:c.2027G>C 7:g.55174021G>C EGFR ENST00000275493.6 3633 3236 1489663 1489663 1412821 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21155184 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096251 2096251 1974315 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2426857 2426857 2289778 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1043852 1043852 960193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2141648 2141648 2010866 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24657128 surgery fresh/frozen NS 73 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1770654 1770654 1674894 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1481244 1481244 1404873 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924343 924343 841118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1648526 1648526 1563481 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830809 COSM85993 99415063 c.2260A>G p.K754E Substitution - Missense 38 7:55174797-55174797 + - PATHOGENIC .99211 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000275493.2:p.Lys754Glu ENST00000275493.6:c.2260A>G 7:g.55174797A>G EGFR ENST00000275493.6 3633 3236 1876990 1876990 1767552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345446 2345446 2210118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731386 1731386 1637352 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22457323 NS NS 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444754 1444754 1368997 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179117 1179117 1091079 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19185949 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476880 2476880 2339649 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1110449 1110449 1024327 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096111 2096111 1974175 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459448 1459448 1383391 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1042921 1042921 959262 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 911626 911626 829109 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862786 2862786 2717949 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862786 2862786 2717949 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-05-5423-01 1780079 1684078 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51787416 COSM219794 132554877 c.2364G>T p.L788F Substitution - Missense 38 7:55191748-55191748 + - PATHOGENIC .95793 Variant of unknown origin 417 fresh/frozen - NOS primary 65 ENSP00000395243.3:p.Leu788Phe ENST00000454757.6:c.2364G>T 7:g.55191748G>T EGFR ENST00000275493.6 3633 3236 2345125 2345125 2209797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2595763 2595763 2456639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2595763 2595763 2456639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1075004 1075004 990258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 71 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1336422 1336422 1246807 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20430469 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1451208 1451208 1375351 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2008976 2008976 1891710 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM28739 178379146 c.? p.D761Y Substitution - Missense + - Reported in another cancer sample as somatic 23979198 surgery-fixed NS ENSP00000275493.2:p.Asp761Tyr EGFR ENST00000275493.6 3633 3236 EGCT1088 2490716 2353365 testis NS NS NS germ_cell_tumour choriocarcinoma NS NS n COSV51835294 COSM5749118 99417899 c.1723G>A p.G575R Substitution - Missense 38 7:55165280-55165280 + - PATHOGENIC .99792 Variant of unknown origin 26956871 surgery fresh/frozen primary ENSP00000275493.2:p.Gly575Arg ENST00000275493.6:c.1723G>A 7:g.55165280G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914808 914808 832257 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1007072 1007072 924280 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51772347 COSM17570 133206975 c.2087C>T p.P696L Substitution - Missense 38 7:55174759-55174759 + - PATHOGENIC .9905 Reported in another cancer sample as somatic 16410744 NS primary ENSP00000415559.1:p.Pro696Leu ENST00000455089.5:c.2087C>T 7:g.55174759C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 ESO-721 1890961 1780330 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV51788608 COSM1251016 132563851 c.1205C>A p.S402Y Substitution - Missense 38 7:55160180-55160180 + - .5293 Variant of unknown origin 23525077 surgery fresh/frozen primary 68 ENSP00000395243.3:p.Ser402Tyr ENST00000454757.6:c.1205C>A 7:g.55160180C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-17-J45330 2905663 2759919 NS NS NS NS malignant_melanoma NS NS NS n COSV105864517 COSM9991398 132600667 c.3136G>A p.E1046K Substitution - Missense 38 7:55202625-55202625 + - PATHOGENIC .98023 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Glu1046Lys ENST00000454757.6:c.3136G>A 7:g.55202625G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1523090 1523090 1445462 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51782338 COSM96398 132553086 c.2450T>A p.L817Q Substitution - Missense het 38 7:55191834-55191834 + - PATHOGENIC .98046 Variant of unknown origin 21284055 surgery-fixed NS ENSP00000395243.3:p.Leu817Gln ENST00000454757.6:c.2450T>A 7:g.55191834T>A EGFR ENST00000275493.6 3633 3236 2008792 2008792 1891526 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264186 2264186 2131170 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345584 2345584 2210256 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046032 2046032 1926327 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637127 1637127 1553175 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226191 2226191 2093926 lung NS NS NS carcinoma NS NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631944 1631944 1548814 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302293 1302293 1213344 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1444729 1444729 1368972 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2113068 2113068 1987329 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51767182 COSM27110 99381953 c.2356G>A p.V786M Substitution - Missense 38 7:55181365-55181365 + - PATHOGENIC .97319 Reported in another cancer sample as somatic 24595526 surgery-fixed NS ENSP00000275493.2:p.Val786Met ENST00000275493.6:c.2356G>A 7:g.55181365G>A EGFR ENST00000275493.6 3633 3236 2113068 2113068 1987329 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24595526 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1230463 1230463 1142277 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475457 1475457 1399156 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1965881 1965881 1852374 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1740210 1740210 1645811 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766331 COSM12366 99418284 c.2572C>A p.L858M Substitution - Missense het 38 7:55191821-55191821 + - PATHOGENIC .93782 Reported in another cancer sample as somatic 22836650 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Met ENST00000275493.6:c.2572C>A 7:g.55191821C>A EGFR ENST00000275493.6 3633 3236 1740210 1740210 1645811 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22836650 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2345450 2345450 2210122 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141308 1141308 1053756 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009141 2009141 1891875 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895081 1895081 1783773 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895096 1895096 1783788 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453432 1453432 1377465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2822954 2822954 2678813 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29807405 surgery - NOS recurrent 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475379 1475379 1399078 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680677 2680677 2539950 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1465890 1465890 1389737 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 81 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1881378 1881378 1771529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231322 1231322 1143112 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2027798 2027798 1909701 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2562083 2562083 2423479 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965900 1965900 1852393 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469786 1469786 1393525 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875803 1875803 1766386 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450933 1450933 1375076 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 56 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBC_6 2907852 2762035 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV105864473 COSM10029109 132599603 c.1225A>G p.K409E Substitution - Missense 38 7:55160200-55160200 + - PATHOGENIC .95086 Variant of unknown origin 33563892 surgery-fixed NS 85 ENSP00000395243.3:p.Lys409Glu ENST00000454757.6:c.1225A>G 7:g.55160200A>G EGFR ENST00000275493.6 3633 3236 1576789 1576789 1498230 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 71 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2426838 2426838 2289759 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264303 2264303 2131287 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214533 2214533 2082657 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1000053 1000053 917276 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264149 2264149 2131133 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770595 1770595 1674835 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770698 1770698 1674938 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469854 1469854 1393593 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469854 1469854 1393593 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118450 2118450 1992685 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891214 1891214 1780583 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089602 1089602 1004549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-RT-S01702 1765245 1669565 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51797291 COSM379422 133248439 c.1762C>T p.L588F Substitution - Missense 38 7:55171191-55171191 + - PATHOGENIC .94672 Variant of unknown origin 22980975 surgery - NOS primary 60 ENSP00000415559.1:p.Leu588Phe ENST00000455089.5:c.1762C>T 7:g.55171191C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631940 1631940 1548810 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162201 1162201 1074533 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778588 2778588 2636642 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51773889 COSM14069 132579420 c.2213C>T p.T738I Substitution - Missense 38 7:55181357-55181357 + - PATHOGENIC .96109 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000395243.3:p.Thr738Ile ENST00000454757.6:c.2213C>T 7:g.55181357C>T EGFR ENST00000275493.6 3633 3236 1838672 1838672 1732773 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2009142 2009142 1891876 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2733534 2733534 2592287 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 29704676 surgery - NOS recurrent 36 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-16-W43116 2905463 2759719 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51861444 COSM13007 133203258 c.2200_2201delinsTT p.G734F Substitution - Missense 38 7:55181344-55181345 + - Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000415559.1:p.Gly734Phe ENST00000455089.5:c.2200_2201delinsTT 7:g.55181344_55181345delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1000055 1000055 917278 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625557 2625557 2485969 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0002PT00040T00040 2857344 2712644 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2011163 2011163 1893801 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983692 1983692 1869928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LIM1215_R5_Cetux 2841371 2696923 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51776247 COSM6110417 99392696 c.1393G>A p.G465R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000275493.2:p.Gly465Arg ENST00000275493.6:c.1393G>A 7:g.55160233G>A EGFR ENST00000275493.6 3633 3236 2264229 2264229 2131213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1506756 1506756 1429625 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 21422421 surgery - NOS metastasis 89 ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 1506756 1506756 1429625 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51777782 COSM6227 99381636 c.2504A>T p.H835L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 21422421 surgery - NOS metastasis 89 ENSP00000275493.2:p.His835Leu ENST00000275493.6:c.2504A>T 7:g.55191753A>T EGFR ENST00000275493.6 3633 3236 1998741 1998741 1883813 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 23937608 surgery-fixed primary 88 ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 2000177 2000177 1885075 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547757 1547757 1469879 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed metastasis 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895075 1895075 1783767 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345498 2345498 2210170 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083063 1083063 998228 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17685931 surgery-fixed NS 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2651872 2651872 2512012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27257132 surgery - NOS primary 71 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2033331 2033331 1914802 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24137465 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914941 1914941 1802943 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1660246 1660246 1574519 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21411993 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631955 1631955 1548825 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1732081 1732081 1638047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21622214 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1558195 1558195 1479566 skin NS NS NS malignant_melanoma nodular NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 21176117 surgery-fixed NS 72 ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077342 1077342 992596 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-209-tumor 2819091 2675390 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2000237 2000237 1885135 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425784 2425784 2288705 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM26411 178380422 c.? p.S720F Substitution - Missense + - Variant of unknown origin 23724098 surgery-fixed NS ENSP00000275493.2:p.Ser720Phe EGFR ENST00000275493.6 3633 3236 1891298 1891298 1780667 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1592885 1592885 1513811 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765252 COSM13009 99400543 c.2126A>G p.E709G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Glu709Gly ENST00000275493.6:c.2126A>G 7:g.55173985A>G EGFR ENST00000275493.6 3633 3236 2264191 2264191 2131175 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729732 1729732 1635703 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM20847 178389584 c.? p.L718P Substitution - Missense + - Reported in another cancer sample as somatic 22805266 NS NS ENSP00000275493.2:p.Leu718Pro EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302273 1302273 1213324 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860417 1860417 1751358 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 946830 946830 863353 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51866933 COSM14071 132611669 c.2554G>A p.V852I Substitution - Missense 38 7:55192829-55192829 + - PATHOGENIC .96332 Variant of unknown origin 16204011 surgery-fixed NS ENSP00000395243.3:p.Val852Ile ENST00000454757.6:c.2554G>A 7:g.55192829G>A EGFR ENST00000275493.6 3633 3236 2346534 2346534 2211197 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2009160 2009160 1891894 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1113038 1113038 1026539 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18458038 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874751 1874751 1765342 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095963 2095963 1974027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899349 899349 816961 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2148596 2148596 2017726 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095907 2095907 1973971 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1876992 1876992 1767554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875801 1875801 1766384 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1475392 1475392 1399091 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891307 1891307 1780676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1197364 1197364 1109259 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-194-tumor 2819079 2675378 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1542239 1542239 1464542 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21784628 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1141323 1141323 1053771 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402525 2402525 2265381 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1042913 1042913 959254 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1909757 1909757 1798274 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23559152 surgery-fixed NS 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881915 1881915 1772066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM133107 178380316 c.? p.H835L Substitution - Missense + - Variant of unknown origin 23341890 surgery fresh/frozen primary 64 ENSP00000275493.2:p.His835Leu EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-38-4629-01 1780093 1684092 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51776247 COSM6110417 133220044 c.1258G>A p.G420R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 68 ENSP00000415559.1:p.Gly420Arg ENST00000455089.5:c.1258G>A 7:g.55160233G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899344 899344 816956 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1593007 1593007 1513933 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1014324 1014324 931498 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1235625 1235625 1147388 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19584155 surgery-fixed metastasis 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542350 1542350 1464653 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891231 1891231 1780600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1465889 1465889 1389736 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 83 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-270-tumor 2819119 2675418 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2664595 2664595 2524649 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 28840008 surgery-fixed NS 59 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2477016 2477016 2339785 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25355724 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2625599 2625599 2486011 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 44 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2509057 2509057 2371392 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51783296 COSM5878511 99428943 c.661G>T p.G221W Substitution - Missense 38 7:55152578-55152578 + - NEUTRAL .4823 Variant of unknown origin 26919320 surgery - NOS NS 43 ENSP00000275493.2:p.Gly221Trp ENST00000275493.6:c.661G>T 7:g.55152578G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-74TBW 1765218 1669538 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51853557 COSM355283 133210173 c.2925G>T p.Q975H Substitution - Missense 38 7:55201301-55201301 + - PATHOGENIC .88431 Variant of unknown origin 22980975 surgery - NOS primary 73 ENSP00000415559.1:p.Gln975His ENST00000455089.5:c.2925G>T 7:g.55201301G>T EGFR ENST00000275493.6 3633 3236 2644125 2644125 2504412 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1237680 1237680 1149427 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1108049 1108049 1021952 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17973572 surgery - NOS primary 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1196955 1196955 1108850 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1103802 1103802 1018054 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18271876 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1246723 1246723 1158402 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1067072 1067072 983052 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875349 1875349 1765932 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2840787 2840787 2696347 prostate NS NS NS carcinoma NS NS NS n COSV51807481 COSM1716255 133208224 c.2017C>A p.L673M Substitution - Missense 38 7:55174011-55174011 + - PATHOGENIC .91907 Variant of unknown origin 31874108 surgery-fixed primary ENSP00000415559.1:p.Leu673Met ENST00000455089.5:c.2017C>A 7:g.55174011C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372585 2372585 2235378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-95-7947-01 1914103 1802385 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51819886 COSM6178068 132556918 c.271A>G p.I91V Substitution - Missense 38 7:55143335-55143335 + - PATHOGENIC .98845 Variant of unknown origin 417 fresh/frozen - NOS primary 67 ENSP00000395243.3:p.Ile91Val ENST00000454757.6:c.271A>G 7:g.55143335A>G EGFR ENST00000275493.6 3633 3236 2680501 2680501 2539774 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226771 2226771 2094506 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51795632 COSM26509 99395627 c.2227G>A p.A743T Substitution - Missense 38 7:55174764-55174764 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Ala743Thr ENST00000275493.6:c.2227G>A 7:g.55174764G>A EGFR ENST00000275493.6 3633 3236 2148618 2148618 2017748 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2239173 2239173 2106705 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 70 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593008 1593008 1513934 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592983 1592983 1513909 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773049 COSM22943 133204348 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Pro803Leu ENST00000455089.5:c.2408C>T 7:g.55191792C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2161698 2161698 2030305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24813888 surgery - NOS recurrent 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1839253 1839253 1733354 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51779524 COSM18425 133207486 c.2021G>A p.G674D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Reported in another cancer sample as somatic 23244191 surgery-fixed primary ENSP00000415559.1:p.Gly674Asp ENST00000455089.5:c.2021G>A 7:g.55174015G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2 2557184 2418609 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51828150 COSM5976431 132552372 c.1420G>A p.E474K Substitution - Missense 38 7:55161555-55161555 + - PATHOGENIC .8557 Variant of unknown origin 26934577 surgery fresh/frozen NS ENSP00000395243.3:p.Glu474Lys ENST00000454757.6:c.1420G>A 7:g.55161555G>A EGFR ENST00000275493.6 3633 3236 2264359 2264359 2131343 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1029011 1029011 945882 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17075123 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2136673 2136673 2006224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1122168 1122168 1035212 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 18379370 pleural effusion recurrent 72 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1122168 1122168 1035212 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18379370 pleural effusion recurrent 72 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924329 924329 841104 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-08-0390-01 1910243 1798534 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51822289 COSM42977 133227861 c.315G>T p.Q105H Substitution - Missense het 38 7:55143379-55143379 + - PATHOGENIC .90579 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 69 ENSP00000415559.1:p.Gln105His ENST00000455089.5:c.315G>T 7:g.55143379G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-08-0390-01 1910243 1798534 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 69 ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2476319 2476319 2339087 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 26870223 surgery-fixed metastasis 48 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2476319 2476319 2339087 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 26870223 surgery-fixed metastasis 48 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1891330 1891330 1780699 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1965832 1965832 1852325 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095993 2095993 1974057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1532697 1532697 1455057 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20925915 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000170 2000170 1885068 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425717 2425717 2288638 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422779 2422779 2285701 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228308 2228308 2096022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1896951 1896951 1785638 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23542356 surgery-fixed recurrent 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1746680 1746680 1651656 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 50 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862731 2862731 2717894 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1992089 1992089 1877406 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 64 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2579623 2579623 2440960 NS NS NS NS malignant_melanoma NS NS NS n COSV51776282 COSM1168015 133202278 c.2123C>T p.P708L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000415559.1:p.Pro708Leu ENST00000455089.5:c.2123C>T 7:g.55174795C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897801 897801 815423 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51806784 COSM12428 132567437 c.1990_1992delinsCAT p.E664H Substitution - Missense 38 7:55173984-55173986 + - Variant of unknown origin 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Glu664His ENST00000454757.6:c.1990_1992delinsCAT 7:g.55173984_55173986delinsCAT EGFR ENST00000275493.6 3633 3236 2644140 2644140 2504427 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2644140 2644140 2504427 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1469451 1469451 1393190 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025397 2025397 1907486 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1881372 1881372 1771523 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1591071 1591071 1512187 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618635 1618635 1537387 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 75 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2205985 2205985 2074218 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1638722 1638722 1554721 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046044 2046044 1926339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1067042 1067042 983022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479924 1479924 1403584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1945217 1945217 1832127 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51782636 COSM85961 133203897 c.2383G>A p.A795T Substitution - Missense 38 7:55191767-55191767 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 23295441 surgery-fixed NS ENSP00000415559.1:p.Ala795Thr ENST00000455089.5:c.2383G>A 7:g.55191767G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103809 1103809 1018061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897844 897844 815466 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302279 1302279 1213330 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2422805 2422805 2285727 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21603 178379091 c.? p.R776H Substitution - Missense + - Variant of unknown origin 25456362 NS NS ENSP00000275493.2:p.Arg776His EGFR ENST00000275493.6 3633 3236 2402519 2402519 2265375 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345074 2345074 2209746 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1498200 1498200 1421078 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21220471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1573764 1573764 1495233 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21982684 surgery fresh/frozen primary 44 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2065006 2065006 1945083 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2148600 2148600 2017730 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110456 1110456 1024334 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-RT-S01711 1765173 1669493 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 63 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1752342 1752342 1657153 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22912354 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637135 1637135 1553183 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174299 1174299 1086318 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551561 1551561 1473666 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM30753 178379234 c.? p.E709V Substitution - Missense + - Variant of unknown origin 21858063 surgery-fixed NS ENSP00000275493.2:p.Glu709Val EGFR ENST00000275493.6 3633 3236 2345075 2345075 2209747 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1885174 1885174 1775061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1877567 1877567 1768128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23408463 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096079 2096079 1974143 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1043867 1043867 960208 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1469807 1469807 1393546 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 983143 983143 898861 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887442 1887442 1777114 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345510 2345510 2210182 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1201855 1201855 1113741 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19369630 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625555 2625555 2485967 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625555 2625555 2485967 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1575147 1575147 1496588 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860429 1860429 1751370 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2595739 2595739 2456615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS 69 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1965815 1965815 1852308 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203107 2203107 2071365 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591009 1591009 1512125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 MG-189-tumor 2819075 2675374 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1284676 1284676 1195971 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 16467085 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1777257 1777257 1681260 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SNU-175 2302007 2167290 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51780766 COSM219795 133202085 c.2456C>T p.A819V Substitution - Missense het 38 7:55191840-55191840 + - PATHOGENIC .93098 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000415559.1:p.Ala819Val ENST00000455089.5:c.2456C>T 7:g.55191840C>T EGFR ENST00000275493.6 3633 3236 2142053 2142053 2011271 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 50 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1738936 1738936 1644767 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770636 1770636 1674876 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1043872 1043872 960213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 99396060 c.2281G>T p.D761Y Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99554 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Asp761Tyr ENST00000275493.6:c.2281G>T 7:g.55174818G>T EGFR ENST00000275493.6 3633 3236 1043872 1043872 960213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862120 2862120 2717322 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862120 2862120 2717322 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1777253 1777253 1681256 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345372 2345372 2210044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587283 1587283 1508454 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402482 2402482 2265338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 82 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1695226 1695226 1603446 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51769837 COSM249780 133215601 c.2275G>A p.E759K Substitution - Missense 38 7:55181419-55181419 + - PATHOGENIC .97109 Variant of unknown origin 22607702 surgery-fixed NS ENSP00000415559.1:p.Glu759Lys ENST00000455089.5:c.2275G>A 7:g.55181419G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009144 2009144 1891878 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1139185 1139185 1051749 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51772314 COSM27568 132552042 c.2252G>C p.G751A Substitution - Missense het 38 7:55181396-55181396 + - PATHOGENIC .95257 Variant of unknown origin 17695517 surgery - NOS recurrent 63 ENSP00000395243.3:p.Gly751Ala ENST00000454757.6:c.2252G>C 7:g.55181396G>C EGFR ENST00000275493.6 3633 3236 2402482 2402482 2265338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 82 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879515 1879515 1770017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2095979 2095979 1974043 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1001553 1001553 918776 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15851406 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 BL-14-F34521 2905527 2759783 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51836288 COSM6348843 99408048 c.2342G>T p.C781F Substitution - Missense 38 7:55181351-55181351 + - PATHOGENIC .98402 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000275493.2:p.Cys781Phe ENST00000275493.6:c.2342G>T 7:g.55181351G>T EGFR ENST00000275493.6 3633 3236 2205988 2205988 2074221 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2406842 2406842 2269722 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777223 1777223 1681226 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1450848 1450848 1374991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 57 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777229 1777229 1681232 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279046 1279046 1190342 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed primary 49 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1168026 1168026 1080268 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1168026 1168026 1080268 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1991361 1991361 1876696 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis 59 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162652 1162652 1074984 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19010870 surgery - NOS metastasis 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891222 1891222 1780591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2906654 2906654 2760905 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29616327 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1593003 1593003 1513929 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1816945 1816945 1716113 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1355120 1355120 1265215 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1856200 1856200 1748753 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS metastasis ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1493348 1493348 1416338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476868 2476868 2339637 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2476868 2476868 2339637 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549152 2549152 2410607 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983139 983139 898857 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1792582 1792582 1694333 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51779524 COSM18425 133207486 c.2021G>A p.G674D Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .97987 Reported in another cancer sample as somatic 23070249 NS NS 58 ENSP00000415559.1:p.Gly674Asp ENST00000455089.5:c.2021G>A 7:g.55174015G>A EGFR ENST00000275493.6 3633 3236 1575148 1575148 1496589 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895069 1895069 1783761 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1098867 1098867 1013459 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862723 2862723 2717886 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2840306 2840306 2695866 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 RERF-LC-A1 946074 862600 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1631947 1631947 1548817 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895095 1895095 1783787 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1594595 1594595 1515563 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1637198 1637198 1553246 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1974003 1974003 1860245 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1246654 1246654 1158333 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860422 1860422 1751363 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631951 1631951 1548821 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1484342 1484342 1407968 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 99375118 c.2252C>T p.T751I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Reported in another cancer sample as somatic 21266046 surgery-fixed primary 64 ENSP00000275493.2:p.Thr751Ile ENST00000275493.6:c.2252C>T 7:g.55174789C>T EGFR ENST00000275493.6 3633 3236 1429264 1429264 1338715 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1965877 1965877 1852370 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1310477 1310477 1221422 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899352 899352 816964 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983764 1983764 1870000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098867 1098867 1013459 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895095 1895095 1783787 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453426 1453426 1377459 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1575148 1575148 1496589 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895118 1895118 1783810 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453416 1453416 1377449 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983710 1983710 1869946 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KT-2 1047093 963324 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17332333 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862723 2862723 2717886 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2057658 2057658 1937865 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24255770 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594595 1594595 1515563 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983698 1983698 1869934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2000205 2000205 1885103 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983764 1983764 1870000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983710 1983710 1869946 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453416 1453416 1377449 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453426 1453426 1377459 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2057658 2057658 1937865 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24255770 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895118 1895118 1783810 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 KT-2 1047093 963324 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17332333 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302290 1302290 1213341 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1738890 1738890 1644721 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879231 1879231 1769786 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51800685 COSM1235323 132601109 c.2257C>G p.L753V Substitution - Missense 38 7:55181401-55181401 + - PATHOGENIC .96187 Variant of unknown origin 23468066 fine needle aspirate NS 73 ENSP00000395243.3:p.Leu753Val ENST00000454757.6:c.2257C>G 7:g.55181401C>G EGFR ENST00000275493.6 3633 3236 1891284 1891284 1780653 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1459503 1459503 1383446 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1648540 1648540 1563495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 99376120 c.2543C>T p.P848L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000275493.2:p.Pro848Leu ENST00000275493.6:c.2543C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 1648540 1648540 1563495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1965863 1965863 1852356 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142103 2142103 2011321 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1673285 1673285 1586339 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22225786 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631947 1631947 1548817 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895069 1895069 1783761 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302290 1302290 1213341 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2840306 2840306 2695866 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 RERF-LC-A1 946074 862600 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897809 897809 815431 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2440994 2440994 2303834 lung left_upper_lobe NS NS carcinoma adenocarcinoma transformed_to_small_cell_carcinoma NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26557922 NS NS 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965879 1965879 1852372 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1047007 1047007 963238 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1479101 1479101 1402794 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1059473 1059473 975543 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17429313 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1054394 1054394 970465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005461 1005461 922673 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51779191 COSM20897 133272777 c.1948A>G p.S650G Substitution - Missense 38 7:55173942-55173942 + - PATHOGENIC .98113 Variant of unknown origin 16822827 fixed - NOS NS 56 ENSP00000415559.1:p.Ser650Gly ENST00000455089.5:c.1948A>G 7:g.55173942A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1054399 1054399 970470 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239170 2239170 2106702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 59 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239170 2239170 2106702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 59 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899356 899356 816968 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51866714 COSM12372 132616234 c.2009T>G p.I670S Substitution - Missense 38 7:55174003-55174003 + - PATHOGENIC .88145 Variant of unknown origin 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Ile670Ser ENST00000454757.6:c.2009T>G 7:g.55174003T>G EGFR ENST00000275493.6 3633 3236 1974003 1974003 1860245 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1895142 1895142 1783834 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862075 2862075 2717281 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 32122695 circulating tumour NS 62 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2862075 2862075 2717281 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 32122695 circulating tumour NS 62 ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 2675409 2675409 2534683 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345363 2345363 2210035 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493328 1493328 1416318 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230484 1230484 1142298 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM30754 178378833 c.? p.L747P Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu747Pro EGFR ENST00000275493.6 3633 3236 1895085 1895085 1783777 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895158 1895158 1783850 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2148641 2148641 2017771 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1777316 1777316 1681319 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 336 2605108 2465999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 25376516 surgery - NOS NS 59 ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 2680718 2680718 2539991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27998968 surgery-fixed NS 37 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1591027 1591027 1512143 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2437324 2437324 2300174 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23211219 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1661375 1661375 1574990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51788551 COSM214349 132563820 c.1936C>T p.P646S Substitution - Missense 38 7:55173930-55173930 + - PATHOGENIC .98279 Variant of unknown origin 22483783 surgery-fixed NS 82 ENSP00000395243.3:p.Pro646Ser ENST00000454757.6:c.1936C>T 7:g.55173930C>T EGFR ENST00000275493.6 3633 3236 1333761 1333761 1244219 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20395213 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106543 2106543 1984406 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656100 1656100 1570757 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21311943 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1752335 1752335 1657146 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 22912354 fixed - NOS NS EGFR ENST00000275493.6 3633 3236 2345013 2345013 2209685 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 1042860 1042860 959201 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042860 1042860 959201 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1766864 1766864 1671184 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51836814 COSM329081 133242225 c.2066A>G p.E689G Substitution - Missense hom 38 7:55174738-55174738 + - PATHOGENIC .9986 Variant of unknown origin 22422135 surgery - NOS NS ENSP00000415559.1:p.Glu689Gly ENST00000455089.5:c.2066A>G 7:g.55174738A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1530710 1530710 1453082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 21227397 surgery-fixed NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1450926 1450926 1375069 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 51 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2214573 2214573 2082697 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2264311 2264311 2131295 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51803429 COSM7002279 99384811 c.1280G>A p.R427H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000275493.2:p.Arg427His ENST00000275493.6:c.1280G>A 7:g.55157735G>A EGFR ENST00000275493.6 3633 3236 2095946 2095946 1974010 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425723 2425723 2288644 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2788201 2788201 2645582 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 30922578 pleural effusion recurrent 55 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136885 1136885 1049449 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51833668 COSM12675 133253212 c.2440G>A p.A814T Substitution - Missense 38 7:55191824-55191824 + - PATHOGENIC .98898 Variant of unknown origin 17580276 surgery-fixed primary ENSP00000415559.1:p.Ala814Thr ENST00000455089.5:c.2440G>A 7:g.55191824G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-18-T40375 2905680 2759936 NS NS NS NS malignant_melanoma NS NS NS n COSV105864576 COSM9994315 133269189 c.1400C>T p.P467L Substitution - Missense 38 7:55161535-55161535 + - NEUTRAL .20165 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Pro467Leu ENST00000455089.5:c.1400C>T 7:g.55161535C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-05-5425-01 1780080 1684079 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51798380 COSM6178051 132602188 c.2433T>G p.F811L Substitution - Missense 38 7:55191817-55191817 + - NEUTRAL .41266 Variant of unknown origin 417 fresh/frozen - NOS primary 68 ENSP00000395243.3:p.Phe811Leu ENST00000454757.6:c.2433T>G 7:g.55191817T>G EGFR ENST00000275493.6 3633 3236 1895154 1895154 1783846 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1881884 1881884 1772035 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 946821 946821 863344 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345381 2345381 2210053 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476905 2476905 2339674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 2476905 2476905 2339674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2862712 2862712 2717875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 2862712 2862712 2717875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1047870 1047870 964099 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17228019 surgery - NOS NS 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493358 1493358 1416348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237679 1237679 1149426 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1235144 1235144 1146930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 76 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2226856 2226856 2094591 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2840306 2840306 2695866 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1054394 1054394 970465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1576794 1576794 1498235 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 86 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2644798 2644798 2505085 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 28625641 surgery - NOS recurrent 69 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1135427 1135427 1047991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983716 1983716 1869952 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469800 1469800 1393539 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2345504 2345504 2210176 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081819 2081819 1960241 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481317 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2230121 2230121 2097831 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 99377339 c.2239_2240delinsCC p.L747P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 24811487 surgery - NOS NS ENSP00000275493.2:p.Leu747Pro ENST00000275493.6:c.2239_2240delinsCC 7:g.55174776_55174777delinsCC EGFR ENST00000275493.6 3633 3236 1076405 1076405 991659 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17607119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-12-0616-01 1910246 1798537 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 36 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 1895111 1895111 1783803 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1547788 1547788 1469910 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 88 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1141326 1141326 1053774 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083093 2083093 1961514 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24300726 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459522 1459522 1383465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1694965 1694965 1603185 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 47 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2525704 2525704 2387892 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1141305 1141305 1053753 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1695721 1695721 1603933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22673630 fine needle aspirate NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1522886 1522886 1445258 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014311 1014311 931485 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2625548 2625548 2485960 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 3584 915990 833389 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51863898 COSM13196 132621923 c.2423T>C p.I808T Substitution - Missense 38 7:55191807-55191807 + - PATHOGENIC .97798 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000395243.3:p.Ile808Thr ENST00000454757.6:c.2423T>C 7:g.55191807T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592886 1592886 1513812 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51800543 COSM133184 132555896 c.2015T>C p.V672A Substitution - Missense 38 7:55174009-55174009 + - PATHOGENIC .95988 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000395243.3:p.Val672Ala ENST00000454757.6:c.2015T>C 7:g.55174009T>C EGFR ENST00000275493.6 3633 3236 2096180 2096180 1974244 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1896937 1896937 1785624 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 23542356 surgery-fixed recurrent 72 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1174323 1174323 1086342 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118448 2118448 1992683 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1881381 1881381 1771532 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2026151 2026151 1908240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772347 COSM17570 133206975 c.2087C>T p.P696L Substitution - Missense het 38 7:55174759-55174759 + - PATHOGENIC .9905 Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000415559.1:p.Pro696Leu ENST00000455089.5:c.2087C>T 7:g.55174759C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166428 1166428 1078742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773222 COSM28608 132578158 c.2258T>A p.L753H Substitution - Missense het 38 7:55181402-55181402 + - PATHOGENIC .95568 Variant of unknown origin 16870303 surgery - NOS NS 67 ENSP00000395243.3:p.Leu753His ENST00000454757.6:c.2258T>A 7:g.55181402T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226861 2226861 2094596 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51784727 COSM53227 132579418 c.2371C>A p.R791S Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .95567 Variant of unknown origin 24891042 NS NS ENSP00000395243.3:p.Arg791Ser ENST00000454757.6:c.2371C>A 7:g.55191755C>A EGFR ENST00000275493.6 3633 3236 2203101 2203101 2071359 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770748 1770748 1674988 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2595744 2595744 2456620 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS 47 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1729980 1729980 1635951 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1599062 1599062 1519549 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22091430 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1031894 1031894 948685 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 17085664 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1777260 1777260 1681263 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525740 2525740 2387928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1179111 1179111 1091073 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19185949 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 6 2806405 2663124 penis NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV99292322 COSM6503291 132605176 c.2482G>A p.G828R Substitution - Missense 38 7:55191866-55191866 + - PATHOGENIC .98912 Variant of unknown origin 30446465 surgery-fixed metastasis 72 ENSP00000395243.3:p.Gly828Arg ENST00000454757.6:c.2482G>A 7:g.55191866G>A EGFR ENST00000275493.6 3633 3236 1875802 1875802 1766385 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2616328 2616328 2476814 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26118982 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2529054 2529054 2390910 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 27304188 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1795777 1795777 1697525 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23110940 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444792 1444792 1369035 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 UCHRNP3 2682251 2541524 large_intestine NS NS NS other ulcerative_colitis NS NS n COSV51799562 COSM6854575 132572269 c.2906A>G p.D969G Substitution - Missense 38 7:55201282-55201282 + - PATHOGENIC .9951 Variant of unknown origin 28524162 surgery fresh/frozen NS 31 ENSP00000395243.3:p.Asp969Gly ENST00000454757.6:c.2906A>G 7:g.55201282A>G EGFR ENST00000275493.6 3633 3236 2009156 2009156 1891890 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2105800 2105800 1983838 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2250135 2250135 2117394 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24990411 surgery-fixed NS 69 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1989972 1989972 1875311 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51765668 COSM13198 132553967 c.2461G>A p.E821K Substitution - Missense het 38 7:55191845-55191845 + - PATHOGENIC .98912 Variant of unknown origin 23585556 surgery-fixed recurrent ENSP00000395243.3:p.Glu821Lys ENST00000454757.6:c.2461G>A 7:g.55191845G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1974004 1974004 1860246 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51800018 COSM1651735 132583597 c.2420A>G p.K807R Substitution - Missense 38 7:55191804-55191804 + - PATHOGENIC .97982 Variant of unknown origin 23584298 surgery - NOS NS ENSP00000395243.3:p.Lys807Arg ENST00000454757.6:c.2420A>G 7:g.55191804A>G EGFR ENST00000275493.6 3633 3236 1618752 1618752 1537504 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22215752 surgery-fixed NS 51 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618752 1618752 1537504 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891309 1891309 1780678 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1860425 1860425 1751366 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2555789 2555789 2417226 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 26599269 surgery - NOS NS 65 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2555789 2555789 2417226 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 26599269 surgery - NOS NS 65 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1098855 1098855 1013447 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264206 2264206 2131190 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1706967 1706967 1614873 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22722787 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105816 2105816 1983854 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770664 1770664 1674904 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770726 1770726 1674966 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860415 1860415 1751356 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659799 2659799 2519957 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2011147 2011147 1893785 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1684821 178387551 c.? p.E868G Substitution - Missense + - Variant of unknown origin 24002608 surgery - NOS NS ENSP00000275493.2:p.Glu868Gly EGFR_ENST00000454757 ENST00000454757.6 3498 3236 4988 915987 833386 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51866608 COSM13193 132601479 c.2342A>G p.N781S Substitution - Missense 38 7:55191726-55191726 + - PATHOGENIC .9015 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000395243.3:p.Asn781Ser ENST00000454757.6:c.2342A>G 7:g.55191726A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166428 1166428 1078742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773249 COSM28610 132578167 c.2306T>C p.L769P Substitution - Missense het 38 7:55181450-55181450 + - PATHOGENIC .94523 Variant of unknown origin 16870303 surgery - NOS NS 67 ENSP00000395243.3:p.Leu769Pro ENST00000454757.6:c.2306T>C 7:g.55181450T>C EGFR ENST00000275493.6 3633 3236 2482737 2482737 2345464 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26893581 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345014 2345014 2209686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR ENST00000275493.6 3633 3236 2344977 2344977 2209649 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983694 1983694 1869930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631953 1631953 1548823 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2026149 2026149 1908238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2032050 2032050 1913521 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23629442 surgery-fixed NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027818 2027818 1909721 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1875143 1875143 1765734 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSM26142 178386157 c.? p.G857E Substitution - Missense + - Reported in another cancer sample as somatic 23139256 fixed - NOS NS ENSP00000275493.2:p.Gly857Glu EGFR ENST00000275493.6 3633 3236 1319152 1319152 1230051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20146086 cerebrospinal fluid metastasis 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2425570 2425570 2288491 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924333 924333 841108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1456557 1456557 1380532 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042917 1042917 959258 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469344 1469344 1393083 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2659759 2659759 2519917 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2659759 2659759 2519917 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1136866 1136866 1049430 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1429325 1429325 1338776 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2878781 2878781 2733296 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22006985 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891191 1891191 1780560 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891315 1891315 1780684 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51779524 COSM18425 133207486 c.2021G>A p.G674D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Gly674Asp ENST00000455089.5:c.2021G>A 7:g.55174015G>A EGFR ENST00000275493.6 3633 3236 1960177 1960177 1846817 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469863 1469863 1393602 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469863 1469863 1393602 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026220 2026220 1908309 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891327 1891327 1780696 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1067078 1067078 983058 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777291 1777291 1681294 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083807 1083807 998972 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1585359 1585359 1506680 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22011666 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1542178 1542178 1464481 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1355109 1355109 1265204 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2906660 2906660 2760911 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29616327 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1089140 1089140 1004094 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990897 1990897 1876232 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1994212 1994212 1879467 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 99376120 c.2543C>T p.P848L Substitution - Missense het 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 23897956 surgery - NOS primary 56 ENSP00000275493.2:p.Pro848Leu ENST00000275493.6:c.2543C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 522 1716349 1623911 lung left_lower_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22733594 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2770731 2770731 2628932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM30754 178378833 c.? p.L747P Substitution - Missense + - Reported in another cancer sample as somatic 25403583 surgery-fixed metastasis 43 ENSP00000275493.2:p.Leu747Pro EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-16-X27754 2905540 2759796 gastrointestinal_tract_(site_indeterminate) NS NS NS carcinoma NS NS NS n COSV51789261 COSM12986 133218176 c.2294G>A p.G765D Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98244 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000415559.1:p.Gly765Asp ENST00000455089.5:c.2294G>A 7:g.55181438G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2696526 2696526 2555430 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 28201779 surgery fresh/frozen NS 72 ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S001097 1027690 944666 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 133205223 c.731C>A p.A244D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Ala244Asp ENST00000455089.5:c.731C>A 7:g.55154129C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891252 1891252 1780621 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LU0858 1775134 1679358 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22948846 xenograft NS 35 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777323 1777323 1681326 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986166 1986166 1872402 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535036 1535036 1457371 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879232 1879232 1769787 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51767379 COSM85894 99384993 c.2527G>A p.V843I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 23468066 surgery-fixed NS 74 ENSP00000275493.2:p.Val843Ile ENST00000275493.6:c.2527G>A 7:g.55191776G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914811 914811 832260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-86-8055-01 1914088 1802370 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 79 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1625794 1625794 1543018 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1517397 1517397 1439781 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21610522 cerebrospinal fluid metastasis 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 H3255 2776279 2634415 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29681454 NS NS 47 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NCI-H3255 914952 832399 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15492241 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891253 1891253 1780622 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2422830 2422830 2285752 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618764 1618764 1537516 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 KTSq-1 946070 862596 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1835519 1835519 1730551 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23242440 NS NS 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1089605 1089605 1004552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096028 2096028 1974092 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027350 2027350 1909418 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 30 ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1676418 1676418 1589186 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453494 1453494 1377527 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 BL-17-W08054 2905635 2759891 urinary_tract NS NS NS carcinoma transitional_cell_carcinoma NS NS n COSV105863907 COSM9995468 99396822 c.1724G>A p.G575E Substitution - Missense 38 7:55165281-55165281 + - PATHOGENIC .99217 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000275493.2:p.Gly575Glu ENST00000275493.6:c.1724G>A 7:g.55165281G>A EGFR ENST00000275493.6 3633 3236 2000208 2000208 1885106 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542358 1542358 1464661 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1053140 1053140 969211 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17409961 surgery - NOS NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914935 1914935 1802937 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2841966 2841966 2697515 soft_tissue fibrous_tissue_and_uncertain_origin abdomen NS desmoid_tumour-fibromatosis NS NS NS n COSV51773049 COSM22943 99376120 c.2543C>T p.P848L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 32099073 surgery-fixed NS 52 ENSP00000275493.2:p.Pro848Leu ENST00000275493.6:c.2543C>T 7:g.55191792C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2113076 2113076 1987337 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 24595526 surgery-fixed NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1856652 1856652 1749204 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23334261 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230469 1230469 1142283 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468876 1468876 1392615 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21128242 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983708 1983708 1869944 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2637698 2637698 2498071 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 circulating tumour recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2552456 2552456 2413897 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27553514 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 MG-246-tumor 2819109 2675408 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1881374 1881374 1771525 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1844348 1844348 1737382 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1024774 1024774 941751 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17020982 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264189 2264189 2131173 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1188169 1188169 1100068 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51785879 COSM29274 133237805 c.2119T>C p.S707P Substitution - Missense het 38 7:55174791-55174791 + - PATHOGENIC .99066 Variant of unknown origin 19253367 surgery-fixed primary 66 ENSP00000415559.1:p.Ser707Pro ENST00000455089.5:c.2119T>C 7:g.55174791T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226876 2226876 2094611 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064708 2064708 1944785 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1074943 1074943 990197 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924526 924526 841299 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1188169 1188169 1100068 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51785879 COSM29274 99410913 c.2254T>C p.S752P Substitution - Missense het 38 7:55174791-55174791 + - PATHOGENIC .99066 Variant of unknown origin 19253367 surgery-fixed primary 66 ENSP00000275493.2:p.Ser752Pro ENST00000275493.6:c.2254T>C 7:g.55174791T>C EGFR ENST00000275493.6 3633 3236 MYL-027 2672972 2532463 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS n COSM6848491 178383263 c.? p.E551K Substitution - Missense + - Variant of unknown origin 28492226 circulating tumour recurrent 54 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875361 1875361 1765944 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895129 1895129 1783821 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1310472 1310472 1221417 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592878 1592878 1513804 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51811057 COSM133182 132567828 c.1963A>G p.N655D Substitution - Missense 38 7:55173957-55173957 + - PATHOGENIC .98114 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000395243.3:p.Asn655Asp ENST00000454757.6:c.1963A>G 7:g.55173957A>G EGFR ENST00000275493.6 3633 3236 1965207 1965207 1851702 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23803047 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2777954 2777954 2636088 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25982275 surgery - NOS primary 34 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2777954 2777954 2636088 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25982275 surgery - NOS primary 34 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1479085 1479085 1402778 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429263 1429263 1338714 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899339 899339 816951 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1894922 1894922 1783614 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-95-7947-01 1914103 1802385 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51819914 COSM6178048 132556931 c.3020G>T p.R1007I Substitution - Missense 38 7:55201775-55201775 + - PATHOGENIC .971 Variant of unknown origin 417 fresh/frozen - NOS primary 67 ENSP00000395243.3:p.Arg1007Ile ENST00000454757.6:c.3020G>T 7:g.55201775G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 907090 907090 824602 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51833668 COSM12675 132590886 c.2440G>A p.A814T Substitution - Missense het 38 7:55191824-55191824 + - PATHOGENIC .98898 Variant of unknown origin 15710947 surgery-fixed NS ENSP00000395243.3:p.Ala814Thr ENST00000454757.6:c.2440G>A 7:g.55191824G>A EGFR ENST00000275493.6 3633 3236 1855999 1855999 1748552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1169617 178383170 c.? p.L718V Substitution - Missense + - Variant of unknown origin 23337026 fixed - NOS primary ENSP00000275493.2:p.Leu718Val EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879498 1879498 1770000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592881 1592881 1513807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077327 1077327 992581 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429293 1429293 1338744 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 H2172 2776265 2634401 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51778282 COSM3266665 132569270 c.3253A>G p.S1085G Substitution - Missense 38 7:55205372-55205372 + - PATHOGENIC .9316 Variant of unknown origin 29681454 NS NS ENSP00000395243.3:p.Ser1085Gly ENST00000454757.6:c.3253A>G 7:g.55205372A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899320 899320 816932 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 MG-073-tumor 2819009 2675308 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592881 1592881 1513807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767280 COSM133183 133220067 c.2007G>C p.K669N Substitution - Missense 38 7:55174001-55174001 + - PATHOGENIC .89357 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Lys669Asn ENST00000455089.5:c.2007G>C 7:g.55174001G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1530703 1530703 1453075 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21227397 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675155 2675155 2534429 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766300 COSM6849765 132550681 c.2102A>G p.E701G Substitution - Missense 38 7:55174774-55174774 + - PATHOGENIC .97324 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000395243.3:p.Glu701Gly ENST00000454757.6:c.2102A>G 7:g.55174774A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593030 1593030 1513956 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51776171 COSM28605 132591561 c.2476G>A p.A826T Substitution - Missense 38 7:55191860-55191860 + - PATHOGENIC .9853 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000395243.3:p.Ala826Thr ENST00000454757.6:c.2476G>A 7:g.55191860G>A EGFR ENST00000275493.6 3633 3236 1094117 1094117 1008818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18087280 NS NS 49 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676428 1676428 1589196 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 899316 899316 816928 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1649509 1649509 1564296 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22329199 surgery - NOS NS 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2625553 2625553 2485965 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2625553 2625553 2485965 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1994267 1994267 1879522 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23886169 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1770638 1770638 1674878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 899319 899319 816931 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891169 1891169 1780538 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 11-18-ER2-1 1731374 1637340 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22815900 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1664596 1664596 1578046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21899495 pleural effusion NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025389 2025389 1907478 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422938 2422938 2285860 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965920 1965920 1852413 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1334749 1334749 1245134 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20401612 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1732972 1732972 1638921 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22833420 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096224 2096224 1974288 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1879557 1879557 1770059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1469416 1469416 1393155 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-089-tumor 2819020 2675319 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1551477 1551477 1473582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1602807 1602807 1522143 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1320681 1320681 1231568 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20155428 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777406 1777406 1681409 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983099 983099 898817 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2153079 2153079 2022089 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2471440 2471440 2334227 skin NS NS NS malignant_melanoma NS NS NS n COSV51836136 COSM5574310 133222649 c.2764G>A p.E922K Substitution - Missense 38 7:55200366-55200366 + - PATHOGENIC .99379 Reported in another cancer sample as somatic 25452114 surgery fresh/frozen metastasis 55 ENSP00000415559.1:p.Glu922Lys ENST00000455089.5:c.2764G>A 7:g.55200366G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924291 924291 841066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043852 1043852 960193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2141648 2141648 2010866 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24657128 surgery fresh/frozen NS 73 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1648526 1648526 1563481 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830809 COSM85993 133240844 c.2125A>G p.K709E Substitution - Missense 38 7:55174797-55174797 + - PATHOGENIC .99211 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000415559.1:p.Lys709Glu ENST00000455089.5:c.2125A>G 7:g.55174797A>G EGFR ENST00000275493.6 3633 3236 1983753 1983753 1869989 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2095978 2095978 1974042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515250 1515250 1437860 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469794 1469794 1393533 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1278183 1278183 1189481 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637092 1637092 1553140 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096131 2096131 1974195 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770734 1770734 1674974 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110449 1110449 1024327 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879565 1879565 1770067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2345123 2345123 2209795 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1498640 1498640 1421518 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21315472 surgery - NOS metastasis 65 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1668460 1668460 1581753 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 983166 983166 898884 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1196954 1196954 1108849 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 BL-16-R00716 2905308 2759564 gastrointestinal_tract_(site_indeterminate) NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2422912 2422912 2285834 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2426844 2426844 2289765 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2426844 2426844 2289765 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042921 1042921 959262 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1618794 1618794 1537546 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 71 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618794 1618794 1537546 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 26 1596836 1517549 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20093389 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029018 2029018 1910900 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921887 1921887 1809205 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515243 1515243 1437853 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618706 1618706 1537458 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 49 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1623719 1623719 1541306 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21615826 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1585335 1585335 1506656 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22011666 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1770583 1770583 1674823 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083066 1083066 998231 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17685931 surgery-fixed NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095904 2095904 1973968 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2432446 2432446 2295347 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25798276 NS NS 81 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2141460 2141460 2010678 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24636848 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1874736 1874736 1765327 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1855998 1855998 1748551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS primary ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1855998 1855998 1748551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2422785 2422785 2285707 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336830 1336830 1247215 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637693 2637693 2498066 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237683 1237683 1149430 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777413 1777413 1681416 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664326 2664326 2524406 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 32 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264255 2264255 2131239 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 587256 1766760 1671080 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51771628 COSM1205054 99379331 c.2011C>T p.R671C Substitution - Missense 38 7:55173074-55173074 + - PATHOGENIC .99716 Reported in another cancer sample as somatic 22895193 surgery fresh/frozen primary ENSP00000275493.2:p.Arg671Cys ENST00000275493.6:c.2011C>T 7:g.55173074C>T EGFR ENST00000275493.6 3633 3236 1891318 1891318 1780687 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 99378223 c.2327G>A p.R776H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Arg776His ENST00000275493.6:c.2327G>A 7:g.55181336G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1000053 1000053 917276 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897825 897825 815447 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EGCT1088 2490716 2353365 testis NS NS NS germ_cell_tumour choriocarcinoma NS NS n COSV51835294 COSM5749118 133243207 c.1588G>A p.G530R Substitution - Missense 38 7:55165280-55165280 + - PATHOGENIC .99792 Variant of unknown origin 26956871 surgery fresh/frozen primary ENSP00000415559.1:p.Gly530Arg ENST00000455089.5:c.1588G>A 7:g.55165280G>A EGFR ENST00000275493.6 3633 3236 2432460 2432460 2295361 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25798276 NS NS 89 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459527 1459527 1383470 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881904 1881904 1772055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 73 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1881904 1881904 1772055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228749 2228749 2096461 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24956168 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1813215 1813215 1712549 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23079729 surgery - NOS metastasis 42 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1996550 1996550 1881759 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23922984 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1996550 1996550 1881759 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23922984 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226863 2226863 2094598 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1876990 1876990 1767552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1075004 1075004 990258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 71 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1740210 1740210 1645811 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766331 COSM12366 133243522 c.2437C>A p.L813M Substitution - Missense het 38 7:55191821-55191821 + - PATHOGENIC .93782 Reported in another cancer sample as somatic 22836650 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Met ENST00000455089.5:c.2437C>A 7:g.55191821C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1740210 1740210 1645811 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22836650 surgery fresh/frozen NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-17-N27113 2905421 2759677 gastrointestinal_tract_(site_indeterminate) NS NS NS carcinoma NS NS NS n COSV105864561 COSM9997503 132605318 c.3115G>A p.D1039N Substitution - Missense 38 7:55202604-55202604 + - PATHOGENIC .96545 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000395243.3:p.Asp1039Asn ENST00000454757.6:c.3115G>A 7:g.55202604G>A EGFR ENST00000275493.6 3633 3236 2000209 2000209 1885107 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838637 1838637 1732738 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469489 1469489 1393228 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842985 1842985 1736233 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2864419 2864419 2719575 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26199566 surgery-fixed NS 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474450 2474450 2337219 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163040 2163040 2031624 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587274 1587274 1508445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862784 2862784 2717947 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2862784 2862784 2717947 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2898404 2898404 2752682 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23800712 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246715 1246715 1158394 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 132574485 c.1027G>A p.D343N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000395243.3:p.Asp343Asn ENST00000454757.6:c.1027G>A 7:g.55156787G>A EGFR ENST00000275493.6 3633 3236 2345428 2345428 2210100 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1355121 1355121 1265216 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587198 1587198 1508369 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS 57 ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1576789 1576789 1498230 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 71 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009142 2009142 1891876 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1919304 1919304 1806625 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51803771 COSM14068 99392333 c.2308G>A p.D770N Substitution - Missense 38 7:55181317-55181317 + - PATHOGENIC .97623 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Asp770Asn ENST00000275493.6:c.2308G>A 7:g.55181317G>A EGFR ENST00000275493.6 3633 3236 1882248 1882248 1772399 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23392229 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2096277 2096277 1974341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345081 2345081 2209753 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345445 2345445 2210117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264277 2264277 2131261 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770666 1770666 1674906 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1517578 1517578 1439959 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21573178 surgery-fixed metastasis 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1498648 1498648 1421526 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21315472 surgery - NOS primary 76 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2684448 2684448 2543485 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29128427 circulating tumour recurrent 44 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2684448 2684448 2543485 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29128427 circulating tumour recurrent 44 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587262 1587262 1508433 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346479 2346479 2211142 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2273785 2273785 2140345 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM4389219 178384668 c.? p.G796D Substitution - Missense + - Reported in another cancer sample as somatic 25300933 surgery-fixed NS ENSP00000275493.2:p.Gly796Asp EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2733534 2733534 2592287 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 29704676 surgery - NOS recurrent 36 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2113068 2113068 1987329 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51767182 COSM27110 133210338 c.2221G>A p.V741M Substitution - Missense 38 7:55181365-55181365 + - PATHOGENIC .97319 Reported in another cancer sample as somatic 24595526 surgery-fixed NS ENSP00000415559.1:p.Val741Met ENST00000455089.5:c.2221G>A 7:g.55181365G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2113068 2113068 1987329 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24595526 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2425735 2425735 2288656 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2157002 2157002 2025977 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422934 2422934 2285856 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637223 1637223 1553271 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592881 1592881 1513807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 RERF-LC-A1 946074 862600 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2862713 2862713 2717876 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780877 COSM26717 99375410 c.2579A>T p.K860I Substitution - Missense 38 7:55191828-55191828 + - PATHOGENIC .95726 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Lys860Ile ENST00000275493.6:c.2579A>T 7:g.55191828A>T EGFR ENST00000275493.6 3633 3236 2862713 2862713 2717876 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 907085 907085 824597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345424 2345424 2210096 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095943 2095943 1974007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1795768 1795768 1697516 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23110940 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885190 1885190 1775077 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LIM1215_R5_Cetux 2841371 2696923 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51776247 COSM6110417 133220044 c.1258G>A p.G420R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000415559.1:p.Gly420Arg ENST00000455089.5:c.1258G>A 7:g.55160233G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1506756 1506756 1429625 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 21422421 surgery - NOS metastasis 89 ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1506756 1506756 1429625 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51777782 COSM6227 133210005 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 21422421 surgery - NOS metastasis 89 ENSP00000415559.1:p.His790Leu ENST00000455089.5:c.2369A>T 7:g.55191753A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895075 1895075 1783767 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226911 2226911 2094646 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51789830 COSM26035 132556581 c.2456C>A p.A819E Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .95798 Variant of unknown origin 24891042 NS NS ENSP00000395243.3:p.Ala819Glu ENST00000454757.6:c.2456C>A 7:g.55191840C>A EGFR ENST00000275493.6 3633 3236 1591008 1591008 1512124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027781 2027781 1909684 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 RPMI-8226 1092628 1007450 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS n COSV51773111 COSM13185 99375118 c.2252C>T p.T751I Substitution - Missense het 38 7:55174789-55174789 + - PATHOGENIC .99151 Reported in another cancer sample as somatic 18006781 cell-line NS ENSP00000275493.2:p.Thr751Ile ENST00000275493.6:c.2252C>T 7:g.55174789C>T EGFR ENST00000275493.6 3633 3236 1672472 1672472 1585526 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21729655 surgery-fixed primary 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118449 2118449 1992684 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 899328 899328 816940 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1885188 1885188 1775075 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1610430 1610430 1529670 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22142557 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983692 1983692 1869928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891298 1891298 1780667 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592885 1592885 1513811 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765252 COSM13009 133225791 c.1991A>G p.E664G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Glu664Gly ENST00000455089.5:c.1991A>G 7:g.55173985A>G EGFR ENST00000275493.6 3633 3236 1278189 1278189 1189487 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515233 1515233 1437843 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009160 2009160 1891894 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1876992 1876992 1767554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875801 1875801 1766384 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862863 2862863 2718025 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51852379 COSM22942 132567403 c.2200G>T p.G734C Substitution - Missense 38 7:55181344-55181344 + - PATHOGENIC .98402 Variant of unknown origin 29489023 surgery - NOS NS ENSP00000395243.3:p.Gly734Cys ENST00000454757.6:c.2200G>T 7:g.55181344G>T EGFR ENST00000275493.6 3633 3236 1881931 1881931 1772082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777331 1777331 1681334 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637095 1637095 1553143 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026148 2026148 1908237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2026148 2026148 1908237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 2008784 2008784 1891518 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1602796 1602796 1522132 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 NPC0001PT00329T00329 2857335 2712635 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2651872 2651872 2512012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27257132 surgery - NOS primary 71 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1839252 1839252 1733353 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51828195 COSM13180 132573740 c.2053C>T p.L685F Substitution - Missense 38 7:55174725-55174725 + - PATHOGENIC .96849 Variant of unknown origin 23244191 surgery-fixed primary ENSP00000395243.3:p.Leu685Phe ENST00000454757.6:c.2053C>T 7:g.55174725C>T EGFR ENST00000275493.6 3633 3236 1983728 1983728 1869964 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1077330 1077330 992584 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2425737 2425737 2288658 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345469 2345469 2210141 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2819307 2819307 2675606 lung left_upper_lobe NS NS carcinoma invasive_mucinous_adenocarcinoma NS NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 30572543 circulating tumour NS 80 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593007 1593007 1513933 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1330079 1330079 1240564 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51847775 COSM41663 132570105 c.2327T>C p.I776T Substitution - Missense 38 7:55181471-55181471 + - PATHOGENIC .92352 Variant of unknown origin 20208477 surgery - NOS NS ENSP00000395243.3:p.Ile776Thr ENST00000454757.6:c.2327T>C 7:g.55181471T>C EGFR ENST00000275493.6 3633 3236 2908043 2908043 2762222 lung left_lower_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457237 surgery-fixed NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345452 2345452 2210124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230490 1230490 1142304 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM22420 178383004 c.? p.V843I Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Val843Ile EGFR ENST00000275493.6 3633 3236 1042899 1042899 959240 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471802 1471802 1395540 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51780206 COSM12373 99380273 c.2159C>T p.S720F Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .9768 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000275493.2:p.Ser720Phe ENST00000275493.6:c.2159C>T 7:g.55174018C>T EGFR ENST00000275493.6 3633 3236 1530967 1530967 1453339 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2076197 2076197 1955010 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 24396447 bronchoalveolar lavage fluid NS 78 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1895117 1895117 1783809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891265 1891265 1780634 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1734082 1734082 1640031 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22842370 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1088971 1088971 1003925 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17917328 cerebrospinal fluid metastasis 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1734094 1734094 1640043 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22842370 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-WS009-T3 2869941 2724938 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105111008 COSM9808725 133276286 c.3098C>T p.T1033I Substitution - Missense 38 7:55202587-55202587 + - NEUTRAL .10728 Variant of unknown origin 26950094 surgery - NOS NS ENSP00000415559.1:p.Thr1033Ile ENST00000455089.5:c.3098C>T 7:g.55202587C>T EGFR ENST00000275493.6 3633 3236 SH-437 1493307 1416297 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51773049 COSM22943 99376120 c.2543C>T p.P848L Substitution - Missense het 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 21372829 cell-line primary 49 ENSP00000275493.2:p.Pro848Leu ENST00000275493.6:c.2543C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 1823877 1823877 1722271 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23212424 surgery-fixed primary 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444726 1444726 1368969 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2595767 2595767 2456643 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1166943 178385114 c.? p.V769L Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Val769Leu EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042913 1042913 959254 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891231 1891231 1780600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103802 1103802 1018054 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18271876 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-60-2708-01 1782119 1686118 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51807273 COSM747426 132564941 c.2024C>G p.S675C Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .97998 Variant of unknown origin 418 fresh/frozen - NOS primary 64 ENSP00000395243.3:p.Ser675Cys ENST00000454757.6:c.2024C>G 7:g.55174018C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226912 2226912 2094647 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51790813 COSM4170225 132597201 c.2462A>T p.E821V Substitution - Missense 38 7:55191846-55191846 + - PATHOGENIC .98607 Variant of unknown origin 24891042 NS NS ENSP00000395243.3:p.Glu821Val ENST00000454757.6:c.2462A>T 7:g.55191846A>T EGFR ENST00000275493.6 3633 3236 2595767 2595767 2456643 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1885196 1885196 1775083 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000244 2000244 1885142 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770689 1770689 1674929 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1746658 1746658 1651634 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 79 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469341 1469341 1393080 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1486480 1486480 1410098 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21107288 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345397 2345397 2210069 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067072 1067072 983052 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875349 1875349 1765932 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625599 2625599 2486011 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 44 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 BL-18-M09457 2905536 2759792 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1983781 1983781 1870017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2027786 2027786 1909689 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027786 2027786 1909689 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046046 2046046 1926341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960187 1960187 1846827 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986155 1986155 1872391 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226771 2226771 2094506 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51795632 COSM26509 133221986 c.2092G>A p.A698T Substitution - Missense 38 7:55174764-55174764 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Ala698Thr ENST00000455089.5:c.2092G>A 7:g.55174764G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2637591 2637591 2497964 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51826065 COSM6438146 132578895 c.1956A>T p.E652D Substitution - Missense 38 7:55173950-55173950 + - PATHOGENIC .86906 Variant of unknown origin 27105513 surgery-fixed NS ENSP00000395243.3:p.Glu652Asp ENST00000454757.6:c.1956A>T 7:g.55173950A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239173 2239173 2106705 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 70 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1738936 1738936 1644767 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2509057 2509057 2371392 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51783296 COSM5878511 133252328 c.526G>T p.G176W Substitution - Missense 38 7:55152578-55152578 + - NEUTRAL .4823 Variant of unknown origin 26919320 surgery - NOS NS 43 ENSP00000415559.1:p.Gly176Trp ENST00000455089.5:c.526G>T 7:g.55152578G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1974004 1974004 1860246 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51800006 COSM1651734 132583593 c.2269G>A p.V757I Substitution - Missense 38 7:55181413-55181413 + - PATHOGENIC .8748 Variant of unknown origin 23584298 surgery - NOS NS ENSP00000395243.3:p.Val757Ile ENST00000454757.6:c.2269G>A 7:g.55181413G>A EGFR ENST00000275493.6 3633 3236 1656101 1656101 1570758 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21311943 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2538972 2538972 2400568 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 99377339 c.2239_2240delinsCC p.L747P Substitution - Missense het 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 27499993 surgery-fixed NS 61 ENSP00000275493.2:p.Leu747Pro ENST00000275493.6:c.2239_2240delinsCC 7:g.55174776_55174777delinsCC EGFR ENST00000275493.6 3633 3236 1885167 1885167 1775054 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2644120 2644120 2504407 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966323 1966323 1852816 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542237 1542237 1464540 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21784628 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1637063 1637063 1553111 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246624 1246624 1158303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891330 1891330 1780699 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2148603 2148603 2017733 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1450939 1450939 1375082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 46 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096186 2096186 1974250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237664 1237664 1149411 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2065006 2065006 1945083 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-189-tumor 2819075 2675374 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2644798 2644798 2505085 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 28625641 surgery - NOS recurrent 69 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1054394 1054394 970465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1576794 1576794 1498235 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 86 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1235144 1235144 1146930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 76 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226856 2226856 2094591 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2840306 2840306 2695866 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2226768 2226768 2094503 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1141290 1141290 1053738 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983144 983144 898862 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1467360 1467360 1391206 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 20940188 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1467360 1467360 1391206 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 20940188 surgery - NOS NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1991300 1991300 1876635 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067042 1067042 983022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 G45 1179740 1091702 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51815137 COSM28943 132583867 c.2162T>C p.M721T Substitution - Missense 38 7:55181306-55181306 + - PATHOGENIC .97686 Variant of unknown origin 19096301 surgery fresh/frozen primary 61 ENSP00000395243.3:p.Met721Thr ENST00000454757.6:c.2162T>C 7:g.55181306T>C EGFR ENST00000275493.6 3633 3236 2064720 2064720 1944797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1279054 1279054 1190350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed primary 48 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2817999 2817999 2674298 lung right NS NS carcinoma adenocarcinoma NS NS n COSV104368882 COSM9263867 132587436 c.2224C>A p.Q742K Substitution - Missense 38 7:55181368-55181368 + - PATHOGENIC .97684 Variant of unknown origin 31422893 pleural effusion metastasis 72 ENSP00000395243.3:p.Gln742Lys ENST00000454757.6:c.2224C>A 7:g.55181368C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51841162 COSM1090865 132552652 c.459C>A p.S153R Substitution - Missense het 38 7:55151328-55151328 + - PATHOGENIC .8706 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000395243.3:p.Ser153Arg ENST00000454757.6:c.459C>A 7:g.55151328C>A EGFR ENST00000275493.6 3633 3236 2067304 2067304 1947101 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23783797 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2867759 2867759 2722782 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25345567 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1173387 1173387 1085471 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043867 1043867 960208 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043872 1043872 960213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043872 1043872 960213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 133222251 c.2146G>T p.D716Y Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99554 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Asp716Tyr ENST00000455089.5:c.2146G>T 7:g.55174818G>T EGFR ENST00000275493.6 3633 3236 1770647 1770647 1674887 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 109600 2812903 2669317 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 46 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1083796 1083796 998961 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421215 2421215 2284137 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345393 2345393 2210065 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862120 2862120 2717322 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862120 2862120 2717322 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-14-F34521 2905527 2759783 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51836288 COSM6348843 133235022 c.2207G>T p.C736F Substitution - Missense 38 7:55181351-55181351 + - PATHOGENIC .98402 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000415559.1:p.Cys736Phe ENST00000455089.5:c.2207G>T 7:g.55181351G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 6 2806405 2663124 penis NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV99292321 COSM9115440 132605168 c.2477C>A p.A826E Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98397 Variant of unknown origin 30446465 surgery-fixed metastasis 72 ENSP00000395243.3:p.Ala826Glu ENST00000454757.6:c.2477C>A 7:g.55191861C>A EGFR ENST00000275493.6 3633 3236 2142055 2142055 2011273 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24468202 surgery - NOS NS 56 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2142055 2142055 2011273 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 56 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450848 1450848 1374991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 57 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593003 1593003 1513929 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1816945 1816945 1716113 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879515 1879515 1770017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001553 1001553 918776 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15851406 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899352 899352 816964 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1484342 1484342 1407968 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 133203473 c.2117C>T p.T706I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Reported in another cancer sample as somatic 21266046 surgery-fixed primary 64 ENSP00000415559.1:p.Thr706Ile ENST00000455089.5:c.2117C>T 7:g.55174789C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429264 1429264 1338715 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1310477 1310477 1221422 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1876988 1876988 1767550 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1459518 1459518 1383461 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279089 1279089 1190385 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed metastasis 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2426828 2426828 2289749 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent 33 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1453427 1453427 1377460 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2148607 2148607 2017737 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874740 1874740 1765331 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637140 1637140 1553188 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667642 1667642 1580937 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22534670 surgery-fixed NS 40 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1974003 1974003 1860245 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1974003 1974003 1860245 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895142 1895142 1783834 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862075 2862075 2717281 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 32122695 circulating tumour NS 62 ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-0616-01 1910246 1798537 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 36 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891303 1891303 1780672 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1648540 1648540 1563495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1648540 1648540 1563495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 133204348 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000415559.1:p.Pro803Leu ENST00000455089.5:c.2408C>T 7:g.55191792C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897809 897809 815431 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895085 1895085 1783777 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1047007 1047007 963238 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862075 2862075 2717281 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 32122695 circulating tumour NS 62 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1179044 1179044 1091006 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51805944 COSM28931 132608179 c.2398G>A p.V800M Substitution - Missense hom 38 7:55191782-55191782 + - PATHOGENIC .98912 Variant of unknown origin 19190079 surgery-fixed primary 35 ENSP00000395243.3:p.Val800Met ENST00000454757.6:c.2398G>A 7:g.55191782G>A EGFR ENST00000275493.6 3633 3236 2225974 2225974 2093709 lung NS NS NS carcinoma NS NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24924582 fine needle aspirate NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1875347 1875347 1765930 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2865248 2865248 2720378 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29413048 surgery-fixed primary 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1530966 1530966 1453338 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1302292 1302292 1213343 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2476857 2476857 2339626 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120932 1120932 1034088 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2239180 2239180 2106712 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 64 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2239180 2239180 2106712 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1675622 1675622 1588502 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22560922 surgery-fixed metastasis 56 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2680718 2680718 2539991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27998968 surgery-fixed NS 37 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DM51 2466875 2329706 skin neck NS NS malignant_melanoma desmoplastic NS NS n COSV51774157 COSM5608355 132589619 c.1671A>T p.E557D Substitution - Missense 38 7:55165363-55165363 + - PATHOGENIC .71202 Variant of unknown origin 26343386 surgery-fixed NS 88 ENSP00000395243.3:p.Glu557Asp ENST00000454757.6:c.1671A>T 7:g.55165363A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2290053 2290053 2156118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51804114 COSM4424126 132596111 c.1970C>T p.A657V Substitution - Missense het 38 7:55173964-55173964 + - PATHOGENIC .97446 Variant of unknown origin 16740761 surgery - NOS NS 50 ENSP00000395243.3:p.Ala657Val ENST00000454757.6:c.1970C>T 7:g.55173964C>T EGFR ENST00000275493.6 3633 3236 1103765 1103765 1018017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1493364 1493364 1416354 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450926 1450926 1375069 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 51 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51803429 COSM7002279 133213353 c.1145G>A p.R382H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000415559.1:p.Arg382His ENST00000455089.5:c.1145G>A 7:g.55157735G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895154 1895154 1783846 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 946821 946821 863344 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862712 2862712 2717875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862712 2862712 2717875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891284 1891284 1780653 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471804 1471804 1395542 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51784727 COSM53227 132579418 c.2371C>A p.R791S Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .95567 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000395243.3:p.Arg791Ser ENST00000454757.6:c.2371C>A 7:g.55191755C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2230121 2230121 2097831 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 133205309 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 24811487 surgery - NOS NS ENSP00000415559.1:p.Leu702Pro ENST00000455089.5:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1694965 1694965 1603185 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 47 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1990902 1990902 1876237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2046179 2046179 1926474 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2027861 2027861 1909764 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2009139 2009139 1891873 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602813 1602813 1522149 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1515241 1515241 1437851 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770509 1770509 1674749 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042860 1042860 959201 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042860 1042860 959201 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895111 1895111 1783803 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983697 1983697 1869933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2613983 2613983 2474792 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 28352759 surgery - NOS recurrent 59 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1135427 1135427 1047991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983716 1983716 1869952 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875802 1875802 1766385 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2616328 2616328 2476814 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26118982 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625548 2625548 2485960 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2081912 2081912 1960334 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469413 1469413 1393152 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141316 1141316 1053764 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1523396 1523396 1445768 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 21626329 surgery-fixed recurrent ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2148512 2148512 2017642 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637264 1637264 1553312 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1886217 1886217 1776102 endometrium NS NS NS carcinoma NS NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 23438670 surgery-fixed primary ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 1879508 1879508 1770010 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1965818 1965818 1852311 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2579439 2579439 2440776 NS NS NS NS malignant_melanoma NS NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2579439 2579439 2440776 NS NS NS NS malignant_melanoma NS NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1591069 1591069 1512185 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203111 2203111 2071369 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 897850 897850 815472 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51804843 COSM12429 99380902 c.2573_2574delinsGT p.L858R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573_2574delinsGT 7:g.55191822_55191823delinsGT EGFR ENST00000275493.6 3633 3236 897850 897850 815472 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51771864 COSM6226 99383011 c.2326C>T p.R776C Substitution - Missense 38 7:55181335-55181335 + - PATHOGENIC .97187 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Arg776Cys ENST00000275493.6:c.2326C>T 7:g.55181335C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009156 2009156 1891890 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1098817 1098817 1013409 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 51 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1493344 1493344 1416334 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098855 1098855 1013447 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914815 914815 832264 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 132553412 c.2477C>G p.A826G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 15738541 surgery fresh/frozen recurrent ENSP00000395243.3:p.Ala826Gly ENST00000454757.6:c.2477C>G 7:g.55191861C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162177 1162177 1074509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51818033 COSM28508 132568563 c.1969G>T p.A657S Substitution - Missense 38 7:55173963-55173963 + - PATHOGENIC .97325 Variant of unknown origin 19020901 NS NS ENSP00000395243.3:p.Ala657Ser ENST00000454757.6:c.1969G>T 7:g.55173963G>T EGFR ENST00000275493.6 3633 3236 2862078 2862078 2717283 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 32122695 circulating tumour metastasis 62 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 MG-150-tumor 2819055 2675354 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2555789 2555789 2417226 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 26599269 surgery - NOS NS 65 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136866 1136866 1049430 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345066 2345066 2209738 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2552470 2552470 2413911 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27553514 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2498858 2498858 2361209 lung left_upper_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27133750 surgery - NOS metastasis 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891244 1891244 1780613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1097654 1097654 1012315 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1136887 1136887 1049451 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1444760 1444760 1369003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429325 1429325 1338776 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1637147 1637147 1553195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226888 2226888 2094623 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345358 2345358 2210030 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2652492 2652492 2512619 breast NS NS NS carcinoma HER-positive_carcinoma NS NS n COSM1166943 178385114 c.? p.V769L Substitution - Missense + - Reported in another cancer sample as somatic 28750640 surgery-fixed NS ENSP00000275493.2:p.Val769Leu EGFR ENST00000275493.6 3633 3236 1475408 1475408 1399107 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008785 2008785 1891519 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667701 1667701 1580994 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2509042 2509042 2371377 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 133206822 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 74 ENSP00000415559.1:p.Thr218Pro ENST00000455089.5:c.652A>C 7:g.55154050A>C EGFR ENST00000275493.6 3633 3236 587376 1766805 1671125 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51771628 COSM1205054 99379331 c.2011C>T p.R671C Substitution - Missense 38 7:55173074-55173074 + - PATHOGENIC .99716 Reported in another cancer sample as somatic 22895193 surgery fresh/frozen primary ENSP00000275493.2:p.Arg671Cys ENST00000275493.6:c.2011C>T 7:g.55173074C>T EGFR ENST00000275493.6 3633 3236 1891165 1891165 1780534 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2625561 2625561 2485973 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 51 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-W08054 2905635 2759891 urinary_tract NS NS NS carcinoma transitional_cell_carcinoma NS NS n COSV105863907 COSM9995468 133222796 c.1589G>A p.G530E Substitution - Missense 38 7:55165281-55165281 + - PATHOGENIC .99217 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000415559.1:p.Gly530Glu ENST00000455089.5:c.1589G>A 7:g.55165281G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1319152 1319152 1230051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20146086 cerebrospinal fluid metastasis 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1637169 1637169 1553217 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879555 1879555 1770057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042917 1042917 959258 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659759 2659759 2519917 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659759 2659759 2519917 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891309 1891309 1780678 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860425 1860425 1751366 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2161694 2161694 2030301 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24813888 surgery fresh/frozen recurrent 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2161694 2161694 2030301 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 24813888 surgery fresh/frozen recurrent 58 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2425761 2425761 2288682 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1328029 1328029 1238518 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20307913 surgery - NOS metastasis 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026263 2026263 1908352 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1103627 1103627 1017879 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 59 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2095998 2095998 1974062 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345053 2345053 2209725 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089140 1089140 1004094 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1994212 1994212 1879467 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 133204348 c.2408C>T p.P803L Substitution - Missense het 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 23897956 surgery - NOS primary 56 ENSP00000415559.1:p.Pro803Leu ENST00000455089.5:c.2408C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 1237699 1237699 1149446 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874748 1874748 1765339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444717 1444717 1368960 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842977 1842977 1736225 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891253 1891253 1780622 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891327 1891327 1780696 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067078 1067078 983058 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2095999 2095999 1974063 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000059 2000059 1884957 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS 54 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2136676 2136676 2006227 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402750 2402750 2265603 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 26267891 surgery-fixed primary 72 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1445186 1445186 1369429 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 20682976 surgery - NOS metastasis 57 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422825 2422825 2285747 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1209870 1209870 1121747 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 19155283 autopsy - NOS recurrent 58 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618790 1618790 1537542 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 66 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525706 2525706 2387894 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746675 1746675 1651651 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 36 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469819 1469819 1393558 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2476874 2476874 2339643 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1909765 1909765 1798282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23559152 surgery-fixed NS 48 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1113046 1113046 1026547 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 18458038 surgery - NOS NS 88 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481262 1481262 1404891 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481235 1481235 1404864 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096277 2096277 1974341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1705527 1705527 1613433 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618773 1618773 1537525 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22215752 surgery-fixed NS 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469820 1469820 1393559 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879232 1879232 1769787 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51767379 COSM85894 133213549 c.2392G>A p.V798I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 23468066 surgery-fixed NS 74 ENSP00000415559.1:p.Val798Ile ENST00000455089.5:c.2392G>A 7:g.55191776G>A EGFR ENST00000275493.6 3633 3236 1770708 1770708 1674948 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515254 1515254 1437864 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1514594 1514594 1437204 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21558399 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 H3255 2776279 2634415 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29681454 NS NS 47 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1514601 1514601 1437211 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21558399 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986147 1986147 1872383 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089605 1089605 1004552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2027350 2027350 1909418 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 30 ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2841966 2841966 2697515 soft_tissue fibrous_tissue_and_uncertain_origin abdomen NS desmoid_tumour-fibromatosis NS NS NS n COSV51773049 COSM22943 133204348 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 32099073 surgery-fixed NS 52 ENSP00000415559.1:p.Pro803Leu ENST00000455089.5:c.2408C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 2239168 2239168 2106700 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 99378223 c.2327G>A p.R776H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 39 ENSP00000275493.2:p.Arg776His ENST00000275493.6:c.2327G>A 7:g.55181336G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-246-tumor 2819109 2675408 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2626141 2626141 2486553 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51817684 COSM6191493 133259763 c.2441C>T p.A814V Substitution - Missense 38 7:55191825-55191825 + - PATHOGENIC .97885 Variant of unknown origin 26645239 surgery-fixed NS ENSP00000415559.1:p.Ala814Val ENST00000455089.5:c.2441C>T 7:g.55191825C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51841225 COSM1090895 132552691 c.3364C>A p.L1122M Substitution - Missense het 38 7:55205483-55205483 + - PATHOGENIC .76649 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000395243.3:p.Leu1122Met ENST00000454757.6:c.3364C>A 7:g.55205483C>A EGFR ENST00000275493.6 3633 3236 1284747 1284747 1196042 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 16467085 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2000270 2000270 1885168 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1036708 1036708 953465 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 17106442 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345532 2345532 2210204 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 897846 897846 815468 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1475384 1475384 1399083 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734183 1734183 1640132 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22843912 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459769 1459769 1383712 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 21062932 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1479920 1479920 1403580 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773712 COSM13433 99385694 c.2318A>G p.H773R Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98391 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.His773Arg ENST00000275493.6:c.2318A>G 7:g.55181327A>G EGFR ENST00000275493.6 3633 3236 1059480 1059480 975550 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 17429313 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1777371 1777371 1681374 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345442 2345442 2210114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KTSq-1 946070 862596 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1823863 1823863 1722257 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23212424 surgery-fixed primary 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2675372 2675372 2534646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 99376120 c.2543C>T p.P848L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Pro848Leu ENST00000275493.6:c.2543C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 1453491 1453491 1377524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2878804 2878804 2733319 lung NS NS NS carcinoma undifferentiated_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22006985 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965901 1965901 1852394 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1338230 1338230 1248615 lung right_upper_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 20357619 surgery - NOS primary 67 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2096277 2096277 1974341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2238935 2238935 2106467 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25137181 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1445186 1445186 1369429 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20682976 surgery - NOS metastasis 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264135 2264135 2131119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029010 2029010 1910892 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095948 2095948 1974012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838548 1838548 1732649 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881920 1881920 1772071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264336 2264336 2131320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-073-tumor 2819009 2675308 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1246667 1246667 1158346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638734 1638734 1554733 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676434 1676434 1589202 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618790 1618790 1537542 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106531 2106531 1984394 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638754 1638754 1554753 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960160 1960160 1846800 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264221 2264221 2131205 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1113042 1113042 1026543 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18458038 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 NPC0001PT00300T00300 2857355 2712655 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1881374 1881374 1771525 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264298 2264298 2131282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2245045 2245045 2112321 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1672484 1672484 1585538 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21729655 surgery-fixed primary 46 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2465697 2465697 2328528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26724810 surgery - NOS primary 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1635376 1635376 1551881 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22335887 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096049 2096049 1974113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1338230 1338230 1248615 lung right_upper_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20357619 surgery - NOS primary 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422921 2422921 2285843 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887412 1887412 1777084 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346528 2346528 2211191 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734167 1734167 1640116 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22843912 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770533 1770533 1674773 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345453 2345453 2210125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777240 1777240 1681243 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2644124 2644124 2504411 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264195 2264195 2131179 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549124 2549124 2410579 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476874 2476874 2339643 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838707 1838707 1732808 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878788 2878788 2733303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22006985 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205963 2205963 2074196 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914934 1914934 1802936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2406830 2406830 2269710 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 47 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105804 2105804 1983842 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1196948 1196948 1108843 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345365 2345365 2210037 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047778 2047778 1928050 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1113046 1113046 1026547 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18458038 surgery - NOS NS 88 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228294 2228294 2096015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665718 2665718 2525427 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS recurrent 49 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1465888 1465888 1389735 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770534 1770534 1674774 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1498649 1498649 1421527 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21315472 surgery - NOS primary 85 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264094 2264094 2131078 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638758 1638758 1554757 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096127 2096127 1974191 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680508 2680508 2539781 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 50 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885175 1885175 1775062 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173408 1173408 1085492 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240667 2240667 2108198 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095917 2095917 1973981 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096277 2096277 1974341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095908 2095908 1973972 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838713 1838713 1732814 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264325 2264325 2131309 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1162969 1162969 1075292 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18992959 NS recurrent 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1042918 1042918 959259 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1567522 1567522 1489154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21949883 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924526 924526 841299 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1790529 1790529 1693508 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51771443 COSM12727 132551202 c.2416G>A p.V806I Substitution - Missense 38 7:55191800-55191800 + - PATHOGENIC .98898 Variant of unknown origin 16152581 fixed - NOS NS ENSP00000395243.3:p.Val806Ile ENST00000454757.6:c.2416G>A 7:g.55191800G>A EGFR ENST00000275493.6 3633 3236 1469388 1469388 1393127 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469373 1469373 1393112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459504 1459504 1383447 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1668661 1668661 1581953 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22523351 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246483 1246483 1158162 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2552471 2552471 2413912 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27553514 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336870 1336870 1247255 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705527 1705527 1613433 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1882531 1882531 1772666 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23486266 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1112968 1112968 1026479 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448997 surgery-fixed NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475389 1475389 1399088 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1599068 1599068 1519555 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22091430 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345426 2345426 2210098 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264132 2264132 2131116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770623 1770623 1674863 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618773 1618773 1537525 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777340 1777340 1681343 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1835502 1835502 1730534 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23242440 NS NS 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105801 2105801 1983839 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937594 1937594 1824528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983115 983115 898833 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960164 1960164 1846804 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2350427 2350427 2214798 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23357969 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422919 2422919 2285841 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2115443 2115443 1989687 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23915069 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1733683 1733683 1639632 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22836289 surgery-fixed NS 41 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1768461 1768461 1672701 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22952784 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290957 2290957 2157022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476876 2476876 2339645 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1284747 1284747 1196042 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 16467085 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-GE016-T1 2869741 2724738 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110479 COSM9796964 132610760 c.3194A>T p.Y1065F Substitution - Missense 38 7:55205313-55205313 + - PATHOGENIC .97664 Variant of unknown origin 26950094 surgery - NOS NS 77 ENSP00000395243.3:p.Tyr1065Phe ENST00000454757.6:c.3194A>T 7:g.55205313A>T EGFR ENST00000275493.6 3633 3236 2148513 2148513 2017643 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1964340 1964340 1850875 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1014123 1014123 931297 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1937511 1937511 1824445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141185 1141185 1053633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 18785203 autopsy-fixed NS 64 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1966320 1966320 1852813 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899316 899316 816928 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625553 2625553 2485965 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625553 2625553 2485965 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899319 899319 816931 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1593002 1593002 1513928 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345394 2345394 2210066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2552465 2552465 2413906 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27553514 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083795 1083795 998960 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118429 2118429 1992664 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444774 1444774 1369017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887422 1887422 1777094 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264429 2264429 2131413 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264429 2264429 2131413 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879557 1879557 1770059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-18-K10011 2905035 2759291 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864163 COSM10000367 132580595 c.407C>A p.P136H Substitution - Missense 38 7:55143471-55143471 + - PATHOGENIC .91703 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000395243.3:p.Pro136His ENST00000454757.6:c.407C>A 7:g.55143471C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983753 1983753 1869989 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668460 1668460 1581753 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-16-R00716 2905308 2759564 gastrointestinal_tract_(site_indeterminate) NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1530968 1530968 1453340 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1895070 1895070 1783762 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602807 1602807 1522143 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1320681 1320681 1231568 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20155428 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2046042 2046042 1926337 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1631938 1631938 1548808 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1705481 1705481 1613387 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1110458 1110458 1024336 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1731607 1731607 1637573 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 99377339 c.2239_2240delinsCC p.L747P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 22797155 fixed - NOS NS 59 ENSP00000275493.2:p.Leu747Pro ENST00000275493.6:c.2239_2240delinsCC 7:g.55174776_55174777delinsCC EGFR ENST00000275493.6 3633 3236 1246647 1246647 1158326 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226896 2226896 2094631 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 587256 1766760 1671080 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51771628 COSM1205054 133207482 c.1876C>T p.R626C Substitution - Missense 38 7:55173074-55173074 + - PATHOGENIC .99716 Reported in another cancer sample as somatic 22895193 surgery fresh/frozen primary ENSP00000415559.1:p.Arg626Cys ENST00000455089.5:c.1876C>T 7:g.55173074C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1813215 1813215 1712549 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23079729 surgery - NOS metastasis 42 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226863 2226863 2094598 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862713 2862713 2717876 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780877 COSM26717 133203719 c.2444A>T p.K815I Substitution - Missense 38 7:55191828-55191828 + - PATHOGENIC .95726 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Lys815Ile ENST00000455089.5:c.2444A>T 7:g.55191828A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862713 2862713 2717876 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770746 1770746 1674986 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879527 1879527 1770029 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1891282 1891282 1780651 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862784 2862784 2717947 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862784 2862784 2717947 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DM8 2466885 2329716 skin scalp NS NS malignant_melanoma desmoplastic NS NS n COSV51853062 COSM5611261 132555643 c.3002_3003delinsTT p.T1001I Substitution - Missense 38 7:55201757-55201758 + - Variant of unknown origin 26343386 surgery-fixed NS 81 ENSP00000395243.3:p.Thr1001Ile ENST00000454757.6:c.3002_3003delinsTT 7:g.55201757_55201758delinsTT EGFR ENST00000275493.6 3633 3236 2345103 2345103 2209775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2027802 2027802 1909705 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1585323 1585323 1506644 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22011666 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1964293 1964293 1850828 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM26140 178384130 c.? p.G729R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS EGFR ENST00000275493.6 3633 3236 1777301 1777301 1681304 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264371 2264371 2131355 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1994264 1994264 1879519 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23886169 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-95-7039-01 1914100 1802382 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51829394 COSM28515 132598432 c.2628C>A p.S876R Substitution - Missense 38 7:55198778-55198778 + - .69453 Variant of unknown origin 417 fresh/frozen - NOS primary 54 ENSP00000395243.3:p.Ser876Arg ENST00000454757.6:c.2628C>A 7:g.55198778C>A EGFR ENST00000275493.6 3633 3236 1731382 1731382 1637348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22457323 NS NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705490 1705490 1613396 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476878 2476878 2339647 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105810 2105810 1983848 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637133 1637133 1553181 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637119 1637119 1553167 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1862564 1862564 1753455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23352033 fine needle aspirate primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264127 2264127 2131111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891318 1891318 1780687 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 133206317 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Arg731His ENST00000455089.5:c.2192G>A 7:g.55181336G>A EGFR ENST00000275493.6 3633 3236 1729756 1729756 1635727 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22805266 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1672414 1672414 1585468 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21729655 surgery-fixed primary 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937585 1937585 1824519 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1541363 1541363 1463677 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM86998 178379356 c.? p.R776C Substitution - Missense + - Reported in another cancer sample as somatic 21768463 surgery - NOS NS ENSP00000275493.2:p.Arg776Cys EGFR ENST00000275493.6 3633 3236 1047003 1047003 963234 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1887411 1887411 1777083 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1435988 1435988 1345267 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen NS 48 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2823697 2823697 2679549 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31798692 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1043857 1043857 960198 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2482728 2482728 2345455 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26893581 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1635451 1635451 1551956 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22333554 surgery-fixed primary 45 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618853 1618853 1537605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469402 1469402 1393141 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1089598 1089598 1004545 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1892656 1892656 1781908 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23566546 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656986 1656986 1571641 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22338650 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 RPMI-8226 1092628 1007450 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS n COSV51773111 COSM13185 133203473 c.2117C>T p.T706I Substitution - Missense het 38 7:55174789-55174789 + - PATHOGENIC .99151 Reported in another cancer sample as somatic 18006781 cell-line NS ENSP00000415559.1:p.Thr706Ile ENST00000455089.5:c.2117C>T 7:g.55174789C>T EGFR ENST00000275493.6 3633 3236 1983775 1983775 1870011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264218 2264218 2131202 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046646 2046646 1926940 lung NS NS NS carcinoma NS NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1599065 1599065 1519552 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22091430 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1136886 1136886 1049450 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766618 COSM12374 99378740 c.2582T>G p.L861R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu861Arg ENST00000275493.6:c.2582T>G 7:g.55191831T>G EGFR ENST00000275493.6 3633 3236 1964340 1964340 1850875 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Glu709Lys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899328 899328 816940 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2026148 2026148 1908237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602796 1602796 1522132 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 907085 907085 824597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 UM-SCC-17B 2296307 2161910 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825836 COSM4599146 132572042 c.345T>A p.N115K Substitution - Missense 38 7:55143409-55143409 + - NEUTRAL .2671 Variant of unknown origin 25275298 cell-line NS 47 ENSP00000395243.3:p.Asn115Lys ENST00000454757.6:c.345T>A 7:g.55143409T>A EGFR ENST00000275493.6 3633 3236 1965865 1965865 1852358 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2033333 2033333 1914804 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24137465 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1884045 1884045 1773934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23495083 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479095 1479095 1402788 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983781 1983781 1870017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00329T00329 2857335 2712635 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983728 1983728 1869964 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077330 1077330 992584 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 999926 999926 917149 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16785471 surgery - NOS primary 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914958 1914958 1802960 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430060 1430060 1339478 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2819307 2819307 2675606 lung left_upper_lobe NS NS carcinoma invasive_mucinous_adenocarcinoma NS NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 30572543 circulating tumour NS 80 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042899 1042899 959240 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SH-437 1493307 1416297 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51773049 COSM22943 133204348 c.2408C>T p.P803L Substitution - Missense het 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 21372829 cell-line primary 49 ENSP00000415559.1:p.Pro803Leu ENST00000455089.5:c.2408C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 2096280 2096280 1974344 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2406823 2406823 2269703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096037 2096037 1974101 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095967 2095967 1974031 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468068 1468068 1391914 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 48 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096096 2096096 1974160 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549153 2549153 2410608 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895117 1895117 1783809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891265 1891265 1780634 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1088971 1088971 1003925 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17917328 cerebrospinal fluid metastasis 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098818 1098818 1013410 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51851382 COSM26437 133218216 c.2432T>C p.F811S Substitution - Missense 38 7:55191816-55191816 + - PATHOGENIC .97798 Variant of unknown origin 18176089 surgery fresh/frozen primary 50 ENSP00000415559.1:p.Phe811Ser ENST00000455089.5:c.2432T>C 7:g.55191816T>C EGFR ENST00000275493.6 3633 3236 1594596 1594596 1515564 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345350 2345350 2210022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1200920 1200920 1112810 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-18-M09457 2905536 2759792 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064720 2064720 1944797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2579304 2579304 2440641 NS NS NS NS malignant_melanoma NS NS NS n COSV51820036 COSM6005738 132583406 c.2288A>G p.N763S Substitution - Missense 38 7:55181432-55181432 + - PATHOGENIC .8643 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000395243.3:p.Asn763Ser ENST00000454757.6:c.2288A>G 7:g.55181432A>G EGFR ENST00000275493.6 3633 3236 1469806 1469806 1393545 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2581353 2581353 2442608 lung left NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 27923714 pleural effusion metastasis 42 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1965915 1965915 1852408 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1246487 1246487 1158166 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481259 1481259 1404888 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1967523 1967523 1854015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23807543 fixed - NOS metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096238 2096238 1974302 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469824 1469824 1393563 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2153072 2153072 2022082 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1774676 1774676 1678900 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22993320 surgery - NOS metastasis 57 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 3B 2529056 2390912 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery fresh/frozen metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1542155 1542155 1464458 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770555 1770555 1674795 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226184 2226184 2093919 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120917 1120917 1034073 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668463 1668463 1581756 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51787416 COSM219794 132554877 c.2364G>T p.L788F Substitution - Missense 38 7:55191748-55191748 + - PATHOGENIC .95793 Variant of unknown origin 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu788Phe ENST00000454757.6:c.2364G>T 7:g.55191748G>T EGFR ENST00000275493.6 3633 3236 2552054 2552054 2413495 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51776282 COSM1168015 99373518 c.2258C>T p.P753L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Reported in another cancer sample as somatic 26517354 surgery-fixed NS ENSP00000275493.2:p.Pro753Leu ENST00000275493.6:c.2258C>T 7:g.55174795C>T EGFR ENST00000275493.6 3633 3236 2402475 2402475 2265331 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 75 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2402475 2402475 2265331 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163060 2163060 2031644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469825 1469825 1393564 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2865555 2865555 2720685 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 29120087 surgery-fixed metastasis 45 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2227122 2227122 2094857 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25120654 surgery - NOS primary 77 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2538972 2538972 2400568 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 133205309 c.2104_2105delinsCC p.L702P Substitution - Missense het 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 27499993 surgery-fixed NS 61 ENSP00000415559.1:p.Leu702Pro ENST00000455089.5:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000455089 ENST00000455089.5 3276 3236 109600 2812903 2669317 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 46 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2081905 2081905 1960327 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081905 2081905 1960327 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025444 2025444 1907533 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 1484283 1484283 1407909 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21144613 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1450853 1450853 1374996 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469479 1469479 1393218 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471802 1471802 1395540 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51780206 COSM12373 133208468 c.2024C>T p.S675F Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .9768 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000415559.1:p.Ser675Phe ENST00000455089.5:c.2024C>T 7:g.55174018C>T EGFR ENST00000275493.6 3633 3236 1136862 1136862 1049426 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1014267 1014267 931441 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1746451 1746451 1651427 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 22895145 NS NS 73 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1246738 1246738 1158417 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1746450 1746450 1651426 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 22895145 NS NS 70 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2096239 2096239 1974303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450939 1450939 1375082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 46 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1991300 1991300 1876635 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-RT-S01813 1765244 1669564 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51848768 COSM383489 132591023 c.3250C>T p.H1084Y Substitution - Missense 38 7:55205369-55205369 + - PATHOGENIC .72456 Variant of unknown origin 22980975 surgery - NOS primary ENSP00000395243.3:p.His1084Tyr ENST00000454757.6:c.3250C>T 7:g.55205369C>T EGFR ENST00000275493.6 3633 3236 2345117 2345117 2209789 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1141317 1141317 1053765 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240550 2240550 2108081 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25227801 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421207 2421207 2284129 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203108 2203108 2071366 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777375 1777375 1681378 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1162977 1162977 1075300 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18992959 NS primary 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095912 2095912 1973976 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468882 1468882 1392621 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21128242 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1047909 1047909 964138 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17335935 pleural effusion primary 83 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425764 2425764 2288685 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983821 1983821 1870057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345093 2345093 2209765 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2264355 2264355 2131339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777286 1777286 1681289 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921948 1921948 1809266 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770706 1770706 1674946 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875347 1875347 1765930 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226768 2226768 2094503 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1498226 1498226 1421104 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21220471 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1042857 1042857 959198 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1777233 1777233 1681236 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173461 1173461 1085545 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19057271 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1500181 1500181 1423060 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2105806 2105806 1983844 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425739 2425739 2288660 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960162 1960162 1846802 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2156994 2156994 2025969 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1148666 1148666 1061107 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18829487 surgery-fixed NS 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469425 1469425 1393164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777300 1777300 1681303 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476886 2476886 2339655 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096068 2096068 1974132 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1531510 1531510 1453870 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21681119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148509 2148509 2017639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983152 983152 898870 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096077 2096077 1974141 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096054 2096054 1974118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774683 1774683 1678907 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS primary 87 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2151314 2151314 2020358 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24758910 NS NS 48 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264308 2264308 2131292 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2069150 2069150 1948725 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24346091 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637171 1637171 1553219 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667710 1667710 1581003 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676412 1676412 1589180 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493351 1493351 1416341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444756 1444756 1368999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425763 2425763 2288684 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2028988 2028988 1910870 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense hom + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264436 2264436 2131420 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515261 1515261 1437871 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1039717 1039717 956294 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 17051834 pleural effusion primary 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1487184 1487184 1410794 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21317742 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096218 2096218 1974282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096172 2096172 1974236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966319 1966319 1852812 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1036632 1036632 953389 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17201173 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2605904 2605904 2466866 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28271038 surgery - NOS metastasis 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142081 2142081 2011299 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618757 1618757 1537509 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 91 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705471 1705471 1613377 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1732346 1732346 1638312 lung right_lower_lobe NS NS carcinoma small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22129360 surgery - NOS recurrent 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095931 2095931 1973995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 999911 999911 917134 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16785471 surgery - NOS recurrent 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096185 2096185 1974249 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246638 1246638 1158317 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226139 2226139 2093874 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469509 1469509 1393248 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474349 2474349 2337118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045993 2045993 1926288 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774676 1774676 1678900 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS metastasis 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1074941 1074941 990195 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2549145 2549145 2410600 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891302 1891302 1780671 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1965897 1965897 1852390 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203094 2203094 2071352 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591072 1591072 1512188 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083072 1083072 998237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17685931 surgery-fixed NS 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264252 2264252 2131236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045964 2045964 1926259 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637121 1637121 1553169 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965843 1965843 1852336 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921939 1921939 1809257 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705491 1705491 1613397 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264357 2264357 2131341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173389 1173389 1085473 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096041 2096041 1974105 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1154312 1154312 1066648 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18957054 surgery-fixed NS 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081816 2081816 1960238 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481317 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887381 1887381 1777053 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887374 1887374 1777046 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734088 1734088 1640037 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22842370 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336829 1336829 1247214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2208169 2208169 2076402 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24992725 surgery-fixed primary 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1213654 1213654 1125521 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18978556 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638727 1638727 1554726 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000231 2000231 1885129 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008783 2008783 1891517 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095942 2095942 1974006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777337 1777337 1681340 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874752 1874752 1765343 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2136663 2136663 2006214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096087 2096087 1974151 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965278 1965278 1851773 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23803047 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731101 1731101 1637072 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22815900 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667712 1667712 1581005 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174302 1174302 1086321 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914910 1914910 1802912 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986163 1986163 1872399 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345354 2345354 2210026 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1876988 1876988 1767550 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453427 1453427 1377460 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1667642 1667642 1580937 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22534670 surgery-fixed NS 40 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1751710 1751710 1656526 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469812 1469812 1393551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1693733 1693733 1601960 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21729654 surgery-fixed primary 65 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1746677 1746677 1651653 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 80 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1136869 1136869 1049433 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 3638 915980 833379 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51866106 COSM13186 132616604 c.2120C>A p.S707Y Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98815 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000395243.3:p.Ser707Tyr ENST00000454757.6:c.2120C>A 7:g.55174792C>A EGFR ENST00000275493.6 3633 3236 2026215 2026215 1908304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768262 COSM26445 99377063 c.2300C>T p.A767V Substitution - Missense het 38 7:55181309-55181309 + - PATHOGENIC .97799 Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Ala767Val ENST00000275493.6:c.2300C>T 7:g.55181309C>T EGFR ENST00000275493.6 3633 3236 2264318 2264318 2131302 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 921163 921163 838122 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16002952 surgery-fixed primary 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1284672 1284672 1195967 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM28574 178384302 c.? p.P848L Substitution - Missense + - Reported in another cancer sample as somatic 16467085 surgery - NOS NS ENSP00000275493.2:p.Pro848Leu EGFR ENST00000275493.6 3633 3236 1547764 1547764 1469886 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 fine needle aspirate recurrent 60 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2148584 2148584 2017714 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302292 1302292 1213343 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239180 2239180 2106712 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 64 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239180 2239180 2106712 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103765 1103765 1018017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1444712 1444712 1368955 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591080 1591080 1512196 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551543 1551543 1473648 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1625789 1625789 1543013 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LUAD-E01014 1765085 1669405 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 60 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2402515 2402515 2265371 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009139 2009139 1891873 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990902 1990902 1876237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469422 1469422 1393161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 921173 921173 838132 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16002952 surgery-fixed primary 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096084 2096084 1974148 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983697 1983697 1869933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2579439 2579439 2440776 NS NS NS NS malignant_melanoma NS NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2579439 2579439 2440776 NS NS NS NS malignant_melanoma NS NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 OX-CO-2_R2_Cetux 2841377 2696927 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576981 COSM9396333 132600632 c.1338A>G p.I446M Substitution - Missense 38 7:55160313-55160313 + - NEUTRAL .12443 Variant of unknown origin 25623215 cell-line NS ENSP00000395243.3:p.Ile446Met ENST00000454757.6:c.1338A>G 7:g.55160313A>G EGFR ENST00000275493.6 3633 3236 1881380 1881380 1771531 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1891257 1891257 1780626 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2425736 2425736 2288657 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475395 1475395 1399094 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914925 1914925 1802927 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1107774 1107774 1021677 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602813 1602813 1522149 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897850 897850 815472 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51771864 COSM6226 133211629 c.2191C>T p.R731C Substitution - Missense 38 7:55181335-55181335 + - PATHOGENIC .97187 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Arg731Cys ENST00000455089.5:c.2191C>T 7:g.55181335C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897850 897850 815472 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51804843 COSM12429 133209145 c.2438_2439delinsGT p.L813R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438_2439delinsGT 7:g.55191822_55191823delinsGT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098817 1098817 1013409 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 51 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1430033 1430033 1339451 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336418 1336418 1246803 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20430469 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474452 2474452 2337221 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637104 1637104 1553152 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2509042 2509042 2371377 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 99378725 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 74 ENSP00000275493.2:p.Thr263Pro ENST00000275493.6:c.787A>C 7:g.55154050A>C EGFR ENST00000275493.6 3633 3236 2345084 2345084 2209756 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-150-tumor 2819055 2675354 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879508 1879508 1770010 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2156969 2156969 2025944 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2865685 2865685 2720761 lung right_upper_lobe NS NS carcinoma adenocarcinoma transformed_to_small_cell_carcinoma NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26384434 surgery - NOS metastasis 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1931641 1931641 1818931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264233 2264233 2131217 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637247 1637247 1553295 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1107790 1107790 1021693 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468060 1468060 1391906 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 57 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891244 1891244 1780613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136887 1136887 1049451 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226888 2226888 2094623 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166448 1166448 1078762 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51776171 COSM28605 132591561 c.2476G>A p.A826T Substitution - Missense het 38 7:55191860-55191860 + - PATHOGENIC .9853 Variant of unknown origin 16870303 surgery - NOS NS 33 ENSP00000395243.3:p.Ala826Thr ENST00000454757.6:c.2476G>A 7:g.55191860G>A EGFR ENST00000275493.6 3633 3236 1790525 1790525 1693504 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16152581 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1937528 1937528 1824462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046000 2046000 1926295 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1631961 1631961 1548831 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2000176 2000176 1885074 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163044 2163044 2031628 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891165 1891165 1780534 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625561 2625561 2485973 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 51 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895161 1895161 1783853 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2898403 2898403 2752681 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23800712 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2426847 2426847 2289768 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2426847 2426847 2289768 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879555 1879555 1770057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2161694 2161694 2030301 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24813888 surgery fresh/frozen recurrent 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2161694 2161694 2030301 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 24813888 surgery fresh/frozen recurrent 58 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103627 1103627 1017879 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 59 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KYSE510 2395007 2257838 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51828940 COSM3266631 132553646 c.1970C>A p.A657D Substitution - Missense 38 7:55173964-55173964 + - PATHOGENIC .97734 Variant of unknown origin 24686850 cell-line NS ENSP00000395243.3:p.Ala657Asp ENST00000454757.6:c.1970C>A 7:g.55173964C>A EGFR ENST00000275493.6 3633 3236 1599033 1599033 1519520 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 22091430 fixed - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2156366 2156366 2025374 lung left_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24752053 surgery - NOS primary 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618788 1618788 1537540 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 45 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2426839 2426839 2289760 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2426839 2426839 2289760 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM5010368 178378709 c.? p.C797S Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Cys797Ser EGFR ENST00000275493.6 3633 3236 1014326 1014326 931500 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu861Arg EGFR ENST00000275493.6 3633 3236 1278191 1278191 1189489 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729982 1729982 1635953 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1513415 1513415 1436076 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21497370 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2815032 2815032 2671420 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51787507 COSM13188 99385457 c.2281G>A p.D761N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 31400926 surgery-fixed NS 56 ENSP00000275493.2:p.Asp761Asn ENST00000275493.6:c.2281G>A 7:g.55174818G>A EGFR ENST00000275493.6 3633 3236 2027788 2027788 1909691 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027788 2027788 1909691 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1593026 1593026 1513952 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2205961 2205961 2074194 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983690 1983690 1869926 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875358 1875358 1765941 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1661840 1661840 1575453 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22487432 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014264 1014264 931438 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1590989 1590989 1512105 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897846 897846 815468 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2402750 2402750 2265603 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 26267891 surgery-fixed primary 72 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2345804 2345804 2210476 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1876998 1876998 1767560 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264176 2264176 2131160 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479920 1479920 1403580 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773712 COSM13433 133214162 c.2183A>G p.H728R Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98391 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.His728Arg ENST00000455089.5:c.2183A>G 7:g.55181327A>G EGFR ENST00000275493.6 3633 3236 897849 897849 815471 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 897849 897849 815471 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1996943 1996943 1882152 lung NS NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 35 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1996943 1996943 1882152 lung NS NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 35 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878783 2878783 2733298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22006985 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921933 1921933 1809251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1086843 1086843 1001862 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17848912 surgery-fixed NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1815285 1815285 1714456 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22896669 surgery - NOS recurrent 30 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226913 2226913 2094648 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51845318 COSM214350 133208295 c.2467G>A p.E823K Substitution - Missense 38 7:55191851-55191851 + - PATHOGENIC .98896 Variant of unknown origin 24891042 NS NS ENSP00000415559.1:p.Glu823Lys ENST00000455089.5:c.2467G>A 7:g.55191851G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675372 2675372 2534646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 133204348 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000415559.1:p.Pro803Leu ENST00000455089.5:c.2408C>T 7:g.55191792C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453491 1453491 1377524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00300T00300 2857355 2712655 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1467318 1467318 1391164 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 20940188 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1467318 1467318 1391164 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 20940188 surgery - NOS NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2421162 2421162 2284084 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1980079 1980079 1866322 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 71 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1768463 1768463 1672703 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22952784 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1097652 1097652 1012313 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996949 1996949 1882158 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 77 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1895087 1895087 1783779 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096042 2096042 1974106 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1892646 1892646 1781898 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23566546 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637231 1637231 1553279 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237675 1237675 1149422 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680558 2680558 2539831 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770680 1770680 1674920 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345046 2345046 2209718 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1891221 1891221 1780590 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042918 1042918 959259 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1098865 1098865 1013457 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1566871 1566871 1488678 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21881358 surgery - NOS primary 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2778597 2778597 2636651 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51859563 COSM6910210 99376263 c.2509G>A p.D837N Substitution - Missense 38 7:55191758-55191758 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000275493.2:p.Asp837Asn ENST00000275493.6:c.2509G>A 7:g.55191758G>A EGFR ENST00000275493.6 3633 3236 2878846 2878846 2733361 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27368130 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444711 1444711 1368954 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230467 1230467 1142281 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637183 1637183 1553231 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891189 1891189 1780558 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC2/Ad 946052 862578 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983820 1983820 1870056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136879 1136879 1049443 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302245 1302245 1213296 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS 39 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1310478 1310478 1221423 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429326 1429326 1338777 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1310469 1310469 1221414 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231327 1231327 1143117 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891208 1891208 1780577 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895106 1895106 1783798 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453433 1453433 1377466 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098871 1098871 1013463 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983732 1983732 1869968 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920161 920161 837241 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1188174 1188174 1100073 thyroid NS NS NS carcinoma papillary_carcinoma follicular_variant NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19253367 surgery-fixed primary 76 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067066 1067066 983046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1994213 1994213 1879468 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23897956 surgery - NOS metastasis 56 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924509 924509 841282 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1751715 1751715 1656531 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862078 2862078 2717283 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 32122695 circulating tumour metastasis 62 ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 1558204 1558204 1479575 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21835826 surgery - NOS primary 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264246 2264246 2131230 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045973 2045973 1926268 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1453428 1453428 1377461 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136880 1136880 1049444 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2277187 2277187 2143719 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25328676 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2277187 2277187 2143719 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25328676 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421156 2421156 2284078 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264124 2264124 2131108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1141185 1141185 1053633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 18785203 autopsy-fixed NS 64 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1638735 1638735 1554734 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476866 2476866 2339635 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2476866 2476866 2339635 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1077339 1077339 992593 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345536 2345536 2210208 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637708 2637708 2498081 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 circulating tumour recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2659796 2659796 2519954 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773049 COSM22943 99376120 c.2543C>T p.P848L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Pro848Leu ENST00000275493.6:c.2543C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 MG-043-tumor 2818993 2675292 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00005T00005 2857374 2712674 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1881386 1881386 1771537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1235341 178387389 c.? p.H773P Substitution - Missense + - Variant of unknown origin 23362162 surgery-fixed NS ENSP00000275493.2:p.His773Pro EGFR ENST00000275493.6 3633 3236 1098813 1098813 1013405 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 52 ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 1098813 1098813 1013405 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 52 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2264217 2264217 2131201 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777360 1777360 1681363 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474461 2474461 2337230 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469340 1469340 1393079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027348 2027348 1909416 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 52 ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1567522 1567522 1489154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21949883 fine needle aspirate metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-NYU184 1765199 1669519 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51830659 COSM370916 132577107 c.2435G>T p.G812V Substitution - Missense 38 7:55191819-55191819 + - PATHOGENIC .99007 Variant of unknown origin 22980975 surgery - NOS primary 77 ENSP00000395243.3:p.Gly812Val ENST00000454757.6:c.2435G>T 7:g.55191819G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105111181 COSM9542450 132574470 c.61G>A p.A21T Substitution - Missense 38 7:55019338-55019338 + - NEUTRAL .06121 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000395243.3:p.Ala21Thr ENST00000454757.6:c.61G>A 7:g.55019338G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602803 1602803 1522139 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00005T00005 2857374 2712674 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-043-tumor 2818993 2675292 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226896 2226896 2094631 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1498643 1498643 1421521 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21315472 surgery - NOS primary 84 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264225 2264225 2131209 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141288 1141288 1053736 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1516781 1516781 1439375 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21575212 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1112969 1112969 1026480 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448997 surgery-fixed NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1835521 1835521 1730553 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23242440 NS NS 82 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106559 2106559 1984422 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329265 1329265 1239750 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493339 1493339 1416329 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631938 1631938 1548808 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110458 1110458 1024336 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1731607 1731607 1637573 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 133205309 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 22797155 fixed - NOS NS 59 ENSP00000415559.1:p.Leu702Pro ENST00000455089.5:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1919304 1919304 1806625 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51803771 COSM14068 133219764 c.2173G>A p.D725N Substitution - Missense 38 7:55181317-55181317 + - PATHOGENIC .97623 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Asp725Asn ENST00000455089.5:c.2173G>A 7:g.55181317G>A EGFR ENST00000275493.6 3633 3236 1567521 1567521 1489153 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21949883 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136871 1136871 1049435 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1535037 1535037 1457372 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1732132 1732132 1638098 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21622214 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469858 1469858 1393597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469858 1469858 1393597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345522 2345522 2210194 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618626 1618626 1537378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 81 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618626 1618626 1537378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 81 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1112992 1112992 1026503 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448997 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593002 1593002 1513928 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1996934 1996934 1882143 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM28619 178383742 c.? p.V786M Substitution - Missense + - Variant of unknown origin 23912954 fixed - NOS NS 74 ENSP00000275493.2:p.Val786Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1047003 1047003 963234 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895070 1895070 1783762 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043857 1043857 960198 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1517598 1517598 1439976 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21573178 surgery fresh/frozen recurrent 63 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089598 1089598 1004545 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-17-G33297 2905054 2759310 NS NS NS NS malignant_melanoma NS NS NS n COSV105863803 COSM9997894 132616178 c.2951C>T p.T984M Substitution - Missense 38 7:55201327-55201327 + - PATHOGENIC .96845 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000395243.3:p.Thr984Met ENST00000454757.6:c.2951C>T 7:g.55201327C>T EGFR ENST00000275493.6 3633 3236 2096307 2096307 1974371 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096243 2096243 1974307 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2095949 2095949 1974013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2730698 2730698 2589469 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 99377339 c.2239_2240delinsCC p.L747P Substitution - Missense 38 7:55174776-55174777 + Yes Reported in another cancer sample as somatic 29673089 surgery-fixed recurrent 54 ENSP00000275493.2:p.Leu747Pro ENST00000275493.6:c.2239_2240delinsCC 7:g.55174776_55174777delinsCC EGFR ENST00000275493.6 3633 3236 1879552 1879552 1770054 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1237677 1237677 1149424 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983775 1983775 1870011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1435988 1435988 1345267 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen NS 48 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2095970 2095970 1974034 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203102 2203102 2071360 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2482733 2482733 2345460 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26893581 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542351 1542351 1464654 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1592883 1592883 1513809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1592883 1592883 1513809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162178 1162178 1074510 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768381 COSM28509 132553443 c.1988A>T p.K663M Substitution - Missense 38 7:55173982-55173982 + - PATHOGENIC .98216 Variant of unknown origin 19020901 NS NS ENSP00000395243.3:p.Lys663Met ENST00000454757.6:c.1988A>T 7:g.55173982A>T EGFR ENST00000275493.6 3633 3236 899340 899340 816952 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2778779 2778779 2636833 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 29066915 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1435969 1435969 1345248 lung right_lower_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen primary 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2011170 2011170 1893808 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444764 1444764 1369007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095952 2095952 1974016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345405 2345405 2210077 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895153 1895153 1783845 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2537656 2537656 2399297 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 27177916 circulating tumour recurrent 68 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2537656 2537656 2399297 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27177916 circulating tumour recurrent 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479952 1479952 1403612 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2026216 2026216 1908305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21945 178380161 c.? p.V802I Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Val802Ile EGFR ENST00000275493.6 3633 3236 1992087 1992087 1877404 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 42 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1179109 1179109 1091071 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19185949 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1973997 1973997 1860239 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345556 2345556 2210228 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2562082 2562082 2423478 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594596 1594596 1515564 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1200920 1200920 1112810 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879527 1879527 1770029 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891282 1891282 1780651 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1530993 1530993 1453365 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421208 2421208 2284130 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264101 2264101 2131085 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2759185 2759185 2617735 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour borderline NS n COSM1235342 178378585 c.? p.L62R Substitution - Missense + - Reported in another cancer sample as somatic 27566247 surgery-fixed NS ENSP00000275493.2:p.Leu62Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2552054 2552054 2413495 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51776282 COSM1168015 133202278 c.2123C>T p.P708L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Reported in another cancer sample as somatic 26517354 surgery-fixed NS ENSP00000415559.1:p.Pro708Leu ENST00000455089.5:c.2123C>T 7:g.55174795C>T EGFR ENST00000275493.6 3633 3236 2731046 2731046 2589813 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing_non_differentiated NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25963410 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2479705 2479705 2342451 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2148610 2148610 2017740 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547771 1547771 1469893 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed metastasis 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705533 1705533 1613439 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1705533 1705533 1613439 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2426834 2426834 2289755 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2064727 2064727 1944804 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 2064727 2064727 1944804 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2264269 2264269 2131253 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996928 1996928 1882137 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM28574 178384302 c.? p.P848L Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 40 ENSP00000275493.2:p.Pro848Leu EGFR ENST00000275493.6 3633 3236 2264430 2264430 2131414 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264430 2264430 2131414 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2906653 2906653 2760904 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29616327 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469804 1469804 1393543 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 907084 907084 824596 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096169 2096169 1974233 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729733 1729733 1635704 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 22805266 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1937564 1937564 1824498 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136862 1136862 1049426 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2346540 2346540 2211203 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986149 1986149 1872385 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1514595 1514595 1437205 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21558399 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1136894 1136894 1049458 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766618 COSM12374 99378740 c.2582T>G p.L861R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu861Arg ENST00000275493.6:c.2582T>G 7:g.55191831T>G EGFR ENST00000275493.6 3633 3236 2027806 2027806 1909709 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2271427 2271427 2138058 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25257380 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2_48 2039533 1920866 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 99376120 c.2543C>T p.P848L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 24158511 surgery fresh/frozen primary 78 ENSP00000275493.2:p.Pro848Leu ENST00000275493.6:c.2543C>T 7:g.55191792C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983821 1983821 1870057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862095 2862095 2717297 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51799562 COSM6854575 132572269 c.2906A>G p.D969G Substitution - Missense 38 7:55201282-55201282 + - PATHOGENIC .9951 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000395243.3:p.Asp969Gly ENST00000454757.6:c.2906A>G 7:g.55201282A>G EGFR ENST00000275493.6 3633 3236 1676413 1676413 1589181 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096167 2096167 1974231 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522945 1522945 1445317 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 50 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1535045 1535045 1457380 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345545 2345545 2210217 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638729 1638729 1554728 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774666 1774666 1678890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22993320 surgery - NOS metastasis 54 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1774666 1774666 1678890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS metastasis 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551485 1551485 1473590 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS 76 ENSP00000275493.2:p.Leu861Arg EGFR ENST00000275493.6 3633 3236 2239168 2239168 2106700 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25130612 surgery - NOS NS 39 ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659796 2659796 2519954 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773049 COSM22943 133204348 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Pro803Leu ENST00000455089.5:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625563 2625563 2485975 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 132553412 c.2477C>G p.A826G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 27056568 surgery-fixed NS 51 ENSP00000395243.3:p.Ala826Gly ENST00000454757.6:c.2477C>G 7:g.55191861C>G EGFR ENST00000275493.6 3633 3236 1921930 1921930 1809248 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2009163 2009163 1891897 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2239172 2239172 2106704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 58 ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 2239172 2239172 2106704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2426835 2426835 2289756 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2426835 2426835 2289756 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM5010368 178378709 c.? p.C797S Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Cys797Ser EGFR ENST00000275493.6 3633 3236 1980076 1980076 1866319 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 42 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1837425 1837425 1731624 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23242437 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2095962 2095962 1974026 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2426830 2426830 2289751 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469504 1469504 1393243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042857 1042857 959198 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1500181 1500181 1423060 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1074941 1074941 990195 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891302 1891302 1780671 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450853 1450853 1374996 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51841184 COSM1090877 132552664 c.1486C>A p.L496I Substitution - Missense het 38 7:55161621-55161621 + - NEUTRAL .01946 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000395243.3:p.Leu496Ile ENST00000454757.6:c.1486C>A 7:g.55161621C>A EGFR ENST00000275493.6 3633 3236 1587190 1587190 1508361 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85992 178378490 c.? p.E709A Substitution - Missense + - Variant of unknown origin 21841502 surgery-fixed NS 80 ENSP00000275493.2:p.Glu709Ala EGFR ENST00000275493.6 3633 3236 V169 1179750 1091712 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 42 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1751710 1751710 1656526 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1693733 1693733 1601960 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21729654 surgery-fixed primary 65 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-E01014 1765085 1669405 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 60 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2264197 2264197 2131181 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 897820 897820 815442 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2095900 2095900 1973964 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264160 2264160 2131144 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1592985 1592985 1513911 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1160968 1160968 1073304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19002495 surgery-fixed primary 48 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1512587 1512587 1435271 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21508367 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014321 1014321 931495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665706 2665706 2525415 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28978102 surgery - NOS recurrent 72 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2665706 2665706 2525415 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS recurrent 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469433 1469433 1393172 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136869 1136869 1049433 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2026215 2026215 1908304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768262 COSM26445 133205089 c.2165C>T p.A722V Substitution - Missense het 38 7:55181309-55181309 + - PATHOGENIC .97799 Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000415559.1:p.Ala722Val ENST00000455089.5:c.2165C>T 7:g.55181309C>T EGFR ENST00000275493.6 3633 3236 1837425 1837425 1731624 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23242437 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459497 1459497 1383440 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2898402 2898402 2752680 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23800712 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047747 2047747 1928019 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis 45 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1625789 1625789 1543013 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1881380 1881380 1771531 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1477704 1477704 1401403 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51848641 COSM85750 132583450 c.2168_2170delinsTCT p.S723_V724delinsIL Substitution - Missense 38 7:55181312-55181314 + - Variant of unknown origin 21052000 surgery fresh/frozen NS ENSP00000395243.3:p.Ser723_Val724delinsIleLeu ENST00000454757.6:c.2168_2170delinsTCT 7:g.55181312_55181314delinsTCT EGFR ENST00000275493.6 3633 3236 2862707 2862707 2717870 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1093896 1093896 1008598 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18061305 pleural effusion NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1029246 1029246 946117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16921488 pleural effusion NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493357 1493357 1416347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891257 1891257 1780626 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226138 2226138 2093873 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 897284 897284 814907 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 15118073 surgery-fixed primary 62 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2474347 2474347 2337116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515249 1515249 1437859 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1434027 1434027 1343442 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264331 2264331 2131315 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1931641 1931641 1818931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899355 899355 816967 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766584 COSM12371 132555223 c.1991A>T p.E664V Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97538 Variant of unknown origin 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Glu664Val ENST00000454757.6:c.1991A>T 7:g.55173985A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2579503 2579503 2440840 NS NS NS NS malignant_melanoma NS NS NS n COSV51849040 COSM6005740 132578560 c.353C>T p.A118V Substitution - Missense 38 7:55143417-55143417 + - PATHOGENIC .99538 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000395243.3:p.Ala118Val ENST00000454757.6:c.353C>T 7:g.55143417C>T EGFR ENST00000275493.6 3633 3236 2264372 2264372 2131356 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1444578 1444578 1368823 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20686428 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2810587 2810587 2667248 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51766268 COSM13183 99377562 c.2225T>C p.V742A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Reported in another cancer sample as somatic 31476386 surgery-fixed NS 67.2 ENSP00000275493.2:p.Val742Ala ENST00000275493.6:c.2225T>C 7:g.55174762T>C EGFR ENST00000275493.6 3633 3236 1246644 1246644 1158323 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2732920 2732920 2591673 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 99378725 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 73 ENSP00000275493.2:p.Thr263Pro ENST00000275493.6:c.787A>C 7:g.55154050A>C EGFR ENST00000275493.6 3633 3236 1430037 1430037 1339455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1790525 1790525 1693504 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16152581 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631961 1631961 1548831 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1732124 1732124 1638090 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21622214 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1077328 1077328 992582 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770673 1770673 1674913 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105823 2105823 1983861 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895161 1895161 1783853 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 NPC0001PT00296T00296 2857351 2712651 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1705488 1705488 1613394 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226159 2226159 2093894 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542159 1542159 1464462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1983696 1983696 1869932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1246626 1246626 1158305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1789305 1789305 1692709 lung NS NS NS carcinoma NS NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1789305 1789305 1692709 lung NS NS NS carcinoma NS NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-17-D48943 2905181 2759437 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864603 COSM9999789 132611372 c.2689G>A p.D897N Substitution - Missense 38 7:55198839-55198839 + - PATHOGENIC .9854 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000395243.3:p.Asp897Asn ENST00000454757.6:c.2689G>A 7:g.55198839G>A EGFR ENST00000275493.6 3633 3236 1039707 1039707 956284 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense het + - Reported in another cancer sample as somatic 17051834 pleural effusion primary 68 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1587202 1587202 1508373 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 TCGA-91-6847-01 1914094 1802376 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 62 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1077372 1077372 992626 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2345057 2345057 2209729 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593026 1593026 1513952 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983690 1983690 1869926 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875358 1875358 1765941 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1113001 1113001 1026509 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51780000 COSM27041 132564991 c.2078T>G p.V693G Substitution - Missense 38 7:55174750-55174750 + - PATHOGENIC .99814 Variant of unknown origin 18302229 surgery - NOS NS 68 ENSP00000395243.3:p.Val693Gly ENST00000454757.6:c.2078T>G 7:g.55174750T>G EGFR ENST00000275493.6 3633 3236 1618614 1618614 1537366 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 57 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618614 1618614 1537366 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1594593 1594593 1515561 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1535046 1535046 1457381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891198 1891198 1780567 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778597 2778597 2636651 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51859563 COSM6910210 133204470 c.2374G>A p.D792N Substitution - Missense 38 7:55191758-55191758 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000415559.1:p.Asp792Asn ENST00000455089.5:c.2374G>A 7:g.55191758G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1876998 1876998 1767560 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098865 1098865 1013457 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2156366 2156366 2025374 lung left_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24752053 surgery - NOS primary 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1444753 1444753 1368996 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1000817 1000817 918040 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 16983123 autopsy - NOS metastasis 53 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2361982 2361982 2224925 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25726043 NS NS 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011173 2011173 1893811 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2788069 2788069 2645487 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29308976 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1675619 1675619 1588499 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22560922 surgery-fixed primary 77 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895087 1895087 1783779 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2815032 2815032 2671420 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51787507 COSM13188 133213942 c.2146G>A p.D716N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 31400926 surgery-fixed NS 56 ENSP00000415559.1:p.Asp716Asn ENST00000455089.5:c.2146G>A 7:g.55174818G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891221 1891221 1780590 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897849 897849 815471 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897849 897849 815471 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980079 1980079 1866322 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 71 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2136613 2136613 2006164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS 54 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 NPC0001PT00177T00177 2857368 2712668 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1302286 1302286 1213337 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2105799 2105799 1983837 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1026459 1026459 943435 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17047654 surgery - NOS NS 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141302 1141302 1053750 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136880 1136880 1049444 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077339 1077339 992593 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471805 1471805 1395543 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51847909 COSM53228 132584181 c.1988A>G p.K663R Substitution - Missense 38 7:55173982-55173982 + - PATHOGENIC .98155 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000395243.3:p.Lys663Arg ENST00000454757.6:c.1988A>G 7:g.55173982A>G EGFR ENST00000275493.6 3633 3236 2525733 2525733 2387921 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 27304188 NS NS ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 1166446 1166446 1078760 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1637091 1637091 1553139 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542342 1542342 1464645 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777417 1777417 1681420 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469419 1469419 1393158 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1558204 1558204 1479575 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21835826 surgery - NOS primary 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098813 1098813 1013405 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 52 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098813 1098813 1013405 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 52 ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2027348 2027348 1909416 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 52 ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1107246 1107246 1021158 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 896926 896926 814549 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15329413 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1729974 1729974 1635945 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1859890 1859890 1750831 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23344087 surgery - NOS metastasis 47 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891203 1891203 1780572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2525733 2525733 2387921 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638760 1638760 1554759 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345583 2345583 2210255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637221 1637221 1553269 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2141438 2141438 2010656 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24636848 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2141438 2141438 2010656 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24636848 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1973998 1973998 1860240 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450934 1450934 1375077 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 49 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089603 1089603 1004550 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231313 1231313 1143103 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924524 924524 841297 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136889 1136889 1049453 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1054400 1054400 970471 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891245 1891245 1780614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110455 1110455 1024333 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NCI-H3255 897734 815356 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15118125 cell-line metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920130 920130 837210 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239189 2239189 2106721 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25134330 surgery - NOS NS 81 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009148 2009148 1891882 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1168011 1168011 1080253 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1884156 1884156 1774043 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1135424 1135424 1047988 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226880 2226880 2094615 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2422832 2422832 2285754 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422832 2422832 2285754 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547760 1547760 1469882 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 74 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 64 2786482 2643905 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51779794 COSM53264 99387824 c.2174C>T p.T725M Substitution - Missense 38 7:55174033-55174033 + - PATHOGENIC .97744 Reported in another cancer sample as somatic 30115035 surgery-fixed NS ENSP00000275493.2:p.Thr725Met ENST00000275493.6:c.2174C>T 7:g.55174033C>T EGFR ENST00000275493.6 3633 3236 1453436 1453436 1377469 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226891 2226891 2094626 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1729957 1729957 1635928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 surgery-fixed NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1074942 1074942 990196 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 80 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2214578 2214578 2082702 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1173462 1173462 1085546 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19057271 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2626119 2626119 2486531 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51779794 COSM53264 99387824 c.2174C>T p.T725M Substitution - Missense 38 7:55174033-55174033 + - PATHOGENIC .97744 Reported in another cancer sample as somatic 26645239 surgery-fixed NS ENSP00000275493.2:p.Thr725Met ENST00000275493.6:c.2174C>T 7:g.55174033C>T EGFR ENST00000275493.6 3633 3236 G9 1063233 979278 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 63 ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 G9 1063233 979278 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453428 1453428 1377461 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1567521 1567521 1489153 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21949883 fine needle aspirate metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136871 1136871 1049435 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1330082 1330082 1240567 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51809790 COSM41665 132552988 c.2366T>C p.V789A Substitution - Missense 38 7:55191750-55191750 + - PATHOGENIC .97813 Variant of unknown origin 20208477 surgery - NOS NS ENSP00000395243.3:p.Val789Ala ENST00000454757.6:c.2366T>C 7:g.55191750T>C EGFR ENST00000275493.6 3633 3236 2226914 2226914 2094649 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 2032217 2032217 1913688 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1047963 1047963 964191 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM23617 178385408 c.? p.T785I Substitution - Missense + - Reported in another cancer sample as somatic 17337084 surgery-fixed NS ENSP00000275493.2:p.Thr785Ile EGFR ENST00000275493.6 3633 3236 1777287 1777287 1681290 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2595752 2595752 2456628 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1028977 1028977 945848 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM21945 178380161 c.? p.V802I Substitution - Missense + - Reported in another cancer sample as somatic 17062680 surgery-fixed NS ENSP00000275493.2:p.Val802Ile EGFR ENST00000275493.6 3633 3236 1937562 1937562 1824496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444728 1444728 1368971 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875346 1875346 1765929 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264347 2264347 2131331 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226914 2226914 2094649 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 924510 924510 841283 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1223892 1223892 1135724 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19517135 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1024765 1024765 941742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1110742 1110742 1024620 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18325048 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895169 1895169 1783861 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2203092 2203092 2071350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2396139 2396139 2258970 lung left_bronchus NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24942894 fine needle aspirate recurrent 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2396139 2396139 2258970 lung left_bronchus NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 24942894 fine needle aspirate recurrent 70 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1434758 1434758 1344116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20813423 surgery - NOS primary 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1486483 1486483 1410101 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21107288 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1751711 1751711 1656527 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2032218 2032218 1913689 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2226879 2226879 2094614 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 NPC0001PT00204T00204 2857356 2712656 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2264104 2264104 2131088 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891206 1891206 1780575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2778775 2778775 2636829 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1113000 1113000 1026509 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51780000 COSM27041 132564991 c.2078T>G p.V693G Substitution - Missense 38 7:55174750-55174750 + - PATHOGENIC .99814 Variant of unknown origin 18302229 surgery - NOS NS 68 ENSP00000395243.3:p.Val693Gly ENST00000454757.6:c.2078T>G 7:g.55174750T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-18-T42044 2905562 2759818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864537 COSM10001654 132603087 c.3109A>T p.I1037L Substitution - Missense 38 7:55202598-55202598 + - NEUTRAL .15191 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Ile1037Leu ENST00000454757.6:c.3109A>T 7:g.55202598A>T EGFR ENST00000275493.6 3633 3236 2525718 2525718 2387906 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525718 2525718 2387906 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2906652 2906652 2760903 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29616327 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1637235 1637235 1553283 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1707036 1707036 1614942 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22695392 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1076402 1076402 991656 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17607119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921731 1921731 1809049 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense hom + - Reported in another cancer sample as somatic 23620765 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 711 1716350 1623912 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22733594 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1592999 1592999 1513925 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2659807 2659807 2519965 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1036705 1036705 953462 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17106442 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469395 1469395 1393134 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096285 2096285 1974349 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1777391 1777391 1681394 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 AMO1 1889514 1778954 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV51777457 COSM1236015 132570365 c.492A>C p.K164N Substitution - Missense 38 7:55151361-55151361 + - NEUTRAL .14933 Variant of unknown origin 23396385 cell-line NS ENSP00000395243.3:p.Lys164Asn ENST00000454757.6:c.492A>C 7:g.55151361A>C EGFR ENST00000275493.6 3633 3236 1983743 1983743 1869979 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2425740 2425740 2288661 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179653 1179653 1091615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106547 2106547 1984410 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1990895 1990895 1876230 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1937552 1937552 1824486 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148595 2148595 2017725 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095892 2095892 1973956 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226168 2226168 2093903 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1566948 1566948 1488717 upper_aerodigestive_tract pharynx hypopharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51804843 COSM12429 99380902 c.2573_2574delinsGT p.L858R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 21953075 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573_2574delinsGT 7:g.55191822_55191823delinsGT EGFR ENST00000275493.6 3633 3236 2862078 2862078 2717283 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 32122695 circulating tumour metastasis 62 ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 897808 897808 815430 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1705523 1705523 1613429 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960178 1960178 1846818 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680660 2680660 2539933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2479703 2479703 2342449 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1667716 1667716 1581009 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1770607 1770607 1674847 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 897821 897821 815443 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1075907 1075907 991161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 99396060 c.2281G>T p.D761Y Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99554 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000275493.2:p.Asp761Tyr ENST00000275493.6:c.2281G>T 7:g.55174818G>T EGFR ENST00000275493.6 3633 3236 2422911 2422911 2285833 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345091 2345091 2209763 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2096210 2096210 1974274 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345550 2345550 2210222 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345466 2345466 2210138 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264338 2264338 2131322 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879524 1879524 1770026 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1246669 1246669 1158348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 916965 916965 834346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16052537 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2730698 2730698 2589469 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 133205309 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + Yes Reported in another cancer sample as somatic 29673089 surgery-fixed recurrent 54 ENSP00000415559.1:p.Leu702Pro ENST00000455089.5:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879552 1879552 1770054 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1086837 1086837 1001859 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17848912 surgery-fixed NS 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2032240 2032240 1913711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1174311 1174311 1086330 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770569 1770569 1674809 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983833 1983833 1870069 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2011171 2011171 1893809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000153 2000153 1885051 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046069 2046069 1926364 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264279 2264279 2131263 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838705 1838705 1732806 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1435969 1435969 1345248 lung right_lower_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen primary 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MKN45 983727 899445 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51809237 COSM18445 132551621 c.3008C>T p.A1003V Substitution - Missense het 38 7:55201763-55201763 + - NEUTRAL .41771 Variant of unknown origin 16596188 cell-line NS ENSP00000395243.3:p.Ala1003Val ENST00000454757.6:c.3008C>T 7:g.55201763C>T EGFR ENST00000275493.6 3633 3236 2153077 2153077 2022087 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 921170 921170 838129 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16002952 surgery-fixed primary 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096123 2096123 1974187 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891209 1891209 1780578 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1990909 1990909 1876244 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345120 2345120 2209792 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KARPAS45 1760525 1665128 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51767338 COSM327145 132559277 c.227T>C p.L76P Substitution - Missense 38 7:55142424-55142424 + - PATHOGENIC .97399 Variant of unknown origin 22675565 cell-line NS ENSP00000395243.3:p.Leu76Pro ENST00000454757.6:c.227T>C 7:g.55142424T>C EGFR ENST00000275493.6 3633 3236 1141289 1141289 1053737 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1661848 1661848 1575461 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22487432 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2625550 2625550 2485962 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1637207 1637207 1553255 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095928 2095928 1973992 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141281 1141281 1053729 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 897836 897836 815458 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469462 1469462 1393201 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2905785 2905785 2760037 meninges NS NS NS meningioma NS NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 31872418 surgery - NOS NS ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 2905785 2905785 2760037 meninges NS NS NS meningioma NS NS NS n COSM34166 178380439 c.? p.R108K Substitution - Missense + - Reported in another cancer sample as somatic 31872418 surgery - NOS NS ENSP00000275493.2:p.Arg108Lys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592883 1592883 1513809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592883 1592883 1513809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 946820 946820 863343 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773889 COSM14069 132579420 c.2213C>T p.T738I Substitution - Missense 38 7:55181357-55181357 + - PATHOGENIC .96109 Variant of unknown origin 16204011 surgery-fixed NS ENSP00000395243.3:p.Thr738Ile ENST00000454757.6:c.2213C>T 7:g.55181357C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1094000 1094000 1008702 urinary_tract bladder NS NS carcinoma NS NS NS n COSV51833668 COSM12675 132590886 c.2440G>A p.A814T Substitution - Missense 38 7:55191824-55191824 + - PATHOGENIC .98898 Variant of unknown origin 17707060 surgery fresh/frozen NS ENSP00000395243.3:p.Ala814Thr ENST00000454757.6:c.2440G>A 7:g.55191824G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489065 1489065 1412385 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51778677 COSM85994 132612704 c.2441C>A p.A814D Substitution - Missense het 38 7:55191825-55191825 + - PATHOGENIC .98386 Variant of unknown origin 21317745 surgery-fixed NS 59 ENSP00000395243.3:p.Ala814Asp ENST00000454757.6:c.2441C>A 7:g.55191825C>A EGFR ENST00000275493.6 3633 3236 1895120 1895120 1783812 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1112972 1112972 1026483 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448997 surgery-fixed NS 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141314 1141314 1053762 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226914 2226914 2094649 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777782 COSM6227 99381636 c.2504A>T p.H835L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.His835Leu ENST00000275493.6:c.2504A>T 7:g.55191753A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895153 1895153 1783845 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1671448 1671448 1584650 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22197614 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096051 2096051 1974115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1860428 1860428 1751369 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302291 1302291 1213342 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345385 2345385 2210057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638759 1638759 1554758 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026147 2026147 1908236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 2264223 2264223 2131207 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402528 2402528 2265384 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264323 2264323 2131307 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1481248 1481248 1404877 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1965845 1965845 1852338 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637143 1637143 1553191 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862862 2862862 2718024 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29489023 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1481221 1481221 1404850 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2680562 2680562 2539835 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 50 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205980 2205980 2074213 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TMIT_I_12 2765652 2623896 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV99034441 COSM7346604 132555584 c.988G>A p.A330T Substitution - Missense 38 7:55156649-55156649 + - PATHOGENIC .97686 Variant of unknown origin 30239046 surgery-fixed NS ENSP00000395243.3:p.Ala330Thr ENST00000454757.6:c.988G>A 7:g.55156649G>A EGFR ENST00000275493.6 3633 3236 1966330 1966330 1852823 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731700 1731700 1637666 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22806307 NS NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402483 2402483 2265339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 58 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2402483 2402483 2265339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422792 2422792 2285714 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549127 2549127 2410582 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096252 2096252 1974316 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2862111 2862111 2717313 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51788393 COSM13979 99391974 c.2170G>A p.G724S Substitution - Missense 38 7:55174029-55174029 + - PATHOGENIC .98273 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000275493.2:p.Gly724Ser ENST00000275493.6:c.2170G>A 7:g.55174029G>A EGFR ENST00000275493.6 3633 3236 1618628 1618628 1537380 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 85 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264200 2264200 2131184 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246674 1246674 1158353 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844332 1844332 1737366 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1658060 1658060 1572505 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22458769 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1990904 1990904 1876239 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1173403 1173403 1085487 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1036701 1036701 953458 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17106442 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1835506 1835506 1730538 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23242440 NS NS 81 ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899340 899340 816952 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1992087 1992087 1877404 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 42 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1522945 1522945 1445317 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 50 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162179 1162179 1074511 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51785698 COSM28510 132588338 c.2027G>C p.G676A Substitution - Missense 38 7:55174021-55174021 + - PATHOGENIC .98515 Variant of unknown origin 19020901 NS NS ENSP00000395243.3:p.Gly676Ala ENST00000454757.6:c.2027G>C 7:g.55174021G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 912834 912834 830326 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51813062 COSM12764 132548042 c.2434G>A p.G812R Substitution - Missense het 38 7:55191818-55191818 + - PATHOGENIC .98898 Variant of unknown origin 15863375 surgery-fixed primary 75 ENSP00000395243.3:p.Gly812Arg ENST00000454757.6:c.2434G>A 7:g.55191818G>A EGFR ENST00000275493.6 3633 3236 2076960 2076960 1955709 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed recurrent 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996576 1996576 1881785 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23922984 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278185 1278185 1189483 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173401 1173401 1085485 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879532 1879532 1770034 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1973997 1973997 1860239 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924349 924349 841124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51801258 COSM13553 132560226 c.2437_2438inv p.L813R Substitution - Missense 38 7:55191821-55191822 + - Variant of unknown origin 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2437_2438inv 7:g.55191821_55191822inv EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2860650 2860650 2715938 central_nervous_system choroid_plexus NS NS other choroid_plexus_papilloma NS NS n COSV51813062 COSM12764 132548042 c.2434G>A p.G812R Substitution - Missense 38 7:55191818-55191818 + - PATHOGENIC .98898 Variant of unknown origin 31612017 surgery-fixed NS 3 ENSP00000395243.3:p.Gly812Arg ENST00000454757.6:c.2434G>A 7:g.55191818G>A EGFR ENST00000275493.6 3633 3236 1535054 1535054 1457389 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118421 2118421 1992656 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000271 2000271 1885169 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 9VWJAP 2762757 2621016 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51826193 COSM7340403 99392671 c.458A>G p.N153S Substitution - Missense 38 7:55146639-55146639 + - PATHOGENIC .99355 Reported in another cancer sample as somatic 29615459 NS NS 71 ENSP00000275493.2:p.Asn153Ser ENST00000275493.6:c.458A>G 7:g.55146639A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2479705 2479705 2342451 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 RDES 2294586 2160613 bone NS NS NS Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour NS NS NS y COSV51793186 COSM4587483 132590346 c.1663A>G p.M555V Substitution - Missense 38 7:55165355-55165355 + - PATHOGENIC .89999 Variant of unknown origin 25186949 cell-line NS ENSP00000395243.3:p.Met555Val ENST00000454757.6:c.1663A>G 7:g.55165355A>G EGFR ENST00000275493.6 3633 3236 1777305 1777305 1681308 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525743 2525743 2387931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 V197 1179751 1091713 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136894 1136894 1049458 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766618 COSM12374 133206840 c.2447T>G p.L816R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu816Arg ENST00000455089.5:c.2447T>G 7:g.55191831T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2_48 2039533 1920866 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 133204348 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 24158511 surgery fresh/frozen primary 78 ENSP00000415559.1:p.Pro803Leu ENST00000455089.5:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CC34 2766428 2624647 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV99034450 COSM7342223 132589690 c.2663T>C p.L888P Substitution - Missense 38 7:55198813-55198813 + - PATHOGENIC .98175 Variant of unknown origin 29844865 surgery fresh/frozen NS 69 ENSP00000395243.3:p.Leu888Pro ENST00000454757.6:c.2663T>C 7:g.55198813T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471812 1471812 1395550 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51780223 COSM28511 132566687 c.1973T>C p.L658P Substitution - Missense 38 7:55173967-55173967 + - PATHOGENIC .90657 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000395243.3:p.Leu658Pro ENST00000454757.6:c.1973T>C 7:g.55173967T>C EGFR ENST00000275493.6 3633 3236 1635370 1635370 1551875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22335887 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2675401 2675401 2534675 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1530991 1530991 1453363 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966316 1966316 1852809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345582 2345582 2210254 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637228 1637228 1553276 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960163 1960163 1846803 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842975 1842975 1736223 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009163 2009163 1891897 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239172 2239172 2106704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239172 2239172 2106704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 58 ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980076 1980076 1866319 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 42 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2000162 2000162 1885060 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468081 1468081 1391927 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 75 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096133 2096133 1974197 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239168 2239168 2106700 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 133206317 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 39 ENSP00000415559.1:p.Arg731His ENST00000455089.5:c.2192G>A 7:g.55181336G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897820 897820 815442 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592985 1592985 1513911 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1160968 1160968 1073304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19002495 surgery-fixed primary 48 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 907084 907084 824596 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1542362 1542362 1464665 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 21782507 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2105795 2105795 1983833 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770714 1770714 1674954 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345028 2345028 2209700 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 25668120 NS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 V169 1179750 1091712 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 42 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 22 1433987 1343402 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 79 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264126 2264126 2131110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862707 2862707 2717870 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1093896 1093896 1008598 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18061305 pleural effusion NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2132034 2132034 2006097 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24429877 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547758 1547758 1469880 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 66 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1547758 1547758 1469880 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1612904 1612904 1532132 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18083107 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1823857 1823857 1722251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23212424 surgery-fixed primary 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676427 1676427 1589195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1534803 1534803 1457140 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21684626 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2823699 2823699 2679551 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 31798692 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2426854 2426854 2289775 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2426854 2426854 2289775 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637160 1637160 1553208 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891235 1891235 1780604 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875381 1875381 1765964 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1966326 1966326 1852819 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838653 1838653 1732754 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451766 1451766 1375815 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20615575 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1110470 1110470 1024348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1963279 1963279 1849827 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23599349 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921949 1921949 1809267 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897284 897284 814907 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 15118073 surgery-fixed primary 62 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2810587 2810587 2667248 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51766268 COSM13183 133205606 c.2090T>C p.V697A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Reported in another cancer sample as somatic 31476386 surgery-fixed NS 67.2 ENSP00000415559.1:p.Val697Ala ENST00000455089.5:c.2090T>C 7:g.55174762T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1434027 1434027 1343442 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1038993 1038993 955570 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2142069 2142069 2011287 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081938 2081938 1960360 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24440279 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2345096 2345096 2209768 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2264329 2264329 2131313 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1860418 1860418 1751359 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983822 1983822 1870058 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469505 1469505 1393244 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2156947 2156947 2025922 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS 79 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2156947 2156947 2025922 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346484 2346484 2211147 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637220 1637220 1553268 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077328 1077328 992582 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2860650 2860650 2715938 central_nervous_system choroid_plexus NS NS other choroid_plexus_papilloma NS NS n COSV105110915 COSM9568329 132580546 c.3128C>T p.P1043L Substitution - Missense 38 7:55202617-55202617 + - PATHOGENIC .97375 Variant of unknown origin 31612017 surgery-fixed NS 3 ENSP00000395243.3:p.Pro1043Leu ENST00000454757.6:c.3128C>T 7:g.55202617C>T EGFR ENST00000275493.6 3633 3236 1223901 1223901 1135733 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19517135 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885193 1885193 1775080 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2778781 2778781 2636835 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 29066915 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2421157 2421157 2284079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00296T00296 2857351 2712651 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732920 2732920 2591673 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 133206822 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 73 ENSP00000415559.1:p.Thr218Pro ENST00000455089.5:c.652A>C 7:g.55154050A>C EGFR ENST00000275493.6 3633 3236 1973998 1973998 1860240 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1110455 1110455 1024333 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2009148 2009148 1891882 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 NCI-H3255 897734 815356 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15118125 cell-line metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 896926 896926 814549 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15329413 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1135424 1135424 1047988 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1884156 1884156 1774043 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920130 920130 837210 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1089603 1089603 1004550 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1231313 1231313 1143103 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136889 1136889 1049453 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924524 924524 841297 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1054400 1054400 970471 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1168011 1168011 1080253 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450934 1450934 1375077 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 49 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891245 1891245 1780614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226880 2226880 2094615 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2239189 2239189 2106721 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25134330 surgery - NOS NS 81 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1107246 1107246 1021158 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594593 1594593 1515561 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983696 1983696 1869932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1789305 1789305 1692709 lung NS NS NS carcinoma NS NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1789305 1789305 1692709 lung NS NS NS carcinoma NS NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2689570 2689570 2548547 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS n COSV51806541 COSM6904300 132558278 c.2869A>G p.M957V Substitution - Missense het 38 7:55201245-55201245 + - PATHOGENIC .98099 Variant of unknown origin 27246973 blood-bone marrow primary 37 ENSP00000395243.3:p.Met957Val ENST00000454757.6:c.2869A>G 7:g.55201245A>G EGFR ENST00000275493.6 3633 3236 2595755 2595755 2456631 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2264103 2264103 2131087 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008794 2008794 1891528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881921 1881921 1772072 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2107338 2107338 1985201 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770667 1770667 1674907 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891198 1891198 1780567 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1047909 1047909 964138 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17335935 pleural effusion primary 83 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2239189 2239189 2106721 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 25134330 surgery - NOS NS 81 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1336839 1336839 1247224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1077340 1077340 992594 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1637165 1637165 1553213 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770541 1770541 1674781 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00177T00177 2857368 2712668 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-273-tumor 2819121 2675420 meninges NS NS NS meningioma anaplastic NS NS n COSV104369217 COSM9267459 132578678 c.1279G>A p.A427T Substitution - Missense 38 7:55160254-55160254 + - PATHOGENIC .94147 Variant of unknown origin 28713588 surgery - NOS NS ENSP00000395243.3:p.Ala427Thr ENST00000454757.6:c.1279G>A 7:g.55160254G>A EGFR ENST00000275493.6 3633 3236 1196944 1196944 1108839 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444575 1444575 1368820 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20686428 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047737 2047737 1928009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469476 1469476 1393215 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046619 2046619 1926913 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345511 2345511 2210183 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246650 1246650 1158329 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1484653 1484653 1408279 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21274533 surgery - NOS primary 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1990914 1990914 1876249 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2319474 2319474 2184631 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM4766152 178379591 c.? p.R324L Substitution - Missense + - Reported in another cancer sample as somatic 25529192 surgery - NOS primary ENSP00000275493.2:p.Arg324Leu EGFR ENST00000275493.6 3633 3236 2644117 2644117 2504404 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166446 1166446 1078760 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1000817 1000817 918040 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 16983123 autopsy - NOS metastasis 53 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302286 1302286 1213337 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1542157 1542157 1464460 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2076940 2076940 1955689 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24369725 surgery-fixed recurrent 64 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1052972 1052972 969043 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17410005 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2732919 2732919 2591672 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 99378725 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 73 ENSP00000275493.2:p.Thr263Pro ENST00000275493.6:c.787A>C 7:g.55154050A>C EGFR ENST00000275493.6 3633 3236 1879533 1879533 1770035 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1887365 1887365 1777037 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 64 2786482 2643905 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51779794 COSM53264 133215961 c.2039C>T p.T680M Substitution - Missense 38 7:55174033-55174033 + - PATHOGENIC .97744 Reported in another cancer sample as somatic 30115035 surgery-fixed NS ENSP00000415559.1:p.Thr680Met ENST00000455089.5:c.2039C>T 7:g.55174033C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453436 1453436 1377469 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226891 2226891 2094626 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1430030 1430030 1339448 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345384 2345384 2210056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1456556 1456556 1380531 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096034 2096034 1974098 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027796 2027796 1909699 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2271422 2271422 2138056 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25257380 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493338 1493338 1416328 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1154304 1154304 1066640 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18957054 surgery-fixed NS 81 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469796 1469796 1393535 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1838671 1838671 1732772 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1074942 1074942 990196 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 80 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891203 1891203 1780572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 G9 1063233 979278 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 G9 1063233 979278 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 63 ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875346 1875346 1765929 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1194729 1194729 1106624 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1838656 1838656 1732757 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1319151 1319151 1230050 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20146086 surgery - NOS recurrent 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1319151 1319151 1230050 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 20146086 surgery - NOS recurrent 54 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2046068 2046068 1926363 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777241 1777241 1681244 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2064703 2064703 1944780 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 946824 946824 863347 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 MG-103-tumor 2819029 2675328 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1770538 1770538 1674778 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-49-4494-01 1780138 1684137 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 77 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924510 924510 841283 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1024765 1024765 941742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 surgery-fixed recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 587376 1766805 1671125 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51771628 COSM1205054 133207482 c.1876C>T p.R626C Substitution - Missense 38 7:55173074-55173074 + - PATHOGENIC .99716 Reported in another cancer sample as somatic 22895193 surgery fresh/frozen primary ENSP00000415559.1:p.Arg626Cys ENST00000455089.5:c.1876C>T 7:g.55173074C>T EGFR ENST00000275493.6 3633 3236 TCGA-49-4494-01 1780138 1684137 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 77 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2029023 2029023 1910905 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402474 2402474 2265330 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 75 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2402474 2402474 2265330 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476884 2476884 2339653 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1751711 1751711 1656527 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226879 2226879 2094614 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2046072 2046072 1926367 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875676 1875676 1766259 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729983 1729983 1635954 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 22 1596832 1517545 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20093389 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770655 1770655 1674895 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469397 1469397 1393136 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475377 1475377 1399076 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469391 1469391 1393130 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1981026 1981026 1867262 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1966322 1966322 1852815 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345059 2345059 2209731 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 921161 921161 838120 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16002952 surgery-fixed primary 74 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2396139 2396139 2258970 lung left_bronchus NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24942894 fine needle aspirate recurrent 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2396139 2396139 2258970 lung left_bronchus NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 24942894 fine needle aspirate recurrent 70 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778775 2778775 2636829 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136886 1136886 1049450 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766618 COSM12374 133206840 c.2447T>G p.L816R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu816Arg ENST00000455089.5:c.2447T>G 7:g.55191831T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00204T00204 2857356 2712656 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592981 1592981 1513907 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51858252 COSM133205 132594860 c.2375A>G p.D792G Substitution - Missense 38 7:55191759-55191759 + - PATHOGENIC .986 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000395243.3:p.Asp792Gly ENST00000454757.6:c.2375A>G 7:g.55191759A>G EGFR ENST00000275493.6 3633 3236 2345357 2345357 2210029 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336840 1336840 1247225 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2157027 2157027 2026002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2867472 2867472 2722544 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 32441866 surgery - NOS NS 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2865236 2865236 2720366 lung right_lower_lobe NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29675860 surgery - NOS primary 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1112971 1112971 1026482 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 18448997 surgery-fixed NS 72 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1517886 1517886 1440264 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM30754 178378833 c.? p.L747P Substitution - Missense + - Reported in another cancer sample as somatic 21572125 fine needle aspirate NS 60 ENSP00000275493.2:p.Leu747Pro EGFR ENST00000275493.6 3633 3236 2046647 2046647 1926941 lung NS NS NS carcinoma NS NS NS n COSM30754 178378833 c.? p.L747P Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu747Pro EGFR ENST00000275493.6 3633 3236 2025409 2025409 1907498 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983730 1983730 1869966 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2095971 2095971 1974035 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891206 1891206 1780575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895169 1895169 1783861 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592999 1592999 1513925 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659807 2659807 2519965 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983743 1983743 1869979 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1113001 1113001 1026509 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51780009 COSM27042 132564997 c.2147A>G p.D716G Substitution - Missense 38 7:55174819-55174819 + - PATHOGENIC .9946 Variant of unknown origin 18302229 surgery - NOS NS 68 ENSP00000395243.3:p.Asp716Gly ENST00000454757.6:c.2147A>G 7:g.55174819A>G EGFR ENST00000275493.6 3633 3236 2525734 2525734 2387922 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 2525734 2525734 2387922 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525734 2525734 2387922 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 3A 2529055 2390911 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990895 1990895 1876230 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2479703 2479703 2342449 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2029001 2029001 1910883 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1623718 1623718 1541305 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21615826 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1075010 1075010 990264 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1484654 1484654 1408280 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21274533 cerebrospinal fluid metastasis 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469356 1469356 1393095 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1067064 1067064 983044 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1638763 1638763 1554762 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425716 2425716 2288637 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1566948 1566948 1488717 upper_aerodigestive_tract pharynx hypopharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51804843 COSM12429 133209145 c.2438_2439delinsGT p.L813R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 21953075 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438_2439delinsGT 7:g.55191822_55191823delinsGT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897821 897821 815443 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1075907 1075907 991161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 133222251 c.2146G>T p.D716Y Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99554 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000415559.1:p.Asp716Tyr ENST00000455089.5:c.2146G>T 7:g.55174818G>T EGFR ENST00000275493.6 3633 3236 1136567 1136567 1049131 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18640945 surgery - NOS NS 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875344 1875344 1765927 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1921943 1921943 1809261 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264345 2264345 2131329 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1162973 1162973 1075296 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18992959 NS primary 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278196 1278196 1189494 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1967524 1967524 1854016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23807543 fixed - NOS metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1499486 1499486 1422364 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21440951 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664345 2664345 2524415 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed primary 50 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2151464 2151464 2020492 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24742923 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862078 2862078 2717283 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 32122695 circulating tumour metastasis 62 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879524 1879524 1770026 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1479081 1479081 1402774 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2069207 2069207 1948782 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24346091 NS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777354 1777354 1681357 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1877566 1877566 1768127 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23408463 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1606263 1606263 1525577 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22132735 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638765 1638765 1554764 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1443062 1443062 1367347 lung left_upper_lobe NS NS carcinoma small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20837450 surgery - NOS metastasis 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891190 1891190 1780559 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1174291 1174291 1086310 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 920156 920156 837236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 51 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891209 1891209 1780578 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1921945 1921945 1809263 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2644122 2644122 2504409 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264428 2264428 2131412 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264428 2264428 2131412 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549155 2549155 2410610 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1857887 1857887 1750377 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM34167 178379046 c.? p.G598V Substitution - Missense + - Reported in another cancer sample as somatic 23243055 surgery-fixed recurrent ENSP00000275493.2:p.Gly598Val EGFR ENST00000275493.6 3633 3236 2421167 2421167 2284089 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 924350 924350 841125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51804843 COSM12429 99380902 c.2573_2574delinsGT p.L858R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573_2574delinsGT 7:g.55191822_55191823delinsGT EGFR ENST00000275493.6 3633 3236 1475399 1475399 1399098 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1549824 1549824 1471929 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 85 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618059 1618059 1536855 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990909 1990909 1876244 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860428 1860428 1751369 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897808 897808 815430 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625550 2625550 2485962 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618647 1618647 1537399 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 81 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2562098 2562098 2423494 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535050 1535050 1457385 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875345 1875345 1765928 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983833 1983833 1870069 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897836 897836 815458 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895120 1895120 1783812 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1094000 1094000 1008702 urinary_tract bladder NS NS carcinoma NS NS NS n COSV51833678 COSM26034 132594769 c.2489A>G p.K830R Substitution - Missense 38 7:55191873-55191873 + - PATHOGENIC .98545 Variant of unknown origin 17707060 surgery fresh/frozen NS ENSP00000395243.3:p.Lys830Arg ENST00000454757.6:c.2489A>G 7:g.55191873A>G EGFR ENST00000275493.6 3633 3236 1891189 1891189 1780558 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891208 1891208 1780577 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1310478 1310478 1221423 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602803 1602803 1522139 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136879 1136879 1049443 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895106 1895106 1783798 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983820 1983820 1870056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453433 1453433 1377466 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1098871 1098871 1013463 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924509 924509 841282 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1310469 1310469 1221414 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1067066 1067066 983046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1429326 1429326 1338777 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983732 1983732 1869968 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1231327 1231327 1143117 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1994213 1994213 1879468 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23897956 surgery - NOS metastasis 56 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1751715 1751715 1656531 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302245 1302245 1213296 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS 39 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920161 920161 837241 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1188174 1188174 1100073 thyroid NS NS NS carcinoma papillary_carcinoma follicular_variant NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19253367 surgery-fixed primary 76 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LC2/Ad 946052 862578 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1838659 1838659 1732760 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879486 1879486 1769988 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778593 2778593 2636647 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51771443 COSM12727 132551202 c.2416G>A p.V806I Substitution - Missense 38 7:55191800-55191800 + - PATHOGENIC .98898 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000395243.3:p.Val806Ile ENST00000454757.6:c.2416G>A 7:g.55191800G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2860650 2860650 2715938 central_nervous_system choroid_plexus NS NS other choroid_plexus_papilloma NS NS n COSV51771443 COSM12727 132551202 c.2416G>A p.V806I Substitution - Missense 38 7:55191800-55191800 + - PATHOGENIC .98898 Variant of unknown origin 31612017 surgery-fixed NS 3 ENSP00000395243.3:p.Val806Ile ENST00000454757.6:c.2416G>A 7:g.55191800G>A EGFR ENST00000275493.6 3633 3236 1471792 1471792 1395530 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51779794 COSM53264 99387824 c.2174C>T p.T725M Substitution - Missense 38 7:55174033-55174033 + - PATHOGENIC .97744 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000275493.2:p.Thr725Met ENST00000275493.6:c.2174C>T 7:g.55174033C>T EGFR ENST00000275493.6 3633 3236 1098868 1098868 1013460 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1795774 1795774 1697522 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23110940 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2151453 2151453 2020487 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24742923 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1107781 1107781 1021684 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451769 1451769 1375818 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20615575 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525665 2525665 2387857 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096247 2096247 1974311 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1637151 1637151 1553199 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2864415 2864415 2719571 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26199566 surgery-fixed NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076976 2076976 1955725 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed recurrent 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618881 1618881 1537633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 68 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862862 2862862 2718024 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29489023 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2697836 2697836 2556740 breast NS NS NS carcinoma NS NS NS n COSV51788004 COSM6906202 99436637 c.3190A>G p.S1064G Substitution - Missense 38 7:55202544-55202544 + - PATHOGENIC .8902 Variant of unknown origin 29349598 NS NS ENSP00000275493.2:p.Ser1064Gly ENST00000275493.6:c.3190A>G 7:g.55202544A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 18 2570181 2431478 skin face NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51818444 COSM5991528 132582202 c.2180C>T p.P727L Substitution - Missense 38 7:55181324-55181324 + - PATHOGENIC .97247 Variant of unknown origin 27311873 surgery-fixed NS 53 ENSP00000395243.3:p.Pro727Leu ENST00000454757.6:c.2180C>T 7:g.55181324C>T EGFR ENST00000275493.6 3633 3236 SK-MEL-28 1092633 1007455 skin NS NS NS malignant_melanoma NS NS NS n COSV51778029 COSM6268 99381060 c.2257C>T p.P753S Substitution - Missense hom 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 18006781 cell-line NS ENSP00000275493.2:p.Pro753Ser ENST00000275493.6:c.2257C>T 7:g.55174794C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302291 1302291 1213342 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990904 1990904 1876239 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1047909 1047909 964138 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17335935 pleural effusion primary 83 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239189 2239189 2106721 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 25134330 surgery - NOS NS 81 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1517361 1517361 1439745 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51807109 COSM88729 132564896 c.2023T>C p.S675P Substitution - Missense 38 7:55174017-55174017 + - PATHOGENIC .97572 Variant of unknown origin 21610522 NS primary 68 ENSP00000395243.3:p.Ser675Pro ENST00000454757.6:c.2023T>C 7:g.55174017T>C EGFR ENST00000275493.6 3633 3236 1469398 1469398 1393137 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734083 1734083 1640032 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22842370 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1499487 1499487 1422365 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21440951 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1223074 1223074 1134906 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 19473722 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862111 2862111 2717313 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51788393 COSM13979 133219516 c.2035G>A p.G679S Substitution - Missense 38 7:55174029-55174029 + - PATHOGENIC .98273 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000415559.1:p.Gly679Ser ENST00000455089.5:c.2035G>A 7:g.55174029G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 V197 1179751 1091713 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897799 897799 815421 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2772830 2772830 2631012 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 29594878 surgery - NOS recurrent 89 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2664362 2664362 2524424 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 36 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2241835 2241835 2109366 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25228365 NS primary ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879532 1879532 1770034 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239184 2239184 2106716 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765947 COSM4302133 132565127 c.1942A>G p.T648A Substitution - Missense 38 7:55173936-55173936 + - PATHOGENIC .98314 Variant of unknown origin 25130612 surgery - NOS NS 66 ENSP00000395243.3:p.Thr648Ala ENST00000454757.6:c.1942A>G 7:g.55173936A>G EGFR ENST00000275493.6 3633 3236 1610411 1610411 1529651 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22142557 pleural effusion NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1489664 1489664 1412822 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21155184 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777308 1777308 1681311 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535056 1535056 1457391 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081814 2081814 1960236 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481317 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1631948 1631948 1548818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2626119 2626119 2486531 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51779794 COSM53264 133215961 c.2039C>T p.T680M Substitution - Missense 38 7:55174033-55174033 + - PATHOGENIC .97744 Reported in another cancer sample as somatic 26645239 surgery-fixed NS ENSP00000415559.1:p.Thr680Met ENST00000455089.5:c.2039C>T 7:g.55174033C>T EGFR ENST00000275493.6 3633 3236 1884042 1884042 1773931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23495083 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522948 1522948 1445320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 64 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2422786 2422786 2285708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2064709 2064709 1944786 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1113000 1113000 1026509 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51780009 COSM27042 132564997 c.2147A>G p.D716G Substitution - Missense 38 7:55174819-55174819 + - PATHOGENIC .9946 Variant of unknown origin 18302229 surgery - NOS NS 68 ENSP00000395243.3:p.Asp716Gly ENST00000454757.6:c.2147A>G 7:g.55174819A>G EGFR ENST00000275493.6 3633 3236 1777298 1777298 1681301 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996948 1996948 1882157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 71 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1996948 1996948 1882157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 71 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1879492 1879492 1769994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2000262 2000262 1885160 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921880 1921880 1809198 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842974 1842974 1736222 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163059 2163059 2031643 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965824 1965824 1852317 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 22 1433987 1343402 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 79 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077340 1077340 992594 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891235 1891235 1780604 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875381 1875381 1765964 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345542 2345542 2210214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336831 1336831 1247216 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027797 2027797 1909700 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110470 1110470 1024348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1038993 1038993 955570 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879564 1879564 1770066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1135423 1135423 1047987 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1168010 1168010 1080252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1113265 1113265 1026764 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18449007 surgery-fixed NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881916 1881916 1772067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 54 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2096120 2096120 1974184 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345553 2345553 2210225 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860418 1860418 1751359 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983822 1983822 1870058 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469822 1469822 1393561 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2214528 2214528 2082652 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1594603 1594603 1515571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1120942 1120942 1034098 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965912 1965912 1852405 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2661745 2661745 2521883 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28891180 circulating tumour NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618791 1618791 1537543 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22215752 surgery-fixed NS 83 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618791 1618791 1537543 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 83 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1592880 1592880 1513806 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 1592880 1592880 1513806 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1734175 1734175 1640124 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22843912 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2824229 2824229 2680047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 31542322 surgery - NOS recurrent 52 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1522948 1522948 1445320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 64 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226914 2226914 2094649 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777782 COSM6227 133210005 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.His790Leu ENST00000455089.5:c.2369A>T 7:g.55191753A>T EGFR ENST00000275493.6 3633 3236 BC1-4 2824186 2680012 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51787208 COSM327142 99376659 c.3352G>A p.A1118T Substitution - Missense 38 7:55205336-55205336 + - NEUTRAL .10522 Reported in another cancer sample as somatic 31867841 circulating tumour recurrent 54 ENSP00000275493.2:p.Ala1118Thr ENST00000275493.6:c.3352G>A 7:g.55205336G>A EGFR ENST00000275493.6 3633 3236 1513032 1513032 1435711 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM30754 178378833 c.? p.L747P Substitution - Missense + - Reported in another cancer sample as somatic 21502435 surgery - NOS NS ENSP00000275493.2:p.Leu747Pro EGFR ENST00000275493.6 3633 3236 1435666 1435666 1344945 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 20661086 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-91-6847-01 1914094 1802376 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 62 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077372 1077372 992626 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1842671 1842671 1735931 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23275780 surgery - NOS primary 48 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990914 1990914 1876249 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2432441 2432441 2295342 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25798276 NS NS 85 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-103-tumor 2819029 2675328 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732919 2732919 2591672 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 133206822 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 73 ENSP00000415559.1:p.Thr218Pro ENST00000455089.5:c.652A>C 7:g.55154050A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879533 1879533 1770035 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194729 1194729 1106624 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1319151 1319151 1230050 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20146086 surgery - NOS recurrent 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1319151 1319151 1230050 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 20146086 surgery - NOS recurrent 54 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064703 2064703 1944780 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 946824 946824 863347 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1515268 1515268 1437878 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1996939 1996939 1882148 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM24429 178380423 c.? p.E709G Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 55 ENSP00000275493.2:p.Glu709Gly EGFR ENST00000275493.6 3633 3236 1996939 1996939 1882148 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551475 1551475 1473580 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214559 2214559 2082683 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665715 2665715 2525424 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS primary 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885186 1885186 1775073 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965837 1965837 1852330 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096098 2096098 1974162 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549158 2549158 2410613 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1456556 1456556 1380531 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-49-4494-01 1780138 1684137 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 77 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-49-4494-01 1780138 1684137 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 77 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166417 1166417 1078731 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51815916 COSM28600 132564415 c.1960C>T p.P654S Substitution - Missense het 38 7:55173954-55173954 + - PATHOGENIC .97389 Variant of unknown origin 16870303 surgery - NOS NS 75 ENSP00000395243.3:p.Pro654Ser ENST00000454757.6:c.1960C>T 7:g.55173954C>T EGFR ENST00000275493.6 3633 3236 2809833 2809833 2666500 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31315676 cerebrospinal fluid recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1512588 1512588 1435272 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21508367 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-55-7573-01 1914019 1802301 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51830809 COSM85993 133240844 c.2125A>G p.K709E Substitution - Missense 38 7:55174797-55174797 + - PATHOGENIC .99211 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 72 ENSP00000415559.1:p.Lys709Glu ENST00000455089.5:c.2125A>G 7:g.55174797A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1443062 1443062 1367347 lung left_upper_lobe NS NS carcinoma small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20837450 surgery - NOS metastasis 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1512591 1512591 1435275 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21508367 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618063 1618063 1536859 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996937 1996937 1882146 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996937 1996937 1882146 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 54 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1627938 1627938 1544844 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21945923 fine needle aspirate NS 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879488 1879488 1769990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891190 1891190 1780559 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920156 920156 837236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 51 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1981026 1981026 1867262 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895155 1895155 1783847 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2067301 2067301 1947098 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23783797 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879486 1879486 1769988 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2026223 2026223 1908312 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51817197 COSM1716258 132594144 c.2468A>T p.E823V Substitution - Missense het 38 7:55191852-55191852 + - PATHOGENIC .96496 Variant of unknown origin 24040454 surgery-fixed NS ENSP00000395243.3:p.Glu823Val ENST00000454757.6:c.2468A>T 7:g.55191852A>T EGFR ENST00000275493.6 3633 3236 1856196 1856196 1748749 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240672 2240672 2108203 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 48 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345062 2345062 2209734 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983730 1983730 1869966 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1549824 1549824 1471929 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 85 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875344 1875344 1765927 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2426831 2426831 2289752 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2426831 2426831 2289752 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM5010368 178378709 c.? p.C797S Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Cys797Ser EGFR ENST00000275493.6 3633 3236 2025408 2025408 1907497 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1107244 1107244 1021156 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924512 924512 841285 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 924512 924512 841285 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1879570 1879570 1770072 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2345490 2345490 2210162 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067064 1067064 983044 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875345 1875345 1765928 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PGBM27 1630925 1547795 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51858275 COSM506581 132603804 c.2815G>A p.D939N Substitution - Missense 38 7:55201191-55201191 + - PATHOGENIC .99577 Variant of unknown origin 22286061 surgery - NOS NS 9 ENSP00000395243.3:p.Asp939Asn ENST00000454757.6:c.2815G>A 7:g.55201191G>A EGFR ENST00000275493.6 3633 3236 1885171 1885171 1775058 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2009161 2009161 1891895 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1966315 1966315 1852808 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1715981 1715981 1623543 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22760226 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637267 1637267 1553315 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1551549 1551549 1473654 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862241 2862241 2717431 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25969368 surgery-fixed primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1734967 1734967 1640911 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479952 1479952 1403612 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2625579 2625579 2485991 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 74 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471792 1471792 1395530 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51779794 COSM53264 133215961 c.2039C>T p.T680M Substitution - Missense 38 7:55174033-55174033 + - PATHOGENIC .97744 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000415559.1:p.Thr680Met ENST00000455089.5:c.2039C>T 7:g.55174033C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098868 1098868 1013460 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-B0-5713-01 1779868 1683867 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51801505 COSM485464 132615881 c.2279A>G p.H760R Substitution - Missense hom 38 7:55181423-55181423 + - PATHOGENIC .97392 Variant of unknown origin 416 fresh/frozen - NOS primary 75 ENSP00000395243.3:p.His760Arg ENST00000454757.6:c.2279A>G 7:g.55181423A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-18-X05124 2905679 2759935 NS NS NS NS malignant_melanoma NS NS NS n COSV105863708 COSM10000062 132548221 c.2606C>T p.P869L Substitution - Missense 38 7:55198756-55198756 + - PATHOGENIC .98269 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Pro869Leu ENST00000454757.6:c.2606C>T 7:g.55198756C>T EGFR ENST00000275493.6 3633 3236 2046604 2046604 1926899 lung NS NS NS carcinoma mixed_small_cell_carcinoma-adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24195468 surgery - NOS primary 70 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1029018 1029018 945889 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17075123 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1696870 1696870 1604998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22674612 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874749 1874749 1765340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469506 1469506 1393245 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SK-MEL-28 1092633 1007455 skin NS NS NS malignant_melanoma NS NS NS n COSV51778029 COSM6268 133209348 c.2122C>T p.P708S Substitution - Missense hom 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 18006781 cell-line NS ENSP00000415559.1:p.Pro708Ser ENST00000455089.5:c.2122C>T 7:g.55174794C>T EGFR ENST00000275493.6 3633 3236 1996916 1996916 1882125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 54 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1637125 1637125 1553173 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336838 1336838 1247223 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631948 1631948 1548818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777383 1777383 1681386 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246712 1246712 1158391 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141318 1141318 1053766 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1963280 1963280 1849828 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23599349 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 5326 915962 833361 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51823220 COSM13179 99386001 c.2080C>T p.P694S Substitution - Missense 38 7:55173939-55173939 + - PATHOGENIC .97389 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000275493.2:p.Pro694Ser ENST00000275493.6:c.2080C>T 7:g.55173939C>T EGFR ENST00000275493.6 3633 3236 2027344 2027344 1909412 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 40 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2027344 2027344 1909412 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 40 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862101 2862101 2717303 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51805944 COSM28931 132608179 c.2398G>A p.V800M Substitution - Missense 38 7:55191782-55191782 + - PATHOGENIC .98912 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000395243.3:p.Val800Met ENST00000454757.6:c.2398G>A 7:g.55191782G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1179043 1179043 1091005 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51813062 COSM12764 132548042 c.2434G>A p.G812R Substitution - Missense het 38 7:55191818-55191818 + - PATHOGENIC .98898 Variant of unknown origin 19190079 surgery-fixed primary 52 ENSP00000395243.3:p.Gly812Arg ENST00000454757.6:c.2434G>A 7:g.55191818G>A EGFR ENST00000275493.6 3633 3236 2264334 2264334 2131318 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2344940 2344940 2209612 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25674250 NS NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1036707 1036707 953464 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17106442 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891276 1891276 1780645 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064709 2064709 1944786 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924350 924350 841125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51804843 COSM12429 133209145 c.2438_2439delinsGT p.L813R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438_2439delinsGT 7:g.55191822_55191823delinsGT EGFR ENST00000275493.6 3633 3236 1637076 1637076 1553124 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 MG-160-tumor 2819059 2675358 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1887440 1887440 1777112 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879492 1879492 1769994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2680657 2680657 2539930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 60 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2667811 2667811 2527473 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM34167 178379046 c.? p.G598V Substitution - Missense + - Reported in another cancer sample as somatic 28663030 surgery-fixed primary ENSP00000275493.2:p.Gly598Val EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1135423 1135423 1047987 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1168010 1168010 1080252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-22-4601-01 1780882 1684881 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51789475 COSM747423 132586620 c.2921C>T p.P974L Substitution - Missense 38 7:55201297-55201297 + - PATHOGENIC .99234 Variant of unknown origin 418 fresh/frozen - NOS primary 73 ENSP00000395243.3:p.Pro974Leu ENST00000454757.6:c.2921C>T 7:g.55201297C>T EGFR ENST00000275493.6 3633 3236 2476896 2476896 2339665 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-06-0127-01 1910170 1798461 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766389 COSM43067 99404429 c.874G>T p.V292L Substitution - Missense het 38 7:55154137-55154137 + - PATHOGENIC .98997 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 67 ENSP00000275493.2:p.Val292Leu ENST00000275493.6:c.874G>T 7:g.55154137G>T EGFR ENST00000275493.6 3633 3236 1522885 1522885 1445257 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924512 924512 841285 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924512 924512 841285 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879570 1879570 1770072 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592880 1592880 1513806 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592880 1592880 1513806 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594603 1594603 1515571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1336419 1336419 1246804 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20430469 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1029247 1029247 946118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16921488 pleural effusion NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2822956 2822956 2678815 lung right_upper_lobe NS NS carcinoma hepatoid_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 31558230 surgery - NOS recurrent 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1098859 1098859 1013451 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2730696 2730696 2589468 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 99377339 c.2239_2240delinsCC p.L747P Substitution - Missense 38 7:55174776-55174777 + Yes Reported in another cancer sample as somatic 29673089 surgery-fixed primary 54 ENSP00000275493.2:p.Leu747Pro ENST00000275493.6:c.2239_2240delinsCC 7:g.55174776_55174777delinsCC EGFR ENST00000275493.6 3633 3236 1876986 1876986 1767548 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096046 2096046 1974110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1705345 1705345 1613329 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51769837 COSM249780 132559442 c.2275G>A p.E759K Substitution - Missense 38 7:55181419-55181419 + - PATHOGENIC .97109 Variant of unknown origin 22722798 surgery - NOS recurrent 71 ENSP00000395243.3:p.Glu759Lys ENST00000454757.6:c.2275G>A 7:g.55181419G>A EGFR ENST00000275493.6 3633 3236 1052978 1052978 969049 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17410005 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 965389 965389 881673 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16382114 surgery-fixed NS 57 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1986226 1986226 1872462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1986226 1986226 1872462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2426842 2426842 2289763 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2437326 2437326 2300176 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23211219 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218537 2218537 2086548 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891249 1891249 1780618 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1523394 1523394 1445766 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21626329 surgery-fixed recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1201399 1201399 1113289 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19357847 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422829 2422829 2285751 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1028970 1028970 945841 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 17062680 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 MG-042-tumor 2818992 2675291 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2096181 2096181 1974245 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 946827 946827 863350 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895155 1895155 1783847 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879564 1879564 1770066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 NPC0001PT00331T00331 2857371 2712671 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2865563 2865563 2720693 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29120087 surgery-fixed primary 47 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1734967 1734967 1640911 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879488 1879488 1769990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2096219 2096219 1974283 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345065 2345065 2209737 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2131894 2131894 2005958 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419415 NS NS 75 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2096207 2096207 1974271 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1459529 1459529 1383472 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1445173 1445173 1369416 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 20682976 surgery - NOS metastasis 58 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009161 2009161 1891895 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592978 1592978 1513904 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51772282 COSM133202 132556800 c.2201G>A p.G734D Substitution - Missense 38 7:55181345-55181345 + - PATHOGENIC .98244 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000395243.3:p.Gly734Asp ENST00000454757.6:c.2201G>A 7:g.55181345G>A EGFR ENST00000275493.6 3633 3236 2425742 2425742 2288663 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345602 2345602 2210274 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1223073 1223073 1134905 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 19473722 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1334746 1334746 1245131 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20401612 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1099059 1099059 1013651 lung right_bronchus NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18192072 surgery-fixed NS 40 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1107244 1107244 1021156 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NKI_LPSCC_59 2810565 2667226 upper_aerodigestive_tract pharynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV99296441 COSM9178873 132577293 c.2908G>A p.E970K Substitution - Missense 38 7:55201284-55201284 + - PATHOGENIC .99529 Variant of unknown origin 29884412 surgery fresh/frozen primary ENSP00000395243.3:p.Glu970Lys ENST00000454757.6:c.2908G>A 7:g.55201284G>A EGFR ENST00000275493.6 3633 3236 2218523 2218523 2086534 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141322 1141322 1053770 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705485 1705485 1613391 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2015359 2015359 1897567 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23963360 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264085 2264085 2131069 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148606 2148606 2017736 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2644123 2644123 2504410 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891247 1891247 1780616 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2027787 2027787 1909690 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965639 1965639 1852132 lung left_lower_lobe NS NS carcinoma large_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23774386 surgery - NOS metastasis 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1965639 1965639 1852132 lung left_lower_lobe NS NS carcinoma large_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23774386 surgery - NOS metastasis 72 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1201379 1201379 1113269 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 19357847 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2069157 2069157 1948732 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24346091 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2245043 2245043 2112319 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638769 1638769 1554768 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1097610 1097610 1012271 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1230468 1230468 1142282 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1500143 1500143 1423022 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1031897 1031897 948688 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 17085664 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 6367 915989 833388 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51862232 COSM13195 132607182 c.2417T>C p.V806A Substitution - Missense 38 7:55191801-55191801 + - PATHOGENIC .97317 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000395243.3:p.Val806Ala ENST00000454757.6:c.2417T>C 7:g.55191801T>C EGFR ENST00000275493.6 3633 3236 2264173 2264173 2131157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1487185 1487185 1410795 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21317742 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000150 2000150 1885048 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345097 2345097 2209769 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1637266 1637266 1553314 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1532703 1532703 1455063 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 20925915 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1165597 1165597 1077911 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 19050706 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1914969 1914969 1802971 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-160-tumor 2819059 2675358 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0127-01 1910170 1798461 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766389 COSM43067 133230198 c.739G>T p.V247L Substitution - Missense het 38 7:55154137-55154137 + - PATHOGENIC .98997 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 67 ENSP00000415559.1:p.Val247Leu ENST00000455089.5:c.739G>T 7:g.55154137G>T EGFR ENST00000275493.6 3633 3236 2732886 2732886 2591639 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779091 COSM2155593 99388542 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 50 ENSP00000275493.2:p.Thr363Ile ENST00000275493.6:c.1088C>T 7:g.55156614C>T EGFR ENST00000275493.6 3633 3236 1166429 1166429 1078743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773206 COSM28603 99389206 c.2293G>A p.V765M Substitution - Missense hom 38 7:55181302-55181302 + - PATHOGENIC .97963 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 70 ENSP00000275493.2:p.Val765Met ENST00000275493.6:c.2293G>A 7:g.55181302G>A EGFR ENST00000275493.6 3633 3236 1734166 1734166 1640115 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22843912 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000060 2000060 1884958 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000060 2000060 1884958 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS 59 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1895125 1895125 1783817 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879538 1879538 1770040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891276 1891276 1780645 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2029020 2029020 1910902 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2096033 2096033 1974097 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 CT75 1063219 979264 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 65 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469386 1469386 1393125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637253 1637253 1553301 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1855993 1855993 1748546 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174306 1174306 1086325 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 946826 946826 863349 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 NSCLC-20 1325814 1236310 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 20207772 surgery-fixed NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770573 1770573 1674813 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148608 2148608 2017738 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098859 1098859 1013451 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2730696 2730696 2589468 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 133205309 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + Yes Reported in another cancer sample as somatic 29673089 surgery-fixed primary 54 ENSP00000415559.1:p.Leu702Pro ENST00000455089.5:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1876986 1876986 1767548 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5326 915962 833361 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51823220 COSM13179 133214404 c.1945C>T p.P649S Substitution - Missense 38 7:55173939-55173939 + - PATHOGENIC .97389 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000415559.1:p.Pro649Ser ENST00000455089.5:c.1945C>T 7:g.55173939C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2027344 2027344 1909412 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 40 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2027344 2027344 1909412 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 40 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1966334 1966334 1852827 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1770619 1770619 1674859 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1098877 1098877 1013469 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1202166 1202166 1114052 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19371962 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1484304 1484304 1407930 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51773392 COSM20892 99431457 c.2411A>G p.E804G Substitution - Missense 38 7:55181420-55181420 + - PATHOGENIC .9793 Reported in another cancer sample as somatic 21266046 surgery-fixed primary 68 ENSP00000275493.2:p.Glu804Gly ENST00000275493.6:c.2411A>G 7:g.55181420A>G EGFR ENST00000275493.6 3633 3236 2076198 2076198 1955011 lung right_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 24396447 bronchoalveolar lavage fluid NS 73 ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 1444768 1444768 1369011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345361 2345361 2210033 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1594591 1594591 1515559 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51837705 COSM29577 99392755 c.2563G>A p.D855N Substitution - Missense 38 7:55191812-55191812 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000275493.2:p.Asp855Asn ENST00000275493.6:c.2563G>A 7:g.55191812G>A EGFR ENST00000275493.6 3633 3236 2095975 2095975 1974039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-042-tumor 2818992 2675291 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 965389 965389 881673 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16382114 surgery-fixed NS 57 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891247 1891247 1780616 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1965639 1965639 1852132 lung left_lower_lobe NS NS carcinoma large_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23774386 surgery - NOS metastasis 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2000248 2000248 1885146 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345559 2345559 2210231 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148631 2148631 2017761 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2148631 2148631 2017761 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1668658 1668658 1581950 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22523351 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2479687 2479687 2342434 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26923333 NS NS 43 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1566429 1566429 1488236 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21242665 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914945 1914945 1802947 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 946827 946827 863350 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00331T00331 2857371 2712671 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659761 2659761 2519919 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51802260 COSM6506511 132595121 c.1997A>G p.E666G Substitution - Missense 38 7:55173991-55173991 + - PATHOGENIC .97458 Variant of unknown origin 28744312 surgery-fixed NS ENSP00000395243.3:p.Glu666Gly ENST00000454757.6:c.1997A>G 7:g.55173991A>G EGFR ENST00000275493.6 3633 3236 1637071 1637071 1553119 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1530970 1530970 1453342 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KYSE-450 1339910 1250286 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 20443891 cell-line NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DM17 2466858 2329689 skin arm NS NS malignant_melanoma desmoplastic NS NS n COSV51804378 COSM5608346 132596141 c.1423C>T p.P475S Substitution - Missense 38 7:55161558-55161558 + - PATHOGENIC .7492 Variant of unknown origin 26343386 surgery-fixed NS 74 ENSP00000395243.3:p.Pro475Ser ENST00000454757.6:c.1423C>T 7:g.55161558C>T EGFR ENST00000275493.6 3633 3236 MG-104-tumor 2819030 2675329 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1998651 1998651 1883723 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 99378740 c.2582T>G p.L861R Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .98181 Reported in another cancer sample as somatic 23945392 surgery - NOS primary 62 ENSP00000275493.2:p.Leu861Arg ENST00000275493.6:c.2582T>G 7:g.55191831T>G EGFR ENST00000275493.6 3633 3236 1998651 1998651 1883723 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51779524 COSM18425 99379336 c.2156G>A p.G719D Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .97987 Reported in another cancer sample as somatic 23945392 surgery - NOS primary 62 ENSP00000275493.2:p.Gly719Asp ENST00000275493.6:c.2156G>A 7:g.55174015G>A EGFR ENST00000275493.6 3633 3236 1107779 1107779 1021682 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891213 1891213 1780582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345489 2345489 2210161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525708 2525708 2387896 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 fine needle aspirate metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2153075 2153075 2022085 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891249 1891249 1780618 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2141448 2141448 2010666 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24636848 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2141443 2141443 2010661 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24636848 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096289 2096289 1974353 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027750 2027750 1909653 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746669 1746669 1651645 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 74 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1535057 1535057 1457392 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2862406 2862406 2717592 lung right_lower_lobe NS NS carcinoma adenocarcinoma transformed_to_sarcomatoid_carcinoma NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 31561203 surgery - NOS metastasis 76 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469802 1469802 1393541 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264431 2264431 2131415 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2046045 2046045 1926340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096144 2096144 1974208 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895125 1895125 1783817 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879538 1879538 1770040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2345792 2345792 2210464 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1706996 1706996 1614902 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22722787 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2579570 2579570 2440907 NS NS NS NS malignant_melanoma NS NS NS n COSV51787507 COSM13188 99385457 c.2281G>A p.D761N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000275493.2:p.Asp761Asn ENST00000275493.6:c.2281G>A 7:g.55174818G>A EGFR ENST00000275493.6 3633 3236 1842983 1842983 1736231 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096001 2096001 1974065 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2757342 2757342 2615979 lung right NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28274743 surgery - NOS recurrent 41 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2757342 2757342 2615979 lung right NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28274743 surgery - NOS recurrent 41 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770713 1770713 1674953 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444769 1444769 1369012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986158 1986158 1872394 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1965639 1965639 1852132 lung left_lower_lobe NS NS carcinoma large_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23774386 surgery - NOS metastasis 72 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659760 2659760 2519918 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51771654 COSM6506512 132563027 c.2005A>G p.K669E Substitution - Missense 38 7:55173999-55173999 + - PATHOGENIC .9657 Variant of unknown origin 28744312 surgery-fixed NS ENSP00000395243.3:p.Lys669Glu ENST00000454757.6:c.2005A>G 7:g.55173999A>G EGFR ENST00000275493.6 3633 3236 2214574 2214574 2082698 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1587279 1587279 1508450 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148005 2148005 2017147 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24707260 surgery - NOS primary 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1231321 1231321 1143111 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2422933 2422933 2285855 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096306 2096306 1974370 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1931648 1931648 1818938 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1875688 1875688 1766271 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000221 2000221 1885119 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 BC1-2 2824184 2680011 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51787208 COSM327142 99376659 c.3352G>A p.A1118T Substitution - Missense 38 7:55205336-55205336 + - NEUTRAL .10522 Reported in another cancer sample as somatic 31867841 circulating tumour recurrent 54 ENSP00000275493.2:p.Ala1118Thr ENST00000275493.6:c.3352G>A 7:g.55205336G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 946826 946826 863349 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098877 1098877 1013469 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166429 1166429 1078743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773206 COSM28603 133217070 c.2158G>A p.V720M Substitution - Missense hom 38 7:55181302-55181302 + - PATHOGENIC .97963 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 70 ENSP00000415559.1:p.Val720Met ENST00000455089.5:c.2158G>A 7:g.55181302G>A EGFR ENST00000275493.6 3633 3236 1122184 1122184 1035228 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18418018 surgery - NOS NS 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618761 1618761 1537513 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22215752 surgery-fixed NS 48 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618761 1618761 1537513 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 48 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226162 2226162 2093897 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 V17 1179742 1091704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 50 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2078479 2078479 1957198 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2644116 2644116 2504403 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1135425 1135425 1047989 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1729972 1729972 1635943 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937548 1937548 1824482 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594591 1594591 1515559 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51837705 COSM29577 133220093 c.2428G>A p.D810N Substitution - Missense 38 7:55191812-55191812 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000415559.1:p.Asp810Asn ENST00000455089.5:c.2428G>A 7:g.55191812G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CT75 1063219 979264 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 65 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1484304 1484304 1407930 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51773392 COSM20892 133254998 c.2276A>G p.E759G Substitution - Missense 38 7:55181420-55181420 + - PATHOGENIC .9793 Reported in another cancer sample as somatic 21266046 surgery-fixed primary 68 ENSP00000415559.1:p.Glu759Gly ENST00000455089.5:c.2276A>G 7:g.55181420A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2076198 2076198 1955011 lung right_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 24396447 bronchoalveolar lavage fluid NS 73 ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 TCGA-55-7573-01 1914019 1802301 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51830809 COSM85993 99415063 c.2260A>G p.K754E Substitution - Missense 38 7:55174797-55174797 + - PATHOGENIC .99211 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 72 ENSP00000275493.2:p.Lys754Glu ENST00000275493.6:c.2260A>G 7:g.55174797A>G EGFR ENST00000275493.6 3633 3236 1676429 1676429 1589197 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1980074 1980074 1866317 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 59 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1154578 1154578 1066914 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 18946755 surgery fresh/frozen NS ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 1618637 1618637 1537389 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 87 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1965925 1965925 1852418 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1965925 1965925 1852418 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345110 2345110 2209782 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2218538 2218538 2086549 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1-87 946049 862575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618803 1618803 1537555 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 80 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618803 1618803 1537555 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 80 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2625594 2625594 2486006 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 52 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2345078 2345078 2209750 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2402488 2402488 2265344 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 68 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1879485 1879485 1769987 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1753612 1753612 1658411 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22926905 NS NS 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096249 2096249 1974313 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2345102 2345102 2209774 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1777363 1777363 1681366 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770751 1770751 1674991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-104-tumor 2819030 2675329 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1998651 1998651 1883723 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 133206840 c.2447T>G p.L816R Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .98181 Reported in another cancer sample as somatic 23945392 surgery - NOS primary 62 ENSP00000415559.1:p.Leu816Arg ENST00000455089.5:c.2447T>G 7:g.55191831T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1998651 1998651 1883723 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51779524 COSM18425 133207486 c.2021G>A p.G674D Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .97987 Reported in another cancer sample as somatic 23945392 surgery - NOS primary 62 ENSP00000415559.1:p.Gly674Asp ENST00000455089.5:c.2021G>A 7:g.55174015G>A EGFR ENST00000275493.6 3633 3236 983126 983126 898844 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965273 1965273 1851768 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23803047 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179649 1179649 1091611 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964308 1964308 1850843 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770548 1770548 1674788 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469357 1469357 1393096 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664337 2664337 2524411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed primary 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637239 1637239 1553287 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083116 2083116 1961537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24300726 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770521 1770521 1674761 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014076 1014076 931250 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120940 1120940 1034096 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2141448 2141448 2010666 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24636848 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046018 2046018 1926313 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2465698 2465698 2328529 lung left NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26746366 surgery - NOS primary 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493333 1493333 1416323 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106556 2106556 1984419 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345529 2345529 2210201 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290962 2290962 2157027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214529 2214529 2082653 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705474 1705474 1613380 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1931648 1931648 1818938 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891213 1891213 1780582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618719 1618719 1537471 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240664 2240664 2108195 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 89 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914943 1914943 1802945 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345465 2345465 2210137 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264198 2264198 2131182 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838697 1838697 1732798 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076954 2076954 1955703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24369725 surgery-fixed metastasis 54 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1638748 1638748 1554747 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264161 2264161 2131145 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965878 1965878 1852371 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965890 1965890 1852383 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1512592 1512592 1435276 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21508367 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469439 1469439 1393178 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777321 1777321 1681324 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081813 2081813 1960235 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481317 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469382 1469382 1393121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838720 1838720 1732821 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226147 2226147 2093882 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887424 1887424 1777096 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2579570 2579570 2440907 NS NS NS NS malignant_melanoma NS NS NS n COSV51787507 COSM13188 133213942 c.2146G>A p.D716N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000415559.1:p.Asp716Asn ENST00000455089.5:c.2146G>A 7:g.55174818G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668455 1668455 1581748 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51783814 COSM219793 132597555 c.2463G>T p.E821D Substitution - Missense 38 7:55191847-55191847 + - PATHOGENIC .94716 Variant of unknown origin 22523180 surgery - NOS NS ENSP00000395243.3:p.Glu821Asp ENST00000454757.6:c.2463G>T 7:g.55191847G>T EGFR ENST00000275493.6 3633 3236 2264147 2264147 2131131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887398 1887398 1777070 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1962802 1962802 1849350 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23769878 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1672455 1672455 1585509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21729655 surgery-fixed metastasis 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096024 2096024 1974088 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637177 1637177 1553225 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960169 1960169 1846809 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964320 1964320 1850855 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2750879 2750879 2609575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27086595 surgery-fixed NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096289 2096289 1974353 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937587 1937587 1824521 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148589 2148589 2017719 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965823 1965823 1852316 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1053130 1053130 969201 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17409961 surgery - NOS NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000165 2000165 1885063 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1213646 1213646 1125513 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18978556 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1148809 1148809 1061250 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18799919 surgery - NOS primary 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2559404 2559404 2420828 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24158231 surgery fresh/frozen NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986169 1986169 1872405 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120925 1120925 1034081 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777382 1777382 1681385 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887410 1887410 1777082 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964327 1964327 1850862 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862406 2862406 2717592 lung right_lower_lobe NS NS carcinoma adenocarcinoma transformed_to_sarcomatoid_carcinoma NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31561203 surgery - NOS metastasis 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838673 1838673 1732774 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264431 2264431 2131415 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1445181 1445181 1369424 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20682976 surgery - NOS primary 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346481 2346481 2211144 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777358 1777358 1681361 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1107775 1107775 1021678 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777395 1777395 1681398 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838704 1838704 1732805 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777381 1777381 1681384 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2426836 2426836 2289757 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625594 2625594 2486006 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 52 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231321 1231321 1143111 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 V17 1179742 1091704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 50 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1135425 1135425 1047989 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1676421 1676421 1589189 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937517 1937517 1824451 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027795 2027795 1909698 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1-87 946049 862575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1551478 1551478 1473583 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421232 2421232 2284154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618753 1618753 1537505 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 54 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618753 1618753 1537505 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535059 1535059 1457394 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105794 2105794 1983832 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1592882 1592882 1513808 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 1469810 1469810 1393549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1223894 1223894 1135726 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19517135 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469362 1469362 1393101 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895122 1895122 1783814 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2205957 2205957 2074190 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980074 1980074 1866317 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 59 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-144-tumor 2819049 2675348 meninges NS NS NS meningioma atypical NS NS n COSV104369075 COSM9267309 132570944 c.1681C>G p.L561V Substitution - Missense 38 7:55165373-55165373 + - PATHOGENIC .90295 Variant of unknown origin 28713588 surgery - NOS NS ENSP00000395243.3:p.Leu561Val ENST00000454757.6:c.1681C>G 7:g.55165373C>G EGFR ENST00000275493.6 3633 3236 GCT135 2490762 2353411 genital_tract extragonadal central_nervous_system NS germ_cell_tumour embryonal_carcinoma NS NS n COSV51769863 COSM1090888 99381430 c.2224G>A p.V742I Substitution - Missense 38 7:55174761-55174761 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 26956871 surgery fresh/frozen metastasis ENSP00000275493.2:p.Val742Ile ENST00000275493.6:c.2224G>A 7:g.55174761G>A EGFR ENST00000275493.6 3633 3236 1542145 1542145 1464448 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1715979 1715979 1623541 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22760226 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777237 1777237 1681240 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226871 2226871 2094606 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879509 1879509 1770011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1076410 1076410 991664 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17607119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-78-7155-01 1914061 1802343 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51802877 COSM6178050 133281426 c.2567G>T p.G856V Substitution - Missense 38 7:55198717-55198717 + - PATHOGENIC .9948 Variant of unknown origin 417 fresh/frozen - NOS primary 68 ENSP00000415559.1:p.Gly856Val ENST00000455089.5:c.2567G>T 7:g.55198717G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879485 1879485 1769987 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1751714 1751714 1656530 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1107785 1107785 1021688 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2245042 2245042 2112318 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103751 1103751 1018003 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875348 1875348 1765931 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1551551 1551551 1473656 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2349275 2349275 2213667 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25654374 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879520 1879520 1770022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2271429 2271429 2138059 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25257380 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1998748 1998748 1883820 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 23937608 surgery-fixed primary 83 ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 1434452 1434452 1343810 eye conjunctiva NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51768262 COSM26445 99377063 c.2300C>T p.A767V Substitution - Missense 38 7:55181309-55181309 + - PATHOGENIC .97799 Reported in another cancer sample as somatic 20498858 fixed - NOS NS ENSP00000275493.2:p.Ala767Val ENST00000275493.6:c.2300C>T 7:g.55181309C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592882 1592882 1513808 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 2595746 2595746 2456622 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1592884 1592884 1513810 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 MG-228-tumor 2819103 2675402 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1602818 1602818 1522154 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226871 2226871 2094606 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879509 1879509 1770011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914810 914810 832259 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372583 2372583 2235376 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983771 1983771 1870007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899314 899314 816926 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2616332 2616332 2476818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26118982 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1876993 1876993 1767555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983836 1983836 1870072 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593023 1593023 1513949 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1931644 1931644 1818934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983702 1983702 1869938 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914806 914806 832255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103632 1103632 1017884 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 55 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1202555 1202555 1114441 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983721 1983721 1869957 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1310476 1310476 1221421 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1625792 1625792 1543016 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110459 1110459 1024337 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1451209 1451209 1375352 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1549837 1549837 1471942 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983783 1983783 1870019 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1661391 1661391 1575006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51845318 COSM214350 132553232 c.2467G>A p.E823K Substitution - Missense het 38 7:55191851-55191851 + - PATHOGENIC .98896 Variant of unknown origin 22483783 surgery-fixed NS 49 ENSP00000395243.3:p.Glu823Lys ENST00000454757.6:c.2467G>A 7:g.55191851G>A EGFR ENST00000275493.6 3633 3236 2076952 2076952 1955701 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24369725 surgery-fixed recurrent 56 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2665676 2665676 2525385 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28978102 surgery - NOS recurrent 77 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2026253 2026253 1908342 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1445191 1445191 1369434 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20682976 surgery - NOS metastasis 52 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-205-tumor 2819087 2675386 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-228-tumor 2819103 2675402 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P13_20580_7_S4_R1_001 2823451 2679304 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51846371 COSM7338932 132591315 c.2783G>A p.R928Q Substitution - Missense 38 7:55200385-55200385 + - PATHOGENIC .99379 Variant of unknown origin 31854063 surgery fresh/frozen primary 61 ENSP00000395243.3:p.Arg928Gln ENST00000454757.6:c.2783G>A 7:g.55200385G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2841802 2841802 2697351 soft_tissue fibrous_tissue_and_uncertain_origin NS NS desmoid_tumour-fibromatosis NS NS NS n COSV104576751 COSM9414780 132579080 c.3052G>A p.D1018N Substitution - Missense 38 7:55202541-55202541 + - PATHOGENIC .93865 Variant of unknown origin 32099073 surgery-fixed NS ENSP00000395243.3:p.Asp1018Asn ENST00000454757.6:c.3052G>A 7:g.55202541G>A EGFR ENST00000275493.6 3633 3236 MG-076-tumor 2819012 2675311 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1513031 1513031 1435711 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM30754 178378833 c.? p.L747P Substitution - Missense + - Reported in another cancer sample as somatic 21502435 surgery - NOS NS ENSP00000275493.2:p.Leu747Pro EGFR ENST00000275493.6 3633 3236 2361983 2361983 2224926 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 25726043 NS NS 68 ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895122 1895122 1783814 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GCT135 2490762 2353411 genital_tract extragonadal central_nervous_system NS germ_cell_tumour embryonal_carcinoma NS NS n COSV51769863 COSM1090888 133209747 c.2089G>A p.V697I Substitution - Missense 38 7:55174761-55174761 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 26956871 surgery fresh/frozen metastasis ENSP00000415559.1:p.Val697Ile ENST00000455089.5:c.2089G>A 7:g.55174761G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879520 1879520 1770022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 21 2626696 2487087 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 27322425 surgery-fixed metastasis ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891306 1891306 1780675 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895065 1895065 1783757 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592884 1592884 1513810 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 KYSE-450 1339910 1250286 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 20443891 cell-line NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602818 1602818 1522154 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1507380 1507380 1430249 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51794784 COSM13182 133203905 c.2068G>A p.G690S Substitution - Missense hom 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 21487925 NS NS ENSP00000415559.1:p.Gly690Ser ENST00000455089.5:c.2068G>A 7:g.55174740G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1751714 1751714 1656530 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-076-tumor 2819012 2675311 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2603002 2603002 2463893 NS NS NS NS carcinoma adenocarcinoma of_unknown_primary NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 26182302 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1456553 1456553 1380528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770626 1770626 1674866 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430053 1430053 1339471 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 12 1077311 992565 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1094003 1094003 1008705 urinary_tract bladder NS NS carcinoma NS NS NS n COSV51769451 COSM26036 99439084 c.2606A>G p.Y869C Substitution - Missense 38 7:55191855-55191855 + - PATHOGENIC .986 Reported in another cancer sample as somatic 17707060 surgery fresh/frozen NS ENSP00000275493.2:p.Tyr869Cys ENST00000275493.6:c.2606A>G 7:g.55191855A>G EGFR ENST00000275493.6 3633 3236 2026246 2026246 1908335 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00389T00389 2857373 2712673 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 132574485 c.1027G>A p.D343N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000395243.3:p.Asp343Asn ENST00000454757.6:c.1027G>A 7:g.55156787G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1179043 1179043 1091005 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51818061 COSM28930 132548037 c.2219C>A p.T740N Substitution - Missense hom 38 7:55181363-55181363 + - PATHOGENIC .95016 Variant of unknown origin 19190079 surgery-fixed primary 52 ENSP00000395243.3:p.Thr740Asn ENST00000454757.6:c.2219C>A 7:g.55181363C>A EGFR ENST00000275493.6 3633 3236 983135 983135 898853 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542240 1542240 1464543 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21784628 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1590999 1590999 1512115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027824 2027824 1909727 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525681 2525681 2387870 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2402486 2402486 2265342 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 59 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264432 2264432 2131416 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1165597 1165597 1077911 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 19050706 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1103804 1103804 1018056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18271876 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453488 1453488 1377521 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618779 1618779 1537531 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011155 2011155 1893793 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345852 2345852 2210524 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2264313 2264313 2131297 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591061 1591061 1512177 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422916 2422916 2285838 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618782 1618782 1537534 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264352 2264352 2131336 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2823656 2823656 2679509 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31157314 surgery - NOS metastasis 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2788070 2788070 2645488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29308976 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937551 1937551 1824485 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1517363 1517363 1439747 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21610522 surgery fresh/frozen metastasis 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027813 2027813 1909716 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2291926 2291926 2157990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25120214 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1135550 1135550 1048114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18676761 NS NS 87 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279056 1279056 1190352 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed primary 44 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542355 1542355 1464658 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1434748 1434748 1344106 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20813423 surgery - NOS primary 80 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656129 1656129 1570786 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21311943 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096086 2096086 1974150 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008968 2008968 1891702 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23979198 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264120 2264120 2131104 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046016 2046016 1926311 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011164 2011164 1893802 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937542 1937542 1824476 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2486049 2486049 2348698 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27013585 surgery - NOS primary 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770586 1770586 1674826 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618879 1618879 1537631 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921938 1921938 1809256 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2225973 2225973 2093708 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587268 1587268 1508439 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1835510 1835510 1730542 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23242440 NS NS 49 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345590 2345590 2210262 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777306 1777306 1681309 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264082 2264082 2131066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1467302 1467302 1391148 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20940188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1435659 1435659 1344938 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20661086 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921947 1921947 1809265 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179604 1179604 1091566 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770524 1770524 1674764 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011169 2011169 1893807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2136665 2136665 2006216 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345567 2345567 2210239 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1530970 1530970 1453342 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264432 2264432 2131416 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083097 2083097 1961518 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24300726 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515252 1515252 1437862 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2151451 2151451 2020487 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24742923 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076970 2076970 1955719 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed metastasis 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734174 1734174 1640123 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22843912 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264330 2264330 2131314 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474455 2474455 2337224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2864417 2864417 2719573 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26199566 surgery-fixed NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638770 1638770 1554769 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1541362 1541362 1463676 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21768463 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000171 2000171 1885069 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264201 2264201 2131185 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2439551 2439551 2302391 lung NS NS NS carcinoma invasive_mucinous_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24119562 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046014 2046014 1926309 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960179 1960179 1846819 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1862569 1862569 1753460 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23352033 fine needle aspirate primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014114 1014114 931288 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451758 1451758 1375807 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20615575 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885176 1885176 1775063 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329248 1329248 1239733 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1823853 1823853 1722247 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23212424 surgery-fixed primary 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2839890 2839890 2695656 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28961830 circulating tumour NS 36 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226163 2226163 2093898 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2823655 2823655 2679508 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31157314 surgery - NOS NS 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2865683 2865683 2720759 lung right_middle_lobe NS NS carcinoma enteric_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26139021 surgery - NOS primary 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096005 2096005 1974069 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246627 1246627 1158306 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1624152 1624152 1541739 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22000696 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2032070 2032070 1913541 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24103528 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214546 2214546 2082670 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444713 1444713 1368956 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637109 1637109 1553157 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777297 1777297 1681300 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479091 1479091 1402784 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 999912 999912 917135 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16785471 surgery - NOS primary 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1993863 1993863 1879119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23892415 surgery-fixed metastasis 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1837424 1837424 1731623 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1166938 178380056 c.? p.H773L Substitution - Missense + - Variant of unknown origin 23242437 NS NS ENSP00000275493.2:p.His773Leu EGFR ENST00000275493.6 3633 3236 1445188 1445188 1369431 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 20682976 surgery - NOS primary 76 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264263 2264263 2131247 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542298 1542298 1464601 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 899309 899309 816921 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469507 1469507 1393246 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2260330 2260330 2127315 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25263855 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1098861 1098861 1013453 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1914908 1914908 1802910 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862721 2862721 2717884 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2153110 2153110 2022120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096287 2096287 1974351 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1036630 1036630 953387 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 17201173 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2228732 2228732 2096444 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24956168 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1965917 1965917 1852410 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422822 2422822 2285744 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746672 1746672 1651648 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 57 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032250 2032250 1913721 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2537658 2537658 2399299 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 27177916 circulating tumour recurrent 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096298 2096298 1974362 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659760 2659760 2519918 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766584 COSM12371 132555223 c.1991A>T p.E664V Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97538 Variant of unknown origin 28744312 surgery-fixed NS ENSP00000395243.3:p.Glu664Val ENST00000454757.6:c.1991A>T 7:g.55173985A>T EGFR ENST00000275493.6 3633 3236 2595759 2595759 2456635 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1469347 1469347 1393086 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096219 2096219 1974283 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046035 2046035 1926330 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047772 2047772 1928044 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345386 2345386 2210058 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475381 1475381 1399080 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264155 2264155 2131139 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469444 1469444 1393183 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264175 2264175 2131159 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 921171 921171 838130 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16002952 surgery-fixed primary 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047817 2047817 1928089 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777258 1777258 1681261 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345560 2345560 2210232 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637210 1637210 1553258 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921936 1921936 1809254 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705469 1705469 1613375 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542150 1542150 1464453 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230367 1230367 1142181 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19543508 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838712 1838712 1732813 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203109 2203109 2071367 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770665 1770665 1674905 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493360 1493360 1416350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1963281 1963281 1849829 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23599349 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1541361 1541361 1463675 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21768463 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246711 1246711 1158390 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246616 1246616 1158295 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878850 2878850 2733365 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27368130 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345575 2345575 2210247 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777322 1777322 1681325 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2432378 2432378 2295281 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26458633 surgery - NOS metastasis 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1967525 1967525 1854017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23807543 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960158 1960158 1846798 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264438 2264438 2131422 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937536 1937536 1824470 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1635871 1635871 1551975 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22102479 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1746672 1746672 1651648 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469403 1469403 1393142 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469470 1469470 1393209 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 921166 921166 838125 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16002952 surgery-fixed primary 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1135345 1135345 1047911 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17591931 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983157 983157 898875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422918 2422918 2285840 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2152690 2152690 2021700 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24768118 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875681 1875681 1766264 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475382 1475382 1399081 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083475 2083475 1961758 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481316 surgery - NOS primary 50 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983098 983098 898816 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914905 1914905 1802907 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1994274 1994274 1879529 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23886169 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218521 2218521 2086532 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264117 2264117 2131101 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047771 2047771 1928043 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046059 2046059 1926354 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430061 1430061 1339479 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2350425 2350425 2214796 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23357969 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345571 2345571 2210243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2432454 2432454 2295355 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25798276 NS NS 83 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095947 2095947 1974011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421216 2421216 2284138 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469448 1469448 1393187 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096298 2096298 1974362 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1823855 1823855 1722249 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23212424 surgery-fixed primary 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046047 2046047 1926342 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2562088 2562088 2423484 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1697231 1697231 1605349 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21616658 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777215 1777215 1681218 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2595759 2595759 2456635 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1835500 1835500 1730532 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23242440 NS NS 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047782 2047782 1928054 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493330 1493330 1416320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1507380 1507380 1430249 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51794784 COSM13182 99375617 c.2203G>A p.G735S Substitution - Missense hom 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 21487925 NS NS ENSP00000275493.2:p.Gly735Ser ENST00000275493.6:c.2203G>A 7:g.55174740G>A EGFR ENST00000275493.6 3633 3236 924292 924292 841067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780206 COSM12373 99380273 c.2159C>T p.S720F Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .9768 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Ser720Phe ENST00000275493.6:c.2159C>T 7:g.55174018C>T EGFR ENST00000275493.6 3633 3236 1887421 1887421 1777093 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 B00278 2910543 2764405 ovary NS NS NS carcinoma clear_cell_carcinoma NS NS n COSV51769863 COSM1090888 99381430 c.2224G>A p.V742I Substitution - Missense 38 7:55174761-55174761 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 33947352 surgery-fixed NS ENSP00000275493.2:p.Val742Ile ENST00000275493.6:c.2224G>A 7:g.55174761G>A EGFR ENST00000275493.6 3633 3236 1887363 1887363 1777035 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637080 1637080 1553128 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1167998 1167998 1080240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19059670 surgery-fixed primary 47 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1435652 1435652 1344931 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20661086 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2675403 2675403 2534677 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264310 2264310 2131294 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264199 2264199 2131183 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095930 2095930 1973994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 12 1077311 992565 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1094003 1094003 1008705 urinary_tract bladder NS NS carcinoma NS NS NS n COSV51769451 COSM26036 133262088 c.2471A>G p.Y824C Substitution - Missense 38 7:55191855-55191855 + - PATHOGENIC .986 Reported in another cancer sample as somatic 17707060 surgery fresh/frozen NS ENSP00000415559.1:p.Tyr824Cys ENST00000455089.5:c.2471A>G 7:g.55191855A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594552 1594552 1515520 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772314 COSM27568 132552042 c.2252G>C p.G751A Substitution - Missense 38 7:55181396-55181396 + - PATHOGENIC .95257 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000395243.3:p.Gly751Ala ENST00000454757.6:c.2252G>C 7:g.55181396G>C EGFR ENST00000275493.6 3633 3236 2595745 2595745 2456621 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2046003 2046003 1926298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096019 2096019 1974083 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264113 2264113 2131097 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1668531 1668531 1581824 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226154 2226154 2093889 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083094 2083094 1961515 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24300726 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618058 1618058 1536854 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2239171 2239171 2106703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 50 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103804 1103804 1018056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18271876 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453488 1453488 1377521 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 109588 2812897 2669311 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 45 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899309 899309 816921 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098861 1098861 1013453 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2239171 2239171 2106703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767386 COSM18423 99393803 c.2500G>T p.V834L Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .9903 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 50 ENSP00000275493.2:p.Val834Leu ENST00000275493.6:c.2500G>T 7:g.55191749G>T EGFR ENST00000275493.6 3633 3236 2239171 2239171 2106703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 50 ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 1751708 1751708 1656524 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2214543 2214543 2082667 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 109588 2812897 2669311 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 45 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1881683 1881683 1771834 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23391413 NS metastasis ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2281 1188091 1099990 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19235531 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1202551 1202551 1114437 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983720 1983720 1869956 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899324 899324 816936 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862727 2862727 2717890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1434016 1434016 1343431 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1038992 1038992 955569 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226148 2226148 2093883 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459528 1459528 1383471 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1459528 1459528 1383471 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096236 2096236 1974300 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096116 2096116 1974180 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2230327 2230327 2098013 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24781527 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1983774 1983774 1870010 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1029023 1029023 945894 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17075123 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-AB-2878-03 1650370 1565157 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV51771306 COSM1318972 99391332 c.1913C>T p.T638M Substitution - Missense het 38 7:55171207-55171207 + - NEUTRAL .03249 Reported in another cancer sample as somatic 377 blood-bone marrow NS 47 ENSP00000275493.2:p.Thr638Met ENST00000275493.6:c.1913C>T 7:g.55171207C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862732 2862732 2717895 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469787 1469787 1393526 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1694975 1694975 1603195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 BL-17-G42045 2905103 2759359 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1141311 1141311 1053759 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770510 1770510 1674750 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2686018 2686018 2545053 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1567514 1567514 1489146 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM30754 178378833 c.? p.L747P Substitution - Missense + - Reported in another cancer sample as somatic 21949883 fine needle aspirate metastasis ENSP00000275493.2:p.Leu747Pro EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924292 924292 841067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780206 COSM12373 133208468 c.2024C>T p.S675F Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .9768 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Ser675Phe ENST00000455089.5:c.2024C>T 7:g.55174018C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 B00278 2910543 2764405 ovary NS NS NS carcinoma clear_cell_carcinoma NS NS n COSV51769863 COSM1090888 133209747 c.2089G>A p.V697I Substitution - Missense 38 7:55174761-55174761 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 33947352 surgery-fixed NS ENSP00000415559.1:p.Val697Ile ENST00000455089.5:c.2089G>A 7:g.55174761G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1456553 1456553 1380528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668531 1668531 1581824 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239171 2239171 2106703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 50 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239171 2239171 2106703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 50 ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239171 2239171 2106703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767386 COSM18423 133220856 c.2365G>T p.V789L Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .9903 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 50 ENSP00000415559.1:p.Val789Leu ENST00000455089.5:c.2365G>T 7:g.55191749G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675163 2675163 2534437 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51797702 COSM6849769 132578427 c.2099A>C p.K700T Substitution - Missense 38 7:55174771-55174771 + - PATHOGENIC .99622 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000395243.3:p.Lys700Thr ENST00000454757.6:c.2099A>C 7:g.55174771A>C EGFR ENST00000275493.6 3633 3236 2264128 2264128 2131112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1751708 1751708 1656524 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862721 2862721 2717884 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-G42045 2905103 2759359 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 H1355 2776233 2634369 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51859380 COSM3266668 132552892 c.3342G>C p.Q1114H Substitution - Missense 38 7:55205461-55205461 + - PATHOGENIC .7741 Variant of unknown origin 29681454 NS NS 53 ENSP00000395243.3:p.Gln1114His ENST00000454757.6:c.3342G>C 7:g.55205461G>C EGFR ENST00000275493.6 3633 3236 1308514 1308514 1219459 thyroid NS NS NS carcinoma medullary_carcinoma NS NS n COSM36938 178387357 c.? p.I759V Substitution - Missense + - Variant of unknown origin 19776290 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 BL-18-K35709 2905399 2759655 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51847987 COSM4384128 99386272 c.2866G>A p.D956N Substitution - Missense 38 7:55200333-55200333 + - PATHOGENIC .99504 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Asp956Asn ENST00000275493.6:c.2866G>A 7:g.55200333G>A EGFR ENST00000275493.6 3633 3236 2426867 2426867 2289788 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25561229 NS NS 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1694962 1694962 1603182 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264153 2264153 2131137 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 HCC149 2776336 2634472 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29681454 NS NS 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631954 1631954 1548824 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891232 1891232 1780601 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1549827 1549827 1471932 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895124 1895124 1783816 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 11-18 946048 862574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914815 914815 832264 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602798 1602798 1522134 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1000048 1000048 917271 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592984 1592984 1513910 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1738902 1738902 1644733 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924332 924332 841107 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089595 1089595 1004542 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897834 897834 815456 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1931646 1931646 1818936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594555 1594555 1515523 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891280 1891280 1780649 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1135415 1135415 1047979 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2057513 2057513 1937720 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24255770 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1965852 1965852 1852345 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345070 2345070 2209742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1983805 1983805 1870041 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1459523 1459523 1383466 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 897817 897817 815439 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1838666 1838666 1732767 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AB-2878-03 1650370 1565157 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV51771306 COSM1318972 133218950 c.1778C>T p.T593M Substitution - Missense het 38 7:55171207-55171207 + - NEUTRAL .03249 Reported in another cancer sample as somatic 377 blood-bone marrow NS 47 ENSP00000415559.1:p.Thr593Met ENST00000455089.5:c.1778C>T 7:g.55171207C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1694975 1694975 1603195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1202554 1202554 1114440 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 MG-205-tumor 2819087 2675386 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2105818 2105818 1983856 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120933 1120933 1034089 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1355118 1355118 1265213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025442 2025442 1907531 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2076972 2076972 1955721 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed recurrent 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887404 1887404 1777076 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076948 2076948 1955697 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24369725 surgery-fixed metastasis 48 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2147907 2147907 2017050 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51793006 COSM3727812 133221820 c.2101_2106delinsAATTAT p.E701_L702delinsNY Substitution - Missense 38 7:55174773-55174778 + - Variant of unknown origin 24722155 surgery-fixed metastasis 68 ENSP00000415559.1:p.Glu701_Leu702delinsAsnTyr ENST00000455089.5:c.2101_2106delinsAATTAT 7:g.55174773_55174778delinsAATTAT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983769 1983769 1870005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594597 1594597 1515565 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895065 1895065 1783757 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 G22 1063236 979281 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983723 1983723 1869959 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 24 1077323 992577 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983722 1983722 1869958 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891193 1891193 1780562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990916 1990916 1876251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429298 1429298 1338749 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 896919 896919 814542 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15329413 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895080 1895080 1783772 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1884155 1884155 1774042 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089601 1089601 1004548 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1627729 1627729 1544641 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-099-tumor 2819026 2675325 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983774 1983774 1870010 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DM26 2466862 2329693 skin scalp NS NS malignant_melanoma desmoplastic NS NS n COSV51820811 COSM5611257 132595299 c.1653_1654delinsAA p.A552T Substitution - Missense 38 7:55165345-55165346 + - Variant of unknown origin 26343386 surgery-fixed NS 79 ENSP00000395243.3:p.Ala552Thr ENST00000454757.6:c.1653_1654delinsAA 7:g.55165345_55165346delinsAA EGFR ENST00000275493.6 3633 3236 2264257 2264257 2131241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664344 2664344 2524414 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1746663 1746663 1651639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 52 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1097634 1097634 1012295 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1097634 1097634 1012295 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106549 2106549 1984412 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163636 2163636 2032129 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24793378 surgery - NOS NS 58 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1694962 1694962 1603182 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2579301 2579301 2440638 NS NS NS NS malignant_melanoma NS NS NS n COSV51772282 COSM133202 132556800 c.2201G>A p.G734D Substitution - Missense 38 7:55181345-55181345 + - PATHOGENIC .98244 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000395243.3:p.Gly734Asp ENST00000454757.6:c.2201G>A 7:g.55181345G>A EGFR ENST00000275493.6 3633 3236 1450923 1450923 1375066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264089 2264089 2131073 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637136 1637136 1553184 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2064726 2064726 1944803 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1964328 1964328 1850863 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897817 897817 815439 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1202554 1202554 1114440 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895065 1895065 1783757 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1891166 1891166 1780535 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1493341 1493341 1416331 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230471 1230471 1142285 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479927 1479927 1403587 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1731102 1731102 1637073 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22815900 pleural effusion recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1980062 1980062 1866305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 76 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1770603 1770603 1674843 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1855992 1855992 1748545 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667706 1667706 1580999 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844509 1844509 1737543 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23154768 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1980995 1980995 1867236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23842453 surgery fresh/frozen primary 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983725 1983725 1869961 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2153113 2153113 2022123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1838679 1838679 1732780 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1213655 1213655 1125522 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18978556 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2906639 2906639 2760890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29616327 surgery-fixed primary 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029038 2029038 1910920 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2011072 2011072 1893710 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450923 1450923 1375066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602595 1602595 1521931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22082647 surgery-fixed primary 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469790 1469790 1393529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2665702 2665702 2525411 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28978102 surgery - NOS recurrent 75 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2665702 2665702 2525411 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS recurrent 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875340 1875340 1765923 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1573770 1573770 1495239 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21982684 surgery fresh/frozen primary 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1094002 1094002 1008704 urinary_tract bladder NS NS carcinoma NS NS NS n COSV51789830 COSM26035 132556581 c.2456C>A p.A819E Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .95798 Variant of unknown origin 17707060 surgery fresh/frozen NS ENSP00000395243.3:p.Ala819Glu ENST00000454757.6:c.2456C>A 7:g.55191840C>A EGFR ENST00000275493.6 3633 3236 1887407 1887407 1777079 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1931637 1931637 1818927 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1874741 1874741 1765332 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965899 1965899 1852392 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1481231 1481231 1404860 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980062 1980062 1866305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 76 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064726 2064726 1944803 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1965811 1965811 1852304 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1168007 1168007 1080249 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618627 1618627 1537379 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 80 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076941 2076941 1955690 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed NS 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1648536 1648536 1563491 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 99377339 c.2239_2240delinsCC p.L747P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000275493.2:p.Leu747Pro ENST00000275493.6:c.2239_2240delinsCC 7:g.55174776_55174777delinsCC EGFR ENST00000275493.6 3633 3236 1732079 1732079 1638045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21622214 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862257 2862257 2717447 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25969368 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1610983 1610983 1530211 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22157369 surgery-fixed NS 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705344 1705344 1613328 lung right_middle_lobe NS NS carcinoma large_cell_carcinoma NS NS n COSV51789625 COSM13197 99376708 c.2590G>A p.A864T Substitution - Missense 38 7:55191839-55191839 + - PATHOGENIC .9615 Reported in another cancer sample as somatic 22722798 NS NS 59 ENSP00000275493.2:p.Ala864Thr ENST00000275493.6:c.2590G>A 7:g.55191839G>A EGFR ENST00000275493.6 3633 3236 1635371 1635371 1551876 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22335887 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148626 2148626 2017756 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459509 1459509 1383452 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2033590 2033590 1915039 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 24137397 surgery fresh/frozen NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1770691 1770691 1674931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264231 2264231 2131215 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1097640 1097640 1012301 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141324 1141324 1053772 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 G6 1063231 979276 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 84 ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 G6 1063231 979276 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 84 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1513470 1513470 1436131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21497370 fixed - NOS primary 51 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1875363 1875363 1765946 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1874735 1874735 1765326 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1967530 1967530 1854022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23807543 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1103766 1103766 1018018 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 59 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096250 2096250 1974314 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891166 1891166 1780535 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479927 1479927 1403587 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2672932 2672932 2532449 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM34167 178379046 c.? p.G598V Substitution - Missense + - Reported in another cancer sample as somatic 26191234 surgery-fixed primary ENSP00000275493.2:p.Gly598Val EGFR ENST00000275493.6 3633 3236 1587197 1587197 1508368 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS 34 ENSP00000275493.2:p.Leu861Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592964 1592964 1513890 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51801589 COSM133199 132554773 c.2111A>G p.E704G Substitution - Missense 38 7:55174783-55174783 + - PATHOGENIC .9946 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000395243.3:p.Glu704Gly ENST00000454757.6:c.2111A>G 7:g.55174783A>G EGFR ENST00000275493.6 3633 3236 1734961 1734961 1640905 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264316 2264316 2131300 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770731 1770731 1674971 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 NPC0001PT00332T00332 2857343 2712643 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 CCK81 2301965 2167248 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51765999 COSM3266658 99407147 c.3206A>G p.Y1069C Substitution - Missense het 38 7:55202560-55202560 + - PATHOGENIC .97752 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000275493.2:p.Tyr1069Cys ENST00000275493.6:c.3206A>G 7:g.55202560A>G EGFR ENST00000275493.6 3633 3236 2096276 2096276 1974340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2096276 2096276 1974340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096276 2096276 1974340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2096276 2096276 1974340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2151456 2151456 2020488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24742923 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468090 1468090 1391936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2680752 2680752 2540025 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 46 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345348 2345348 2210020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895151 1895151 1783843 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264341 2264341 2131325 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120935 1120935 1034091 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246656 1246656 1158335 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421209 2421209 2284131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637217 1637217 1553265 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474458 2474458 2337227 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964335 1964335 1850870 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2345108 2345108 2209780 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1444783 1444783 1369026 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618065 1618065 1536861 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1661847 1661847 1575460 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22487432 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118432 2118432 1992667 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2595768 2595768 2456644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1166943 178385114 c.? p.V769L Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Val769Leu EGFR ENST00000275493.6 3633 3236 MG-099-tumor 2819026 2675325 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5330 915979 833378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51861323 COSM13187 132619161 c.2413C>A p.H805N Substitution - Missense 38 7:55191797-55191797 + - PATHOGENIC .98386 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000395243.3:p.His805Asn ENST00000454757.6:c.2413C>A 7:g.55191797C>A EGFR ENST00000275493.6 3633 3236 1479923 1479923 1403583 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1445192 1445192 1369435 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20682976 surgery - NOS metastasis 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444796 1444796 1369039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226877 2226877 2094612 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2027783 2027783 1909686 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402481 2402481 2265337 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 76 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1672417 1672417 1585471 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21729655 fine needle aspirate metastasis 45 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2081896 2081896 1960318 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081896 2081896 1960318 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1135351 1135351 1047917 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17591931 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1086851 1086851 1001866 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17848912 surgery-fixed NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1196943 1196943 1108838 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844342 1844342 1737376 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602595 1602595 1521931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22082647 surgery-fixed primary 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875340 1875340 1765923 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1573770 1573770 1495239 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21982684 surgery fresh/frozen primary 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1648536 1648536 1563491 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 133205309 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000415559.1:p.Leu702Pro ENST00000455089.5:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000455089 ENST00000455089.5 3276 3236 3791 915999 833398 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51784752 COSM13199 133204015 c.2483G>A p.G828E Substitution - Missense 38 7:55191867-55191867 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000415559.1:p.Gly828Glu ENST00000455089.5:c.2483G>A 7:g.55191867G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1931637 1931637 1818927 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1168007 1168007 1080249 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-17-J18549 2905628 2759884 NS NS NS NS malignant_melanoma NS NS NS n COSV105864529 COSM9997996 132605646 c.2789C>T p.P930L Substitution - Missense 38 7:55200391-55200391 + - PATHOGENIC .98929 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Pro930Leu ENST00000454757.6:c.2789C>T 7:g.55200391C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 4538 915998 833397 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765668 COSM13198 132553967 c.2461G>A p.E821K Substitution - Missense 38 7:55191845-55191845 + - PATHOGENIC .98912 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000395243.3:p.Glu821Lys ENST00000454757.6:c.2461G>A 7:g.55191845G>A EGFR ENST00000275493.6 3633 3236 3791 915999 833398 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51784752 COSM13199 99375727 c.2618G>A p.G873E Substitution - Missense 38 7:55191867-55191867 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000275493.2:p.Gly873Glu ENST00000275493.6:c.2618G>A 7:g.55191867G>A EGFR ENST00000275493.6 3633 3236 1891306 1891306 1780675 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1637201 1637201 1553249 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468065 1468065 1391911 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS recurrent 48 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983725 1983725 1869961 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1141283 1141283 1053731 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1526360 1526360 1448729 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21623281 fine needle aspirate NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2406811 2406811 2269691 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 48 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983127 983127 898845 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476877 2476877 2339646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1052962 1052962 969033 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17410005 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345113 2345113 2209785 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 G6 1063231 979276 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 84 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 G6 1063231 979276 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 84 ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 21 2626696 2487087 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 27322425 surgery-fixed metastasis ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1213652 1213652 1125519 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18978556 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1334743 1334743 1245128 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20401612 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 911627 911627 829110 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2260331 2260331 2127316 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25263855 fine needle aspirate NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1874737 1874737 1765328 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875363 1875363 1765946 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103766 1103766 1018018 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 59 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618618 1618618 1537370 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 84 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2045957 2045957 1926252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2141455 2141455 2010673 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24636848 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2476840 2476840 2339609 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2008977 2008977 1891711 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23979198 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1467300 1467300 1391146 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 20940188 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2402484 2402484 2265340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 56 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2603091 2603091 2463982 NS NS NS NS carcinoma adenocarcinoma of_unknown_primary NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 26182302 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2449909 2449909 2312746 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26612314 surgery - NOS recurrent 70 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2664348 2664348 2524416 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 50 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2664348 2664348 2524416 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 50 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1705344 1705344 1613328 lung right_middle_lobe NS NS carcinoma large_cell_carcinoma NS NS n COSV51789625 COSM13197 133204854 c.2455G>A p.A819T Substitution - Missense 38 7:55191839-55191839 + - PATHOGENIC .9615 Reported in another cancer sample as somatic 22722798 NS NS 59 ENSP00000415559.1:p.Ala819Thr ENST00000455089.5:c.2455G>A 7:g.55191839G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1734961 1734961 1640905 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1179667 1179667 1091629 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664375 2664375 2524430 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 54 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1083799 1083799 998964 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345476 2345476 2210148 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1047871 1047871 964100 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17228019 surgery - NOS NS 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1434018 1434018 1343433 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2680608 2680608 2539881 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095916 2095916 1973980 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00332T00332 2857343 2712643 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 914803 914803 832252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1914968 1914968 1802970 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2595758 2595758 2456634 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2595768 2595768 2456644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2595748 2595748 2456624 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2878785 2878785 2733300 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22006985 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2055996 2055996 1936240 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24221342 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983160 983160 898878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731389 1731389 1637355 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22457323 NS NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966331 1966331 1852824 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638767 1638767 1554766 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120931 1120931 1034087 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1997143 1997143 1882352 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23930206 fixed - NOS metastasis 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264300 2264300 2131284 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230461 1230461 1142275 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1112965 1112965 1026476 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448997 surgery-fixed NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118446 2118446 1992681 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240675 2240675 2108206 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 38 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1668665 1668665 1581957 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22523351 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264292 2264292 2131276 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045957 2045957 1926252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777261 1777261 1681264 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983151 983151 898869 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118436 2118436 1992671 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1512561 1512561 1435245 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21362302 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895151 1895151 1783843 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479923 1479923 1403583 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CCK81 2301965 2167248 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51765999 COSM3266658 133233818 c.3071A>G p.Y1024C Substitution - Missense het 38 7:55202560-55202560 + - PATHOGENIC .97752 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000415559.1:p.Tyr1024Cys ENST00000455089.5:c.3071A>G 7:g.55202560A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2626094 2626094 2486506 lung NS NS NS carcinoid-endocrine_tumour atypical NS NS n COSV51823853 COSM6191491 132547110 c.311T>A p.L104Q Substitution - Missense hom 38 7:55143375-55143375 + - PATHOGENIC .99116 Variant of unknown origin 26645239 surgery-fixed NS ENSP00000395243.3:p.Leu104Gln ENST00000454757.6:c.311T>A 7:g.55143375T>A EGFR ENST00000275493.6 3633 3236 1174318 1174318 1086337 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1456581 1456581 1380556 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2029013 2029013 1910895 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618612 1618612 1537364 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 78 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1777280 1777280 1681283 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2141457 2141457 2010675 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24636848 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345431 2345431 2210103 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770532 1770532 1674772 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547793 1547793 1469915 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed primary 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422787 2422787 2285709 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2432457 2432457 2295358 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25798276 NS NS 85 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1162979 1162979 1075302 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18992959 NS recurrent 84 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777225 1777225 1681228 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874660 1874660 1765251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1113034 1113034 1026535 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18458038 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838690 1838690 1732791 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469492 1469492 1393231 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096031 2096031 1974095 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1610412 1610412 1529652 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22142557 pleural effusion NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096151 2096151 1974215 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029016 2029016 1910898 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542142 1542142 1464445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2498855 2498855 2361206 lung left_upper_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27133750 surgery - NOS primary 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2141455 2141455 2010673 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24636848 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838716 1838716 1732817 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096147 2096147 1974211 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237672 1237672 1149419 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008977 2008977 1891711 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23979198 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887373 1887373 1777045 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1856197 1856197 1748750 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937569 1937569 1824503 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777368 1777368 1681371 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1075008 1075008 990262 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1597344 1597344 1517832 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19643949 surgery - NOS NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279096 1279096 1190392 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed primary 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1498201 1498201 1421079 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21220471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637130 1637130 1553178 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656136 1656136 1570793 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21311943 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469501 1469501 1393240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045997 2045997 1926292 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887396 1887396 1777068 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1112949 1112949 1026460 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448997 surgery-fixed NS 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2603091 2603091 2463982 NS NS NS NS carcinoma adenocarcinoma of_unknown_primary NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26182302 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965904 1965904 1852397 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983103 983103 898821 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777379 1777379 1681382 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1732075 1732075 1638041 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21622214 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549150 2549150 2410605 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885184 1885184 1775071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770631 1770631 1674871 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240544 2240544 2108075 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25227801 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246691 1246691 1158370 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047777 2047777 1928049 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549141 2549141 2410596 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838732 1838732 1732833 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2271432 2271432 2138061 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25257380 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838726 1838726 1732827 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770624 1770624 1674864 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-16-G30012 2905599 2759855 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51815598 COSM6471954 133220741 c.1190G>T p.S397I Substitution - Missense 38 7:55160165-55160165 + - NEUTRAL .44157 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Ser397Ile ENST00000455089.5:c.1190G>T 7:g.55160165G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 G22 1063236 979281 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 75 ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 1514602 1514602 1437212 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21558399 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148590 2148590 2017720 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844345 1844345 1737379 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095899 2095899 1973963 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2260323 2260323 2127308 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25263855 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014309 1014309 931483 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1213656 1213656 1125523 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18978556 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2131906 2131906 2005969 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24376723 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838562 1838562 1732663 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345566 2345566 2210238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591084 1591084 1512200 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095902 2095902 1973966 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141282 1141282 1053730 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525716 2525716 2387904 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525716 2525716 2387904 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1042904 1042904 959245 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770561 1770561 1674801 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2009155 2009155 1891889 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1914960 1914960 1802962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1098862 1098862 1013454 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2000065 2000065 1884963 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS 45 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1279099 1279099 1190395 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed metastasis 37 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921919 1921919 1809237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729741 1729741 1635712 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM30754 178378833 c.? p.L747P Substitution - Missense + - Reported in another cancer sample as somatic 22805266 NS NS ENSP00000275493.2:p.Leu747Pro EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239179 2239179 2106711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 70 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162181 1162181 1074513 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780223 COSM28511 132566687 c.1973T>C p.L658P Substitution - Missense 38 7:55173967-55173967 + - PATHOGENIC .90657 Variant of unknown origin 19020901 NS NS ENSP00000395243.3:p.Leu658Pro ENST00000454757.6:c.1973T>C 7:g.55173967T>C EGFR ENST00000275493.6 3633 3236 1734081 1734081 1640030 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22842370 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2626141 2626141 2486553 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51817684 COSM6191493 99436845 c.2576C>T p.A859V Substitution - Missense 38 7:55191825-55191825 + - PATHOGENIC .97885 Variant of unknown origin 26645239 surgery-fixed NS ENSP00000275493.2:p.Ala859Val ENST00000275493.6:c.2576C>T 7:g.55191825C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226877 2226877 2094612 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 G719S-GR 2772831 2631013 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 29594878 pleural effusion recurrent 89 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 G719S-GR 2772831 2631013 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 29594878 pleural effusion recurrent 89 ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 1770539 1770539 1674779 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2757124 2757124 2615767 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 99375713 c.2318A>T p.H773L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 29858019 surgery - NOS NS 50 ENSP00000275493.2:p.His773Leu ENST00000275493.6:c.2318A>T 7:g.55181327A>T EGFR ENST00000275493.6 3633 3236 2757124 2757124 2615767 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 29858019 surgery - NOS NS 50 ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 2203100 2203100 2071358 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1098864 1098864 1013456 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1434018 1434018 1343433 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618613 1618613 1537365 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 80 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1141278 1141278 1053726 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1599034 1599034 1519521 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 22091430 fixed - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1434452 1434452 1343810 eye conjunctiva NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51768262 COSM26445 133205089 c.2165C>T p.A722V Substitution - Missense 38 7:55181309-55181309 + - PATHOGENIC .97799 Reported in another cancer sample as somatic 20498858 fixed - NOS NS ENSP00000415559.1:p.Ala722Val ENST00000455089.5:c.2165C>T 7:g.55181309C>T EGFR ENST00000275493.6 3633 3236 E6 1303892 1214943 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20036793 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422926 2422926 2285848 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891175 1891175 1780544 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777214 1777214 1681217 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1738931 1738931 1644762 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 MG-266-tumor 2819117 2675416 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1891171 1891171 1780540 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1734158 1734158 1640107 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22843912 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587272 1587272 1508443 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264343 2264343 2131327 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637691 2637691 2498064 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096036 2096036 1974100 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1113035 1113035 1026536 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18458038 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914803 914803 832252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1500178 1500178 1423057 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1714999 1714999 1622578 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22710815 surgery-fixed metastasis 71 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1038998 1038998 955575 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891178 1891178 1780547 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895150 1895150 1783842 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1991296 1991296 1876631 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1197354 1197354 1109249 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891205 1891205 1780574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983750 1983750 1869986 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983835 1983835 1870071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891204 1891204 1780573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 G1 1063227 979272 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 65 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239179 2239179 2106711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983826 1983826 1870062 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631960 1631960 1548830 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631950 1631950 1548820 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 11 1433976 1343391 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 81 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-GE057-T1 2869770 2724767 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110798 COSM9656412 132619806 c.2944_2945delinsTT p.P982F Substitution - Missense 38 7:55201320-55201321 + - Variant of unknown origin 26950094 surgery - NOS NS 89 ENSP00000395243.3:p.Pro982Phe ENST00000454757.6:c.2944_2945delinsTT 7:g.55201320_55201321delinsTT EGFR ENST00000275493.6 3633 3236 2345380 2345380 2210052 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770715 1770715 1674955 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1668664 1668664 1581956 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22523351 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1980081 1980081 1866324 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 65 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-027-tumor 2818987 2675286 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0002PT00013T00013 2857370 2712670 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00221T00221 2857376 2712676 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 109618 2812909 2669323 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 52 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-125-tumor 2819044 2675343 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-266-tumor 2819117 2675416 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1456581 1456581 1380556 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098862 1098862 1013454 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 2425755 2425755 2288676 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081825 2081825 1960247 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481317 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891294 1891294 1780663 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 G719S-GR 2772831 2631013 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 29594878 pleural effusion recurrent 89 ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 G719S-GR 2772831 2631013 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 29594878 pleural effusion recurrent 89 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042904 1042904 959245 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009155 2009155 1891889 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098864 1098864 1013456 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1896940 1896940 1785627 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23542356 surgery-fixed recurrent 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921929 1921929 1809247 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1126994 1126994 1039848 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18549475 surgery fresh/frozen primary 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891240 1891240 1780609 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1444744 1444744 1368987 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 KYSE-270 1876247 1766830 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23426935 cell-line NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 924339 924339 841114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1196958 1196958 1108853 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 SJHYPO052 2301072 2166353 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 99381154 c.1279C>T p.R427C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Reported in another cancer sample as somatic 638 NS NS ENSP00000275493.2:p.Arg427Cys ENST00000275493.6:c.1279C>T 7:g.55157734C>T EGFR ENST00000275493.6 3633 3236 2474448 2474448 2337217 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2439528 2439528 2302368 lung NS NS NS carcinoma invasive_mucinous_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24119562 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 911627 911627 829110 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891175 1891175 1780544 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1823873 1823873 1722267 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23212424 surgery-fixed primary 61 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625579 2625579 2485991 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 74 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-K52205 2905639 2759895 NS NS NS NS malignant_melanoma NS NS NS n COSV51783368 COSM6196862 133221071 c.2086C>T p.P696S Substitution - Missense 38 7:55174758-55174758 + - PATHOGENIC .99382 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Pro696Ser ENST00000455089.5:c.2086C>T 7:g.55174758C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891171 1891171 1780540 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00243T00243 2857340 2712640 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105111181 COSM9542450 132574470 c.61G>A p.A21T Substitution - Missense 38 7:55019338-55019338 + - NEUTRAL .06121 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000395243.3:p.Ala21Thr ENST00000454757.6:c.61G>A 7:g.55019338G>A EGFR ENST00000275493.6 3633 3236 1668671 1668671 1581963 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 22523351 fixed - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1285228 1285228 1196508 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM34166 178380439 c.? p.R108K Substitution - Missense hom + - Reported in another cancer sample as somatic 19789313 surgery - NOS NS ENSP00000275493.2:p.Arg108Lys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2538973 2538973 2400568 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 133205309 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 27499993 circulating tumour NS 61 ENSP00000415559.1:p.Leu702Pro ENST00000455089.5:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2757124 2757124 2615767 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 29858019 surgery - NOS NS 50 ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2757124 2757124 2615767 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 133203995 c.2183A>T p.H728L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 29858019 surgery - NOS NS 50 ENSP00000415559.1:p.His728Leu ENST00000455089.5:c.2183A>T 7:g.55181327A>T EGFR ENST00000275493.6 3633 3236 1074939 1074939 990193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879494 1879494 1769996 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1493353 1493353 1416343 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891239 1891239 1780608 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1459499 1459499 1383442 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-06-0157-01 1910184 1798475 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 63 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1664590 1664590 1578040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21899495 pleural effusion NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515245 1515245 1437855 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148586 2148586 2017716 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118427 2118427 1992662 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983878 983878 899595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 16733218 surgery-fixed primary ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 983878 983878 899595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 16733218 surgery-fixed primary ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891294 1891294 1780663 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1738931 1738931 1644762 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924339 924339 841114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1964304 1964304 1850839 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226164 2226164 2093899 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891240 1891240 1780609 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2579677 2579677 2441014 NS NS NS NS malignant_melanoma NS NS NS n COSV51804547 COSM6005741 132575428 c.2163G>A p.M721I Substitution - Missense 38 7:55181307-55181307 + - PATHOGENIC .98539 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000395243.3:p.Met721Ile ENST00000454757.6:c.2163G>A 7:g.55181307G>A EGFR ENST00000275493.6 3633 3236 LUAD-NYU608 1765135 1669455 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51772147 COSM375343 99393933 c.1934C>G p.S645C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 64 ENSP00000275493.2:p.Ser645Cys ENST00000275493.6:c.1934C>G 7:g.55172997C>G EGFR ENST00000275493.6 3633 3236 2525696 2525696 2387885 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 27304188 NS NS ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 2525696 2525696 2387885 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27304188 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1542160 1542160 1464463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2239179 2239179 2106711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 70 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1302295 1302295 1213346 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096175 2096175 1974239 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732886 2732886 2591639 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779091 COSM2155593 133216524 c.953C>T p.T318I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 50 ENSP00000415559.1:p.Thr318Ile ENST00000455089.5:c.953C>T 7:g.55156614C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-112-tumor 2819035 2675334 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 8 2760115 2618648 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51797913 COSM7339051 132556491 c.2370C>A p.H790Q Substitution - Missense 38 7:55191754-55191754 + - PATHOGENIC .83351 Variant of unknown origin 29876005 surgery-fixed NS ENSP00000395243.3:p.His790Gln ENST00000454757.6:c.2370C>A 7:g.55191754C>A EGFR ENST00000275493.6 3633 3236 MG-112-tumor 2819035 2675334 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2064722 2064722 1944799 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778590 2778590 2636644 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV99296732 COSM7410339 132578479 c.2317T>C p.C773R Substitution - Missense 38 7:55181461-55181461 + - PATHOGENIC .95365 Variant of unknown origin 24372748 surgery-fixed NS ENSP00000395243.3:p.Cys773Arg ENST00000454757.6:c.2317T>C 7:g.55181461T>C EGFR ENST00000275493.6 3633 3236 2057477 2057477 1937685 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24236184 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459492 1459492 1383435 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2096291 2096291 1974355 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1029248 1029248 946119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16921488 pleural effusion NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1081606 1081606 996825 lung right_middle_lobe NS NS other hyperplasia NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17618248 surgery-fixed NS 42 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1575159 1575159 1496600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1310471 1310471 1221416 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1141291 1141291 1053739 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732917 2732917 2591670 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827197 COSM7002281 132587826 c.1649G>A p.C550Y Substitution - Missense 38 7:55165341-55165341 + - PATHOGENIC .99683 Variant of unknown origin 28855349 surgery - NOS primary 39 ENSP00000395243.3:p.Cys550Tyr ENST00000454757.6:c.1649G>A 7:g.55165341G>A EGFR ENST00000275493.6 3633 3236 1879544 1879544 1770046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1637200 1637200 1553248 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2069647 2069647 1949052 skin NS NS NS malignant_melanoma acral_lentiginous NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22437319 surgery-fixed primary 73 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1551569 1551569 1473674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1585368 1585368 1506689 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22011666 blood-bone marrow recurrent ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1514614 1514614 1437224 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21558399 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345087 2345087 2209759 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2096305 2096305 1974369 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594588 1594588 1515556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51776191 COSM133565 132559384 c.2252G>A p.G751D Substitution - Missense 38 7:55181396-55181396 + - PATHOGENIC .96481 Variant of unknown origin 19724844 surgery-fixed NS ENSP00000395243.3:p.Gly751Asp ENST00000454757.6:c.2252G>A 7:g.55181396G>A EGFR ENST00000275493.6 3633 3236 1465901 1465901 1389748 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 68 ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980081 1980081 1866324 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 65 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1074939 1074939 990193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1668672 1668672 1581964 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 22523351 fixed - NOS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1668672 1668672 1581964 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 22523351 fixed - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2081822 2081822 1960244 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481317 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965906 1965906 1852399 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637067 1637067 1553115 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SJHYPO052 2301072 2166353 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 133209467 c.1144C>T p.R382C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Reported in another cancer sample as somatic 638 NS NS ENSP00000415559.1:p.Arg382Cys ENST00000455089.5:c.1144C>T 7:g.55157734C>T EGFR ENST00000275493.6 3633 3236 1668535 1668535 1581828 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345797 2345797 2210469 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 914816 914816 832265 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765252 COSM13009 99400543 c.2126A>G p.E709G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000275493.2:p.Glu709Gly ENST00000275493.6:c.2126A>G 7:g.55173985A>G EGFR ENST00000275493.6 3633 3236 914816 914816 832265 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891239 1891239 1780608 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0157-01 1910184 1798475 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 63 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302295 1302295 1213346 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879494 1879494 1769996 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1089137 1089137 1004091 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1937556 1937556 1824490 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 914813 914813 832262 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-NYU608 1765135 1669455 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51772147 COSM375343 133220930 c.1799C>G p.S600C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 64 ENSP00000415559.1:p.Ser600Cys ENST00000455089.5:c.1799C>G 7:g.55172997C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675162 2675162 2534436 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51843096 COSM6849768 132552403 c.2111A>T p.E704V Substitution - Missense 38 7:55174783-55174783 + - PATHOGENIC .99468 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000395243.3:p.Glu704Val ENST00000454757.6:c.2111A>T 7:g.55174783A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2841802 2841802 2697351 soft_tissue fibrous_tissue_and_uncertain_origin NS NS desmoid_tumour-fibromatosis NS NS NS n COSV104576752 COSM9414781 132579088 c.3056G>A p.S1019N Substitution - Missense 38 7:55202545-55202545 + - PATHOGENIC .89459 Variant of unknown origin 32099073 surgery-fixed NS ENSP00000395243.3:p.Ser1019Asn ENST00000454757.6:c.3056G>A 7:g.55202545G>A EGFR ENST00000275493.6 3633 3236 1733685 1733685 1639634 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22836289 surgery-fixed NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451209 1451209 1375352 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 914810 914810 832259 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983702 1983702 1869938 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983771 1983771 1870007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1549837 1549837 1471942 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1110459 1110459 1024337 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1103632 1103632 1017884 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 55 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2616332 2616332 2476818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26118982 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983721 1983721 1869957 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 914806 914806 832255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983836 1983836 1870072 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875348 1875348 1765931 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1931644 1931644 1818934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2372583 2372583 2235376 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1876993 1876993 1767555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1593023 1593023 1513949 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899314 899314 816926 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1202555 1202555 1114441 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1310476 1310476 1221421 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1625792 1625792 1543016 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983783 1983783 1870019 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1103751 1103751 1018003 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064722 2064722 1944799 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 G22 1063236 979281 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 75 ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668535 1668535 1581828 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879544 1879544 1770046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 NPC0002PT00013T00013 2857370 2712670 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 MG-125-tumor 2819044 2675343 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 MG-027-tumor 2818987 2675286 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00221T00221 2857376 2712676 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 109618 2812909 2669323 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 52 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2035480 2035480 1916842 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24034463 surgery - NOS NS 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096094 2096094 1974158 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2823658 2823658 2679510 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31157314 surgery - NOS recurrent 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 897848 897848 815470 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MM1S 2809756 2666426 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV51776216 COSM1235506 132597110 c.2614G>C p.G872R Substitution - Missense het 38 7:55198764-55198764 + - PATHOGENIC .9843 Variant of unknown origin 30545397 cell-line NS ENSP00000395243.3:p.Gly872Arg ENST00000454757.6:c.2614G>C 7:g.55198764G>C EGFR ENST00000275493.6 3633 3236 897848 897848 815470 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1648525 1648525 1563480 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1648525 1648525 1563480 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1469947 1469947 1393686 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51774667 COSM53194 99382658 c.2197C>T p.P733S Substitution - Missense het 38 7:55174734-55174734 + - PATHOGENIC .99806 Reported in another cancer sample as somatic 20873989 surgery fresh/frozen primary ENSP00000275493.2:p.Pro733Ser ENST00000275493.6:c.2197C>T 7:g.55174734C>T EGFR ENST00000275493.6 3633 3236 1980075 1980075 1866318 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 54 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2000152 2000152 1885050 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881889 1881889 1772040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346489 2346489 2211152 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1469368 1469368 1393107 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089137 1089137 1004091 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1575159 1575159 1496600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1310471 1310471 1221416 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897848 897848 815470 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897848 897848 815470 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1648525 1648525 1563480 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1648525 1648525 1563480 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1469947 1469947 1393686 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51774667 COSM53194 133211250 c.2062C>T p.P688S Substitution - Missense het 38 7:55174734-55174734 + - PATHOGENIC .99806 Reported in another cancer sample as somatic 20873989 surgery fresh/frozen primary ENSP00000415559.1:p.Pro688Ser ENST00000455089.5:c.2062C>T 7:g.55174734C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914813 914813 832262 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1500583 1500583 1423462 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51765742 COSM87019 132550498 c.2267A>G p.Y756C Substitution - Missense het 38 7:55181411-55181411 + - PATHOGENIC .95822 Variant of unknown origin 21436633 surgery - NOS NS 83 ENSP00000395243.3:p.Tyr756Cys ENST00000454757.6:c.2267A>G 7:g.55181411A>G EGFR ENST00000275493.6 3633 3236 1882221 1882221 1772372 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 23392229 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1882221 1882221 1772372 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23392229 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2260324 2260324 2127309 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25263855 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1707039 1707039 1614945 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22695392 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1707039 1707039 1614945 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22695392 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966337 1966337 1852830 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2046061 2046061 1926356 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203084 2203084 2071342 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1107777 1107777 1021680 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914816 914816 832265 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914816 914816 832265 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765252 COSM13009 133225791 c.1991A>G p.E664G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000415559.1:p.Glu664Gly ENST00000455089.5:c.1991A>G 7:g.55173985A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 G1 1063227 979272 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 65 ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 2855910 2855910 2711313 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV104368998 COSM9232920 99392201 c.886C>T p.P296S Substitution - Missense 38 7:55154149-55154149 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 32269842 surgery-fixed NS 58 ENSP00000275493.2:p.Pro296Ser ENST00000275493.6:c.886C>T 7:g.55154149C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2035480 2035480 1916842 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24034463 surgery - NOS NS 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897799 897799 815421 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2772830 2772830 2631012 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 29594878 surgery - NOS recurrent 89 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1895165 1895165 1783857 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1113263 1113263 1026764 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18449007 surgery fresh/frozen NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095941 2095941 1974005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1334748 1334748 1245133 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20401612 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174293 1174293 1086312 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444773 1444773 1369016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914912 1914912 1802914 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046020 2046020 1926315 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469785 1469785 1393524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1602806 1602806 1522142 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980075 1980075 1866318 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 54 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043868 1043868 960209 lung NS NS NS carcinoma spindle_cell_carcinoma NS NS n COSV51770611 COSM22993 132591218 c.2027G>A p.G676D Substitution - Missense 38 7:55174021-55174021 + - PATHOGENIC .98289 Variant of unknown origin 17192902 NS NS ENSP00000395243.3:p.Gly676Asp ENST00000454757.6:c.2027G>A 7:g.55174021G>A EGFR ENST00000275493.6 3633 3236 2345355 2345355 2210027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637138 1637138 1553186 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2078464 2078464 1957183 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV104577168 COSM9361242 132613109 c.2249T>G p.F750C Substitution - Missense het 38 7:55181393-55181393 + - PATHOGENIC .74752 Variant of unknown origin 31632838 circulating tumour recurrent 68 ENSP00000395243.3:p.Phe750Cys ENST00000454757.6:c.2249T>G 7:g.55181393T>G EGFR ENST00000275493.6 3633 3236 1429330 1429330 1338781 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51806057 COSM41603 99415829 c.2134T>C p.F712L Substitution - Missense 38 7:55173993-55173993 + - PATHOGENIC .92149 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Phe712Leu ENST00000275493.6:c.2134T>C 7:g.55173993T>C EGFR ENST00000275493.6 3633 3236 1481228 1481228 1404857 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895165 1895165 1783857 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2136672 2136672 2006223 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1074914 1074914 990168 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17508947 surgery fresh/frozen primary 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2239181 2239181 2106713 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 50 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2239181 2239181 2106713 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 50 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345049 2345049 2209721 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2105821 2105821 1983859 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2865568 2865568 2720698 lung NS NS NS carcinoma adenocarcinoma transformed_to_small_cell_carcinoma NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29120087 surgery-fixed recurrent 52 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602806 1602806 1522142 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429330 1429330 1338781 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51806057 COSM41603 133241556 c.1999T>C p.F667L Substitution - Missense 38 7:55173993-55173993 + - PATHOGENIC .92149 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Phe667Leu ENST00000455089.5:c.1999T>C 7:g.55173993T>C EGFR ENST00000275493.6 3633 3236 2344946 2344946 2209618 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25674250 NS NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1201380 1201380 1113270 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 19357847 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 1895089 1895089 1783781 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891251 1891251 1780620 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239181 2239181 2106713 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 50 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239181 2239181 2106713 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 50 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1738959 1738959 1644790 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1475398 1475398 1399097 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665699 2665699 2525408 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS primary 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 914814 914814 832263 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469860 1469860 1393599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469860 1469860 1393599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1074944 1074944 990198 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2865245 2865245 2720375 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29413048 surgery-fixed primary 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2809832 2809832 2666499 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31315676 cerebrospinal fluid NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637102 1637102 1553150 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2701162 2701162 2560066 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51822289 COSM42977 99402277 c.315G>T p.Q105H Substitution - Missense het 38 7:55143379-55143379 + - PATHOGENIC .90579 Reported in another cancer sample as somatic 28581676 surgery-fixed NS 41 ENSP00000275493.2:p.Gln105His ENST00000275493.6:c.315G>T 7:g.55143379G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1738959 1738959 1644790 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914814 914814 832263 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1074944 1074944 990198 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2029015 2029015 1910897 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2350428 2350428 2214799 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23357969 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469809 1469809 1393548 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1098815 1098815 1013407 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765252 COSM13009 99400543 c.2126A>G p.E709G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Glu709Gly ENST00000275493.6:c.2126A>G 7:g.55173985A>G EGFR ENST00000275493.6 3633 3236 1098815 1098815 1013407 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1444732 1444732 1368975 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345061 2345061 2209733 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778594 2778594 2636648 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51784752 COSM13199 133204015 c.2483G>A p.G828E Substitution - Missense 38 7:55191867-55191867 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000415559.1:p.Gly828Glu ENST00000455089.5:c.2483G>A 7:g.55191867G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1160959 1160959 1073295 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 19002495 surgery-fixed primary 62 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1469430 1469430 1393169 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637628 2637628 2498001 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 67 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2226901 2226901 2094636 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1498642 1498642 1421520 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21315472 surgery - NOS metastasis 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1895133 1895133 1783825 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1874746 1874746 1765337 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042855 1042855 959196 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098815 1098815 1013407 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098815 1098815 1013407 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765252 COSM13009 133225791 c.1991A>G p.E664G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Glu664Gly ENST00000455089.5:c.1991A>G 7:g.55173985A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924511 924511 841284 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1098875 1098875 1013467 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 924511 924511 841284 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618855 1618855 1537607 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 60 ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895089 1895089 1783781 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891251 1891251 1780620 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226898 2226898 2094633 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SK-MEL-28 2651877 2512016 NS NS NS NS malignant_melanoma NS NS NS n COSV51778029 COSM6268 133209348 c.2122C>T p.P708S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 24336498 cell-line NS ENSP00000415559.1:p.Pro708Ser ENST00000455089.5:c.2122C>T 7:g.55174794C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226901 2226901 2094636 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226898 2226898 2094633 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1774688 1774688 1678912 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22993320 surgery - NOS recurrent 70 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 921162 921162 838121 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16002952 surgery-fixed primary 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2032063 2032063 1913534 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24103528 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983130 983130 898848 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637633 2637633 2498006 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 surgery - NOS primary 81 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1835514 1835514 1730546 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23242440 NS NS 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1295350 1295350 1206429 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19884551 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2026259 2026259 1908348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895133 1895133 1783825 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891319 1891319 1780688 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1295350 1295350 1206429 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19884551 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00354T00354 2857354 2712654 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2474453 2474453 2337222 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 NPC0002PT00013T00013 2857370 2712670 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV99291226 COSM7552389 99405137 c.1124C>T p.A375V Substitution - Missense 38 7:55156650-55156650 + - PATHOGENIC .98971 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Ala375Val ENST00000275493.6:c.1124C>T 7:g.55156650C>T EGFR ENST00000275493.6 3633 3236 1891319 1891319 1780688 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1469511 1469511 1393250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 NPC0001PT00354T00354 2857354 2712654 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1235127 1235127 1146913 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 55 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1618879 1618879 1537631 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 22209037 surgery-fixed primary 68 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2785991 2785991 2643451 large_intestine colon right NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 27586204 NS NS 91 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2167082 2167082 2035396 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51782791 COSM3736992 132549963 c.2171T>C p.V724A Substitution - Missense het 38 7:55181315-55181315 + - PATHOGENIC .97686 Variant of unknown origin 24908064 surgery - NOS NS 58 ENSP00000395243.3:p.Val724Ala ENST00000454757.6:c.2171T>C 7:g.55181315T>C EGFR ENST00000275493.6 3633 3236 2841124 2841124 2696684 prostate NS NS NS carcinoma NS NS NS n COSV51806557 COSM6919399 99426383 c.2795G>A p.R932H Substitution - Missense 38 7:55198810-55198810 + - PATHOGENIC .99081 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000275493.2:p.Arg932His ENST00000275493.6:c.2795G>A 7:g.55198810G>A EGFR ENST00000275493.6 3633 3236 1329262 1329262 1239747 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2089573 2089573 1967782 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24511003 surgery fresh/frozen NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008802 2008802 1891536 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008802 2008802 1891536 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM28739 178379146 c.? p.D761Y Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Asp761Tyr EGFR ENST00000275493.6 3633 3236 2095910 2095910 1973974 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425781 2425781 2288702 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2855910 2855910 2711313 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV104368998 COSM9232920 133219743 c.751C>T p.P251S Substitution - Missense 38 7:55154149-55154149 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 32269842 surgery-fixed NS 58 ENSP00000415559.1:p.Pro251Ser ENST00000455089.5:c.751C>T 7:g.55154149C>T EGFR ENST00000275493.6 3633 3236 1108052 1108052 1021955 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 17973572 surgery - NOS recurrent 71 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1351218 1351218 1261457 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 20107421 surgery - NOS NS 78 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1774670 1774670 1678894 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22993320 pleural effusion recurrent 65 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2105827 2105827 1983865 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2141402 2141402 2010643 lung right_middle_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24636847 fine needle aspirate recurrent 57 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2485109 2485109 2347809 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 20630828 NS recurrent 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618718 1618718 1537470 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 57 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1531007 1531007 1453379 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264422 2264422 2131406 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1542179 1542179 1464482 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1585368 1585368 1506689 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22011666 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618754 1618754 1537506 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 58 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1246731 1246731 1158410 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914817 914817 832266 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077344 1077344 992598 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1714998 1714998 1622577 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22710815 surgery-fixed primary 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2153117 2153117 2022127 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1875696 1875696 1766279 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770601 1770601 1674841 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891182 1891182 1780551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983719 1983719 1869955 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891286 1891286 1780655 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891218 1891218 1780587 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1627726 1627726 1544638 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372594 2372594 2235387 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1083994 1083994 999159 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17785547 surgery fresh/frozen primary 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450922 1450922 1375065 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 52 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983785 1983785 1870021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895072 1895072 1783764 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983761 1983761 1869997 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 HCC827CLR 1604992 1524306 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 22133747 cell-line NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891328 1891328 1780697 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879569 1879569 1770071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891322 1891322 1780691 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2555800 2555800 2417237 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26599269 surgery - NOS NS 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899337 899337 816949 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077331 1077331 992585 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593009 1593009 1513935 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450940 1450940 1375083 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891194 1891194 1780563 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098857 1098857 1013449 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1627723 1627723 1544635 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983759 1983759 1869995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899333 899333 816945 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2701162 2701162 2560066 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51822289 COSM42977 133227861 c.315G>T p.Q105H Substitution - Missense het 38 7:55143379-55143379 + - PATHOGENIC .90579 Reported in another cancer sample as somatic 28581676 surgery-fixed NS 41 ENSP00000415559.1:p.Gln105His ENST00000455089.5:c.315G>T 7:g.55143379G>T EGFR ENST00000275493.6 3633 3236 2228289 2228289 2096012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637156 1637156 1553204 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246655 1246655 1158334 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895072 1895072 1783764 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2047766 2047766 1928038 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1078226 1078226 993476 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 17626639 surgery-fixed metastasis ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1102406 1102406 1016658 lung right_upper_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18208799 surgery-fixed primary 47 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-67-3772-01 1780202 1684201 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 82 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 914817 914817 832266 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2076974 2076974 1955723 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed metastasis 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664335 2664335 2524410 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 63 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 916973 916973 834354 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16052537 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 916968 916968 834349 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16052537 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525712 2525712 2387900 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1042855 1042855 959196 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51780730 COSM22940 99378223 c.2327G>A p.R776H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Arg776His ENST00000275493.6:c.2327G>A 7:g.55181336G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453490 1453490 1377523 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-78-7147-01 1914054 1802336 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 67 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-02-0003-01 1910122 1798413 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51809225 COSM35825 133233661 c.1724G>A p.C575Y Substitution - Missense het 38 7:55165416-55165416 + - PATHOGENIC .99893 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 50 ENSP00000415559.1:p.Cys575Tyr ENST00000455089.5:c.1724G>A 7:g.55165416G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136893 1136893 1049457 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862076 2862076 2717282 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 32122695 surgery - NOS metastasis 62 ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862076 2862076 2717282 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 32122695 surgery - NOS metastasis 62 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1330078 1330078 1240563 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51847775 COSM41663 132570105 c.2327T>C p.I776T Substitution - Missense het 38 7:55181471-55181471 + - PATHOGENIC .92352 Variant of unknown origin 20208477 surgery - NOS NS ENSP00000395243.3:p.Ile776Thr ENST00000454757.6:c.2327T>C 7:g.55181471T>C EGFR ENST00000275493.6 3633 3236 2686023 2686023 2545058 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2096305 2096305 1974369 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1638732 1638732 1554731 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1110729 1110729 1024607 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18325048 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965871 1965871 1852364 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422927 2422927 2285849 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2007098 2007098 1889979 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23790173 surgery-fixed NS 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1075798 1075798 991052 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17575133 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770574 1770574 1674814 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1154302 1154302 1066638 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18957054 surgery-fixed NS 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105807 2105807 1983845 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549133 2549133 2410588 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680482 2680482 2539755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1892632 1892632 1781884 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23566546 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2241826 2241826 2109357 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25228365 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1696876 1696876 1605004 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22674612 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1526340 1526340 1448709 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21622546 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665711 2665711 2525420 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS primary 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1610413 1610413 1529653 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22142557 pleural effusion NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2141402 2141402 2010643 lung right_middle_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24636847 fine needle aspirate recurrent 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095950 2095950 1974014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638744 1638744 1554743 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874661 1874661 1765252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246675 1246675 1158354 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0002PT00039T00039 2857325 2712625 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-147-tumor 2819052 2675351 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1770722 1770722 1674962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1467314 1467314 1391160 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20940188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2485109 2485109 2347809 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20630828 NS recurrent 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264244 2264244 2131228 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2156992 2156992 2025967 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264237 2264237 2131221 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214550 2214550 2082674 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264253 2264253 2131237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264174 2264174 2131158 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1465901 1465901 1389748 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734165 1734165 1640114 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22843912 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246705 1246705 1158384 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966254 1966254 1852747 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23800712 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2238944 2238944 2106476 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25137181 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774690 1774690 1678914 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS metastasis 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106560 2106560 1984423 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618718 1618718 1537470 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914937 1914937 1802939 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264290 2264290 2131274 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838719 1838719 1732820 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1162984 1162984 1075307 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18992959 NS primary 45 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1531007 1531007 1453379 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591032 1591032 1512148 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240662 2240662 2108193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2069156 2069156 1948731 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24346091 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965849 1965849 1852342 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014240 1014240 931414 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fresh/frozen - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887388 1887388 1777060 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421213 2421213 2284135 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218529 2218529 2086540 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000259 2000259 1885157 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011189 2011189 1893827 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 916967 916967 834348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16052537 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083794 1083794 998959 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2686023 2686023 2545058 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587263 1587263 1508434 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618754 1618754 1537506 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965272 1965272 1851767 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23803047 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246620 1246620 1158299 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964307 1964307 1850842 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770549 1770549 1674789 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451757 1451757 1375806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20615575 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425753 2425753 2288674 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264154 2264154 2131138 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1664610 1664610 1578060 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21899495 pleural effusion NS 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246702 1246702 1158381 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914946 1914946 1802948 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290960 2290960 2157025 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264268 2264268 2131252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965816 1965816 1852309 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842984 1842984 1736232 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1196960 1196960 1108855 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2585236 2585236 2446400 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSM6009000 178378913 c.? p.G465R Substitution - Missense + - Variant of unknown origin 27929064 surgery - NOS recurrent ENSP00000275493.2:p.Gly465Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067045 1067045 983025 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1075906 1075906 991160 lung NS NS NS other hyperplasia NS NS n COSV51772923 COSM21984 133222251 c.2146G>T p.D716Y Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99554 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000415559.1:p.Asp716Tyr ENST00000455089.5:c.2146G>T 7:g.55174818G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1075906 1075906 991160 lung NS NS NS other hyperplasia NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 109590 2812898 2669312 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 56 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1430039 1430039 1339457 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1877564 1877564 1768125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23408463 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264332 2264332 2131316 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096158 2096158 1974222 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422844 2422844 2285766 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422844 2422844 2285766 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 053 2218436 2086447 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM34167 178379046 c.? p.G598V Substitution - Missense + - Reported in another cancer sample as somatic 25078279 surgery fresh/frozen primary 59 ENSP00000275493.2:p.Gly598Val EGFR ENST00000275493.6 3633 3236 1921946 1921946 1809264 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1671442 1671442 1584644 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22197614 surgery - NOS primary ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2555800 2555800 2417237 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26599269 surgery - NOS NS 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0002PT00013T00013 2857370 2712670 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV99291226 COSM7552389 133231100 c.989C>T p.A330V Substitution - Missense 38 7:55156650-55156650 + - PATHOGENIC .98971 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Ala330Val ENST00000455089.5:c.989C>T 7:g.55156650C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875356 1875356 1765939 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226890 2226890 2094625 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096048 2096048 1974112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096025 2096025 1974089 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937510 1937510 1824444 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1078226 1078226 993476 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 17626639 surgery-fixed metastasis ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2562095 2562095 2423491 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637163 1637163 1553211 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965827 1965827 1852320 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914901 1914901 1802903 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025403 2025403 1907492 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937574 1937574 1824508 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618747 1618747 1537499 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 89 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345411 2345411 2210083 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 999923 999923 917146 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16785471 surgery - NOS primary 82 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2432444 2432444 2295345 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25798276 NS NS 81 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444749 1444749 1368992 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986135 1986135 1872371 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1517868 1517868 1440246 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 21572125 fine needle aspirate NS 83 ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 1517868 1517868 1440246 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21572125 fine needle aspirate NS 83 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1842978 1842978 1736226 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770590 1770590 1674830 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345554 2345554 2210226 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226160 2226160 2093895 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LPS3 2800446 2657262 soft_tissue fat NS NS liposarcoma well_differentiated NS NS n COSV99289299 COSM9110946 132582609 c.1114C>T p.L372F Substitution - Missense 38 7:55157704-55157704 + - PATHOGENIC .98762 Variant of unknown origin 26643872 surgery - NOS primary ENSP00000395243.3:p.Leu372Phe ENST00000454757.6:c.1114C>T 7:g.55157704C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593031 1593031 1513957 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51776171 COSM28605 132591561 c.2476G>A p.A826T Substitution - Missense 38 7:55191860-55191860 + - PATHOGENIC .9853 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000395243.3:p.Ala826Thr ENST00000454757.6:c.2476G>A 7:g.55191860G>A EGFR ENST00000275493.6 3633 3236 1246678 1246678 1158357 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1752343 1752343 1657154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22912354 fixed - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1637090 1637090 1553138 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2350409 2350409 2214780 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 23357969 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1770657 1770657 1674897 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1102406 1102406 1016658 lung right_upper_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18208799 surgery-fixed primary 47 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2778778 2778778 2636832 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 29066915 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1887366 1887366 1777038 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-67-3772-01 1780202 1684201 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 82 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469437 1469437 1393176 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2349274 2349274 2213666 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25654374 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879493 1879493 1769995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1141293 1141293 1053741 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770594 1770594 1674834 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-78-7147-01 1914054 1802336 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 67 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2148516 2148516 2017646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1032006 1032006 948797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17060940 pleural effusion NS 65 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077332 1077332 992586 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302280 1302280 1213331 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1981034 1981034 1867270 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 1981034 1981034 1867270 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1453490 1453490 1377523 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1877568 1877568 1768129 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23408463 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2032253 2032253 1913724 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1838696 1838696 1732797 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921902 1921902 1809220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083353 1083353 998518 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17596643 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1862558 1862558 1753449 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23352033 fine needle aspirate primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1576810 1576810 1498251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21921847 surgery - NOS primary 42 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921733 1921733 1809051 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense hom + - Reported in another cancer sample as somatic 23620765 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1610414 1610414 1529654 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22142557 pleural effusion NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547808 1547808 1469930 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 fine needle aspirate recurrent 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402479 2402479 2265335 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 66 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1734086 1734086 1640035 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22842370 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875356 1875356 1765939 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1838733 1838733 1732834 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838646 1838646 1732747 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777219 1777219 1681222 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2157024 2157024 2025999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM85997 178378528 c.? p.G719X Substitution - Missense + - Variant of unknown origin 24828666 fixed - NOS NS EGFR ENST00000275493.6 3633 3236 TCGA-02-0003-01 1910122 1798413 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51809225 COSM35825 99407038 c.1859G>A p.C620Y Substitution - Missense het 38 7:55165416-55165416 + - PATHOGENIC .99893 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 50 ENSP00000275493.2:p.Cys620Tyr ENST00000275493.6:c.1859G>A 7:g.55165416G>A EGFR ENST00000275493.6 3633 3236 1136893 1136893 1049457 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264184 2264184 2131168 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862076 2862076 2717282 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 32122695 surgery - NOS metastasis 62 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2862076 2862076 2717282 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 32122695 surgery - NOS metastasis 62 ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 1140933 1140933 1053381 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448998 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875376 1875376 1765959 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-02-0010-01 1910840 1799125 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779590 COSM35427 132608346 c.1903C>G p.R635G Substitution - Missense het 38 7:55173101-55173101 + - PATHOGENIC .98466 Variant of unknown origin 329 fresh/frozen - NOS primary 22 ENSP00000395243.3:p.Arg635Gly ENST00000454757.6:c.1903C>G 7:g.55173101C>G EGFR ENST00000275493.6 3633 3236 1515267 1515267 1437877 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1489670 1489670 1412828 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21155184 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983761 1983761 1869997 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1237685 1237685 1149432 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029017 2029017 1910899 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081908 2081908 1960330 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081908 2081908 1960330 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096142 2096142 1974206 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1517400 1517400 1439784 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21610522 cerebrospinal fluid metastasis 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547768 1547768 1469890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 47 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1881683 1881683 1771834 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23391413 NS metastasis ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043864 1043864 960205 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 K5B66H 2762307 2620566 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51767869 COSM3266583 132551074 c.1216C>T p.R406C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 29615459 NS primary 42 ENSP00000395243.3:p.Arg406Cys ENST00000454757.6:c.1216C>T 7:g.55160191C>T EGFR ENST00000275493.6 3633 3236 1014266 1014266 931440 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549143 2549143 2410598 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1067045 1067045 983025 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2148630 2148630 2017760 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1075906 1075906 991160 lung NS NS NS other hyperplasia NS NS n COSV51772923 COSM21984 99396060 c.2281G>T p.D761Y Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99554 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000275493.2:p.Asp761Tyr ENST00000275493.6:c.2281G>T 7:g.55174818G>T EGFR ENST00000275493.6 3633 3236 1075906 1075906 991160 lung NS NS NS other hyperplasia NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2008786 2008786 1891520 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665700 2665700 2525409 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28978102 ascites recurrent 64 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2665700 2665700 2525409 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 ascites recurrent 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047765 2047765 1928037 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096091 2096091 1974155 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425729 2425729 2288650 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 G1 1063227 979272 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 65 ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 2778594 2778594 2636648 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51784752 COSM13199 99375727 c.2618G>A p.G873E Substitution - Missense 38 7:55191867-55191867 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000275493.2:p.Gly873Glu ENST00000275493.6:c.2618G>A 7:g.55191867G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895121 1895121 1783813 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AP-A051-01 1783330 1687329 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51848796 COSM1090874 133216846 c.1186G>A p.V396I Substitution - Missense het 38 7:55160161-55160161 + - PATHOGENIC .92435 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000415559.1:p.Val396Ile ENST00000455089.5:c.1186G>A 7:g.55160161G>A EGFR ENST00000275493.6 3633 3236 1891232 1891232 1780601 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1135415 1135415 1047979 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1089595 1089595 1004542 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 HCC149 2776336 2634472 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29681454 NS NS 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895124 1895124 1783816 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924332 924332 841107 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602798 1602798 1522134 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2057513 2057513 1937720 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24255770 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1549827 1549827 1471932 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1631954 1631954 1548824 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1738902 1738902 1644733 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891280 1891280 1780649 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1000048 1000048 917271 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1594555 1594555 1515523 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1592984 1592984 1513910 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 914815 914815 832264 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 11-18 946048 862574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1931646 1931646 1818936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897834 897834 815456 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1882529 1882529 1772664 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23486266 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2841124 2841124 2696684 prostate NS NS NS carcinoma NS NS NS n COSV51806557 COSM6919399 133250140 c.2660G>A p.R887H Substitution - Missense 38 7:55198810-55198810 + - PATHOGENIC .99081 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000415559.1:p.Arg887His ENST00000455089.5:c.2660G>A 7:g.55198810G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1876999 1876999 1767561 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042912 1042912 959253 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226890 2226890 2094625 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1202551 1202551 1114437 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983723 1983723 1869959 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983769 1983769 1870005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983720 1983720 1869956 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 G22 1063236 979281 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 896919 896919 814542 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15329413 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1038992 1038992 955569 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862727 2862727 2717890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1434016 1434016 1343431 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1594597 1594597 1515565 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1627729 1627729 1544641 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895080 1895080 1783772 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899324 899324 816936 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895065 1895065 1783757 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 MG-147-tumor 2819052 2675351 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732921 2732921 2591674 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 49 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 1676424 1676424 1589192 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422924 2422924 2285846 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081818 2081818 1960240 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481317 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422929 2422929 2285851 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875376 1875376 1765959 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1355114 1355114 1265209 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-18-K35709 2905399 2759655 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51847987 COSM4384128 133214675 c.2731G>A p.D911N Substitution - Missense 38 7:55200333-55200333 + - PATHOGENIC .99504 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Asp911Asn ENST00000455089.5:c.2731G>A 7:g.55200333G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043859 1043859 960200 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2508973 2508973 2371308 central_nervous_system temporal_lobe NS NS glioma oligoastrocytoma_Grade_II NS NS n COSV51823792 COSM5762244 132621709 c.2749C>T p.R917C Substitution - Missense 38 7:55200351-55200351 + - PATHOGENIC .96304 Variant of unknown origin 26919320 surgery - NOS NS 32 ENSP00000395243.3:p.Arg917Cys ENST00000454757.6:c.2749C>T 7:g.55200351C>T EGFR ENST00000275493.6 3633 3236 2675370 2675370 2534644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51794784 COSM13182 99375617 c.2203G>A p.G735S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Gly735Ser ENST00000275493.6:c.2203G>A 7:g.55174740G>A EGFR ENST00000275493.6 3633 3236 BL-16-G30012 2905599 2759855 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51815598 COSM6471954 99393578 c.1325G>T p.S442I Substitution - Missense 38 7:55160165-55160165 + - NEUTRAL .44157 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Ser442Ile ENST00000275493.6:c.1325G>T 7:g.55160165G>T EGFR ENST00000275493.6 3633 3236 2131895 2131895 2005959 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419415 NS NS 68 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2096143 2096143 1974207 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1876999 1876999 1767561 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1815282 1815282 1714453 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22896669 surgery - NOS metastasis 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1567513 1567513 1489145 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21949883 fine needle aspirate metastasis ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1014317 1014317 931491 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777405 1777405 1681408 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895121 1895121 1783813 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067077 1067077 983057 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1054393 1054393 970464 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618879 1618879 1537631 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 22209037 surgery-fixed primary 68 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2785991 2785991 2643451 large_intestine colon right NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 27586204 NS NS 91 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 109590 2812898 2669312 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 56 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51803429 COSM7002279 99384811 c.1280G>A p.R427H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000275493.2:p.Arg427His ENST00000275493.6:c.1280G>A 7:g.55157735G>A EGFR ENST00000275493.6 3633 3236 24 1077323 992577 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479946 1479946 1403606 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136861 1136861 1049425 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2878966 2878966 2733481 oesophagus NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51813913 COSM6023901 133211053 c.344A>C p.N115T Substitution - Missense 38 7:55143408-55143408 + - PATHOGENIC .92454 Reported in another cancer sample as somatic 33115932 surgery-fixed NS 68 ENSP00000415559.1:p.Asn115Thr ENST00000455089.5:c.344A>C 7:g.55143408A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 19 2570191 2431488 skin face NS NS adnexal_tumour other sebaceoma NS n COSV51828195 COSM13180 132573740 c.2053C>T p.L685F Substitution - Missense 38 7:55174725-55174725 + - PATHOGENIC .96849 Variant of unknown origin 27311873 surgery-fixed NS 71 ENSP00000395243.3:p.Leu685Phe ENST00000454757.6:c.2053C>T 7:g.55174725C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 3696 915973 833372 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51828195 COSM13180 132573740 c.2053C>T p.L685F Substitution - Missense 38 7:55174725-55174725 + - PATHOGENIC .96849 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000395243.3:p.Leu685Phe ENST00000454757.6:c.2053C>T 7:g.55174725C>T EGFR ENST00000275493.6 3633 3236 2281 1188091 1099990 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19235531 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1429298 1429298 1338749 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891193 1891193 1780562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1990916 1990916 1876251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983722 1983722 1869958 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1884155 1884155 1774042 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1089601 1089601 1004548 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862732 2862732 2717895 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042912 1042912 959253 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1551564 1551564 1473669 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1551564 1551564 1473669 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983782 1983782 1870018 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875380 1875380 1765963 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983824 1983824 1870060 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990900 1990900 1876235 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1715002 1715002 1622581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22710815 surgery-fixed metastasis 69 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-66-2742-01 1782475 1686474 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 418 fresh/frozen - NOS primary 70 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2732921 2732921 2591674 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 49 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 1937527 1937527 1824461 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240541 2240541 2108072 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25227801 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637179 1637179 1553227 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046070 2046070 1926365 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042859 1042859 959200 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042859 1042859 959200 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009140 2009140 1891874 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067063 1067063 983043 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1456580 1456580 1380555 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1914938 1914938 1802940 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983782 1983782 1870018 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 983113 983113 898831 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 921164 921164 838123 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16002952 surgery-fixed primary 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637226 1637226 1553274 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045963 2045963 1926258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983167 983167 898885 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549130 2549130 2410585 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770556 1770556 1674796 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2027351 2027351 1909419 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 40 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875378 1875378 1765961 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1235127 1235127 1146913 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 55 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2819295 2819295 2675594 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM24429 178380423 c.? p.E709G Substitution - Missense + - Reported in another cancer sample as somatic 30711944 pleural effusion recurrent 63 ENSP00000275493.2:p.Glu709Gly EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453429 1453429 1377462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 983110 983110 898828 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1043859 1043859 960200 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345475 2345475 2210147 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336869 1336869 1247254 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2136671 2136671 2006222 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1067077 1067077 983057 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1054393 1054393 970464 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1479946 1479946 1403606 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1083070 1083070 998235 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17685931 surgery-fixed NS 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203095 2203095 2071353 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1136861 1136861 1049425 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891210 1891210 1780579 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096215 2096215 1974279 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1715002 1715002 1622581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22710815 surgery-fixed metastasis 69 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 TCGA-66-2742-01 1782475 1686474 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 418 fresh/frozen - NOS primary 70 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594553 1594553 1515521 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51793030 COSM133566 133238435 c.2372G>A p.R791H Substitution - Missense 38 7:55191756-55191756 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000415559.1:p.Arg791His ENST00000455089.5:c.2372G>A 7:g.55191756G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675370 2675370 2534644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51794784 COSM13182 133203905 c.2068G>A p.G690S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000415559.1:p.Gly690Ser ENST00000455089.5:c.2068G>A 7:g.55174740G>A EGFR ENST00000275493.6 3633 3236 1875380 1875380 1765963 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983824 1983824 1870060 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1887400 1887400 1777072 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096223 2096223 1974287 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1275461 1275461 1186759 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19755773 surgery - NOS primary 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1990900 1990900 1876235 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879569 1879569 1770071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 HCC827CLR 1604992 1524306 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 22133747 cell-line NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1891322 1891322 1780691 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1891328 1891328 1780697 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1042859 1042859 959200 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891168 1891168 1780537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899347 899347 816959 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009143 2009143 1891877 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042859 1042859 959200 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2136666 2136666 2006217 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637115 1637115 1553163 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 19 2773123 2631300 skin shoulder NS NS other seborrhoeic_keratosis acanthotic NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23739246 surgery fresh/frozen NS 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2878966 2878966 2733481 oesophagus NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51813913 COSM6023901 99382436 c.344A>C p.N115T Substitution - Missense 38 7:55143408-55143408 + - PATHOGENIC .92454 Reported in another cancer sample as somatic 33115932 surgery-fixed NS 68 ENSP00000275493.2:p.Asn115Thr ENST00000275493.6:c.344A>C 7:g.55143408A>C EGFR ENST00000275493.6 3633 3236 1676422 1676422 1589190 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096109 2096109 1974173 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469782 1469782 1393521 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1453429 1453429 1377462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 H820 2776289 2634425 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29681454 NS NS 53 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1992095 1992095 1877412 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow NS 53 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1992088 1992088 1877405 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 50 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891325 1891325 1780694 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879496 1879496 1769998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2644119 2644119 2504406 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118440 2118440 1992675 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264350 2264350 2131334 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618769 1618769 1537521 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2729134 2729134 2587945 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29368620 fixed - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2729134 2729134 2587945 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29368620 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2009140 2009140 1891874 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2651878 2651878 2512016 NS NS NS NS malignant_melanoma NS NS NS n COSV51778029 COSM6268 132554063 c.2122C>T p.P708S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 24336498 xenograft NS ENSP00000395243.3:p.Pro708Ser ENST00000454757.6:c.2122C>T 7:g.55174794C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PC-9-GR-step 1896428 1785118 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23542356 cell-line NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879541 1879541 1770043 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1067063 1067063 983043 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1246641 1246641 1158320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2157000 2157000 2025975 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118477 2118477 1992712 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2476900 2476900 2339669 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2096206 2096206 1974270 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1981030 1981030 1867266 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1122185 1122185 1035229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 18418018 surgery - NOS NS 51 ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51803429 COSM7002279 133213353 c.1145G>A p.R382H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000415559.1:p.Arg382His ENST00000455089.5:c.1145G>A 7:g.55157735G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862724 2862724 2717887 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226766 2226766 2094501 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1876996 1876996 1767558 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-NYU704 1765133 1669453 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 55 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592879 1592879 1513805 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592879 1592879 1513805 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 1098818 1098818 1013410 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51851382 COSM26437 99390533 c.2567T>C p.F856S Substitution - Missense 38 7:55191816-55191816 + - PATHOGENIC .97798 Variant of unknown origin 18176089 surgery fresh/frozen primary 50 ENSP00000275493.2:p.Phe856Ser ENST00000275493.6:c.2567T>C 7:g.55191816T>C EGFR ENST00000275493.6 3633 3236 1777425 1777425 1681428 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891168 1891168 1780537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CT81 1063221 979266 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 39 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895152 1895152 1783844 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1751709 1751709 1656525 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1500177 1500177 1423056 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453497 1453497 1377530 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777420 1777420 1681423 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264324 2264324 2131308 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2271433 2271433 2138061 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25257380 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469358 1469358 1393097 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535023 1535023 1457358 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1498651 1498651 1421529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21315472 surgery - NOS metastasis 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637632 2637632 2498005 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 66 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2637632 2637632 2498005 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542147 1542147 1464450 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045992 2045992 1926287 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345849 2345849 2210521 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891210 1891210 1780579 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077345 1077345 992599 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875373 1875373 1765956 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1881883 1881883 1772034 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2426855 2426855 2289776 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174300 1174300 1086319 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096088 2096088 1974152 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1086852 1086852 1001866 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17848912 blood-bone marrow NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205972 2205972 2074205 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914894 1914894 1802896 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336846 1336846 1247231 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895097 1895097 1783789 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2045991 2045991 1926286 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1594553 1594553 1515521 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51793030 COSM133566 99411956 c.2507G>A p.R836H Substitution - Missense 38 7:55191756-55191756 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000275493.2:p.Arg836His ENST00000275493.6:c.2507G>A 7:g.55191756G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2770729 2770729 2628930 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25403583 surgery-fixed recurrent 43 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1310470 1310470 1221415 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264301 2264301 2131285 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 899347 899347 816959 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862724 2862724 2717887 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2118435 2118435 1992670 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637178 1637178 1553226 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011179 2011179 1893817 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2095936 2095936 1974000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1576795 1576795 1498236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 surgery - NOS metastasis 86 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1965821 1965821 1852314 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422936 2422936 2285858 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891308 1891308 1780677 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098875 1098875 1013467 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 19 2773123 2631300 skin shoulder NS NS other seborrhoeic_keratosis acanthotic NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23739246 surgery fresh/frozen NS 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2349252 2349252 2213644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25654374 surgery-fixed primary 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279049 1279049 1190345 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed metastasis 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329246 1329246 1239731 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096059 2096059 1974123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000234 2000234 1885132 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731387 1731387 1637353 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22457323 NS NS 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1075007 1075007 990261 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 73 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891217 1891217 1780586 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875353 1875353 1765936 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450928 1450928 1375071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 50 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450857 1450857 1375000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 81 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592979 1592979 1513905 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51779734 COSM133203 133215950 c.2270T>C p.V757A Substitution - Missense 38 7:55181414-55181414 + - PATHOGENIC .95834 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Val757Ala ENST00000455089.5:c.2270T>C 7:g.55181414T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2062141 2062141 1942220 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51850053 COSM1717823 132571268 c.2450T>G p.L817R Substitution - Missense het 38 7:55191834-55191834 + - PATHOGENIC .98155 Variant of unknown origin 24279718 surgery-fixed recurrent 61 ENSP00000395243.3:p.Leu817Arg ENST00000454757.6:c.2450T>G 7:g.55191834T>G EGFR ENST00000275493.6 3633 3236 2260322 2260322 2127307 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25263855 fine needle aspirate NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1885189 1885189 1775076 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549151 2549151 2410606 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 12 2570180 2431477 skin neck NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51798694 COSM18419 99453865 c.2200G>A p.E734K Substitution - Missense 38 7:55174737-55174737 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 60 ENSP00000275493.2:p.Glu734Lys ENST00000275493.6:c.2200G>A 7:g.55174737G>A EGFR ENST00000275493.6 3633 3236 2664330 2664330 2524407 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 32 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2664330 2664330 2524407 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 32 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777234 1777234 1681237 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1945218 1945218 1832128 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51767379 COSM85894 133213549 c.2392G>A p.V798I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 23295441 surgery-fixed NS ENSP00000415559.1:p.Val798Ile ENST00000455089.5:c.2392G>A 7:g.55191776G>A EGFR ENST00000275493.6 3633 3236 2226766 2226766 2094501 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2047750 2047750 1928022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed primary 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1876996 1876996 1767558 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LUAD-NYU704 1765133 1669453 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 55 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1592879 1592879 1513805 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 1592879 1592879 1513805 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469443 1469443 1393182 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000213 2000213 1885111 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095886 2095886 1973950 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046651 2046651 1926945 lung NS NS NS carcinoma NS NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895077 1895077 1783769 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239176 2239176 2106708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51778029 COSM6268 133209348 c.2122C>T p.P708S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 47 ENSP00000415559.1:p.Pro708Ser ENST00000455089.5:c.2122C>T 7:g.55174794C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2509062 2509062 2371397 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_II pleomorphic_xanthoastrocytoma NS n COSV51822879 COSM4680399 133211230 c.1904G>A p.R635Q Substitution - Missense 38 7:55173102-55173102 + - PATHOGENIC .99814 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 16 ENSP00000415559.1:p.Arg635Gln ENST00000455089.5:c.1904G>A 7:g.55173102G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1052730 1052730 968801 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17368623 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2105832 2105832 1983870 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2105832 2105832 1983870 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345503 2345503 2210175 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264380 2264380 2131364 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1122169 1122169 1035213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 18379370 pleural effusion recurrent 72 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1122169 1122169 1035213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18379370 pleural effusion recurrent 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986160 1986160 1872396 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770732 1770732 1674972 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2273788 2273788 2140348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25300933 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278202 1278202 1189500 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1108050 1108050 1021953 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 17973572 pleural effusion recurrent 74 ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1108050 1108050 1021953 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17973572 pleural effusion recurrent 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064725 2064725 1944802 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CT81 1063221 979266 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 39 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895152 1895152 1783844 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1751709 1751709 1656525 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1601928 1601928 1521416 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22108465 surgery-fixed metastasis 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1077345 1077345 992599 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096021 2096021 1974085 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459508 1459508 1383451 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345395 2345395 2210067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148594 2148594 2017724 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163054 2163054 2031638 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1338232 1338232 1248617 lung right_upper_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20357619 surgery - NOS NS 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921897 1921897 1809215 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468083 1468083 1391929 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS recurrent 93 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1468083 1468083 1391929 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21062933 autopsy - NOS recurrent 93 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879540 1879540 1770042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1676410 1676410 1589178 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875373 1875373 1765956 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LU1868 1775135 1679359 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22948846 xenograft NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LU1868 1775135 1679359 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 22948846 xenograft NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005362 1005362 922574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 77 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1789319 1789319 1692723 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1334747 1334747 1245132 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20401612 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264245 2264245 2131229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346533 2346533 2211196 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983120 983120 898838 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264416 2264416 2131400 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1444784 1444784 1369027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1355117 1355117 1265212 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895097 1895097 1783789 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2406844 2406844 2269724 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 44 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996940 1996940 1882149 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM24429 178380423 c.? p.E709G Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 66 ENSP00000275493.2:p.Glu709Gly EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879535 1879535 1770037 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-NYU1210 1765146 1669466 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264177 2264177 2131161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878858 2878858 2733373 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27368130 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203083 2203083 2071341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345369 2345369 2210041 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2908040 2908040 2762219 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24457237 surgery-fixed NS 62 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1891217 1891217 1780586 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875353 1875353 1765936 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226773 2226773 2094508 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51823614 COSM4170219 99373800 c.2255C>T p.S752F Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98332 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Ser752Phe ENST00000275493.6:c.2255C>T 7:g.55174792C>T EGFR ENST00000275493.6 3633 3236 1459493 1459493 1383436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1875679 1875679 1766262 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173407 1173407 1085491 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891308 1891308 1780677 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983829 1983829 1870065 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899342 899342 816954 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231309 1231309 1143099 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897840 897840 815462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2057512 2057512 1937719 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24255770 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1981032 1981032 1867268 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891176 1891176 1780545 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668524 1668524 1581817 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895134 1895134 1783826 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1575156 1575156 1496597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659811 2659811 2519969 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875382 1875382 1765965 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226883 2226883 2094618 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862718 2862718 2717881 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1549834 1549834 1471939 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983699 1983699 1869935 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983742 1983742 1869978 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067061 1067061 983041 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103754 1103754 1018006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 65 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166430 1166430 1078744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773237 COSM28609 132578163 c.2281A>G p.K761E Substitution - Missense het 38 7:55181425-55181425 + - PATHOGENIC .9712 Variant of unknown origin 16870303 surgery - NOS NS 51 ENSP00000395243.3:p.Lys761Glu ENST00000454757.6:c.2281A>G 7:g.55181425A>G EGFR ENST00000275493.6 3633 3236 2345507 2345507 2210179 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345845 2345845 2210517 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1576795 1576795 1498236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 surgery - NOS metastasis 86 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1777370 1777370 1681373 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106530 2106530 1984393 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476899 2476899 2339668 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2011174 2011174 1893812 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770614 1770614 1674854 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042855 1042855 959196 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51780730 COSM22940 133206317 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Arg731His ENST00000455089.5:c.2192G>A 7:g.55181336G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897812 897812 815434 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1024772 1024772 941749 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17020982 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264150 2264150 2131134 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1450928 1450928 1375071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 50 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450857 1450857 1375000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 81 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2675404 2675404 2534678 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-273-tumor 2819121 2675420 meninges NS NS NS meningioma anaplastic NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00320T00320 2857338 2712638 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1592979 1592979 1513905 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51779734 COSM133203 99387809 c.2405T>C p.V802A Substitution - Missense 38 7:55181414-55181414 + - PATHOGENIC .95834 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Val802Ala ENST00000275493.6:c.2405T>C 7:g.55181414T>C EGFR ENST00000275493.6 3633 3236 2345799 2345799 2210471 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1668659 1668659 1581951 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22523351 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422935 2422935 2285857 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1038998 1038998 955575 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1991296 1991296 1876631 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 11 1433976 1343391 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 81 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1197354 1197354 1109249 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 G1 1063227 979272 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 65 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1500178 1500178 1423057 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983750 1983750 1869986 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891205 1891205 1780574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2239179 2239179 2106711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895150 1895150 1783842 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1631950 1631950 1548820 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983826 1983826 1870062 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453431 1453431 1377464 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1816949 1816949 1716117 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1631960 1631960 1548830 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983835 1983835 1870071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1714999 1714999 1622578 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22710815 surgery-fixed metastasis 71 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891204 1891204 1780573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891178 1891178 1780547 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 NPC0002PT00039T00039 2857325 2712625 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1042855 1042855 959196 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1160959 1160959 1073295 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 19002495 surgery-fixed primary 62 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2538973 2538973 2400568 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 99377339 c.2239_2240delinsCC p.L747P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 27499993 circulating tumour NS 61 ENSP00000275493.2:p.Leu747Pro ENST00000275493.6:c.2239_2240delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-14-K41007 2905606 2759862 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089606 1089606 1004553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 2770729 2770729 2628930 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25403583 surgery-fixed recurrent 43 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1310470 1310470 1221415 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1885180 1885180 1775067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593021 1593021 1513947 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879496 1879496 1769998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 H820 2776289 2634425 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29681454 NS NS 53 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1891325 1891325 1780694 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1992095 1992095 1877412 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow NS 53 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1992088 1992088 1877405 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 50 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2000062 2000062 1884960 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS 58 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2000062 2000062 1884960 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS 58 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2095915 2095915 1973979 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1516783 1516783 1439377 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21575212 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2477017 2477017 2339786 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25355724 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2032224 2032224 1913695 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1696868 1696868 1604996 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22674612 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290947 2290947 2157012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 1467297 1467297 1391143 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20940188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2439527 2439527 2302367 lung NS NS NS carcinoma invasive_mucinous_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24119562 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025395 2025395 1907484 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179658 1179658 1091620 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 132563558 c.2239C>T p.L747F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000395243.3:p.Leu747Phe ENST00000454757.6:c.2239C>T 7:g.55181383C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51832120 COSM6493935 132583974 c.2251G>C p.G751R Substitution - Missense 38 7:55181395-55181395 + Yes PATHOGENIC .98511 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000395243.3:p.Gly751Arg ENST00000454757.6:c.2251G>C 7:g.55181395G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51832145 COSM6493936 132574809 c.2254T>G p.C752G Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95801 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000395243.3:p.Cys752Gly ENST00000454757.6:c.2254T>G 7:g.55181398T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2840788 2840788 2696348 prostate NS NS NS carcinoma NS NS NS n COSV51807481 COSM1716255 132553158 c.2017C>A p.L673M Substitution - Missense 38 7:55174011-55174011 + - PATHOGENIC .91907 Variant of unknown origin 31874108 surgery-fixed metastasis ENSP00000395243.3:p.Leu673Met ENST00000454757.6:c.2017C>A 7:g.55174011C>A EGFR ENST00000275493.6 3633 3236 1878636 1878636 1769197 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23407566 surgery - NOS recurrent 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1075006 1075006 990260 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 26 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862264 2862264 2717454 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25969368 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264180 2264180 2131164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766880 COSM28516 132563580 c.2269G>T p.V757F Substitution - Missense 38 7:55181413-55181413 + - PATHOGENIC .89385 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000395243.3:p.Val757Phe ENST00000454757.6:c.2269G>T 7:g.55181413G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 132560202 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 132563564 c.2240T>A p.L747H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000395243.3:p.Leu747His ENST00000454757.6:c.2240T>A 7:g.55181384T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 132563575 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2255G>C 7:g.55181399G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2644799 2644799 2505086 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51770694 COSM20891 132562677 c.2251G>A p.G751S Substitution - Missense 38 7:55181395-55181395 + Yes PATHOGENIC .98244 Reported in another cancer sample as somatic 28625641 circulating tumour recurrent 69 ENSP00000395243.3:p.Gly751Ser ENST00000454757.6:c.2251G>A 7:g.55181395G>A EGFR ENST00000275493.6 3633 3236 1052730 1052730 968801 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17368623 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2560125 2560125 2421549 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26826182 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656980 1656980 1571635 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22338650 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549126 2549126 2410581 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422798 2422798 2285720 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345045 2345045 2209717 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2136617 2136617 2006168 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS 79 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345098 2345098 2209770 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1882245 1882245 1772396 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23392229 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618681 1618681 1537433 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474441 2474441 2337210 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965873 1965873 1852366 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469484 1469484 1393223 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 924451 924451 841226 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16198442 surgery - NOS recurrent 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345505 2345505 2210177 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895077 1895077 1783769 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1246696 1246696 1158375 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914924 1914924 1802926 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2064725 2064725 1944802 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1515247 1515247 1437857 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-M17595 2905164 2759420 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51845233 COSM3734669 133208259 c.2083A>G p.I695V Substitution - Missense 38 7:55174755-55174755 + - PATHOGENIC .99591 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Ile695Val ENST00000455089.5:c.2083A>G 7:g.55174755A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471803 1471803 1395541 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51827262 COSM53226 133217545 c.1964A>G p.N655S Substitution - Missense 38 7:55173958-55173958 + - PATHOGENIC .97158 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000415559.1:p.Asn655Ser ENST00000455089.5:c.1964A>G 7:g.55173958A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2007937 2007937 1890672 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23907151 fine needle aspirate metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077369 1077369 992623 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 2029014 2029014 1910896 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1108050 1108050 1021953 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 17973572 pleural effusion recurrent 74 ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 1108050 1108050 1021953 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17973572 pleural effusion recurrent 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264134 2264134 2131118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346523 2346523 2211186 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549122 2549122 2410577 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881906 1881906 1772057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402485 2402485 2265341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 32 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2026266 2026266 1908355 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770670 1770670 1674910 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 LU1868 1775135 1679359 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22948846 xenograft NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LU1868 1775135 1679359 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 22948846 xenograft NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239167 2239167 2106699 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 35 ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-18-K38789 2905357 2759613 gastrointestinal_tract_(site_indeterminate) NS NS NS carcinoma NS NS NS n COSV51816692 COSM6503372 133234498 c.2905G>A p.D969N Substitution - Missense 38 7:55201281-55201281 + - PATHOGENIC .99528 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000415559.1:p.Asp969Asn ENST00000455089.5:c.2905G>A 7:g.55201281G>A EGFR ENST00000275493.6 3633 3236 2076942 2076942 1955691 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24369725 surgery-fixed recurrent 73 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2824225 2824225 2680044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 31542322 circulating tumour recurrent 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746659 1746659 1651635 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 71 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 NCI-H1975 1028949 945820 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 17145836 cell-line NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264427 2264427 2131411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2476900 2476900 2339669 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2637624 2637624 2497997 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 67 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2603062 2603062 2463953 NS NS NS NS carcinoma adenocarcinoma of_unknown_primary NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 26182302 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1705521 1705521 1613427 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264424 2264424 2131408 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2148633 2148633 2017763 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032242 2032242 1913713 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1896945 1896945 1785632 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 23542356 surgery-fixed recurrent 52 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2105828 2105828 1983866 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2076936 2076936 1955685 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24369725 surgery-fixed metastasis 40 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1246725 1246725 1158404 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2465699 2465699 2328530 lung left NS NS carcinoma adenocarcinoma transformed_to_squamous_cell_carcinoma NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26746366 surgery - NOS recurrent 74 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2729133 2729133 2587944 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29368620 fixed - NOS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860432 1860432 1751373 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1734963 1734963 1640907 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 49 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668543 1668543 1581836 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226905 2226905 2094640 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875339 1875339 1765922 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924348 924348 841123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1135418 1135418 1047982 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895149 1895149 1783841 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895088 1895088 1783780 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1197367 1197367 1109262 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1435996 1435996 1345275 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen NS 59 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231323 1231323 1143113 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136864 1136864 1049428 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226902 2226902 2094637 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891174 1891174 1780543 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1451204 1451204 1375347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1200916 1200916 1112806 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2147914 2147914 2017057 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1107249 1107249 1021161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879540 1879540 1770042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 915735 915735 833134 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 16014894 NS recurrent ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2157005 2157005 2025980 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1991299 1991299 1876634 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1625787 1625787 1543011 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602819 1602819 1522155 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166439 1166439 1078753 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 33 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891236 1891236 1780605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2479710 2479710 2342456 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891233 1891233 1780602 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1837417 1837417 1731616 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 23242437 NS NS 55 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1996547 1996547 1881756 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 23922984 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2264383 2264383 2131367 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2153074 2153074 2022084 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1914900 1914900 1802902 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1435658 1435658 1344937 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20661086 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205970 2205970 2074203 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1881389 1881389 1771540 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-023-tumor 2818984 2675283 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-208-tumor 2819090 2675389 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862733 2862733 2717896 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862733 2862733 2717896 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51796944 COSM28537 133210567 c.2425A>G p.T809A Substitution - Missense 38 7:55191809-55191809 + - PATHOGENIC .9858 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Thr809Ala ENST00000455089.5:c.2425A>G 7:g.55191809A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875337 1875337 1765920 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1937561 1937561 1824495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1005362 1005362 922574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 77 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1515266 1515266 1437876 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2778782 2778782 2636836 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 29066915 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345044 2345044 2209716 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-024-tumor 2818985 2675284 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1881389 1881389 1771540 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 99375713 c.2318A>T p.H773L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000275493.2:p.His773Leu ENST00000275493.6:c.2318A>T 7:g.55181327A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2579678 2579678 2441015 NS NS NS NS malignant_melanoma NS NS NS n COSV51769129 COSM6005742 132567530 c.1666_1667delinsAA p.G556K Substitution - Missense 38 7:55165358-55165359 + - Variant of unknown origin 25148578 surgery-fixed NS ENSP00000395243.3:p.Gly556Lys ENST00000454757.6:c.1666_1667delinsAA 7:g.55165358_55165359delinsAA EGFR ENST00000275493.6 3633 3236 1770615 1770615 1674855 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2595769 2595769 2456645 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2264381 2264381 2131365 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1981032 1981032 1867268 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2345119 2345119 2209791 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1312388 1312388 1223297 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 19723643 surgery fresh/frozen NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000164 2000164 1885062 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076942 2076942 1955691 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed recurrent 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230476 1230476 1142290 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118477 2118477 1992712 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522876 1522876 1445248 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838709 1838709 1732810 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098882 1098882 1013474 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51835641 COSM26436 132610905 c.2399T>C p.V800A Substitution - Missense 38 7:55191783-55191783 + - PATHOGENIC .97813 Variant of unknown origin 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Val800Ala ENST00000454757.6:c.2399T>C 7:g.55191783T>C EGFR ENST00000275493.6 3633 3236 1844341 1844341 1737375 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1113037 1113037 1026538 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18458038 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246652 1246652 1158331 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174317 1174317 1086336 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983165 983165 898883 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777313 1777313 1681316 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008970 2008970 1891704 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23979198 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1097642 1097642 1012303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1746659 1746659 1651635 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1715982 1715982 1623544 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22760226 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000216 2000216 1885114 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937566 1937566 1824500 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 NCI-H1975 1028949 945820 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17145836 cell-line NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2894939 2894939 2749421 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS primary 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345540 2345540 2210212 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469428 1469428 1393167 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770642 1770642 1674882 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345546 2345546 2210218 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475410 1475410 1399109 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965817 1965817 1852310 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469871 1469871 1393610 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264427 2264427 2131411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240660 2240660 2108191 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345502 2345502 2210174 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095925 2095925 1973989 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1486482 1486482 1410100 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21107288 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346488 2346488 2211151 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887377 1887377 1777049 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1534802 1534802 1457139 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21684626 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095972 2095972 1974036 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667713 1667713 1581006 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1816762 1816762 1715930 lung left_upper_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23181703 surgery - NOS NS 39 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475403 1475403 1399102 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345349 2345349 2210021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777296 1777296 1681299 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964329 1964329 1850864 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1112962 1112962 1026473 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448997 surgery-fixed NS 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279052 1279052 1190348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed primary 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476894 2476894 2339663 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637166 1637166 1553214 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205977 2205977 2074210 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1732975 1732975 1638924 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22833420 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476869 2476869 2339638 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842993 1842993 1736241 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264283 2264283 2131267 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777394 1777394 1681397 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2562101 2562101 2423497 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1140941 1140941 1053389 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448998 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469406 1469406 1393145 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148633 2148633 2017763 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937525 1937525 1824459 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549137 2549137 2410592 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345577 2345577 2210249 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095927 2095927 1973991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921725 1921725 1809043 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23620765 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421159 2421159 2284081 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1097648 1097648 1012309 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937573 1937573 1824507 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1517413 1517413 1439797 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21617709 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096056 2096056 1974120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402524 2402524 2265380 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014112 1014112 931286 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1993799 1993799 1879055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23892415 surgery-fixed primary 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1862570 1862570 1753461 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23352033 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 916971 916971 834352 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16052537 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083815 1083815 998980 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2465699 2465699 2328530 lung left NS NS carcinoma adenocarcinoma transformed_to_squamous_cell_carcinoma NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26746366 surgery - NOS recurrent 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421234 2421234 2284156 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1815287 1815287 1714458 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22896669 surgery - NOS NS 89 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914957 1914957 1802959 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591019 1591019 1512135 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264288 2264288 2131272 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1695702 1695702 1603914 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22673630 surgery - NOS NS 47 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2729133 2729133 2587944 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29368620 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226166 2226166 2093901 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425759 2425759 2288680 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469866 1469866 1393605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1963285 1963285 1849833 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23599349 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226854 2226854 2094589 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51787381 COSM22991 132578775 c.2195T>A p.L732Q Substitution - Missense 38 7:55181339-55181339 + - PATHOGENIC .97894 Variant of unknown origin 24891042 NS NS ENSP00000395243.3:p.Leu732Gln ENST00000454757.6:c.2195T>A 7:g.55181339T>A EGFR ENST00000275493.6 3633 3236 1844344 1844344 1737378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1715983 1715983 1623545 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM30754 178378833 c.? p.L747P Substitution - Missense + - Reported in another cancer sample as somatic 22760226 surgery - NOS NS ENSP00000275493.2:p.Leu747Pro EGFR ENST00000275493.6 3633 3236 BL-18-K38789 2905357 2759613 gastrointestinal_tract_(site_indeterminate) NS NS NS carcinoma NS NS NS n COSV51816692 COSM6503372 99407654 c.3040G>A p.D1014N Substitution - Missense 38 7:55201281-55201281 + - PATHOGENIC .99528 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000275493.2:p.Asp1014Asn ENST00000275493.6:c.3040G>A 7:g.55201281G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592873 1592873 1513799 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51790353 COSM13178 132609832 c.1946C>T p.P649L Substitution - Missense 38 7:55173940-55173940 + - PATHOGENIC .97388 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000395243.3:p.Pro649Leu ENST00000454757.6:c.1946C>T 7:g.55173940C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1661390 1661390 1575005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51799102 COSM28513 132559266 c.2215T>C p.S739P Substitution - Missense 38 7:55181359-55181359 + - PATHOGENIC .95834 Variant of unknown origin 22483783 surgery-fixed NS 57 ENSP00000395243.3:p.Ser739Pro ENST00000454757.6:c.2215T>C 7:g.55181359T>C EGFR ENST00000275493.6 3633 3236 1777235 1777235 1681238 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105829 2105829 1983867 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2203098 2203098 2071356 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2486050 2486050 2348699 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 27013585 surgery - NOS primary 57 ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-176-tumor 2819069 2675368 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1789319 1789319 1692723 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469452 1469452 1393191 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879535 1879535 1770037 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2142108 2142108 2011326 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240673 2240673 2108204 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 LUAD-NYU1210 1765146 1669466 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2675417 2675417 2534691 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594126 1594126 1515050 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724887 surgery fresh/frozen NS 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1054392 1054392 970463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1054392 1054392 970463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777782 COSM6227 132554599 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000395243.3:p.His790Leu ENST00000454757.6:c.2369A>T 7:g.55191753A>T EGFR ENST00000275493.6 3633 3236 2659811 2659811 2519969 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1549811 1549811 1471916 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 71 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1981024 1981024 1867260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1530996 1530996 1453368 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000180 2000180 1885078 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479942 1479942 1403602 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089117 1089117 1004071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089117 1089117 1004071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631941 1631941 1548811 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471798 1471798 1395536 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51798278 COSM53224 132593585 c.2038A>G p.T680A Substitution - Missense 38 7:55174032-55174032 + - PATHOGENIC .98345 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000395243.3:p.Thr680Ala ENST00000454757.6:c.2038A>G 7:g.55174032A>G EGFR ENST00000275493.6 3633 3236 1653409 1653409 1568196 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22333630 NS NS 82 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777273 1777273 1681276 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421225 2421225 2284147 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469496 1469496 1393235 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1878637 1878637 1769198 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 23407566 surgery - NOS recurrent 66 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1878637 1878637 1769198 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23407566 surgery - NOS recurrent 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264212 2264212 2131196 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118441 2118441 1992676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218547 2218547 2086558 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1993864 1993864 1879120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23892415 surgery-fixed metastasis 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960192 1960192 1846832 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937591 1937591 1824525 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475412 1475412 1399111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214537 2214537 2082661 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891224 1891224 1780593 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009138 2009138 1891872 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1459521 1459521 1383464 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1989926 1989926 1875265 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1166943 178385114 c.? p.V769L Substitution - Missense + - Reported in another cancer sample as somatic 22973961 surgery - NOS metastasis ENSP00000275493.2:p.Val769Leu EGFR ENST00000275493.6 3633 3236 1777230 1777230 1681233 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983497 983497 899215 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264384 2264384 2131368 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1774664 1774664 1678888 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22993320 surgery - NOS metastasis 55 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 IRG 897733 815355 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15118125 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2105809 2105809 1983847 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096156 2096156 1974220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083811 1083811 998976 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637703 2637703 2498076 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 897812 897812 815434 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2027752 2027752 1909655 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1921908 1921908 1809226 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881389 1881389 1771540 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 1243168 1243168 1154880 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 19692773 NS recurrent 73 ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231325 1231325 1143115 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895067 1895067 1783759 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675681 2675681 2534955 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110457 1110457 1024335 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067044 1067044 983024 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BC3-1 2824190 2680014 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51801471 COSM53105 132553118 c.2357G>A p.R786H Substitution - Missense 38 7:55191741-55191741 + - PATHOGENIC .96289 Reported in another cancer sample as somatic 31867841 circulating tumour recurrent 43 ENSP00000395243.3:p.Arg786His ENST00000454757.6:c.2357G>A 7:g.55191741G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1235142 1235142 1146928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 57 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625562 2625562 2485974 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 132553412 c.2477C>G p.A826G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 27056568 surgery-fixed NS 51 ENSP00000395243.3:p.Ala826Gly ENST00000454757.6:c.2477C>G 7:g.55191861C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110462 1110462 1024340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1625790 1625790 1543014 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1966329 1966329 1852822 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2131916 2131916 2005979 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24376723 surgery-fixed metastasis ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879537 1879537 1770039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983736 1983736 1869972 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 11-18 1731372 1637338 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22815900 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1333426 1333426 1243900 salivary_gland parotid NS NS carcinoma salivary_duct_carcinoma NS NS n COSV51807024 COSM41905 132561313 c.1957G>A p.A653T Substitution - Missense 38 7:55173951-55173951 + - PATHOGENIC .96084 Variant of unknown origin 20371674 surgery-fixed NS 73 ENSP00000395243.3:p.Ala653Thr ENST00000454757.6:c.1957G>A 7:g.55173951G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-55-6968-01 1913999 1802281 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51765668 COSM13198 132553967 c.2461G>A p.E821K Substitution - Missense 38 7:55191845-55191845 + - PATHOGENIC .98912 Variant of unknown origin 417 fresh/frozen - NOS primary 61 ENSP00000395243.3:p.Glu821Lys ENST00000454757.6:c.2461G>A 7:g.55191845G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S29 1063226 979271 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770520 1770520 1674760 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2344944 2344944 2209616 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25674250 NS NS 80 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029011 2029011 1910893 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230482 1230482 1142296 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 1230482 1230482 1142296 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990911 1990911 1876246 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166418 1166418 1078732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51786190 COSM28606 132551453 c.2429A>G p.D810G Substitution - Missense het 38 7:55191813-55191813 + - PATHOGENIC .9858 Variant of unknown origin 16870303 surgery - NOS NS 59 ENSP00000395243.3:p.Asp810Gly ENST00000454757.6:c.2429A>G 7:g.55191813A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226899 2226899 2094634 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453431 1453431 1377464 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152689 2152689 2021699 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24768118 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1816948 1816948 1716116 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1223076 1223076 1134908 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 19473722 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1202563 1202563 1114449 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1074999 1074999 990253 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 55 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659805 2659805 2519963 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042903 1042903 959244 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429279 1429279 1338730 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2898918 2898918 2753189 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS n COSV105863717 COSM9973511 132548818 c.2302T>G p.Y768D Substitution - Missense het 38 7:55181446-55181446 + - PATHOGENIC .71023 Variant of unknown origin 27460089 blood-bone marrow NS ENSP00000395243.3:p.Tyr768Asp ENST00000454757.6:c.2302T>G 7:g.55181446T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732608 2732608 2591361 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779091 COSM2155593 132560457 c.953C>T p.T318I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Reported in another cancer sample as somatic 26757882 surgery-fixed primary 57 ENSP00000395243.3:p.Thr318Ile ENST00000454757.6:c.953C>T 7:g.55156614C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CCK-81_R1_Cetux 2841357 2696917 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 132562107 c.1256C>T p.S419L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000395243.3:p.Ser419Leu ENST00000454757.6:c.1256C>T 7:g.55160231C>T EGFR ENST00000275493.6 3633 3236 1816949 1816949 1716117 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1493331 1493331 1416321 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141312 1141312 1053760 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591047 1591047 1512163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591047 1591047 1512163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM28739 178379146 c.? p.D761Y Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Asp761Tyr EGFR ENST00000275493.6 3633 3236 2214575 2214575 2082699 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1122178 1122178 1035222 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18418018 surgery - NOS NS 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2867740 2867740 2722763 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25345567 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875383 1875383 1765966 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 V180 1179747 1091709 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KT-4 1047094 963325 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17332333 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231314 1231314 1143104 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1434023 1434023 1343438 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899350 899350 816962 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875794 1875794 1766377 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891279 1891279 1780648 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924338 924338 841113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983740 1983740 1869976 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899306 899306 816918 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 946825 946825 863348 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1981022 1981022 1867258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983832 1983832 1870068 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077343 1077343 992597 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-16-A36234 2905681 2759937 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LU-65 946067 862593 lung NS NS NS carcinoma giant_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625560 2625560 2485972 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 132553412 c.2477C>G p.A826G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 27056568 surgery-fixed NS 51 ENSP00000395243.3:p.Ala826Gly ENST00000454757.6:c.2477C>G 7:g.55191861C>G EGFR ENST00000275493.6 3633 3236 5325 915997 833396 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51789625 COSM13197 99376708 c.2590G>A p.A864T Substitution - Missense 38 7:55191839-55191839 + - PATHOGENIC .9615 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000275493.2:p.Ala864Thr ENST00000275493.6:c.2590G>A 7:g.55191839G>A EGFR ENST00000275493.6 3633 3236 1284677 1284677 1195972 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 16467085 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103639 1103639 1017891 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51795632 COSM26509 133221986 c.2092G>A p.A698T Substitution - Missense 38 7:55174764-55174764 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 81 ENSP00000415559.1:p.Ala698Thr ENST00000455089.5:c.2092G>A 7:g.55174764G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659802 2659802 2519960 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CT31 1063205 979250 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 52 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CT31 1063205 979250 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 52 ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 924993 924993 841766 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16133419 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1135549 1135549 1048113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 18676761 NS NS 45 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1135549 1135549 1048113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18676761 NS NS 45 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459767 1459767 1383710 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 21062932 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2552058 2552058 2413499 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51788909 COSM5967252 132556258 c.2453G>T p.G818V Substitution - Missense 38 7:55191837-55191837 + - PATHOGENIC .95501 Variant of unknown origin 26517354 surgery-fixed NS ENSP00000395243.3:p.Gly818Val ENST00000454757.6:c.2453G>T 7:g.55191837G>T EGFR ENST00000275493.6 3633 3236 1089606 1089606 1004553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1789315 1789315 1692719 lung NS NS NS carcinoma NS NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2402748 2402748 2265601 breast NS NS NS carcinoma luminal_A_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 26267891 surgery-fixed primary 87 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1637232 1637232 1553280 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00357T00357 2857360 2712660 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895064 1895064 1783756 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1576783 1576783 1498224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 63 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 12 2570180 2431477 skin neck NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51798694 COSM18419 133277561 c.2065G>A p.E689K Substitution - Missense 38 7:55174737-55174737 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 60 ENSP00000415559.1:p.Glu689Lys ENST00000455089.5:c.2065G>A 7:g.55174737G>A EGFR ENST00000275493.6 3633 3236 2228271 2228271 2096003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5325 915997 833396 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51789625 COSM13197 133204854 c.2455G>A p.A819T Substitution - Missense 38 7:55191839-55191839 + - PATHOGENIC .9615 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000415559.1:p.Ala819Thr ENST00000455089.5:c.2455G>A 7:g.55191839G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1141193 1141193 1053641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 18785203 autopsy-fixed NS 76 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166431 1166431 1078745 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51803731 COSM28604 132550372 c.2371C>T p.R791C Substitution - Missense het 38 7:55191755-55191755 + - PATHOGENIC .95213 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 48 ENSP00000395243.3:p.Arg791Cys ENST00000454757.6:c.2371C>T 7:g.55191755C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2616329 2616329 2476815 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26118982 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875336 1875336 1765919 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1746661 1746661 1651637 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 73 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1596614 1596614 1517396 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22071596 surgery - NOS NS 64 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618793 1618793 1537545 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 65 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1445184 1445184 1369427 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 20682976 surgery - NOS metastasis 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2153076 2153076 2022086 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2426848 2426848 2289769 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422835 2422835 2285757 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1435996 1435996 1345275 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 20439191 surgery fresh/frozen NS 59 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1471895 1471895 1395633 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 20871262 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2552454 2552454 2413895 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27553514 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1994271 1994271 1879526 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23886169 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 3617 915988 833387 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51790305 COSM13194 133206846 c.2405C>T p.T802I Substitution - Missense 38 7:55191789-55191789 + - PATHOGENIC .95119 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000415559.1:p.Thr802Ile ENST00000455089.5:c.2405C>T 7:g.55191789C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1881389 1881389 1771540 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 133203995 c.2183A>T p.H728L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000415559.1:p.His728Leu ENST00000455089.5:c.2183A>T 7:g.55181327A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1789324 1789324 1692728 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732924 2732924 2591677 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 64 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879563 1879563 1770065 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 4624 915977 833376 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766268 COSM13183 132550670 c.2090T>C p.V697A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000395243.3:p.Val697Ala ENST00000454757.6:c.2090T>C 7:g.55174762T>C EGFR ENST00000275493.6 3633 3236 2867740 2867740 2722763 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25345567 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 BL-17-M17595 2905164 2759420 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51845233 COSM3734669 99380080 c.2218A>G p.I740V Substitution - Missense 38 7:55174755-55174755 + - PATHOGENIC .99591 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Ile740Val ENST00000275493.6:c.2218A>G 7:g.55174755A>G EGFR ENST00000275493.6 3633 3236 1469873 1469873 1393612 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1802254 1802254 1703973 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23136191 surgery-fixed NS 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1113048 1113048 1026549 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 18458038 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1596621 1596621 1517403 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 22071596 blood-bone marrow NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2106565 2106565 1984428 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2079980 2079980 1958542 lung NS NS NS carcinoma signet_ring_cell_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24419120 surgery - NOS primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2073885 2073885 1953051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24370197 NS NS 46 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1047 2491942 2354571 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour borderline NS n COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 26437033 surgery fresh/frozen NS 63 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00196T00196 2857366 2712666 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2346539 2346539 2211202 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656981 1656981 1571636 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22338650 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230451 1230451 1142265 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174305 1174305 1086324 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983123 983123 898841 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345430 2345430 2210102 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425766 2425766 2288687 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264185 2264185 2131169 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345485 2345485 2210157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618793 1618793 1537545 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444579 1444579 1368824 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20686428 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237700 1237700 1149447 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637241 1637241 1553289 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705461 1705461 1613367 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421221 2421221 2284143 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474456 2474456 2337225 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218532 2218532 2086543 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914942 1914942 1802944 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214523 2214523 2082647 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1489671 1489671 1412829 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21155184 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264162 2264162 2131146 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983133 983133 898851 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008971 2008971 1891705 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23979198 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638778 1638778 1554777 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1062891 1062891 978936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17387741 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2273787 2273787 2140347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25300933 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421226 2421226 2284148 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173392 1173392 1085476 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246701 1246701 1158380 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2426848 2426848 2289769 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637118 1637118 1553166 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422835 2422835 2285757 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1489878 1489878 1413036 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21224376 surgery-fixed recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345390 2345390 2210062 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665719 2665719 2525428 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS primary 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345509 2345509 2210181 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2350423 2350423 2214794 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23357969 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921923 1921923 1809241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885183 1885183 1775070 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637702 2637702 2498075 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 circulating tumour recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838660 1838660 1732761 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1046993 1046993 963224 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1202556 1202556 1114442 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891179 1891179 1780548 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1991297 1991297 1876632 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602804 1602804 1522140 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453421 1453421 1377454 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920167 920167 837247 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-64-1681-01 1914034 1802316 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 61 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891291 1891291 1780660 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1694971 1694971 1603191 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602811 1602811 1522147 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1637085 1637085 1553133 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1981001 1981001 1867241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23842453 surgery fresh/frozen primary 31 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2078466 2078466 1957185 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1695744 1695744 1603956 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22673630 fine needle aspirate primary 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838683 1838683 1732784 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1435656 1435656 1344935 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20661086 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096115 2096115 1974179 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264220 2264220 2131204 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770560 1770560 1674800 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2141453 2141453 2010671 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24636848 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264275 2264275 2131259 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1610408 1610408 1529648 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22142557 pleural effusion NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264270 2264270 2131254 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965855 1965855 1852348 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469497 1469497 1393236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264259 2264259 2131243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1471803 1471803 1395541 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51827262 COSM53226 99389764 c.2099A>G p.N700S Substitution - Missense 38 7:55173958-55173958 + - PATHOGENIC .97158 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000275493.2:p.Asn700Ser ENST00000275493.6:c.2099A>G 7:g.55173958A>G EGFR ENST00000275493.6 3633 3236 2007937 2007937 1890672 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23907151 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226887 2226887 2094622 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1202552 1202552 1114438 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1751712 1751712 1656528 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895091 1895091 1783783 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231319 1231319 1143109 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042907 1042907 959248 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1054403 1054403 970474 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067043 1067043 983023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914807 914807 832256 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450925 1450925 1375068 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 61 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631956 1631956 1548826 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875365 1875365 1765948 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239176 2239176 2106708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 47 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 911619 911619 829102 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110468 1110468 1024346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043858 1043858 960199 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862709 2862709 2717872 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 6359 915960 833359 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51807685 COSM13177 132563758 c.1928T>C p.L643P Substitution - Missense 38 7:55173922-55173922 + - PATHOGENIC .97819 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000395243.3:p.Leu643Pro ENST00000454757.6:c.1928T>C 7:g.55173922T>C EGFR ENST00000275493.6 3633 3236 1469431 1469431 1393170 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218542 2218542 2086553 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264172 2264172 2131156 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676416 1676416 1589184 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450936 1450936 1375079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 77 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00346T00346 2857341 2712641 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00192T00192 2857326 2712626 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899310 899310 816922 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777407 1777407 1681410 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1029025 1029025 945896 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 17075123 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1653413 1653413 1568200 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22333630 NS NS 76 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1336429 1336429 1246814 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 20430469 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1770650 1770650 1674890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345436 2345436 2210108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1658061 1658061 1572505 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22458769 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475409 1475409 1399108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777336 1777336 1681339 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106551 2106551 1984414 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1624108 1624108 1541695 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21681971 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842959 1842959 1736207 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921918 1921918 1809236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625580 2625580 2485992 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 74 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1668666 1668666 1581958 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22523351 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535047 1535047 1457382 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1107778 1107778 1021681 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1512563 1512563 1435247 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21362302 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345800 2345800 2210472 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264272 2264272 2131256 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264333 2264333 2131317 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965860 1965860 1852353 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218975 2218975 2086959 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25056302 NS NS 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2406821 2406821 2269701 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1223899 1223899 1135731 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19517135 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142085 2142085 2011303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 49 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1530987 1530987 1453359 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027866 2027866 1909769 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2491464 2491464 2354110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26885207 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881897 1881897 1772048 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618694 1618694 1537446 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1514599 1514599 1437209 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21558399 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471808 1471808 1395546 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51853427 COSM53230 132603786 c.2462A>G p.E821G Substitution - Missense 38 7:55191846-55191846 + - PATHOGENIC .986 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000395243.3:p.Glu821Gly ENST00000454757.6:c.2462A>G 7:g.55191846A>G EGFR ENST00000275493.6 3633 3236 2595743 2595743 2456619 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1166943 178385114 c.? p.V769L Substitution - Missense + - Reported in another cancer sample as somatic 27538584 fine needle aspirate NS 68 ENSP00000275493.2:p.Val769Leu EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1456558 1456558 1380533 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1884154 1884154 1774041 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 HRA19 2301986 2167269 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51788818 COSM4638027 132556087 c.2825T>G p.M942R Substitution - Missense het 38 7:55201201-55201201 + - PATHOGENIC .99397 Variant of unknown origin 24755471 cell-line NS ENSP00000395243.3:p.Met942Arg ENST00000454757.6:c.2825T>G 7:g.55201201T>G EGFR ENST00000275493.6 3633 3236 2011142 2011142 1893780 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM30754 178378833 c.? p.L747P Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu747Pro EGFR ENST00000275493.6 3633 3236 2345068 2345068 2209740 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1777366 1777366 1681369 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1661845 1661845 1575458 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22487432 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264247 2264247 2131231 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1481250 1481250 1404879 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592982 1592982 1513908 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51824363 COSM133206 132560993 c.2395C>G p.L799V Substitution - Missense 38 7:55191779-55191779 + - PATHOGENIC .9686 Variant of unknown origin 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu799Val ENST00000454757.6:c.2395C>G 7:g.55191779C>G EGFR ENST00000275493.6 3633 3236 2757343 2757343 2615980 lung right NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28274743 surgery - NOS metastasis 41 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106553 2106553 1984416 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1036629 1036629 953386 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 17201173 NS NS ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 1921734 1921734 1809052 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense hom + - Reported in another cancer sample as somatic 23620765 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1000054 1000054 917277 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1914939 1914939 1802941 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1097635 1097635 1012296 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1097635 1097635 1012296 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278389 1278389 1189687 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19376842 surgery - NOS primary 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862733 2862733 2717896 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 2862733 2862733 2717896 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51796944 COSM28537 99382129 c.2560A>G p.T854A Substitution - Missense 38 7:55191809-55191809 + - PATHOGENIC .9858 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Thr854Ala ENST00000275493.6:c.2560A>G 7:g.55191809A>G EGFR ENST00000275493.6 3633 3236 2345064 2345064 2209736 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1875337 1875337 1765920 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043863 1043863 960204 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302294 1302294 1213345 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166441 1166441 1078755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 37 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136863 1136863 1049427 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 98 897199 814822 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15329413 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594125 1594125 1515050 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724887 surgery fresh/frozen NS 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166440 1166440 1078754 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043862 1043862 960203 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891185 1891185 1780554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914812 914812 832261 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001303-T03-IM5 2719408 2578229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005357 1005357 922569 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162203 1162203 1074535 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897819 897819 815441 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2007941 2007941 1890676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 133206440 c.2113G>C p.A705P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Reported in another cancer sample as somatic 23907151 fine needle aspirate metastasis ENSP00000415559.1:p.Ala705Pro ENST00000455089.5:c.2113G>C 7:g.55174785G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879566 1879566 1770068 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239185 2239185 2106717 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 25130612 fine needle aspirate NS 68 ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239185 2239185 2106717 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 fine needle aspirate NS 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 109598 2812902 2669316 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 44 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-162-tumor 2819060 2675359 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 MG-024-tumor 2818985 2675284 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1083067 1083067 998232 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17685931 surgery-fixed NS 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345805 2345805 2210477 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2402523 2402523 2265379 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547774 1547774 1469896 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 58 ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 1547774 1547774 1469896 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 58 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1547774 1547774 1469896 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 58 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2000226 2000226 1885124 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891224 1891224 1780593 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891183 1891183 1780552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471808 1471808 1395546 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51770642 COSM22992 132553893 c.2026G>A p.G676S Substitution - Missense 38 7:55174020-55174020 + - PATHOGENIC .98289 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000395243.3:p.Gly676Ser ENST00000454757.6:c.2026G>A 7:g.55174020G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895108 1895108 1783800 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009154 2009154 1891888 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166426 1166426 1078740 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51824140 COSM28602 132574618 c.2097C>G p.I699M Substitution - Missense hom 38 7:55174769-55174769 + - PATHOGENIC .97142 Variant of unknown origin 16870303 surgery - NOS NS 55 ENSP00000395243.3:p.Ile699Met ENST00000454757.6:c.2097C>G 7:g.55174769C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 19 2570191 2431488 skin face NS NS adnexal_tumour other sebaceoma NS n COSV51828226 COSM5991529 132573752 c.2143C>T p.L715F Substitution - Missense 38 7:55174815-55174815 + - PATHOGENIC .89342 Variant of unknown origin 27311873 surgery-fixed NS 71 ENSP00000395243.3:p.Leu715Phe ENST00000454757.6:c.2143C>T 7:g.55174815C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043873 1043873 960214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51770642 COSM22992 132553893 c.2026G>A p.G676S Substitution - Missense 38 7:55174020-55174020 + - PATHOGENIC .98289 Variant of unknown origin 17192902 NS NS ENSP00000395243.3:p.Gly676Ser ENST00000454757.6:c.2026G>A 7:g.55174020G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1235136 1235136 1146922 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 65 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1964342 1964342 1850877 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1166943 178385114 c.? p.V769L Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Val769Leu EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471811 1471811 1395549 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51795335 COSM53232 132581114 c.1987A>G p.K663E Substitution - Missense 38 7:55173981-55173981 + - PATHOGENIC .98155 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000395243.3:p.Lys663Glu ENST00000454757.6:c.1987A>G 7:g.55173981A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1202558 1202558 1114444 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2422826 2422826 2285748 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1838694 1838694 1732795 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862240 2862240 2717430 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25969368 surgery-fixed primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1549811 1549811 1471916 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 71 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1945218 1945218 1832128 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51767379 COSM85894 99384993 c.2527G>A p.V843I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 23295441 surgery-fixed NS ENSP00000275493.2:p.Val843Ile ENST00000275493.6:c.2527G>A 7:g.55191776G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TC71 2294589 2160616 bone NS NS NS Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour NS NS NS y COSV51765987 COSM4587485 132614217 c.3007G>T p.A1003S Substitution - Missense 38 7:55201762-55201762 + - NEUTRAL .47883 Variant of unknown origin 25186949 cell-line NS ENSP00000395243.3:p.Ala1003Ser ENST00000454757.6:c.3007G>T 7:g.55201762G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EGCT0002 2490752 2353401 testis NS NS NS germ_cell_tumour seminoma NS NS n COSV51794554 COSM5749111 132557739 c.2555T>C p.V852A Substitution - Missense 38 7:55192830-55192830 + - PATHOGENIC .94427 Variant of unknown origin 26956871 surgery fresh/frozen primary ENSP00000395243.3:p.Val852Ala ENST00000454757.6:c.2555T>C 7:g.55192830T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PEN-157 2843148 2698601 skin NS NS NS benign_melanocytic_nevus NS NS NS n COSV104576988 COSM9515585 132565977 c.2581G>A p.E861K Substitution - Missense 38 7:55198731-55198731 + - PATHOGENIC .99414 Variant of unknown origin 27890785 surgery-fixed NS ENSP00000395243.3:p.Glu861Lys ENST00000454757.6:c.2581G>A 7:g.55198731G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2637592 2637592 2497965 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51826065 COSM6438146 132578895 c.1956A>T p.E652D Substitution - Missense 38 7:55173950-55173950 + - PATHOGENIC .86906 Variant of unknown origin 27105513 surgery-fixed NS ENSP00000395243.3:p.Glu652Asp ENST00000454757.6:c.1956A>T 7:g.55173950A>T EGFR ENST00000275493.6 3633 3236 2029007 2029007 1910889 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148621 2148621 2017751 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425730 2425730 2288651 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2676364 2676364 2535638 penis NS NS NS in_situ_neoplasm penile_intraepithelial_neoplasia_Grade_3 NS NS n COSM34166 178380439 c.? p.R108K Substitution - Missense + - Reported in another cancer sample as somatic 26216163 surgery-fixed NS ENSP00000275493.2:p.Arg108Lys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2791158 2791158 2648356 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense hom 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 30922580 pleural effusion metastasis 60 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1333428 1333428 1243902 salivary_gland parotid NS NS carcinoma salivary_duct_carcinoma NS NS n COSV51785879 COSM29274 132577669 c.2119T>C p.S707P Substitution - Missense 38 7:55174791-55174791 + - PATHOGENIC .99066 Variant of unknown origin 20371674 surgery-fixed NS 58 ENSP00000395243.3:p.Ser707Pro ENST00000454757.6:c.2119T>C 7:g.55174791T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 AC-V10-Tumor-SM-9J465 2584480 2445644 large_intestine anus NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51802062 COSM6008937 132557741 c.524C>T p.S175F Substitution - Missense 38 7:55152576-55152576 + - PATHOGENIC .98424 Variant of unknown origin 27852700 surgery-fixed primary ENSP00000395243.3:p.Ser175Phe ENST00000454757.6:c.524C>T 7:g.55152576C>T EGFR ENST00000275493.6 3633 3236 IRG 897733 815355 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15118125 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777227 1777227 1681230 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264314 2264314 2131298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1242316 1242316 1154046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777111 COSM33725 133215620 c.2474A>G p.H825R Substitution - Missense het 38 7:55191858-55191858 + - PATHOGENIC .97748 Reported in another cancer sample as somatic 19671738 surgery-fixed primary 56 ENSP00000415559.1:p.His825Arg ENST00000455089.5:c.2474A>G 7:g.55191858A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166430 1166430 1078744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773222 COSM28608 132578158 c.2258T>A p.L753H Substitution - Missense het 38 7:55181402-55181402 + - PATHOGENIC .95568 Variant of unknown origin 16870303 surgery - NOS NS 51 ENSP00000395243.3:p.Leu753His ENST00000454757.6:c.2258T>A 7:g.55181402T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453422 1453422 1377455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593024 1593024 1513950 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1493352 1493352 1416342 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1517893 1517893 1440271 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21572125 fine needle aspirate NS 87 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1567516 1567516 1489148 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM22423 178380012 c.? p.P733S Substitution - Missense + - Reported in another cancer sample as somatic 21949883 fine needle aspirate metastasis ENSP00000275493.2:p.Pro733Ser EGFR ENST00000275493.6 3633 3236 1231325 1231325 1143115 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2865564 2865564 2720694 lung NS NS NS carcinoma adenocarcinoma transformed_to_small_cell_carcinoma NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29120087 surgery-fixed recurrent 47 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965838 1965838 1852331 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860419 1860419 1751360 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1705529 1705529 1613435 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1891314 1891314 1780683 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231311 1231311 1143101 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MBC528 2807307 2664011 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99296827 COSM9120819 132617080 c.2159T>A p.V720E Substitution - Missense 38 7:55181303-55181303 + - PATHOGENIC .97894 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000395243.3:p.Val720Glu ENST00000454757.6:c.2159T>A 7:g.55181303T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897822 897822 815444 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2664367 2664367 2524426 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2665670 2665670 2525379 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28978102 surgery - NOS metastasis 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1284675 1284675 1195970 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 16467085 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2144804 2144804 2014018 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24675505 surgery - NOS metastasis 44 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1237704 1237704 1149451 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2908159 2908159 2762333 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 33260286 surgery - NOS NS 64 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481236 1481236 1404865 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2148642 2148642 2017772 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166428 1166428 1078742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773206 COSM28603 133217070 c.2158G>A p.V720M Substitution - Missense het 38 7:55181302-55181302 + - PATHOGENIC .97963 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 67 ENSP00000415559.1:p.Val720Met ENST00000455089.5:c.2158G>A 7:g.55181302G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043861 1043861 960202 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2432372 2432372 2295275 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 26473643 surgery fresh/frozen metastasis 56 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891288 1891288 1780657 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1695224 1695224 1603444 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51799102 COSM28513 132559266 c.2215T>C p.S739P Substitution - Missense 38 7:55181359-55181359 + - PATHOGENIC .95834 Variant of unknown origin 22607702 surgery-fixed NS ENSP00000395243.3:p.Ser739Pro ENST00000454757.6:c.2215T>C 7:g.55181359T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1661390 1661390 1575005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830604 COSM214351 132559260 c.2204T>C p.I735T Substitution - Missense 38 7:55181348-55181348 + - PATHOGENIC .97073 Variant of unknown origin 22483783 surgery-fixed NS 57 ENSP00000395243.3:p.Ile735Thr ENST00000454757.6:c.2204T>C 7:g.55181348T>C EGFR ENST00000275493.6 3633 3236 MG-273-tumor 2819121 2675420 meninges NS NS NS meningioma anaplastic NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00320T00320 2857338 2712638 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2675681 2675681 2534955 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1838722 1838722 1732823 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879537 1879537 1770039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1983736 1983736 1869972 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2549139 2549139 2410594 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838638 1838638 1732739 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2156968 2156968 2025943 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2028994 2028994 1910876 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891314 1891314 1780683 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1661375 1661375 1574990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 22483783 surgery-fixed NS 82 ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 1770705 1770705 1674945 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1664608 1664608 1578058 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21899495 pleural effusion NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027862 2027862 1909765 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027862 2027862 1909765 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 11-18 1731372 1637338 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22815900 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1812625 1812625 1711959 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23174717 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774674 1774674 1678898 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 pleural effusion recurrent 84 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637224 1637224 1553272 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2218429 2218429 2086440 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25076890 surgery - NOS metastasis 79 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1990911 1990911 1876246 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1812626 1812626 1711960 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23174717 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179655 1179655 1091617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525692 2525692 2387881 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656983 1656983 1571638 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22338650 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2161695 2161695 2030302 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24813888 surgery fresh/frozen recurrent 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2161695 2161695 2030302 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 24813888 surgery fresh/frozen recurrent 58 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732935 2732935 2591688 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 72 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450880 1450880 1375023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924340 924340 841115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2595743 2595743 2456619 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 fine needle aspirate NS 68 ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891192 1891192 1780561 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862100 2862100 2717302 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51830861 COSM6219 133206440 c.2113G>C p.A705P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000415559.1:p.Ala705Pro ENST00000455089.5:c.2113G>C 7:g.55174785G>C EGFR ENST00000275493.6 3633 3236 2659636 2659636 2519794 pleura NS NS NS mesothelioma epithelial NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 28838714 pleural effusion NS 55 ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 2659636 2659636 2519794 pleura NS NS NS mesothelioma epithelial NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 28838714 pleural effusion NS 55 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1816948 1816948 1716116 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1531002 1531002 1453374 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734093 1734093 1640042 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22842370 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246484 1246484 1158163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469418 1469418 1393157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345487 2345487 2210159 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618013 1618013 1536809 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22185996 surgery - NOS metastasis 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345548 2345548 2210220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1530990 1530990 1453362 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2157003 2157003 2025978 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046022 2046022 1926317 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2078468 2078468 1957187 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095994 2095994 1974058 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777256 1777256 1681259 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881896 1881896 1772047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096030 2096030 1974094 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264346 2264346 2131330 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638728 1638728 1554727 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1661844 1661844 1575457 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22487432 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046610 2046610 1926904 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1122179 1122179 1035223 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18418018 surgery - NOS NS 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214539 2214539 2082663 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665720 2665720 2525429 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS recurrent 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045962 2045962 1926257 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844333 1844333 1737367 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083089 2083089 1961510 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24300726 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173390 1173390 1085474 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000178 2000178 1885076 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838685 1838685 1732786 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1284675 1284675 1195970 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16467085 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444761 1444761 1369004 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1733682 1733682 1639631 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22836289 surgery-fixed NS 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264133 2264133 2131117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096119 2096119 1974183 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014315 1014315 931489 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542343 1542343 1464646 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1733678 1733678 1639627 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22836289 surgery-fixed NS 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 999904 999904 917127 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16827805 pleural effusion NS 48 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237704 1237704 1149451 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535049 1535049 1457384 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425756 2425756 2288677 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246631 1246631 1158310 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618051 1618051 1536847 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637093 1637093 1553141 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046025 2046025 1926320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083813 1083813 998978 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964326 1964326 1850861 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345479 2345479 2210151 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983132 983132 898850 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965276 1965276 1851771 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23803047 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1599061 1599061 1519548 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22091430 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345494 2345494 2210166 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842965 1842965 1736213 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095983 2095983 1974047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083069 1083069 998234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17685931 surgery-fixed NS 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469349 1469349 1393088 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166430 1166430 1078744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773249 COSM28610 132578167 c.2306T>C p.L769P Substitution - Missense het 38 7:55181450-55181450 + - PATHOGENIC .94523 Variant of unknown origin 16870303 surgery - NOS NS 51 ENSP00000395243.3:p.Leu769Pro ENST00000454757.6:c.2306T>C 7:g.55181450T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 RERF-LC-OK 946065 862591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983747 1983747 1869983 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891277 1891277 1780646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875360 1875360 1765943 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895090 1895090 1783782 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1451762 1451762 1375811 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20615575 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1489665 1489665 1412823 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21155184 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777238 1777238 1681241 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345415 2345415 2210087 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2819295 2819295 2675594 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 30711944 pleural effusion recurrent 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734092 1734092 1640041 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22842370 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965844 1965844 1852337 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008967 2008967 1891701 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23979198 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983146 983146 898864 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1075011 1075011 990265 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1140665 1140665 1053113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26131 178380442 c.? p.E746V Substitution - Missense + - Reported in another cancer sample as somatic 19238633 surgery-fixed primary 42 ENSP00000275493.2:p.Glu746Val EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2840787 2840787 2696347 prostate NS NS NS carcinoma NS NS NS n COSV51807481 COSM1716255 132553158 c.2017C>A p.L673M Substitution - Missense 38 7:55174011-55174011 + - PATHOGENIC .91907 Variant of unknown origin 31874108 surgery-fixed primary ENSP00000395243.3:p.Leu673Met ENST00000454757.6:c.2017C>A 7:g.55174011C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231312 1231312 1143102 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1054391 1054391 970462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067073 1067073 983053 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2148647 2148647 2017777 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000454757 ENST00000454757.6 3498 3236 B00527 2767140 2625359 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV99034451 COSM7346340 132547684 c.3461G>T p.R1154M Substitution - Missense 38 7:55205580-55205580 + - PATHOGENIC .94501 Variant of unknown origin 30200630 surgery-fixed NS ENSP00000395243.3:p.Arg1154Met ENST00000454757.6:c.3461G>T 7:g.55205580G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043870 1043870 960211 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51787381 COSM22991 132578775 c.2195T>A p.L732Q Substitution - Missense 38 7:55181339-55181339 + - PATHOGENIC .97894 Variant of unknown origin 17192902 NS NS ENSP00000395243.3:p.Leu732Gln ENST00000454757.6:c.2195T>A 7:g.55181339T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675371 2675371 2534645 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51776282 COSM1168015 132547141 c.2123C>T p.P708L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Reported in another cancer sample as somatic 29100434 surgery - NOS recurrent ENSP00000395243.3:p.Pro708Leu ENST00000454757.6:c.2123C>T 7:g.55174795C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2579438 2579438 2440775 NS NS NS NS malignant_melanoma NS NS NS n COSV51781415 COSM6005739 132583412 c.326G>A p.G109E Substitution - Missense 38 7:55143390-55143390 + - PATHOGENIC .99562 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000395243.3:p.Gly109Glu ENST00000454757.6:c.326G>A 7:g.55143390G>A EGFR ENST00000275493.6 3633 3236 1587285 1587285 1508456 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1481224 1481224 1404853 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2659802 2659802 2519960 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1637219 1637219 1553267 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444576 1444576 1368821 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20686428 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2115440 2115440 1989684 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23915069 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2032223 2032223 1913694 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 CT31 1063205 979250 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 52 ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 CT31 1063205 979250 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 52 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1196942 1196942 1108837 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096170 2096170 1974234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891180 1891180 1780549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-275-tumor 2819122 2675421 meninges NS NS NS meningioma anaplastic NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891304 1891304 1780673 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860427 1860427 1751368 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2105805 2105805 1983843 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1093897 1093897 1008599 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18061305 pleural effusion NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1789315 1789315 1692719 lung NS NS NS carcinoma NS NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 2345088 2345088 2209760 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1887383 1887383 1777055 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402748 2402748 2265601 breast NS NS NS carcinoma luminal_A_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 26267891 surgery-fixed primary 87 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1777361 1777361 1681364 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551556 1551556 1473661 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240678 2240678 2108209 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 57 ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732934 2732934 2591687 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51771844 COSM7002278 132558352 c.2806A>C p.I936L Substitution - Missense 38 7:55200408-55200408 + - PATHOGENIC .99358 Variant of unknown origin 28855349 surgery - NOS primary 72 ENSP00000395243.3:p.Ile936Leu ENST00000454757.6:c.2806A>C 7:g.55200408A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042911 1042911 959252 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897823 897823 815445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EBC-1 946069 862595 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EBC-1 946069 862595 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1468069 1468069 1391915 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 48 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746662 1746662 1651638 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 66 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2148632 2148632 2017762 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1610405 1610405 1529645 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22142557 pleural effusion NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481229 1481229 1404858 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481255 1481255 1404884 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1964344 1964344 1850879 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1585367 1585367 1506688 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22011666 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525722 2525722 2387910 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1246490 1246490 1158169 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1585365 1585365 1506686 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22011666 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096234 2096234 1974298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081906 2081906 1960328 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2429759 2429759 2292663 lung right NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26400668 surgery - NOS metastasis 76 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525675 2525675 2387864 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081907 2081907 1960329 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032190 2032190 1913661 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 cerebrospinal fluid recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2079980 2079980 1958542 lung NS NS NS carcinoma signet_ring_cell_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24419120 surgery - NOS primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 NPC0001PT00357T00357 2857360 2712660 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1992085 1992085 1877402 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 50 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2651874 2651874 2512014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 132557758 c.2018T>A p.L673Q Substitution - Missense hom 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Reported in another cancer sample as somatic 27257132 surgery - NOS recurrent 71 ENSP00000395243.3:p.Leu673Gln ENST00000454757.6:c.2018T>A 7:g.55174012T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2651874 2651874 2512014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27257132 surgery - NOS recurrent 71 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2651874 2651874 2512014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 27257132 surgery - NOS recurrent 71 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732913 2732913 2591666 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 132550339 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 60 ENSP00000395243.3:p.Ala244Asp ENST00000454757.6:c.731C>A 7:g.55154129C>A EGFR ENST00000275493.6 3633 3236 DH402C 2762552 2620811 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51780730 COSM22940 99378223 c.2327G>A p.R776H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 29615459 NS primary 65 ENSP00000275493.2:p.Arg776His ENST00000275493.6:c.2327G>A 7:g.55181336G>A EGFR ENST00000275493.6 3633 3236 2595760 2595760 2456636 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1667717 1667717 1581010 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1964294 1964294 1850829 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1964342 1964342 1850877 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043866 1043866 960207 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592991 1592991 1513917 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1894923 1894923 1783615 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2029004 2029004 1910886 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1768462 1768462 1672702 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22952784 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1623715 1623715 1541302 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21615826 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965872 1965872 1852365 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246743 1246743 1158422 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 MG-208-tumor 2819090 2675389 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 MG-023-tumor 2818984 2675283 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2595760 2595760 2456636 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996940 1996940 1882149 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148632 2148632 2017762 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777373 1777373 1681376 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083810 1083810 998975 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214534 2214534 2082658 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081928 2081928 1960350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24440279 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096008 2096008 1974072 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096145 2096145 1974209 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120928 1120928 1034084 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964344 1964344 1850879 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459513 1459513 1383456 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2560124 2560124 2421548 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26826182 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2067289 2067289 1947086 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23783797 NS NS 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345351 2345351 2210023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246694 1246694 1158373 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1168000 1168000 1080242 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19059670 surgery-fixed primary 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774685 1774685 1678909 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS primary 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430035 1430035 1339453 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547796 1547796 1469918 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 peritoneal washing recurrent 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875683 1875683 1766266 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141319 1141319 1053767 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591034 1591034 1512150 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937571 1937571 1824505 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1882242 1882242 1772393 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23392229 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148587 2148587 2017717 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346550 2346550 2211213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1465893 1465893 1389740 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838702 1838702 1732803 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914891 1914891 1802893 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083803 1083803 998968 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887368 1887368 1777040 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1062883 1062883 978928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17387741 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1099064 1099064 1013656 lung left_upper_lobe NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18192072 surgery-fixed NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966321 1966321 1852814 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226178 2226178 2093913 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081906 2081906 1960328 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081936 2081936 1960358 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24440279 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637176 1637176 1553224 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637094 1637094 1553142 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879426 1879426 1769931 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23464964 surgery-fixed NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096117 2096117 1974181 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148580 2148580 2017710 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665716 2665716 2525425 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS recurrent 58 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1202553 1202553 1114439 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2007943 2007943 1890678 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 133206440 c.2113G>C p.A705P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Reported in another cancer sample as somatic 23907151 fine needle aspirate metastasis ENSP00000415559.1:p.Ala705Pro ENST00000455089.5:c.2113G>C 7:g.55174785G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471806 1471806 1395544 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51799872 COSM53266 132588516 c.2030C>T p.A677V Substitution - Missense 38 7:55174024-55174024 + - PATHOGENIC .97625 Variant of unknown origin 21057220 surgery-fixed primary ENSP00000395243.3:p.Ala677Val ENST00000454757.6:c.2030C>T 7:g.55174024C>T EGFR ENST00000275493.6 3633 3236 P-0001303-T03-IM5 2719408 2578229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51807743 COSM133179 99396505 c.2065G>A p.V689M Substitution - Missense het 38 7:55173924-55173924 + - PATHOGENIC .9843 Reported in another cancer sample as somatic 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Val689Met ENST00000275493.6:c.2065G>A 7:g.55173924G>A EGFR ENST00000275493.6 3633 3236 1592872 1592872 1513798 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51807743 COSM133179 99396505 c.2065G>A p.V689M Substitution - Missense 38 7:55173924-55173924 + - PATHOGENIC .9843 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Val689Met ENST00000275493.6:c.2065G>A 7:g.55173924G>A EGFR ENST00000275493.6 3633 3236 BL-14-K41007 2905606 2759862 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2579268 2579268 2440605 NS NS NS NS malignant_melanoma NS NS NS n COSV51778029 COSM6268 133209348 c.2122C>T p.P708S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000415559.1:p.Pro708Ser ENST00000455089.5:c.2122C>T 7:g.55174794C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675161 2675161 2534435 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766300 COSM6849765 132550681 c.2102A>G p.E701G Substitution - Missense 38 7:55174774-55174774 + - PATHOGENIC .97324 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000395243.3:p.Glu701Gly ENST00000454757.6:c.2102A>G 7:g.55174774A>G EGFR ENST00000275493.6 3633 3236 3617 915988 833387 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51790305 COSM13194 99378747 c.2540C>T p.T847I Substitution - Missense 38 7:55191789-55191789 + - PATHOGENIC .95119 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000275493.2:p.Thr847Ile ENST00000275493.6:c.2540C>T 7:g.55191789C>T EGFR ENST00000275493.6 3633 3236 1542174 1542174 1464477 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1789324 1789324 1692728 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1047872 1047872 964101 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17228019 surgery - NOS NS 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2732924 2732924 2591677 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 64 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1879563 1879563 1770065 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2027860 2027860 1909763 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2214567 2214567 2082691 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1168002 1168002 1080244 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19059670 surgery-fixed primary 63 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-264-tumor 2819115 2675414 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1746657 1746657 1651633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 59 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746657 1746657 1651633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921935 1921935 1809253 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2110147 2110147 1986499 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24563335 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214540 2214540 2082664 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1881376 1881376 1771527 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891263 1891263 1780632 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983834 1983834 1870070 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-17-E51214 2905659 2759915 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864645 COSM9997785 132614795 c.1586G>A p.R529Q Substitution - Missense 38 7:55163822-55163822 + - PATHOGENIC .88204 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000395243.3:p.Arg529Gln ENST00000454757.6:c.1586G>A 7:g.55163822G>A EGFR ENST00000275493.6 3633 3236 2095981 2095981 1974045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1516779 1516779 1439373 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21575212 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451759 1451759 1375808 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20615575 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422914 2422914 2285836 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214541 2214541 2082665 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345467 2345467 2210139 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887386 1887386 1777058 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770659 1770659 1674899 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862851 2862851 2718013 lung left_upper_lobe NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31122564 surgery - NOS metastasis 41 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618705 1618705 1537457 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329256 1329256 1239741 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444793 1444793 1369036 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081907 2081907 1960329 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914954 1914954 1802956 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345492 2345492 2210164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1707033 1707033 1614939 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22695392 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469355 1469355 1393094 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1122167 1122167 1035211 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18379370 pleural effusion primary 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083071 1083071 998236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17685931 surgery-fixed NS 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774684 1774684 1678908 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 pleural effusion recurrent 87 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1196962 1196962 1108857 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469495 1469495 1393234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667700 1667700 1580993 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668555 1668555 1581848 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2509046 2509046 2371381 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 133203297 c.1652C>T p.P551L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 62 ENSP00000415559.1:p.Pro551Leu ENST00000455089.5:c.1652C>T 7:g.55165344C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450935 1450935 1375078 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 82 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042900 1042900 959241 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2476856 2476856 2339625 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027722 2027722 1909625 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422824 2422824 2285746 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2076950 2076950 1955699 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24369725 pleural effusion recurrent 57 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594127 1594127 1515050 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724887 surgery fresh/frozen NS 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1994270 1994270 1879525 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23886169 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1590996 1590996 1512112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2148635 2148635 2017765 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1774678 1774678 1678902 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22993320 surgery - NOS recurrent 76 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096284 2096284 1974348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2093907 2093907 1972115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24453288 surgery - NOS NS 67 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2664347 2664347 2524416 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 50 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1450936 1450936 1375079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 77 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1551500 1551500 1473605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 1551500 1551500 1473605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2000183 2000183 1885081 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875806 1875806 1766389 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1000816 1000816 918039 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 16983123 autopsy - NOS metastasis 53 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778774 2778774 2636828 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 4979 915961 833360 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51790353 COSM13178 132609832 c.1946C>T p.P649L Substitution - Missense 38 7:55173940-55173940 + - PATHOGENIC .97388 Variant of unknown origin 16014883 surgery-fixed NS ENSP00000395243.3:p.Pro649Leu ENST00000454757.6:c.1946C>T 7:g.55173940C>T EGFR ENST00000275493.6 3633 3236 1479079 1479079 1402772 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083355 1083355 998520 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17596643 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2073885 2073885 1953051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24370197 NS NS 46 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1120920 1120920 1034076 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096177 2096177 1974241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 899310 899310 816922 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924335 924335 841110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879511 1879511 1770013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2486050 2486050 2348699 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27013585 surgery - NOS primary 57 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1635454 1635454 1551959 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 22333554 surgery-fixed metastasis 62 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2115428 2115428 1989672 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 23915069 surgery - NOS NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1891296 1891296 1780665 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895168 1895168 1783860 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1135417 1135417 1047981 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891200 1891200 1780569 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1986157 1986157 1872393 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1434739 1434739 1344097 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20813423 surgery - NOS primary 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838675 1838675 1732776 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136865 1136865 1049429 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043853 1043853 960194 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1197351 1197351 1109246 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1046999 1046999 963230 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089607 1089607 1004554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860424 1860424 1751365 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1876997 1876997 1767559 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1052738 1052738 968809 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17368623 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453495 1453495 1377528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1549822 1549822 1471927 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891278 1891278 1780647 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895167 1895167 1783859 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450943 1450943 1375086 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CT19 1063199 979244 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-91-6835-01 1780237 1684236 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 81 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897801 897801 815423 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226773 2226773 2094508 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51823614 COSM4170219 133202511 c.2120C>T p.S707F Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98332 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Ser707Phe ENST00000455089.5:c.2120C>T 7:g.55174792C>T EGFR ENST00000275493.6 3633 3236 2118425 2118425 1992660 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1097638 1097638 1012299 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770568 1770568 1674808 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885192 1885192 1775079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095926 2095926 1973990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587200 1587200 1508371 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345408 2345408 2210080 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476856 2476856 2339625 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838724 1838724 1732825 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914928 1914928 1802930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770648 1770648 1674888 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921932 1921932 1809250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535027 1535027 1457362 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551548 1551548 1473653 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264276 2264276 2131260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096089 2096089 1974153 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000155 2000155 1885053 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874738 1874738 1765329 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096153 2096153 1974217 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1434751 1434751 1344109 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20813423 surgery - NOS primary 83 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960165 1960165 1846805 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029002 2029002 1910884 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014080 1014080 931254 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264299 2264299 2131283 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136884 1136884 1049448 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1135422 1135422 1047986 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1610918 1610918 1530146 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22157931 surgery-fixed primary 55 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875370 1875370 1765953 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895079 1895079 1783771 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862715 2862715 2717878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983827 1983827 1870063 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-RT-S01771 1765129 1669449 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 48 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1648544 1648544 1563499 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1534106 1534106 1456445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21707848 surgery-fixed primary 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1197353 1197353 1109248 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1135420 1135420 1047984 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1046996 1046996 963227 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1625791 1625791 1543015 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1237698 1237698 1149445 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618691 1618691 1537443 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118430 2118430 1992665 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1154306 1154306 1066642 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18957054 surgery-fixed NS 48 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469471 1469471 1393210 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493346 1493346 1416336 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148635 2148635 2017765 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838556 1838556 1732657 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637204 1637204 1553252 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173394 1173394 1085478 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525678 2525678 2387867 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1523392 1523392 1445764 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21626329 surgery-fixed recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214548 2214548 2082672 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095933 2095933 1973997 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637112 1637112 1553160 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226153 2226153 2093888 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777247 1777247 1681250 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587289 1587289 1508460 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638745 1638745 1554744 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770592 1770592 1674832 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045959 2045959 1926254 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2406813 2406813 2269693 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914940 1914940 1802942 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770633 1770633 1674873 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1635373 1635373 1551878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22335887 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045987 2045987 1926282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000159 2000159 1885057 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921729 1921729 1809047 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense hom + - Reported in another cancer sample as somatic 23620765 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1675618 1675618 1588498 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22560922 surgery-fixed metastasis 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542151 1542151 1464454 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2406817 2406817 2269697 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2131928 2131928 2005991 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24376723 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1661843 1661843 1575456 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22487432 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2093907 2093907 1972115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24453288 surgery - NOS NS 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983101 983101 898819 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680747 2680747 2540020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237668 1237668 1149415 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083814 1083814 998979 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237689 1237689 1149436 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345480 2345480 2210152 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081998 2081998 1960420 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24443522 surgery - NOS NS 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664347 2664347 2524416 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 50 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-197-tumor 2819082 2675381 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00278T00278 2857364 2712664 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00305T00305 2857328 2712628 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899351 899351 816963 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2214562 2214562 2082686 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2562089 2562089 2423485 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547799 1547799 1469921 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed metastasis 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551540 1551540 1473645 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1053131 1053131 969202 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17409961 surgery - NOS NS 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770530 1770530 1674770 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336845 1336845 1247230 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2069200 2069200 1948775 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24346091 NS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937508 1937508 1824442 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731105 1731105 1637076 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22815900 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1635454 1635454 1551959 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22333554 surgery-fixed metastasis 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345432 2345432 2210104 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 999924 999924 917147 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16785471 surgery - NOS primary 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770511 1770511 1674751 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475376 1475376 1399075 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2733228 2733228 2591981 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 133203297 c.1652C>T p.P551L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 61 ENSP00000415559.1:p.Pro551Leu ENST00000455089.5:c.1652C>T 7:g.55165344C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103764 1103764 1018016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 72 ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103764 1103764 1018016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 72 ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00426T00426 2857346 2712646 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2595749 2595749 2456625 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1610965 1610965 1530193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22157369 surgery-fixed metastasis 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664356 2664356 2524420 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 44 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2664356 2664356 2524420 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 44 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986153 1986153 1872389 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983714 1983714 1869950 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983713 1983713 1869949 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1705520 1705520 1613426 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1098857 1098857 1013449 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1593009 1593009 1513935 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1566942 1566942 1488711 upper_aerodigestive_tract pharynx oropharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 21953075 surgery fresh/frozen primary ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2078361 2078361 1957080 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24314215 pleural effusion NS 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895144 1895144 1783836 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 C331 2897780 2752079 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV99296441 COSM9178873 132577293 c.2908G>A p.E970K Substitution - Missense 38 7:55201284-55201284 + - PATHOGENIC .99529 Variant of unknown origin 31477716 surgery-fixed NS 73 ENSP00000395243.3:p.Glu970Lys ENST00000454757.6:c.2908G>A 7:g.55201284G>A EGFR ENST00000275493.6 3633 3236 899337 899337 816949 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1083994 1083994 999159 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17785547 surgery fresh/frozen primary 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983719 1983719 1869955 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450922 1450922 1375065 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 52 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1714998 1714998 1622577 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22710815 surgery-fixed primary 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891182 1891182 1780551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1627723 1627723 1544635 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891286 1891286 1780655 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1077344 1077344 992598 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450940 1450940 1375083 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2110149 2110149 1986501 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24563335 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1456558 1456558 1380533 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1964336 1964336 1850871 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891194 1891194 1780563 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1077331 1077331 992585 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1627726 1627726 1544638 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DCR10 1690659 1598936 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 133216830 c.1341C>A p.S447R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000415559.1:p.Ser447Arg ENST00000455089.5:c.1341C>A 7:g.55160316C>A EGFR ENST00000275493.6 3633 3236 1983759 1983759 1869995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899333 899333 816945 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983785 1983785 1870021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891218 1891218 1780587 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2372594 2372594 2235387 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1576783 1576783 1498224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 63 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1895064 1895064 1783756 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 BL-17-K52205 2905639 2759895 NS NS NS NS malignant_melanoma NS NS NS n COSV51783368 COSM6196862 99394128 c.2221C>T p.P741S Substitution - Missense 38 7:55174758-55174758 + - PATHOGENIC .99382 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Pro741Ser ENST00000275493.6:c.2221C>T 7:g.55174758C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875374 1875374 1765957 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136876 1136876 1049440 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895101 1895101 1783793 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042909 1042909 959250 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899329 899329 816941 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1083997 1083997 999162 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17785547 surgery fresh/frozen primary 52 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PC-9 946058 862584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043856 1043856 960197 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2579643 2579643 2440980 NS NS NS NS malignant_melanoma NS NS NS n COSV51815916 COSM28600 132564415 c.1960C>T p.P654S Substitution - Missense 38 7:55173954-55173954 + - PATHOGENIC .97389 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000395243.3:p.Pro654Ser ENST00000454757.6:c.1960C>T 7:g.55173954C>T EGFR ENST00000275493.6 3633 3236 2007941 2007941 1890676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 99378340 c.2248G>C p.A750P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Reported in another cancer sample as somatic 23907151 fine needle aspirate metastasis ENSP00000275493.2:p.Ala750Pro ENST00000275493.6:c.2248G>C 7:g.55174785G>C EGFR ENST00000275493.6 3633 3236 1879566 1879566 1770068 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920133 920133 837213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895086 1895086 1783778 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895104 1895104 1783796 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631959 1631959 1548829 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-38-4627-01 1780091 1684090 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 21 1433986 1343401 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2474440 2474440 2337209 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1635450 1635450 1551955 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22333554 surgery-fixed primary 79 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1635450 1635450 1551955 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22333554 surgery-fixed primary 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203099 2203099 2071357 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264254 2264254 2131238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1532692 1532692 1455052 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 20925915 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1637229 1637229 1553277 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345524 2345524 2210196 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891296 1891296 1780665 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2264285 2264285 2131269 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096146 2096146 1974210 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345592 2345592 2210264 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980077 1980077 1866320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 44 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897813 897813 815435 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895139 1895139 1783831 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302289 1302289 1213340 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1310474 1310474 1221419 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-G34953 2905427 2759683 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51788796 COSM4680390 133226922 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000415559.1:p.Arg98Gln ENST00000455089.5:c.293G>A 7:g.55143357G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 18 2570181 2431478 skin face NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51773206 COSM28603 133217070 c.2158G>A p.V720M Substitution - Missense 38 7:55181302-55181302 + - PATHOGENIC .97963 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 53 ENSP00000415559.1:p.Val720Met ENST00000455089.5:c.2158G>A 7:g.55181302G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675161 2675161 2534435 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51794723 COSM6849767 132557771 c.2077G>T p.V693F Substitution - Missense 38 7:55174749-55174749 + - PATHOGENIC .99674 Variant of unknown origin 29075127 surgery fresh/frozen NS ENSP00000395243.3:p.Val693Phe ENST00000454757.6:c.2077G>T 7:g.55174749G>T EGFR ENST00000275493.6 3633 3236 1842969 1842969 1736217 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1162976 1162976 1075299 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 18992959 NS recurrent 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1329255 1329255 1239740 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1043861 1043861 960202 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1965902 1965902 1852395 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009149 2009149 1891883 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924337 924337 841112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1000058 1000058 917281 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1355108 1355108 1265203 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014241 1014241 931415 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fresh/frozen - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1312891 1312891 1223800 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19884861 blood-bone marrow NS 73 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264420 2264420 2131404 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2028993 2028993 1910875 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1481238 1481238 1404867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2026254 2026254 1908343 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2732935 2732935 2591688 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 72 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 1450880 1450880 1375023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592872 1592872 1513798 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51807743 COSM133179 133222581 c.1930G>A p.V644M Substitution - Missense 38 7:55173924-55173924 + - PATHOGENIC .9843 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Val644Met ENST00000455089.5:c.1930G>A 7:g.55173924G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001303-T03-IM5 2719408 2578229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51807743 COSM133179 133222581 c.1930G>A p.V644M Substitution - Missense het 38 7:55173924-55173924 + - PATHOGENIC .9843 Reported in another cancer sample as somatic 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Val644Met ENST00000455089.5:c.1930G>A 7:g.55173924G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2688938 2688938 2547920 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 29245278 surgery - NOS metastasis 59 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2218429 2218429 2086440 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25076890 surgery - NOS metastasis 79 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2151463 2151463 2020492 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24742923 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618833 1618833 1537585 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 429-28 2605260 2466151 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25376516 surgery - NOS NS 51 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2106533 2106533 1984396 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246695 1246695 1158374 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043871 1043871 960212 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897833 897833 815455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983715 1983715 1869951 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895107 1895107 1783799 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453423 1453423 1377456 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924525 924525 841298 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895136 1895136 1783828 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983735 1983735 1869971 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1500180 1500180 1423059 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895092 1895092 1783784 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302278 1302278 1213329 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891192 1891192 1780561 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096297 2096297 1974361 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096297 2096297 1974361 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008797 2008797 1891531 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1838657 1838657 1732758 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1892631 1892631 1781883 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23566546 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2161695 2161695 2030302 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24813888 surgery fresh/frozen recurrent 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2161695 2161695 2030302 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 24813888 surgery fresh/frozen recurrent 58 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1649512 1649512 1564299 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22386733 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469865 1469865 1393604 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469865 1469865 1393604 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891195 1891195 1780564 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1992093 1992093 1877410 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 77 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 BL-14-R46791 2905653 2759909 NS NS NS NS malignant_melanoma NS NS NS n COSV51844648 COSM6971178 99383021 c.820A>G p.T274A Substitution - Missense 38 7:55154083-55154083 + - PATHOGENIC .96224 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000275493.2:p.Thr274Ala ENST00000275493.6:c.820A>G 7:g.55154083A>G EGFR ENST00000275493.6 3633 3236 MG-275-tumor 2819122 2675421 meninges NS NS NS meningioma anaplastic NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1992090 1992090 1877407 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 63 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1576797 1576797 1498238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 66 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005356 1005356 922568 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983828 1983828 1870064 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089135 1089135 1004089 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2095938 2095938 1974002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027785 2027785 1909688 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1523395 1523395 1445767 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21626329 surgery-fixed recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1075909 1075909 991163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875364 1875364 1765947 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2076209 2076209 1955021 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24406864 surgery-fixed primary 38 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-RT-S01702 1765245 1669565 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51797291 COSM379422 132586797 c.1762C>T p.L588F Substitution - Missense 38 7:55171191-55171191 + - PATHOGENIC .94672 Variant of unknown origin 22980975 surgery - NOS primary 60 ENSP00000395243.3:p.Leu588Phe ENST00000454757.6:c.1762C>T 7:g.55171191C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891256 1891256 1780625 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1672195 1672195 1585383 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21917678 fine needle aspirate NS 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 946829 946829 863352 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51778659 COSM14070 132547729 c.2453G>A p.G818D Substitution - Missense 38 7:55191837-55191837 + - PATHOGENIC .92688 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000395243.3:p.Gly818Asp ENST00000454757.6:c.2453G>A 7:g.55191837G>A EGFR ENST00000275493.6 3633 3236 1278201 1278201 1189499 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862074 2862074 2717281 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 32122695 surgery - NOS NS 62 ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1566946 1566946 1488715 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51804843 COSM12429 132553900 c.2438_2439delinsGT p.L813R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 21953075 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438_2439delinsGT 7:g.55191822_55191823delinsGT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1751717 1751717 1656533 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895076 1895076 1783768 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 11-18-GEF20-1 1731376 1637342 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22815900 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042916 1042916 959257 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 946828 946828 863351 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51804843 COSM12429 132553900 c.2438_2439delinsGT p.L813R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438_2439delinsGT 7:g.55191822_55191823delinsGT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1575157 1575157 1496598 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879517 1879517 1770019 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1715000 1715000 1622579 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22710815 surgery-fixed primary 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1046997 1046997 963228 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2509044 2509044 2371379 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 49 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 1093897 1093897 1008599 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18061305 pleural effusion NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2148629 2148629 2017759 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964331 1964331 1850866 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1672451 1672451 1585505 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21729655 surgery-fixed metastasis 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879578 1879578 1770080 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875357 1875357 1765940 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1140943 1140943 1053391 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448998 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1000060 1000060 917283 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879530 1879530 1770032 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DH402C 2762552 2620811 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51780730 COSM22940 133206317 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 29615459 NS primary 65 ENSP00000415559.1:p.Arg731His ENST00000455089.5:c.2192G>A 7:g.55181336G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1456555 1456555 1380530 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983767 1983767 1870003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891292 1891292 1780661 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891274 1891274 1780643 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5356 915976 833375 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51794784 COSM13182 132548944 c.2068G>A p.G690S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000395243.3:p.Gly690Ser ENST00000454757.6:c.2068G>A 7:g.55174740G>A EGFR ENST00000275493.6 3633 3236 1042911 1042911 959252 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1853103 1853103 1745718 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 23313172 surgery-fixed NS 48 ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1853103 1853103 1745718 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51777782 COSM6227 132554599 c.2369A>T p.H790L Substitution - Missense het 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 23313172 surgery-fixed NS 48 ENSP00000395243.3:p.His790Leu ENST00000454757.6:c.2369A>T 7:g.55191753A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-NYU696 1765167 1669487 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 57 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659806 2659806 2519964 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891220 1891220 1780589 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897823 897823 815445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2076938 2076938 1955687 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24369725 surgery-fixed recurrent 48 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2076938 2076938 1955687 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed recurrent 48 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1043866 1043866 960207 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2345794 2345794 2210466 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638726 1638726 1554725 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345105 2345105 2209777 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1246618 1246618 1158297 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1981025 1981025 1867261 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1031908 1031908 948699 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17085664 pleural effusion recurrent ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879534 1879534 1770036 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1078215 1078215 993465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767677 COSM25016 132554273 c.2200G>A p.G734S Substitution - Missense 38 7:55181344-55181344 + - PATHOGENIC .98244 Reported in another cancer sample as somatic 17626639 surgery-fixed metastasis ENSP00000395243.3:p.Gly734Ser ENST00000454757.6:c.2200G>A 7:g.55181344G>A EGFR ENST00000275493.6 3633 3236 2425719 2425719 2288640 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996941 1996941 1882150 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM24429 178380423 c.? p.E709G Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 59 ENSP00000275493.2:p.Glu709Gly EGFR ENST00000275493.6 3633 3236 1996941 1996941 1882150 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535031 1535031 1457366 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879238 1879238 1769793 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 23468066 fine needle aspirate NS 81 ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1295349 1295349 1206428 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 19884551 surgery fresh/frozen NS ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 1879427 1879427 1769932 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23464964 surgery-fixed NS 70 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1966313 1966313 1852806 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345558 2345558 2210230 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-061-tumor 2819000 2675299 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226882 2226882 2094617 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897845 897845 815467 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1188173 1188173 1100072 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19253367 surgery-fixed primary 43 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891196 1891196 1780565 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1675624 1675624 1588504 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22560922 surgery-fixed primary 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1202553 1202553 1114439 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1965896 1965896 1852389 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2652475 2652475 2512602 breast NS NS NS carcinoma HER-positive_carcinoma NS NS n COSM6503280 178380263 c.? p.K846R Substitution - Missense + - Reported in another cancer sample as somatic 28750640 surgery-fixed NS ENSP00000275493.2:p.Lys846Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1576792 1576792 1498233 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 surgery - NOS metastasis 56 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1542176 1542176 1464479 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2007943 2007943 1890678 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 99378340 c.2248G>C p.A750P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Reported in another cancer sample as somatic 23907151 fine needle aspirate metastasis ENSP00000275493.2:p.Ala750Pro ENST00000275493.6:c.2248G>C 7:g.55174785G>C EGFR ENST00000275493.6 3633 3236 2096010 2096010 1974074 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862244 2862244 2717434 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25969368 surgery-fixed primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1891314 1891314 1780683 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 1661375 1661375 1574990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 22483783 surgery-fixed NS 82 ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 1355106 1355106 1265201 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1882243 1882243 1772394 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23392229 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881376 1881376 1771527 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895145 1895145 1783837 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1876994 1876994 1767556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879547 1879547 1770049 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631946 1631946 1548816 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1517072 1517072 1439666 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226180 2226180 2093915 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637705 2637705 2498078 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770683 1770683 1674923 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878855 2878855 2733370 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27368130 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875806 1875806 1766389 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077341 1077341 992595 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2843208 2843208 2698661 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS n COSV51801471 COSM53105 132553118 c.2357G>A p.R786H Substitution - Missense 38 7:55191741-55191741 + - PATHOGENIC .96289 Reported in another cancer sample as somatic 25302557 blood-bone marrow NS ENSP00000395243.3:p.Arg786His ENST00000454757.6:c.2357G>A 7:g.55191741G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2808101 2808101 2664786 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 31258848 surgery-fixed NS 60 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 TCGA-38-4627-01 1780091 1684090 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 64 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 1336836 1336836 1247221 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 LUAD-RT-S01810 1765179 1669499 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51809160 COSM382935 99378402 c.1606G>A p.V536M Substitution - Missense 38 7:55161606-55161606 + - PATHOGENIC .98051 Reported in another cancer sample as somatic 22980975 surgery - NOS primary ENSP00000275493.2:p.Val536Met ENST00000275493.6:c.1606G>A 7:g.55161606G>A EGFR ENST00000275493.6 3633 3236 BL-17-G34953 2905427 2759683 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51788796 COSM4680390 99401501 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000275493.2:p.Arg98Gln ENST00000275493.6:c.293G>A 7:g.55143357G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DM2 2466860 2329691 skin face NS NS malignant_melanoma desmoplastic NS NS n COSV51800313 COSM5608354 133204795 c.2137G>A p.E713K Substitution - Missense 38 7:55174809-55174809 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 26343386 surgery-fixed NS 86 ENSP00000415559.1:p.Glu713Lys ENST00000455089.5:c.2137G>A 7:g.55174809G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453412 1453412 1377445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453412 1453412 1377445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2426840 2426840 2289761 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2862405 2862405 2717591 lung right_lower_lobe NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 31561203 surgery - NOS metastasis 76 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618658 1618658 1537410 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 76 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2664372 2664372 2524428 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 45 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481240 1481240 1404869 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2665265 2665265 2524988 lung left_lower_lobe NS NS carcinoma adenocarcinoma transformed_to_small_cell_carcinoma NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 28723866 circulating tumour recurrent 37 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2824226 2824226 2680045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 31542322 surgery - NOS recurrent 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1601927 1601927 1521415 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22108465 surgery-fixed metastasis 64 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2153114 2153114 2022124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2664334 2664334 2524409 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 63 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1707040 1707040 1614946 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22695392 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1551480 1551480 1473585 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891263 1891263 1780632 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1638736 1638736 1554735 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DM2 2466860 2329691 skin face NS NS malignant_melanoma desmoplastic NS NS n COSV51781503 COSM5608352 133226045 c.1774C>T p.P592S Substitution - Missense 38 7:55171203-55171203 + - NEUTRAL .1586 Reported in another cancer sample as somatic 26343386 surgery-fixed NS 86 ENSP00000415559.1:p.Pro592Ser ENST00000455089.5:c.1774C>T 7:g.55171203C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1000061 1000061 917284 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 57 2760165 2618698 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51780766 COSM219795 133202085 c.2456C>T p.A819V Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .93098 Reported in another cancer sample as somatic 29876005 surgery-fixed NS ENSP00000415559.1:p.Ala819Val ENST00000455089.5:c.2456C>T 7:g.55191840C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983755 1983755 1869991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2147915 2147915 2017058 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 79 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110463 1110463 1024341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00229T00229 2857347 2712647 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MBC067T 2807243 2663947 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99294040 COSM9120802 132563454 c.379G>A p.A127T Substitution - Missense 38 7:55143443-55143443 + - NEUTRAL .01752 Reported in another cancer sample as somatic 31340200 surgery - NOS NS ENSP00000395243.3:p.Ala127Thr ENST00000454757.6:c.379G>A 7:g.55143443G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675683 2675683 2534957 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136873 1136873 1049437 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239186 2239186 2106718 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 76 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1881373 1881373 1771524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2432374 2432374 2295277 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 26473643 surgery fresh/frozen metastasis 59 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 BL-16-A36234 2905681 2759937 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 1585339 1585339 1506660 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22011666 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1278193 1278193 1189491 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1450935 1450935 1375078 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 82 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042900 1042900 959241 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862770 2862770 2717933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 133216269 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + - PATHOGENIC .95568 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064714 2064714 1944791 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983700 1983700 1869936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777346 1777346 1681349 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1668555 1668555 1581848 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2509046 2509046 2371381 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 99374883 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 62 ENSP00000275493.2:p.Pro596Leu ENST00000275493.6:c.1787C>T 7:g.55165344C>T EGFR ENST00000275493.6 3633 3236 1542162 1542162 1464465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983142 983142 898860 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2733228 2733228 2591981 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 99374883 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 61 ENSP00000275493.2:p.Pro596Leu ENST00000275493.6:c.1787C>T 7:g.55165344C>T EGFR ENST00000275493.6 3633 3236 1594127 1594127 1515050 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724887 surgery fresh/frozen NS 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2905779 2905779 2760031 meninges NS NS NS meningioma NS NS NS n COSM34166 178380439 c.? p.R108K Substitution - Missense + - Reported in another cancer sample as somatic 31872418 surgery - NOS NS ENSP00000275493.2:p.Arg108Lys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-RT-S01810 1765179 1669499 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51809160 COSM382935 133206494 c.1471G>A p.V491M Substitution - Missense 38 7:55161606-55161606 + - PATHOGENIC .98051 Reported in another cancer sample as somatic 22980975 surgery - NOS primary ENSP00000415559.1:p.Val491Met ENST00000455089.5:c.1471G>A 7:g.55161606G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983831 1983831 1870067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891173 1891173 1780542 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983770 1983770 1870006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920134 920134 837214 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 51 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-02-0023-01 1910131 1798422 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 38 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2421206 2421206 2284128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1077371 1077371 992625 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2757126 2757126 2615769 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 99375713 c.2318A>T p.H773L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 29858019 circulating tumour recurrent 50 ENSP00000275493.2:p.His773Leu ENST00000275493.6:c.2318A>T 7:g.55181327A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924346 924346 841121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2076210 2076210 1955022 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51767182 COSM27110 133210338 c.2221G>A p.V741M Substitution - Missense het 38 7:55181365-55181365 + - PATHOGENIC .97319 Reported in another cancer sample as somatic 24406864 surgery-fixed primary 87 ENSP00000415559.1:p.Val741Met ENST00000455089.5:c.2221G>A 7:g.55181365G>A EGFR ENST00000275493.6 3633 3236 LUAD-RT-S01771 1765129 1669449 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51780730 COSM22940 99378223 c.2327G>A p.R776H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 48 ENSP00000275493.2:p.Arg776His ENST00000275493.6:c.2327G>A 7:g.55181336G>A EGFR ENST00000275493.6 3633 3236 2096231 2096231 1974295 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 V80 1179749 1091711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 79 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067075 1067075 983055 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602799 1602799 1522135 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983777 1983777 1870013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983733 1983733 1869969 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983830 1983830 1870066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602800 1602800 1522136 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479940 1479940 1403600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1694969 1694969 1603189 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 49 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1032022 1032022 948813 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17060940 pleural effusion NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983727 1983727 1869963 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1567520 1567520 1489152 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21949883 fine needle aspirate metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1456576 1456576 1380551 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1107248 1107248 1021160 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891336 1891336 1780705 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899336 899336 816948 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593022 1593022 1513948 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043854 1043854 960195 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 MG-162-tumor 2819060 2675359 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0002PT00038T00038 2857332 2712632 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895141 1895141 1783833 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453413 1453413 1377446 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862090 2862090 2717292 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 G36 1063244 979289 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891262 1891262 1780631 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 109610 2812911 2669325 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 16 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2897034 2897034 2751372 ovary NS NS NS germ_cell_tumour mixed malignant NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 30349318 surgery - NOS NS 34 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983752 1983752 1869988 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879501 1879501 1770003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1996547 1996547 1881756 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Reported in another cancer sample as somatic 23922984 surgery-fixed NS ENSP00000275493.2:p.Leu861Arg EGFR ENST00000275493.6 3633 3236 NPC0001PT00346T00346 2857341 2712641 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00192T00192 2857326 2712626 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1246685 1246685 1158364 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549125 2549125 2410580 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 924335 924335 841110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1505479 1505479 1428348 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21422426 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875687 1875687 1766270 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551560 1551560 1473665 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879553 1879553 1770055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1523013 1523013 1445385 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 60 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2819295 2819295 2675594 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 30711944 pleural effusion recurrent 63 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879536 1879536 1770038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2218428 2218428 2086439 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25076890 surgery - NOS primary 79 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593014 1593014 1513940 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231317 1231317 1143107 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226918 2226918 2094653 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PR-0099 1691496 1599763 prostate NS NS NS carcinoma NS NS NS y COSV51846648 COSM244213 132558577 c.2246C>A p.P749H Substitution - Missense het 38 7:55181390-55181390 + - PATHOGENIC .97291 Reported in another cancer sample as somatic 22610119 surgery fresh/frozen primary 70 ENSP00000395243.3:p.Pro749His ENST00000454757.6:c.2246C>A 7:g.55181390C>A EGFR ENST00000275493.6 3633 3236 907081 1007166 924374 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 16638863 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2026238 2026238 1908327 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2148645 2148645 2017775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2046645 2046645 1926939 lung NS NS NS carcinoma NS NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064721 2064721 1944798 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668461 1668461 1581754 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602809 1602809 1522145 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 HCC4006 2776305 2634441 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51830861 COSM6219 133206440 c.2113G>C p.A705P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Reported in another cancer sample as somatic 29681454 NS NS ENSP00000415559.1:p.Ala705Pro ENST00000455089.5:c.2113G>C 7:g.55174785G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895109 1895109 1783801 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469869 1469869 1393608 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618055 1618055 1536851 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2437220 2437220 2300070 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26469914 surgery - NOS metastasis 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346541 2346541 2211204 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096128 2096128 1974192 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637111 1637111 1553159 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475388 1475388 1399087 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2426840 2426840 2289761 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203087 2203087 2071345 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862405 2862405 2717591 lung right_lower_lobe NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31561203 surgery - NOS metastasis 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1532694 1532694 1455054 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20925915 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637174 1637174 1553222 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345418 2345418 2210090 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777398 1777398 1681401 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618658 1618658 1537410 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218541 2218541 2086552 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1696874 1696874 1605002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22674612 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965828 1965828 1852321 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2486053 2486053 2348702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27013585 surgery - NOS primary 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218526 2218526 2086537 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008931 2008931 1891665 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22391431 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522892 1522892 1445264 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770551 1770551 1674791 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345573 2345573 2210245 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345477 2345477 2210149 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444770 1444770 1369013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230452 1230452 1142266 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345434 2345434 2210106 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203093 2203093 2071351 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1112970 1112970 1026481 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448997 surgery-fixed NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174313 1174313 1086332 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618863 1618863 1537615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2560134 2560134 2421558 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26826182 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1000815 1000815 918038 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 16983123 autopsy - NOS metastasis 53 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2479709 2479709 2342455 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1237681 1237681 1149428 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1154309 1154309 1066645 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18957054 surgery-fixed NS 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777218 1777218 1681221 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838680 1838680 1732781 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937538 1937538 1824472 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777419 1777419 1681422 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264241 2264241 2131225 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 924460 924460 841235 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16198442 surgery - NOS primary 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729986 1729986 1635957 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 H1975 1802294 1704013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23136191 cell-line NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914892 1914892 1802894 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1997146 1997146 1882355 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23930206 fixed - NOS primary 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887427 1887427 1777099 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2028991 2028991 1910873 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914906 1914906 1802908 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230453 1230453 1142267 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1823851 1823851 1722245 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23212424 surgery-fixed primary 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226174 2226174 2093909 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777290 1777290 1681293 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278195 1278195 1189493 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264123 2264123 2131107 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618774 1618774 1537526 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637191 1637191 1553239 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887403 1887403 1777075 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2245039 2245039 2112315 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522890 1522890 1445262 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026238 2026238 1908327 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096016 2096016 1974080 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345795 2345795 2210467 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203086 2203086 2071344 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444762 1444762 1369005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336426 1336426 1246811 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20430469 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770688 1770688 1674928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921940 1921940 1809258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095911 2095911 1973975 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1837419 1837419 1731618 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23242437 NS NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345603 2345603 2210275 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045976 2045976 1926271 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921730 1921730 1809048 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense hom + - Reported in another cancer sample as somatic 23620765 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705462 1705462 1613368 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027794 2027794 1909697 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1963282 1963282 1849830 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23599349 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-14-R46791 2905653 2759909 NS NS NS NS malignant_melanoma NS NS NS n COSV51844648 COSM6971178 133211642 c.685A>G p.T229A Substitution - Missense 38 7:55154083-55154083 + - PATHOGENIC .96224 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000415559.1:p.Thr229Ala ENST00000455089.5:c.685A>G 7:g.55154083A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592977 1592977 1513903 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920137 920137 837217 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 44 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1931640 1931640 1818930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875384 1875384 1765967 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891333 1891333 1780702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891333 1891333 1780702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162182 1162182 1074514 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766284 COSM28512 132550675 c.2095A>G p.I699V Substitution - Missense 38 7:55174767-55174767 + - PATHOGENIC .99591 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000395243.3:p.Ile699Val ENST00000454757.6:c.2095A>G 7:g.55174767A>G EGFR ENST00000275493.6 3633 3236 1895168 1895168 1783860 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1675633 1675633 1588513 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22560922 surgery-fixed primary 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1135417 1135417 1047981 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1591006 1591006 1512122 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 109598 2812902 2669316 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 44 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1992092 1992092 1877409 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 54 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089599 1089599 1004546 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1174316 1174316 1086335 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1513414 1513414 1436075 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21497370 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1136865 1136865 1049429 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879542 1879542 1770044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2083098 2083098 1961519 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24300726 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637175 1637175 1553223 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665705 2665705 2525414 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS primary 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142066 2142066 2011284 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163043 2163043 2031627 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096012 2096012 1974076 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444577 1444577 1368822 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20686428 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986148 1986148 1872384 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664338 2664338 2524412 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336843 1336843 1247228 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1052968 1052968 969039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17410005 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2819302 2819302 2675601 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 30711944 pleural effusion recurrent 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469473 1469473 1393212 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1223900 1223900 1135732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19517135 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899357 899357 816969 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899357 899357 816969 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1618780 1618780 1537532 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1882246 1882246 1772397 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23392229 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2250134 2250134 2117393 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24990411 surgery-fixed NS 50 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226155 2226155 2093890 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246632 1246632 1158311 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1103764 1103764 1018016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 72 ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-081-tumor 2819015 2675314 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2205987 2205987 2074220 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 HN_62506 1560544 1481994 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51818237 COSM122787 99420630 c.534G>T p.M178I Substitution - Missense 38 7:55146715-55146715 + - PATHOGENIC .7306 Reported in another cancer sample as somatic 21798893 surgery fresh/frozen primary ENSP00000275493.2:p.Met178Ile ENST00000275493.6:c.534G>T 7:g.55146715G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-78-7155-01 1914061 1802343 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51802877 COSM6178050 132618172 c.2567G>T p.G856V Substitution - Missense 38 7:55198717-55198717 + - PATHOGENIC .9948 Variant of unknown origin 417 fresh/frozen - NOS primary 68 ENSP00000395243.3:p.Gly856Val ENST00000454757.6:c.2567G>T 7:g.55198717G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899354 899354 816966 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879238 1879238 1769793 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23468066 fine needle aspirate NS 81 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2862074 2862074 2717281 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 32122695 surgery - NOS NS 62 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1042854 1042854 959195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1591006 1591006 1512122 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891200 1891200 1780569 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1517391 1517391 1439775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21610522 cerebrospinal fluid metastasis 64 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302281 1302281 1213332 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1278400 1278400 1189696 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19596957 autopsy - NOS metastasis 51 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1469472 1469472 1393211 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046039 2046039 1926334 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2110146 2110146 1986498 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM86998 178379356 c.? p.R776C Substitution - Missense + - Reported in another cancer sample as somatic 24563335 surgery - NOS NS ENSP00000275493.2:p.Arg776Cys EGFR ENST00000275493.6 3633 3236 1770735 1770735 1674975 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162202 1162202 1074534 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1695229 1695229 1603449 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765351 COSM53292 132550377 c.2473C>T p.H825Y Substitution - Missense het 38 7:55191857-55191857 + - PATHOGENIC .96355 Reported in another cancer sample as somatic 22607702 surgery-fixed NS ENSP00000395243.3:p.His825Tyr ENST00000454757.6:c.2473C>T 7:g.55191857C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983773 1983773 1870009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1103764 1103764 1018016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 72 ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 2096157 2096157 1974221 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 NPC0001PT00426T00426 2857346 2712646 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1856152 1856152 1748705 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS primary ENSP00000275493.2:p.Glu709Lys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879556 1879556 1770058 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450920 1450920 1375063 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098873 1098873 1013465 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1 1077300 992554 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668466 1668466 1581759 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51795632 COSM26509 133221986 c.2092G>A p.A698T Substitution - Missense 38 7:55174764-55174764 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Ala698Thr ENST00000455089.5:c.2092G>A 7:g.55174764G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778532 2778532 2636586 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51859563 COSM6910210 132549516 c.2374G>A p.D792N Substitution - Missense 38 7:55191758-55191758 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000395243.3:p.Asp792Asn ENST00000454757.6:c.2374G>A 7:g.55191758G>A EGFR ENST00000275493.6 3633 3236 2136669 2136669 2006220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1140670 1140670 1053118 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 19238633 surgery-fixed metastasis 46 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659810 2659810 2519968 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2057657 2057657 1937864 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24255770 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593006 1593006 1513932 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1790526 1790526 1693505 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16152581 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-GE103-T1 2869807 2724804 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51789934 COSM6652266 132563344 c.3041C>T p.P1014L Substitution - Missense 38 7:55202530-55202530 + - PATHOGENIC .92486 Reported in another cancer sample as somatic 26950094 surgery - NOS NS 75 ENSP00000395243.3:p.Pro1014Leu ENST00000454757.6:c.3041C>T 7:g.55202530C>T EGFR ENST00000275493.6 3633 3236 1103639 1103639 1017891 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51795632 COSM26509 99395627 c.2227G>A p.A743T Substitution - Missense 38 7:55174764-55174764 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 81 ENSP00000275493.2:p.Ala743Thr ENST00000275493.6:c.2227G>A 7:g.55174764G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983707 1983707 1869943 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602812 1602812 1522148 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1355116 1355116 1265211 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983714 1983714 1869950 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264116 2264116 2131100 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077371 1077371 992625 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226862 2226862 2094597 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1695226 1695226 1603446 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51769837 COSM249780 132559442 c.2275G>A p.E759K Substitution - Missense 38 7:55181419-55181419 + - PATHOGENIC .97109 Variant of unknown origin 22607702 surgery-fixed NS ENSP00000395243.3:p.Glu759Lys ENST00000454757.6:c.2275G>A 7:g.55181419G>A EGFR ENST00000275493.6 3633 3236 1566942 1566942 1488711 upper_aerodigestive_tract pharynx oropharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 21953075 surgery fresh/frozen primary ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 1469817 1469817 1393556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2142062 2142062 2011280 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 924348 924348 841123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875339 1875339 1765922 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891174 1891174 1780543 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602819 1602819 1522155 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226905 2226905 2094640 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1625787 1625787 1543011 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226902 2226902 2094637 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1231323 1231323 1143113 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1166439 1166439 1078753 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 33 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1451204 1451204 1375347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1734963 1734963 1640907 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 49 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1135418 1135418 1047982 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895149 1895149 1783841 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1435996 1435996 1345275 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen NS 59 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1197367 1197367 1109262 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1668543 1668543 1581836 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1107249 1107249 1021161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895088 1895088 1783780 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2147914 2147914 2017057 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136864 1136864 1049428 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1860432 1860432 1751373 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1991299 1991299 1876634 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2076202 2076202 1955015 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 24389444 surgery-fixed NS 77 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064718 2064718 1944795 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983766 1983766 1870002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895116 1895116 1783808 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895148 1895148 1783840 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631958 1631958 1548828 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1200916 1200916 1112806 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2078361 2078361 1957080 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24314215 pleural effusion NS 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895144 1895144 1783836 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879572 1879572 1770074 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-46-3769-01 1781825 1685824 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51799159 COSM747427 133228317 c.1631C>T p.P544L Substitution - Missense 38 7:55165323-55165323 + - PATHOGENIC .95834 Reported in another cancer sample as somatic 418 fresh/frozen - NOS primary 57 ENSP00000415559.1:p.Pro544Leu ENST00000455089.5:c.1631C>T 7:g.55165323C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879499 1879499 1770001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1838701 1838701 1732802 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1823852 1823852 1722246 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23212424 surgery-fixed metastasis 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 916969 916969 834350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16052537 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964321 1964321 1850856 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000186 2000186 1885084 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345400 2345400 2210072 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230472 1230472 1142286 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096101 2096101 1974165 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1487183 1487183 1410793 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21317742 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2778774 2778774 2636828 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1000816 1000816 918039 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 16983123 autopsy - NOS metastasis 53 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2560101 2560101 2421525 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 26826182 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469795 1469795 1393534 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1981029 1981029 1867265 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422843 2422843 2285765 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1435994 1435994 1345273 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 20439191 surgery fresh/frozen NS 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469853 1469853 1393592 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2637648 2637648 2498021 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 54 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1964339 1964339 1850874 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746668 1746668 1651644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 78 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027736 2027736 1909639 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027820 2027820 1909723 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469818 1469818 1393557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2595754 2595754 2456630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1914887 1914887 1802889 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2264326 2264326 2131310 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637079 1637079 1553127 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1165594 1165594 1077908 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19050706 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 921169 921169 838128 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16002952 surgery-fixed primary 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203103 2203103 2071361 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937549 1937549 1824483 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1489662 1489662 1412820 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21155184 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875677 1875677 1766260 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1881379 1881379 1771530 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879506 1879506 1770008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-116-tumor 2819038 2675337 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1590990 1590990 1512106 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887369 1887369 1777041 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1024773 1024773 941750 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17020982 pleural effusion recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2157982 2157982 2026957 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828667 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096047 2096047 1974111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838670 1838670 1732771 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264358 2264358 2131342 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230465 1230465 1142279 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921883 1921883 1809201 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964309 1964309 1850844 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1512560 1512560 1435244 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21362302 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1167999 1167999 1080241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19059670 surgery-fixed primary 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046055 2046055 1926350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1707037 1707037 1614943 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22695392 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2560101 2560101 2421525 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26826182 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2110151 2110151 1986503 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24563335 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2644118 2644118 2504405 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230450 1230450 1142264 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664593 2664593 2524647 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28840008 surgery-fixed NS 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637710 2637710 2498083 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 circulating tumour recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770702 1770702 1674942 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885181 1885181 1775068 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542347 1542347 1464650 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770678 1770678 1674918 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011167 2011167 1893805 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774682 1774682 1678906 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS metastasis 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1733684 1733684 1639633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22836289 surgery-fixed NS 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095888 2095888 1973952 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921941 1921941 1809259 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881886 1881886 1772037 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983122 983122 898840 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493340 1493340 1416330 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1795775 1795775 1697523 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23110940 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000204 2000204 1885102 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 25 1596835 1517548 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20093389 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638742 1638742 1554741 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345539 2345539 2210211 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141328 1141328 1053776 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1523393 1523393 1445765 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21626329 surgery-fixed recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469380 1469380 1393119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246637 1246637 1158316 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422843 2422843 2285765 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921925 1921925 1809243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2406806 2406806 2269686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842992 1842992 1736240 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453417 1453417 1377450 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042856 1042856 959197 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1894920 1894920 1783612 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042856 1042856 959197 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 11 2570179 2431476 skin face NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51775222 COSM13189 133214176 c.2216C>T p.S739F Substitution - Missense 38 7:55181360-55181360 + - PATHOGENIC .94833 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 65 ENSP00000415559.1:p.Ser739Phe ENST00000455089.5:c.2216C>T 7:g.55181360C>T EGFR ENST00000275493.6 3633 3236 2549129 2549129 2410584 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542141 1542141 1464444 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345421 2345421 2210093 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025387 2025387 1907476 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469853 1469853 1393592 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230470 1230470 1142284 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667708 1667708 1581001 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174314 1174314 1086333 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770596 1770596 1674836 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665710 2665710 2525419 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS recurrent 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637225 1637225 1553273 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1707031 1707031 1614937 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22695392 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914953 1914953 1802955 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095982 2095982 1974046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214556 2214556 2082680 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106554 2106554 1984417 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2136679 2136679 2006230 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174327 1174327 1086346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026219 2026219 1908308 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1696866 1696866 1604994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22674612 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1668440 1668440 1581733 upper_aerodigestive_tract trachea NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22526156 surgery-fixed primary 8 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1593025 1593025 1513951 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1991359 1991359 1876694 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659798 2659798 2519956 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2676600 2676600 2535874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766331 COSM12366 133243522 c.2437C>A p.L813M Substitution - Missense 38 7:55191821-55191821 + - PATHOGENIC .93782 Reported in another cancer sample as somatic 28939152 NS NS 35 ENSP00000415559.1:p.Leu813Met ENST00000455089.5:c.2437C>A 7:g.55191821C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-RT-S01771 1765129 1669449 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51780730 COSM22940 133206317 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 48 ENSP00000415559.1:p.Arg731His ENST00000455089.5:c.2192G>A 7:g.55181336G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SA-N101 2521507 2383850 central_nervous_system spinal_cord NS NS glioma astrocytoma_Grade_II fibrillary NS n COSV51785554 COSM21688 132548847 c.836G>T p.R279L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Reported in another cancer sample as somatic 26487540 surgery-fixed NS 82 ENSP00000395243.3:p.Arg279Leu ENST00000454757.6:c.836G>T 7:g.55155911G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2290055 2290055 2156120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 16740761 surgery - NOS NS 81 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1444731 1444731 1368974 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096121 2096121 1974185 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591067 1591067 1512183 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885185 1885185 1775072 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887441 1887441 1777113 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1637268 1637268 1553316 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 HCC41T 1566756 1488563 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS n COSV51780707 COSM1251019 99400219 c.3458G>T p.S1153I Substitution - Missense het 38 7:55205442-55205442 + - NEUTRAL .36171 Reported in another cancer sample as somatic 323 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Ser1153Ile ENST00000275493.6:c.3458G>T 7:g.55205442G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194728 1194728 1106623 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-74TBW 1765218 1669538 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51853557 COSM355283 132554690 c.2925G>T p.Q975H Substitution - Missense 38 7:55201301-55201301 + - PATHOGENIC .88431 Variant of unknown origin 22980975 surgery - NOS primary 73 ENSP00000395243.3:p.Gln975His ENST00000454757.6:c.2925G>T 7:g.55201301G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983784 1983784 1870020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2479704 2479704 2342450 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592986 1592986 1513912 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2238937 2238937 2106469 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25137181 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 897813 897813 815435 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2822192 2822192 2678052 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 26373574 fixed - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1856152 1856152 1748705 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2069151 2069151 1948726 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24346091 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2809831 2809831 2666498 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31315676 circulating tumour recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774695 1774695 1678919 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS primary 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264273 2264273 2131257 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983118 983118 898836 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777293 1777293 1681296 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345478 2345478 2210150 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1795771 1795771 1697519 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23110940 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665717 2665717 2525426 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS primary 49 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1567592 1567592 1489224 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21949883 fine needle aspirate metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136881 1136881 1049445 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879500 1879500 1770002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879514 1879514 1770016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098869 1098869 1013461 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895094 1895094 1783786 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592963 1592963 1513889 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51854311 COSM133198 132563487 c.2108G>A p.R703K Substitution - Missense 38 7:55174780-55174780 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Arg703Lys ENST00000454757.6:c.2108G>A 7:g.55174780G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920129 920129 837209 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631957 1631957 1548827 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2757126 2757126 2615769 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 29858019 circulating tumour recurrent 50 ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980063 1980063 1866306 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 60 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1522949 1522949 1445321 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 74 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879539 1879539 1770041 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043125 1043125 959466 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 43 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875798 1875798 1766381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226867 2226867 2094602 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450929 1450929 1375072 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 84 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891201 1891201 1780570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1242316 1242316 1154046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19671738 surgery-fixed primary 56 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471796 1471796 1395534 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51770777 COSM28286 132563968 c.2359C>T p.R787C Substitution - Missense 38 7:55191743-55191743 + - PATHOGENIC .95135 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000395243.3:p.Arg787Cys ENST00000454757.6:c.2359C>T 7:g.55191743C>T EGFR ENST00000275493.6 3633 3236 1585329 1585329 1506650 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22011666 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1777333 1777333 1681336 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1498227 1498227 1421105 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21220471 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2142070 2142070 2011288 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479086 1479086 1402779 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141310 1141310 1053758 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PC-3 946056 862582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875379 1875379 1765962 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895123 1895123 1783815 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602820 1602820 1522156 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914809 914809 832258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042915 1042915 959256 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2479706 2479706 2342452 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 907088 907088 824600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005359 1005359 922571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 44 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983739 1983739 1869975 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990901 1990901 1876236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899325 899325 816937 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668542 1668542 1581835 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594594 1594594 1515562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453430 1453430 1377463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166438 1166438 1078752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 77 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005363 1005363 922575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 50 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103631 1103631 1017883 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891170 1891170 1780539 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-NYU252 1765120 1669440 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1882509 1882509 1772645 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51803731 COSM28604 132550372 c.2371C>T p.R791C Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .95213 Reported in another cancer sample as somatic 23486275 NS primary 81 ENSP00000395243.3:p.Arg791Cys ENST00000454757.6:c.2371C>T 7:g.55191755C>T EGFR ENST00000275493.6 3633 3236 1895139 1895139 1783831 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302289 1302289 1213340 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1310474 1310474 1221419 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2425746 2425746 2288667 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046609 2046609 1926903 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076209 2076209 1955021 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24406864 surgery-fixed primary 38 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-38-4627-01 1780091 1684090 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 64 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2757126 2757126 2615769 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 29858019 circulating tumour recurrent 50 ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1627724 1627724 1544636 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450924 1450924 1375067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-78-7155-01 1914061 1802343 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51802866 COSM1140059 132588903 c.2126A>T p.K709I Substitution - Missense 38 7:55174798-55174798 + - PATHOGENIC .99276 Variant of unknown origin 417 fresh/frozen - NOS primary 68 ENSP00000395243.3:p.Lys709Ile ENST00000454757.6:c.2126A>T 7:g.55174798A>T EGFR ENST00000275493.6 3633 3236 2637636 2637636 2498009 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 70 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2136661 2136661 2006212 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592996 1592996 1513922 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009145 2009145 1891879 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897810 897810 815432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 G36 1063244 979289 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 73 ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1107243 1107243 1021155 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429274 1429274 1338725 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226893 2226893 2094628 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1075909 1075909 991163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2549142 2549142 2410597 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096106 2096106 1974170 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2080631 2080631 1959185 oesophagus NS NS NS carcinoma small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24422746 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875364 1875364 1765947 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2000217 2000217 1885115 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 11-18-GEF20-1 1731376 1637342 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22815900 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00226T00226 2857365 2712665 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-185-tumor 2819071 2675370 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-087-tumor 2819019 2675318 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668440 1668440 1581733 upper_aerodigestive_tract trachea NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22526156 surgery-fixed primary 8 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593025 1593025 1513951 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 8LFG8F 2762947 2621206 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51839851 COSM7340115 133230540 c.983C>A p.P328Q Substitution - Missense 38 7:55156644-55156644 + - PATHOGENIC .76649 Reported in another cancer sample as somatic 29615459 NS metastasis 45 ENSP00000415559.1:p.Pro328Gln ENST00000455089.5:c.983C>A 7:g.55156644C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983772 1983772 1870008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110450 1110450 1024328 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 975329 975329 891197 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 16410744 surgery-fixed primary ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 11-18R 1890459 1779880 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22773810 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891270 1891270 1780639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1194728 1194728 1106623 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1166428 1166428 1078742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773206 COSM28603 99389206 c.2293G>A p.V765M Substitution - Missense het 38 7:55181302-55181302 + - PATHOGENIC .97963 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 67 ENSP00000275493.2:p.Val765Met ENST00000275493.6:c.2293G>A 7:g.55181302G>A EGFR ENST00000275493.6 3633 3236 2046180 2046180 1926475 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1672451 1672451 1585505 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21729655 surgery-fixed metastasis 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914805 914805 832254 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent 52 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1202562 1202562 1114448 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625549 2625549 2485961 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302288 1302288 1213339 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668473 1668473 1581766 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891211 1891211 1780580 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594592 1594592 1515560 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162204 1162204 1074536 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659808 2659808 2519966 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862711 2862711 2717874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862711 2862711 2717874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765252 COSM13009 133225791 c.1991A>G p.E664G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Glu664Gly ENST00000455089.5:c.1991A>G 7:g.55173985A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1694967 1694967 1603187 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 82 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1188175 1188175 1100074 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19253367 surgery-fixed primary 76 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-05-4410-01 1780064 1684063 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51823181 COSM6110421 132581616 c.996G>T p.R332S Substitution - Missense 38 7:55156657-55156657 + - NEUTRAL .42615 Variant of unknown origin 417 fresh/frozen - NOS primary 62 ENSP00000395243.3:p.Arg332Ser ENST00000454757.6:c.996G>T 7:g.55156657G>T EGFR ENST00000275493.6 3633 3236 2228275 2228275 2096005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2345568 2345568 2210240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895076 1895076 1783768 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 983095 983095 898813 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422780 2422780 2285702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1102461 1102461 1016713 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18202784 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136885 1136885 1049449 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51833668 COSM12675 132590886 c.2440G>A p.A814T Substitution - Missense 38 7:55191824-55191824 + - PATHOGENIC .98898 Variant of unknown origin 17580276 surgery-fixed primary ENSP00000395243.3:p.Ala814Thr ENST00000454757.6:c.2440G>A 7:g.55191824G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 12 1433977 1343392 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PC-13 946059 862585 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895102 1895102 1783794 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592993 1592993 1513919 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1882222 1882222 1772373 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 23392229 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2026150 2026150 1908239 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042905 1042905 959246 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2011178 2011178 1893816 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345410 2345410 2210082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592887 1592887 1513813 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1751716 1751716 1656532 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1107250 1107250 1021162 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1876987 1876987 1767549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875385 1875385 1765968 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103769 1103769 1018021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372592 2372592 2235385 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009159 2009159 1891893 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897847 897847 815469 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1083995 1083995 999160 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17785547 surgery fresh/frozen primary 83 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NCI-H1975 1047098 963329 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17332333 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899321 899321 816933 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2479707 2479707 2342453 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2057511 2057511 1937718 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24255770 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924341 924341 841116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1451206 1451206 1375349 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077335 1077335 992589 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625559 2625559 2485971 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51774247 COSM13008 132553412 c.2477C>G p.A826G Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .98497 Variant of unknown origin 27056568 surgery-fixed NS 51 ENSP00000395243.3:p.Ala826Gly ENST00000454757.6:c.2477C>G 7:g.55191861C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-17-W08054 2905635 2759891 urinary_tract NS NS NS carcinoma transitional_cell_carcinoma NS NS n COSV105863907 COSM9995468 132566276 c.1589G>A p.G530E Substitution - Missense 38 7:55165281-55165281 + - PATHOGENIC .99217 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000395243.3:p.Gly530Glu ENST00000454757.6:c.1589G>A 7:g.55165281G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136877 1136877 1049441 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 082-02-1TD 1921512 1808830 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51769737 COSM145359 99419486 c.3502G>A p.D1168N Substitution - Missense 38 7:55205486-55205486 + - PATHOGENIC .97139 Reported in another cancer sample as somatic 340 blood NS ENSP00000275493.2:p.Asp1168Asn ENST00000275493.6:c.3502G>A 7:g.55205486G>A EGFR ENST00000275493.6 3633 3236 1029000 1029000 945871 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 17075123 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2239167 2239167 2106699 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25130612 surgery - NOS NS 35 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2095951 2095951 1974015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2141444 2141444 2010662 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24636848 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879578 1879578 1770080 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1000060 1000060 917283 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879530 1879530 1770032 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-018-tumor 2818983 2675282 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00264T00264 2857327 2712627 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2027346 2027346 1909414 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 56 ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372596 2372596 2235389 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-78-7158-01 1914062 1802344 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51768921 COSM6178049 132609653 c.2584T>A p.L862M Substitution - Missense 38 7:55198734-55198734 + - NEUTRAL .38059 Variant of unknown origin 417 fresh/frozen - NOS primary 59 ENSP00000395243.3:p.Leu862Met ENST00000454757.6:c.2584T>A 7:g.55198734T>A EGFR ENST00000275493.6 3633 3236 2136680 2136680 2006231 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964343 1964343 1850878 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1166943 178385114 c.? p.V769L Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Val769Leu EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1434019 1434019 1343434 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924343 924343 841118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 921172 921172 838131 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense het + - Reported in another cancer sample as somatic 16002952 surgery-fixed primary 42 ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 2069648 2069648 1949053 skin NS NS NS malignant_melanoma acral_lentiginous NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22437319 surgery-fixed metastasis 73 ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862730 2862730 2717893 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2662907 2662907 2523029 kidney NS NS NS Wilms_tumour NS NS NS n COSV51778029 COSM6268 133209348 c.2122C>T p.P708S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 28326956 surgery-fixed NS ENSP00000415559.1:p.Pro708Ser ENST00000455089.5:c.2122C>T 7:g.55174794C>T EGFR ENST00000275493.6 3633 3236 SK-MEL-28 2651877 2512016 NS NS NS NS malignant_melanoma NS NS NS n COSV51778029 COSM6268 99381060 c.2257C>T p.P753S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 24336498 cell-line NS ENSP00000275493.2:p.Pro753Ser ENST00000275493.6:c.2257C>T 7:g.55174794C>T EGFR ENST00000275493.6 3633 3236 1819334 1819334 1718412 skin NS NS NS carcinoma squamous_cell_carcinoma_BRAF_inhibitor_related NS NS n COSM34166 178380439 c.? p.R108K Substitution - Missense + - Reported in another cancer sample as somatic 22726224 surgery - NOS NS ENSP00000275493.2:p.Arg108Lys EGFR ENST00000275493.6 3633 3236 1881892 1881892 1772043 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 45 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1909764 1909764 1798281 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23559152 surgery-fixed NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2136668 2136668 2006219 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246485 1246485 1158164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734164 1734164 1640113 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22843912 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046015 2046015 1926310 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2078481 2078481 1957200 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-WS009-T3 2869941 2724938 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105111008 COSM9808725 132612121 c.3098C>T p.T1033I Substitution - Missense 38 7:55202587-55202587 + - NEUTRAL .10728 Variant of unknown origin 26950094 surgery - NOS NS ENSP00000395243.3:p.Thr1033Ile ENST00000454757.6:c.3098C>T 7:g.55202587C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 911626 911626 829109 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862786 2862786 2717949 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862786 2862786 2717949 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 2476906 2476906 2339675 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 1083325 1083325 998490 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 17596643 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1451208 1451208 1375351 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1881378 1881378 1771529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914808 914808 832257 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631944 1631944 1548814 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302293 1302293 1213344 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009141 2009141 1891875 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895081 1895081 1783773 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770114 1770114 1674354 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22947115 surgery - NOS primary 68 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 B00426 2910515 2764377 ovary NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51792433 COSM6966446 133237386 c.1627G>A p.G543S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Reported in another cancer sample as somatic 33947352 surgery-fixed NS ENSP00000415559.1:p.Gly543Ser ENST00000455089.5:c.1627G>A 7:g.55165319G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231322 1231322 1143112 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1007072 1007072 924280 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51772347 COSM17570 132552045 c.2087C>T p.P696L Substitution - Missense 38 7:55174759-55174759 + - PATHOGENIC .9905 Reported in another cancer sample as somatic 16410744 NS primary ENSP00000395243.3:p.Pro696Leu ENST00000454757.6:c.2087C>T 7:g.55174759C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875803 1875803 1766386 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096000 2096000 1974064 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515237 1515237 1437847 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421222 2421222 2284144 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591051 1591051 1512167 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1024758 1024758 941735 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 surgery fresh/frozen metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980065 1980065 1866308 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 75 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450933 1450933 1375076 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 56 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891214 1891214 1780583 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089602 1089602 1004549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1000055 1000055 917278 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895096 1895096 1783788 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453432 1453432 1377465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631940 1631940 1548810 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162201 1162201 1074533 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879534 1879534 1770036 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 ESO-913 1890973 1780342 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV51780707 COSM1251019 132568401 c.3323G>T p.S1108I Substitution - Missense 38 7:55205442-55205442 + - NEUTRAL .36171 Reported in another cancer sample as somatic 23525077 surgery fresh/frozen primary 64 ENSP00000395243.3:p.Ser1108Ile ENST00000454757.6:c.3323G>T 7:g.55205442G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625557 2625557 2485969 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-16-W43116 2905463 2759719 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51861444 COSM13007 132548215 c.2200_2201delinsTT p.G734F Substitution - Missense 38 7:55181344-55181345 + - Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000395243.3:p.Gly734Phe ENST00000454757.6:c.2200_2201delinsTT 7:g.55181344_55181345delinsTT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0002PT00040T00040 2857344 2712644 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1530992 1530992 1453364 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631955 1631955 1548825 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891176 1891176 1780545 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226883 2226883 2094618 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1067061 1067061 983041 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1575156 1575156 1496597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1668524 1668524 1581817 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1231309 1231309 1143099 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899342 899342 816954 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1103754 1103754 1018006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 65 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1549834 1549834 1471939 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2057512 2057512 1937719 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24255770 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862718 2862718 2717881 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897840 897840 815462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875382 1875382 1765965 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983829 1983829 1870065 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983699 1983699 1869935 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895134 1895134 1783826 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1981032 1981032 1867268 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983742 1983742 1869978 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1844335 1844335 1737369 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729985 1729985 1635956 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860417 1860417 1751358 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077342 1077342 992596 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-209-tumor 2819091 2675390 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2549118 2549118 2410573 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425712 2425712 2288633 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887438 1887438 1777110 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1637252 1637252 1553300 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777217 1777217 1681220 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676409 1676409 1589177 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637211 1637211 1553259 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2227123 2227123 2094858 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 25120654 surgery - NOS recurrent 77 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2227123 2227123 2094858 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25120654 surgery - NOS recurrent 77 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899349 899349 816961 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891307 1891307 1780676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1197364 1197364 1109259 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2047768 2047768 1928040 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637701 2637701 2498074 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 DM2 2466860 2329691 skin face NS NS malignant_melanoma desmoplastic NS NS n COSV51781503 COSM5608352 99400773 c.1909C>T p.P637S Substitution - Missense 38 7:55171203-55171203 + - NEUTRAL .1586 Reported in another cancer sample as somatic 26343386 surgery-fixed NS 86 ENSP00000275493.2:p.Pro637Ser ENST00000275493.6:c.1909C>T 7:g.55171203C>T EGFR ENST00000275493.6 3633 3236 2819304 2819304 2675603 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 30711944 surgery - NOS recurrent 60 ENSP00000275493.2:p.Glu709Lys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1766864 1766864 1671184 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51836814 COSM329081 132581141 c.2066A>G p.E689G Substitution - Missense hom 38 7:55174738-55174738 + - PATHOGENIC .9986 Variant of unknown origin 22422135 surgery - NOS NS ENSP00000395243.3:p.Glu689Gly ENST00000454757.6:c.2066A>G 7:g.55174738A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-38-4629-01 1780093 1684092 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51776247 COSM6110417 132563707 c.1258G>A p.G420R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 68 ENSP00000395243.3:p.Gly420Arg ENST00000454757.6:c.1258G>A 7:g.55160233G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-194-tumor 2819079 2675378 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302273 1302273 1213324 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 DM2 2466860 2329691 skin face NS NS malignant_melanoma desmoplastic NS NS n COSV51800313 COSM5608354 99376626 c.2272G>A p.E758K Substitution - Missense 38 7:55174809-55174809 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 26343386 surgery-fixed NS 86 ENSP00000275493.2:p.Glu758Lys ENST00000275493.6:c.2272G>A 7:g.55174809G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372585 2372585 2235378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005461 1005461 922673 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51779191 COSM20897 132608150 c.1948A>G p.S650G Substitution - Missense 38 7:55173942-55173942 + - PATHOGENIC .98113 Variant of unknown origin 16822827 fixed - NOS NS 56 ENSP00000395243.3:p.Ser650Gly ENST00000454757.6:c.1948A>G 7:g.55173942A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592881 1592881 1513807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 1036631 1036631 953388 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM22420 178383004 c.? p.V843I Substitution - Missense + - Reported in another cancer sample as somatic 17201173 NS NS ENSP00000275493.2:p.Val843Ile EGFR ENST00000275493.6 3633 3236 1879238 1879238 1769793 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 23468066 fine needle aspirate NS 81 ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-270-tumor 2819119 2675418 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1601929 1601929 1521417 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22108465 fine needle aspirate metastasis 64 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525728 2525728 2387916 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 NPC0001PT00305T00305 2857328 2712628 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00278T00278 2857364 2712664 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 MG-197-tumor 2819082 2675381 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983754 1983754 1869990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 20 1433985 1343400 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862710 2862710 2717873 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067062 1067062 983042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077346 1077346 992600 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089142 1089142 1004096 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226864 2226864 2094599 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302283 1302283 1213334 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895115 1895115 1783807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-67-3770-01 1780199 1684198 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899344 899344 816956 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1108049 1108049 1021952 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17973572 surgery - NOS primary 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1839253 1839253 1733354 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51779524 COSM18425 132552477 c.2021G>A p.G674D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Reported in another cancer sample as somatic 23244191 surgery-fixed primary ENSP00000395243.3:p.Gly674Asp ENST00000454757.6:c.2021G>A 7:g.55174015G>A EGFR ENST00000275493.6 3633 3236 1136873 1136873 1049437 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1844340 1844340 1737374 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1892638 1892638 1781890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23566546 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1154314 1154314 1066650 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18957054 surgery-fixed NS 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279086 1279086 1190382 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed primary 50 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096171 2096171 1974235 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637086 1637086 1553134 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1197365 1197365 1109260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895126 1895126 1783818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631945 1631945 1548815 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895068 1895068 1783760 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891268 1891268 1780637 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372597 2372597 2235390 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891285 1891285 1780654 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1047002 1047002 963233 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924329 924329 841104 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-08-0390-01 1910243 1798534 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51822289 COSM42977 132570284 c.315G>T p.Q105H Substitution - Missense het 38 7:55143379-55143379 + - PATHOGENIC .90579 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 69 ENSP00000395243.3:p.Gln105His ENST00000454757.6:c.315G>T 7:g.55143379G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-08-0390-01 1910243 1798534 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 69 ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2476319 2476319 2339087 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 26870223 surgery-fixed metastasis 48 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2476319 2476319 2339087 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 26870223 surgery-fixed metastasis 48 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1992090 1992090 1877407 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 63 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1576797 1576797 1498238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 66 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479924 1479924 1403584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1945217 1945217 1832127 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51782636 COSM85961 132548929 c.2383G>A p.A795T Substitution - Missense 38 7:55191767-55191767 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 23295441 surgery-fixed NS ENSP00000395243.3:p.Ala795Thr ENST00000454757.6:c.2383G>A 7:g.55191767G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103809 1103809 1018061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593008 1593008 1513934 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592983 1592983 1513909 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773049 COSM22943 132549396 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Pro803Leu ENST00000454757.6:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2161698 2161698 2030305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24813888 surgery - NOS recurrent 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1881372 1881372 1771523 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1664613 1664613 1578063 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21899495 pleural effusion NS 64 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2148634 2148634 2017764 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469793 1469793 1393532 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525664 2525664 2387856 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469784 1469784 1393523 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081913 2081913 1960335 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1325685 1325685 1236181 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 20215545 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618796 1618796 1537548 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 68 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469864 1469864 1393603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2906659 2906659 2760910 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29616327 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2791158 2791158 2648356 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense hom 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 30922580 pleural effusion metastasis 60 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862731 2862731 2717894 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1992089 1992089 1877406 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 64 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2579623 2579623 2440960 NS NS NS NS malignant_melanoma NS NS NS n COSV51776282 COSM1168015 132547141 c.2123C>T p.P708L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000395243.3:p.Pro708Leu ENST00000454757.6:c.2123C>T 7:g.55174795C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-RT-S01711 1765173 1669493 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 63 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2422833 2422833 2285755 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422833 2422833 2285755 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1585373 1585373 1506694 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22011666 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618745 1618745 1537497 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 61 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1638773 1638773 1554772 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731388 1731388 1637354 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22457323 NS NS 71 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897844 897844 815466 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302279 1302279 1213330 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1573764 1573764 1495233 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21982684 surgery fresh/frozen primary 44 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1201855 1201855 1113741 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19369630 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110456 1110456 1024334 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1882222 1882222 1772373 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23392229 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2026150 2026150 1908239 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1964343 1964343 1850878 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2089572 2089572 1967781 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24511003 surgery fresh/frozen NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1505-ca 2823141 2678995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28818608 surgery-fixed NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493349 1493349 1416339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921909 1921909 1809227 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105831 2105831 1983869 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264271 2264271 2131255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 19 1596829 1517542 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20093389 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2007939 2007939 1890674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23907151 fine needle aspirate primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345599 2345599 2210271 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637110 1637110 1553158 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025393 2025393 1907482 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1351229 1351229 1261467 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20107421 surgery - NOS NS 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346547 2346547 2211210 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148634 2148634 2017764 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1112951 1112951 1026462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448997 surgery-fixed NS 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345552 2345552 2210224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345412 2345412 2210084 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2819304 2819304 2675603 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 30711944 surgery - NOS recurrent 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421228 2421228 2284150 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444724 1444724 1368967 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179666 1179666 1091628 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838668 1838668 1732769 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1097641 1097641 1012302 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345848 2345848 2210520 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444797 1444797 1369040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475402 1475402 1399101 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469427 1469427 1393166 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1512598 1512598 1435282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21508367 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000071 2000071 1884969 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046008 2046008 1926303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937506 1937506 1824440 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842961 1842961 1736209 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1732973 1732973 1638922 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22833420 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226151 2226151 2093886 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1856654 1856654 1749206 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23334261 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618796 1618796 1537548 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937589 1937589 1824523 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444725 1444725 1368968 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770582 1770582 1674822 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777355 1777355 1681358 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921937 1921937 1809255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965854 1965854 1852347 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637108 1637108 1553156 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2867548 2867548 2722582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 32441866 surgery - NOS NS 85 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096214 2096214 1974278 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230474 1230474 1142288 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966332 1966332 1852825 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1097651 1097651 1012312 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493332 1493332 1416322 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026245 2026245 1908334 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965898 1965898 1852391 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637263 1637263 1553311 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0002PT00015T00015 2857336 2712636 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625555 2625555 2485967 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625555 2625555 2485967 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1774681 1774681 1678905 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS metastasis 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705495 1705495 1613401 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105803 2105803 1983841 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148597 2148597 2017727 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885177 1885177 1775064 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535030 1535030 1457365 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1086840 1086840 1001860 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17848912 blood-bone marrow NS 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008966 2008966 1891700 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23979198 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469864 1469864 1393603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667714 1667714 1581007 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2156991 2156991 2025966 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476859 2476859 2339628 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430038 1430038 1339456 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106538 2106538 1984401 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637065 1637065 1553113 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264274 2264274 2131258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770514 1770514 1674754 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174307 1174307 1086326 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237692 1237692 1149439 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422941 2422941 2285863 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2033583 2033583 1915032 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24137397 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 924346 924346 841121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2076210 2076210 1955022 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51767182 COSM27110 99381953 c.2356G>A p.V786M Substitution - Missense het 38 7:55181365-55181365 + - PATHOGENIC .97319 Reported in another cancer sample as somatic 24406864 surgery-fixed primary 87 ENSP00000275493.2:p.Val786Met ENST00000275493.6:c.2356G>A 7:g.55181365G>A EGFR ENST00000275493.6 3633 3236 CT13 1063196 979241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 57 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 897800 897800 815422 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009144 2009144 1891878 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 RERF-LC-A1 946074 862600 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592881 1592881 1513807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1168026 1168026 1080268 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1168026 1168026 1080268 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1991361 1991361 1876696 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis 59 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162652 1162652 1074984 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19010870 surgery - NOS metastasis 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 4515 915986 833385 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51849884 COSM13192 133211467 c.2293G>A p.G765S Substitution - Missense 38 7:55181437-55181437 + - PATHOGENIC .98229 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000415559.1:p.Gly765Ser ENST00000455089.5:c.2293G>A 7:g.55181437G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891222 1891222 1780591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1792582 1792582 1694333 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51779524 COSM18425 132552477 c.2021G>A p.G674D Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .97987 Reported in another cancer sample as somatic 23070249 NS NS 58 ENSP00000395243.3:p.Gly674Asp ENST00000454757.6:c.2021G>A 7:g.55174015G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SNU-175 2302007 2167290 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51780766 COSM219795 132546924 c.2456C>T p.A819V Substitution - Missense het 38 7:55191840-55191840 + - PATHOGENIC .93098 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000395243.3:p.Ala819Val ENST00000454757.6:c.2456C>T 7:g.55191840C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860422 1860422 1751363 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345416 2345416 2210088 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705479 1705479 1613385 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430045 1430045 1339463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1576787 1576787 1498228 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 65 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043871 1043871 960212 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879548 1879548 1770050 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1522942 1522942 1445314 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 56 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S001097 1027690 944666 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 132550339 c.731C>A p.A244D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Ala244Asp ENST00000454757.6:c.731C>A 7:g.55154129C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631951 1631951 1548821 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983698 1983698 1869934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1738890 1738890 1644721 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1515253 1515253 1437863 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2562090 2562090 2423486 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264110 2264110 2131094 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 NPC0002PT00038T00038 2857332 2712632 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2626141 2626141 2486553 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51817684 COSM6191493 132596375 c.2441C>T p.A814V Substitution - Missense 38 7:55191825-55191825 + - PATHOGENIC .97885 Variant of unknown origin 26645239 surgery-fixed NS ENSP00000395243.3:p.Ala814Val ENST00000454757.6:c.2441C>T 7:g.55191825C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1882511 1882511 1772647 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767827 COSM1235378 133226447 c.2425A>T p.T809S Substitution - Missense hom 38 7:55191809-55191809 + - PATHOGENIC .98595 Reported in another cancer sample as somatic 23486275 NS NS 54 ENSP00000415559.1:p.Thr809Ser ENST00000455089.5:c.2425A>T 7:g.55191809A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1054399 1054399 970470 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239170 2239170 2106702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 59 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239170 2239170 2106702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 59 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895158 1895158 1783850 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-18-T40375 2905680 2759936 NS NS NS NS malignant_melanoma NS NS NS n COSV105864578 COSM9994221 132604608 c.3196C>T p.H1066Y Substitution - Missense 38 7:55205315-55205315 + - PATHOGENIC .90556 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000395243.3:p.His1066Tyr ENST00000454757.6:c.3196C>T 7:g.55205315C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891303 1891303 1780672 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2064721 2064721 1944798 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1547795 1547795 1469917 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed metastasis 76 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659795 2659795 2519953 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773049 COSM22943 133204348 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Pro803Leu ENST00000455089.5:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1530710 1530710 1453082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 21227397 surgery-fixed NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 57 2760165 2618698 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51780766 COSM219795 99373292 c.2591C>T p.A864V Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .93098 Reported in another cancer sample as somatic 29876005 surgery-fixed NS ENSP00000275493.2:p.Ala864Val ENST00000275493.6:c.2591C>T 7:g.55191840C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1575147 1575147 1496588 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860429 1860429 1751370 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1881381 1881381 1771532 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891314 1891314 1780683 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2026151 2026151 1908240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772347 COSM17570 132552045 c.2087C>T p.P696L Substitution - Missense het 38 7:55174759-55174759 + - PATHOGENIC .9905 Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000395243.3:p.Pro696Leu ENST00000454757.6:c.2087C>T 7:g.55174759C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-18-T40375 2905680 2759936 NS NS NS NS malignant_melanoma NS NS NS n COSV105864576 COSM9994315 132604569 c.1400C>T p.P467L Substitution - Missense 38 7:55161535-55161535 + - NEUTRAL .20165 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Pro467Leu ENST00000454757.6:c.1400C>T 7:g.55161535C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 RERF-LC-A1 946074 862600 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2057658 2057658 1937865 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24255770 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453416 1453416 1377449 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302290 1302290 1213341 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983710 1983710 1869946 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895069 1895069 1783761 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098867 1098867 1013459 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895118 1895118 1783810 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895095 1895095 1783787 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862723 2862723 2717886 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2840306 2840306 2695866 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1575148 1575148 1496589 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777277 1777277 1681280 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1668461 1668461 1581754 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2000199 2000199 1885097 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430042 1430042 1339460 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1602809 1602809 1522145 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264378 2264378 2131362 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453426 1453426 1377459 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594595 1594595 1515563 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983764 1983764 1870000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631947 1631947 1548817 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KT-2 1047093 963324 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17332333 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860415 1860415 1751356 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659799 2659799 2519957 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2676600 2676600 2535874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766331 COSM12366 99418284 c.2572C>A p.L858M Substitution - Missense 38 7:55191821-55191821 + - PATHOGENIC .93782 Reported in another cancer sample as somatic 28939152 NS NS 35 ENSP00000275493.2:p.Leu858Met ENST00000275493.6:c.2572C>A 7:g.55191821C>A EGFR ENST00000275493.6 3633 3236 2345069 2345069 2209741 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2046607 2046607 1926901 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24195468 surgery - NOS metastasis 70 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2163061 2163061 2031645 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345058 2345058 2209730 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2096221 2096221 1974285 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1054394 1054394 970465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983694 1983694 1869930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631953 1631953 1548823 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924333 924333 841108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891191 1891191 1780560 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1456557 1456557 1380532 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891315 1891315 1780684 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51779524 COSM18425 132552477 c.2021G>A p.G674D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Gly674Asp ENST00000454757.6:c.2021G>A 7:g.55174015G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990897 1990897 1876232 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891252 1891252 1780621 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914811 914811 832260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-16-X27754 2905540 2759796 gastrointestinal_tract_(site_indeterminate) NS NS NS carcinoma NS NS NS n COSV51789261 COSM12986 132561937 c.2294G>A p.G765D Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98244 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000395243.3:p.Gly765Asp ENST00000454757.6:c.2294G>A 7:g.55181438G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2696526 2696526 2555430 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 28201779 surgery fresh/frozen NS 72 ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-86-8055-01 1914088 1802370 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 79 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LU0858 1775134 1679358 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22948846 xenograft NS 35 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064708 2064708 1944785 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NCI-H3255 914952 832399 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15492241 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1625794 1625794 1543018 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453494 1453494 1377527 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2239167 2239167 2106699 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 35 ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 1547766 1547766 1469888 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 fine needle aspirate recurrent 57 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1547766 1547766 1469888 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 fine needle aspirate recurrent 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2582953 2582953 2444207 lung right_lower_lobe NS NS carcinoma adenocarcinoma transformed_to_squamous_cell_carcinoma NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 28024692 surgery - NOS recurrent 43 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2582953 2582953 2444207 lung right_lower_lobe NS NS carcinoma adenocarcinoma transformed_to_squamous_cell_carcinoma NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28024692 surgery - NOS recurrent 43 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278184 1278184 1189482 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879556 1879556 1770058 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2476836 2476836 2339605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1965848 1965848 1852341 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345846 2345846 2210518 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1694974 1694974 1603194 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 47 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895138 1895138 1783830 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592990 1592990 1513916 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983708 1983708 1869944 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DCR7 1690657 1598934 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 133216830 c.1341C>A p.S447R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000415559.1:p.Ser447Arg ENST00000455089.5:c.1341C>A 7:g.55160316C>A EGFR ENST00000275493.6 3633 3236 1618061 1618061 1536857 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2595738 2595738 2456614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS 69 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2595738 2595738 2456614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS 69 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1596619 1596619 1517401 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22071596 blood-bone marrow NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2290963 2290963 2157028 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1 1077300 992554 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675155 2675155 2534429 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766268 COSM13183 133205606 c.2090T>C p.V697A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Reported in another cancer sample as somatic 29075127 surgery fresh/frozen NS ENSP00000415559.1:p.Val697Ala ENST00000455089.5:c.2090T>C 7:g.55174762T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043134 1043134 959475 upper_aerodigestive_tract tonsil NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51793896 COSM22954 133217512 c.2189G>A p.C730Y Substitution - Missense 38 7:55181333-55181333 + - PATHOGENIC .97278 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 53 ENSP00000415559.1:p.Cys730Tyr ENST00000455089.5:c.2189G>A 7:g.55181333G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1894922 1894922 1783614 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879498 1879498 1770000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2113076 2113076 1987337 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 24595526 surgery-fixed NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226876 2226876 2094611 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875361 1875361 1765944 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1668466 1668466 1581759 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51795632 COSM26509 99395627 c.2227G>A p.A743T Substitution - Missense 38 7:55174764-55174764 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Ala743Thr ENST00000275493.6:c.2227G>A 7:g.55174764G>A EGFR ENST00000275493.6 3633 3236 1885178 1885178 1775065 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770672 1770672 1674912 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1074943 1074943 990197 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1310472 1310472 1221417 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895129 1895129 1783821 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899320 899320 816932 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429263 1429263 1338714 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1512597 1512597 1435281 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21508367 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983707 1983707 1869943 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226915 2226915 2094650 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-70-6722-01 1783058 1687057 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 418 fresh/frozen - NOS primary 47 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077370 1077370 992624 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891305 1891305 1780674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899339 899339 816951 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1530703 1530703 1453075 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21227397 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983740 1983740 1869976 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899350 899350 816962 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1434023 1434023 1343438 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891279 1891279 1780648 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042903 1042903 959244 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 946825 946825 863348 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2659805 2659805 2519963 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1451207 1451207 1375350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602810 1602810 1522146 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429293 1429293 1338744 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077327 1077327 992581 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891169 1891169 1780538 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1635904 1635904 1552008 lung NS NS NS carcinoma undifferentiated_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22102479 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2659810 2659810 2519968 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2095974 2095974 1974038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076202 2076202 1955015 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 24389444 surgery-fixed NS 77 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2064718 2064718 1944795 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2372836 2372836 2235629 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25904052 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230460 1230460 1142274 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1707041 1707041 1614947 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM86998 178379356 c.? p.R776C Substitution - Missense + - Reported in another cancer sample as somatic 22695392 surgery-fixed NS ENSP00000275493.2:p.Arg776Cys EGFR ENST00000275493.6 3633 3236 1879572 1879572 1770074 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1964313 1964313 1850848 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1043131 1043131 959472 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51789261 COSM12986 99390495 c.2429G>A p.G810D Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98244 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 49 ENSP00000275493.2:p.Gly810Asp ENST00000275493.6:c.2429G>A 7:g.55181438G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602795 1602795 1522131 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1074945 1074945 990199 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 44 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 11-18-ER2-1 1731374 1637340 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22815900 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983832 1983832 1870068 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1074999 1074999 990253 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 55 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 KT-4 1047094 963325 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17332333 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 V180 1179747 1091709 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1202563 1202563 1114449 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1231314 1231314 1143104 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924338 924338 841113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1077343 1077343 992597 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1981022 1981022 1867258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1429279 1429279 1338730 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875794 1875794 1766377 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899306 899306 816918 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875383 1875383 1765966 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2471440 2471440 2334227 skin NS NS NS malignant_melanoma NS NS NS n COSV51836136 COSM5574310 132566153 c.2764G>A p.E922K Substitution - Missense 38 7:55200366-55200366 + - PATHOGENIC .99379 Reported in another cancer sample as somatic 25452114 surgery fresh/frozen metastasis 55 ENSP00000395243.3:p.Glu922Lys ENST00000454757.6:c.2764G>A 7:g.55200366G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924291 924291 841066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-089-tumor 2819020 2675319 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895113 1895113 1783805 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879565 1879565 1770067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043852 1043852 960193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2141648 2141648 2010866 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24657128 surgery fresh/frozen NS 73 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1648526 1648526 1563481 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830809 COSM85993 132579933 c.2125A>G p.K709E Substitution - Missense 38 7:55174797-55174797 + - PATHOGENIC .99211 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000395243.3:p.Lys709Glu ENST00000454757.6:c.2125A>G 7:g.55174797A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1876990 1876990 1767552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2426841 2426841 2289762 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1585337 1585337 1506658 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22011666 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1590995 1590995 1512111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2476842 2476842 2339611 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2076200 2076200 1955013 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23986053 NS NS 83 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032219 2032219 1913690 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2617729 2617729 2478215 lung right NS NS carcinoma adenocarcinoma transformed_to_squamous_cell_carcinoma NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 26483048 surgery - NOS recurrent 64 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481220 1481220 1404849 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1547772 1547772 1469894 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 69 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1585325 1585325 1506646 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22011666 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1890243 1890243 1779665 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22773810 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422841 2422841 2285763 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2228277 2228277 2096006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2579341 2579341 2440678 NS NS NS NS malignant_melanoma NS NS NS n COSV51770777 COSM28286 133220429 c.2359C>T p.R787C Substitution - Missense 38 7:55191743-55191743 + - PATHOGENIC .95135 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000415559.1:p.Arg787Cys ENST00000455089.5:c.2359C>T 7:g.55191743C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479932 1479932 1403592 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110449 1110449 1024327 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042921 1042921 959262 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1075004 1075004 990258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 71 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594598 1594598 1515566 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1434020 1434020 1343435 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064724 2064724 1944801 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450942 1450942 1375085 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 65 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1075003 1075003 990257 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 55 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005358 1005358 922570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103803 1103803 1018055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226886 2226886 2094621 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875793 1875793 1766376 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1000053 1000053 917276 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2509062 2509062 2371397 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_II pleomorphic_xanthoastrocytoma NS n COSV51822879 COSM4680399 99382634 c.2039G>A p.R680Q Substitution - Missense 38 7:55173102-55173102 + - PATHOGENIC .99814 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 16 ENSP00000275493.2:p.Arg680Gln ENST00000275493.6:c.2039G>A 7:g.55173102G>A EGFR ENST00000275493.6 3633 3236 2625600 2625600 2486012 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 44 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2402521 2402521 2265377 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983766 1983766 1870002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891266 1891266 1780635 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895147 1895147 1783839 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-171-tumor 2819064 2675363 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897825 897825 815447 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2113068 2113068 1987329 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24595526 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2113068 2113068 1987329 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51767182 COSM27110 132554778 c.2221G>A p.V741M Substitution - Missense 38 7:55181365-55181365 + - PATHOGENIC .97319 Reported in another cancer sample as somatic 24595526 surgery-fixed NS ENSP00000395243.3:p.Val741Met ENST00000454757.6:c.2221G>A 7:g.55181365G>A EGFR ENST00000275493.6 3633 3236 1895116 1895116 1783808 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631949 1631949 1548819 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1740210 1740210 1645811 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22836650 surgery fresh/frozen NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1740210 1740210 1645811 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766331 COSM12366 132582479 c.2437C>A p.L813M Substitution - Missense het 38 7:55191821-55191821 + - PATHOGENIC .93782 Reported in another cancer sample as somatic 22836650 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Met ENST00000454757.6:c.2437C>A 7:g.55191821C>A EGFR ENST00000275493.6 3633 3236 TCGA-46-3769-01 1781825 1685824 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51799159 COSM747427 99402636 c.1766C>T p.P589L Substitution - Missense 38 7:55165323-55165323 + - PATHOGENIC .95834 Reported in another cancer sample as somatic 418 fresh/frozen - NOS primary 57 ENSP00000275493.2:p.Pro589Leu ENST00000275493.6:c.1766C>T 7:g.55165323C>T EGFR ENST00000275493.6 3633 3236 1535021 1535021 1457356 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240669 2240669 2108200 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 44 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240678 2240678 2108209 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 57 ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778531 2778531 2636585 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51775222 COSM13189 133214176 c.2216C>T p.S739F Substitution - Missense 38 7:55181360-55181360 + - PATHOGENIC .94833 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000415559.1:p.Ser739Phe ENST00000455089.5:c.2216C>T 7:g.55181360C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302244 1302244 1213295 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879229 1879229 1769784 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51792805 COSM13005 133203995 c.2183A>T p.H728L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 23468066 fine needle aspirate NS 39 ENSP00000415559.1:p.His728Leu ENST00000455089.5:c.2183A>T 7:g.55181327A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879497 1879497 1769999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1576789 1576789 1498230 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 71 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1506756 1506756 1429625 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 21422421 surgery - NOS metastasis 89 ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1506756 1506756 1429625 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51777782 COSM6227 132554599 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 21422421 surgery - NOS metastasis 89 ENSP00000395243.3:p.His790Leu ENST00000454757.6:c.2369A>T 7:g.55191753A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009142 2009142 1891876 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879553 1879553 1770055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879536 1879536 1770038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1523013 1523013 1445385 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 60 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2819295 2819295 2675594 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 30711944 pleural effusion recurrent 63 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879523 1879523 1770025 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD_E01166 1765174 1669494 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 22980975 surgery - NOS primary ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875799 1875799 1766382 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-67-6217-01 1780210 1684209 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LIM1215_R5_Cetux 2841371 2696923 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51776247 COSM6110417 132563707 c.1258G>A p.G420R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000395243.3:p.Gly420Arg ENST00000454757.6:c.1258G>A 7:g.55160233G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983692 1983692 1869928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2651872 2651872 2512012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27257132 surgery - NOS primary 71 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2344937 2344937 2209609 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25674250 NS NS 48 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106550 2106550 1984413 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141277 1141277 1053725 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096093 2096093 1974157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096209 2096209 1974273 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777414 1777414 1681417 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 18 2570181 2431478 skin face NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51774667 COSM53194 99382658 c.2197C>T p.P733S Substitution - Missense 38 7:55174734-55174734 + - PATHOGENIC .99806 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 53 ENSP00000275493.2:p.Pro733Ser ENST00000275493.6:c.2197C>T 7:g.55174734C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895075 1895075 1783767 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1475466 1475466 1399165 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1965275 1965275 1851770 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23803047 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777396 1777396 1681399 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891298 1891298 1780667 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592885 1592885 1513811 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765252 COSM13009 132568674 c.1991A>G p.E664G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Glu664Gly ENST00000454757.6:c.1991A>G 7:g.55173985A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009160 2009160 1891894 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1857889 1857889 1750379 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSM1169669 178386037 c.? p.T263P Substitution - Missense + - Reported in another cancer sample as somatic 23243055 surgery-fixed NS ENSP00000275493.2:p.Thr263Pro EGFR ENST00000275493.6 3633 3236 1885170 1885170 1775057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476861 2476861 2339630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000189 2000189 1885087 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046052 2046052 1926347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336414 1336414 1246799 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20430469 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2426841 2426841 2289762 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777326 1777326 1681329 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345499 2345499 2210171 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680762 2680762 2540035 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2238952 2238952 2106484 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25137181 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047736 2047736 1928008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed primary 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345449 2345449 2210121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2750884 2750884 2609580 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27086595 surgery-fixed NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1590995 1590995 1512111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346486 2346486 2211149 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345574 2345574 2210246 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345414 2345414 2210086 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1795765 1795765 1697513 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23110940 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551541 1551541 1473646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444781 1444781 1369024 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1812622 1812622 1711956 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23174717 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096179 2096179 1974243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279050 1279050 1190346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed primary 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444777 1444777 1369020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264181 2264181 2131165 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000195 2000195 1885093 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996575 1996575 1881784 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23922984 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2757126 2757126 2615769 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 133203995 c.2183A>T p.H728L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 29858019 circulating tumour recurrent 50 ENSP00000415559.1:p.His728Leu ENST00000455089.5:c.2183A>T 7:g.55181327A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2733534 2733534 2592287 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 29704676 surgery - NOS recurrent 36 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042913 1042913 959254 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1734170 1734170 1640119 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22843912 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1026383 1026383 943359 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17047648 surgery-fixed primary 83 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551538 1551538 1473643 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226181 2226181 2093916 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842907 1842907 1736166 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23261229 surgery-fixed NS 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542148 1542148 1464451 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008796 2008796 1891530 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1707028 1707028 1614934 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22695392 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1505434 1505434 1428303 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21422434 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264084 2264084 2131068 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960159 1960159 1846799 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346526 2346526 2211189 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983129 983129 898847 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2617729 2617729 2478215 lung right NS NS carcinoma adenocarcinoma transformed_to_squamous_cell_carcinoma NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26483048 surgery - NOS recurrent 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425713 2425713 2288634 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142100 2142100 2011318 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547772 1547772 1469894 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246636 1246636 1158315 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881914 1881914 1772065 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237701 1237701 1149448 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921899 1921899 1809217 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1097639 1097639 1012300 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1202163 1202163 1114049 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19371962 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205954 2205954 2074187 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729979 1729979 1635950 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2486039 2486039 2348688 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27013585 surgery - NOS primary 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547804 1547804 1469926 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591010 1591010 1512126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096173 2096173 1974237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2069204 2069204 1948779 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24346091 NS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469353 1469353 1393092 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264305 2264305 2131289 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345601 2345601 2210273 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214555 2214555 2082679 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142096 2142096 2011314 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 60 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593007 1593007 1513933 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891231 1891231 1780600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1876992 1876992 1767554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875801 1875801 1766384 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1881379 1881379 1771530 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103802 1103802 1018054 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18271876 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067072 1067072 983052 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875349 1875349 1765932 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1135352 1135352 1047918 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 17591931 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2867538 2867538 2722577 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 32441866 surgery - NOS NS 59 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2148646 2148646 2017776 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2862265 2862265 2717455 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25969368 surgery-fixed primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1707040 1707040 1614946 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 22695392 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625599 2625599 2486011 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 44 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226771 2226771 2094506 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51795632 COSM26509 132565559 c.2092G>A p.A698T Substitution - Missense 38 7:55174764-55174764 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Ala698Thr ENST00000454757.6:c.2092G>A 7:g.55174764G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1738936 1738936 1644767 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897801 897801 815423 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 TCGA-70-6722-01 1783058 1687057 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 418 fresh/frozen - NOS primary 47 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 11 2570179 2431476 skin face NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51775222 COSM13189 99385712 c.2351C>T p.S784F Substitution - Missense 38 7:55181360-55181360 + - PATHOGENIC .94833 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 65 ENSP00000275493.2:p.Ser784Phe ENST00000275493.6:c.2351C>T 7:g.55181360C>T EGFR ENST00000275493.6 3633 3236 1991359 1991359 1876694 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2659798 2659798 2519956 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1530989 1530989 1453361 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239173 2239173 2106705 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 70 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162180 1162180 1074512 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51785698 COSM28510 132588338 c.2027G>C p.G676A Substitution - Missense 38 7:55174021-55174021 + - PATHOGENIC .98515 Variant of unknown origin 19020901 NS NS ENSP00000395243.3:p.Gly676Ala ENST00000454757.6:c.2027G>C 7:g.55174021G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1188169 1188169 1100068 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51785879 COSM29274 132577669 c.2119T>C p.S707P Substitution - Missense het 38 7:55174791-55174791 + - PATHOGENIC .99066 Variant of unknown origin 19253367 surgery-fixed primary 66 ENSP00000395243.3:p.Ser707Pro ENST00000454757.6:c.2119T>C 7:g.55174791T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067042 1067042 983022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1960181 1960181 1846821 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1481260 1481260 1404889 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1136881 1136881 1049445 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 983158 983158 898876 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1154310 1154310 1066646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18957054 surgery-fixed NS 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278179 1278179 1189477 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237694 1237694 1149441 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891330 1891330 1780699 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2065006 2065006 1945083 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1246665 1246665 1158344 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205983 2205983 2074216 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096230 2096230 1974294 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2096233 2096233 1974297 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2264374 2264374 2131358 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1532702 1532702 1455062 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 20925915 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1531003 1531003 1453375 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2228304 2228304 2096020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345085 2345085 2209757 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2064731 2064731 1944808 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226889 2226889 2094624 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891335 1891335 1780704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891335 1891335 1780704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-189-tumor 2819075 2675374 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879237 1879237 1769792 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23468066 surgery-fixed NS 48 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043867 1043867 960208 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043872 1043872 960213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 132565801 c.2146G>T p.D716Y Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99554 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Asp716Tyr ENST00000454757.6:c.2146G>T 7:g.55174818G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043872 1043872 960213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862120 2862120 2717322 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862120 2862120 2717322 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1746668 1746668 1651644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 78 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2364046 2364046 2226960 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25567908 surgery-fixed NS 41 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1197335 1197335 1109230 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19179899 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592994 1592994 1513920 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CT13 1063196 979241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 57 ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778773 2778773 2636827 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2819302 2819302 2675601 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 30711944 pleural effusion recurrent 64 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-14-F34521 2905527 2759783 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51836288 COSM6348843 132575756 c.2207G>T p.C736F Substitution - Missense 38 7:55181351-55181351 + - PATHOGENIC .98402 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000395243.3:p.Cys736Phe ENST00000454757.6:c.2207G>T 7:g.55181351G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450848 1450848 1374991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 57 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879515 1879515 1770017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001553 1001553 918776 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15851406 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1567592 1567592 1489224 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21949883 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2869175 2869175 2724192 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSM9522567 178379362 c.? p.A871T Substitution - Missense + - Reported in another cancer sample as somatic 32524539 surgery-fixed primary ENSP00000275493.2:p.Ala871Thr EGFR ENST00000275493.6 3633 3236 18 1481512 1405141 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21240995 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469369 1469369 1393108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515236 1515236 1437846 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515260 1515260 1437870 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1029016 1029016 945887 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17075123 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2067303 2067303 1947100 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23783797 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729973 1729973 1635944 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421233 2421233 2284155 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1024768 1024768 941745 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1484342 1484342 1407968 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 132548474 c.2117C>T p.T706I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Reported in another cancer sample as somatic 21266046 surgery-fixed primary 64 ENSP00000395243.3:p.Thr706Ile ENST00000454757.6:c.2117C>T 7:g.55174789C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429264 1429264 1338715 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1310477 1310477 1221422 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1974003 1974003 1860245 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1974003 1974003 1860245 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895142 1895142 1783834 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899352 899352 816964 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593003 1593003 1513929 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1816945 1816945 1716113 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1777259 1777259 1681262 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1223897 1223897 1135729 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19517135 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240542 2240542 2108073 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25227801 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770625 1770625 1674865 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240548 2240548 2108079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25227801 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638761 1638761 1554760 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422841 2422841 2285763 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1107787 1107787 1021690 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770546 1770546 1674786 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1196949 1196949 1108844 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2693341 2693341 2552260 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28062544 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228277 2228277 2096006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1453417 1453417 1377450 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1515248 1515248 1437858 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468067 1468067 1391913 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 48 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618792 1618792 1537544 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22215752 surgery-fixed NS 44 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1295349 1295349 1206428 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777782 COSM6227 133210005 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 19884551 surgery fresh/frozen NS ENSP00000415559.1:p.His790Leu ENST00000455089.5:c.2369A>T 7:g.55191753A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924345 924345 841120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875375 1875375 1765958 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042919 1042919 959260 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-0616-01 1910246 1798537 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 36 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891284 1891284 1780653 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1576794 1576794 1498235 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 86 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226856 2226856 2094591 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1235144 1235144 1146930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 76 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2644798 2644798 2505085 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 28625641 surgery - NOS recurrent 69 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1054394 1054394 970465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2840306 2840306 2695866 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592881 1592881 1513807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767280 COSM133183 132563720 c.2007G>C p.K669N Substitution - Missense 38 7:55174001-55174001 + - PATHOGENIC .89357 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Lys669Asn ENST00000454757.6:c.2007G>C 7:g.55174001G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1648540 1648540 1563495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 132549396 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000395243.3:p.Pro803Leu ENST00000454757.6:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1648540 1648540 1563495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1914902 1914902 1802904 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096220 2096220 1974284 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2096220 2096220 1974284 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618792 1618792 1537544 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 44 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226187 2226187 2093922 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2595737 2595737 2456613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS 62 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2595737 2595737 2456613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS 62 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1637245 1637245 1553293 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1573771 1573771 1495240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21982684 surgery fresh/frozen metastasis 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983731 1983731 1869967 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891207 1891207 1780576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098860 1098860 1013452 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226884 2226884 2094619 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1046994 1046994 963225 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891332 1891332 1780701 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891287 1891287 1780656 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372588 2372588 2235381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983717 1983717 1869953 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983768 1983768 1870004 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891212 1891212 1780581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875372 1875372 1765955 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372593 2372593 2235386 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098872 1098872 1013464 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429327 1429327 1338778 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899307 899307 816919 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1931639 1931639 1818929 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895085 1895085 1783777 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897809 897809 815431 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895154 1895154 1783846 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 946821 946821 863344 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862075 2862075 2717281 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 32122695 circulating tumour NS 62 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862075 2862075 2717281 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 32122695 circulating tumour NS 62 ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1047007 1047007 963238 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2680718 2680718 2539991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27998968 surgery-fixed NS 37 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1196946 1196946 1108841 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879229 1879229 1769784 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51792805 COSM13005 99375713 c.2318A>T p.H773L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 23468066 fine needle aspirate NS 39 ENSP00000275493.2:p.His773Leu ENST00000275493.6:c.2318A>T 7:g.55181327A>T EGFR ENST00000275493.6 3633 3236 1835507 1835507 1730539 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 23242440 NS NS 74 ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042854 1042854 959195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879238 1879238 1769793 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23468066 fine needle aspirate NS 81 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862074 2862074 2717281 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 32122695 surgery - NOS NS 62 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2509057 2509057 2371392 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51783296 COSM5878511 132590253 c.526G>T p.G176W Substitution - Missense 38 7:55152578-55152578 + - NEUTRAL .4823 Variant of unknown origin 26919320 surgery - NOS NS 43 ENSP00000395243.3:p.Gly176Trp ENST00000454757.6:c.526G>T 7:g.55152578G>T EGFR ENST00000275493.6 3633 3236 1585316 1585316 1506637 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22011666 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618970 1618970 1537692 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22019513 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450926 1450926 1375069 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 51 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895094 1895094 1783786 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1664607 1664607 1578057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21899495 pleural effusion NS 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1627724 1627724 1544636 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1320607 1320607 1231494 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20159991 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-083-tumor 2819016 2675315 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00240T00240 2857369 2712669 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-168-tumor 2819062 2675361 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659764 2659764 2519922 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51799041 COSM52931 133235462 c.2060T>C p.I687T Substitution - Missense 38 7:55174732-55174732 + - PATHOGENIC .98814 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Ile687Thr ENST00000455089.5:c.2060T>C 7:g.55174732T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2147907 2147907 2017050 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51793006 COSM3727812 132565404 c.2101_2106delinsAATTAT p.E701_L702delinsNY Substitution - Missense 38 7:55174773-55174778 + - Variant of unknown origin 24722155 surgery-fixed metastasis 68 ENSP00000395243.3:p.Glu701_Leu702delinsAsnTyr ENST00000454757.6:c.2101_2106delinsAATTAT 7:g.55174773_55174778delinsAATTAT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862712 2862712 2717875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862712 2862712 2717875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 109610 2812911 2669325 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 16 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1676435 1676435 1589203 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444737 1444737 1368980 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014258 1014258 931432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421172 2421172 2284094 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450937 1450937 1375080 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 61 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593016 1593016 1513942 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450931 1450931 1375074 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110464 1110464 1024342 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899308 899308 816920 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593012 1593012 1513938 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1500176 1500176 1423055 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1672450 1672450 1585504 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21729655 surgery-fixed primary 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239168 2239168 2106700 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 132551401 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 39 ENSP00000395243.3:p.Arg731His ENST00000454757.6:c.2192G>A 7:g.55181336G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2230121 2230121 2097831 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 132550443 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 24811487 surgery - NOS NS ENSP00000395243.3:p.Leu702Pro ENST00000454757.6:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895111 1895111 1783803 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042860 1042860 959201 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042860 1042860 959201 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51803429 COSM7002279 132557298 c.1145G>A p.R382H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000395243.3:p.Arg382His ENST00000454757.6:c.1145G>A 7:g.55157735G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631939 1631939 1548809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983819 1983819 1870055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1877000 1877000 1767562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875341 1875341 1765924 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895071 1895071 1783763 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1107245 1107245 1021157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1451639 1451639 1375782 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855820 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990896 1990896 1876231 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450860 1450860 1375003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2651873 2651873 2512013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27257132 surgery - NOS recurrent 71 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1694965 1694965 1603185 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 47 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1135427 1135427 1047991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983716 1983716 1869952 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875802 1875802 1766385 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2616328 2616328 2476814 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26118982 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625548 2625548 2485960 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1585317 1585317 1506638 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22011666 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 NCI-H1975 1047098 963329 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 17332333 cell-line NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618641 1618641 1537393 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 82 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1246730 1246730 1158409 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081902 2081902 1960324 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-066-tumor 2819004 2675303 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2860650 2860650 2715938 central_nervous_system choroid_plexus NS NS other choroid_plexus_papilloma NS NS n COSV51803731 COSM28604 133205257 c.2371C>T p.R791C Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .95213 Reported in another cancer sample as somatic 31612017 surgery-fixed NS 3 ENSP00000415559.1:p.Arg791Cys ENST00000455089.5:c.2371C>T 7:g.55191755C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891309 1891309 1780678 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2664359 2664359 2524422 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 57 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2664352 2664352 2524418 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 48 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1592996 1592996 1513922 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2009145 2009145 1891879 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897810 897810 815432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2095937 2095937 1974001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 BC1-1 2824183 2680011 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51787208 COSM327142 99376659 c.3352G>A p.A1118T Substitution - Missense 38 7:55205336-55205336 + - NEUTRAL .10522 Reported in another cancer sample as somatic 31867841 circulating tumour recurrent 54 ENSP00000275493.2:p.Ala1118Thr ENST00000275493.6:c.3352G>A 7:g.55205336G>A EGFR ENST00000275493.6 3633 3236 2421161 2421161 2284083 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-02-0021-01 1910130 1798421 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 133208833 c.619C>T p.R207C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 44 ENSP00000415559.1:p.Arg207Cys ENST00000455089.5:c.619C>T 7:g.55154017C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980073 1980073 1866316 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 69 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 18 2570181 2431478 skin face NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51774667 COSM53194 133211250 c.2062C>T p.P688S Substitution - Missense 38 7:55174734-55174734 + - PATHOGENIC .99806 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 53 ENSP00000415559.1:p.Pro688Ser ENST00000455089.5:c.2062C>T 7:g.55174734C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1790517 1790517 1693496 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766268 COSM13183 133205606 c.2090T>C p.V697A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Reported in another cancer sample as somatic 16152581 fixed - NOS NS ENSP00000415559.1:p.Val697Ala ENST00000455089.5:c.2090T>C 7:g.55174762T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009156 2009156 1891890 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098855 1098855 1013447 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2555789 2555789 2417226 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 26599269 surgery - NOS NS 65 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136866 1136866 1049430 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1043862 1043862 960203 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136863 1136863 1049427 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897819 897819 815441 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1162203 1162203 1074535 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302294 1302294 1213345 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 914812 914812 832261 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0001303-T03-IM5 2719408 2578229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1594125 1594125 1515050 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724887 surgery fresh/frozen NS 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1166440 1166440 1078754 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1043863 1043863 960204 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 98 897199 814822 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15329413 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1166441 1166441 1078755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 37 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891185 1891185 1780554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1005357 1005357 922569 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1996929 1996929 1882138 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM53179 178383575 c.? p.V834L Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 54 ENSP00000275493.2:p.Val834Leu EGFR ENST00000275493.6 3633 3236 2476906 2476906 2339675 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1107243 1107243 1021155 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2078475 2078475 1957194 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1213637 1213637 1125504 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18978556 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914890 1914890 1802892 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965919 1965919 1852412 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774698 1774698 1678922 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 pleural effusion recurrent 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734171 1734171 1640120 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22843912 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345396 2345396 2210068 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1076408 1076408 991662 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17607119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118438 2118438 1992673 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2406807 2406807 2269687 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637087 1637087 1553135 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770738 1770738 1674978 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214561 2214561 2082685 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474348 2474348 2337117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878786 2878786 2733301 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22006985 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1319152 1319152 1230051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20146086 cerebrospinal fluid metastasis 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096026 2096026 1974090 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046625 2046625 1926919 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875695 1875695 1766278 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046060 2046060 1926355 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2245046 2245046 2112322 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705464 1705464 1613370 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637099 1637099 1553147 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468886 1468886 1392625 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21128242 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844339 1844339 1737373 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887401 1887401 1777073 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096035 2096035 1974099 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083805 1083805 998970 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774692 1774692 1678916 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS recurrent 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2241825 2241825 2109356 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25228365 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246663 1246663 1158342 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986154 1986154 1872390 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878851 2878851 2733366 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27368130 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246720 1246720 1158399 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964324 1964324 1850859 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551544 1551544 1473649 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046063 2046063 1926358 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542344 1542344 1464647 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770613 1770613 1674853 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444787 1444787 1369030 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476881 2476881 2339650 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000200 2000200 1885098 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479088 1479088 1402781 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2855929 2855929 2711331 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24482415 surgery - NOS NS 80 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1047974 1047974 964202 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17337084 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264095 2264095 2131079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203106 2203106 2071364 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278180 1278180 1189478 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637154 1637154 1553202 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194730 1194730 1106625 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042917 1042917 959258 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659759 2659759 2519917 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659759 2659759 2519917 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860425 1860425 1751366 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089140 1089140 1004094 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777269 1777269 1681272 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777399 1777399 1681402 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246651 1246651 1158330 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2132033 2132033 2006096 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24429877 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345527 2345527 2210199 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278188 1278188 1189486 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095885 2095885 1973949 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549140 2549140 2410595 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081902 2081902 1960324 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264284 2264284 2131268 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734163 1734163 1640112 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22843912 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549119 2549119 2410574 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777246 1777246 1681249 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469498 1469498 1393237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345413 2345413 2210085 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637155 1637155 1553203 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278182 1278182 1189480 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770580 1770580 1674820 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914951 1914951 1802953 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680743 2680743 2540016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 46 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1706970 1706970 1614876 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22722787 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475390 1475390 1399089 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777408 1777408 1681411 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885172 1885172 1775059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203078 2203078 2071336 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444721 1444721 1368964 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148593 2148593 2017723 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983134 983134 898852 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429325 1429325 1338776 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1994212 1994212 1879467 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 132549396 c.2408C>T p.P803L Substitution - Missense het 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 23897956 surgery - NOS primary 56 ENSP00000395243.3:p.Pro803Leu ENST00000454757.6:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 H3255 2776279 2634415 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29681454 NS NS 47 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891327 1891327 1780696 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067078 1067078 983058 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659796 2659796 2519954 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773049 COSM22943 132549396 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Pro803Leu ENST00000454757.6:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879232 1879232 1769787 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51767379 COSM85894 132557468 c.2392G>A p.V798I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 23468066 surgery-fixed NS 74 ENSP00000395243.3:p.Val798Ile ENST00000454757.6:c.2392G>A 7:g.55191776G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891253 1891253 1780622 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KTSq-1 946070 862596 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089605 1089605 1004552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2027350 2027350 1909418 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 30 ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2841966 2841966 2697515 soft_tissue fibrous_tissue_and_uncertain_origin abdomen NS desmoid_tumour-fibromatosis NS NS NS n COSV51773049 COSM22943 132549396 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 32099073 surgery-fixed NS 52 ENSP00000395243.3:p.Pro803Leu ENST00000454757.6:c.2408C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 LUAD-NYU696 1765167 1669487 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 57 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2425732 2425732 2288653 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1295792 1295792 1206864 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 19692934 cerebrospinal fluid metastasis 61 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2862711 2862711 2717874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765252 COSM13009 99400543 c.2126A>G p.E709G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Glu709Gly ENST00000275493.6:c.2126A>G 7:g.55173985A>G EGFR ENST00000275493.6 3633 3236 2862711 2862711 2717874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-246-tumor 2819109 2675408 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1881374 1881374 1771525 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862100 2862100 2717302 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51830861 COSM6219 99378340 c.2248G>C p.A750P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000275493.2:p.Ala750Pro ENST00000275493.6:c.2248G>C 7:g.55174785G>C EGFR ENST00000275493.6 3633 3236 2425786 2425786 2288707 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1481246 1481246 1404875 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1774697 1774697 1678921 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS primary 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1042905 1042905 959246 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1162989 1162989 1075312 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18992959 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637132 1637132 1553180 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237691 1237691 1149438 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924526 924526 841299 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2346475 2346475 2211138 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535026 1535026 1457361 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 8LFG8F 2762947 2621206 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51839851 COSM7340115 99404654 c.1118C>A p.P373Q Substitution - Missense 38 7:55156644-55156644 + - PATHOGENIC .76649 Reported in another cancer sample as somatic 29615459 NS metastasis 45 ENSP00000275493.2:p.Pro373Gln ENST00000275493.6:c.1118C>A 7:g.55156644C>A EGFR ENST00000275493.6 3633 3236 1325684 1325684 1236180 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 20215545 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1325684 1325684 1236180 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20215545 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444802 1444802 1369045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591024 1591024 1512140 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770651 1770651 1674891 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479096 1479096 1402789 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218520 2218520 2086531 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1592887 1592887 1513813 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1751716 1751716 1656532 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1637261 1637261 1553309 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096023 2096023 1974087 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535048 1535048 1457383 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-073-tumor 2819009 2675308 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2136667 2136667 2006218 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2552463 2552463 2413904 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27553514 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279085 1279085 1190381 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed metastasis 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1434019 1434019 1343434 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899316 899316 816928 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625553 2625553 2485965 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625553 2625553 2485965 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879557 1879557 1770059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2239176 2239176 2106708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51778029 COSM6268 99381060 c.2257C>T p.P753S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 47 ENSP00000275493.2:p.Pro753Ser ENST00000275493.6:c.2257C>T 7:g.55174794C>T EGFR ENST00000275493.6 3633 3236 1879506 1879506 1770008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602807 1602807 1522143 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1320681 1320681 1231568 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20155428 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983753 1983753 1869989 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899319 899319 816931 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668460 1668460 1581753 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1746667 1746667 1651643 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 1246716 1246716 1158395 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838645 1838645 1732746 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148624 2148624 2017754 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705487 1705487 1613393 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2136618 2136618 2006169 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS 84 ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-16-R00716 2905308 2759564 gastrointestinal_tract_(site_indeterminate) NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1813215 1813215 1712549 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23079729 surgery - NOS metastasis 42 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226863 2226863 2094598 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 587256 1766760 1671080 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51771628 COSM1205054 132552472 c.1876C>T p.R626C Substitution - Missense 38 7:55173074-55173074 + - PATHOGENIC .99716 Reported in another cancer sample as somatic 22895193 surgery fresh/frozen primary ENSP00000395243.3:p.Arg626Cys ENST00000454757.6:c.1876C>T 7:g.55173074C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891318 1891318 1780687 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 132551401 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Arg731His ENST00000454757.6:c.2192G>A 7:g.55181336G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862713 2862713 2717876 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780877 COSM26717 132548732 c.2444A>T p.K815I Substitution - Missense 38 7:55191828-55191828 + - PATHOGENIC .95726 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Lys815Ile ENST00000454757.6:c.2444A>T 7:g.55191828A>T EGFR ENST00000275493.6 3633 3236 1479098 1479098 1402791 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046038 2046038 1926333 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345099 2345099 2209771 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2862730 2862730 2717893 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1998744 1998744 1883816 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 23937608 surgery-fixed primary 64 ENSP00000275493.2:p.Glu709Lys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862713 2862713 2717876 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862784 2862784 2717947 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862784 2862784 2717947 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1295349 1295349 1206428 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 19884551 surgery fresh/frozen NS ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 1498198 1498198 1421076 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21220471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1694971 1694971 1603191 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1991297 1991297 1876632 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226887 2226887 2094622 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1046993 1046993 963224 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1631956 1631956 1548826 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 907085 907085 824597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 RPMI-8226 1092628 1007450 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS n COSV51773111 COSM13185 132548474 c.2117C>T p.T706I Substitution - Missense het 38 7:55174789-55174789 + - PATHOGENIC .99151 Reported in another cancer sample as somatic 18006781 cell-line NS ENSP00000395243.3:p.Thr706Ile ENST00000454757.6:c.2117C>T 7:g.55174789C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899328 899328 816940 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2026148 2026148 1908237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602796 1602796 1522132 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1891291 1891291 1780660 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895091 1895091 1783783 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1054403 1054403 970474 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1202556 1202556 1114442 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-64-1681-01 1914034 1802316 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 61 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1174295 1174295 1086314 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096152 2096152 1974216 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430031 1430031 1339449 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638750 1638750 1554749 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895117 1895117 1783809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891265 1891265 1780634 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983728 1983728 1869964 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077330 1077330 992584 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042899 1042899 959240 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471802 1471802 1395540 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51780206 COSM12373 132553376 c.2024C>T p.S675F Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .9768 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000395243.3:p.Ser675Phe ENST00000454757.6:c.2024C>T 7:g.55174018C>T EGFR ENST00000275493.6 3633 3236 1107251 1107251 1021163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1891179 1891179 1780548 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602811 1602811 1522147 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042907 1042907 959248 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 914807 914807 832256 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SH-437 1493307 1416297 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51773049 COSM22943 132549396 c.2408C>T p.P803L Substitution - Missense het 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 21372829 cell-line primary 49 ENSP00000395243.3:p.Pro803Leu ENST00000454757.6:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1088971 1088971 1003925 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17917328 cerebrospinal fluid metastasis 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00329T00329 2857335 2712635 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-18-M09457 2905536 2759792 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2819307 2819307 2675606 lung left_upper_lobe NS NS carcinoma invasive_mucinous_adenocarcinoma NS NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 30572543 circulating tumour NS 80 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983781 1983781 1870017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1231319 1231319 1143109 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 911619 911619 829102 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2239176 2239176 2106708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 47 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1067043 1067043 983023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875365 1875365 1765948 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450925 1450925 1375068 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 61 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1202552 1202552 1114438 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602804 1602804 1522140 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453421 1453421 1377454 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1110468 1110468 1024346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920167 920167 837247 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1751712 1751712 1656528 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064720 2064720 1944797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2538972 2538972 2400568 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 132550443 c.2104_2105delinsCC p.L702P Substitution - Missense het 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 27499993 surgery-fixed NS 61 ENSP00000395243.3:p.Leu702Pro ENST00000454757.6:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR ENST00000275493.6 3633 3236 TCGA-05-5423-01 1780079 1684078 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 65 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1891297 1891297 1780666 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1803420 1803420 1705109 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 23139670 surgery - NOS metastasis 57 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2069649 2069649 1949054 skin NS NS NS malignant_melanoma acral_lentiginous NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22437319 surgery-fixed primary 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1547762 1547762 1469884 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 47 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2680467 2680467 2539740 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 31 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1246688 1246688 1158367 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1468087 1468087 1391933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027732 2027732 1909635 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746654 1746654 1651630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2485106 2485106 2347806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 20630828 NS recurrent 67 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525679 2525679 2387868 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2665662 2665662 2525371 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28978102 surgery - NOS metastasis 66 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2675679 2675679 2534953 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29100434 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422834 2422834 2285756 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 273T 910551 828036 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766928 COSM12718 133206642 c.2045A>G p.Y682C Substitution - Missense het 38 7:55174039-55174039 + - PATHOGENIC .97626 Reported in another cancer sample as somatic 15735034 cell-line NS ENSP00000415559.1:p.Tyr682Cys ENST00000455089.5:c.2045A>G 7:g.55174039A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899356 899356 816968 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51780206 COSM12373 133208468 c.2024C>T p.S675F Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .9768 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Ser675Phe ENST00000455089.5:c.2024C>T 7:g.55174018C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625600 2625600 2486012 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 44 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631937 1631937 1548807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450939 1450939 1375082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 46 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1991300 1991300 1876635 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875347 1875347 1765930 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1194730 1194730 1106625 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1895171 1895171 1783863 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1576781 1576781 1498222 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 77 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226768 2226768 2094503 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2770735 2770735 2628936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM30754 178378833 c.? p.L747P Substitution - Missense + - Reported in another cancer sample as somatic 25403583 surgery-fixed recurrent 37 ENSP00000275493.2:p.Leu747Pro EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2432377 2432377 2295280 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 26473643 surgery fresh/frozen metastasis 53 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980068 1980068 1866311 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 72 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980066 1980066 1866309 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 56 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891336 1891336 1780705 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1522946 1522946 1445318 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 56 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 109600 2812903 2669317 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 46 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1876988 1876988 1767550 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453427 1453427 1377460 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1667642 1667642 1580937 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22534670 surgery-fixed NS 40 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302292 1302292 1213343 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879539 1879539 1770041 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1043125 1043125 959466 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 43 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1980063 1980063 1866306 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 60 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1522949 1522949 1445321 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 74 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1660248 1660248 1574521 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM24429 178380423 c.? p.E709G Substitution - Missense + - Reported in another cancer sample as somatic 21411993 surgery-fixed NS ENSP00000275493.2:p.Glu709Gly EGFR ENST00000275493.6 3633 3236 2664376 2664376 2524430 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 54 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2728326 2728326 2587139 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28413660 surgery - NOS recurrent 59 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618653 1618653 1537405 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 83 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618664 1618664 1537416 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 84 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2485110 2485110 2347810 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 20630828 NS recurrent 60 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CT13 1063196 979241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 57 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897800 897800 815422 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1789314 1789314 1692718 lung NS NS NS carcinoma NS NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239180 2239180 2106712 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 64 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239180 2239180 2106712 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103765 1103765 1018017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-16-G44694 2905057 2759313 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983748 1983748 1869984 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983709 1983709 1869945 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2595761 2595761 2456637 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2345100 2345100 2209772 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2264382 2264382 2131366 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2425751 2425751 2288672 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096114 2096114 1974178 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014320 1014320 931494 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770682 1770682 1674922 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591036 1591036 1512152 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1036704 1036704 953461 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17106442 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027809 2027809 1909712 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469176 1469176 1392915 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21130517 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1140944 1140944 1053392 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448998 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290964 2290964 2157029 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422783 2422783 2285705 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345798 2345798 2210470 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705522 1705522 1613428 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1355112 1355112 1265207 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921951 1921951 1809269 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990902 1990902 1876237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983697 1983697 1869933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009139 2009139 1891873 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602813 1602813 1522149 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2675406 2675406 2534680 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2595742 2595742 2456618 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS 85 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1770563 1770563 1674803 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2697836 2697836 2556740 breast NS NS NS carcinoma NS NS NS n COSV51788004 COSM6906202 132596191 c.3055A>G p.S1019G Substitution - Missense 38 7:55202544-55202544 + - PATHOGENIC .8902 Variant of unknown origin 29349598 NS NS ENSP00000395243.3:p.Ser1019Gly ENST00000454757.6:c.3055A>G 7:g.55202544A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2579439 2579439 2440776 NS NS NS NS malignant_melanoma NS NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2579439 2579439 2440776 NS NS NS NS malignant_melanoma NS NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 2025404 2025404 1907493 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535038 1535038 1457373 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1516784 1516784 1439378 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21575212 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618049 1618049 1536845 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476888 2476888 2339657 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618892 1618892 1537644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246629 1246629 1158308 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290966 2290966 2157031 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246688 1246688 1158367 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618056 1618056 1536852 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2595761 2595761 2456637 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2865246 2865246 2720376 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29413048 surgery-fixed primary 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729981 1729981 1635952 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459516 1459516 1383459 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469351 1469351 1393090 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476882 2476882 2339651 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264142 2264142 2131126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1029249 1029249 946120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16921488 pleural effusion NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2788068 2788068 2645486 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29308976 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000181 2000181 1885079 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986170 1986170 1872406 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1746654 1746654 1651630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680748 2680748 2540021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000184 2000184 1885082 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 591-90 2605266 2466157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25376516 surgery - NOS NS 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2028989 2028989 1910871 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656106 1656106 1570763 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21311943 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960186 1960186 1846826 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493362 1493362 1416352 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1962800 1962800 1849348 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23769878 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2082000 2082000 1960422 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24443522 surgery - NOS NS 70 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879508 1879508 1770010 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891244 1891244 1780613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897850 897850 815472 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51771864 COSM6226 132555722 c.2191C>T p.R731C Substitution - Missense 38 7:55181335-55181335 + - PATHOGENIC .97187 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Arg731Cys ENST00000454757.6:c.2191C>T 7:g.55181335C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897850 897850 815472 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51804843 COSM12429 132553900 c.2438_2439delinsGT p.L813R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438_2439delinsGT 7:g.55191822_55191823delinsGT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098817 1098817 1013409 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 51 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2241822 2241822 2109353 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25228365 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264319 2264319 2131303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226167 2226167 2093902 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000245 2000245 1885143 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1877569 1877569 1768130 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23408463 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237695 1237695 1149442 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278187 1278187 1189485 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430041 1430041 1339459 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542345 1542345 1464648 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1653410 1653410 1568197 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22333630 NS NS 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525679 2525679 2387868 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770588 1770588 1674828 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777311 1777311 1681314 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937516 1937516 1824450 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1855996 1855996 1748549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096150 2096150 1974214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 18 2570181 2431478 skin face NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51773206 COSM28603 99389206 c.2293G>A p.V765M Substitution - Missense 38 7:55181302-55181302 + - PATHOGENIC .97963 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 53 ENSP00000275493.2:p.Val765Met ENST00000275493.6:c.2293G>A 7:g.55181302G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429297 1429297 1338748 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-150-tumor 2819055 2675354 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136887 1136887 1049451 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226888 2226888 2094623 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1676432 1676432 1589200 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000253 2000253 1885151 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891165 1891165 1780534 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625561 2625561 2485973 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 51 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1036697 1036697 953454 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17106442 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983141 983141 898859 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240546 2240546 2108077 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25227801 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469465 1469465 1393204 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264139 2264139 2131123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937584 1937584 1824518 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264143 2264143 2131127 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637117 1637117 1553165 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1135349 1135349 1047915 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17591931 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914920 1914920 1802922 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422834 2422834 2285756 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083804 1083804 998969 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459501 1459501 1383444 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844334 1844334 1737368 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965883 1965883 1852376 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1672412 1672412 1585466 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21729655 surgery-fixed primary 94 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591059 1591059 1512175 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422794 2422794 2285716 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2156995 2156995 2025970 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965889 1965889 1852382 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522880 1522880 1445252 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965888 1965888 1852381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096217 2096217 1974281 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430046 1430046 1339464 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096182 2096182 1974246 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2033582 2033582 1915031 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24137397 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618653 1618653 1537405 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 83 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2644114 2644114 2504401 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1514600 1514600 1437210 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21558399 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618664 1618664 1537416 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 84 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838686 1838686 1732787 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2485110 2485110 2347810 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20630828 NS recurrent 60 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895171 1895171 1783863 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-05-5423-01 1780079 1684078 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 65 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891297 1891297 1780666 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1196037 1196037 1107932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19272767 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592995 1592995 1513921 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2479708 2479708 2342454 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1694973 1694973 1603193 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879555 1879555 1770057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2161694 2161694 2030301 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24813888 surgery fresh/frozen recurrent 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2161694 2161694 2030301 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 24813888 surgery fresh/frozen recurrent 58 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103627 1103627 1017879 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 59 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1242316 1242316 1154046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777111 COSM33725 99387470 c.2609A>G p.H870R Substitution - Missense het 38 7:55191858-55191858 + - PATHOGENIC .97748 Reported in another cancer sample as somatic 19671738 surgery-fixed primary 56 ENSP00000275493.2:p.His870Arg ENST00000275493.6:c.2609A>G 7:g.55191858A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372778 2372778 2235571 pleura NS NS NS mesothelioma NS NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24569782 surgery-fixed NS 85 ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879483 1879483 1769985 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1733456 1733456 1639405 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779524 COSM18425 133207486 c.2021G>A p.G674D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Reported in another cancer sample as somatic 22821383 surgery-fixed primary ENSP00000415559.1:p.Gly674Asp ENST00000455089.5:c.2021G>A 7:g.55174015G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 907081 907081 824593 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897802 897802 815424 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2402750 2402750 2265603 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 26267891 surgery-fixed primary 72 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897846 897846 815468 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2046186 2046186 1926481 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345802 2345802 2210474 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862714 2862714 2717877 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862714 2862714 2717877 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 133222251 c.2146G>T p.D716Y Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99554 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Asp716Tyr ENST00000455089.5:c.2146G>T 7:g.55174818G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479920 1479920 1403580 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773712 COSM13433 132558066 c.2183A>G p.H728R Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98391 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.His728Arg ENST00000454757.6:c.2183A>G 7:g.55181327A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675372 2675372 2534646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 132549396 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000395243.3:p.Pro803Leu ENST00000454757.6:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453491 1453491 1377524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042856 1042856 959197 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2680491 2680491 2539764 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 75 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1697982 1697982 1606100 salivary_gland NS NS NS carcinoma acinic_cell_carcinoma NS NS n COSV51773049 COSM22943 133204348 c.2408C>T p.P803L Substitution - Missense het 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 22694907 surgery-fixed NS ENSP00000415559.1:p.Pro803Leu ENST00000455089.5:c.2408C>T 7:g.55191792C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891323 1891323 1780692 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879559 1879559 1770061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1235138 1235138 1146924 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 53 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980072 1980072 1866315 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 71 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103803 1103803 1018055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00300T00300 2857355 2712655 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 587376 1766805 1671125 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51771628 COSM1205054 132552472 c.1876C>T p.R626C Substitution - Missense 38 7:55173074-55173074 + - PATHOGENIC .99716 Reported in another cancer sample as somatic 22895193 surgery fresh/frozen primary ENSP00000395243.3:p.Arg626Cys ENST00000454757.6:c.1876C>T 7:g.55173074C>T EGFR ENST00000275493.6 3633 3236 1475456 1475456 1399155 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2290969 2290969 2157034 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2096226 2096226 1974290 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2047820 2047820 1928092 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042918 1042918 959259 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1141185 1141185 1053633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 18785203 autopsy-fixed NS 64 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226869 2226869 2094604 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897804 897804 815426 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008349-T01-IM5 2724478 2583299 haematopoietic_and_lymphoid_tissue lymph_node NS NS lymphoid_neoplasm angioimmunoblastic_T_cell_lymphoma NS NS n COSV51806667 COSM6987130 133226220 c.1804G>A p.A602T Substitution - Missense het 38 7:55173002-55173002 + - PATHOGENIC .99609 Reported in another cancer sample as somatic 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala602Thr ENST00000455089.5:c.1804G>A 7:g.55173002G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593002 1593002 1513928 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1567522 1567522 1489154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21949883 fine needle aspirate metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345092 2345092 2209764 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2046187 2046187 1926482 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1515269 1515269 1437879 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2264376 2264376 2131360 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2007939 2007939 1890674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23907151 fine needle aspirate primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2661744 2661744 2521882 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28891180 surgery - NOS metastasis 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1675617 1675617 1588497 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22560922 surgery-fixed primary 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346543 2346543 2211206 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174324 1174324 1086343 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1697229 1697229 1605347 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21616658 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924513 924513 841286 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043133 1043133 959474 upper_aerodigestive_tract tonsil NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51771943 COSM22953 133226746 c.2266T>C p.Y756H Substitution - Missense 38 7:55181410-55181410 + - PATHOGENIC .96426 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 62 ENSP00000415559.1:p.Tyr756His ENST00000455089.5:c.2266T>C 7:g.55181410T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2509042 2509042 2371377 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 132551880 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 74 ENSP00000395243.3:p.Thr218Pro ENST00000454757.6:c.652A>C 7:g.55154050A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631938 1631938 1548808 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110458 1110458 1024336 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1731607 1731607 1637573 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 132550443 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 22797155 fixed - NOS NS 59 ENSP00000395243.3:p.Leu702Pro ENST00000454757.6:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR ENST00000275493.6 3633 3236 2476908 2476908 2339677 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM24429 178380423 c.? p.E709G Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Glu709Gly EGFR ENST00000275493.6 3633 3236 2476908 2476908 2339677 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777376 1777376 1681379 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965867 1965867 1852360 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459498 1459498 1383441 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879527 1879527 1770029 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226896 2226896 2094631 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479952 1479952 1403612 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1919304 1919304 1806625 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51803771 COSM14068 132563495 c.2173G>A p.D725N Substitution - Missense 38 7:55181317-55181317 + - PATHOGENIC .97623 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Asp725Asn ENST00000454757.6:c.2173G>A 7:g.55181317G>A EGFR ENST00000275493.6 3633 3236 1481252 1481252 1404881 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1325686 1325686 1236182 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 20215545 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879575 1879575 1770077 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879574 1879574 1770076 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980080 1980080 1866323 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 43 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1816950 1816950 1716118 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1576784 1576784 1498225 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 surgery - NOS primary 60 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226915 2226915 2094650 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777782 COSM6227 133210005 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.His790Leu ENST00000455089.5:c.2369A>T 7:g.55191753A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1047003 1047003 963234 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1435988 1435988 1345267 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen NS 48 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895070 1895070 1783762 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043857 1043857 960198 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1932133 1932133 1819406 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23632273 surgery fresh/frozen metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1530999 1530999 1453371 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1882247 1882247 1772398 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23392229 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2672941 2672941 2532450 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM34166 178380439 c.? p.R108K Substitution - Missense + - Reported in another cancer sample as somatic 26191234 surgery-fixed primary ENSP00000275493.2:p.Arg108Lys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AS-3778-01 1779806 1683805 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51831642 COSM1496684 133216418 c.853G>A p.E285K Substitution - Missense 38 7:55155928-55155928 + - PATHOGENIC .94538 Reported in another cancer sample as somatic 416 fresh/frozen - NOS primary 35 ENSP00000415559.1:p.Glu285Lys ENST00000455089.5:c.853G>A 7:g.55155928G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089598 1089598 1004545 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983775 1983775 1870011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594596 1594596 1515564 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1465897 1465897 1389744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 62 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2733582 2733582 2592335 central_nervous_system brain NS NS glioma NS NS NS n COSM34167 178379046 c.? p.G598V Substitution - Missense + - Reported in another cancer sample as somatic 29683790 surgery - NOS recurrent ENSP00000275493.2:p.Gly598Val EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602797 1602797 1522133 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043131 1043131 959472 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51789261 COSM12986 133218176 c.2294G>A p.G765D Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98244 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 49 ENSP00000415559.1:p.Gly765Asp ENST00000455089.5:c.2294G>A 7:g.55181438G>A EGFR ENST00000275493.6 3633 3236 1043133 1043133 959474 upper_aerodigestive_tract tonsil NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51771943 COSM22953 99401367 c.2401T>C p.Y801H Substitution - Missense 38 7:55181410-55181410 + - PATHOGENIC .96426 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 62 ENSP00000275493.2:p.Tyr801His ENST00000275493.6:c.2401T>C 7:g.55181410T>C EGFR ENST00000275493.6 3633 3236 2027803 2027803 1909706 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1694974 1694974 1603194 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 47 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2079983 2079983 1958545 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24412619 surgery - NOS recurrent 68 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1965352 1965352 1851847 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23726527 surgery-fixed NS 68 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1965352 1965352 1851847 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726527 surgery-fixed NS 68 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891282 1891282 1780651 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1200920 1200920 1112810 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1295349 1295349 1206428 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777782 COSM6227 99381636 c.2504A>T p.H835L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 19884551 surgery fresh/frozen NS ENSP00000275493.2:p.His835Leu ENST00000275493.6:c.2504A>T 7:g.55191753A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2552054 2552054 2413495 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51776282 COSM1168015 132547141 c.2123C>T p.P708L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Reported in another cancer sample as somatic 26517354 surgery-fixed NS ENSP00000395243.3:p.Pro708Leu ENST00000454757.6:c.2123C>T 7:g.55174795C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453433 1453433 1377466 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1751715 1751715 1656531 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891189 1891189 1780558 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920161 920161 837241 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895106 1895106 1783798 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924509 924509 841282 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450853 1450853 1374996 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862078 2862078 2717283 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 32122695 circulating tumour metastasis 62 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136862 1136862 1049426 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895138 1895138 1783830 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770693 1770693 1674933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475401 1475401 1399100 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1592990 1592990 1513916 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2153073 2153073 2022083 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899358 899358 816970 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1066987 1066987 982967 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17504988 surgery-fixed NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1974002 1974002 1860244 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773712 COSM13433 133214162 c.2183A>G p.H728R Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98391 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000415559.1:p.His728Arg ENST00000455089.5:c.2183A>G 7:g.55181327A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0154-01 1910182 1798473 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense hom 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 55 ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042857 1042857 959198 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302245 1302245 1213296 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS 39 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231327 1231327 1143117 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1188174 1188174 1100073 thyroid NS NS NS carcinoma papillary_carcinoma follicular_variant NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19253367 surgery-fixed primary 76 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1310469 1310469 1221414 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602803 1602803 1522139 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136879 1136879 1049443 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098871 1098871 1013463 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067066 1067066 983046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1310478 1310478 1221423 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983820 1983820 1870056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429326 1429326 1338777 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983732 1983732 1869968 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1994213 1994213 1879468 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23897956 surgery - NOS metastasis 56 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC2/Ad 946052 862578 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891208 1891208 1780577 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983821 1983821 1870057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1074941 1074941 990195 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891302 1891302 1780671 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1500181 1500181 1423060 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 53 1858567 1750785 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM34167 178379046 c.? p.G598V Substitution - Missense + - Reported in another cancer sample as somatic 23262510 short-term culture NS 59 ENSP00000275493.2:p.Gly598Val EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2027347 2027347 1909415 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 52 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1751710 1751710 1656526 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1693733 1693733 1601960 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21729654 surgery-fixed primary 65 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136869 1136869 1049433 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2026215 2026215 1908304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768262 COSM26445 132550179 c.2165C>T p.A722V Substitution - Missense het 38 7:55181309-55181309 + - PATHOGENIC .97799 Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000395243.3:p.Ala722Val ENST00000454757.6:c.2165C>T 7:g.55181309C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-E01014 1765085 1669405 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 60 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1983715 1983715 1869951 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-38-4627-01 1780091 1684090 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 PC-9 946058 862584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895104 1895104 1783796 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136876 1136876 1049440 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 21 1433986 1343401 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899329 899329 816941 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895136 1895136 1783828 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1631959 1631959 1548829 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924525 924525 841298 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453423 1453423 1377456 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920133 920133 837213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875374 1875374 1765957 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895086 1895086 1783778 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1083997 1083997 999162 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17785547 surgery fresh/frozen primary 52 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895107 1895107 1783799 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042909 1042909 959250 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897833 897833 815455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231310 1231310 1143100 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1435975 1435975 1345254 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery-fixed primary 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1107247 1107247 1021159 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1625788 1625788 1543012 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891230 1891230 1780599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891248 1891248 1780617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042906 1042906 959247 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453415 1453415 1377448 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860423 1860423 1751364 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983729 1983729 1869965 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136890 1136890 1049454 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009150 2009150 1891884 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891241 1891241 1780610 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675155 2675155 2534429 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766284 COSM28512 133205611 c.2095A>G p.I699V Substitution - Missense 38 7:55174767-55174767 + - PATHOGENIC .99591 Reported in another cancer sample as somatic 29075127 surgery fresh/frozen NS ENSP00000415559.1:p.Ile699Val ENST00000455089.5:c.2095A>G 7:g.55174767A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625563 2625563 2485975 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 51 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1046995 1046995 963226 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1625789 1625789 1543013 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895101 1895101 1783793 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895092 1895092 1783784 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1500180 1500180 1423059 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1043871 1043871 960212 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302278 1302278 1213329 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983735 1983735 1869971 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1320683 1320683 1231570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20155428 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1549817 1549817 1471922 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 82 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1881380 1881380 1771531 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891257 1891257 1780626 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1931641 1931641 1818931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1790525 1790525 1693504 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16152581 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631961 1631961 1548831 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226140 2226140 2093875 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770646 1770646 1674886 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083352 1083352 998517 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17596643 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346545 2346545 2211208 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096165 2096165 1974229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479949 1479949 1403609 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625551 2625551 2485963 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895103 1895103 1783795 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983726 1983726 1869962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924331 924331 841106 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631942 1631942 1548812 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1530684 1530684 1453056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21227397 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479915 1479915 1403575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1789320 1789320 1692724 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897824 897824 815446 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450858 1450858 1375001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1456618 1456618 1380593 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659804 2659804 2519962 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1894920 1894920 1783612 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895161 1895161 1783853 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2156366 2156366 2025374 lung left_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24752053 surgery - NOS primary 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879240 1879240 1769795 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23468066 pleural effusion NS 73 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2676600 2676600 2535874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 28939152 NS NS 35 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920158 920158 837238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 67 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00414T00414 2857361 2712661 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-075-tumor 2819011 2675310 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891290 1891290 1780659 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897816 897816 815438 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1197363 1197363 1109258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899343 899343 816955 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891226 1891226 1780595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897837 897837 815459 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875796 1875796 1766379 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231324 1231324 1143114 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593026 1593026 1513952 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983690 1983690 1869926 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875358 1875358 1765941 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2815032 2815032 2671420 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51787507 COSM13188 132557864 c.2146G>A p.D716N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 31400926 surgery-fixed NS 56 ENSP00000395243.3:p.Asp716Asn ENST00000454757.6:c.2146G>A 7:g.55174818G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1876998 1876998 1767560 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CT13 1063196 979241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 57 ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 MG-018-tumor 2818983 2675282 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00264T00264 2857327 2712627 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 V43 1179744 1091706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 82 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136895 1136895 1049459 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891267 1891267 1780636 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1435992 1435992 1345271 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen NS 85 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 907086 907086 824598 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-230-tumor 2819105 2675404 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-174-tumor 2819067 2675366 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897849 897849 815471 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897849 897849 815471 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895087 1895087 1783779 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891221 1891221 1780590 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226914 2226914 2094649 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 1980065 1980065 1866308 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 75 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879548 1879548 1770050 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1024758 1024758 941735 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 surgery fresh/frozen metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1576787 1576787 1498228 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 65 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1043871 1043871 960212 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1522942 1522942 1445314 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 56 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2026143 2026143 1908232 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 2862261 2862261 2717451 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25969368 surgery-fixed primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2045966 2045966 1926261 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451207 1451207 1375350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1960185 1960185 1846825 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174312 1174312 1086331 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770547 1770547 1674787 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-014-tumor 2818981 2675280 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899356 899356 816968 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766618 COSM12374 133206840 c.2447T>G p.L816R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu816Arg ENST00000455089.5:c.2447T>G 7:g.55191831T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778597 2778597 2636651 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51859563 COSM6910210 132549516 c.2374G>A p.D792N Substitution - Missense 38 7:55191758-55191758 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000395243.3:p.Asp792Asn ENST00000454757.6:c.2374G>A 7:g.55191758G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098865 1098865 1013457 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136880 1136880 1049444 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077339 1077339 992593 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453428 1453428 1377461 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1567521 1567521 1489153 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21949883 fine needle aspirate metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136871 1136871 1049435 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2824230 2824230 2680047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 31542322 circulating tumour recurrent 52 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1602810 1602810 1522146 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-111-tumor 2819034 2675333 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00227T00227 2857348 2712648 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1558204 1558204 1479575 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21835826 surgery - NOS primary 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098813 1098813 1013405 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 52 ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098813 1098813 1013405 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 52 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2027348 2027348 1909416 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 52 ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980079 1980079 1866322 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 71 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064723 2064723 1944800 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1 1433966 1343381 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1534107 1534107 1456446 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21707848 surgery-fixed metastasis 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226872 2226872 2094607 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862728 2862728 2717891 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1991301 1991301 1876636 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2758808 2758808 2617370 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28762784 fine needle aspirate metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2078351 2078351 1957070 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24314215 pleural effusion NS 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891228 1891228 1780597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1038995 1038995 955572 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1876985 1876985 1767547 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1573765 1573765 1495234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21982684 surgery fresh/frozen metastasis 44 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895073 1895073 1783765 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1000057 1000057 917280 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875354 1875354 1765937 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1074946 1074946 990200 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-91-6847-01 1914094 1802376 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 62 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077372 1077372 992626 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-043-tumor 2818993 2675292 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00005T00005 2857374 2712674 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1844516 1844516 1737550 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23154768 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2906657 2906657 2760908 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29616327 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027859 2027859 1909762 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2809830 2809830 2666498 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 31315676 cerebrospinal fluid recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2552450 2552450 2413891 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27553514 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2637644 2637644 2498017 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 67 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618759 1618759 1537511 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 61 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422831 2422831 2285753 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1610404 1610404 1529644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22142557 pleural effusion NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264421 2264421 2131405 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2264379 2264379 2131363 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2778780 2778780 2636834 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 29066915 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1837415 1837415 1731614 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23242437 NS NS 63 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1325686 1325686 1236182 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 20215545 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2862770 2862770 2717933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 99388191 c.2389T>A p.C797S Substitution - Missense 38 7:55181398-55181398 + - PATHOGENIC .95568 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2389T>A 7:g.55181398T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983779 1983779 1870015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899356 899356 816968 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766618 COSM12374 99378740 c.2582T>G p.L861R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Arg ENST00000275493.6:c.2582T>G 7:g.55191831T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 109596 2812901 2669315 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 72 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 G36 1063244 979289 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 73 ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 1074945 1074945 990199 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 44 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895113 1895113 1783805 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2148627 2148627 2017757 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2406833 2406833 2269713 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 48 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1997144 1997144 1882353 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23930206 fixed - NOS primary 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1102393 1102393 1016645 lung left_lower_lobe NS NS other hyperplasia NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18208799 surgery-fixed NS 53 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862078 2862078 2717283 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 32122695 circulating tumour metastasis 62 ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136889 1136889 1049453 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1054400 1054400 970471 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089603 1089603 1004550 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231313 1231313 1143103 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1168011 1168011 1080253 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 896926 896926 814549 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15329413 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1884156 1884156 1774043 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1973998 1973998 1860240 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009148 2009148 1891882 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1107246 1107246 1021158 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239189 2239189 2106721 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25134330 surgery - NOS NS 81 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2659795 2659795 2519953 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773049 COSM22943 99376120 c.2543C>T p.P848L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Pro848Leu ENST00000275493.6:c.2543C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 1734172 1734172 1640121 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22843912 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264353 2264353 2131337 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777349 1777349 1681352 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095986 2095986 1974050 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881887 1881887 1772038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937572 1937572 1824506 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1856199 1856199 1748752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346544 2346544 2211207 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2271431 2271431 2138060 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25257380 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638752 1638752 1554751 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2662907 2662907 2523029 kidney NS NS NS Wilms_tumour NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28326956 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1489668 1489668 1412826 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21155184 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476885 2476885 2339654 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011157 2011157 1893795 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264137 2264137 2131121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838643 1838643 1732744 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777231 1777231 1681234 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246615 1246615 1158294 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064710 2064710 1944787 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226870 2226870 2094605 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110455 1110455 1024333 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450934 1450934 1375077 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 49 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1135424 1135424 1047988 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924524 924524 841297 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920130 920130 837210 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891245 1891245 1780614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NCI-H3255 897734 815356 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15118125 cell-line metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226880 2226880 2094615 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592883 1592883 1513809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592883 1592883 1513809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 1444715 1444715 1368958 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264222 2264222 2131206 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618835 1618835 1537587 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618736 1618736 1537488 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844350 1844350 1737384 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345409 2345409 2210081 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777221 1777221 1681224 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479093 1479093 1402786 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965857 1965857 1852350 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770621 1770621 1674861 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468875 1468875 1392614 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21128242 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1894920 1894920 1783612 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1042856 1042856 959197 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1551476 1551476 1473581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1661846 1661846 1575459 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22487432 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729977 1729977 1635948 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474443 2474443 2337212 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891266 1891266 1780635 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2730698 2730698 2589469 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 132550443 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + Yes Reported in another cancer sample as somatic 29673089 surgery-fixed recurrent 54 ENSP00000395243.3:p.Leu702Pro ENST00000454757.6:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879552 1879552 1770054 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1435969 1435969 1345248 lung right_lower_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen primary 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899340 899340 816952 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895153 1895153 1783845 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770712 1770712 1674952 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025388 2025388 1907477 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329259 1329259 1239744 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618854 1618854 1537606 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1823858 1823858 1722252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23212424 surgery-fixed metastasis 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246699 1246699 1158378 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1213640 1213640 1125507 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18978556 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045979 2045979 1926274 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637089 1637089 1553137 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2809830 2809830 2666498 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31315676 cerebrospinal fluid recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937593 1937593 1824527 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2115447 2115447 1989691 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23915069 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106541 2106541 1984404 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469379 1469379 1393118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960167 1960167 1846807 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096011 2096011 1974075 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214532 2214532 2082656 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459495 1459495 1383438 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637078 1637078 1553126 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444720 1444720 1368963 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264156 2264156 2131140 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469481 1469481 1393220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444786 1444786 1369029 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983457 983457 899175 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637692 2637692 2498065 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 circulating tumour recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025390 2025390 1907479 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2728545 2728545 2587356 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29575765 surgery-fixed primary 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246690 1246690 1158369 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996579 1996579 1881788 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23922984 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618759 1618759 1537511 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2265097 2265097 2132001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994671 cerebrospinal fluid metastasis 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046618 2046618 1926912 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1465892 1465892 1389739 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1697233 1697233 1605351 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21616658 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469384 1469384 1393123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174308 1174308 1086327 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026252 2026252 1908341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637122 1637122 1553170 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1992087 1992087 1877404 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 42 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2203113 2203113 2071371 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083065 1083065 998230 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17685931 surgery-fixed NS 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1624153 1624153 1541740 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22000696 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770610 1770610 1674850 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422913 2422913 2285835 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346473 2346473 2211136 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264086 2264086 2131070 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2675155 2675155 2534429 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766268 COSM13183 99377562 c.2225T>C p.V742A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Reported in another cancer sample as somatic 29075127 surgery fresh/frozen NS ENSP00000275493.2:p.Val742Ala ENST00000275493.6:c.2225T>C 7:g.55174762T>C EGFR ENST00000275493.6 3633 3236 1469467 1469467 1393206 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2479705 2479705 2342451 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 NPC0002PT00015T00015 2857336 2712636 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1855971 1855971 1748524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS primary ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 2025405 2025405 1907494 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469394 1469394 1393133 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1168003 1168003 1080245 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19059670 surgery-fixed primary 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468091 1468091 1391937 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1246676 1246676 1158355 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246645 1246645 1158324 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1895147 1895147 1783839 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1664592 1664592 1578042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21899495 ascites NS 39 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2_48 2039533 1920866 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 132549396 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 24158511 surgery fresh/frozen primary 78 ENSP00000395243.3:p.Pro803Leu ENST00000454757.6:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1973997 1973997 1860239 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 NPC0001PT00226T00226 2857365 2712665 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 MG-087-tumor 2819019 2675318 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 MG-185-tumor 2819071 2675370 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136894 1136894 1049458 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766618 COSM12374 132551897 c.2447T>G p.L816R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu816Arg ENST00000454757.6:c.2447T>G 7:g.55191831T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009163 2009163 1891897 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239172 2239172 2106704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 58 ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239172 2239172 2106704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1522945 1522945 1445317 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 50 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980076 1980076 1866319 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 42 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 V169 1179750 1091712 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 42 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897820 897820 815442 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592985 1592985 1513911 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1160968 1160968 1073304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19002495 surgery-fixed primary 48 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 907084 907084 824596 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862707 2862707 2717870 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2778531 2778531 2636585 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51775222 COSM13189 99385712 c.2351C>T p.S784F Substitution - Missense 38 7:55181360-55181360 + - PATHOGENIC .94833 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000275493.2:p.Ser784Phe ENST00000275493.6:c.2351C>T 7:g.55181360C>T EGFR ENST00000275493.6 3633 3236 1246681 1246681 1158360 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549123 2549123 2410578 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1302244 1302244 1213295 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1093896 1093896 1008598 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18061305 pleural effusion NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1434027 1434027 1343442 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897284 897284 814907 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 15118073 surgery-fixed primary 62 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2810587 2810587 2667248 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51766268 COSM13183 132550670 c.2090T>C p.V697A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Reported in another cancer sample as somatic 31476386 surgery-fixed NS 67.2 ENSP00000395243.3:p.Val697Ala ENST00000454757.6:c.2090T>C 7:g.55174762T>C EGFR ENST00000275493.6 3633 3236 2476834 2476834 2339603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1517892 1517892 1440270 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21572125 fine needle aspirate NS 82 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1481232 1481232 1404861 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1547784 1547784 1469906 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 55 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2637642 2637642 2498015 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 59 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1444574 1444574 1368819 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 20686428 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525685 2525685 2387874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2680635 2680635 2539908 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 68 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032254 2032254 1913725 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746667 1746667 1651643 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1246686 1246686 1158365 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2865552 2865552 2720682 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 29120087 surgery-fixed metastasis 55 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2686013 2686013 2545048 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921955 1921955 1809273 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148613 2148613 2017743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1514592 1514592 1437202 lung right_lower_lobe NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21556797 surgery - NOS primary 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422939 2422939 2285861 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680730 2680730 2540003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1631949 1631949 1548819 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LUAD_E01166 1765174 1669494 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 22980975 surgery - NOS primary ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1937523 1937523 1824457 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914944 1914944 1802946 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077328 1077328 992582 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00296T00296 2857351 2712651 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983696 1983696 1869932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1789305 1789305 1692709 lung NS NS NS carcinoma NS NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1789305 1789305 1692709 lung NS NS NS carcinoma NS NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 1879240 1879240 1769795 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23468066 pleural effusion NS 73 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2676600 2676600 2535874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 28939152 NS NS 35 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 920158 920158 837238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 67 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1894920 1894920 1783612 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2027346 2027346 1909414 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 56 ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732920 2732920 2591673 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 132551880 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 73 ENSP00000395243.3:p.Thr218Pro ENST00000454757.6:c.652A>C 7:g.55154050A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594593 1594593 1515561 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891198 1891198 1780567 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2148648 2148648 2017778 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1875799 1875799 1766382 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-67-6217-01 1780210 1684209 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777304 1777304 1681307 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2089559 2089559 1967768 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24511003 surgery fresh/frozen NS 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881888 1881888 1772039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878852 2878852 2733367 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27368130 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290949 2290949 2157014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879497 1879497 1769999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879523 1879523 1770025 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2345063 2345063 2209735 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1770711 1770711 1674951 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770578 1770578 1674818 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680498 2680498 2539771 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 49 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2402517 2402517 2265373 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246689 1246689 1158368 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618651 1618651 1537403 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 58 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618651 1618651 1537403 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637181 1637181 1553229 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148615 2148615 2017745 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2152688 2152688 2021698 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24768118 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879237 1879237 1769792 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23468066 surgery-fixed NS 48 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891203 1891203 1780572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2860650 2860650 2715938 central_nervous_system choroid_plexus NS NS other choroid_plexus_papilloma NS NS n COSV51803731 COSM28604 99377260 c.2506C>T p.R836C Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .95213 Reported in another cancer sample as somatic 31612017 surgery-fixed NS 3 ENSP00000275493.2:p.Arg836Cys ENST00000275493.6:c.2506C>T 7:g.55191755C>T EGFR ENST00000275493.6 3633 3236 2226889 2226889 2094624 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891335 1891335 1780704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891335 1891335 1780704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2096183 2096183 1974247 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1000817 1000817 918040 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 16983123 autopsy - NOS metastasis 53 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302286 1302286 1213337 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166446 1166446 1078760 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00177T00177 2857368 2712668 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1515270 1515270 1437880 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2029030 2029030 1910912 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345073 2345073 2209745 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1937514 1937514 1824448 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731096 1731096 1637067 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22815900 fine needle aspirate metastasis ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 64 2786482 2643905 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51779794 COSM53264 132559797 c.2039C>T p.T680M Substitution - Missense 38 7:55174033-55174033 + - PATHOGENIC .97744 Reported in another cancer sample as somatic 30115035 surgery-fixed NS ENSP00000395243.3:p.Thr680Met ENST00000454757.6:c.2039C>T 7:g.55174033C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453436 1453436 1377469 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226891 2226891 2094626 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1074942 1074942 990196 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 80 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 G9 1063233 979278 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 G9 1063233 979278 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 63 ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 1777278 1777278 1681281 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1884044 1884044 1773933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23495083 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246486 1246486 1158165 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345420 2345420 2210092 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844336 1844336 1737370 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230455 1230455 1142269 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096061 2096061 1974125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1526362 1526362 1448730 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21623281 surgery - NOS primary 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264196 2264196 2131180 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425749 2425749 2288670 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029006 2029006 1910888 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587278 1587278 1508449 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676411 1676411 1589179 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479089 1479089 1402782 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914926 1914926 1802928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083059 1083059 998224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17685931 surgery-fixed NS 43 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000190 2000190 1885088 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983138 983138 898856 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838560 1838560 1732661 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444574 1444574 1368819 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20686428 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226176 2226176 2093911 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476855 2476855 2339624 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921907 1921907 1809225 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278194 1278194 1189492 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264339 2264339 2131323 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000187 2000187 1885085 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346480 2346480 2211143 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542348 1542348 1464651 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179664 1179664 1091626 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1812623 1812623 1711957 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23174717 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844514 1844514 1737548 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23154768 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924510 924510 841283 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2396139 2396139 2258970 lung left_bronchus NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24942894 fine needle aspirate recurrent 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2396139 2396139 2258970 lung left_bronchus NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 24942894 fine needle aspirate recurrent 70 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1024765 1024765 941742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 surgery-fixed recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895169 1895169 1783861 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1592994 1592994 1513920 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1444779 1444779 1369022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1355115 1355115 1265210 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345473 2345473 2210145 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862402 2862402 2717588 lung right_lower_lobe NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31561203 surgery - NOS NS 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1445169 1445169 1369412 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20592359 NS NS 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2151311 2151311 2020355 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24758910 NS NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469407 1469407 1393146 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047816 2047816 1928088 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921924 1921924 1809242 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214557 2214557 2082681 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264209 2264209 2131193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551552 1551552 1473657 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264108 2264108 2131092 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525715 2525715 2387903 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965850 1965850 1852343 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875346 1875346 1765929 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778775 2778775 2636829 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1751711 1751711 1656527 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226879 2226879 2094614 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00204T00204 2857356 2712656 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2095977 2095977 1974041 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026265 2026265 1908354 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179669 1179669 1091631 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026256 2026256 1908345 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1882448 1882448 1772584 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23379755 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345596 2345596 2210268 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665713 2665713 2525422 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS primary 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2562093 2562093 2423489 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914914 1914914 1802916 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1053135 1053135 969206 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17409961 surgery - NOS NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1465897 1465897 1389744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1512596 1512596 1435280 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21508367 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770632 1770632 1674872 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081931 2081931 1960353 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24440279 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875675 1875675 1766258 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1532701 1532701 1455061 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20925915 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046027 2046027 1926322 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246686 1246686 1158365 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264297 2264297 2131281 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2028992 2028992 1910874 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937577 1937577 1824511 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522883 1522883 1445255 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264098 2264098 2131082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676430 1676430 1589198 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637249 1637249 1553297 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1223896 1223896 1135728 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19517135 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2156999 2156999 2025974 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729954 1729954 1635925 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 surgery-fixed NS 72 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AP-A051-01 1783330 1687329 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51848796 COSM1090874 132560765 c.1186G>A p.V396I Substitution - Missense het 38 7:55160161-55160161 + - PATHOGENIC .92435 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000395243.3:p.Val396Ile ENST00000454757.6:c.1186G>A 7:g.55160161G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891206 1891206 1780575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592999 1592999 1513925 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659807 2659807 2519965 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983743 1983743 1869979 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1566948 1566948 1488717 upper_aerodigestive_tract pharynx hypopharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51804843 COSM12429 132553900 c.2438_2439delinsGT p.L813R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 21953075 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438_2439delinsGT 7:g.55191822_55191823delinsGT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136886 1136886 1049450 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766618 COSM12374 132551897 c.2447T>G p.L816R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu816Arg ENST00000454757.6:c.2447T>G 7:g.55191831T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990895 1990895 1876230 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2479703 2479703 2342449 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897808 897808 815430 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897821 897821 815443 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1075907 1075907 991161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 132565801 c.2146G>T p.D716Y Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99554 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000395243.3:p.Asp716Tyr ENST00000454757.6:c.2146G>T 7:g.55174818G>T EGFR ENST00000275493.6 3633 3236 2402489 2402489 2265345 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 74 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618799 1618799 1537551 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 47 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2104642 2104642 1982680 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24555578 pleural effusion recurrent 56 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2908022 2908022 2762205 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24457237 surgery-fixed recurrent 60 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 PC-9R 1890454 1779876 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22773810 cell-line NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1517401 1517401 1439785 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21610522 NS primary 60 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2345802 2345802 2210474 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879524 1879524 1770026 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2675155 2675155 2534429 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766284 COSM28512 99377567 c.2230A>G p.I744V Substitution - Missense 38 7:55174767-55174767 + - PATHOGENIC .99591 Reported in another cancer sample as somatic 29075127 surgery fresh/frozen NS ENSP00000275493.2:p.Ile744Val ENST00000275493.6:c.2230A>G 7:g.55174767A>G EGFR ENST00000275493.6 3633 3236 2426833 2426833 2289754 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2426833 2426833 2289754 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM5010368 178378709 c.? p.C797S Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Cys797Ser EGFR ENST00000275493.6 3633 3236 1931639 1931639 1818929 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891209 1891209 1780578 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990909 1990909 1876244 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983833 1983833 1870069 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862074 2862074 2717281 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 32122695 surgery - NOS NS 62 ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 1729755 1729755 1635726 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM26130 178380894 c.? p.L861P Substitution - Missense + - Reported in another cancer sample as somatic 22805266 NS NS EGFR ENST00000275493.6 3633 3236 2422806 2422806 2285728 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2240554 2240554 2108085 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25227801 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897836 897836 815458 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625550 2625550 2485962 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895120 1895120 1783812 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860428 1860428 1751369 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302291 1302291 1213342 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618014 1618014 1536810 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1465903 1465903 1389750 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 71 ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 6374 915984 833383 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51860329 COSM13190 133219847 c.2240T>C p.L747P Substitution - Missense 38 7:55181384-55181384 + - PATHOGENIC .95089 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000415559.1:p.Leu747Pro ENST00000455089.5:c.2240T>C 7:g.55181384T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990904 1990904 1876239 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862862 2862862 2718024 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29489023 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226914 2226914 2094649 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777782 COSM6227 132554599 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.His790Leu ENST00000454757.6:c.2369A>T 7:g.55191753A>T EGFR ENST00000275493.6 3633 3236 2260319 2260319 2127304 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25263855 fine needle aspirate NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1965831 1965831 1852324 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-02-0021-01 1910130 1798421 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 99380629 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 44 ENSP00000275493.2:p.Arg252Cys ENST00000275493.6:c.754C>T 7:g.55154017C>T EGFR ENST00000275493.6 3633 3236 921165 921165 838124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16002952 surgery-fixed primary 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591048 1591048 1512164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000161 2000161 1885059 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862111 2862111 2717313 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51788393 COSM13979 132563273 c.2035G>A p.G679S Substitution - Missense 38 7:55174029-55174029 + - PATHOGENIC .98273 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000395243.3:p.Gly679Ser ENST00000454757.6:c.2035G>A 7:g.55174029G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 22 1433987 1343402 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 79 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1676433 1676433 1589201 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770724 1770724 1674964 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986168 1986168 1872404 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729970 1729970 1635941 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535039 1535039 1457374 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777220 1777220 1681223 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637100 1637100 1553148 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045982 2045982 1926277 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777266 1777266 1681269 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045978 2045978 1926273 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618799 1618799 1537551 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 47 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444748 1444748 1368991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591042 1591042 1512158 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879424 1879424 1769929 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23464964 surgery-fixed NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914915 1914915 1802917 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1435654 1435654 1344933 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20661086 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045995 2045995 1926290 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173384 1173384 1085468 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887378 1887378 1777050 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878857 2878857 2733372 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27368130 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474446 2474446 2337215 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525686 2525686 2387875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770529 1770529 1674769 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264152 2264152 2131136 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 V197 1179751 1091713 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879532 1879532 1770034 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2474451 2474451 2337220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246658 1246658 1158337 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422806 2422806 2285728 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148609 2148609 2017739 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218525 2218525 2086536 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421164 2421164 2284086 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637062 1637062 1553110 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240665 2240665 2108196 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 43 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095965 2095965 1974029 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095914 2095914 1973978 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1997142 1997142 1882351 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23930206 fixed - NOS primary 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1697232 1697232 1605350 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21616658 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000207 2000207 1885105 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425720 2425720 2288641 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096162 2096162 1974226 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474459 2474459 2337228 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148612 2148612 2017742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937583 1937583 1824517 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1052965 1052965 969036 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17410005 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2819290 2819290 2675589 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 30711944 surgery - NOS NS 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1661839 1661839 1575452 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22487432 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551557 1551557 1473662 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096062 2096062 1974126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680549 2680549 2539822 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 42 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264211 2264211 2131195 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011176 2011176 1893814 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2686020 2686020 2545055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025396 2025396 1907485 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264242 2264242 2131226 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029009 2029009 1910891 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214572 2214572 2082696 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535040 1535040 1457375 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279051 1279051 1190347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed metastasis 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230479 1230479 1142293 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444741 1444741 1368984 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2908022 2908022 2762205 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457237 surgery-fixed recurrent 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705484 1705484 1613390 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547828 1547828 1469950 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937592 1937592 1824526 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914927 1914927 1802929 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659801 2659801 2519959 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EGCT1088 2490716 2353365 testis NS NS NS germ_cell_tumour choriocarcinoma NS NS n COSV51835294 COSM5749118 132582152 c.1588G>A p.G530R Substitution - Missense 38 7:55165280-55165280 + - PATHOGENIC .99792 Variant of unknown origin 26956871 surgery fresh/frozen primary ENSP00000395243.3:p.Gly530Arg ENST00000454757.6:c.1588G>A 7:g.55165280G>A EGFR ENST00000275493.6 3633 3236 1770564 1770564 1674804 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842963 1842963 1736211 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444722 1444722 1368965 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077340 1077340 992594 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891235 1891235 1780604 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875381 1875381 1765964 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1235133 1235133 1146919 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19589612 surgery - NOS recurrent 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618704 1618704 1537456 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1517401 1517401 1439785 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21610522 NS primary 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1672458 1672458 1585512 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21729655 fine needle aspirate primary 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095976 2095976 1974040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046613 2046613 1926907 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345506 2345506 2210178 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264099 2264099 2131083 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770535 1770535 1674775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860418 1860418 1751359 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 MG-171-tumor 2819064 2675363 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1891305 1891305 1780674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110470 1110470 1024348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1038993 1038993 955570 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983822 1983822 1870058 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2626119 2626119 2486531 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51779794 COSM53264 132559797 c.2039C>T p.T680M Substitution - Missense 38 7:55174033-55174033 + - PATHOGENIC .97744 Reported in another cancer sample as somatic 26645239 surgery-fixed NS ENSP00000395243.3:p.Thr680Met ENST00000454757.6:c.2039C>T 7:g.55174033C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1047909 1047909 964138 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17335935 pleural effusion primary 83 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239189 2239189 2106721 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 25134330 surgery - NOS NS 81 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1980073 1980073 1866316 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 69 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2226183 2226183 2093918 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1752348 1752348 1657159 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22912354 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729976 1729976 1635947 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1077370 1077370 992624 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1318769 1318769 1229667 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773049 COSM22943 133204348 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 19955396 surgery fresh/frozen NS ENSP00000415559.1:p.Pro803Leu ENST00000455089.5:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-103-tumor 2819029 2675328 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732919 2732919 2591672 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 132551880 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 73 ENSP00000395243.3:p.Thr218Pro ENST00000454757.6:c.652A>C 7:g.55154050A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1456556 1456556 1380531 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879533 1879533 1770035 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194729 1194729 1106624 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1319151 1319151 1230050 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20146086 surgery - NOS recurrent 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1319151 1319151 1230050 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 20146086 surgery - NOS recurrent 54 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-55-7573-01 1914019 1802301 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51830809 COSM85993 132579933 c.2125A>G p.K709E Substitution - Missense 38 7:55174797-55174797 + - PATHOGENIC .99211 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 72 ENSP00000395243.3:p.Lys709Glu ENST00000454757.6:c.2125A>G 7:g.55174797A>G EGFR ENST00000275493.6 3633 3236 1549822 1549822 1471927 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2730697 2730697 2589468 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 133205309 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + Yes Reported in another cancer sample as somatic 29673089 circulating tumour primary 54 ENSP00000415559.1:p.Leu702Pro ENST00000455089.5:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-49-4494-01 1780138 1684137 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 77 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-49-4494-01 1780138 1684137 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 77 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064703 2064703 1944780 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 946824 946824 863347 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1443062 1443062 1367347 lung left_upper_lobe NS NS carcinoma small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20837450 surgery - NOS metastasis 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990914 1990914 1876249 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895079 1895079 1783771 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453495 1453495 1377528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1089607 1089607 1004554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1046999 1046999 963230 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862715 2862715 2717878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CT19 1063199 979244 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983730 1983730 1869966 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1549824 1549824 1471929 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 85 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875344 1875344 1765927 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067064 1067064 983044 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1981026 1981026 1867262 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1534106 1534106 1456445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21707848 surgery-fixed primary 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875370 1875370 1765953 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1197351 1197351 1109246 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1648544 1648544 1563499 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1197353 1197353 1109248 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1043853 1043853 960194 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136884 1136884 1049448 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1052738 1052738 968809 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17368623 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1610918 1610918 1530146 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22157931 surgery-fixed primary 55 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891278 1891278 1780647 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1860424 1860424 1751365 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450943 1450943 1375086 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-91-6835-01 1780237 1684236 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 81 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983827 1983827 1870063 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AP-A0LM-01 1783352 1687351 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51797307 COSM1090871 133224328 c.1175C>A p.S392Y Substitution - Missense het 38 7:55160150-55160150 + - PATHOGENIC .98943 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 33 ENSP00000415559.1:p.Ser392Tyr ENST00000455089.5:c.1175C>A 7:g.55160150C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-44-6147-01 1780126 1684125 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51811749 COSM6242 133217384 c.2170G>T p.V724L Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .9836 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 67 ENSP00000415559.1:p.Val724Leu ENST00000455089.5:c.2170G>T 7:g.55181314G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1517053 1517053 1439647 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 49 ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891190 1891190 1780559 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920156 920156 837236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 51 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879486 1879486 1769988 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471792 1471792 1395530 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51779794 COSM53264 132559797 c.2039C>T p.T680M Substitution - Missense 38 7:55174033-55174033 + - PATHOGENIC .97744 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000395243.3:p.Thr680Met ENST00000454757.6:c.2039C>T 7:g.55174033C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098868 1098868 1013460 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875345 1875345 1765928 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895167 1895167 1783859 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LUAD-RT-S01771 1765129 1669449 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 48 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1876997 1876997 1767559 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1135422 1135422 1047986 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897285 897285 814908 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 15118073 surgery-fixed primary 58 ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1882510 1882510 1772646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51803731 COSM28604 133205257 c.2371C>T p.R791C Substitution - Missense het 38 7:55191755-55191755 + - PATHOGENIC .95213 Reported in another cancer sample as somatic 23486275 pleural effusion metastasis 81 ENSP00000415559.1:p.Arg791Cys ENST00000455089.5:c.2371C>T 7:g.55191755C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1078227 1078227 993477 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17626639 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2757127 2757127 2615769 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 29858019 ascites recurrent 50 ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2757127 2757127 2615769 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 133203995 c.2183A>T p.H728L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 29858019 ascites recurrent 50 ENSP00000415559.1:p.His728Leu ENST00000455089.5:c.2183A>T 7:g.55181327A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-44-6147-01 1780126 1684125 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 67 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1522948 1522948 1445320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 64 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453489 1453489 1377522 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226916 2226916 2094651 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239175 2239175 2106707 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 49 ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SK-MEL-28 1092633 1007455 skin NS NS NS malignant_melanoma NS NS NS n COSV51778029 COSM6268 132554063 c.2122C>T p.P708S Substitution - Missense hom 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 18006781 cell-line NS ENSP00000395243.3:p.Pro708Ser ENST00000454757.6:c.2122C>T 7:g.55174794C>T EGFR ENST00000275493.6 3633 3236 2465696 2465696 2328527 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26724810 surgery - NOS primary 70 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098876 1098876 1013468 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2422466 2422466 2285388 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25521406 surgery - NOS metastasis 65 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891311 1891311 1780680 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631948 1631948 1548818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879492 1879492 1769994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1024768 1024768 941745 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2778773 2778773 2636827 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2819302 2819302 2675601 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 30711944 pleural effusion recurrent 64 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2226915 2226915 2094650 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 1489861 1489861 1413019 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21224376 surgery-fixed recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899330 899330 816942 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239174 2239174 2106706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064709 2064709 1944786 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 HCC4006 2776305 2634441 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51830861 COSM6219 99378340 c.2248G>C p.A750P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Reported in another cancer sample as somatic 29681454 NS NS ENSP00000275493.2:p.Ala750Pro ENST00000275493.6:c.2248G>C 7:g.55174785G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1082437 1082437 997655 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17649787 autopsy-fixed recurrent 32 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891332 1891332 1780701 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879504 1879504 1770006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879502 1879502 1770004 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879518 1879518 1770020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924350 924350 841125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51804843 COSM12429 132553900 c.2438_2439delinsGT p.L813R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438_2439delinsGT 7:g.55191822_55191823delinsGT EGFR ENST00000275493.6 3633 3236 1733456 1733456 1639405 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779524 COSM18425 99379336 c.2156G>A p.G719D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Reported in another cancer sample as somatic 22821383 surgery-fixed primary ENSP00000275493.2:p.Gly719Asp ENST00000275493.6:c.2156G>A 7:g.55174015G>A EGFR ENST00000275493.6 3633 3236 2579341 2579341 2440678 NS NS NS NS malignant_melanoma NS NS NS n COSV51770777 COSM28286 99393107 c.2494C>T p.R832C Substitution - Missense 38 7:55191743-55191743 + - PATHOGENIC .95135 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000275493.2:p.Arg832Cys ENST00000275493.6:c.2494C>T 7:g.55191743C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2696524 2696524 2555428 central_nervous_system middle_frontal_gyrus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28201779 surgery fresh/frozen NS 56 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 6 1077305 992559 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51815927 COSM24971 133219942 c.2378T>C p.L793P Substitution - Missense 38 7:55191762-55191762 + - PATHOGENIC .97813 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu793Pro ENST00000455089.5:c.2378T>C 7:g.55191762T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879564 1879564 1770066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1135423 1135423 1047987 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1168010 1168010 1080252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594603 1594603 1515571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592880 1592880 1513806 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592880 1592880 1513806 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 ESO-963 1890976 1780345 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV51799199 COSM1251020 133209185 c.1639G>A p.V547I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Reported in another cancer sample as somatic 23525077 surgery fresh/frozen primary 75 ENSP00000415559.1:p.Val547Ile ENST00000455089.5:c.1639G>A 7:g.55165331G>A EGFR ENST00000275493.6 3633 3236 1196964 1196964 1108859 lung NS NS NS other neoplasm NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983701 1983701 1869937 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226885 2226885 2094620 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1075002 1075002 990256 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 55 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983776 1983776 1870012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891202 1891202 1780571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668525 1668525 1581818 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1456552 1456552 1380527 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983825 1983825 1870061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895155 1895155 1783847 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879488 1879488 1769990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1660210 1660210 1574483 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21768327 surgery - NOS primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1837415 1837415 1731614 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23242437 NS NS 63 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2680771 2680771 2540044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1631937 1631937 1548807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042902 1042902 959243 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302274 1302274 1213325 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064719 2064719 1944796 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899327 899327 816939 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625562 2625562 2485974 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 51 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891334 1891334 1780703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990906 1990906 1876241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899317 899317 816929 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1734960 1734960 1640904 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 33 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1197366 1197366 1109261 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1074948 1074948 990202 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 4 2570195 2431492 skin face NS NS adnexal_tumour sebaceous_carcinoma NS NS n COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 53 ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00355T00355 2857331 2712631 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924512 924512 841285 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924512 924512 841285 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879570 1879570 1770072 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 921172 921172 838131 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense het + - Reported in another cancer sample as somatic 16002952 surgery-fixed primary 42 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1059476 1059476 975546 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 17429313 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2148503 2148503 2017633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2047823 2047823 1928095 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899345 899345 816957 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1197352 1197352 1109247 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009161 2009161 1891895 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1734967 1734967 1640911 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1882511 1882511 1772647 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767827 COSM1235378 99401095 c.2560A>T p.T854S Substitution - Missense hom 38 7:55191809-55191809 + - PATHOGENIC .98595 Reported in another cancer sample as somatic 23486275 NS NS 54 ENSP00000275493.2:p.Thr854Ser ENST00000275493.6:c.2560A>T 7:g.55191809A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891283 1891283 1780652 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1107244 1107244 1021156 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5326 915962 833361 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51823220 COSM13179 132558313 c.1945C>T p.P649S Substitution - Missense 38 7:55173939-55173939 + - PATHOGENIC .97389 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000395243.3:p.Pro649Ser ENST00000454757.6:c.1945C>T 7:g.55173939C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2027344 2027344 1909412 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 40 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2027344 2027344 1909412 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 40 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891276 1891276 1780645 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-160-tumor 2819059 2675358 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0127-01 1910170 1798461 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766389 COSM43067 132572320 c.739G>T p.V247L Substitution - Missense het 38 7:55154137-55154137 + - PATHOGENIC .98997 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 67 ENSP00000395243.3:p.Val247Leu ENST00000454757.6:c.739G>T 7:g.55154137G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098859 1098859 1013451 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 965389 965389 881673 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16382114 surgery-fixed NS 57 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KYSE-450 1339910 1250286 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 20443891 cell-line NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-042-tumor 2818992 2675291 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1523014 1523014 1445386 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 72 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1523012 1523012 1445384 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 71 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879561 1879561 1770063 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879487 1879487 1769989 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2730696 2730696 2589468 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 132550443 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + Yes Reported in another cancer sample as somatic 29673089 surgery-fixed primary 54 ENSP00000395243.3:p.Leu702Pro ENST00000454757.6:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1876986 1876986 1767548 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 946827 946827 863350 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891249 1891249 1780618 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891247 1891247 1780616 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1965639 1965639 1852132 lung left_lower_lobe NS NS carcinoma large_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23774386 surgery - NOS metastasis 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1965639 1965639 1852132 lung left_lower_lobe NS NS carcinoma large_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23774386 surgery - NOS metastasis 72 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00331T00331 2857371 2712671 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2659797 2659797 2519955 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51782636 COSM85961 99375603 c.2518G>A p.A840T Substitution - Missense 38 7:55191767-55191767 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Ala840Thr ENST00000275493.6:c.2518G>A 7:g.55191767G>A EGFR ENST00000275493.6 3633 3236 2226915 2226915 2094650 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777782 COSM6227 99381636 c.2504A>T p.H835L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.His835Leu ENST00000275493.6:c.2504A>T 7:g.55191753A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 946826 946826 863349 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 MG-168-tumor 2819062 2675361 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00240T00240 2857369 2712669 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 MG-083-tumor 2819016 2675315 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166429 1166429 1078743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773206 COSM28603 132560955 c.2158G>A p.V720M Substitution - Missense hom 38 7:55181302-55181302 + - PATHOGENIC .97963 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 70 ENSP00000395243.3:p.Val720Met ENST00000454757.6:c.2158G>A 7:g.55181302G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594591 1594591 1515559 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51837705 COSM29577 132563747 c.2428G>A p.D810N Substitution - Missense 38 7:55191812-55191812 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000395243.3:p.Asp810Asn ENST00000454757.6:c.2428G>A 7:g.55191812G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895125 1895125 1783817 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879538 1879538 1770040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CT75 1063219 979264 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 65 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1484304 1484304 1407930 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51773392 COSM20892 132592219 c.2276A>G p.E759G Substitution - Missense 38 7:55181420-55181420 + - PATHOGENIC .9793 Reported in another cancer sample as somatic 21266046 surgery-fixed primary 68 ENSP00000395243.3:p.Glu759Gly ENST00000454757.6:c.2276A>G 7:g.55181420A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2076198 2076198 1955011 lung right_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 24396447 bronchoalveolar lavage fluid NS 73 ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098877 1098877 1013469 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1777412 1777412 1681415 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966255 1966255 1852748 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23800712 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2562092 2562092 2423488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 BL-16-G44694 2905057 2759313 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1983748 1983748 1869984 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1246717 1246717 1158396 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1983709 1983709 1869945 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345518 2345518 2210190 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148503 2148503 2017633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1730103 1730103 1636074 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 22753836 fine needle aspirate NS ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879235 1879235 1769790 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51787507 COSM13188 133213942 c.2146G>A p.D716N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 23468066 surgery-fixed NS 55 ENSP00000415559.1:p.Asp716Asn ENST00000455089.5:c.2146G>A 7:g.55174818G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625579 2625579 2485991 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 74 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1998651 1998651 1883723 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51779524 COSM18425 132552477 c.2021G>A p.G674D Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .97987 Reported in another cancer sample as somatic 23945392 surgery - NOS primary 62 ENSP00000395243.3:p.Gly674Asp ENST00000454757.6:c.2021G>A 7:g.55174015G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1998651 1998651 1883723 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 132551897 c.2447T>G p.L816R Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .98181 Reported in another cancer sample as somatic 23945392 surgery - NOS primary 62 ENSP00000395243.3:p.Leu816Arg ENST00000454757.6:c.2447T>G 7:g.55191831T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-104-tumor 2819030 2675329 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891213 1891213 1780582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668435 1668435 1581728 lung left_upper_lobe NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22526156 surgery-fixed primary 18 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1435967 1435967 1345246 lung right_lower_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery-fixed primary 47 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2579570 2579570 2440907 NS NS NS NS malignant_melanoma NS NS NS n COSV51787507 COSM13188 132557864 c.2146G>A p.D716N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000395243.3:p.Asp716Asn ENST00000454757.6:c.2146G>A 7:g.55174818G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231321 1231321 1143111 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 V17 1179742 1091704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 50 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1135425 1135425 1047989 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1931648 1931648 1818938 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BC1-2 2824184 2680011 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51787208 COSM327142 132549881 c.3217G>A p.A1073T Substitution - Missense 38 7:55205336-55205336 + - NEUTRAL .10522 Reported in another cancer sample as somatic 31867841 circulating tumour recurrent 54 ENSP00000395243.3:p.Ala1073Thr ENST00000454757.6:c.3217G>A 7:g.55205336G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625594 2625594 2486006 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 52 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1113004 1113004 1026511 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 18302229 surgery - NOS NS 64 ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AX-A0J0-01 1783376 1687375 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51770777 COSM28286 133220429 c.2359C>T p.R787C Substitution - Missense het 38 7:55191743-55191743 + - PATHOGENIC .95135 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 47 ENSP00000415559.1:p.Arg787Cys ENST00000455089.5:c.2359C>T 7:g.55191743C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879485 1879485 1769987 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980074 1980074 1866317 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 59 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1-87 946049 862575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602814 1602814 1522150 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1200917 1200917 1112807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983704 1983704 1869940 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429329 1429329 1338780 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1541741 1541741 1464045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21469767 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009153 2009153 1891887 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450921 1450921 1375064 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 81 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602801 1602801 1522137 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1931642 1931642 1818932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429292 1429292 1338743 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042910 1042910 959251 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103633 1103633 1017885 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1876989 1876989 1767551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895160 1895160 1783852 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1200918 1200918 1112808 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1000056 1000056 917279 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1310479 1310479 1221424 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479954 1479954 1403614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891269 1891269 1780638 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983823 1983823 1870059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990905 1990905 1876240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1113005 1113005 1026511 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 18302229 surgery - NOS NS 64 ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1451632 1451632 1375775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 20855820 surgery - NOS NS ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592882 1592882 1513808 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895065 1895065 1783757 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226871 2226871 2094606 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879509 1879509 1770011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895122 1895122 1783814 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GCT135 2490762 2353411 genital_tract extragonadal central_nervous_system NS germ_cell_tumour embryonal_carcinoma NS NS n COSV51769863 COSM1090888 132554400 c.2089G>A p.V697I Substitution - Missense 38 7:55174761-55174761 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 26956871 surgery fresh/frozen metastasis ENSP00000395243.3:p.Val697Ile ENST00000454757.6:c.2089G>A 7:g.55174761G>A EGFR ENST00000275493.6 3633 3236 1937588 1937588 1824522 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0219-01 1910209 1798500 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 67 ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-121-tumor 2819042 2675341 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0002PT00018T00018 2857363 2712663 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879520 1879520 1770022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-228-tumor 2819103 2675402 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2855910 2855910 2711313 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV104368998 COSM9232920 132563469 c.751C>T p.P251S Substitution - Missense 38 7:55154149-55154149 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 32269842 surgery-fixed NS 58 ENSP00000395243.3:p.Pro251Ser ENST00000454757.6:c.751C>T 7:g.55154149C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 12 1077311 992565 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 MG-066-tumor 2819004 2675303 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1036644 1036644 953401 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM22423 178380012 c.? p.P733S Substitution - Missense + - Reported in another cancer sample as somatic 17201173 NS NS ENSP00000275493.2:p.Pro733Ser EGFR ENST00000275493.6 3633 3236 1429297 1429297 1338748 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2772830 2772830 2631012 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 29594878 surgery - NOS recurrent 89 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897799 897799 815421 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602818 1602818 1522154 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1751714 1751714 1656530 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899309 899309 816921 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-076-tumor 2819012 2675311 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2579268 2579268 2440605 NS NS NS NS malignant_melanoma NS NS NS n COSV51778029 COSM6268 99381060 c.2257C>T p.P753S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000275493.2:p.Pro753Ser ENST00000275493.6:c.2257C>T 7:g.55174794C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453496 1453496 1377529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2076208 2076208 1955020 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24406864 surgery-fixed primary 27 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 16 1433981 1343396 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1074947 1074947 990201 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 45 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089597 1089597 1004544 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-49-4490-01 1780137 1684136 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 45 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077334 1077334 992588 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1575146 1575146 1496587 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924336 924336 841111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001552 1001552 918775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15851406 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2078360 2078360 1957079 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24314215 pleural effusion NS 49 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1751706 1751706 1656522 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668459 1668459 1581752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009151 2009151 1891885 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1047000 1047000 963231 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895083 1895083 1783775 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1295828 1295828 1206900 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19640859 fine needle aspirate primary 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879528 1879528 1770030 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098870 1098870 1013462 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1549837 1549837 1471942 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914810 914810 832259 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1202555 1202555 1114441 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983783 1983783 1870019 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983702 1983702 1869938 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983771 1983771 1870007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914806 914806 832255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983721 1983721 1869957 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372583 2372583 2235376 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1451209 1451209 1375352 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103632 1103632 1017884 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 55 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110459 1110459 1024337 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103751 1103751 1018003 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1876993 1876993 1767555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875348 1875348 1765931 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899314 899314 816926 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593023 1593023 1513949 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983836 1983836 1870072 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1931644 1931644 1818934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1310476 1310476 1221421 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1625792 1625792 1543016 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2616332 2616332 2476818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26118982 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1456553 1456553 1380528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668531 1668531 1581824 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1094003 1094003 1008705 urinary_tract bladder NS NS carcinoma NS NS NS n COSV51769451 COSM26036 132598302 c.2471A>G p.Y824C Substitution - Missense 38 7:55191855-55191855 + - PATHOGENIC .986 Reported in another cancer sample as somatic 17707060 surgery fresh/frozen NS ENSP00000395243.3:p.Tyr824Cys ENST00000454757.6:c.2471A>G 7:g.55191855A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103804 1103804 1018056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18271876 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453488 1453488 1377521 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239171 2239171 2106703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 50 ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239171 2239171 2106703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767386 COSM18423 132564484 c.2365G>T p.V789L Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .9903 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 50 ENSP00000395243.3:p.Val789Leu ENST00000454757.6:c.2365G>T 7:g.55191749G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239171 2239171 2106703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 50 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1751708 1751708 1656524 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1110739 1110739 1024617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 18325048 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1110739 1110739 1024617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 18325048 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1770543 1770543 1674783 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1602795 1602795 1522131 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659761 2659761 2519919 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51802272 COSM13425 133221191 c.2170G>A p.V724M Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .98024 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Val724Met ENST00000455089.5:c.2170G>A 7:g.55181314G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S001005 1027699 944675 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675370 2675370 2534644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51794784 COSM13182 132548944 c.2068G>A p.G690S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000395243.3:p.Gly690Ser ENST00000454757.6:c.2068G>A 7:g.55174740G>A EGFR ENST00000275493.6 3633 3236 V80 1179749 1091711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 79 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453413 1453413 1377446 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1067075 1067075 983055 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602800 1602800 1522136 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983733 1983733 1869969 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983727 1983727 1869963 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983830 1983830 1870066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1456576 1456576 1380551 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983777 1983777 1870013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899336 899336 816948 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862090 2862090 2717292 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1567520 1567520 1489152 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21949883 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1479940 1479940 1403600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1032022 1032022 948813 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17060940 pleural effusion NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1107248 1107248 1021160 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1694969 1694969 1603189 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 49 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891336 1891336 1780705 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895141 1895141 1783833 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891262 1891262 1780631 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602799 1602799 1522135 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 G36 1063244 979289 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 618-1503-04TD 1921502 1808820 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51797215 COSM145360 133214261 c.832G>A p.V278I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Reported in another cancer sample as somatic 340 blood NS ENSP00000415559.1:p.Val278Ile ENST00000455089.5:c.832G>A 7:g.55155907G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1434026 1434026 1343441 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1789323 1789323 1692727 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1196037 1196037 1107932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19272767 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1592995 1592995 1513921 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469491 1469491 1393230 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770577 1770577 1674817 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667709 1667709 1581002 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2479708 2479708 2342454 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1154308 1154308 1066644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18957054 surgery-fixed NS 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2439552 2439552 2302392 lung NS NS NS carcinoma invasive_mucinous_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24119562 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372765 2372765 2235558 pleura NS NS NS mesothelioma NS NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24569782 surgery-fixed NS 72 ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1980068 1980068 1866311 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 72 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1576781 1576781 1498222 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 77 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2432377 2432377 2295280 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 26473643 surgery fresh/frozen metastasis 53 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 899356 899356 816968 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51780206 COSM12373 99380273 c.2159C>T p.S720F Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .9768 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Ser720Phe ENST00000275493.6:c.2159C>T 7:g.55174018C>T EGFR ENST00000275493.6 3633 3236 1694973 1694973 1603193 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862714 2862714 2717877 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 99396060 c.2281G>T p.D761Y Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99554 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Asp761Tyr ENST00000275493.6:c.2281G>T 7:g.55174818G>T EGFR ENST00000275493.6 3633 3236 2862714 2862714 2717877 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2148622 2148622 2017752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1081597 1081597 996816 lung left_upper_lobe NS NS other hyperplasia NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17618248 surgery-fixed NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083350 1083350 998515 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17596643 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2156993 2156993 2025968 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2209395 2209395 2077628 lung NS NS NS carcinoma signet_ring_cell_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25007143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2432459 2432459 2295360 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25798276 NS NS 80 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345047 2345047 2209719 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1879428 1879428 1769933 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23464964 surgery-fixed NS 70 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2069641 2069641 1949046 skin NS NS NS malignant_melanoma acral_lentiginous NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22437319 surgery-fixed primary 53 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345051 2345051 2209723 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2307231 2307231 2172468 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25496960 surgery - NOS NS 48 ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2733218 2733218 2591971 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 42 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 1980066 1980066 1866309 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 56 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1522946 1522946 1445318 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 56 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1891336 1891336 1780705 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2637650 2637650 2498023 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 65 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2637689 2637689 2498062 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770552 1770552 1674792 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226152 2226152 2093887 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106537 2106537 1984400 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1661838 1661838 1575451 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22487432 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1697982 1697982 1606100 salivary_gland NS NS NS carcinoma acinic_cell_carcinoma NS NS n COSV51773049 COSM22943 99376120 c.2543C>T p.P848L Substitution - Missense het 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 22694907 surgery-fixed NS ENSP00000275493.2:p.Pro848Leu ENST00000275493.6:c.2543C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 1879235 1879235 1769790 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51787507 COSM13188 99385457 c.2281G>A p.D761N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 23468066 surgery-fixed NS 55 ENSP00000275493.2:p.Asp761Asn ENST00000275493.6:c.2281G>A 7:g.55174818G>A EGFR ENST00000275493.6 3633 3236 2046650 2046650 1926944 lung NS NS NS carcinoma NS NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1887437 1887437 1777109 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1886122 1886122 1776007 lung left_upper_lobe NS NS carcinoma large_cell_neuroendocrine_carcinoma mixed NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23518631 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1668435 1668435 1581728 lung left_upper_lobe NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22526156 surgery-fixed primary 18 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1484355 1484355 1407981 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSM24273 178386680 c.? p.R748K Substitution - Missense + - Reported in another cancer sample as somatic 21266046 surgery-fixed primary 53 ENSP00000275493.2:p.Arg748Lys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098861 1098861 1013453 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1043134 1043134 959475 upper_aerodigestive_tract tonsil NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51793896 COSM22954 99389719 c.2324G>A p.C775Y Substitution - Missense 38 7:55181333-55181333 + - PATHOGENIC .97278 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 53 ENSP00000275493.2:p.Cys775Tyr ENST00000275493.6:c.2324G>A 7:g.55181333G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862721 2862721 2717884 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1507380 1507380 1430249 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51794784 COSM13182 132548944 c.2068G>A p.G690S Substitution - Missense hom 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 21487925 NS NS ENSP00000395243.3:p.Gly690Ser ENST00000454757.6:c.2068G>A 7:g.55174740G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924292 924292 841067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780206 COSM12373 132553376 c.2024C>T p.S675F Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .9768 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Ser675Phe ENST00000454757.6:c.2024C>T 7:g.55174018C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 B00278 2910543 2764405 ovary NS NS NS carcinoma clear_cell_carcinoma NS NS n COSV51769863 COSM1090888 132554400 c.2089G>A p.V697I Substitution - Missense 38 7:55174761-55174761 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 33947352 surgery-fixed NS ENSP00000395243.3:p.Val697Ile ENST00000454757.6:c.2089G>A 7:g.55174761G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 21 2626696 2487087 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 27322425 surgery-fixed metastasis ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 2226869 2226869 2094604 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1201378 1201378 1113268 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 19357847 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 897804 897804 815426 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264193 2264193 2131177 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0008349-T01-IM5 2724478 2583299 haematopoietic_and_lymphoid_tissue lymph_node NS NS lymphoid_neoplasm angioimmunoblastic_T_cell_lymphoma NS NS n COSV51806667 COSM6987130 99400907 c.1939G>A p.A647T Substitution - Missense het 38 7:55173002-55173002 + - PATHOGENIC .99609 Reported in another cancer sample as somatic 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala647Thr ENST00000275493.6:c.1939G>A 7:g.55173002G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 109588 2812897 2669311 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 45 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AB-2878-03 1650370 1565157 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV51771306 COSM1318972 132562649 c.1778C>T p.T593M Substitution - Missense het 38 7:55171207-55171207 + - NEUTRAL .03249 Reported in another cancer sample as somatic 377 blood-bone marrow NS 47 ENSP00000395243.3:p.Thr593Met ENST00000454757.6:c.1778C>T 7:g.55171207C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-17-G42045 2905103 2759359 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983774 1983774 1870010 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1498652 1498652 1421530 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21315472 surgery - NOS metastasis 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2864413 2864413 2719570 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26199566 surgery-fixed NS 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264261 2264261 2131245 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-AS-3778-01 1779806 1683805 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51831642 COSM1496684 99388394 c.988G>A p.E330K Substitution - Missense 38 7:55155928-55155928 + - PATHOGENIC .94538 Reported in another cancer sample as somatic 416 fresh/frozen - NOS primary 35 ENSP00000275493.2:p.Glu330Lys ENST00000275493.6:c.988G>A 7:g.55155928G>A EGFR ENST00000275493.6 3633 3236 1531502 1531502 1453862 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 21681119 surgery - NOS NS ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1694962 1694962 1603182 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226913 2226913 2094648 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51845318 COSM214350 132553232 c.2467G>A p.E823K Substitution - Missense 38 7:55191851-55191851 + - PATHOGENIC .98896 Variant of unknown origin 24891042 NS NS ENSP00000395243.3:p.Glu823Lys ENST00000454757.6:c.2467G>A 7:g.55191851G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1694975 1694975 1603195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064726 2064726 1944803 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897817 897817 815439 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1202554 1202554 1114440 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-205-tumor 2819087 2675386 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1077346 1077346 992600 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891268 1891268 1780637 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226864 2226864 2094599 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-67-3770-01 1780199 1684198 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1197365 1197365 1109260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1047002 1047002 963233 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983754 1983754 1869990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862710 2862710 2717873 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895126 1895126 1783818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895115 1895115 1783807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1067062 1067062 983042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 20 1433985 1343400 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895068 1895068 1783760 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2372597 2372597 2235390 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302283 1302283 1213334 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1631945 1631945 1548815 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1089142 1089142 1004096 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891285 1891285 1780654 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 6 1077305 992559 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51815927 COSM24971 99392587 c.2513T>C p.L838P Substitution - Missense 38 7:55191762-55191762 + - PATHOGENIC .97813 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu838Pro ENST00000275493.6:c.2513T>C 7:g.55191762T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042855 1042855 959196 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51780730 COSM22940 132551401 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Arg731His ENST00000454757.6:c.2192G>A 7:g.55181336G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450923 1450923 1375066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980062 1980062 1866305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 76 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891166 1891166 1780535 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479927 1479927 1403587 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1738902 1738902 1644733 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891232 1891232 1780601 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914815 914815 832264 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592984 1592984 1513910 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1000048 1000048 917271 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1931646 1931646 1818936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 11-18 946048 862574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1135415 1135415 1047979 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594555 1594555 1515523 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2057513 2057513 1937720 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24255770 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1549827 1549827 1471932 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924332 924332 841107 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891280 1891280 1780649 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897834 897834 815456 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602798 1602798 1522134 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089595 1089595 1004542 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631954 1631954 1548824 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 HCC149 2776336 2634472 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29681454 NS NS 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895124 1895124 1783816 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2046176 2046176 1926471 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1964224 1964224 1850759 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1790517 1790517 1693496 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766268 COSM13183 99377562 c.2225T>C p.V742A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Reported in another cancer sample as somatic 16152581 fixed - NOS NS ENSP00000275493.2:p.Val742Ala ENST00000275493.6:c.2225T>C 7:g.55174762T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592884 1592884 1513810 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2281 1188091 1099990 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19235531 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1884155 1884155 1774042 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983723 1983723 1869959 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594597 1594597 1515565 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2662907 2662907 2523029 kidney NS NS NS Wilms_tumour NS NS NS n COSV51778029 COSM6268 99381060 c.2257C>T p.P753S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 28326956 surgery-fixed NS ENSP00000275493.2:p.Pro753Ser ENST00000275493.6:c.2257C>T 7:g.55174794C>T EGFR ENST00000275493.6 3633 3236 2064724 2064724 1944801 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875793 1875793 1766376 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226886 2226886 2094621 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450942 1450942 1375085 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 65 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1479932 1479932 1403592 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1103803 1103803 1018055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1075003 1075003 990257 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 55 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1594598 1594598 1515566 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1434020 1434020 1343435 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1005358 1005358 922570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429298 1429298 1338749 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983720 1983720 1869956 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862727 2862727 2717890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862732 2862732 2717895 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1202551 1202551 1114437 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990916 1990916 1876251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1434016 1434016 1343431 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 24 1077323 992577 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1038992 1038992 955569 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983722 1983722 1869958 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895065 1895065 1783757 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895080 1895080 1783772 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875340 1875340 1765923 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1573770 1573770 1495239 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21982684 surgery fresh/frozen primary 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1931637 1931637 1818927 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602595 1602595 1521931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22082647 surgery-fixed primary 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1627729 1627729 1544641 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891193 1891193 1780562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983769 1983769 1870005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 896919 896919 814542 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15329413 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899324 899324 816936 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089601 1089601 1004548 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 G22 1063236 979281 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2402526 2402526 2265382 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345458 2345458 2210130 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1602797 1602797 1522133 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1135555 1135555 1048119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 18676761 NS NS 55 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2148503 2148503 2017633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1965911 1965911 1852404 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096237 2096237 1974301 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1468082 1468082 1391928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 75 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 CL97 1790396 1693405 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 23024022 cell-line NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081900 2081900 1960322 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1776852 1776852 1680897 lung left_upper_lobe NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 23037472 surgery - NOS metastasis 56 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1445180 1445180 1369423 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 20682976 surgery - NOS metastasis 54 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081903 2081903 1960325 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2637638 2637638 2498011 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 58 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422842 2422842 2285764 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862787 2862787 2717950 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767280 COSM133183 133220067 c.2007G>C p.K669N Substitution - Missense 38 7:55174001-55174001 + - PATHOGENIC .89357 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Lys669Asn ENST00000455089.5:c.2007G>C 7:g.55174001G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S002024 1027695 944671 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51785554 COSM21688 133203816 c.836G>T p.R279L Substitution - Missense het 38 7:55155911-55155911 + - PATHOGENIC .97287 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Arg279Leu ENST00000455089.5:c.836G>T 7:g.55155911G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1168007 1168007 1080249 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1648536 1648536 1563491 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 132550443 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000395243.3:p.Leu702Pro ENST00000454757.6:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983725 1983725 1869961 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1705344 1705344 1613328 lung right_middle_lobe NS NS carcinoma large_cell_carcinoma NS NS n COSV51789625 COSM13197 132549922 c.2455G>A p.A819T Substitution - Missense 38 7:55191839-55191839 + - PATHOGENIC .9615 Reported in another cancer sample as somatic 22722798 NS NS 59 ENSP00000395243.3:p.Ala819Thr ENST00000454757.6:c.2455G>A 7:g.55191839G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1734961 1734961 1640905 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LUAD_E01319 1765124 1669444 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51801471 COSM53105 99379999 c.2492G>A p.R831H Substitution - Missense 38 7:55191741-55191741 + - PATHOGENIC .96289 Reported in another cancer sample as somatic 22980975 surgery - NOS primary ENSP00000275493.2:p.Arg831His ENST00000275493.6:c.2492G>A 7:g.55191741G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897811 897811 815433 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 G6 1063231 979276 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 84 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 G6 1063231 979276 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 84 ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CCK81 2301965 2167248 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51765999 COSM3266658 132575022 c.3071A>G p.Y1024C Substitution - Missense het 38 7:55202560-55202560 + - PATHOGENIC .97752 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000395243.3:p.Tyr1024Cys ENST00000454757.6:c.3071A>G 7:g.55202560A>G EGFR ENST00000275493.6 3633 3236 2264435 2264435 2131419 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2595765 2595765 2456641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2778777 2778777 2636831 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 29066915 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1734162 1734162 1640111 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 22843912 NS primary ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875363 1875363 1765946 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103766 1103766 1018018 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 59 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659797 2659797 2519955 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51782636 COSM85961 133203897 c.2383G>A p.A795T Substitution - Missense 38 7:55191767-55191767 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Ala795Thr ENST00000455089.5:c.2383G>A 7:g.55191767G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00332T00332 2857343 2712643 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 G22 1063236 979281 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 75 ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479923 1479923 1403583 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895151 1895151 1783843 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1746673 1746673 1651649 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 50 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1996942 1996942 1882151 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1435992 1435992 1345271 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 20439191 surgery fresh/frozen NS 85 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481237 1481237 1404866 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618662 1618662 1537414 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 88 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2205986 2205986 2074219 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1434452 1434452 1343810 eye conjunctiva NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51768262 COSM26445 132550179 c.2165C>T p.A722V Substitution - Missense 38 7:55181309-55181309 + - PATHOGENIC .97799 Reported in another cancer sample as somatic 20498858 fixed - NOS NS ENSP00000395243.3:p.Ala722Val ENST00000454757.6:c.2165C>T 7:g.55181309C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239179 2239179 2106711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 70 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 273T 910551 828036 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766928 COSM12718 99378527 c.2180A>G p.Y727C Substitution - Missense het 38 7:55174039-55174039 + - PATHOGENIC .97626 Reported in another cancer sample as somatic 15735034 cell-line NS ENSP00000275493.2:p.Tyr727Cys ENST00000275493.6:c.2180A>G 7:g.55174039A>G EGFR ENST00000275493.6 3633 3236 1879483 1879483 1769985 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2081901 2081901 1960323 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422837 2422837 2285759 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618751 1618751 1537503 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 74 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-099-tumor 2819026 2675325 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226877 2226877 2094612 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879559 1879559 1770061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1891323 1891323 1780692 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1980072 1980072 1866315 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 71 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1103803 1103803 1018055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1235138 1235138 1146924 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 53 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891331 1891331 1780700 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891331 1891331 1780700 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 3791 915999 833398 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51784752 COSM13199 132549074 c.2483G>A p.G828E Substitution - Missense 38 7:55191867-55191867 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000395243.3:p.Gly828Glu ENST00000454757.6:c.2483G>A 7:g.55191867G>A EGFR ENST00000275493.6 3633 3236 1493342 1493342 1416332 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637075 1637075 1553123 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914919 1914919 1802921 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838691 1838691 1732792 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587265 1587265 1508436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174319 1174319 1086338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042904 1042904 959245 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1434018 1434018 1343433 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1838695 1838695 1732796 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1036699 1036699 953456 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17106442 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844346 1844346 1737380 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667697 1667697 1580990 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838561 1838561 1732662 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046006 2046006 1926301 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026250 2026250 1908339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1135555 1135555 1048119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18676761 NS NS 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1284669 1284669 1195964 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16467085 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106545 2106545 1984408 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027805 2027805 1909708 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1052977 1052977 969048 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17410005 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1445170 1445170 1369413 lung right NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20592359 NS NS 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226188 2226188 2093923 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214558 2214558 2082682 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045986 2045986 1926281 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914916 1914916 1802918 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770553 1770553 1674793 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844337 1844337 1737371 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083818 1083818 998983 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095903 2095903 1973967 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838727 1838727 1732828 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2439553 2439553 2302393 lung NS NS NS carcinoma invasive_mucinous_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24119562 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2864418 2864418 2719574 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26199566 surgery-fixed NS 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1081590 1081590 996809 lung right_upper_lobe NS NS other hyperplasia NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17618248 surgery-fixed NS 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026218 2026218 1908307 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425768 2425768 2288689 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174304 1174304 1086323 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2562086 2562086 2423482 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1235141 1235141 1146927 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19589612 surgery - NOS recurrent 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290961 2290961 2157026 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2032065 2032065 1913536 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24103528 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1856348 1856348 1748901 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770696 1770696 1674936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937567 1937567 1824501 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345378 2345378 2210050 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592888 1592888 1513814 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098816 1098816 1013408 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098816 1098816 1013408 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2734339 2734339 2593066 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 29731638 circulating tumour recurrent 52 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1517053 1517053 1439647 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 49 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226765 2226765 2094500 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1881683 1881683 1771834 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23391413 NS metastasis ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914803 914803 832252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-18-K35709 2905399 2759655 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51847987 COSM4384128 132558569 c.2731G>A p.D911N Substitution - Missense 38 7:55200333-55200333 + - PATHOGENIC .99504 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Asp911Asn ENST00000454757.6:c.2731G>A 7:g.55200333G>A EGFR ENST00000275493.6 3633 3236 1246666 1246666 1158345 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770522 1770522 1674762 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1498645 1498645 1421523 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21315472 surgery - NOS primary 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770707 1770707 1674947 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345437 2345437 2210109 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081900 2081900 1960322 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1081605 1081605 996824 lung left_upper_lobe NS NS other hyperplasia NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17618248 surgery-fixed NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1672459 1672459 1585513 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21729655 surgery-fixed metastasis 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591025 1591025 1512141 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983148 983148 898866 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105814 2105814 1983852 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 23 1596833 1517546 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20093389 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885173 1885173 1775060 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469174 1469174 1392913 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21130517 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014310 1014310 931484 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770570 1770570 1674810 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547765 1547765 1469887 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed primary 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51834362 COSM6503269 99385331 c.2153T>A p.L718Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000275493.2:p.Leu718Gln ENST00000275493.6:c.2153T>A 7:g.55174012T>A EGFR ENST00000275493.6 3633 3236 1637189 1637189 1553237 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1445180 1445180 1369423 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20682976 surgery - NOS metastasis 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937533 1937533 1824467 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2485112 2485112 2347812 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20630828 NS primary 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214552 2214552 2082676 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887423 1887423 1777095 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2156955 2156955 2025930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS 85 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205973 2205973 2074206 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264435 2264435 2131419 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081903 2081903 1960325 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874664 1874664 1765255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218530 2218530 2086541 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766493 COSM6493937 133216269 c.2254T>A p.C752S Substitution - Missense het 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2254T>A 7:g.55181398T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51832101 COSM6493933 133219834 c.2239C>T p.L747F Substitution - Missense het 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000415559.1:p.Leu747Phe ENST00000455089.5:c.2239C>T 7:g.55181383C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-16-G30012 2905599 2759855 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51815598 COSM6471954 132564281 c.1190G>T p.S397I Substitution - Missense 38 7:55160165-55160165 + - NEUTRAL .44157 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Ser397Ile ENST00000454757.6:c.1190G>T 7:g.55160165G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098862 1098862 1013454 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1456581 1456581 1380556 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-266-tumor 2819117 2675416 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 983104 983104 898822 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842972 1842972 1736220 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2595765 2595765 2456641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240657 2240657 2108188 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591026 1591026 1512142 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838693 1838693 1732794 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1052966 1052966 969037 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17410005 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095895 2095895 1973959 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230480 1230480 1142294 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203112 2203112 2071370 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278200 1278200 1189498 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081932 2081932 1960354 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24440279 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731712 1731712 1637678 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22809298 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000158 2000158 1885056 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493366 1493366 1416356 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422842 2422842 2285764 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141309 1141309 1053757 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203077 2203077 2071335 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083797 1083797 998962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173402 1173402 1085486 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045974 2045974 1926269 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 29 1596839 1517552 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20093389 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875690 1875690 1766273 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083354 1083354 998519 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17596643 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474457 2474457 2337226 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279053 1279053 1190349 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed metastasis 61 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1047910 1047910 964139 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17335935 pleural effusion recurrent 83 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1973999 1973999 1860241 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1882612 1882612 1772747 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23493804 pleural effusion metastasis 72 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009155 2009155 1891889 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098864 1098864 1013456 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 G719S-GR 2772831 2631013 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 29594878 pleural effusion recurrent 89 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 G719S-GR 2772831 2631013 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 29594878 pleural effusion recurrent 89 ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2757124 2757124 2615767 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 132549057 c.2183A>T p.H728L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 29858019 surgery - NOS NS 50 ENSP00000395243.3:p.His728Leu ENST00000454757.6:c.2183A>T 7:g.55181327A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2757124 2757124 2615767 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 29858019 surgery - NOS NS 50 ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 911627 911627 829110 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1469816 1469816 1393555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2153115 2153115 2022125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032251 2032251 1913722 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1882236 1882236 1772387 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23392229 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1526365 1526365 1448733 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21623281 pleural effusion recurrent 61 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2637618 2637618 2497991 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 56 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027720 2027720 1909623 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 G37 1063245 979290 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 70 ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891175 1891175 1780544 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0002PT00013T00013 2857370 2712670 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV99291226 COSM7552389 132573051 c.989C>T p.A330V Substitution - Missense 38 7:55156650-55156650 + - PATHOGENIC .98971 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Ala330Val ENST00000454757.6:c.989C>T 7:g.55156650C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098875 1098875 1013467 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2026152 2026152 1908241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766168 COSM1716256 99378822 c.2228C>T p.A743V Substitution - Missense het 38 7:55174765-55174765 + - PATHOGENIC .99382 Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Ala743Val ENST00000275493.6:c.2228C>T 7:g.55174765C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2538747 2538747 2400385 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51785733 COSM28575 133235090 c.2515G>A p.E839K Substitution - Missense 38 7:55192790-55192790 + - PATHOGENIC .9655 Reported in another cancer sample as somatic 27425854 surgery - NOS secondary 59 ENSP00000415559.1:p.Glu839Lys ENST00000455089.5:c.2515G>A 7:g.55192790G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 23 2570184 2431481 skin forearm NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51767182 COSM27110 133210338 c.2221G>A p.V741M Substitution - Missense 38 7:55181365-55181365 + - PATHOGENIC .97319 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 67 ENSP00000415559.1:p.Val741Met ENST00000455089.5:c.2221G>A 7:g.55181365G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891171 1891171 1780540 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891294 1891294 1780663 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1738931 1738931 1644762 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924339 924339 841114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891240 1891240 1780609 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2729141 2729141 2587952 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 29368620 fixed - NOS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2096278 2096278 1974342 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2476909 2476909 2339678 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2345537 2345537 2210209 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777372 1777372 1681375 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1746673 1746673 1651649 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 50 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996945 1996945 1882154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240663 2240663 2108194 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 47 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547821 1547821 1469943 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 pleural effusion primary 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996942 1996942 1882151 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120938 1120938 1034094 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1673288 1673288 1586342 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22225786 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346548 2346548 2211211 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777319 1777319 1681322 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290954 2290954 2157019 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1076401 1076401 991655 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17607119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047751 2047751 1928023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141292 1141292 1053740 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667705 1667705 1580998 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2729130 2729130 2587941 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29368620 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475404 1475404 1399103 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246722 1246722 1158401 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345364 2345364 2210036 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476865 2476865 2339634 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1789317 1789317 1692721 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895112 1895112 1783804 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1517071 1517071 1439665 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2035481 2035481 1916843 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24034463 pleural effusion recurrent 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110466 1110466 1024344 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-F00134 1765150 1669470 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 87 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450932 1450932 1375075 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 56 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1981027 1981027 1867263 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 11-18-GEF10-1 1731375 1637341 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22815900 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042901 1042901 959242 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668523 1668523 1581816 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067041 1067041 983021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924446 924446 841221 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 16198442 surgery - NOS recurrent 58 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891215 1891215 1780584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226171 2226171 2093906 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547779 1547779 1469901 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed primary 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2479680 2479680 2342431 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26923333 NS NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008787 2008787 1891521 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637240 1637240 1553288 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838723 1838723 1732824 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476909 2476909 2339678 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983159 983159 898877 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770566 1770566 1674806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965810 1965810 1852303 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1489669 1489669 1412827 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21155184 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475465 1475465 1399164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264194 2264194 2131178 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095987 2095987 1974051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076969 2076969 1955718 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed metastasis 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960170 1960170 1846810 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842981 1842981 1736229 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965908 1965908 1852401 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1355113 1355113 1265208 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777320 1777320 1681323 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965835 1965835 1852328 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014263 1014263 931437 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914893 1914893 1802895 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1162986 1162986 1075309 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18992959 NS recurrent 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469348 1469348 1393087 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1856653 1856653 1749205 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23334261 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1052963 1052963 969034 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17410005 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618785 1618785 1537537 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637113 1637113 1553161 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960176 1960176 1846816 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081901 2081901 1960323 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676437 1676437 1589205 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638739 1638739 1554738 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264291 2264291 2131275 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937570 1937570 1824504 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921922 1921922 1809240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734169 1734169 1640118 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22843912 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535042 1535042 1457377 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1752330 1752330 1657141 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22912354 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937554 1937554 1824488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246670 1246670 1158349 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174331 1174331 1086350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1707035 1707035 1614941 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22695392 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329244 1329244 1239729 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214527 2214527 2082651 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1107251 1107251 1021163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982785 982785 898504 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302272 1302272 1213323 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1881375 1881375 1771526 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983778 1983778 1870014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593013 1593013 1513939 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162207 1162207 1074539 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980081 1980081 1866324 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 65 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895150 1895150 1783842 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239179 2239179 2106711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SJHYPO052 2301072 2166353 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 132554159 c.1144C>T p.R382C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Reported in another cancer sample as somatic 638 NS NS ENSP00000395243.3:p.Arg382Cys ENST00000454757.6:c.1144C>T 7:g.55157734C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891239 1891239 1780608 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0157-01 1910184 1798475 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 63 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1770611 1770611 1674851 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1516777 1516777 1439371 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21575212 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105822 2105822 1983860 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1135346 1135346 1047912 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17591931 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937513 1937513 1824447 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2157004 2157004 2025979 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014322 1014322 931496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422837 2422837 2285759 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1312885 1312885 1223794 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19884861 blood-bone marrow NS 44 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237702 1237702 1149449 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1526364 1526364 1448732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21623281 surgery - NOS primary 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1196961 1196961 1108856 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774696 1774696 1678920 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS metastasis 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618751 1618751 1537503 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000232 2000232 1885130 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095918 2095918 1973982 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173388 1173388 1085472 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680566 2680566 2539839 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542352 1542352 1464655 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1599067 1599067 1519554 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22091430 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1031899 1031899 948690 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17085664 NS recurrent ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2616331 2616331 2476817 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26118982 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 20 2570182 2431479 skin ear NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51778659 COSM14070 133202857 c.2453G>A p.G818D Substitution - Missense 38 7:55191837-55191837 + - PATHOGENIC .92688 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 70 ENSP00000415559.1:p.Gly818Asp ENST00000455089.5:c.2453G>A 7:g.55191837G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302295 1302295 1213346 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1074939 1074939 990193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879494 1879494 1769996 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-NYU608 1765135 1669455 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51772147 COSM375343 132564558 c.1799C>G p.S600C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 64 ENSP00000395243.3:p.Ser600Cys ENST00000454757.6:c.1799C>G 7:g.55172997C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891178 1891178 1780547 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1991296 1991296 1876631 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 11 1433976 1343391 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 81 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 G1 1063227 979272 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 65 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891205 1891205 1780574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1500178 1500178 1423057 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631950 1631950 1548820 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983750 1983750 1869986 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891204 1891204 1780573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1197354 1197354 1109249 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983835 1983835 1870071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983826 1983826 1870062 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631960 1631960 1548830 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1038998 1038998 955575 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1714999 1714999 1622578 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22710815 surgery-fixed metastasis 71 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-112-tumor 2819035 2675334 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 24 1596834 1517547 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20093389 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120926 1120926 1034082 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937560 1937560 1824494 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290955 2290955 2157020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937545 1937545 1824479 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 916972 916972 834353 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16052537 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591031 1591031 1512147 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214525 2214525 2082649 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2559403 2559403 2420827 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24158231 surgery fresh/frozen NS 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029027 2029027 1910909 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937509 1937509 1824443 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637081 1637081 1553129 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1732074 1732074 1638040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21622214 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493327 1493327 1416317 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965851 1965851 1852344 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729971 1729971 1635942 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240543 2240543 2108074 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25227801 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205979 2205979 2074212 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179660 1179660 1091622 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1672475 1672475 1585529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21729655 surgery-fixed metastasis 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240670 2240670 2108201 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148591 2148591 2017721 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064722 2064722 1944799 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668535 1668535 1581828 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879544 1879544 1770046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1575159 1575159 1496600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1444759 1444759 1369002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1047910 1047910 964139 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17335935 pleural effusion recurrent 83 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240549 2240549 2108080 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25227801 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264335 2264335 2131319 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141315 1141315 1053763 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1112975 1112975 1026486 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448997 surgery-fixed NS 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921954 1921954 1809272 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777352 1777352 1681355 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862638 2862638 2717801 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28677170 surgery-fixed primary 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2151312 2151312 2020356 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24758910 NS NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000167 2000167 1885065 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1526365 1526365 1448733 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21623281 pleural effusion recurrent 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1052969 1052969 969040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17410005 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1036633 1036633 953390 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17201173 pleural effusion NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777393 1777393 1681396 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479084 1479084 1402777 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014256 1014256 931430 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986165 1986165 1872401 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983117 983117 898835 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862069 2862069 2717276 lung NS NS NS carcinoma fetal_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25851923 surgery-fixed NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770584 1770584 1674824 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1892634 1892634 1781886 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23566546 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118433 2118433 1992668 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106557 2106557 1984420 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000069 2000069 1884967 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676440 1676440 1589208 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1661850 1661850 1575463 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22487432 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1113264 1113264 1026764 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18449007 surgery-fixed NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279088 1279088 1190384 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed primary 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1047976 1047976 964204 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17337084 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095990 2095990 1974054 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637259 1637259 1553307 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264111 2264111 2131095 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025386 2025386 1907475 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637250 1637250 1553298 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203104 2203104 2071362 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777275 1777275 1681278 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1434757 1434757 1344115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20813423 surgery - NOS primary 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983124 983124 898842 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983107 983107 898825 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-201-tumor 2819084 2675383 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2000174 2000174 1885072 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228278 2228278 2096007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095997 2095997 1974061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1590994 1590994 1512110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770545 1770545 1674785 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921952 1921952 1809270 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983145 983145 898863 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430054 1430054 1339472 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637162 1637162 1553210 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014242 1014242 931416 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fresh/frozen - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336844 1336844 1247229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214549 2214549 2082673 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479094 1479094 1402787 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1246489 1246489 1158168 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2214579 2214579 2082703 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1635453 1635453 1551958 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22333554 surgery-fixed primary 62 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1310471 1310471 1221416 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897848 897848 815470 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914816 914816 832265 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765252 COSM13009 132568674 c.1991A>G p.E664G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000395243.3:p.Glu664Gly ENST00000454757.6:c.1991A>G 7:g.55173985A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914816 914816 832265 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914813 914813 832262 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089137 1089137 1004091 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BC1-4 2824186 2680012 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51787208 COSM327142 132549881 c.3217G>A p.A1073T Substitution - Missense 38 7:55205336-55205336 + - NEUTRAL .10522 Reported in another cancer sample as somatic 31867841 circulating tumour recurrent 54 ENSP00000395243.3:p.Ala1073Thr ENST00000454757.6:c.3217G>A 7:g.55205336G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-0219-01 1910209 1798500 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 67 ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 G1 1063227 979272 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 65 ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-125-tumor 2819044 2675343 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 109618 2812909 2669323 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 52 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0002PT00013T00013 2857370 2712670 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-027-tumor 2818987 2675286 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00221T00221 2857376 2712676 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2035480 2035480 1916842 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24034463 surgery - NOS NS 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897848 897848 815470 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1648525 1648525 1563480 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1648525 1648525 1563480 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1469947 1469947 1393686 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51774667 COSM53194 132555352 c.2062C>T p.P688S Substitution - Missense het 38 7:55174734-55174734 + - PATHOGENIC .99806 Reported in another cancer sample as somatic 20873989 surgery fresh/frozen primary ENSP00000395243.3:p.Pro688Ser ENST00000454757.6:c.2062C>T 7:g.55174734C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980075 1980075 1866318 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 54 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2372592 2372592 2235385 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 NCI-H1975 1047098 963329 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17332333 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1107250 1107250 1021162 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2009159 2009159 1891893 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1162204 1162204 1074536 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 914805 914805 832254 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent 52 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1594592 1594592 1515560 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1083995 1083995 999160 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17785547 surgery fresh/frozen primary 83 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1876987 1876987 1767549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924341 924341 841116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1668473 1668473 1581766 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2479707 2479707 2342453 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897847 897847 815469 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891211 1891211 1780580 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899321 899321 816933 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2659808 2659808 2519966 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1451206 1451206 1375349 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1077335 1077335 992589 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2057511 2057511 1937718 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24255770 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2625549 2625549 2485961 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302288 1302288 1213339 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1202562 1202562 1114448 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875385 1875385 1765968 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1103769 1103769 1018021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592972 1592972 1513898 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768262 COSM26445 133205089 c.2165C>T p.A722V Substitution - Missense 38 7:55181309-55181309 + - PATHOGENIC .97799 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Ala722Val ENST00000455089.5:c.2165C>T 7:g.55181309C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2538973 2538973 2400568 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 132550443 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 27499993 circulating tumour NS 61 ENSP00000395243.3:p.Leu702Pro ENST00000454757.6:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429330 1429330 1338781 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51806057 COSM41603 132580496 c.1999T>C p.F667L Substitution - Missense 38 7:55173993-55173993 + - PATHOGENIC .92149 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Phe667Leu ENST00000454757.6:c.1999T>C 7:g.55173993T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895165 1895165 1783857 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602806 1602806 1522142 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239181 2239181 2106713 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 50 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239181 2239181 2106713 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 50 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2734489 2734489 2593198 pancreas NS NS NS other solid_pseudopapillary_neoplasm NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 29695402 surgery-fixed primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166447 1166447 1078761 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 77 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1738959 1738959 1644790 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914814 914814 832263 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51803429 COSM7002279 132557298 c.1145G>A p.R382H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000395243.3:p.Arg382His ENST00000454757.6:c.1145G>A 7:g.55157735G>A EGFR ENST00000275493.6 3633 3236 1855971 1855971 1748524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2046175 2046175 1926470 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2402473 2402473 2265329 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 75 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2733535 2733535 2592288 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29704676 circulating tumour recurrent 36 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1024775 1024775 941752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 surgery fresh/frozen recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1522943 1522943 1445315 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 63 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778772 2778772 2636826 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891320 1891320 1780689 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879235 1879235 1769790 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23468066 surgery-fixed NS 55 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226916 2226916 2094651 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777782 COSM6227 133210005 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.His790Leu ENST00000455089.5:c.2369A>T 7:g.55191753A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239188 2239188 2106720 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777782 COSM6227 133210005 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 25130612 fine needle aspirate NS 75 ENSP00000415559.1:p.His790Leu ENST00000455089.5:c.2369A>T 7:g.55191753A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1074944 1074944 990198 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226901 2226901 2094636 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895133 1895133 1783825 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098815 1098815 1013407 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765252 COSM13009 132568674 c.1991A>G p.E664G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Glu664Gly ENST00000454757.6:c.1991A>G 7:g.55173985A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098815 1098815 1013407 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924511 924511 841284 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2637626 2637626 2497999 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 83 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027822 2027822 1909725 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1547786 1547786 1469908 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 37 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1965910 1965910 1852403 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422821 2422821 2285743 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2667608 2667608 2527270 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28874593 surgery - NOS metastasis 57 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2078354 2078354 1957073 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24314215 fine needle aspirate NS 57 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895089 1895089 1783781 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891251 1891251 1780620 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226898 2226898 2094633 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1295350 1295350 1206429 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19884551 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1816950 1816950 1716118 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879574 1879574 1770076 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1576784 1576784 1498225 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 surgery - NOS primary 60 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1980080 1980080 1866323 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 43 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879575 1879575 1770077 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 MG-014-tumor 2818981 2675280 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2680524 2680524 2539797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 33 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665704 2665704 2525413 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28978102 pleural effusion recurrent 72 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2665704 2665704 2525413 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 pleural effusion recurrent 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2696524 2696524 2555428 central_nervous_system middle_frontal_gyrus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28201779 surgery fresh/frozen NS 56 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2026152 2026152 1908241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766168 COSM1716256 133206916 c.2093C>T p.A698V Substitution - Missense het 38 7:55174765-55174765 + - PATHOGENIC .99382 Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000415559.1:p.Ala698Val ENST00000455089.5:c.2093C>T 7:g.55174765C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891319 1891319 1780688 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00354T00354 2857354 2712654 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1945218 1945218 1832128 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51767379 COSM85894 132557468 c.2392G>A p.V798I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 23295441 surgery-fixed NS ENSP00000395243.3:p.Val798Ile ENST00000454757.6:c.2392G>A 7:g.55191776G>A EGFR ENST00000275493.6 3633 3236 1246739 1246739 1158418 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2096254 2096254 1974318 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2078490 2078490 1957209 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1024775 1024775 941752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 17020982 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667711 1667711 1581004 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921891 1921891 1809209 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777279 1777279 1681282 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2245053 2245053 2112329 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2028996 2028996 1910878 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777232 1777232 1681235 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914932 1914932 1802934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705492 1705492 1613398 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174320 1174320 1086339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214551 2214551 2082675 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729978 1729978 1635949 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014316 1014316 931490 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965918 1965918 1852411 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879512 1879512 1770014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891334 1891334 1780703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103638 1103638 1017890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 62 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895072 1895072 1783764 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914817 914817 832266 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2555800 2555800 2417237 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26599269 surgery - NOS NS 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777335 1777335 1681338 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842962 1842962 1736210 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1882521 1882521 1772656 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23486266 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076943 2076943 1955692 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed NS 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402522 2402522 2265378 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937590 1937590 1824524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141301 1141301 1053749 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045975 2045975 1926270 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469350 1469350 1393089 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1029251 1029251 946122 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16921488 pleural effusion NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148605 2148605 2017735 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237667 1237667 1149414 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014121 1014121 931295 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459502 1459502 1383445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 511 1716347 1623909 lung right_upper_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22733594 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983136 983136 898854 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2823672 2823672 2679524 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31798692 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045955 2045955 1926250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983109 983109 898827 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1837420 1837420 1731619 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23242437 NS NS 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777299 1777299 1681302 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279040 1279040 1190336 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed primary 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2865242 2865242 2720372 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29413048 surgery-fixed primary 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179668 1179668 1091630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921927 1921927 1809245 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770674 1770674 1674914 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844347 1844347 1737381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264258 2264258 2131242 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095922 2095922 1973986 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2141445 2141445 2010663 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24636848 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237669 1237669 1149416 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1980992 1980992 1867234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23842453 surgery fresh/frozen primary 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656131 1656131 1570788 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21311943 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237674 1237674 1149421 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226182 2226182 2093917 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027789 2027789 1909692 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239169 2239169 2106701 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 133206317 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 48 ENSP00000415559.1:p.Arg731His ENST00000455089.5:c.2192G>A 7:g.55181336G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1278399 1278399 1189695 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19596957 cerebrospinal fluid metastasis 51 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1530684 1530684 1453056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21227397 surgery-fixed NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980078 1980078 1866321 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 60 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778768 2778768 2636822 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983761 1983761 1869997 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2214524 2214524 2082648 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637088 1637088 1553136 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421201 2421201 2284123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430058 1430058 1339476 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1465887 1465887 1389734 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1512593 1512593 1435277 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21508367 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422784 2422784 2285706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937559 1937559 1824493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2033332 2033332 1914803 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24137465 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046013 2046013 1926308 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264112 2264112 2131096 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986162 1986162 1872398 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637260 1637260 1553308 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1489672 1489672 1412830 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21155184 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096055 2096055 1974119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2156959 2156959 2025934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS 80 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246680 1246680 1158359 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2151452 2151452 2020487 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24742923 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2245054 2245054 2112330 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000258 2000258 1885156 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965884 1965884 1852377 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469460 1469460 1393199 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770572 1770572 1674812 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246704 1246704 1158383 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618645 1618645 1537397 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346520 2346520 2211183 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239175 2239175 2106707 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51777782 COSM6227 133210005 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 49 ENSP00000415559.1:p.His790Leu ENST00000455089.5:c.2369A>T 7:g.55191753A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982785 982785 898504 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778594 2778594 2636648 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51784752 COSM13199 132549074 c.2483G>A p.G828E Substitution - Missense 38 7:55191867-55191867 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000395243.3:p.Gly828Glu ENST00000454757.6:c.2483G>A 7:g.55191867G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1078226 1078226 993476 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 17626639 surgery-fixed metastasis ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1891316 1891316 1780685 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2078480 2078480 1957199 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163053 2163053 2031637 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451763 1451763 1375812 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20615575 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1839254 1839254 1733355 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51776282 COSM1168015 133202278 c.2123C>T p.P708L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Reported in another cancer sample as somatic 23244191 surgery-fixed primary ENSP00000415559.1:p.Pro708Leu ENST00000455089.5:c.2123C>T 7:g.55174795C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2161697 2161697 2030304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24813888 surgery - NOS recurrent 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891295 1891295 1780664 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1102406 1102406 1016658 lung right_upper_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18208799 surgery-fixed primary 47 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-67-3772-01 1780202 1684201 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 82 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453490 1453490 1377523 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891306 1891306 1780675 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-78-7147-01 1914054 1802336 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 67 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875356 1875356 1765939 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-02-0003-01 1910122 1798413 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51809225 COSM35825 132574944 c.1724G>A p.C575Y Substitution - Missense het 38 7:55165416-55165416 + - PATHOGENIC .99893 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 50 ENSP00000395243.3:p.Cys575Tyr ENST00000454757.6:c.1724G>A 7:g.55165416G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098818 1098818 1013410 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51851382 COSM26437 132561971 c.2432T>C p.F811S Substitution - Missense 38 7:55191816-55191816 + - PATHOGENIC .97798 Variant of unknown origin 18176089 surgery fresh/frozen primary 50 ENSP00000395243.3:p.Phe811Ser ENST00000454757.6:c.2432T>C 7:g.55191816T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136893 1136893 1049457 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862076 2862076 2717282 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 32122695 surgery - NOS metastasis 62 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1074946 1074946 990200 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983779 1983779 1870015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2686011 2686011 2545046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1489661 1489661 1412819 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21155184 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2064710 2064710 1944787 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2805811 2805811 2662548 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 31348837 surgery - NOS NS ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862076 2862076 2717282 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 32122695 surgery - NOS metastasis 62 ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-147-tumor 2819052 2675351 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2345444 2345444 2210116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179657 1179657 1091619 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194736 1194736 1106631 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067045 1067045 983025 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1075906 1075906 991160 lung NS NS NS other hyperplasia NS NS n COSV51772923 COSM21984 132565801 c.2146G>T p.D716Y Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99554 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000395243.3:p.Asp716Tyr ENST00000454757.6:c.2146G>T 7:g.55174818G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1075906 1075906 991160 lung NS NS NS other hyperplasia NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732886 2732886 2591639 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779091 COSM2155593 132560457 c.953C>T p.T318I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 50 ENSP00000395243.3:p.Thr318Ile ENST00000454757.6:c.953C>T 7:g.55156614C>T EGFR ENST00000275493.6 3633 3236 2047815 2047815 1928087 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226870 2226870 2094605 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2106540 2106540 1984403 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226890 2226890 2094625 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 E7 1303893 1214944 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20036793 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887430 1887430 1777102 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1668670 1668670 1581962 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22523351 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986150 1986150 1872386 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1135348 1135348 1047914 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17591931 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777348 1777348 1681351 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120924 1120924 1034080 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1097467 1097467 1012131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 18090579 NS NS 45 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2651873 2651873 2512013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 27257132 surgery - NOS recurrent 71 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891322 1891322 1780691 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891328 1891328 1780697 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879569 1879569 1770071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 HCC827CLR 1604992 1524306 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 22133747 cell-line NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1876999 1876999 1767561 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668551 1668551 1581844 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000205-T01-IM3 2714809 2573630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875376 1875376 1765959 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1618879 1618879 1537631 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 22209037 surgery-fixed primary 68 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2785991 2785991 2643451 large_intestine colon right NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 27586204 NS NS 91 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1235127 1235127 1146913 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 55 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450922 1450922 1375065 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 52 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1083994 1083994 999159 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17785547 surgery fresh/frozen primary 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899333 899333 816945 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983785 1983785 1870021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891194 1891194 1780563 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1627726 1627726 1544638 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983759 1983759 1869995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372594 2372594 2235387 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593009 1593009 1513935 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899337 899337 816949 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450940 1450940 1375083 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1627723 1627723 1544635 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2113071 2113071 1987332 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51787507 COSM13188 133213942 c.2146G>A p.D716N Substitution - Missense het 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 24595526 surgery-fixed NS ENSP00000415559.1:p.Asp716Asn ENST00000455089.5:c.2146G>A 7:g.55174818G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077344 1077344 992598 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891182 1891182 1780551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 109590 2812898 2669312 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 56 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1714998 1714998 1622577 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22710815 surgery-fixed primary 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891218 1891218 1780587 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891286 1891286 1780655 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983719 1983719 1869955 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098857 1098857 1013449 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077331 1077331 992585 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042912 1042912 959253 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732921 2732921 2591674 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 49 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 1974002 1974002 1860244 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773712 COSM13433 99385694 c.2318A>G p.H773R Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98391 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000275493.2:p.His773Arg ENST00000275493.6:c.2318A>G 7:g.55181327A>G EGFR ENST00000275493.6 3633 3236 1591050 1591050 1512166 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174321 1174321 1086340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264249 2264249 2131233 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246737 1246737 1158416 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2864414 2864414 2719570 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26199566 surgery-fixed NS 55 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983757 1983757 1869993 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895121 1895121 1783813 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2479686 2479686 2342434 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26923333 NS NS 43 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098874 1098874 1013466 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043859 1043859 960200 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067077 1067077 983057 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1054393 1054393 970464 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479946 1479946 1403606 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136861 1136861 1049425 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2878966 2878966 2733481 oesophagus NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51813913 COSM6023901 132555174 c.344A>C p.N115T Substitution - Missense 38 7:55143408-55143408 + - PATHOGENIC .92454 Reported in another cancer sample as somatic 33115932 surgery-fixed NS 68 ENSP00000395243.3:p.Asn115Thr ENST00000454757.6:c.344A>C 7:g.55143408A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162207 1162207 1074539 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766880 COSM28516 133219865 c.2269G>T p.V757F Substitution - Missense 38 7:55181413-55181413 + - PATHOGENIC .89385 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000415559.1:p.Val757Phe ENST00000455089.5:c.2269G>T 7:g.55181413G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879513 1879513 1770015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980064 1980064 1866307 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 67 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983782 1983782 1870018 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875380 1875380 1765963 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983824 1983824 1870060 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990900 1990900 1876235 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1715002 1715002 1622581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22710815 surgery-fixed metastasis 69 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-66-2742-01 1782475 1686474 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 418 fresh/frozen - NOS primary 70 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042859 1042859 959200 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042859 1042859 959200 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1882510 1882510 1772646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51803731 COSM28604 99377260 c.2506C>T p.R836C Substitution - Missense het 38 7:55191755-55191755 + - PATHOGENIC .95213 Reported in another cancer sample as somatic 23486275 pleural effusion metastasis 81 ENSP00000275493.2:p.Arg836Cys ENST00000275493.6:c.2506C>T 7:g.55191755C>T EGFR ENST00000275493.6 3633 3236 1774665 1774665 1678889 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS primary 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535025 1535025 1457360 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2659801 2659801 2519959 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1937557 1937557 1824491 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983149 983149 898867 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009140 2009140 1891874 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067063 1067063 983043 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453429 1453429 1377462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1697230 1697230 1605348 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21616658 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043124 1043124 959465 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51789261 COSM12986 133218176 c.2294G>A p.G765D Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98244 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 54 ENSP00000415559.1:p.Gly765Asp ENST00000455089.5:c.2294G>A 7:g.55181438G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891316 1891316 1780685 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 45 2786467 2643890 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51849884 COSM13192 133211467 c.2293G>A p.G765S Substitution - Missense 38 7:55181437-55181437 + - PATHOGENIC .98229 Reported in another cancer sample as somatic 30115035 surgery-fixed NS ENSP00000415559.1:p.Gly765Ser ENST00000455089.5:c.2293G>A 7:g.55181437G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891210 1891210 1780579 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2095940 2095940 1974004 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1856651 1856651 1749203 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23334261 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891168 1891168 1780537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899347 899347 816959 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594553 1594553 1515521 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51793030 COSM133566 132578206 c.2372G>A p.R791H Substitution - Missense 38 7:55191756-55191756 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000395243.3:p.Arg791His ENST00000454757.6:c.2372G>A 7:g.55191756G>A EGFR ENST00000275493.6 3633 3236 2226765 2226765 2094500 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1517053 1517053 1439647 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 49 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2148649 2148649 2017779 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1729754 1729754 1635725 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22805266 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2644144 2644144 2504431 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2156949 2156949 2025924 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS 70 ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 OX-CO-2_R3_Cetux 2841378 2696927 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 133218349 c.1256C>T p.S419L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000415559.1:p.Ser419Leu ENST00000455089.5:c.1256C>T 7:g.55160231C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625554 2625554 2485966 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862724 2862724 2717887 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226766 2226766 2094501 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 19 2773123 2631300 skin shoulder NS NS other seborrhoeic_keratosis acanthotic NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23739246 surgery fresh/frozen NS 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2011184 2011184 1893822 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM28574 178384302 c.? p.P848L Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Pro848Leu EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2701162 2701162 2560066 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51822289 COSM42977 132570284 c.315G>T p.Q105H Substitution - Missense het 38 7:55143379-55143379 + - PATHOGENIC .90579 Reported in another cancer sample as somatic 28581676 surgery-fixed NS 41 ENSP00000395243.3:p.Gln105His ENST00000454757.6:c.315G>T 7:g.55143379G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1876996 1876996 1767558 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-NYU704 1765133 1669453 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 55 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592879 1592879 1513805 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592879 1592879 1513805 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862118 2862118 2717320 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875373 1875373 1765956 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CT81 1063221 979266 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 39 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895152 1895152 1783844 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1751709 1751709 1656525 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077345 1077345 992599 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1777338 1777338 1681341 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 B00426 2910515 2764377 ovary NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51792433 COSM6966446 99410412 c.1762G>A p.G588S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Reported in another cancer sample as somatic 33947352 surgery-fixed NS ENSP00000275493.2:p.Gly588Ser ENST00000275493.6:c.1762G>A 7:g.55165319G>A EGFR ENST00000275493.6 3633 3236 TCGA-AP-A0LM-01 1783352 1687351 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51797307 COSM1090871 99399215 c.1310C>A p.S437Y Substitution - Missense het 38 7:55160150-55160150 + - PATHOGENIC .98943 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 33 ENSP00000275493.2:p.Ser437Tyr ENST00000275493.6:c.1310C>A 7:g.55160150C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD_E01319 1765124 1669444 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51801471 COSM53105 133208181 c.2357G>A p.R786H Substitution - Missense 38 7:55191741-55191741 + - PATHOGENIC .96289 Reported in another cancer sample as somatic 22980975 surgery - NOS primary ENSP00000415559.1:p.Arg786His ENST00000455089.5:c.2357G>A 7:g.55191741G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895097 1895097 1783789 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-06-0154-01 1910182 1798473 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense hom 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 55 ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DH402C 2762552 2620811 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51780730 COSM22940 132551401 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 29615459 NS primary 65 ENSP00000395243.3:p.Arg731His ENST00000454757.6:c.2192G>A 7:g.55181336G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675682 2675682 2534956 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 29100434 surgery - NOS recurrent ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891272 1891272 1780641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891264 1891264 1780633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1549839 1549839 1471944 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 77 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895140 1895140 1783832 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891258 1891258 1780627 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862722 2862722 2717885 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 911622 911622 829105 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899322 899322 816934 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1789321 1789321 1692725 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064712 2064712 1944789 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043855 1043855 960196 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897805 897805 815427 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875792 1875792 1766375 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920163 920163 837243 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659803 2659803 2519961 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1075912 1075912 991166 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891217 1891217 1780586 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2770729 2770729 2628930 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25403583 surgery-fixed recurrent 43 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891308 1891308 1780677 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2345111 2345111 2209783 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2025443 2025443 1907532 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372584 2372584 2235377 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1789322 1789322 1692726 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226907 2226907 2094642 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51834362 COSM6503269 133213822 c.2018T>A p.L673Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000415559.1:p.Leu673Gln ENST00000455089.5:c.2018T>A 7:g.55174012T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1661392 1661392 1575007 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 22483783 surgery-fixed NS 61 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879529 1879529 1770031 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1576795 1576795 1498236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 surgery - NOS metastasis 86 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2205960 2205960 2074193 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469367 1469367 1393106 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637269 1637269 1553317 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675161 2675161 2534435 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766268 COSM13183 133205606 c.2090T>C p.V697A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Reported in another cancer sample as somatic 29075127 surgery fresh/frozen NS ENSP00000415559.1:p.Val697Ala ENST00000455089.5:c.2090T>C 7:g.55174762T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450928 1450928 1375071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 50 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450857 1450857 1375000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 81 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592979 1592979 1513905 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51779734 COSM133203 132559785 c.2270T>C p.V757A Substitution - Missense 38 7:55181414-55181414 + - PATHOGENIC .95834 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Val757Ala ENST00000454757.6:c.2270T>C 7:g.55181414T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1992095 1992095 1877412 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow NS 53 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879496 1879496 1769998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2345094 2345094 2209766 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2865243 2865243 2720373 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 29413048 surgery-fixed primary 49 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2163062 2163062 2031646 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1964330 1964330 1850865 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1996951 1996951 1882160 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 60 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 NPC0001PT00227T00227 2857348 2712648 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 MG-111-tumor 2819034 2675333 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 899358 899358 816970 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1078227 1078227 993477 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17626639 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2757127 2757127 2615769 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 99375713 c.2318A>T p.H773L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 29858019 ascites recurrent 50 ENSP00000275493.2:p.His773Leu ENST00000275493.6:c.2318A>T 7:g.55181327A>T EGFR ENST00000275493.6 3633 3236 2757127 2757127 2615769 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 29858019 ascites recurrent 50 ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 1551559 1551559 1473664 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879551 1879551 1770053 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659762 2659762 2519920 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2035481 2035481 1916843 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 24034463 pleural effusion recurrent 74 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980070 1980070 1866313 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 64 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 H820 2776289 2634425 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29681454 NS NS 53 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891325 1891325 1780694 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1992088 1992088 1877405 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 50 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0002PT00039T00039 2857325 2712625 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875353 1875353 1765936 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1310470 1310470 1221415 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1113004 1113004 1026511 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 18302229 surgery - NOS NS 64 ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 1066987 1066987 982967 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17504988 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 4 2570195 2431492 skin face NS NS adnexal_tumour sebaceous_carcinoma NS NS n COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 53 ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-78-7155-01 1914061 1802343 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51802828 COSM6178056 132618143 c.1161A>T p.Q387H Substitution - Missense 38 7:55157751-55157751 + - PATHOGENIC .9647 Variant of unknown origin 417 fresh/frozen - NOS primary 68 ENSP00000395243.3:p.Gln387His ENST00000454757.6:c.1161A>T 7:g.55157751A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1052730 1052730 968801 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17368623 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1881389 1881389 1771540 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 132549057 c.2183A>T p.H728L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000395243.3:p.His728Leu ENST00000454757.6:c.2183A>T 7:g.55181327A>T EGFR ENST00000275493.6 3633 3236 1453489 1453489 1377522 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1318769 1318769 1229667 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773049 COSM22943 99376120 c.2543C>T p.P848L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 19955396 surgery fresh/frozen NS ENSP00000275493.2:p.Pro848Leu ENST00000275493.6:c.2543C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 109596 2812901 2669315 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 72 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1451632 1451632 1375775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 20855820 surgery - NOS NS ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 1113005 1113005 1026511 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 18302229 surgery - NOS NS 64 ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00414T00414 2857361 2712661 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 MG-075-tumor 2819011 2675310 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479954 1479954 1403614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778770 2778770 2636824 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1179108 1179108 1091070 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19185949 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1039708 1039708 956285 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 17051834 pleural effusion primary 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 899330 899330 816942 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1542353 1542353 1464656 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2906656 2906656 2760907 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29616327 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895077 1895077 1783769 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1592972 1592972 1513898 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768262 COSM26445 99377063 c.2300C>T p.A767V Substitution - Missense 38 7:55181309-55181309 + - PATHOGENIC .97799 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Ala767Val ENST00000275493.6:c.2300C>T 7:g.55181309C>T EGFR ENST00000275493.6 3633 3236 2733218 2733218 2591971 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 42 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 2680469 2680469 2539742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 63 ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1108050 1108050 1021953 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 17973572 pleural effusion recurrent 74 ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1108050 1108050 1021953 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17973572 pleural effusion recurrent 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064725 2064725 1944802 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879540 1879540 1770042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1618860 1618860 1537612 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2239174 2239174 2106706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1921953 1921953 1809271 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549160 2549160 2410615 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425752 2425752 2288673 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027347 2027347 1909415 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 52 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2733569 2733569 2592322 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSM34167 178379046 c.? p.G598V Substitution - Missense + - Reported in another cancer sample as somatic 29683790 surgery - NOS primary ENSP00000275493.2:p.Gly598Val EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879525 1879525 1770027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879543 1879543 1770045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879571 1879571 1770073 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LU1868 1775135 1679359 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22948846 xenograft NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LU1868 1775135 1679359 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 22948846 xenograft NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005362 1005362 922574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 77 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897802 897802 815424 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 907081 907081 824593 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1166447 1166447 1078761 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 77 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2734489 2734489 2593198 pancreas NS NS NS other solid_pseudopapillary_neoplasm NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 29695402 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1789319 1789319 1692723 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879535 1879535 1770037 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 082-02-1TD 1921512 1808830 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51769737 COSM145359 132583523 c.3367G>A p.D1123N Substitution - Missense 38 7:55205486-55205486 + - PATHOGENIC .97139 Reported in another cancer sample as somatic 340 blood NS ENSP00000395243.3:p.Asp1123Asn ENST00000454757.6:c.3367G>A 7:g.55205486G>A EGFR ENST00000275493.6 3633 3236 1637072 1637072 1553120 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535033 1535033 1457368 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667655 1667655 1580948 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1774662 1774662 1678886 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22993320 surgery - NOS metastasis 58 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2426846 2426846 2289767 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2684446 2684446 2543484 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29128427 circulating tumour recurrent 44 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1052727 1052727 968798 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 133205309 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 17368623 NS NS ENSP00000415559.1:p.Leu702Pro ENST00000455089.5:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR ENST00000275493.6 3633 3236 2249999 2249999 2117258 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24646139 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2153171 2153171 2022181 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027728 2027728 1909631 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746678 1746678 1651654 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525666 2525666 2387858 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1981028 1981028 1867264 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1542180 1542180 1464483 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422838 2422838 2285760 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 DCR10 1690659 1598936 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 99388924 c.1476C>A p.S492R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000275493.2:p.Ser492Arg ENST00000275493.6:c.1476C>A 7:g.55160316C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2476320 2476320 2339088 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 26870223 fine needle aspirate metastasis 48 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2476320 2476320 2339088 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 26870223 fine needle aspirate metastasis 48 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-16-A36234 2905681 2759937 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 2659761 2659761 2519919 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51802272 COSM13425 99394305 c.2305G>A p.V769M Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .98024 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Val769Met ENST00000275493.6:c.2305G>A 7:g.55181314G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895146 1895146 1783838 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1075001 1075001 990255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 50 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897807 897807 815429 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1981021 1981021 1867257 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875795 1875795 1766378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-RT-S01856 1765145 1669465 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875367 1875367 1765950 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593010 1593010 1513936 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1000049 1000049 917272 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1575154 1575154 1496595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924347 924347 841122 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594602 1594602 1515570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990898 1990898 1876233 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602817 1602817 1522153 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594600 1594600 1515568 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983711 1983711 1869947 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895132 1895132 1783824 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1884152 1884152 1774039 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166445 1166445 1078759 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 81 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983818 1983818 1870054 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110454 1110454 1024332 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110453 1110453 1024331 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895078 1895078 1783770 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098863 1098863 1013455 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-NYU1210 1765146 1669466 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659811 2659811 2519969 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2372778 2372778 2235571 pleura NS NS NS mesothelioma NS NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24569782 surgery-fixed NS 85 ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1996923 1996923 1882132 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 65 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2595753 2595753 2456629 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2426885 2426885 2289806 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM26133 178385018 c.? p.L747S Substitution - Missense + - Reported in another cancer sample as somatic 25561229 NS NS ENSP00000275493.2:p.Leu747Ser EGFR ENST00000275493.6 3633 3236 1777318 1777318 1681321 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1673286 1673286 1586340 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22225786 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000256 2000256 1885154 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045985 2045985 1926280 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046001 2046001 1926296 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770575 1770575 1674815 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770559 1770559 1674799 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587286 1587286 1508457 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346478 2346478 2211141 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096053 2096053 1974117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547822 1547822 1469944 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2426846 2426846 2289767 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469442 1469442 1393181 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983760 1983760 1869996 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064716 2064716 1944793 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897812 897812 815434 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2029022 2029022 1910904 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2822206 2822206 2678066 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26373574 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1081604 1081604 996823 lung left_upper_lobe NS NS other hyperplasia NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17618248 surgery-fixed NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770644 1770644 1674884 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842979 1842979 1736227 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345541 2345541 2210213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637697 2637697 2498070 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965893 1965893 1852386 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1673290 1673290 1586344 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22225786 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469432 1469432 1393171 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 899345 899345 816957 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264295 2264295 2131279 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096043 2096043 1974107 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046171 2046171 1926466 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2345847 2345847 2210519 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1534804 1534804 1457141 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21684626 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625554 2625554 2485966 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1434022 1434022 1343437 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899353 899353 816965 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2214725 2214725 2082849 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25047674 surgery - NOS NS 52 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891271 1891271 1780640 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1102407 1102407 1016659 lung right_upper_lobe NS NS other hyperplasia NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18208799 surgery-fixed NS 47 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2579398 2579398 2440735 NS NS NS NS malignant_melanoma NS NS NS n COSV51788796 COSM4680390 133226922 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000415559.1:p.Arg98Gln ENST00000455089.5:c.293G>A 7:g.55143357G>A EGFR ENST00000275493.6 3633 3236 1237693 1237693 1149440 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680687 2680687 2539960 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2684446 2684446 2543484 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29128427 circulating tumour recurrent 44 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076975 2076975 1955724 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095955 2095955 1974019 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680479 2680479 2539752 lung NS NS NS carcinoma invasive_mucinous_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed metastasis 45 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083470 2083470 1961753 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481316 surgery - NOS primary 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2372822 2372822 2235615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25904052 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638755 1638755 1554754 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237663 1237663 1149410 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522893 1522893 1445265 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1334745 1334745 1245130 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20401612 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637695 2637695 2498068 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549159 2549159 2410614 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937532 1937532 1824466 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027864 2027864 1909767 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1483085 1483085 1406714 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21163115 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402514 2402514 2265370 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777294 1777294 1681297 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218528 2218528 2086539 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336427 1336427 1246812 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20430469 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402531 2402531 2265387 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095961 2095961 1974025 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1467309 1467309 1391155 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20940188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2406834 2406834 2269714 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 48 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230464 1230464 1142278 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174330 1174330 1086349 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777334 1777334 1681337 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525666 2525666 2387858 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591070 1591070 1512186 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680700 2680700 2539973 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 39 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542172 1542172 1464475 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264148 2264148 2131132 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1696873 1696873 1605001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22674612 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887387 1887387 1777059 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345353 2345353 2210025 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096130 2096130 1974194 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618837 1618837 1537589 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2350424 2350424 2214795 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23357969 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1097653 1097653 1012314 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425731 2425731 2288652 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838734 1838734 1732835 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680726 2680726 2539999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875682 1875682 1766265 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469374 1469374 1393113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173409 1173409 1085493 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960190 1960190 1846830 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1835518 1835518 1730550 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23242440 NS NS 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2136664 2136664 2006215 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422838 2422838 2285760 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2552472 2552472 2413913 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27553514 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469381 1469381 1393120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875680 1875680 1766263 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637185 1637185 1553233 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469436 1469436 1393175 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770517 1770517 1674757 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637257 1637257 1553305 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1697234 1697234 1605352 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21616658 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453431 1453431 1377464 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-17-K52205 2905639 2759895 NS NS NS NS malignant_melanoma NS NS NS n COSV51783368 COSM6196862 132564686 c.2086C>T p.P696S Substitution - Missense 38 7:55174758-55174758 + - PATHOGENIC .99382 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Pro696Ser ENST00000454757.6:c.2086C>T 7:g.55174758C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2841124 2841124 2696684 prostate NS NS NS carcinoma NS NS NS n COSV51806557 COSM6919399 132588470 c.2660G>A p.R887H Substitution - Missense 38 7:55198810-55198810 + - PATHOGENIC .99081 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000395243.3:p.Arg887His ENST00000454757.6:c.2660G>A 7:g.55198810G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-RT-S01771 1765129 1669449 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51780730 COSM22940 132551401 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 48 ENSP00000395243.3:p.Arg731His ENST00000454757.6:c.2192G>A 7:g.55181336G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-17-M17595 2905164 2759420 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51845233 COSM3734669 132553198 c.2083A>G p.I695V Substitution - Missense 38 7:55174755-55174755 + - PATHOGENIC .99591 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Ile695Val ENST00000454757.6:c.2083A>G 7:g.55174755A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SNU-638 2807650 2664351 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51777111 COSM33725 133215620 c.2474A>G p.H825R Substitution - Missense 38 7:55191858-55191858 + - PATHOGENIC .97748 Reported in another cancer sample as somatic 24807215 cell-line NS 48 ENSP00000415559.1:p.His825Arg ENST00000455089.5:c.2474A>G 7:g.55191858A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875806 1875806 1766389 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1816949 1816949 1716117 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1937547 1937547 1824481 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014116 1014116 931290 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2406810 2406810 2269690 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179659 1179659 1091621 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1197352 1197352 1109247 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 S001005 1027699 944675 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 2664374 2664374 2524430 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 54 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2906651 2906651 2760902 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29616327 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096286 2096286 1974350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081911 2081911 1960333 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2239169 2239169 2106701 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 99378223 c.2327G>A p.R776H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 48 ENSP00000275493.2:p.Arg776His ENST00000275493.6:c.2327G>A 7:g.55181336G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226883 2226883 2094618 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983699 1983699 1869935 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862718 2862718 2717881 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668524 1668524 1581817 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983742 1983742 1869978 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875382 1875382 1765965 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231309 1231309 1143099 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103754 1103754 1018006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 65 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-44-6147-01 1780126 1684125 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 67 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2822206 2822206 2678066 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1235342 178378585 c.? p.L62R Substitution - Missense + - Reported in another cancer sample as somatic 26373574 fixed - NOS NS ENSP00000275493.2:p.Leu62Arg EGFR ENST00000275493.6 3633 3236 KYSE-450 983846 899564 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense het + - Reported in another cancer sample as somatic 16707764 cell-line NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2595741 2595741 2456617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS 48 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2345118 2345118 2209790 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1042919 1042919 959260 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875375 1875375 1765958 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2372588 2372588 2235381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226884 2226884 2094619 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924345 924345 841120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891332 1891332 1780701 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2372593 2372593 2235386 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1046994 1046994 963225 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1098860 1098860 1013452 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891287 1891287 1780656 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983768 1983768 1870004 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891212 1891212 1780581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067061 1067061 983041 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1981032 1981032 1867268 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1549834 1549834 1471939 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1575156 1575156 1496597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897840 897840 815462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895134 1895134 1783826 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983829 1983829 1870065 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899342 899342 816954 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891176 1891176 1780545 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2057512 2057512 1937719 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24255770 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001303-T03-IM5 2719408 2578229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51807743 COSM133179 132566093 c.1930G>A p.V644M Substitution - Missense het 38 7:55173924-55173924 + - PATHOGENIC .9843 Reported in another cancer sample as somatic 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Val644Met ENST00000454757.6:c.1930G>A 7:g.55173924G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592872 1592872 1513798 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51807743 COSM133179 132566093 c.1930G>A p.V644M Substitution - Missense 38 7:55173924-55173924 + - PATHOGENIC .9843 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Val644Met ENST00000454757.6:c.1930G>A 7:g.55173924G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471803 1471803 1395541 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51827262 COSM53226 132561394 c.1964A>G p.N655S Substitution - Missense 38 7:55173958-55173958 + - PATHOGENIC .97158 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000395243.3:p.Asn655Ser ENST00000454757.6:c.1964A>G 7:g.55173958A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2007937 2007937 1890672 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23907151 fine needle aspirate metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983717 1983717 1869953 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875372 1875372 1765955 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899307 899307 816919 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1429327 1429327 1338778 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891207 1891207 1780576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1098872 1098872 1013464 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983731 1983731 1869967 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1573771 1573771 1495240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21982684 surgery fresh/frozen metastasis 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1103638 1103638 1017890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 62 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1891283 1891283 1780652 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770581 1770581 1674821 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1516786 1516786 1439380 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21575212 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095889 2095889 1973953 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983111 983111 898829 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083107 2083107 1961528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24300726 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264306 2264306 2131290 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874747 1874747 1765338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346538 2346538 2211201 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290951 2290951 2157016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2517306 2517306 2379655 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25282218 surgery - NOS NS 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345793 2345793 2210465 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096006 2096006 1974070 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770679 1770679 1674919 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422781 2422781 2285703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469400 1469400 1393139 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535020 1535020 1457355 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469377 1469377 1393116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542149 1542149 1464452 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014323 1014323 931497 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246649 1246649 1158328 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2209394 2209394 2077627 lung NS NS NS carcinoma signet_ring_cell_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25007143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665703 2665703 2525412 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS primary 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163050 2163050 2031634 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770692 1770692 1674932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459514 1459514 1383457 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777386 1777386 1681389 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656982 1656982 1571637 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22338650 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422917 2422917 2285839 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476867 2476867 2339636 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874734 1874734 1765325 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046037 2046037 1926332 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842980 1842980 1736228 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047780 2047780 1928052 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345514 2345514 2210186 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1532695 1532695 1455055 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20925915 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096149 2096149 1974213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1576793 1576793 1498234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21921847 surgery - NOS primary 86 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278192 1278192 1189490 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246709 1246709 1158388 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046626 2046626 1926920 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881891 1881891 1772042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046623 2046623 1926917 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345493 2345493 2210165 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770728 1770728 1674968 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1113266 1113266 1026765 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18449007 surgery fresh/frozen NS 42 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51832111 COSM6493934 133219841 c.2240T>A p.L747H Substitution - Missense het 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000415559.1:p.Leu747His ENST00000455089.5:c.2240T>A 7:g.55181384T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043129 1043129 959470 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51773049 COSM22943 133204348 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 31 ENSP00000415559.1:p.Pro803Leu ENST00000455089.5:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862733 2862733 2717896 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862733 2862733 2717896 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51796944 COSM28537 132554913 c.2425A>G p.T809A Substitution - Missense 38 7:55191809-55191809 + - PATHOGENIC .9858 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Thr809Ala ENST00000454757.6:c.2425A>G 7:g.55191809A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875337 1875337 1765920 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-024-tumor 2818985 2675284 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891224 1891224 1780593 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891296 1891296 1780665 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2205955 2205955 2074188 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914921 1914921 1802923 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542247 1542247 1464550 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21784628 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729757 1729757 1635728 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22805266 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2894937 2894937 2749420 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS primary 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1856347 1856347 1748900 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148604 2148604 2017734 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163048 2163048 2031632 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525687 2525687 2387876 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770536 1770536 1674776 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705494 1705494 1613400 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095921 2095921 1973985 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469360 1469360 1393099 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551546 1551546 1473651 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1140939 1140939 1053387 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448998 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425760 2425760 2288681 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960175 1960175 1846815 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1599063 1599063 1519550 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22091430 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345586 2345586 2210258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1498199 1498199 1421077 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21220471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2595741 2595741 2456617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS 48 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025401 2025401 1907490 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095964 2095964 1974028 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444791 1444791 1369034 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444758 1444758 1369001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083112 2083112 1961533 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24300726 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2482727 2482727 2345454 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26893581 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278197 1278197 1189495 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1696871 1696871 1604999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22674612 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095992 2095992 1974056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264092 2264092 2131076 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081911 2081911 1960333 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2686008 2686008 2545043 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025402 2025402 1907491 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770627 1770627 1674867 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1668675 1668675 1581967 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22523351 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095939 2095939 1974003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2865244 2865244 2720374 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29413048 surgery-fixed primary 82 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218548 2218548 2086559 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203091 2203091 2071349 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2265113 2265113 2132017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994671 cerebrospinal fluid metastasis 65 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1738892 1738892 1644723 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1981020 1981020 1867256 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302269 1302269 1213320 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1456554 1456554 1380529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860430 1860430 1751371 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429328 1429328 1338779 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1083998 1083998 999163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17785547 surgery fresh/frozen primary 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009165 2009165 1891899 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875343 1875343 1765926 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226865 2226865 2094600 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2616330 2616330 2476816 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26118982 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1493285 1493285 1416275 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20871266 fine needle aspirate metastasis 77 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983756 1983756 1869992 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891172 1891172 1780541 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098856 1098856 1013448 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001296-T02-IM5 2719406 2578227 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28481359 NS metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089606 1089606 1004553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1991299 1991299 1876634 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1734963 1734963 1640907 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 49 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226902 2226902 2094637 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1043124 1043124 959465 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51789261 COSM12986 99390495 c.2429G>A p.G810D Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98244 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 54 ENSP00000275493.2:p.Gly810Asp ENST00000275493.6:c.2429G>A 7:g.55181438G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453434 1453434 1377467 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592988 1592988 1513914 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899348 899348 816960 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 G73 1179731 1091693 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 58 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891310 1891310 1780679 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875339 1875339 1765922 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1200916 1200916 1112806 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602819 1602819 1522155 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1451204 1451204 1375347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860432 1860432 1751373 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1625787 1625787 1543011 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895088 1895088 1783780 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231323 1231323 1143113 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136864 1136864 1049428 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1197367 1197367 1109262 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166439 1166439 1078753 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 33 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1435996 1435996 1345275 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen NS 59 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668543 1668543 1581836 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895149 1895149 1783841 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226905 2226905 2094640 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2147914 2147914 2017057 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1107249 1107249 1021161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1135418 1135418 1047982 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891174 1891174 1780543 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924348 924348 841123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1098874 1098874 1013466 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1964315 1964315 1850850 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1435967 1435967 1345246 lung right_lower_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery-fixed primary 47 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1965924 1965924 1852417 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618801 1618801 1537553 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 61 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469859 1469859 1393598 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525736 2525736 2387924 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2015347 2015347 1897555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23963360 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618756 1618756 1537508 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 68 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2008974 2008974 1891708 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23979198 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027744 2027744 1909647 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2025437 2025437 1907526 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032222 2032222 1913693 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2612321 2612321 2473139 lung right NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28296233 circulating tumour metastasis 44 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746655 1746655 1651631 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 52 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00207T00207 2857359 2712659 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1549811 1549811 1471916 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 71 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 12 2570180 2431477 skin neck NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51798694 COSM18419 132613501 c.2065G>A p.E689K Substitution - Missense 38 7:55174737-55174737 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 60 ENSP00000395243.3:p.Glu689Lys ENST00000454757.6:c.2065G>A 7:g.55174737G>A EGFR ENST00000275493.6 3633 3236 1857886 1857886 1750376 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1169667 178383005 c.? p.C620Y Substitution - Missense + - Reported in another cancer sample as somatic 23243055 surgery-fixed recurrent ENSP00000275493.2:p.Cys620Tyr EGFR ENST00000275493.6 3633 3236 1879502 1879502 1770004 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1891332 1891332 1780701 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1082437 1082437 997655 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17649787 autopsy-fixed recurrent 32 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879504 1879504 1770006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879518 1879518 1770020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2113070 2113070 1987331 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 133203473 c.2117C>T p.T706I Substitution - Missense het 38 7:55174789-55174789 + - PATHOGENIC .99151 Reported in another cancer sample as somatic 24595526 surgery-fixed NS ENSP00000415559.1:p.Thr706Ile ENST00000455089.5:c.2117C>T 7:g.55174789C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231318 1231318 1143108 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983738 1983738 1869974 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862725 2862725 2717888 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1197355 1197355 1109250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594554 1594554 1515522 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1517068 1517068 1439662 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895164 1895164 1783856 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895137 1895137 1783829 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1200921 1200921 1112811 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-NYU1142 1765136 1669456 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924330 924330 841105 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089604 1089604 1004551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089138 1089138 1004092 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990913 1990913 1876248 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 IRG 897733 815355 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15118125 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2136611 2136611 2006162 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS 76 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2205990 2205990 2074223 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2225975 2225975 2093710 lung NS NS NS carcinoma NS NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24924582 fine needle aspirate NS ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891259 1891259 1780628 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897815 897815 815437 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429252 1429252 1338703 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983724 1983724 1869960 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077333 1077333 992587 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891197 1891197 1780566 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990911 1990911 1876246 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231325 1231325 1143115 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1459505 1459505 1383448 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430044 1430044 1339462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593029 1593029 1513955 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675681 2675681 2534955 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 2096246 2096246 1974310 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2595750 2595750 2456626 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1515239 1515239 1437849 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618821 1618821 1537573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547815 1547815 1469937 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed metastasis 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179670 1179670 1091632 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965924 1965924 1852417 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083473 2083473 1961756 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481316 surgery - NOS primary 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770649 1770649 1674889 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965868 1965868 1852361 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045994 2045994 1926289 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1532688 1532688 1455048 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20925915 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1635910 1635910 1552014 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22102479 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879537 1879537 1770039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983736 1983736 1869972 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 11-18 1731372 1637338 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22815900 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618801 1618801 1537553 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937563 1937563 1824497 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179652 1179652 1091614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469859 1469859 1393598 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264286 2264286 2131270 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000228 2000228 1885126 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770618 1770618 1674858 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996946 1996946 1882155 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 82 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2350429 2350429 2214800 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23357969 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542175 1542175 1464478 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996936 1996936 1882145 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 42 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587271 1587271 1508442 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141300 1141300 1053748 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1816948 1816948 1716116 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2011172 2011172 1893810 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120930 1120930 1034086 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2406814 2406814 2269694 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 47 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2033330 2033330 1914801 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24137465 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618756 1618756 1537508 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734162 1734162 1640111 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22843912 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214545 2214545 2082669 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1333760 1333760 1244218 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20395213 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1140932 1140932 1053380 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448998 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1592333 1592333 1513259 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20009914 surgery - NOS metastasis 46 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680761 2680761 2540034 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148643 2148643 2017773 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887395 1887395 1777067 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637150 1637150 1553198 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838684 1838684 1732785 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777251 1777251 1681254 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345562 2345562 2210234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1732976 1732976 1638925 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22833420 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535055 1535055 1457390 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983096 983096 898814 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515240 1515240 1437850 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2675405 2675405 2534679 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770727 1770727 1674967 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2562096 2562096 2423492 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218543 2218543 2086554 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226175 2226175 2093910 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141276 1141276 1053724 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637218 1637218 1553266 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174292 1174292 1086311 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637629 2637629 2498002 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 surgery - NOS primary 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838731 1838731 1732832 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046012 2046012 1926307 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591053 1591053 1512169 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659802 2659802 2519960 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 20 2570182 2431479 skin ear NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51778659 COSM14070 99374271 c.2588G>A p.G863D Substitution - Missense 38 7:55191837-55191837 + - PATHOGENIC .92688 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 70 ENSP00000275493.2:p.Gly863Asp ENST00000275493.6:c.2588G>A 7:g.55191837G>A EGFR ENST00000275493.6 3633 3236 1921913 1921913 1809231 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2350426 2350426 2214797 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23357969 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2612321 2612321 2473139 lung right NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28296233 circulating tumour metastasis 44 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2136662 2136662 2006213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141287 1141287 1053735 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421217 2421217 2284139 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120927 1120927 1034083 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 441-40 2605261 2466152 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25376516 surgery - NOS NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770617 1770617 1674857 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096137 2096137 1974201 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011168 2011168 1893806 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1110730 1110730 1024608 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18325048 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246683 1246683 1158362 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887413 1887413 1777085 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983155 983155 898873 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770542 1770542 1674782 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096122 2096122 1974186 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1733686 1733686 1639635 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22836289 surgery-fixed NS 52 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1789315 1789315 1692719 lung NS NS NS carcinoma NS NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00320T00320 2857338 2712638 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-273-tumor 2819121 2675420 meninges NS NS NS meningioma anaplastic NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1542173 1542173 1464476 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914933 1914933 1802935 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638724 1638724 1554723 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777359 1777359 1681362 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476892 2476892 2339661 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1732080 1732080 1638046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21622214 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878782 2878782 2733297 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22006985 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637199 1637199 1553247 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336842 1336842 1247227 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965892 1965892 1852385 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921892 1921892 1809210 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444799 1444799 1369042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1624109 1624109 1541696 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21681971 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966318 1966318 1852811 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2245038 2245038 2112314 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 CCRF-CEM 1760519 1665122 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51787208 COSM327142 99376659 c.3352G>A p.A1118T Substitution - Missense 38 7:55205336-55205336 + - NEUTRAL .10522 Reported in another cancer sample as somatic 22675565 cell-line NS ENSP00000275493.2:p.Ala1118Thr ENST00000275493.6:c.3352G>A 7:g.55205336G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00355T00355 2857331 2712631 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1881389 1881389 1771540 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CT31 1063205 979250 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 52 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CT31 1063205 979250 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 52 ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 2346491 2346491 2211154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2402748 2402748 2265601 breast NS NS NS carcinoma luminal_A_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 26267891 surgery-fixed primary 87 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659795 2659795 2519953 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773049 COSM22943 132549396 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Pro803Leu ENST00000454757.6:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SK-MEL-28 2651877 2512016 NS NS NS NS malignant_melanoma NS NS NS n COSV51778029 COSM6268 132554063 c.2122C>T p.P708S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 24336498 cell-line NS ENSP00000395243.3:p.Pro708Ser ENST00000454757.6:c.2122C>T 7:g.55174794C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00357T00357 2857360 2712660 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2079980 2079980 1958542 lung NS NS NS carcinoma signet_ring_cell_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24419120 surgery - NOS primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-208-tumor 2819090 2675389 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-023-tumor 2818984 2675283 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 3617 915988 833387 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51790305 COSM13194 132551901 c.2405C>T p.T802I Substitution - Missense 38 7:55191789-55191789 + - PATHOGENIC .95119 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000395243.3:p.Thr802Ile ENST00000454757.6:c.2405C>T 7:g.55191789C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1789324 1789324 1692728 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732924 2732924 2591677 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 64 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879563 1879563 1770065 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2073885 2073885 1953051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24370197 NS NS 46 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042855 1042855 959196 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1160959 1160959 1073295 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 19002495 surgery-fixed primary 62 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1879528 1879528 1770030 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1098870 1098870 1013462 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345519 2345519 2210191 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0125-01 1910168 1798459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 64 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450936 1450936 1375079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 77 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899310 899310 816922 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-14-R46791 2905653 2759909 NS NS NS NS malignant_melanoma NS NS NS n COSV51844648 COSM6971178 132555730 c.685A>G p.T229A Substitution - Missense 38 7:55154083-55154083 + - PATHOGENIC .96224 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000395243.3:p.Thr229Ala ENST00000454757.6:c.685A>G 7:g.55154083A>G EGFR ENST00000275493.6 3633 3236 1591048 1591048 1512164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM28739 178379146 c.? p.D761Y Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Asp761Tyr EGFR ENST00000275493.6 3633 3236 CL97 1790396 1693405 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23024022 cell-line NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 MG-230-tumor 2819105 2675404 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 MG-174-tumor 2819067 2675366 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1456558 1456558 1380533 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077371 1077371 992625 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2730697 2730697 2589468 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 99377339 c.2239_2240delinsCC p.L747P Substitution - Missense 38 7:55174776-55174777 + Yes Reported in another cancer sample as somatic 29673089 circulating tumour primary 54 ENSP00000275493.2:p.Leu747Pro ENST00000275493.6:c.2239_2240delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1576783 1576783 1498224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 63 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895064 1895064 1783756 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239167 2239167 2106699 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 35 ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 4515 915986 833385 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51849884 COSM13192 99382863 c.2428G>A p.G810S Substitution - Missense 38 7:55181437-55181437 + - PATHOGENIC .98229 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000275493.2:p.Gly810Ser ENST00000275493.6:c.2428G>A 7:g.55181437G>A EGFR ENST00000275493.6 3633 3236 924513 924513 841286 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1434026 1434026 1343441 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2203110 2203110 2071368 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008789 2008789 1891523 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046624 2046624 1926918 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1789323 1789323 1692727 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2007941 2007941 1890676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 132551512 c.2113G>C p.A705P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Reported in another cancer sample as somatic 23907151 fine needle aspirate metastasis ENSP00000395243.3:p.Ala705Pro ENST00000454757.6:c.2113G>C 7:g.55174785G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879566 1879566 1770068 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2372765 2372765 2235558 pleura NS NS NS mesothelioma NS NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24569782 surgery-fixed NS 72 ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1844328 1844328 1737362 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2625554 2625554 2485966 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1668542 1668542 1581835 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 PC-3 946056 862582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2479706 2479706 2342452 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 946825 946825 863348 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1434023 1434023 1343438 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1074999 1074999 990253 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 55 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1202563 1202563 1114449 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983832 1983832 1870068 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899350 899350 816962 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899306 899306 816918 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 V180 1179747 1091709 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042903 1042903 959244 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875383 1875383 1765966 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1981022 1981022 1867258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983740 1983740 1869976 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924338 924338 841113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077343 1077343 992597 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891279 1891279 1780648 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659805 2659805 2519963 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429279 1429279 1338730 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875794 1875794 1766377 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618661 1618661 1537413 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173460 1173460 1085544 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19057271 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1107776 1107776 1021679 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887402 1887402 1777074 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 899325 899325 816937 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875798 1875798 1766381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1005359 1005359 922571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 44 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602820 1602820 1522156 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450929 1450929 1375072 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 84 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1103631 1103631 1017883 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983739 1983739 1869975 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891201 1891201 1780570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042915 1042915 959256 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1005363 1005363 922575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 50 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1990901 1990901 1876236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226867 2226867 2094602 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1594594 1594594 1515562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1242316 1242316 1154046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19671738 surgery-fixed primary 56 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895123 1895123 1783815 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KT-4 1047094 963325 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17332333 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231314 1231314 1143104 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231319 1231319 1143109 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 914809 914809 832258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875379 1875379 1765962 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 907088 907088 824600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1166438 1166438 1078752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 77 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453430 1453430 1377463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891311 1891311 1780680 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2422466 2422466 2285388 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25521406 surgery - NOS metastasis 65 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043861 1043861 960202 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862787 2862787 2717950 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767280 COSM133183 99392721 c.2142G>C p.K714N Substitution - Missense 38 7:55174001-55174001 + - PATHOGENIC .89357 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Lys714Asn ENST00000275493.6:c.2142G>C 7:g.55174001G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732935 2732935 2591688 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 72 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450880 1450880 1375023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2161695 2161695 2030302 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24813888 surgery fresh/frozen recurrent 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2161695 2161695 2030302 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 24813888 surgery fresh/frozen recurrent 58 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1696883 1696883 1605011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 22674612 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2046177 2046177 1926472 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2218429 2218429 2086440 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25076890 surgery - NOS metastasis 79 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891192 1891192 1780561 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631956 1631956 1548826 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1054403 1054403 970474 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226887 2226887 2094622 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1202556 1202556 1114442 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-64-1681-01 1914034 1802316 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 61 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1991297 1991297 1876632 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1751712 1751712 1656528 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110468 1110468 1024346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453421 1453421 1377454 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1694971 1694971 1603191 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920167 920167 837247 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914807 914807 832256 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891179 1891179 1780548 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 911619 911619 829102 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1046993 1046993 963224 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602804 1602804 1522140 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042907 1042907 959248 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450925 1450925 1375068 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 61 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875365 1875365 1765948 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1202552 1202552 1114438 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895091 1895091 1783783 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891291 1891291 1780660 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067043 1067043 983023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239176 2239176 2106708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 47 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602811 1602811 1522147 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2136612 2136612 2006163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS 79 ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668440 1668440 1581733 upper_aerodigestive_tract trachea NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22526156 surgery-fixed primary 8 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593025 1593025 1513951 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2757126 2757126 2615769 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 132549057 c.2183A>T p.H728L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 29858019 circulating tumour recurrent 50 ENSP00000395243.3:p.His728Leu ENST00000454757.6:c.2183A>T 7:g.55181327A>T EGFR ENST00000275493.6 3633 3236 2078467 2078467 1957186 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 48 1858566 1750784 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM34167 178379046 c.? p.G598V Substitution - Missense + - Reported in another cancer sample as somatic 23262510 short-term culture NS 68 ENSP00000275493.2:p.Gly598Val EGFR ENST00000275493.6 3633 3236 2205964 2205964 2074197 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2684445 2684445 2543483 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 29128427 NS recurrent 44 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2684445 2684445 2543483 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29128427 NS recurrent 44 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 897811 897811 815433 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-275-tumor 2819122 2675421 meninges NS NS NS meningioma anaplastic NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 618-1503-04TD 1921502 1808820 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51797215 COSM145360 99385818 c.967G>A p.V323I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Reported in another cancer sample as somatic 340 blood NS ENSP00000275493.2:p.Val323Ile ENST00000275493.6:c.967G>A 7:g.55155907G>A EGFR ENST00000275493.6 3633 3236 2113071 2113071 1987332 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51787507 COSM13188 99385457 c.2281G>A p.D761N Substitution - Missense het 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 24595526 surgery-fixed NS ENSP00000275493.2:p.Asp761Asn ENST00000275493.6:c.2281G>A 7:g.55174818G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1093897 1093897 1008599 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18061305 pleural effusion NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042911 1042911 959252 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1542360 1542360 1464663 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844511 1844511 1737545 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23154768 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777411 1777411 1681414 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469375 1469375 1393114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2595740 2595740 2456616 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS 49 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2595740 2595740 2456616 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS 49 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-02-0007-01 1910125 1798416 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 133206822 c.652A>C p.T218P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 42 ENSP00000415559.1:p.Thr218Pro ENST00000455089.5:c.652A>C 7:g.55154050A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594565 1594565 1515533 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2345054 2345054 2209726 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1542361 1542361 1464664 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2422804 2422804 2285726 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302294 1302294 1213345 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001303-T03-IM5 2719408 2578229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891185 1891185 1780554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043863 1043863 960204 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005357 1005357 922569 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166441 1166441 1078755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 37 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166440 1166440 1078754 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043862 1043862 960203 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897819 897819 815441 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897823 897823 815445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043866 1043866 960207 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2239175 2239175 2106707 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 49 ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 2226916 2226916 2094651 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1734962 1734962 1640906 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 133204348 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 64 ENSP00000415559.1:p.Pro803Leu ENST00000455089.5:c.2408C>T 7:g.55191792C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2785975 2785975 2643435 large_intestine colon ascending NS carcinoma neuroendocrine_carcinoma NS NS n COSV51781835 COSM174732 133207258 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Reported in another cancer sample as somatic 28730258 surgery-fixed primary 61 ENSP00000415559.1:p.Glu114Lys ENST00000455089.5:c.340G>A 7:g.55143404G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 98 897199 814822 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15329413 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162203 1162203 1074535 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594125 1594125 1515050 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724887 surgery fresh/frozen NS 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914812 914812 832261 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136863 1136863 1049427 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194725 1194725 1106620 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 133205223 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Ala244Asp ENST00000455089.5:c.731C>A 7:g.55154129C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5325 915997 833396 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51789625 COSM13197 132549922 c.2455G>A p.A819T Substitution - Missense 38 7:55191839-55191839 + - PATHOGENIC .9615 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000395243.3:p.Ala819Thr ENST00000454757.6:c.2455G>A 7:g.55191839G>A EGFR ENST00000275493.6 3633 3236 2862118 2862118 2717320 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1637206 1637206 1553254 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1989947 1989947 1875286 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51789625 COSM13197 133204854 c.2455G>A p.A819T Substitution - Missense hom 38 7:55191839-55191839 + - PATHOGENIC .9615 Reported in another cancer sample as somatic 23585556 surgery-fixed primary ENSP00000415559.1:p.Ala819Thr ENST00000455089.5:c.2455G>A 7:g.55191839G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226773 2226773 2094508 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51823614 COSM4170219 132547383 c.2120C>T p.S707F Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98332 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Ser707Phe ENST00000454757.6:c.2120C>T 7:g.55174792C>T EGFR ENST00000275493.6 3633 3236 1777255 1777255 1681258 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105797 2105797 1983835 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096100 2096100 1974164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264287 2264287 2131271 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264312 2264312 2131296 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1891331 1891331 1780700 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891331 1891331 1780700 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1284671 1284671 1195966 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 16467085 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1887382 1887382 1777054 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1312424 1312424 1223333 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSM28574 178384302 c.? p.P848L Substitution - Missense + - Reported in another cancer sample as somatic 19723643 surgery-fixed NS 70 ENSP00000275493.2:p.Pro848Leu EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602805 1602805 1522141 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1648542 1648542 1563497 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1610923 1610923 1530151 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22157931 surgery-fixed metastasis 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372587 2372587 2235380 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1107242 1107242 1021154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891199 1891199 1780568 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302246 1302246 1213297 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372595 2372595 2235388 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2027345 2027345 1909413 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 40 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1202553 1202553 1114439 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2007943 2007943 1890678 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 132551512 c.2113G>C p.A705P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Reported in another cancer sample as somatic 23907151 fine needle aspirate metastasis ENSP00000395243.3:p.Ala705Pro ENST00000454757.6:c.2113G>C 7:g.55174785G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891314 1891314 1780683 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1879487 1879487 1769989 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879561 1879561 1770063 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1523014 1523014 1445386 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 72 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1523012 1523012 1445384 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 71 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675373 2675373 2534647 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767379 COSM85894 133213549 c.2392G>A p.V798I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000415559.1:p.Val798Ile ENST00000455089.5:c.2392G>A 7:g.55191776G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1881376 1881376 1771527 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166428 1166428 1078742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773206 COSM28603 132560955 c.2158G>A p.V720M Substitution - Missense het 38 7:55181302-55181302 + - PATHOGENIC .97963 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 67 ENSP00000395243.3:p.Val720Met ENST00000454757.6:c.2158G>A 7:g.55181302G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891263 1891263 1780632 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-18-K38789 2905357 2759613 gastrointestinal_tract_(site_indeterminate) NS NS NS carcinoma NS NS NS n COSV51816692 COSM6503372 132575469 c.2905G>A p.D969N Substitution - Missense 38 7:55201281-55201281 + - PATHOGENIC .99528 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000395243.3:p.Asp969Asn ENST00000454757.6:c.2905G>A 7:g.55201281G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 G73 1179731 1091693 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51780730 COSM22940 133206317 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 58 ENSP00000415559.1:p.Arg731His ENST00000455089.5:c.2192G>A 7:g.55181336G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450935 1450935 1375078 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 82 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042900 1042900 959241 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594127 1594127 1515050 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724887 surgery fresh/frozen NS 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668555 1668555 1581848 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2509046 2509046 2371381 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 132548259 c.1652C>T p.P551L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 62 ENSP00000395243.3:p.Pro551Leu ENST00000454757.6:c.1652C>T 7:g.55165344C>T EGFR ENST00000275493.6 3633 3236 1517053 1517053 1439647 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 49 ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450876 1450876 1375019 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 56 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1046998 1046998 963229 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429294 1429294 1338745 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2076211 2076211 1955023 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24406864 surgery-fixed primary 32 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1625793 1625793 1543017 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001300-T02-IM5 2719407 2578228 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 946819 946819 863342 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51803771 COSM14068 133219764 c.2173G>A p.D725N Substitution - Missense 38 7:55181317-55181317 + - PATHOGENIC .97623 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000415559.1:p.Asp725Asn ENST00000455089.5:c.2173G>A 7:g.55181317G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2817999 2817999 2674298 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31422893 pleural effusion metastasis 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1789318 1789318 1692722 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593011 1593011 1513937 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897829 897829 815451 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2078357 2078357 1957076 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24314215 pleural effusion NS 88 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891255 1891255 1780624 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875351 1875351 1765934 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226874 2226874 2094609 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453414 1453414 1377447 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891260 1891260 1780629 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631952 1631952 1548822 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891237 1891237 1780606 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1435997 1435997 1345276 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen primary 49 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-86-8075-01 1914090 1802372 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2000057 2000057 1884955 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS 51 ENSP00000275493.2:p.Glu709Lys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064711 2064711 1944788 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891184 1891184 1780553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983762 1983762 1869998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1738960 1738960 1644791 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1672196 1672196 1585384 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21917678 fine needle aspirate NS 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1517069 1517069 1439663 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429295 1429295 1338746 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1434024 1434024 1343439 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891225 1891225 1780594 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895119 1895119 1783811 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860421 1860421 1751362 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110451 1110451 1024329 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226919 2226919 2094654 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899334 899334 816946 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1038996 1038996 955573 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064713 2064713 1944790 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924335 924335 841110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2425782 2425782 2288703 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1664601 1664601 1578051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21899495 pericardial fluid NS 52 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2029030 2029030 1910912 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2684447 2684447 2543485 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29128427 circulating tumour recurrent 44 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2684447 2684447 2543485 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29128427 circulating tumour recurrent 44 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895168 1895168 1783860 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00192T00192 2857326 2712626 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00346T00346 2857341 2712641 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1135417 1135417 1047981 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891200 1891200 1780569 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-14-K41007 2905606 2759862 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 NPC0002PT00018T00018 2857363 2712663 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 MG-121-tumor 2819042 2675341 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136865 1136865 1049429 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103764 1103764 1018016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 72 ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103764 1103764 1018016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 72 ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 1705525 1705525 1613431 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481222 1481222 1404851 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2148650 2148650 2017780 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1445175 1445175 1369418 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 20682976 surgery - NOS metastasis 55 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525730 2525730 2387918 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 fine needle aspirate metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2476864 2476864 2339633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618655 1618655 1537407 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 72 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1031899 1031899 948690 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 17085664 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2105825 2105825 1983863 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2153116 2153116 2022126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2205984 2205984 2074217 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1994269 1994269 1879524 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23886169 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-156-tumor 2819056 2675355 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00143T00143 2857358 2712658 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103639 1103639 1017891 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51795632 COSM26509 132565559 c.2092G>A p.A698T Substitution - Missense 38 7:55174764-55174764 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 81 ENSP00000395243.3:p.Ala698Thr ENST00000454757.6:c.2092G>A 7:g.55174764G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-162-tumor 2819060 2675359 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 109598 2812902 2669316 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 44 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239176 2239176 2106708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51778029 COSM6268 132554063 c.2122C>T p.P708S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 47 ENSP00000395243.3:p.Pro708Ser ENST00000454757.6:c.2122C>T 7:g.55174794C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-RT-S01810 1765179 1669499 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51809160 COSM382935 132551562 c.1471G>A p.V491M Substitution - Missense 38 7:55161606-55161606 + - PATHOGENIC .98051 Reported in another cancer sample as somatic 22980975 surgery - NOS primary ENSP00000395243.3:p.Val491Met ENST00000454757.6:c.1471G>A 7:g.55161606G>A EGFR ENST00000275493.6 3633 3236 2239188 2239188 2106720 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777782 COSM6227 99381636 c.2504A>T p.H835L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 25130612 fine needle aspirate NS 75 ENSP00000275493.2:p.His835Leu ENST00000275493.6:c.2504A>T 7:g.55191753A>T EGFR ENST00000275493.6 3633 3236 2226916 2226916 2094651 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777782 COSM6227 99381636 c.2504A>T p.H835L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.His835Leu ENST00000275493.6:c.2504A>T 7:g.55191753A>T EGFR ENST00000275493.6 3633 3236 ESO-963 1890976 1780345 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV51799199 COSM1251020 99380942 c.1774G>A p.V592I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Reported in another cancer sample as somatic 23525077 surgery fresh/frozen primary 75 ENSP00000275493.2:p.Val592Ile ENST00000275493.6:c.1774G>A 7:g.55165331G>A EGFR ENST00000275493.6 3633 3236 TCGA-44-6147-01 1780126 1684125 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51811749 COSM6242 99389560 c.2305G>T p.V769L Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .9836 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 67 ENSP00000275493.2:p.Val769Leu ENST00000275493.6:c.2305G>T 7:g.55181314G>T EGFR ENST00000275493.6 3633 3236 S002024 1027695 944671 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51785554 COSM21688 99375522 c.971G>T p.R324L Substitution - Missense het 38 7:55155911-55155911 + - PATHOGENIC .97287 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Arg324Leu ENST00000275493.6:c.971G>T 7:g.55155911G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00426T00426 2857346 2712646 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983714 1983714 1869950 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1566942 1566942 1488711 upper_aerodigestive_tract pharynx oropharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 21953075 surgery fresh/frozen primary ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2078361 2078361 1957080 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24314215 pleural effusion NS 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895144 1895144 1783836 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1591044 1591044 1512160 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2028995 2028995 1910877 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777302 1777302 1681305 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965907 1965907 1852400 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421168 2421168 2284090 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705482 1705482 1613388 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542161 1542161 1464464 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1512590 1512590 1435274 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21508367 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345565 2345565 2210237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026248 2026248 1908337 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345531 2345531 2210203 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1635375 1635375 1551880 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22335887 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705525 1705525 1613431 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2864420 2864420 2719576 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26199566 surgery-fixed NS 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148650 2148650 2017780 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778774 2778774 2636828 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1000816 1000816 918039 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 16983123 autopsy - NOS metastasis 53 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1098876 1098876 1013468 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1789314 1789314 1692718 lung NS NS NS carcinoma NS NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897801 897801 815423 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1444776 1444776 1369019 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469475 1469475 1393214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 NSCLC-14 1325808 1236304 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20207772 surgery-fixed NS 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402516 2402516 2265372 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1355119 1355119 1265214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083472 2083472 1961755 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481316 surgery - NOS primary 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547825 1547825 1469947 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed metastasis 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983137 983137 898855 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2750883 2750883 2609579 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27086595 surgery-fixed NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1113040 1113040 1026541 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18458038 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230488 1230488 1142302 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618712 1618712 1537464 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591029 1591029 1512145 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965923 1965923 1852416 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476864 2476864 2339633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1052970 1052970 969041 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17410005 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1695732 1695732 1603944 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22673630 surgery - NOS primary 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096140 2096140 1974204 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264215 2264215 2131199 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474436 2474436 2337205 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226145 2226145 2093880 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476893 2476893 2339662 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1075802 1075802 991056 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17575133 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965274 1965274 1851769 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23803047 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025407 2025407 1907496 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2032066 2032066 1913537 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24103528 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887429 1887429 1777101 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469409 1469409 1393148 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2686022 2686022 2545057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474454 2474454 2337223 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2271430 2271430 2138060 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25257380 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638740 1638740 1554739 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637699 2637699 2498072 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279043 1279043 1190339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed metastasis 44 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045980 2045980 1926275 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1624150 1624150 1541737 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22000696 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000211 2000211 1885109 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118444 2118444 1992679 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095935 2095935 1973999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1154590 1154590 1066926 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18946755 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095894 2095894 1973958 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1768460 1768460 1672700 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22952784 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 HCC41T 1566756 1488563 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS n COSV51780707 COSM1251019 132568401 c.3323G>T p.S1108I Substitution - Missense het 38 7:55205442-55205442 + - NEUTRAL .36171 Reported in another cancer sample as somatic 323 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Ser1108Ile ENST00000454757.6:c.3323G>T 7:g.55205442G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897813 897813 815435 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895139 1895139 1783831 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1921911 1921911 1809229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2245052 2245052 2112328 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226177 2226177 2093912 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345594 2345594 2210266 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205974 2205974 2074207 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874663 1874663 1765254 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 924446 924446 841221 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 16198442 surgery - NOS recurrent 58 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1891215 1891215 1780584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302289 1302289 1213340 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1310474 1310474 1221419 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2076209 2076209 1955021 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24406864 surgery-fixed primary 38 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2864416 2864416 2719572 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26199566 surgery-fixed NS 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148592 2148592 2017722 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046033 2046033 1926328 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118426 2118426 1992661 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105798 2105798 1983836 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637190 1637190 1553238 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096003 2096003 1974067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173400 1173400 1085484 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914947 1914947 1802949 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336416 1336416 1246801 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20430469 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1879425 1879425 1769930 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23464964 surgery-fixed NS 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986151 1986151 1872387 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230475 1230475 1142289 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878847 2878847 2733362 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27368130 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551482 1551482 1473587 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770562 1770562 1674802 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777341 1777341 1681344 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986164 1986164 1872400 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983125 983125 898843 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591057 1591057 1512173 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2156960 2156960 2025935 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000057 2000057 1884955 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264091 2264091 2131075 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045996 2045996 1926291 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205965 2205965 2074198 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228771 2228771 2096483 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24956168 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1075909 1075909 991163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875364 1875364 1765947 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2239175 2239175 2106707 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51777782 COSM6227 99381636 c.2504A>T p.H835L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 49 ENSP00000275493.2:p.His835Leu ENST00000275493.6:c.2504A>T 7:g.55191753A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226772 2226772 2094507 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51782925 COSM24267 133205309 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu702Pro ENST00000455089.5:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1094000 1094000 1008702 urinary_tract bladder NS NS carcinoma NS NS NS n COSV51816100 COSM13430 133227287 c.2380G>A p.A794T Substitution - Missense 38 7:55191764-55191764 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 17707060 surgery fresh/frozen NS ENSP00000415559.1:p.Ala794Thr ENST00000455089.5:c.2380G>A 7:g.55191764G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891314 1891314 1780683 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1661375 1661375 1574990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 22483783 surgery-fixed NS 82 ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891278 1891278 1780647 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1549822 1549822 1471927 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089607 1089607 1004554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875370 1875370 1765953 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895167 1895167 1783859 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-RT-S01771 1765129 1669449 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 48 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1052738 1052738 968809 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17368623 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1610918 1610918 1530146 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22157931 surgery-fixed primary 55 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CT19 1063199 979244 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1648544 1648544 1563499 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043853 1043853 960194 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1876997 1876997 1767559 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860424 1860424 1751365 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136884 1136884 1049448 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1135422 1135422 1047986 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1587192 1587192 1508363 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS 50 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1770512 1770512 1674752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1534106 1534106 1456445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21707848 surgery-fixed primary 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1197351 1197351 1109246 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1046999 1046999 963230 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895079 1895079 1783771 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1197353 1197353 1109248 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453495 1453495 1377528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450943 1450943 1375086 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-91-6835-01 1780237 1684236 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 81 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983827 1983827 1870063 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862715 2862715 2717878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862100 2862100 2717302 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51830861 COSM6219 132551512 c.2113G>C p.A705P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000395243.3:p.Ala705Pro ENST00000454757.6:c.2113G>C 7:g.55174785G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 11-18-GEF20-1 1731376 1637342 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22815900 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1672451 1672451 1585505 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21729655 surgery-fixed metastasis 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879568 1879568 1770070 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1024780 1024780 941757 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-NYU1142 1765136 1669456 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 72 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1141191 1141191 1053639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 18785203 autopsy-fixed NS 78 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1040049 1040049 956626 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17180521 surgery - NOS recurrent 57 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879507 1879507 1770009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778771 2778771 2636825 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980061 1980061 1866304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 69 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-70-6722-01 1783058 1687057 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 418 fresh/frozen - NOS primary 47 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895076 1895076 1783768 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897285 897285 814908 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 15118073 surgery-fixed primary 58 ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879578 1879578 1770080 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1000060 1000060 917283 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879530 1879530 1770032 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1242316 1242316 1154046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777111 COSM33725 132559461 c.2474A>G p.H825R Substitution - Missense het 38 7:55191858-55191858 + - PATHOGENIC .97748 Reported in another cancer sample as somatic 19671738 surgery-fixed primary 56 ENSP00000395243.3:p.His825Arg ENST00000454757.6:c.2474A>G 7:g.55191858A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879534 1879534 1770036 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2509062 2509062 2371397 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_II pleomorphic_xanthoastrocytoma NS n COSV51822879 COSM4680399 132555327 c.1904G>A p.R635Q Substitution - Missense 38 7:55173102-55173102 + - PATHOGENIC .99814 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 16 ENSP00000395243.3:p.Arg635Gln ENST00000454757.6:c.1904G>A 7:g.55173102G>A EGFR ENST00000275493.6 3633 3236 BL-17-J45330 2905663 2759919 NS NS NS NS malignant_melanoma NS NS NS n COSV51777851 COSM1205052 99395067 c.494G>A p.R165Q Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .0375 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Arg165Gln ENST00000275493.6:c.494G>A 7:g.55146675G>A EGFR ENST00000275493.6 3633 3236 899343 899343 816955 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897837 897837 815459 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897816 897816 815438 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1549817 1549817 1471922 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 82 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1576797 1576797 1498238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 66 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1992090 1992090 1877407 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 63 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1891290 1891290 1780659 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891226 1891226 1780595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1231324 1231324 1143114 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1197363 1197363 1109258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875796 1875796 1766379 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1320683 1320683 1231570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20155428 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2734339 2734339 2593066 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 29731638 circulating tumour recurrent 52 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1098816 1098816 1013408 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DM2 2466860 2329691 skin face NS NS malignant_melanoma desmoplastic NS NS n COSV51781503 COSM5608352 132568875 c.1774C>T p.P592S Substitution - Missense 38 7:55171203-55171203 + - NEUTRAL .1586 Reported in another cancer sample as somatic 26343386 surgery-fixed NS 86 ENSP00000395243.3:p.Pro592Ser ENST00000454757.6:c.1774C>T 7:g.55171203C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DM2 2466860 2329691 skin face NS NS malignant_melanoma desmoplastic NS NS n COSV51800313 COSM5608354 132549848 c.2137G>A p.E713K Substitution - Missense 38 7:55174809-55174809 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 26343386 surgery-fixed NS 86 ENSP00000395243.3:p.Glu713Lys ENST00000454757.6:c.2137G>A 7:g.55174809G>A EGFR ENST00000275493.6 3633 3236 MG-201-tumor 2819084 2675383 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043871 1043871 960212 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895107 1895107 1783799 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302278 1302278 1213329 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895104 1895104 1783796 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895101 1895101 1783793 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895136 1895136 1783828 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899329 899329 816941 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875374 1875374 1765957 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1083997 1083997 999162 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17785547 surgery fresh/frozen primary 52 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897833 897833 815455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 21 1433986 1343401 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PC-9 946058 862584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920133 920133 837213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924525 924525 841298 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136876 1136876 1049440 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895086 1895086 1783778 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983735 1983735 1869971 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631959 1631959 1548829 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453423 1453423 1377456 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895092 1895092 1783784 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1500180 1500180 1423059 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-38-4627-01 1780091 1684090 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983715 1983715 1869951 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042909 1042909 959250 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2078354 2078354 1957073 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24314215 fine needle aspirate NS 57 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879545 1879545 1770047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879482 1879482 1769984 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879238 1879238 1769793 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23468066 fine needle aspirate NS 81 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862074 2862074 2717281 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 32122695 surgery - NOS NS 62 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042854 1042854 959195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1295349 1295349 1206428 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 19884551 surgery fresh/frozen NS ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136873 1136873 1049437 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2290970 2290970 2157035 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1230493 1230493 1142307 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2046184 2046184 1926479 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345089 2345089 2209761 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1705532 1705532 1613438 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2029019 2029019 1910901 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675161 2675161 2534435 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766284 COSM28512 133205611 c.2095A>G p.I699V Substitution - Missense 38 7:55174767-55174767 + - PATHOGENIC .99591 Reported in another cancer sample as somatic 29075127 surgery fresh/frozen NS ENSP00000415559.1:p.Ile699Val ENST00000455089.5:c.2095A>G 7:g.55174767A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-D1-A174-01 1783520 1687519 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51769863 COSM1090888 133209747 c.2089G>A p.V697I Substitution - Missense hom 38 7:55174761-55174761 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 51 ENSP00000415559.1:p.Val697Ile ENST00000455089.5:c.2089G>A 7:g.55174761G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2701198 2701198 2560102 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing_non_differentiated NS n COSV51769863 COSM1090888 133209747 c.2089G>A p.V697I Substitution - Missense het 38 7:55174761-55174761 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 28581676 surgery-fixed NS 48 ENSP00000415559.1:p.Val697Ile ENST00000455089.5:c.2089G>A 7:g.55174761G>A EGFR ENST00000275493.6 3633 3236 1593029 1593029 1513955 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1047910 1047910 964139 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17335935 pleural effusion recurrent 83 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1973999 1973999 1860241 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1882612 1882612 1772747 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23493804 pleural effusion metastasis 72 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SJHGG120_D 2307435 2172639 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 24705251 surgery - NOS NS 12 ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00278T00278 2857364 2712664 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00305T00305 2857328 2712628 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-197-tumor 2819082 2675381 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2476907 2476907 2339676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM24429 178380423 c.? p.E709G Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Glu709Gly EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1168008 1168008 1080250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1202559 1202559 1114445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897818 897818 815440 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875338 1875338 1765921 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897827 897827 815449 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231328 1231328 1143118 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 984658 984658 900313 lung right_middle_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16619582 surgery-fixed primary 51 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042920 1042920 959261 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593000 1593000 1513926 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891186 1891186 1780555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1197356 1197356 1109251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924346 924346 841121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2076210 2076210 1955022 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51767182 COSM27110 132554778 c.2221G>A p.V741M Substitution - Missense het 38 7:55181365-55181365 + - PATHOGENIC .97319 Reported in another cancer sample as somatic 24406864 surgery-fixed primary 87 ENSP00000395243.3:p.Val741Met ENST00000454757.6:c.2221G>A 7:g.55181365G>A EGFR ENST00000275493.6 3633 3236 TCGA-AX-A0J0-01 1783376 1687375 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51770777 COSM28286 99393107 c.2494C>T p.R832C Substitution - Missense het 38 7:55191743-55191743 + - PATHOGENIC .95135 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 47 ENSP00000275493.2:p.Arg832Cys ENST00000275493.6:c.2494C>T 7:g.55191743C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592997 1592997 1513923 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098811 1098811 1013403 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18186961 surgery - NOS primary 61 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895093 1895093 1783785 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891246 1891246 1780615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1876991 1876991 1767553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077329 1077329 992583 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0002PT00038T00038 2857332 2712632 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1876985 1876985 1767547 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891228 1891228 1780597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226872 2226872 2094607 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1991301 1991301 1876636 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895073 1895073 1783765 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1038995 1038995 955572 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1573765 1573765 1495234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21982684 surgery fresh/frozen metastasis 44 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1 1433966 1343381 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2758808 2758808 2617370 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28762784 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2064723 2064723 1944800 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1534107 1534107 1456446 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21707848 surgery-fixed metastasis 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862728 2862728 2717891 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875354 1875354 1765937 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2078351 2078351 1957070 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24314215 pleural effusion NS 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1000057 1000057 917280 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2629460 2629460 2489844 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51769863 COSM1090888 133209747 c.2089G>A p.V697I Substitution - Missense 38 7:55174761-55174761 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 26317919 surgery-fixed NS 63 ENSP00000415559.1:p.Val697Ile ENST00000455089.5:c.2089G>A 7:g.55174761G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1451644 1451644 1375787 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51829458 COSM51497 133209395 c.2102_2103inv p.E701V Substitution - Missense 38 7:55174774-55174775 + - Reported in another cancer sample as somatic 20855820 surgery - NOS NS ENSP00000415559.1:p.Glu701Val ENST00000455089.5:c.2102_2103inv 7:g.55174774_55174775inv EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593033 1593033 1513959 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51784752 COSM13199 133204015 c.2483G>A p.G828E Substitution - Missense 38 7:55191867-55191867 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Gly828Glu ENST00000455089.5:c.2483G>A 7:g.55191867G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064721 2064721 1944798 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668461 1668461 1581754 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914804 914804 832253 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1882511 1882511 1772647 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767827 COSM1235378 132569177 c.2425A>T p.T809S Substitution - Missense hom 38 7:55191809-55191809 + - PATHOGENIC .98595 Reported in another cancer sample as somatic 23486275 NS NS 54 ENSP00000395243.3:p.Thr809Ser ENST00000454757.6:c.2425A>T 7:g.55191809A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-05-5423-01 1780079 1684078 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 65 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891297 1891297 1780666 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895171 1895171 1783863 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 18 2570181 2431478 skin face NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51773206 COSM28603 132560955 c.2158G>A p.V720M Substitution - Missense 38 7:55181302-55181302 + - PATHOGENIC .97963 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 53 ENSP00000395243.3:p.Val720Met ENST00000454757.6:c.2158G>A 7:g.55181302G>A EGFR ENST00000275493.6 3633 3236 1024775 1024775 941752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 surgery fresh/frozen recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2733535 2733535 2592288 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29704676 circulating tumour recurrent 36 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2778772 2778772 2636826 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879235 1879235 1769790 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23468066 surgery-fixed NS 55 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1522943 1522943 1445315 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 63 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1891320 1891320 1780689 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51832101 COSM6493933 99392449 c.2374C>T p.L792F Substitution - Missense het 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000275493.2:p.Leu792Phe ENST00000275493.6:c.2374C>T 7:g.55181383C>T EGFR ENST00000275493.6 3633 3236 2239169 2239169 2106701 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25130612 surgery - NOS NS 48 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1856184 1856184 1748737 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS metastasis ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862770 2862770 2717933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 132560202 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + - PATHOGENIC .95568 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862074 2862074 2717281 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 32122695 surgery - NOS NS 62 ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602809 1602809 1522145 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879556 1879556 1770058 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2205953 2205953 2074186 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838678 1838678 1732779 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264170 2264170 2131154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1 1077300 992554 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668466 1668466 1581759 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51795632 COSM26509 132565559 c.2092G>A p.A698T Substitution - Missense 38 7:55174764-55174764 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Ala698Thr ENST00000454757.6:c.2092G>A 7:g.55174764G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CT13 1063196 979241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 57 ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 DCR7 1690657 1598934 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 99388924 c.1476C>A p.S492R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000275493.2:p.Ser492Arg ENST00000275493.6:c.1476C>A 7:g.55160316C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983707 1983707 1869943 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879536 1879536 1770038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1523013 1523013 1445385 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 60 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2819295 2819295 2675594 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 30711944 pleural effusion recurrent 63 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879553 1879553 1770055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659810 2659810 2519968 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2076202 2076202 1955015 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 24389444 surgery-fixed NS 77 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064718 2064718 1944795 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1996917 1996917 1882126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 44 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2205991 2205991 2074224 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1098816 1098816 1013408 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1839254 1839254 1733355 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51776282 COSM1168015 99373518 c.2258C>T p.P753L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Reported in another cancer sample as somatic 23244191 surgery-fixed primary ENSP00000275493.2:p.Pro753Leu ENST00000275493.6:c.2258C>T 7:g.55174795C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879572 1879572 1770074 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2161697 2161697 2030304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24813888 surgery - NOS recurrent 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1770656 1770656 1674896 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879229 1879229 1769784 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51792805 COSM13005 132549057 c.2183A>T p.H728L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 23468066 fine needle aspirate NS 39 ENSP00000395243.3:p.His728Leu ENST00000454757.6:c.2183A>T 7:g.55181327A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983766 1983766 1870002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895116 1895116 1783808 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891295 1891295 1780664 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2046030 2046030 1926325 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2805811 2805811 2662548 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 31348837 surgery - NOS NS ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 1355103 1355103 1265198 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966336 1966336 1852829 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1194736 1194736 1106631 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879238 1879238 1769793 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 23468066 fine needle aspirate NS 81 ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983777 1983777 1870013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891336 1891336 1780705 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983733 1983733 1869969 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895141 1895141 1783833 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1107248 1107248 1021160 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067075 1067075 983055 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862090 2862090 2717292 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1567520 1567520 1489152 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21949883 fine needle aspirate metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226920 2226920 2094655 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1576802 1576802 1498243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 surgery - NOS primary 47 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879503 1879503 1770005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1493285 1493285 1416275 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 20871266 fine needle aspirate metastasis 77 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1816951 1816951 1716119 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001296-T02-IM5 2719406 2578227 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 28481359 NS metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2675011 2675011 2534306 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29110841 surgery - NOS metastasis 49 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1705345 1705345 1613329 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51769815 COSM249886 133229603 c.1961C>T p.P654L Substitution - Missense 38 7:55173955-55173955 + - PATHOGENIC .97389 Reported in another cancer sample as somatic 22722798 surgery - NOS recurrent 71 ENSP00000415559.1:p.Pro654Leu ENST00000455089.5:c.1961C>T 7:g.55173955C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891337 1891337 1780706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110452 1110452 1024330 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2073269 2073269 1952508 upper_aerodigestive_tract sinonasal_and_nasal_cavity NS NS carcinoma adenocarcinoma intestinal NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24338245 surgery-fixed NS 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226892 2226892 2094627 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302247 1302247 1213298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS 61 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983830 1983830 1870066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602799 1602799 1522135 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983727 1983727 1869963 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1694969 1694969 1603189 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 49 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479940 1479940 1403600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 V80 1179749 1091711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 79 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891262 1891262 1780631 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1456576 1456576 1380551 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899336 899336 816948 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-46-3769-01 1781825 1685824 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51799159 COSM747427 132570646 c.1631C>T p.P544L Substitution - Missense 38 7:55165323-55165323 + - PATHOGENIC .95834 Reported in another cancer sample as somatic 418 fresh/frozen - NOS primary 57 ENSP00000395243.3:p.Pro544Leu ENST00000454757.6:c.1631C>T 7:g.55165323C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1881379 1881379 1771530 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1032022 1032022 948813 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17060940 pleural effusion NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602800 1602800 1522136 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453413 1453413 1377446 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 G36 1063244 979289 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226903 2226903 2094638 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2479713 2479713 2342459 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51780877 COSM26717 133203719 c.2444A>T p.K815I Substitution - Missense het 38 7:55191828-55191828 + - PATHOGENIC .95726 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000415559.1:p.Lys815Ile ENST00000455089.5:c.2444A>T 7:g.55191828A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983712 1983712 1869948 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1500182 1500182 1423061 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162653 1162653 1074985 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19010870 surgery - NOS metastasis 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 911624 911624 829107 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668554 1668554 1581847 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983703 1983703 1869939 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899323 899323 816935 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077336 1077336 992590 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1573760 1573760 1495229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21982684 surgery fresh/frozen primary 76 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372589 2372589 2235382 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110448 1110448 1024326 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042858 1042858 959199 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891167 1891167 1780536 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2479712 2479712 2342458 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990899 1990899 1876234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875804 1875804 1766387 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1074885 1074885 990139 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17505415 surgery fresh/frozen primary 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00190T00190 2857342 2712642 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00243T00243 2857340 2712640 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042856 1042856 959197 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732896 2732896 2591649 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 58 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2808102 2808102 2664786 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 31258848 surgery-fixed NS 60 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592973 1592973 1513899 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51803771 COSM14068 133219764 c.2173G>A p.D725N Substitution - Missense 38 7:55181317-55181317 + - PATHOGENIC .97623 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Asp725Asn ENST00000455089.5:c.2173G>A 7:g.55181317G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453417 1453417 1377450 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 11 2570179 2431476 skin face NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51775222 COSM13189 132558076 c.2216C>T p.S739F Substitution - Missense 38 7:55181360-55181360 + - PATHOGENIC .94833 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 65 ENSP00000395243.3:p.Ser739Phe ENST00000454757.6:c.2216C>T 7:g.55181360C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1991359 1991359 1876694 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659798 2659798 2519956 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 6374 915984 833383 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51860329 COSM13190 99392465 c.2375T>C p.L792P Substitution - Missense 38 7:55181384-55181384 + - PATHOGENIC .95089 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000275493.2:p.Leu792Pro ENST00000275493.6:c.2375T>C 7:g.55181384T>C EGFR ENST00000275493.6 3633 3236 1074948 1074948 990202 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891334 1891334 1780703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1734960 1734960 1640904 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 33 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891202 1891202 1780571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1197366 1197366 1109261 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983701 1983701 1869937 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042902 1042902 959243 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226885 2226885 2094620 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1990906 1990906 1876241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2064719 2064719 1944796 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2625562 2625562 2485974 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 51 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1668525 1668525 1581818 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899317 899317 816929 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KTA-7 946051 862577 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592976 1592976 1513902 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51792805 COSM13005 133203995 c.2183A>T p.H728L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.His728Leu ENST00000455089.5:c.2183A>T 7:g.55181327A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136881 1136881 1049445 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2680654 2680654 2539927 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 63 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1592888 1592888 1513814 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1567592 1567592 1489224 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21949883 fine needle aspirate metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1162207 1162207 1074539 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766880 COSM28516 99392483 c.2404G>T p.V802F Substitution - Missense 38 7:55181413-55181413 + - PATHOGENIC .89385 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000275493.2:p.Val802Phe ENST00000275493.6:c.2404G>T 7:g.55181413G>T EGFR ENST00000275493.6 3633 3236 2625554 2625554 2485966 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2562099 2562099 2423495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000056 2000056 1884954 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS 82 ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 2000056 2000056 1884954 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS 82 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1481218 1481218 1404847 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895094 1895094 1783786 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1627724 1627724 1544636 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592996 1592996 1513922 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009145 2009145 1891879 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 G36 1063244 979289 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 73 ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 1983825 1983825 1870061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899327 899327 816939 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983776 1983776 1870012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1456552 1456552 1380527 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1075002 1075002 990256 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 55 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302274 1302274 1213325 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897800 897800 815422 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CT13 1063196 979241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 57 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 18 2570181 2431478 skin face NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51774667 COSM53194 132555352 c.2062C>T p.P688S Substitution - Missense 38 7:55174734-55174734 + - PATHOGENIC .99806 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 53 ENSP00000395243.3:p.Pro688Ser ENST00000454757.6:c.2062C>T 7:g.55174734C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897810 897810 815432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BC1-1 2824183 2680011 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51787208 COSM327142 132549881 c.3217G>A p.A1073T Substitution - Missense 38 7:55205336-55205336 + - NEUTRAL .10522 Reported in another cancer sample as somatic 31867841 circulating tumour recurrent 54 ENSP00000395243.3:p.Ala1073Thr ENST00000454757.6:c.3217G>A 7:g.55205336G>A EGFR ENST00000275493.6 3633 3236 1891334 1891334 1780703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879512 1879512 1770014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2011188 2011188 1893826 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM24429 178380423 c.? p.E709G Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Glu709Gly EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1107243 1107243 1021155 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 109610 2812911 2669325 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 16 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862711 2862711 2717874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765252 COSM13009 132568674 c.1991A>G p.E664G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Glu664Gly ENST00000454757.6:c.1991A>G 7:g.55173985A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862711 2862711 2717874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2579268 2579268 2440605 NS NS NS NS malignant_melanoma NS NS NS n COSV51778029 COSM6268 132554063 c.2122C>T p.P708S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000395243.3:p.Pro708Ser ENST00000454757.6:c.2122C>T 7:g.55174794C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042905 1042905 959246 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879506 1879506 1770008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 8LFG8F 2762947 2621206 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51839851 COSM7340115 132572537 c.983C>A p.P328Q Substitution - Missense 38 7:55156644-55156644 + - PATHOGENIC .76649 Reported in another cancer sample as somatic 29615459 NS metastasis 45 ENSP00000395243.3:p.Pro328Gln ENST00000454757.6:c.983C>A 7:g.55156644C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592887 1592887 1513813 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1751716 1751716 1656532 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1336832 1336832 1247217 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705526 1705526 1613432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1705526 1705526 1613432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493354 1493354 1416344 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549147 2549147 2410602 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1668551 1668551 1581844 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0000205-T01-IM3 2714809 2573630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895103 1895103 1783795 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2659804 2659804 2519962 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1479949 1479949 1403609 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1434019 1434019 1343434 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1530684 1530684 1453056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21227397 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2625551 2625551 2485963 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1479915 1479915 1403575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1046995 1046995 963226 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897824 897824 815446 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2625563 2625563 2485975 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 51 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1789320 1789320 1692724 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983726 1983726 1869962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1456618 1456618 1380593 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450858 1450858 1375001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1141192 1141192 1053640 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 18785203 surgery-fixed NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549120 2549120 2410575 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2026239 2026239 1908328 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51793933 COSM250050 133268287 c.2435G>A p.G812E Substitution - Missense het 38 7:55191819-55191819 + - PATHOGENIC .98882 Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000415559.1:p.Gly812Glu ENST00000455089.5:c.2435G>A 7:g.55191819G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043129 1043129 959470 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 31 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879550 1879550 1770052 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879490 1879490 1769992 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879484 1879484 1769986 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 WG05T 2653265 2513392 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS primary 58.29 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862730 2862730 2717893 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 57 2760165 2618698 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51780766 COSM219795 132546924 c.2456C>T p.A819V Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .93098 Reported in another cancer sample as somatic 29876005 surgery-fixed NS ENSP00000395243.3:p.Ala819Val ENST00000454757.6:c.2456C>T 7:g.55191840C>T EGFR ENST00000275493.6 3633 3236 2271425 2271425 2138057 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25257380 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194728 1194728 1106623 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1513410 1513410 1436071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21497370 fixed - NOS metastasis ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1715966 1715966 1623528 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 22760226 surgery - NOS NS 70 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2862255 2862255 2717445 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25969368 surgery-fixed primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2675413 2675413 2534687 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 924331 924331 841106 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1631942 1631942 1548812 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625600 2625600 2486012 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 44 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043125 1043125 959466 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 43 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1522949 1522949 1445321 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 74 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879539 1879539 1770041 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980063 1980063 1866306 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 60 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005360 1005360 922572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891187 1891187 1780556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602816 1602816 1522152 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1734965 1734965 1640909 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2147913 2147913 2017056 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 55 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592982 1592982 1513908 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875369 1875369 1765952 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860420 1860420 1751361 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1884157 1884157 1774044 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1648543 1648543 1563498 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895100 1895100 1783792 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 V104 1179745 1091707 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1500183 1500183 1423062 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860426 1860426 1751367 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 B127 1179748 1091710 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1054395 1054395 970466 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983695 1983695 1869931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1549819 1549819 1471924 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1443061 1443061 1367346 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20837450 surgery - NOS primary 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136888 1136888 1049452 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895082 1895082 1783774 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1648546 1648546 1563501 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043134 1043134 959475 upper_aerodigestive_tract tonsil NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51793896 COSM22954 132561366 c.2189G>A p.C730Y Substitution - Missense 38 7:55181333-55181333 + - PATHOGENIC .97278 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 53 ENSP00000395243.3:p.Cys730Tyr ENST00000454757.6:c.2189G>A 7:g.55181333G>A EGFR ENST00000275493.6 3633 3236 1983757 1983757 1869993 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002085-T01-IM3 2718386 2577207 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002085-T01-IM3 2718386 2577207 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767827 COSM1235378 133226447 c.2425A>T p.T809S Substitution - Missense het 38 7:55191809-55191809 + - PATHOGENIC .98595 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr809Ser ENST00000455089.5:c.2425A>T 7:g.55191809A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1000051 1000051 917274 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231326 1231326 1143116 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899303 899303 816915 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1648541 1648541 1563496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2733228 2733228 2591981 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 132548259 c.1652C>T p.P551L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 61 ENSP00000395243.3:p.Pro551Leu ENST00000454757.6:c.1652C>T 7:g.55165344C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-38-4627-01 1780091 1684090 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 64 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 G37 1063245 979290 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 70 ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899332 899332 816944 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162653 1162653 1074985 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51796944 COSM28537 133210567 c.2425A>G p.T809A Substitution - Missense het 38 7:55191809-55191809 + - PATHOGENIC .9858 Reported in another cancer sample as somatic 19010870 surgery - NOS metastasis 69 ENSP00000415559.1:p.Thr809Ala ENST00000455089.5:c.2425A>G 7:g.55191809A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2027346 2027346 1909414 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 56 ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1996950 1996950 1882159 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 59 ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920158 920158 837238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 67 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2676600 2676600 2535874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 28939152 NS NS 35 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879240 1879240 1769795 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23468066 pleural effusion NS 73 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1894920 1894920 1783612 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668448 1668448 1581741 lung bronchus NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22526156 surgery-fixed primary 25 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659760 2659760 2519918 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 2136614 2136614 2006165 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS 67 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1530684 1530684 1453056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21227397 surgery-fixed NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1278399 1278399 1189695 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19596957 cerebrospinal fluid metastasis 51 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1980078 1980078 1866321 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 60 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2778768 2778768 2636822 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2007939 2007939 1890674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23907151 fine needle aspirate primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625549 2625549 2485961 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1876987 1876987 1767549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009159 2009159 1891893 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659808 2659808 2519966 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897847 897847 815469 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2057511 2057511 1937718 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24255770 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162204 1162204 1074536 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1202562 1202562 1114448 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103769 1103769 1018021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NCI-H1975 1047098 963329 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17332333 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594592 1594592 1515560 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1083995 1083995 999160 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17785547 surgery fresh/frozen primary 83 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914805 914805 832254 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent 52 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372592 2372592 2235385 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302288 1302288 1213339 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077335 1077335 992589 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668473 1668473 1581766 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875385 1875385 1765968 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1107250 1107250 1021162 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924341 924341 841116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1451206 1451206 1375349 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899321 899321 816933 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2479707 2479707 2342453 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891211 1891211 1780580 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453430 1453430 1377463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990901 1990901 1876236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914809 914809 832258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103631 1103631 1017883 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166438 1166438 1078752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 77 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2479706 2479706 2342452 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875379 1875379 1765962 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891201 1891201 1780570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226867 2226867 2094602 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1242316 1242316 1154046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19671738 surgery-fixed primary 56 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895123 1895123 1783815 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875798 1875798 1766381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005359 1005359 922571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 44 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450929 1450929 1375072 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 84 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042915 1042915 959256 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2672955 2672955 2532453 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM34166 178380439 c.? p.R108K Substitution - Missense + - Reported in another cancer sample as somatic 26191234 surgery-fixed primary ENSP00000275493.2:p.Arg108Lys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668542 1668542 1581835 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899325 899325 816937 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005363 1005363 922575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 50 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602820 1602820 1522156 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594594 1594594 1515562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 907088 907088 824600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983739 1983739 1869975 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PC-3 946056 862582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982785 982785 898504 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AP-A0LM-01 1783352 1687351 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51797307 COSM1090871 132567606 c.1175C>A p.S392Y Substitution - Missense het 38 7:55160150-55160150 + - PATHOGENIC .98943 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 33 ENSP00000395243.3:p.Ser392Tyr ENST00000454757.6:c.1175C>A 7:g.55160150C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 HCC4006 2776305 2634441 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51830861 COSM6219 132551512 c.2113G>C p.A705P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Reported in another cancer sample as somatic 29681454 NS NS ENSP00000395243.3:p.Ala705Pro ENST00000454757.6:c.2113G>C 7:g.55174785G>C EGFR ENST00000275493.6 3633 3236 2538747 2538747 2400385 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51785733 COSM28575 99408096 c.2650G>A p.E884K Substitution - Missense 38 7:55192790-55192790 + - PATHOGENIC .9655 Reported in another cancer sample as somatic 27425854 surgery - NOS secondary 59 ENSP00000275493.2:p.Glu884Lys ENST00000275493.6:c.2650G>A 7:g.55192790G>A EGFR ENST00000275493.6 3633 3236 1998742 1998742 1883814 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23937608 surgery-fixed primary 63 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1892630 1892630 1781882 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23579627 surgery - NOS recurrent 43 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345115 2345115 2209787 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1694974 1694974 1603194 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 47 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875341 1875341 1765924 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1593012 1593012 1513938 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1500176 1500176 1423055 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450937 1450937 1375080 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 61 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1107245 1107245 1021157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1451639 1451639 1375782 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855820 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1877000 1877000 1767562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2651873 2651873 2512013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27257132 surgery - NOS recurrent 71 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1672450 1672450 1585504 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21729655 surgery-fixed primary 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983819 1983819 1870055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895071 1895071 1783763 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1990896 1990896 1876231 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450931 1450931 1375074 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1631939 1631939 1548809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895138 1895138 1783830 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450860 1450860 1375003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1593016 1593016 1513942 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899308 899308 816920 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1110464 1110464 1024342 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2659764 2659764 2519922 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51799041 COSM52931 99408351 c.2195T>C p.I732T Substitution - Missense 38 7:55174732-55174732 + - PATHOGENIC .98814 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Ile732Thr ENST00000275493.6:c.2195T>C 7:g.55174732T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592990 1592990 1513916 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895068 1895068 1783760 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-67-3770-01 1780199 1684198 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895126 1895126 1783818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372543 2372543 2235336 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226864 2226864 2094599 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891285 1891285 1780654 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077346 1077346 992600 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1047002 1047002 963233 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089142 1089142 1004096 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 20 1433985 1343400 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372597 2372597 2235390 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302283 1302283 1213334 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891268 1891268 1780637 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1197365 1197365 1109260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862710 2862710 2717873 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983754 1983754 1869990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895115 1895115 1783807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067062 1067062 983042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631945 1631945 1548815 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1451207 1451207 1375350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043871 1043871 960212 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1576787 1576787 1498228 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 65 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1522942 1522942 1445314 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 56 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1992084 1992084 1877401 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 84 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1024758 1024758 941735 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 surgery fresh/frozen metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879548 1879548 1770050 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980065 1980065 1866308 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 75 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226915 2226915 2094650 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2579341 2579341 2440678 NS NS NS NS malignant_melanoma NS NS NS n COSV51770777 COSM28286 132563968 c.2359C>T p.R787C Substitution - Missense 38 7:55191743-55191743 + - PATHOGENIC .95135 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000395243.3:p.Arg787Cys ENST00000454757.6:c.2359C>T 7:g.55191743C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602810 1602810 1522146 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2757126 2757126 2615769 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 29858019 circulating tumour recurrent 50 ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1000059 1000059 917282 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1876995 1876995 1767557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875362 1875362 1765945 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231315 1231315 1143105 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1451205 1451205 1375348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875342 1875342 1765925 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LK-2 946071 862597 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891293 1891293 1780662 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1789304 1789304 1692708 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2878946 2878946 2733461 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 33115932 surgery-fixed NS 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897838 897838 815460 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593015 1593015 1513941 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1541734 1541734 1464038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21469767 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924523 924523 841296 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103759 1103759 1018011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 76 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1881377 1881377 1771528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1168012 1168012 1080254 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009146 2009146 1891880 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1074945 1074945 990199 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 44 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895113 1895113 1783805 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778633 2778633 2636687 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS n COSV51820767 COSM53288 133212022 c.2219C>T p.T740I Substitution - Missense 38 7:55181363-55181363 + - PATHOGENIC .9109 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000415559.1:p.Thr740Ile ENST00000455089.5:c.2219C>T 7:g.55181363C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 10 2570187 2431484 skin face NS NS adnexal_tumour other sebaceoma NS n COSV51768262 COSM26445 133205089 c.2165C>T p.A722V Substitution - Missense 38 7:55181309-55181309 + - PATHOGENIC .97799 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 76 ENSP00000415559.1:p.Ala722Val ENST00000455089.5:c.2165C>T 7:g.55181309C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043133 1043133 959474 upper_aerodigestive_tract tonsil NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51771943 COSM22953 132569426 c.2266T>C p.Y756H Substitution - Missense 38 7:55181410-55181410 + - PATHOGENIC .96426 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 62 ENSP00000395243.3:p.Tyr756His ENST00000454757.6:c.2266T>C 7:g.55181410T>C EGFR ENST00000275493.6 3633 3236 1284744 1284744 1196039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 16467085 surgery-fixed metastasis ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 2046181 2046181 1926476 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-018-tumor 2818983 2675282 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00264T00264 2857327 2712627 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891266 1891266 1780635 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077370 1077370 992624 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1295349 1295349 1206428 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777782 COSM6227 132554599 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 19884551 surgery fresh/frozen NS ENSP00000395243.3:p.His790Leu ENST00000454757.6:c.2369A>T 7:g.55191753A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895147 1895147 1783839 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778531 2778531 2636585 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51775222 COSM13189 132558076 c.2216C>T p.S739F Substitution - Missense 38 7:55181360-55181360 + - PATHOGENIC .94833 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000395243.3:p.Ser739Phe ENST00000454757.6:c.2216C>T 7:g.55181360C>T EGFR ENST00000275493.6 3633 3236 2651873 2651873 2512013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 27257132 surgery - NOS recurrent 71 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1097467 1097467 1012131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 18090579 NS NS 45 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766493 COSM6493937 99388191 c.2389T>A p.C797S Substitution - Missense het 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2389T>A 7:g.55181398T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 411 898398 816010 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1038991 1038991 955568 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1434025 1434025 1343440 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2479713 2479713 2342459 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302282 1302282 1213333 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895135 1895135 1783827 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1627728 1627728 1544640 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983737 1983737 1869973 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450938 1450938 1375081 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 76 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226868 2226868 2094603 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895156 1895156 1783848 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098854 1098854 1013446 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1456559 1456559 1380534 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2878933 2878933 2733448 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 33115932 surgery-fixed NS 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450927 1450927 1375070 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1751713 1751713 1656529 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1038990 1038990 955567 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51832111 COSM6493934 99392455 c.2375T>A p.L792H Substitution - Missense het 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000275493.2:p.Leu792His ENST00000275493.6:c.2375T>A 7:g.55181384T>A EGFR ENST00000275493.6 3633 3236 V43 1179744 1091706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 82 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2009150 2009150 1891884 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1435992 1435992 1345271 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen NS 85 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453415 1453415 1377448 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1860423 1860423 1751364 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1625788 1625788 1543012 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891241 1891241 1780610 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983729 1983729 1869965 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1435975 1435975 1345254 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery-fixed primary 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136895 1136895 1049459 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042906 1042906 959247 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891248 1891248 1780617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891267 1891267 1780636 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1231310 1231310 1143100 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891230 1891230 1780599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136890 1136890 1049454 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231320 1231320 1143110 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983741 1983741 1869977 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891229 1891229 1780598 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895163 1895163 1783855 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-175-tumor 2819068 2675367 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00383T00383 2857375 2712675 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631949 1631949 1548819 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD_E01166 1765174 1669494 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 22980975 surgery - NOS primary ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0002PT00015T00015 2857336 2712636 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 907086 907086 824598 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1107247 1107247 1021159 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2867756 2867756 2722779 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26131 178380442 c.? p.E746V Substitution - Missense + - Reported in another cancer sample as somatic 25345567 surgery-fixed NS ENSP00000275493.2:p.Glu746Val EGFR ENST00000275493.6 3633 3236 1526688 1526688 1449056 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51796850 COSM24846 99415765 c.2491C>T p.R831C Substitution - Missense het 38 7:55191740-55191740 + - PATHOGENIC .9406 Reported in another cancer sample as somatic 21573507 surgery-fixed NS ENSP00000275493.2:p.Arg831Cys ENST00000275493.6:c.2491C>T 7:g.55191740C>T EGFR ENST00000275493.6 3633 3236 BC1-3 2824185 2680012 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51787208 COSM327142 99376659 c.3352G>A p.A1118T Substitution - Missense 38 7:55205336-55205336 + - NEUTRAL .10522 Reported in another cancer sample as somatic 31867841 circulating tumour recurrent 54 ENSP00000275493.2:p.Ala1118Thr ENST00000275493.6:c.3352G>A 7:g.55205336G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2840788 2840788 2696348 prostate NS NS NS carcinoma NS NS NS n COSV51824002 COSM6937752 133229963 c.2659C>T p.R887C Substitution - Missense 38 7:55198809-55198809 + - PATHOGENIC .91422 Reported in another cancer sample as somatic 31874108 surgery-fixed metastasis ENSP00000415559.1:p.Arg887Cys ENST00000455089.5:c.2659C>T 7:g.55198809C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1047008 1047008 963239 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891299 1891299 1780668 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1661392 1661392 1575007 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22483783 surgery-fixed NS 61 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302244 1302244 1213295 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00226T00226 2857365 2712665 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-185-tumor 2819071 2675370 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-087-tumor 2819019 2675318 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875799 1875799 1766382 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-67-6217-01 1780210 1684209 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879497 1879497 1769999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879523 1879523 1770025 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226889 2226889 2094624 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064724 2064724 1944801 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103803 1103803 1018055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479932 1479932 1403592 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226886 2226886 2094621 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594598 1594598 1515566 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1075003 1075003 990257 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 55 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450942 1450942 1375085 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 65 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875793 1875793 1766376 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1434020 1434020 1343435 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005358 1005358 922570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2860650 2860650 2715938 central_nervous_system choroid_plexus NS NS other choroid_plexus_papilloma NS NS n COSV51803731 COSM28604 132550372 c.2371C>T p.R791C Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .95213 Reported in another cancer sample as somatic 31612017 surgery-fixed NS 3 ENSP00000395243.3:p.Arg791Cys ENST00000454757.6:c.2371C>T 7:g.55191755C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879237 1879237 1769792 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23468066 surgery-fixed NS 48 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891335 1891335 1780704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891335 1891335 1780704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592994 1592994 1513920 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675155 2675155 2534429 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766284 COSM28512 132550675 c.2095A>G p.I699V Substitution - Missense 38 7:55174767-55174767 + - PATHOGENIC .99591 Reported in another cancer sample as somatic 29075127 surgery fresh/frozen NS ENSP00000395243.3:p.Ile699Val ENST00000454757.6:c.2095A>G 7:g.55174767A>G EGFR ENST00000275493.6 3633 3236 2785975 2785975 2643435 large_intestine colon ascending NS carcinoma neuroendocrine_carcinoma NS NS n COSV51781835 COSM174732 99379122 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Reported in another cancer sample as somatic 28730258 surgery-fixed primary 61 ENSP00000275493.2:p.Glu114Lys ENST00000275493.6:c.340G>A 7:g.55143404G>A EGFR ENST00000275493.6 3633 3236 1053141 1053141 969212 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM24429 178380423 c.? p.E709G Substitution - Missense + - Reported in another cancer sample as somatic 17409961 surgery - NOS NS 60 ENSP00000275493.2:p.Glu709Gly EGFR ENST00000275493.6 3633 3236 1194725 1194725 1106620 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 99377226 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Ala289Asp ENST00000275493.6:c.866C>A 7:g.55154129C>A EGFR ENST00000275493.6 3633 3236 1031898 1031898 948689 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 17085664 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1542236 1542236 1464539 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21784628 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746664 1746664 1651640 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 63 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1468070 1468070 1391916 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 48 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602795 1602795 1522131 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 2083476 2083476 1961759 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24481316 surgery - NOS primary 45 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027746 2027746 1909649 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027826 2027826 1909729 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2260321 2260321 2127306 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25263855 fine needle aspirate NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2426843 2426843 2289764 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2476838 2476838 2339607 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096299 2096299 1974363 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264419 2264419 2131403 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2096248 2096248 1974312 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1637168 1637168 1553216 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1052973 1052973 969044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17410005 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469399 1469399 1393138 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1312395 1312395 1223304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 19723643 surgery fresh/frozen NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469874 1469874 1393613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1435653 1435653 1344932 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20661086 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008793 2008793 1891527 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141313 1141313 1053761 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000251 2000251 1885149 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469365 1469365 1393104 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1424047 1424047 1334075 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20595147 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637184 1637184 1553232 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118442 2118442 1992677 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637126 1637126 1553174 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444752 1444752 1368995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637227 1637227 1553275 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1517371 1517371 1439755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21610522 surgery fresh/frozen metastasis 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174310 1174310 1086329 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346483 2346483 2211146 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096124 2096124 1974188 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895170 1895170 1783862 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194737 1194737 1106632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1107251 1107251 1021163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2791158 2791158 2648356 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense hom 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 30922580 pleural effusion metastasis 60 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1914950 1914950 1802952 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2349277 2349277 2213669 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25654374 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777345 1777345 1681348 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838651 1838651 1732752 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475397 1475397 1399096 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680716 2680716 2539989 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444798 1444798 1369041 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476907 2476907 2339676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777329 1777329 1681332 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046062 2046062 1926357 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1746664 1746664 1651640 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937512 1937512 1824446 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637208 1637208 1553256 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1931639 1931639 1818929 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345079 2345079 2209751 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1983804 1983804 1870040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1981031 1981031 1867267 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345072 2345072 2209744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1733456 1733456 1639405 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779524 COSM18425 132552477 c.2021G>A p.G674D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Reported in another cancer sample as somatic 22821383 surgery-fixed primary ENSP00000395243.3:p.Gly674Asp ENST00000454757.6:c.2021G>A 7:g.55174015G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-02-0021-01 1910130 1798421 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 132553689 c.619C>T p.R207C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 44 ENSP00000395243.3:p.Arg207Cys ENST00000454757.6:c.619C>T 7:g.55154017C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980073 1980073 1866316 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 69 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-171-tumor 2819064 2675363 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2662907 2662907 2523029 kidney NS NS NS Wilms_tumour NS NS NS n COSV51778029 COSM6268 132554063 c.2122C>T p.P708S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Reported in another cancer sample as somatic 28326956 surgery-fixed NS ENSP00000395243.3:p.Pro708Ser ENST00000454757.6:c.2122C>T 7:g.55174794C>T EGFR ENST00000275493.6 3633 3236 1036627 1036627 953384 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 17201173 NS NS ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 1989947 1989947 1875286 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51789625 COSM13197 99376708 c.2590G>A p.A864T Substitution - Missense hom 38 7:55191839-55191839 + - PATHOGENIC .9615 Reported in another cancer sample as somatic 23585556 surgery-fixed primary ENSP00000275493.2:p.Ala864Thr ENST00000275493.6:c.2590G>A 7:g.55191839G>A EGFR ENST00000275493.6 3633 3236 2095984 2095984 1974048 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014079 1014079 931253 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476889 2476889 2339658 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668435 1668435 1581728 lung left_upper_lobe NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22526156 surgery-fixed primary 18 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1444716 1444716 1368959 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1154303 1154303 1066639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18957054 surgery-fixed NS 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096211 2096211 1974275 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1585333 1585333 1506654 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22011666 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096090 2096090 1974154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422795 2422795 2285717 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264208 2264208 2131192 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770516 1770516 1674756 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476898 2476898 2339667 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422937 2422937 2285859 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1882522 1882522 1772657 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23486266 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148623 2148623 2017753 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264250 2264250 2131234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459510 1459510 1383453 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083476 2083476 1961759 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481316 surgery - NOS primary 45 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551533 1551533 1473638 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008795 2008795 1891529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777271 1777271 1681274 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1047873 1047873 964102 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17228019 surgery - NOS NS 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637107 1637107 1553155 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996947 1996947 1882156 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246677 1246677 1158356 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469456 1469456 1393195 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218531 2218531 2086542 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777252 1777252 1681255 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983102 983102 898820 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887376 1887376 1777048 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770747 1770747 1674987 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2803992 2803992 2660720 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31254668 circulating tumour recurrent 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081815 2081815 1960237 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481317 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329253 1329253 1239738 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451767 1451767 1375816 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20615575 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770687 1770687 1674927 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838681 1838681 1732782 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591017 1591017 1512133 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264321 2264321 2131305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430052 1430052 1339470 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203080 2203080 2071338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1076400 1076400 991654 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17607119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1328028 1328028 1238517 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20307913 surgery - NOS primary 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1107780 1107780 1021683 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1202167 1202167 1114053 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19371962 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081935 2081935 1960357 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24440279 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076955 2076955 1955704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed NS 49 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2819302 2819302 2675601 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 30711944 pleural effusion recurrent 64 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778773 2778773 2636827 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1024768 1024768 941745 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659764 2659764 2519922 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51799041 COSM52931 132576030 c.2060T>C p.I687T Substitution - Missense 38 7:55174732-55174732 + - PATHOGENIC .98814 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Ile687Thr ENST00000454757.6:c.2060T>C 7:g.55174732T>C EGFR ENST00000275493.6 3633 3236 2026239 2026239 1908328 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51793933 COSM250050 99444781 c.2570G>A p.G857E Substitution - Missense het 38 7:55191819-55191819 + - PATHOGENIC .98882 Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Gly857Glu ENST00000275493.6:c.2570G>A 7:g.55191819G>A EGFR ENST00000275493.6 3633 3236 2046049 2046049 1926344 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345435 2345435 2210107 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430048 1430048 1339466 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542354 1542354 1464657 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469438 1469438 1393177 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777289 1777289 1681292 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226146 2226146 2093881 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937546 1937546 1824480 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142064 2142064 2011282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237682 1237682 1149429 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549146 2549146 2410601 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1284670 1284670 1195965 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16467085 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1047973 1047973 964201 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17337084 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862108 2862108 2717310 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51841095 COSM133588 133224594 c.2135A>G p.K712R Substitution - Missense 38 7:55174807-55174807 + - PATHOGENIC .9946 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000415559.1:p.Lys712Arg ENST00000455089.5:c.2135A>G 7:g.55174807A>G EGFR ENST00000275493.6 3633 3236 1052974 1052974 969045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17410005 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1610401 1610401 1529641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22142557 pleural effusion NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096299 2096299 1974363 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960188 1960188 1846828 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-17-G34953 2905427 2759683 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51788796 COSM4680390 132569555 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000395243.3:p.Arg98Gln ENST00000454757.6:c.293G>A 7:g.55143357G>A EGFR ENST00000275493.6 3633 3236 2240677 2240677 2108208 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 64 ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 1998742 1998742 1883814 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 23937608 surgery-fixed primary 63 ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 1530969 1530969 1453341 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2538747 2538747 2400385 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51785733 COSM28575 132575807 c.2515G>A p.E839K Substitution - Missense 38 7:55192790-55192790 + - PATHOGENIC .9655 Reported in another cancer sample as somatic 27425854 surgery - NOS secondary 59 ENSP00000395243.3:p.Glu839Lys ENST00000454757.6:c.2515G>A 7:g.55192790G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2651873 2651873 2512013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27257132 surgery - NOS recurrent 71 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1877000 1877000 1767562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450931 1450931 1375074 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593016 1593016 1513942 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1500176 1500176 1423055 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895071 1895071 1783763 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1672450 1672450 1585504 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21729655 surgery-fixed primary 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1107245 1107245 1021157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450937 1450937 1375080 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 61 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593012 1593012 1513938 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631939 1631939 1548809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990896 1990896 1876231 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899308 899308 816920 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450860 1450860 1375003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110464 1110464 1024342 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879513 1879513 1770015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1980064 1980064 1866307 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 67 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2147905 2147905 2017048 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 45 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1451639 1451639 1375782 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855820 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875341 1875341 1765924 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983819 1983819 1870055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924345 924345 841120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042919 1042919 959260 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983717 1983717 1869953 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098872 1098872 1013464 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1046994 1046994 963225 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983731 1983731 1869967 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372593 2372593 2235386 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226884 2226884 2094619 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891332 1891332 1780701 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983768 1983768 1870004 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891207 1891207 1780576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429327 1429327 1338778 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891212 1891212 1780581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875372 1875372 1765955 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1573771 1573771 1495240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21982684 surgery fresh/frozen metastasis 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891287 1891287 1780656 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372588 2372588 2235381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875375 1875375 1765958 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899307 899307 816919 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098860 1098860 1013452 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0154-01 1910182 1798473 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense hom 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 55 ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 OX-CO-2_R3_Cetux 2841378 2696927 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 99390660 c.1391C>T p.S464L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000275493.2:p.Ser464Leu ENST00000275493.6:c.1391C>T 7:g.55160231C>T EGFR ENST00000275493.6 3633 3236 2579398 2579398 2440735 NS NS NS NS malignant_melanoma NS NS NS n COSV51788796 COSM4680390 99401501 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000275493.2:p.Arg98Gln ENST00000275493.6:c.293G>A 7:g.55143357G>A EGFR ENST00000275493.6 3633 3236 2046184 2046184 1926479 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1965926 1965926 1852419 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032241 2032241 1913712 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481245 1481245 1404874 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1667694 1667694 1580987 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481234 1481234 1404863 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1547770 1547770 1469892 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 58 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746671 1746671 1651647 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 64 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1444573 1444573 1368818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 20686428 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2136615 2136615 2006166 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS 64 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1965916 1965916 1852409 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096300 2096300 1974364 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2153111 2153111 2022121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631937 1631937 1548807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1135554 1135554 1048118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 18676761 NS NS 80 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618673 1618673 1537425 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 69 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618710 1618710 1537462 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 85 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2675682 2675682 2534956 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29100434 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032214 2032214 1913685 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1892630 1892630 1781882 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 23579627 surgery - NOS recurrent 43 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618781 1618781 1537533 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 77 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2680611 2680611 2539884 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 35 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469856 1469856 1393595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2637640 2637640 2498013 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 54 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027730 2027730 1909633 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1651679 1651679 1566466 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22420950 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422840 2422840 2285762 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1585319 1585319 1506640 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22011666 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2637646 2637646 2498019 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 61 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1279081 1279081 1190377 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed metastasis 74 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1547790 1547790 1469912 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 pleural effusion recurrent 85 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1451632 1451632 1375775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 20855820 surgery - NOS NS ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1113005 1113005 1026511 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 18302229 surgery - NOS NS 64 ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1318769 1318769 1229667 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773049 COSM22943 132549396 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 19955396 surgery fresh/frozen NS ENSP00000395243.3:p.Pro803Leu ENST00000454757.6:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-NYU696 1765167 1669487 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 57 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2345124 2345124 2209796 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1705532 1705532 1613438 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2345517 2345517 2210189 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237671 1237671 1149418 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046031 2046031 1926326 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914962 1914962 1802964 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1624151 1624151 1541738 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22000696 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148585 2148585 2017715 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887428 1887428 1777100 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842970 1842970 1736218 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345454 2345454 2210126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637149 1637149 1553197 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2432451 2432451 2295352 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25798276 NS NS 96 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029012 2029012 1910894 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937555 1937555 1824489 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960191 1960191 1846831 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887367 1887367 1777039 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106558 2106558 1984421 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106544 2106544 1984407 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2605903 2605903 2466865 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28271038 surgery - NOS metastasis 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770602 1770602 1674842 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770540 1770540 1674780 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141297 1141297 1053745 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770528 1770528 1674768 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2579649 2579649 2440986 NS NS NS NS malignant_melanoma NS NS NS n COSV51781835 COSM174732 133207258 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000415559.1:p.Glu114Lys ENST00000455089.5:c.340G>A 7:g.55143404G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-16-G44694 2905057 2759313 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983748 1983748 1869984 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2000239 2000239 1885137 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174328 1174328 1086347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1795776 1795776 1697524 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23110940 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2675161 2675161 2534435 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766268 COSM13183 99377562 c.2225T>C p.V742A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Reported in another cancer sample as somatic 29075127 surgery fresh/frozen NS ENSP00000275493.2:p.Val742Ala ENST00000275493.6:c.2225T>C 7:g.55174762T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-B5-A0JZ-01 1783389 1687388 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51823220 COSM13179 133214404 c.1945C>T p.P649S Substitution - Missense hom 38 7:55173939-55173939 + - PATHOGENIC .97389 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 60 ENSP00000415559.1:p.Pro649Ser ENST00000455089.5:c.1945C>T 7:g.55173939C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00240T00240 2857369 2712669 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-083-tumor 2819016 2675315 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-168-tumor 2819062 2675361 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983709 1983709 1869945 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043131 1043131 959472 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51789261 COSM12986 132561937 c.2294G>A p.G765D Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98244 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 49 ENSP00000395243.3:p.Gly765Asp ENST00000454757.6:c.2294G>A 7:g.55181438G>A EGFR ENST00000275493.6 3633 3236 2422928 2422928 2285850 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2686021 2686021 2545056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965926 1965926 1852419 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174322 1174322 1086341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838714 1838714 1732815 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237678 1237678 1149425 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1675620 1675620 1588500 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22560922 surgery-fixed metastasis 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770677 1770677 1674917 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638772 1638772 1554771 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1162988 1162988 1075311 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18992959 NS primary 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2078472 2078472 1957191 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777423 1777423 1681426 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2078474 2078474 1957193 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1196947 1196947 1108842 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965921 1965921 1852414 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937582 1937582 1824516 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179106 1179106 1091068 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19185949 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345371 2345371 2210043 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587269 1587269 1508440 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345496 2345496 2210168 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1897796 1897796 1786480 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23555954 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2156967 2156967 2025942 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838639 1838639 1732740 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667694 1667694 1580987 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1795767 1795767 1697515 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23110940 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2562081 2562081 2423477 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625578 2625578 2485990 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 74 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1838552 1838552 1732653 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844343 1844343 1737377 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1489666 1489666 1412824 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21155184 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290950 2290950 2157015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921910 1921910 1809228 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264121 2264121 2131105 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118431 2118431 1992666 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459511 1459511 1383454 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774686 1774686 1678910 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS metastasis 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226185 2226185 2093920 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2686014 2686014 2545049 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469464 1469464 1393203 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551539 1551539 1473644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246635 1246635 1158314 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444573 1444573 1368818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20686428 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237673 1237673 1149420 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047767 2047767 1928039 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141325 1141325 1053773 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983121 983121 898839 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1074915 1074915 990169 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17508947 surgery fresh/frozen primary 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618748 1618748 1537500 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638764 1638764 1554763 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937575 1937575 1824509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444740 1444740 1368983 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469392 1469392 1393131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469371 1469371 1393110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345580 2345580 2210252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096300 2096300 1974364 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770729 1770729 1674969 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226142 2226142 2093877 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096040 2096040 1974104 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2785996 2785996 2643453 large_intestine colon right NS carcinoma neuroendocrine_carcinoma NS NS n COSV51787507 COSM13188 133213942 c.2146G>A p.D716N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 27586204 NS NS 72 ENSP00000415559.1:p.Asp716Asn ENST00000455089.5:c.2146G>A 7:g.55174818G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 B00426 2910515 2764377 ovary NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51792433 COSM6966446 132577379 c.1627G>A p.G543S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Reported in another cancer sample as somatic 33947352 surgery-fixed NS ENSP00000395243.3:p.Gly543Ser ENST00000454757.6:c.1627G>A 7:g.55165319G>A EGFR ENST00000275493.6 3633 3236 2096241 2096241 1974305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2264418 2264418 2131402 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 23 2570184 2431481 skin forearm NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51767182 COSM27110 99381953 c.2356G>A p.V786M Substitution - Missense 38 7:55181365-55181365 + - PATHOGENIC .97319 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 67 ENSP00000275493.2:p.Val786Met ENST00000275493.6:c.2356G>A 7:g.55181365G>A EGFR ENST00000275493.6 3633 3236 2148004 2148004 2017147 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24707260 surgery - NOS primary 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1752341 1752341 1657152 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22912354 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2729132 2729132 2587943 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29368620 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046056 2046056 1926351 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264264 2264264 2131248 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921889 1921889 1809207 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1939332 1939332 1826256 small_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23644682 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444785 1444785 1369028 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096178 2096178 1974242 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237690 1237690 1149437 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618880 1618880 1537632 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083808 1083808 998973 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329254 1329254 1239739 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637256 1637256 1553304 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1026386 1026386 943362 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17047648 surgery-fixed primary 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1135554 1135554 1048118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18676761 NS NS 80 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1355105 1355105 1265200 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618710 1618710 1537462 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 85 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429297 1429297 1338748 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1196037 1196037 1107932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19272767 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345491 2345491 2210163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046067 2046067 1926362 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2271426 2271426 2138058 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25257380 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264278 2264278 2131262 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551553 1551553 1473658 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680487 2680487 2539760 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1892630 1892630 1781882 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23579627 surgery - NOS recurrent 43 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096103 2096103 1974167 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996549 1996549 1881758 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23922984 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173397 1173397 1085481 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637182 1637182 1553230 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425710 2425710 2288631 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1837421 1837421 1731620 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23242437 NS NS 81 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264328 2264328 2131312 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000149 2000149 1885047 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770742 1770742 1674982 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2439550 2439550 2302390 lung NS NS NS carcinoma invasive_mucinous_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24119562 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618781 1618781 1537533 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083800 1083800 998965 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096208 2096208 1974272 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542146 1542146 1464449 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874750 1874750 1765341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2757341 2757341 2615978 lung right NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28274743 surgery - NOS NS 41 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469856 1469856 1393595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476879 2476879 2339648 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279045 1279045 1190341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed metastasis 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591018 1591018 1512134 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2803990 2803990 2660718 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31254668 surgery - NOS primary 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2141449 2141449 2010667 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24636848 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770609 1770609 1674849 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345587 2345587 2210259 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2015360 2015360 1897568 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23963360 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148619 2148619 2017749 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1651679 1651679 1566466 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22420950 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402527 2402527 2265383 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345402 2345402 2210074 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2069199 2069199 1948774 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24346091 NS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345549 2345549 2210221 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1856198 1856198 1748751 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637157 1637157 1553205 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542153 1542153 1464456 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422840 2422840 2285762 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345461 2345461 2210133 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777350 1777350 1681353 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2675407 2675407 2534681 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891336 1891336 1780705 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1576781 1576781 1498222 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 77 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980068 1980068 1866311 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 72 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980066 1980066 1866309 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 56 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2432377 2432377 2295280 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 26473643 surgery fresh/frozen metastasis 53 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1522946 1522946 1445318 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 56 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2142115 2142115 2011333 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2110152 2110152 1986504 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24563335 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777303 1777303 1681306 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838544 1838544 1732645 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914917 1914917 1802919 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174309 1174309 1086328 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096168 2096168 1974232 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000247 2000247 1885145 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881375 1881375 1771526 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1981027 1981027 1867263 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042901 1042901 959242 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1110466 1110466 1024344 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1067041 1067041 983021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1031899 1031899 948690 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17085664 NS recurrent ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1668523 1668523 1581816 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1162207 1162207 1074539 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983778 1983778 1870014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1517071 1517071 1439665 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895112 1895112 1783804 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1789317 1789317 1692721 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1593013 1593013 1513939 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2616331 2616331 2476817 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26118982 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592995 1592995 1513921 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2479708 2479708 2342454 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1694973 1694973 1603193 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226915 2226915 2094650 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777782 COSM6227 132554599 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.His790Leu ENST00000454757.6:c.2369A>T 7:g.55191753A>T EGFR ENST00000275493.6 3633 3236 1450932 1450932 1375075 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 56 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LUAD-F00134 1765150 1669470 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 87 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982785 982785 898504 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2035481 2035481 1916843 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24034463 pleural effusion recurrent 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302272 1302272 1213323 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 11-18-GEF10-1 1731375 1637341 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22815900 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2402749 2402749 2265602 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 26267891 surgery-fixed primary 42 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 RPC-9 1083085 998250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17699786 cell-line NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778776 2778776 2636830 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2147905 2147905 2017048 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 45 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862714 2862714 2717877 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 132565801 c.2146G>T p.D716Y Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99554 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Asp716Tyr ENST00000454757.6:c.2146G>T 7:g.55174818G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862714 2862714 2717877 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1697982 1697982 1606100 salivary_gland NS NS NS carcinoma acinic_cell_carcinoma NS NS n COSV51773049 COSM22943 132549396 c.2408C>T p.P803L Substitution - Missense het 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 22694907 surgery-fixed NS ENSP00000395243.3:p.Pro803Leu ENST00000454757.6:c.2408C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 1879551 1879551 1770053 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1980070 1980070 1866313 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 64 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2659762 2659762 2519920 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2035481 2035481 1916843 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 24034463 pleural effusion recurrent 74 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-GE026-T1 2869747 2724744 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51789362 COSM13184 133232364 c.2101G>A p.E701K Substitution - Missense 38 7:55174773-55174773 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 26950094 surgery - NOS NS 74 ENSP00000415559.1:p.Glu701Lys ENST00000455089.5:c.2101G>A 7:g.55174773G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891305 1891305 1780674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-GE101-T1 2869805 2724802 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51822498 COSM3266565 133238887 c.782C>T p.S261L Substitution - Missense 38 7:55155857-55155857 + - PATHOGENIC .98807 Reported in another cancer sample as somatic 26950094 surgery - NOS NS 81 ENSP00000415559.1:p.Ser261Leu ENST00000455089.5:c.782C>T 7:g.55155857C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625627 2625627 2486039 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51767687 COSM6191352 133202248 c.1612G>A p.A538T Substitution - Missense het 38 7:55165304-55165304 + - PATHOGENIC .98656 Reported in another cancer sample as somatic 26488212 surgery-fixed NS ENSP00000415559.1:p.Ala538Thr ENST00000455089.5:c.1612G>A 7:g.55165304G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1789304 1789304 1692708 lung NS NS NS carcinoma NS NS NS n COSV51765252 COSM13009 133225791 c.1991A>G p.E664G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000415559.1:p.Glu664Gly ENST00000455089.5:c.1991A>G 7:g.55173985A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2676600 2676600 2535874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766331 COSM12366 132582479 c.2437C>A p.L813M Substitution - Missense 38 7:55191821-55191821 + - PATHOGENIC .93782 Reported in another cancer sample as somatic 28939152 NS NS 35 ENSP00000395243.3:p.Leu813Met ENST00000454757.6:c.2437C>A 7:g.55191821C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-066-tumor 2819004 2675303 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226869 2226869 2094604 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897804 897804 815426 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008349-T01-IM5 2724478 2583299 haematopoietic_and_lymphoid_tissue lymph_node NS NS lymphoid_neoplasm angioimmunoblastic_T_cell_lymphoma NS NS n COSV51806667 COSM6987130 132569004 c.1804G>A p.A602T Substitution - Missense het 38 7:55173002-55173002 + - PATHOGENIC .99609 Reported in another cancer sample as somatic 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala602Thr ENST00000454757.6:c.1804G>A 7:g.55173002G>A EGFR ENST00000275493.6 3633 3236 1107791 1107791 1021694 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1465904 1465904 1389751 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 75 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2136624 2136624 2006175 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1459531 1459531 1383474 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1551502 1551502 1473607 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345050 2345050 2209722 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5330 915979 833378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773111 COSM13185 133203473 c.2117C>T p.T706I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000415559.1:p.Thr706Ile ENST00000455089.5:c.2117C>T 7:g.55174789C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891337 1891337 1780706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879562 1879562 1770064 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1576785 1576785 1498226 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 60 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042858 1042858 959199 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1113004 1113004 1026511 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 18302229 surgery - NOS NS 64 ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879483 1879483 1769985 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1894921 1894921 1783613 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042856 1042856 959197 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1894920 1894920 1783612 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AS-3778-01 1779806 1683805 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51831642 COSM1496684 132560351 c.853G>A p.E285K Substitution - Missense 38 7:55155928-55155928 + - PATHOGENIC .94538 Reported in another cancer sample as somatic 416 fresh/frozen - NOS primary 35 ENSP00000395243.3:p.Glu285Lys ENST00000454757.6:c.853G>A 7:g.55155928G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1235138 1235138 1146924 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 53 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103803 1103803 1018055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1312892 1312892 1223801 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19884861 blood-bone marrow NS 70 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 4C 2529060 2390916 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1135564 1135564 1048128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 18676761 NS NS 66 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2617728 2617728 2478214 lung right NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 26483048 surgery - NOS NS 64 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525683 2525683 2387872 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 ascites recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481241 1481241 1404870 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1986225 1986225 1872461 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481247 1481247 1404876 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2228281 2228281 2096008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2026231 2026231 1908320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2009153 2009153 1891887 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1990905 1990905 1876240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1429292 1429292 1338743 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1429329 1429329 1338780 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1310479 1310479 1221424 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042910 1042910 959251 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450921 1450921 1375064 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 81 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S001095 1027691 944667 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891323 1891323 1780692 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879559 1879559 1770061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980072 1980072 1866315 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 71 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602797 1602797 1522133 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602814 1602814 1522150 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983823 1983823 1870059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891269 1891269 1780638 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345488 2345488 2210160 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2675412 2675412 2534686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2729131 2729131 2587942 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29368620 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095957 2095957 1974021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1196951 1196951 1108846 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914923 1914923 1802925 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 HCC4011-GR-high 1896433 1785120 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23542356 cell-line NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469494 1469494 1393233 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2057474 2057474 1937682 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24236184 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887432 1887432 1777104 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011188 2011188 1893826 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1029022 1029022 945893 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17075123 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421170 2421170 2284092 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885179 1885179 1775066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148506 2148506 2017636 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2675402 2675402 2534676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1235131 1235131 1146917 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19589612 surgery - NOS recurrent 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2260325 2260325 2127310 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25263855 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264320 2264320 2131304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148599 2148599 2017729 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1135564 1135564 1048128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18676761 NS NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770550 1770550 1674790 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618834 1618834 1537586 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336868 1336868 1247253 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937543 1937543 1824477 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2617728 2617728 2478214 lung right NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26483048 surgery - NOS NS 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2562084 2562084 2423480 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014313 1014313 931487 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 924452 924452 841227 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense hom + - Reported in another cancer sample as somatic 16198442 surgery - NOS recurrent 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1052975 1052975 969046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17410005 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1530969 1530969 1453341 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937521 1937521 1824455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290946 2290946 2157011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475393 1475393 1399092 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2078476 2078476 1957195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264262 2264262 2131246 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770653 1770653 1674893 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525683 2525683 2387872 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 ascites recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887394 1887394 1777066 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1823875 1823875 1722269 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23212424 surgery-fixed primary 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842976 1842976 1736224 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2864794 2864794 2719921 lung left_lower_lobe NS NS carcinoma enteric_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28953659 surgery - NOS primary 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469487 1469487 1393226 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246657 1246657 1158336 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141294 1141294 1053742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1661371 1661371 1574986 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22483783 surgery-fixed NS 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336417 1336417 1246802 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20430469 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493337 1493337 1416327 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914897 1914897 1802899 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705465 1705465 1613371 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914955 1914955 1802957 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264224 2264224 2131208 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430043 1430043 1339461 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 3114-ca 2823139 2678993 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28818608 surgery-fixed NS 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278190 1278190 1189488 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246718 1246718 1158397 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838687 1838687 1732788 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522882 1522882 1445254 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770710 1770710 1674950 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095956 2095956 1974020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1110731 1110731 1024609 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18325048 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095905 2095905 1973969 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2136670 2136670 2006221 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838669 1838669 1732770 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1696879 1696879 1605007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22674612 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591055 1591055 1512171 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983106 983106 898824 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1093062 1093062 1007776 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18021415 surgery-fixed primary 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2078478 2078478 1957197 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887380 1887380 1777052 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083816 1083816 998981 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444755 1444755 1368998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226910 2226910 2094645 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PC-7 946057 862583 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239169 2239169 2106701 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 132551401 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 48 ENSP00000395243.3:p.Arg731His ENST00000454757.6:c.2192G>A 7:g.55181336G>A EGFR ENST00000275493.6 3633 3236 1592976 1592976 1513902 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51792805 COSM13005 99375713 c.2318A>T p.H773L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.His773Leu ENST00000275493.6:c.2318A>T 7:g.55181327A>T EGFR ENST00000275493.6 3633 3236 1637170 1637170 1553218 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680584 2680584 2539857 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 36 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770593 1770593 1674833 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914961 1914961 1802963 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345439 2345439 2210111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899355 899355 816967 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302271 1302271 1213322 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077337 1077337 992591 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895131 1895131 1783823 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136875 1136875 1049439 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1188172 1188172 1100071 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19253367 surgery-fixed primary 77 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302275 1302275 1213326 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372778 2372778 2235571 pleura NS NS NS mesothelioma NS NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24569782 surgery-fixed NS 85 ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 2675161 2675161 2534435 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766284 COSM28512 99377567 c.2230A>G p.I744V Substitution - Missense 38 7:55174767-55174767 + - PATHOGENIC .99591 Reported in another cancer sample as somatic 29075127 surgery fresh/frozen NS ENSP00000275493.2:p.Ile744Val ENST00000275493.6:c.2230A>G 7:g.55174767A>G EGFR ENST00000275493.6 3633 3236 1575146 1575146 1496587 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1295828 1295828 1206900 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19640859 fine needle aspirate primary 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1074947 1074947 990201 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 45 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2076208 2076208 1955020 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24406864 surgery-fixed primary 27 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1089597 1089597 1004544 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1751706 1751706 1656522 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-49-4490-01 1780137 1684136 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 45 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924336 924336 841111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1001552 1001552 918775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15851406 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1668459 1668459 1581752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2009151 2009151 1891885 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 16 1433981 1343396 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1109733 1109733 1023643 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18372921 surgery-fixed primary 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593017 1593017 1513943 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450873 1450873 1375016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1047006 1047006 963237 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 H1975 2776253 2634389 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29681454 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891234 1891234 1780603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875797 1875797 1766380 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899346 899346 816958 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668456 1668456 1581749 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1047004 1047004 963235 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990910 1990910 1876245 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983693 1983693 1869929 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009158 2009158 1891892 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1200919 1200919 1112809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1090039 1090039 1004986 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17945377 surgery - NOS NS 32 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453493 1453493 1377526 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897843 897843 815465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450877 1450877 1375020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 49 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453496 1453496 1377529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895083 1895083 1783775 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2078360 2078360 1957079 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24314215 pleural effusion NS 49 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1077334 1077334 992588 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1047000 1047000 963231 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1200918 1200918 1112808 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1541741 1541741 1464045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21469767 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1000056 1000056 917279 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895160 1895160 1783852 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1103633 1103633 1017885 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1200917 1200917 1112807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1931642 1931642 1818932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983704 1983704 1869940 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1479954 1479954 1403614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1876989 1876989 1767551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602801 1602801 1522137 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226767 2226767 2094502 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2667835 2667835 2527497 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1169669 178386037 c.? p.T263P Substitution - Missense + - Reported in another cancer sample as somatic 28663030 surgery-fixed primary ENSP00000275493.2:p.Thr263Pro EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DCR10 1690659 1598936 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 132560744 c.1341C>A p.S447R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000395243.3:p.Ser447Arg ENST00000454757.6:c.1341C>A 7:g.55160316C>A EGFR ENST00000275493.6 3633 3236 1285229 1285229 1196509 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM34167 178379046 c.? p.G598V Substitution - Missense hom + - Reported in another cancer sample as somatic 19789313 surgery - NOS NS ENSP00000275493.2:p.Gly598Val EGFR ENST00000275493.6 3633 3236 2046183 2046183 1926478 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 TCGA-06-0125-01 1910168 1798459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 64 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-014-tumor 2818981 2675280 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879575 1879575 1770077 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1816950 1816950 1716118 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1576784 1576784 1498225 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 surgery - NOS primary 60 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980080 1980080 1866323 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 43 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879574 1879574 1770076 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1074946 1074946 990200 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983779 1983779 1870015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098874 1098874 1013466 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166447 1166447 1078761 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 77 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2734489 2734489 2593198 pancreas NS NS NS other solid_pseudopapillary_neoplasm NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 29695402 surgery-fixed primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2815054 2815054 2671442 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM7002300 178386939 c.? p.C797G Substitution - Missense + Yes Reported in another cancer sample as somatic 29807405 surgery - NOS metastasis 59 ENSP00000275493.2:p.Cys797Gly EGFR ENST00000275493.6 3633 3236 946819 946819 863342 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51803771 COSM14068 99392333 c.2308G>A p.D770N Substitution - Missense 38 7:55181317-55181317 + - PATHOGENIC .97623 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000275493.2:p.Asp770Asn ENST00000275493.6:c.2308G>A 7:g.55181317G>A EGFR ENST00000275493.6 3633 3236 2277163 2277163 2143695 lung right NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24362878 surgery-fixed NS 67 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1656137 1656137 1570794 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21311943 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51832101 COSM6493933 132563558 c.2239C>T p.L747F Substitution - Missense het 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000395243.3:p.Leu747Phe ENST00000454757.6:c.2239C>T 7:g.55181383C>T EGFR ENST00000275493.6 3633 3236 HCC827R1 1890455 1779877 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22773810 cell-line NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1162983 1162983 1075306 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 18992959 NS recurrent 57 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032216 2032216 1913687 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2153173 2153173 2022183 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2664346 2664346 2524416 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 50 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1856349 1856349 1748902 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1075437 1075437 990691 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 17577030 fixed - NOS metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1731090 1731090 1637061 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22815900 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2823657 2823657 2679510 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 31157314 circulating tumour recurrent 73 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618770 1618770 1537522 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22215752 surgery-fixed NS 47 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1610400 1610400 1529640 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22142557 pleural effusion NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2476870 2476870 2339639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481239 1481239 1404868 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 T1751 2823156 2679009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28818608 surgery-fixed NS 65 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1468084 1468084 1391930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 93 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 G73 1179731 1091693 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51780730 COSM22940 99378223 c.2327G>A p.R776H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 58 ENSP00000275493.2:p.Arg776His ENST00000275493.6:c.2327G>A 7:g.55181336G>A EGFR ENST00000275493.6 3633 3236 2595736 2595736 2456612 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS 57 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2476910 2476910 2339679 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2027801 2027801 1909704 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1162983 1162983 1075306 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18992959 NS recurrent 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838725 1838725 1732826 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551563 1551563 1473668 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476871 2476871 2339640 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838667 1838667 1732768 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838728 1838728 1732829 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965841 1965841 1852334 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899356 899356 816968 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766618 COSM12374 132551897 c.2447T>G p.L816R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu816Arg ENST00000454757.6:c.2447T>G 7:g.55191831T>G EGFR ENST00000275493.6 3633 3236 1587273 1587273 1508444 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000265 2000265 1885163 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921917 1921917 1809235 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914911 1914911 1802913 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1896946 1896946 1785633 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23542356 surgery-fixed recurrent 49 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475387 1475387 1399086 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014268 1014268 931442 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1892635 1892635 1781887 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23566546 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1514597 1514597 1437207 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21558399 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1707029 1707029 1614935 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22695392 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279058 1279058 1190354 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed primary 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638777 1638777 1554776 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025392 2025392 1907481 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983108 983108 898826 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551547 1551547 1473652 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345576 2345576 2210248 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2032064 2032064 1913535 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24103528 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1732974 1732974 1638923 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22833420 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264118 2264118 2131102 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862064 2862064 2717271 lung NS NS NS carcinoma fetal_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25851923 surgery-fixed NS 85 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264302 2264302 2131286 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637215 1637215 1553263 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2033584 2033584 1915033 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24137397 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966250 1966250 1852743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23800712 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026247 2026247 1908336 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218522 2218522 2086533 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095968 2095968 1974032 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2855928 2855928 2711331 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24482415 surgery - NOS NS 80 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1856650 1856650 1749202 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23334261 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937531 1937531 1824465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246653 1246653 1158332 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2260329 2260329 2127314 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25263855 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264356 2264356 2131340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705466 1705466 1613372 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1668663 1668663 1581955 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22523351 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118423 2118423 1992658 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1531001 1531001 1453373 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279038 1279038 1190334 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed primary 48 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246671 1246671 1158350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345447 2345447 2210119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960182 1960182 1846822 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469420 1469420 1393159 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064710 2064710 1944787 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345521 2345521 2210193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2823657 2823657 2679510 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31157314 circulating tumour recurrent 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468878 1468878 1392617 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21128242 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618770 1618770 1537522 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 47 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844512 1844512 1737546 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23154768 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770723 1770723 1674963 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141321 1141321 1053769 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025410 2025410 1907499 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637114 1637114 1553162 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770579 1770579 1674819 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045989 2045989 1926284 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025412 2025412 1907501 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173399 1173399 1085483 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476870 2476870 2339639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226870 2226870 2094605 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862118 2862118 2717320 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1173398 1173398 1085482 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425765 2425765 2288686 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476910 2476910 2339679 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638737 1638737 1554736 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734098 1734098 1640047 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22842370 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937526 1937526 1824460 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174296 1174296 1086315 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986172 1986172 1872408 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885168 1885168 1775055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914949 1914949 1802951 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469499 1469499 1393238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1053142 1053142 969213 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17409961 surgery - NOS NS 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1707030 1707030 1614936 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22695392 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290959 2290959 2157024 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469502 1469502 1393241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468084 1468084 1391930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 93 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205978 2205978 2074211 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106546 2106546 1984409 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770718 1770718 1674958 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637236 1637236 1553284 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731710 1731710 1637676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22806307 NS NS 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1962801 1962801 1849349 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23769878 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469480 1469480 1393219 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469414 1469414 1393153 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214568 2214568 2082692 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081812 2081812 1960234 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481317 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656133 1656133 1570790 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21311943 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535051 1535051 1457386 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637152 1637152 1553200 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1053141 1053141 969212 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17409961 surgery - NOS NS 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777209 1777209 1681212 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1113267 1113267 1026765 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18449007 surgery-fixed NS 42 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000202 2000202 1885100 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983100 983100 898818 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2778770 2778770 2636824 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879529 1879529 1770031 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1479954 1479954 1403614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879543 1879543 1770045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879571 1879571 1770073 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879525 1879525 1770027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-02-0089-01 1910158 1798449 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense hom 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 54 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 ESO-963 1890976 1780345 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV51799199 COSM1251020 132553945 c.1639G>A p.V547I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Reported in another cancer sample as somatic 23525077 surgery fresh/frozen primary 75 ENSP00000395243.3:p.Val547Ile ENST00000454757.6:c.1639G>A 7:g.55165331G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103638 1103638 1017890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 62 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1789304 1789304 1692708 lung NS NS NS carcinoma NS NS NS n COSV51765252 COSM13009 99400543 c.2126A>G p.E709G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000275493.2:p.Glu709Gly ENST00000275493.6:c.2126A>G 7:g.55173985A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879526 1879526 1770028 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1789314 1789314 1692718 lung NS NS NS carcinoma NS NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891230 1891230 1780599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136890 1136890 1049454 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1435992 1435992 1345271 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen NS 85 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 907086 907086 824598 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983729 1983729 1869965 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136895 1136895 1049459 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009150 2009150 1891884 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1107247 1107247 1021159 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891248 1891248 1780617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042906 1042906 959247 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891226 1891226 1780595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897837 897837 815459 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897816 897816 815438 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891290 1891290 1780659 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875796 1875796 1766379 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899343 899343 816955 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2476320 2476320 2339088 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 26870223 fine needle aspirate metastasis 48 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231324 1231324 1143114 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1197363 1197363 1109258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1320683 1320683 1231570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20155428 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1549817 1549817 1471922 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 82 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1882510 1882510 1772646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51803731 COSM28604 132550372 c.2371C>T p.R791C Substitution - Missense het 38 7:55191755-55191755 + - PATHOGENIC .95213 Reported in another cancer sample as somatic 23486275 pleural effusion metastasis 81 ENSP00000395243.3:p.Arg791Cys ENST00000454757.6:c.2371C>T 7:g.55191755C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879235 1879235 1769790 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51787507 COSM13188 132557864 c.2146G>A p.D716N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 23468066 surgery-fixed NS 55 ENSP00000395243.3:p.Asp716Asn ENST00000454757.6:c.2146G>A 7:g.55174818G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924331 924331 841106 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1789320 1789320 1692724 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1046995 1046995 963226 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625563 2625563 2485975 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 51 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631942 1631942 1548812 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659804 2659804 2519962 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479915 1479915 1403575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1530684 1530684 1453056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21227397 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479949 1479949 1403609 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625551 2625551 2485963 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895103 1895103 1783795 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1284673 1284673 1195968 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM28574 178384302 c.? p.P848L Substitution - Missense + - Reported in another cancer sample as somatic 16467085 surgery - NOS NS ENSP00000275493.2:p.Pro848Leu EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983726 1983726 1869962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450858 1450858 1375001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1456618 1456618 1380593 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897824 897824 815446 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899356 899356 816968 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51780206 COSM12373 132553376 c.2024C>T p.S675F Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .9768 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Ser675Phe ENST00000454757.6:c.2024C>T 7:g.55174018C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675155 2675155 2534429 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766268 COSM13183 132550670 c.2090T>C p.V697A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Reported in another cancer sample as somatic 29075127 surgery fresh/frozen NS ENSP00000395243.3:p.Val697Ala ENST00000454757.6:c.2090T>C 7:g.55174762T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659801 2659801 2519959 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891241 1891241 1780610 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891267 1891267 1780636 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860423 1860423 1751364 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231310 1231310 1143100 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2840788 2840788 2696348 prostate NS NS NS carcinoma NS NS NS n COSV51785413 COSM1176673 133211383 c.620G>A p.R207H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 31874108 surgery-fixed metastasis ENSP00000415559.1:p.Arg207His ENST00000455089.5:c.620G>A 7:g.55154018G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1625788 1625788 1543012 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453415 1453415 1377448 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 V43 1179744 1091706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 82 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1435975 1435975 1345254 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery-fixed primary 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 4515 915986 833385 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51849884 COSM13192 132555587 c.2293G>A p.G765S Substitution - Missense 38 7:55181437-55181437 + - PATHOGENIC .98229 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000395243.3:p.Gly765Ser ENST00000454757.6:c.2293G>A 7:g.55181437G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-44-6147-01 1780126 1684125 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51811749 COSM6242 132561254 c.2170G>T p.V724L Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .9836 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 67 ENSP00000395243.3:p.Val724Leu ENST00000454757.6:c.2170G>T 7:g.55181314G>T EGFR ENST00000275493.6 3633 3236 1891310 1891310 1780679 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-02-0016-01 1910129 1798420 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 50 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1000057 1000057 917280 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875354 1875354 1765937 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064723 2064723 1944800 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1991301 1991301 1876636 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1 1433966 1343381 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1573765 1573765 1495234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21982684 surgery fresh/frozen metastasis 44 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1534107 1534107 1456446 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21707848 surgery-fixed metastasis 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891228 1891228 1780597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1038995 1038995 955572 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1295829 1295829 1206901 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19640859 fine needle aspirate primary 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990915 1990915 1876250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226872 2226872 2094607 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2078351 2078351 1957070 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24314215 pleural effusion NS 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2758808 2758808 2617370 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28762784 fine needle aspirate metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895073 1895073 1783765 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862728 2862728 2717891 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1876985 1876985 1767547 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1029024 1029024 945895 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 17075123 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879554 1879554 1770056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1235132 1235132 1146918 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 54 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879505 1879505 1770007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879576 1879576 1770078 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2027349 2027349 1909417 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897806 897806 815428 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1038994 1038994 955571 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2878948 2878948 2733463 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 33115932 surgery-fixed NS 65 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899331 899331 816943 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1627727 1627727 1544639 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1541731 1541731 1464035 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21469767 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899326 899326 816938 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226878 2226878 2094613 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593020 1593020 1513946 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891223 1891223 1780592 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089139 1089139 1004093 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2161696 2161696 2030303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24813888 pleural effusion NS 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1074889 1074889 990143 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17505415 surgery fresh/frozen primary 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372591 2372591 2235384 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1434028 1434028 1343443 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136878 1136878 1049442 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983744 1983744 1869980 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602808 1602808 1522144 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1135421 1135421 1047985 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983718 1983718 1869954 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1667724 1667724 1581017 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345077 2345077 2209749 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-057-tumor 2818998 2675297 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-078-tumor 2819014 2675313 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194730 1194730 1106625 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1078227 1078227 993477 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17626639 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2757127 2757127 2615769 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 132549057 c.2183A>T p.H728L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 29858019 ascites recurrent 50 ENSP00000395243.3:p.His728Leu ENST00000454757.6:c.2183A>T 7:g.55181327A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2757127 2757127 2615769 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 29858019 ascites recurrent 50 ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659761 2659761 2519919 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51802272 COSM13425 132564786 c.2170G>A p.V724M Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .98024 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Val724Met ENST00000454757.6:c.2170G>A 7:g.55181314G>A EGFR ENST00000275493.6 3633 3236 2241836 2241836 2109367 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM28574 178384302 c.? p.P848L Substitution - Missense + - Reported in another cancer sample as somatic 25228365 NS primary ENSP00000275493.2:p.Pro848Leu EGFR ENST00000275493.6 3633 3236 1043129 1043129 959470 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51773049 COSM22943 99376120 c.2543C>T p.P848L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 31 ENSP00000275493.2:p.Pro848Leu ENST00000275493.6:c.2543C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239175 2239175 2106707 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 49 ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-111-tumor 2819034 2675333 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00227T00227 2857348 2712648 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2147905 2147905 2017048 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 45 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879573 1879573 1770075 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879579 1879579 1770081 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891326 1891326 1780695 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891321 1891321 1780690 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042897 1042897 959238 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2422466 2422466 2285388 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25521406 surgery - NOS metastasis 65 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891311 1891311 1780680 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2730697 2730697 2589468 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 132550443 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + Yes Reported in another cancer sample as somatic 29673089 circulating tumour primary 54 ENSP00000395243.3:p.Leu702Pro ENST00000454757.6:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-44-6147-01 1780126 1684125 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 67 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453489 1453489 1377522 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226916 2226916 2094651 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 1734962 1734962 1640906 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 99376120 c.2543C>T p.P848L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 64 ENSP00000275493.2:p.Pro848Leu ENST00000275493.6:c.2543C>T 7:g.55191792C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1526688 1526688 1449056 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51796850 COSM24846 133241496 c.2356C>T p.R786C Substitution - Missense het 38 7:55191740-55191740 + - PATHOGENIC .9406 Reported in another cancer sample as somatic 21573507 surgery-fixed NS ENSP00000415559.1:p.Arg786Cys ENST00000455089.5:c.2356C>T 7:g.55191740C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1141186 1141186 1053634 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 18785203 surgery-fixed NS 67 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 G73 1179731 1091693 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 58 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899330 899330 816942 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AX-A0J0-01 1783376 1687375 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51770777 COSM28286 132563968 c.2359C>T p.R787C Substitution - Missense het 38 7:55191743-55191743 + - PATHOGENIC .95135 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 47 ENSP00000395243.3:p.Arg787Cys ENST00000454757.6:c.2359C>T 7:g.55191743C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239174 2239174 2106706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862108 2862108 2717310 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51841095 COSM133588 99399494 c.2270A>G p.K757R Substitution - Missense 38 7:55174807-55174807 + - PATHOGENIC .9946 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000275493.2:p.Lys757Arg ENST00000275493.6:c.2270A>G 7:g.55174807A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 109596 2812901 2669315 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 72 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226765 2226765 2094500 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00414T00414 2857361 2712661 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-075-tumor 2819011 2675310 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 273T 910551 828036 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766928 COSM12718 132551704 c.2045A>G p.Y682C Substitution - Missense het 38 7:55174039-55174039 + - PATHOGENIC .97626 Reported in another cancer sample as somatic 15735034 cell-line NS ENSP00000395243.3:p.Tyr682Cys ENST00000454757.6:c.2045A>G 7:g.55174039A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1517053 1517053 1439647 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 49 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00207T00207 2857359 2712659 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005460 1005460 922672 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51777202 COSM20896 133246500 c.2365G>A p.V789M Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 16822827 fixed - NOS NS 24 ENSP00000415559.1:p.Val789Met ENST00000455089.5:c.2365G>A 7:g.55191749G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 6 1077305 992559 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51815927 COSM24971 132563635 c.2378T>C p.L793P Substitution - Missense 38 7:55191762-55191762 + - PATHOGENIC .97813 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu793Pro ENST00000454757.6:c.2378T>C 7:g.55191762T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899345 899345 816957 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1197352 1197352 1109247 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891283 1891283 1780652 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1618762 1618762 1537514 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22215752 surgery-fixed NS 81 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618750 1618750 1537502 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 76 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1996925 1996925 1882134 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 63 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081915 2081915 1960337 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2894934 2894934 2749418 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS primary 58 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 4A 2529059 2390915 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 fine needle aspirate recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027748 2027748 1909651 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525742 2525742 2387930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2803991 2803991 2660719 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 31254668 surgery - NOS recurrent 79 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2815054 2815054 2671442 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29807405 surgery - NOS metastasis 59 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2346517 2346517 2211180 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2105833 2105833 1983871 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1547792 1547792 1469914 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 75 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525744 2525744 2387932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525726 2525726 2387914 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2731049 2731049 2589816 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing_non_differentiated NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25963410 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2906658 2906658 2760909 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29616327 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2908158 2908158 2762333 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 33260286 surgery - NOS NS 64 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027782 2027782 1909685 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746674 1746674 1651650 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 71 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879518 1879518 1770020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879504 1879504 1770006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891332 1891332 1780701 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1082437 1082437 997655 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17649787 autopsy-fixed recurrent 32 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879502 1879502 1770004 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1517053 1517053 1439647 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 49 ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302274 1302274 1213325 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1197366 1197366 1109261 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899317 899317 816929 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226885 2226885 2094620 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983776 1983776 1870012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983701 1983701 1869937 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1456552 1456552 1380527 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891202 1891202 1780571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668525 1668525 1581818 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1075002 1075002 990256 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 55 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1734960 1734960 1640904 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 33 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064719 2064719 1944796 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983825 1983825 1870061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990906 1990906 1876241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897285 897285 814908 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 15118073 surgery-fixed primary 58 ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166432 1166432 1078746 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51815934 COSM28607 133206383 c.2468A>G p.E823G Substitution - Missense hom 38 7:55191852-55191852 + - PATHOGENIC .96745 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 59 ENSP00000415559.1:p.Glu823Gly ENST00000455089.5:c.2468A>G 7:g.55191852A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891316 1891316 1780685 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891334 1891334 1780703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042902 1042902 959243 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899327 899327 816939 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1074948 1074948 990202 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625562 2625562 2485974 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 51 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1120914 1120914 1034070 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1874662 1874662 1765253 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522884 1522884 1445256 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676425 1676425 1589193 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264340 2264340 2131324 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838703 1838703 1732804 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 811 1716353 1623915 lung right_upper_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22733594 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345563 2345563 2210235 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1435967 1435967 1345246 lung right_lower_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery-fixed primary 47 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2029005 2029005 1910887 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618762 1618762 1537514 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 81 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921931 1921931 1809249 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1513413 1513413 1436074 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21497370 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549156 2549156 2410611 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770622 1770622 1674862 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026258 2026258 1908347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680557 2680557 2539830 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618750 1618750 1537502 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547807 1547807 1469929 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed primary 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141298 1141298 1053746 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996580 1996580 1881789 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23922984 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842987 1842987 1736235 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1135347 1135347 1047913 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17591931 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345389 2345389 2210061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986171 1986171 1872407 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1795778 1795778 1697526 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23110940 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430056 1430056 1339474 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542356 1542356 1464659 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1154307 1154307 1066643 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18957054 surgery-fixed NS 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1523390 1523390 1445762 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21626329 surgery-fixed recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346521 2346521 2211184 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618891 1618891 1537643 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1715965 1715965 1623527 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22760226 surgery - NOS recurrent 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914959 1914959 1802961 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329245 1329245 1239730 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264109 2264109 2131093 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421166 2421166 2284088 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120914 1120914 1034070 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214560 2214560 2082684 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879528 1879528 1770030 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 4 2570195 2431492 skin face NS NS adnexal_tumour sebaceous_carcinoma NS NS n COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 53 ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 1479092 1479092 1402785 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 T4499 2823144 2678998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28818608 surgery-fixed NS 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937515 1937515 1824449 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637180 1637180 1553228 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148598 2148598 2017728 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914913 1914913 1802915 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1523389 1523389 1445761 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21626329 surgery-fixed recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264309 2264309 2131293 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096038 2096038 1974102 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345589 2345589 2210261 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046005 2046005 1926300 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345376 2345376 2210048 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226172 2226172 2093907 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469486 1469486 1393225 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983105 983105 898823 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1486481 1486481 1410099 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21107288 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469474 1469474 1393213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476320 2476320 2339088 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 26870223 fine needle aspirate metastasis 48 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2096071 2096071 1974135 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983116 983116 898834 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593028 1593028 1513954 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2594469 2594469 2455345 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28178168 NS recurrent 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770576 1770576 1674816 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345585 2345585 2210257 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2867467 2867467 2722542 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 32441866 bronchoalveolar lavage fluid NS 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027863 2027863 1909766 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142089 2142089 2011307 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1962853 1962853 1849401 lung right NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23741221 surgery - NOS primary 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637083 1637083 1553131 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1303920 1303920 1214971 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20028932 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2157007 2157007 2025982 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525742 2525742 2387930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096104 2096104 1974168 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2803991 2803991 2660719 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31254668 surgery - NOS recurrent 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120922 1120922 1034078 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345581 2345581 2210253 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246623 1246623 1158302 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637643 2637643 2498016 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 surgery - NOS primary 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777314 1777314 1681317 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264243 2264243 2131227 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547794 1547794 1469916 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1284749 1284749 1196044 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16467085 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964316 1964316 1850851 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1661841 1661841 1575454 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22487432 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2156997 2156997 2025972 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142061 2142061 2011279 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983140 983140 898858 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838661 1838661 1732762 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425758 2425758 2288679 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345107 2345107 2209779 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2078484 2078484 1957203 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345055 2345055 2209727 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2106485 2106485 1984348 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24575772 surgery - NOS NS 51 ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-RR-A6KC-01 2339255 2204238 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 133208833 c.619C>T p.R207C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 NS primary 55 ENSP00000415559.1:p.Arg207Cys ENST00000455089.5:c.619C>T 7:g.55154017C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S002024 1027695 944671 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51785554 COSM21688 132548847 c.836G>T p.R279L Substitution - Missense het 38 7:55155911-55155911 + - PATHOGENIC .97287 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Arg279Leu ENST00000454757.6:c.836G>T 7:g.55155911G>T EGFR ENST00000275493.6 3633 3236 2625578 2625578 2485990 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 74 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2664364 2664364 2524424 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 36 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1162972 1162972 1075295 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 18992959 NS recurrent 65 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096244 2096244 1974308 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2345116 2345116 2209788 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2096240 2096240 1974304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1856349 1856349 1748902 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS metastasis ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 T1751 2823156 2679009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 28818608 surgery-fixed NS 65 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1966250 1966250 1852743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM53180 178383586 c.? p.G873E Substitution - Missense + - Reported in another cancer sample as somatic 23800712 fixed - NOS NS ENSP00000275493.2:p.Gly873Glu EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098870 1098870 1013462 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1451644 1451644 1375787 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51829458 COSM51497 99381092 c.2237_2238inv p.E746V Substitution - Missense 38 7:55174774-55174775 + - Reported in another cancer sample as somatic 20855820 surgery - NOS NS ENSP00000275493.2:p.Glu746Val ENST00000275493.6:c.2237_2238inv 7:g.55174774_55174775inv EGFR ENST00000275493.6 3633 3236 1770669 1770669 1674909 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469415 1469415 1393154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2865565 2865565 2720695 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29120087 surgery-fixed primary 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479078 1479078 1402771 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105833 2105833 1983871 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965895 1965895 1852388 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1668667 1668667 1581959 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22523351 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345356 2345356 2210028 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469435 1469435 1393174 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637141 1637141 1553189 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046040 2046040 1926335 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027810 2027810 1909713 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008969 2008969 1891703 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23979198 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264235 2264235 2131219 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469363 1469363 1393102 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2471442 2471442 2334228 skin NS NS NS malignant_melanoma NS NS NS n COSV51836136 COSM5574310 133222649 c.2764G>A p.E922K Substitution - Missense 38 7:55200366-55200366 + - PATHOGENIC .99379 Reported in another cancer sample as somatic 25452114 surgery fresh/frozen metastasis 55 ENSP00000415559.1:p.Glu922Lys ENST00000455089.5:c.2764G>A 7:g.55200366G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00355T00355 2857331 2712631 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593029 1593029 1513955 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2525744 2525744 2387932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345433 2345433 2210105 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1148664 1148664 1061105 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18829487 surgery fresh/frozen NS 36 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459506 1459506 1383449 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2437328 2437328 2300178 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23211219 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226179 2226179 2093914 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1661392 1661392 1575007 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 22483783 surgery-fixed NS 61 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1887409 1887409 1777081 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096107 2096107 1974171 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637172 1637172 1553220 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469453 1469453 1393192 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1882244 1882244 1772395 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23392229 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469469 1469469 1393208 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459526 1459526 1383469 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1097643 1097643 1012304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2078471 2078471 1957190 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1024771 1024771 941748 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17020982 surgery fresh/frozen metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046051 2046051 1926346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656105 1656105 1570762 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21311943 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587261 1587261 1508432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469463 1469463 1393202 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838692 1838692 1732793 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469434 1469434 1393173 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777249 1777249 1681252 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141329 1141329 1053777 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011161 2011161 1893799 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676420 1676420 1589188 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264096 2264096 2131080 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2864411 2864411 2719568 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26199566 surgery-fixed NS 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096097 2096097 1974161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777374 1777374 1681377 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1512595 1512595 1435279 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21508367 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345593 2345593 2210265 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838553 1838553 1732654 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444789 1444789 1369032 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469352 1469352 1393091 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1882530 1882530 1772665 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23486266 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-174-tumor 2819067 2675366 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-230-tumor 2819105 2675404 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1434026 1434026 1343441 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1789323 1789323 1692727 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372765 2372765 2235558 pleura NS NS NS mesothelioma NS NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24569782 surgery-fixed NS 72 ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1874753 1874753 1765344 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474350 2474350 2337119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665712 2665712 2525421 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS metastasis 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000223 2000223 1885121 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887392 1887392 1777064 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914956 1914956 1802958 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493361 1493361 1416351 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095887 2095887 1973951 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1060147 1060147 976192 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17406029 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027782 2027782 1909685 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345419 2345419 2210091 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345451 2345451 2210123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475396 1475396 1399095 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986159 1986159 1872395 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246672 1246672 1158351 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965819 1965819 1852312 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637167 1637167 1553215 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-B5-A0JZ-01 1783389 1687388 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51823220 COSM13179 99386001 c.2080C>T p.P694S Substitution - Missense hom 38 7:55173939-55173939 + - PATHOGENIC .97389 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 60 ENSP00000275493.2:p.Pro694Ser ENST00000275493.6:c.2080C>T 7:g.55173939C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1981023 1981023 1867259 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594601 1594601 1515569 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895128 1895128 1783820 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1610921 1610921 1530149 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22157931 surgery-fixed primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1434017 1434017 1343432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625558 2625558 2485970 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891219 1891219 1780588 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895084 1895084 1783776 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1549818 1549818 1471923 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592989 1592989 1513915 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098866 1098866 1013458 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1295380 1295380 1206459 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19881244 surgery-fixed NS 90 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110465 1110465 1024343 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1575150 1575150 1496591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Sq-1 946075 862601 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1310473 1310473 1221418 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1090038 1090038 1004985 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17945377 surgery - NOS primary 32 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2476903 2476903 2339672 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990912 1990912 1876247 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983765 1983765 1870001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239178 2239178 2106710 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 53 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1523014 1523014 1445386 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 72 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1523012 1523012 1445384 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 71 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879487 1879487 1769989 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879561 1879561 1770063 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51834362 COSM6503269 132557758 c.2018T>A p.L673Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000395243.3:p.Leu673Gln ENST00000454757.6:c.2018T>A 7:g.55174012T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1931642 1931642 1818932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1512594 1512594 1435278 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21508367 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1823850 1823850 1722244 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23212424 surgery-fixed metastasis 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842957 1842957 1736205 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1514591 1514591 1437202 lung right_lower_lobe NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21556797 surgery - NOS primary 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777342 1777342 1681345 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770652 1770652 1674892 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025411 2025411 1907500 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1635372 1635372 1551877 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22335887 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011152 2011152 1893790 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2865684 2865684 2720760 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26384434 surgery - NOS primary 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667696 1667696 1580989 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602814 1602814 1522150 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429292 1429292 1338743 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2076208 2076208 1955020 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24406864 surgery-fixed primary 27 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668459 1668459 1581752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895083 1895083 1783775 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-49-4490-01 1780137 1684136 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 45 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 16 1433981 1343396 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1047000 1047000 963231 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453496 1453496 1377529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001552 1001552 918775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15851406 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1575146 1575146 1496587 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1074947 1074947 990201 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 45 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1751706 1751706 1656522 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2078360 2078360 1957079 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24314215 pleural effusion NS 49 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009151 2009151 1891885 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077334 1077334 992588 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089597 1089597 1004544 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924336 924336 841111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1295828 1295828 1206900 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19640859 fine needle aspirate primary 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042910 1042910 959251 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1200918 1200918 1112808 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103633 1103633 1017885 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990905 1990905 1876240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2732896 2732896 2591649 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 58 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2808102 2808102 2664786 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 31258848 surgery-fixed NS 60 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479954 1479954 1403614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009153 2009153 1891887 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429329 1429329 1338780 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895160 1895160 1783852 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1541741 1541741 1464045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21469767 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1310479 1310479 1221424 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891269 1891269 1780638 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1200917 1200917 1112807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983823 1983823 1870059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1000056 1000056 917279 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602801 1602801 1522137 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1876989 1876989 1767551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983704 1983704 1869940 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450921 1450921 1375064 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 81 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1974002 1974002 1860244 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773712 COSM13433 132558066 c.2183A>G p.H728R Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98391 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000395243.3:p.His728Arg ENST00000454757.6:c.2183A>G 7:g.55181327A>G EGFR ENST00000275493.6 3633 3236 KTA-7 946051 862577 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980069 1980069 1866312 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 73 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879510 1879510 1770012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879549 1879549 1770051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 H1975 2776253 2634389 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29681454 NS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980067 1980067 1866310 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 68 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862785 2862785 2717948 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897811 897811 815433 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2026152 2026152 1908241 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766168 COSM1716256 132551981 c.2093C>T p.A698V Substitution - Missense het 38 7:55174765-55174765 + - PATHOGENIC .99382 Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000395243.3:p.Ala698Val ENST00000454757.6:c.2093C>T 7:g.55174765C>T EGFR ENST00000275493.6 3633 3236 1668448 1668448 1581741 lung bronchus NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22526156 surgery-fixed primary 25 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1592973 1592973 1513899 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51803771 COSM14068 99392333 c.2308G>A p.D770N Substitution - Missense 38 7:55181317-55181317 + - PATHOGENIC .97623 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Asp770Asn ENST00000275493.6:c.2308G>A 7:g.55181317G>A EGFR ENST00000275493.6 3633 3236 1696881 1696881 1605009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22674612 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592970 1592970 1513896 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773111 COSM13185 133203473 c.2117C>T p.T706I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Thr706Ile ENST00000455089.5:c.2117C>T 7:g.55174789C>T EGFR ENST00000275493.6 3633 3236 1174289 1174289 1086308 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2862254 2862254 2717444 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25969368 surgery-fixed primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 PC-7 946057 862583 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2675682 2675682 2534956 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 29100434 surgery - NOS recurrent ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 2778633 2778633 2636687 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS n COSV51820767 COSM53288 99383393 c.2354C>T p.T785I Substitution - Missense 38 7:55181363-55181363 + - PATHOGENIC .9109 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000275493.2:p.Thr785Ile ENST00000275493.6:c.2354C>T 7:g.55181363C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891331 1891331 1780700 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891331 1891331 1780700 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 6374 915984 833383 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51860329 COSM13190 132563568 c.2240T>C p.L747P Substitution - Missense 38 7:55181384-55181384 + - PATHOGENIC .95089 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000395243.3:p.Leu747Pro ENST00000454757.6:c.2240T>C 7:g.55181384T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2734339 2734339 2593066 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 29731638 circulating tumour recurrent 52 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098816 1098816 1013408 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1587201 1587201 1508372 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1551501 1551501 1473606 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1731711 1731711 1637677 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 22809298 NS NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 SNU-638 2807650 2664351 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51777111 COSM33725 99387470 c.2609A>G p.H870R Substitution - Missense 38 7:55191858-55191858 + - PATHOGENIC .97748 Reported in another cancer sample as somatic 24807215 cell-line NS 48 ENSP00000275493.2:p.His870Arg ENST00000275493.6:c.2609A>G 7:g.55191858A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2696524 2696524 2555428 central_nervous_system middle_frontal_gyrus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28201779 surgery fresh/frozen NS 56 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 618-1503-04TD 1921502 1808820 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51797215 COSM145360 132558158 c.832G>A p.V278I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Reported in another cancer sample as somatic 340 blood NS ENSP00000395243.3:p.Val278Ile ENST00000454757.6:c.832G>A 7:g.55155907G>A EGFR ENST00000275493.6 3633 3236 1094000 1094000 1008702 urinary_tract bladder NS NS carcinoma NS NS NS n COSV51816100 COSM13430 99401741 c.2515G>A p.A839T Substitution - Missense 38 7:55191764-55191764 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 17707060 surgery fresh/frozen NS ENSP00000275493.2:p.Ala839Thr ENST00000275493.6:c.2515G>A 7:g.55191764G>A EGFR ENST00000275493.6 3633 3236 1551566 1551566 1473671 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM53179 178383575 c.? p.V834L Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Val834Leu EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592972 1592972 1513898 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768262 COSM26445 132550179 c.2165C>T p.A722V Substitution - Missense 38 7:55181309-55181309 + - PATHOGENIC .97799 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Ala722Val ENST00000454757.6:c.2165C>T 7:g.55181309C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625554 2625554 2485966 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1661392 1661392 1575007 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22483783 surgery-fixed NS 61 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1891299 1891299 1780668 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1047008 1047008 963239 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1194737 1194737 1106632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 2785996 2785996 2643453 large_intestine colon right NS carcinoma neuroendocrine_carcinoma NS NS n COSV51787507 COSM13188 99385457 c.2281G>A p.D761N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 27586204 NS NS 72 ENSP00000275493.2:p.Asp761Asn ENST00000275493.6:c.2281G>A 7:g.55174818G>A EGFR ENST00000275493.6 3633 3236 2345067 2345067 2209739 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899358 899358 816970 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1066987 1066987 982967 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17504988 surgery-fixed NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 G37 1063245 979290 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 70 ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924446 924446 841221 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 16198442 surgery - NOS recurrent 58 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0002PT00018T00018 2857363 2712663 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-121-tumor 2819042 2675341 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0219-01 1910209 1798500 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 67 ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891215 1891215 1780584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2559408 2559408 2420832 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM53179 178383575 c.? p.V834L Substitution - Missense + - Reported in another cancer sample as somatic 24158231 surgery fresh/frozen NS 69 ENSP00000275493.2:p.Val834Leu EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043129 1043129 959470 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51773049 COSM22943 132549396 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 31 ENSP00000395243.3:p.Pro803Leu ENST00000454757.6:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592888 1592888 1513814 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162207 1162207 1074539 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766880 COSM28516 132563580 c.2269G>T p.V757F Substitution - Missense 38 7:55181413-55181413 + - PATHOGENIC .89385 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000395243.3:p.Val757Phe ENST00000454757.6:c.2269G>T 7:g.55181413G>T EGFR ENST00000275493.6 3633 3236 2214577 2214577 2082701 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1526361 1526361 1448729 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 21623281 surgery - NOS NS 68 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1983724 1983724 1869960 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891259 1891259 1780628 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1077333 1077333 992587 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1990913 1990913 1876248 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1200921 1200921 1112811 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1089604 1089604 1004551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1231318 1231318 1143108 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895137 1895137 1783829 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LUAD-NYU1142 1765136 1669456 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226916 2226916 2094651 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777782 COSM6227 132554599 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.His790Leu ENST00000454757.6:c.2369A>T 7:g.55191753A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239188 2239188 2106720 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777782 COSM6227 132554599 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 25130612 fine needle aspirate NS 75 ENSP00000395243.3:p.His790Leu ENST00000454757.6:c.2369A>T 7:g.55191753A>T EGFR ENST00000275493.6 3633 3236 1891197 1891197 1780566 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1089138 1089138 1004092 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1517068 1517068 1439662 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1429252 1429252 1338703 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1594554 1594554 1515522 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924330 924330 841105 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862725 2862725 2717888 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895164 1895164 1783856 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1197355 1197355 1109250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897815 897815 815437 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DCR7 1690657 1598934 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 132560744 c.1341C>A p.S447R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000395243.3:p.Ser447Arg ENST00000454757.6:c.1341C>A 7:g.55160316C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1839254 1839254 1733355 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51776282 COSM1168015 132547141 c.2123C>T p.P708L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Reported in another cancer sample as somatic 23244191 surgery-fixed primary ENSP00000395243.3:p.Pro708Leu ENST00000454757.6:c.2123C>T 7:g.55174795C>T EGFR ENST00000275493.6 3633 3236 5-GE101-T1 2869805 2724802 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51822498 COSM3266565 99412489 c.917C>T p.S306L Substitution - Missense 38 7:55155857-55155857 + - PATHOGENIC .98807 Reported in another cancer sample as somatic 26950094 surgery - NOS NS 81 ENSP00000275493.2:p.Ser306Leu ENST00000275493.6:c.917C>T 7:g.55155857C>T EGFR ENST00000275493.6 3633 3236 AA3-2 2539101 2400690 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSM34167 178379046 c.? p.G598V Substitution - Missense + - Reported in another cancer sample as somatic 25257301 surgery-fixed NS ENSP00000275493.2:p.Gly598Val EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602815 1602815 1522151 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875805 1875805 1766388 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1435991 1435991 1345270 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen primary 85 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983786 1983786 1870022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-201-tumor 2819084 2675383 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625554 2625554 2485966 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2113071 2113071 1987332 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51787507 COSM13188 132557864 c.2146G>A p.D716N Substitution - Missense het 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 24595526 surgery-fixed NS ENSP00000395243.3:p.Asp716Asn ENST00000454757.6:c.2146G>A 7:g.55174818G>A EGFR ENST00000275493.6 3633 3236 1983738 1983738 1869974 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2778771 2778771 2636825 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1980061 1980061 1866304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 69 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1024780 1024780 941757 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879568 1879568 1770070 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1141191 1141191 1053639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 18785203 autopsy-fixed NS 78 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 LUAD-NYU1142 1765136 1669456 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 72 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1040049 1040049 956626 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17180521 surgery - NOS recurrent 57 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166443 1166443 1078757 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009164 2009164 1891898 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1310475 1310475 1221420 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891250 1891250 1780619 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103630 1103630 1017882 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471794 1471794 1395532 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089136 1089136 1004090 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089600 1089600 1004547 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1541735 1541735 1464039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21469767 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226897 2226897 2094632 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1435995 1435995 1345274 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery-fixed primary 59 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924334 924334 841109 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990908 1990908 1876243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983706 1983706 1869942 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862729 2862729 2717892 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668553 1668553 1581846 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593004 1593004 1513930 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1530670 1530670 1453042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21227397 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1694963 1694963 1603183 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990907 1990907 1876242 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920160 920160 837240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 47 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899338 899338 816950 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766493 COSM6493937 132560202 c.2254T>A p.C752S Substitution - Missense het 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239175 2239175 2106707 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51777782 COSM6227 132554599 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 49 ENSP00000395243.3:p.His790Leu ENST00000454757.6:c.2369A>T 7:g.55191753A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1047910 1047910 964139 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17335935 pleural effusion recurrent 83 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1882612 1882612 1772747 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23493804 pleural effusion metastasis 72 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1973999 1973999 1860241 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1789317 1789317 1692721 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668523 1668523 1581816 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2035481 2035481 1916843 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24034463 pleural effusion recurrent 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2240677 2240677 2108208 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 64 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2046170 2046170 1926465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668469 1668469 1581762 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780766 COSM219795 133202085 c.2456C>T p.A819V Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .93098 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Ala819Val ENST00000455089.5:c.2456C>T 7:g.55191840C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042901 1042901 959242 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983778 1983778 1870014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1517071 1517071 1439665 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 11-18-GEF10-1 1731375 1637341 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22815900 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593013 1593013 1513939 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895112 1895112 1783804 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1981027 1981027 1867263 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067041 1067041 983021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450932 1450932 1375075 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 56 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1031899 1031899 948690 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17085664 NS recurrent ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2616331 2616331 2476817 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26118982 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982785 982785 898504 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-F00134 1765150 1669470 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 87 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110466 1110466 1024344 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302272 1302272 1213323 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162207 1162207 1074539 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1881375 1881375 1771526 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659797 2659797 2519955 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51782636 COSM85961 132548929 c.2383G>A p.A795T Substitution - Missense 38 7:55191767-55191767 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Ala795Thr ENST00000454757.6:c.2383G>A 7:g.55191767G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2027347 2027347 1909415 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 52 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1882523 1882523 1772658 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23486266 surgery-fixed primary ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1996924 1996924 1882133 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 63 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618695 1618695 1537447 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 66 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1731104 1731104 1637075 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22815900 cerebrospinal fluid recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1596620 1596620 1517402 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22071596 blood-bone marrow NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096235 2096235 1974299 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2141456 2141456 2010674 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24636848 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027734 2027734 1909637 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2426852 2426852 2289773 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2402480 2402480 2265336 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 57 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 19B 2529063 2390919 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2228279 2228279 2096007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00443T00443 2857349 2712649 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-050-tumor 2818996 2675295 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2078354 2078354 1957073 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24314215 fine needle aspirate NS 57 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879507 1879507 1770009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2595751 2595751 2456627 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2476903 2476903 2339672 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1459519 1459519 1383462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2437322 2437322 2300172 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23211219 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469459 1469459 1393198 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1882523 1882523 1772658 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23486266 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983131 983131 898849 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345441 2345441 2210113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965853 1965853 1852346 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680537 2680537 2539810 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637243 1637243 1553291 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549132 2549132 2410587 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551566 1551566 1473671 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095991 2095991 1974055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965834 1965834 1852327 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226169 2226169 2093904 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218534 2218534 2086545 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047781 2047781 1928053 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240551 2240551 2108082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25227801 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770660 1770660 1674900 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551501 1551501 1473606 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 10 2570187 2431484 skin face NS NS adnexal_tumour other sebaceoma NS n COSV51768262 COSM26445 99377063 c.2300C>T p.A767V Substitution - Missense 38 7:55181309-55181309 + - PATHOGENIC .97799 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 76 ENSP00000275493.2:p.Ala767Val ENST00000275493.6:c.2300C>T 7:g.55181309C>T EGFR ENST00000275493.6 3633 3236 1532698 1532698 1455058 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20925915 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203096 2203096 2071354 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618695 1618695 1537447 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1140936 1140936 1053384 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448998 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921920 1921920 1809238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095944 2095944 1974008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2750877 2750877 2609573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27086595 surgery-fixed NS 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731104 1731104 1637075 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22815900 cerebrospinal fluid recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731381 1731381 1637347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22457323 NS NS 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444757 1444757 1369000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1596620 1596620 1517402 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22071596 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026249 2026249 1908338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203082 2203082 2071340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734181 1734181 1640130 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22843912 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096014 2096014 1974078 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174329 1174329 1086348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838706 1838706 1732807 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345523 2345523 2210195 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148510 2148510 2017640 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875686 1875686 1766269 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1993867 1993867 1879123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23892415 surgery-fixed metastasis 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026251 2026251 1908340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095898 2095898 1973962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1445190 1445190 1369433 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20682976 surgery - NOS metastasis 85 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1062888 1062888 978933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17387741 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029025 2029025 1910907 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045969 2045969 1926264 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637129 1637129 1553177 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469500 1469500 1393239 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1635870 1635870 1551974 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22102479 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1522943 1522943 1445315 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 63 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891320 1891320 1780689 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1279041 1279041 1190337 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed metastasis 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1154313 1154313 1066649 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18957054 surgery-fixed NS 87 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1113041 1113041 1026542 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18458038 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777270 1777270 1681273 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770639 1770639 1674879 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838654 1838654 1732755 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469450 1469450 1393189 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1909761 1909761 1798278 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23559152 surgery-fixed NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838711 1838711 1732812 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960184 1960184 1846824 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264157 2264157 2131141 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246621 1246621 1158300 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430051 1430051 1339469 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205966 2205966 2074199 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174326 1174326 1086345 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778772 2778772 2636826 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2733535 2733535 2592288 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29704676 circulating tumour recurrent 36 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879235 1879235 1769790 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23468066 surgery-fixed NS 55 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1024775 1024775 941752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 surgery fresh/frozen recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 20 2570182 2431479 skin ear NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51778659 COSM14070 132547729 c.2453G>A p.G818D Substitution - Missense 38 7:55191837-55191837 + - PATHOGENIC .92688 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 70 ENSP00000395243.3:p.Gly818Asp ENST00000454757.6:c.2453G>A 7:g.55191837G>A EGFR ENST00000275493.6 3633 3236 2113070 2113070 1987331 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 99375118 c.2252C>T p.T751I Substitution - Missense het 38 7:55174789-55174789 + - PATHOGENIC .99151 Reported in another cancer sample as somatic 24595526 surgery-fixed NS ENSP00000275493.2:p.Thr751Ile ENST00000275493.6:c.2252C>T 7:g.55174789C>T EGFR ENST00000275493.6 3633 3236 2372584 2372584 2235377 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891264 1891264 1780633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891258 1891258 1780627 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891272 1891272 1780641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1549839 1549839 1471944 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 77 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 911622 911622 829105 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2659803 2659803 2519961 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2421229 2421229 2284151 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228279 2228279 2096007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096067 2096067 1974131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2894938 2894938 2749420 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS primary 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618050 1618050 1536846 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664325 2664325 2524405 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed primary 32 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1855994 1855994 1748547 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095929 2095929 1973993 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 907081 907081 824593 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897802 897802 815424 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1790517 1790517 1693496 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766268 COSM13183 132550670 c.2090T>C p.V697A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Reported in another cancer sample as somatic 16152581 fixed - NOS NS ENSP00000395243.3:p.Val697Ala ENST00000454757.6:c.2090T>C 7:g.55174762T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982785 982785 898504 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 897805 897805 815427 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862722 2862722 2717885 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2161697 2161697 2030304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24813888 surgery - NOS recurrent 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920163 920163 837243 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226907 2226907 2094642 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895140 1895140 1783832 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1789321 1789321 1692725 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1789322 1789322 1692726 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1075912 1075912 991166 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899322 899322 816934 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1043855 1043855 960196 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875792 1875792 1766375 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2064712 2064712 1944789 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891295 1891295 1780664 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2805811 2805811 2662548 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 31348837 surgery - NOS NS ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194736 1194736 1106631 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 2675373 2675373 2534647 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767379 COSM85894 99384993 c.2527G>A p.V843I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Val843Ile ENST00000275493.6:c.2527G>A 7:g.55191776G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043124 1043124 959465 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51789261 COSM12986 132561937 c.2294G>A p.G765D Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98244 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 54 ENSP00000395243.3:p.Gly765Asp ENST00000454757.6:c.2294G>A 7:g.55181438G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2785975 2785975 2643435 large_intestine colon ascending NS carcinoma neuroendocrine_carcinoma NS NS n COSV51781835 COSM174732 132552286 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Reported in another cancer sample as somatic 28730258 surgery-fixed primary 61 ENSP00000395243.3:p.Glu114Lys ENST00000454757.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879512 1879512 1770014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891334 1891334 1780703 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879482 1879482 1769984 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879545 1879545 1770047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1160958 1160958 1073294 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM24429 178380423 c.? p.E709G Substitution - Missense + - Reported in another cancer sample as somatic 19002495 surgery-fixed primary 71 ENSP00000275493.2:p.Glu709Gly EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51832111 COSM6493934 132563564 c.2240T>A p.L747H Substitution - Missense het 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000395243.3:p.Leu747His ENST00000454757.6:c.2240T>A 7:g.55181384T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862787 2862787 2717950 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767280 COSM133183 132563720 c.2007G>C p.K669N Substitution - Missense 38 7:55174001-55174001 + - PATHOGENIC .89357 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Lys669Asn ENST00000454757.6:c.2007G>C 7:g.55174001G>C EGFR ENST00000275493.6 3633 3236 2676353 2676353 2535627 penis NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM34166 178380439 c.? p.R108K Substitution - Missense + - Reported in another cancer sample as somatic 26216163 surgery-fixed NS ENSP00000275493.2:p.Arg108Lys EGFR ENST00000275493.6 3633 3236 1885137 1885137 1775024 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 23466741 pericardial fluid recurrent 75 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032212 2032212 1913683 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2426832 2426832 2289753 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668551 1668551 1581844 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1965927 1965927 1852420 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032252 2032252 1913723 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1167797 1167797 1080039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19057270 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1591007 1591007 1512123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746649 1746649 1651625 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 80 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096302 2096302 1974366 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2076980 2076980 1955729 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed recurrent 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983119 983119 898837 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045977 2045977 1926272 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120921 1120921 1034077 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2684444 2684444 2543482 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29128427 NS primary 44 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664343 2664343 2524414 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1435650 1435650 1344929 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20661086 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421163 2421163 2284085 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336847 1336847 1247232 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777254 1777254 1681257 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638776 1638776 1554775 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469493 1469493 1393232 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965813 1965813 1852306 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246698 1246698 1158377 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770519 1770519 1674759 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345470 2345470 2210142 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000205-T01-IM3 2714809 2573630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983757 1983757 1869993 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 983162 983162 898880 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1235139 1235139 1146925 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19589612 surgery - NOS recurrent 84 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2033581 2033581 1915030 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24137397 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542177 1542177 1464480 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141327 1141327 1053775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1635458 1635458 1551963 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22333554 surgery-fixed primary 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1202165 1202165 1114051 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19371962 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345460 2345460 2210132 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1445185 1445185 1369428 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20682976 surgery - NOS primary 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1706968 1706968 1614874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22722787 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1235140 1235140 1146926 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 84 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264179 2264179 2131163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2661746 2661746 2521883 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28891180 circulating tumour NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770629 1770629 1674869 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469868 1469868 1393607 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1483086 1483086 1406715 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21163115 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026244 2026244 1908333 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1823864 1823864 1722258 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23212424 surgery-fixed metastasis 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096069 2096069 1974133 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444742 1444742 1368985 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000157 2000157 1885055 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205971 2205971 2074204 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637188 1637188 1553236 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096073 2096073 1974137 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777307 1777307 1681310 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046057 2046057 1926352 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1696877 1696877 1605005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22674612 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081817 2081817 1960239 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481317 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214530 2214530 2082654 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637214 1637214 1553262 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774689 1774689 1678913 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS primary 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777397 1777397 1681400 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046017 2046017 1926312 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734090 1734090 1640039 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22842370 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264251 2264251 2131235 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937529 1937529 1824463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264107 2264107 2131091 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965927 1965927 1852420 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1695718 1695718 1603930 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22673630 surgery - NOS primary 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2482729 2482729 2345456 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26893581 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1052971 1052971 969042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17410005 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475391 1475391 1399090 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459494 1459494 1383437 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 907082 907082 824594 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980078 1980078 1866321 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 60 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778768 2778768 2636822 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1530684 1530684 1453056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21227397 surgery-fixed NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1278399 1278399 1189695 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19596957 cerebrospinal fluid metastasis 51 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1895170 1895170 1783862 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879580 1879580 1770082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51796944 COSM28537 133210567 c.2425A>G p.T809A Substitution - Missense 38 7:55191809-55191809 + - PATHOGENIC .9858 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr809Ala ENST00000455089.5:c.2425A>G 7:g.55191809A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD_E01319 1765124 1669444 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51801471 COSM53105 132553118 c.2357G>A p.R786H Substitution - Missense 38 7:55191741-55191741 + - PATHOGENIC .96289 Reported in another cancer sample as somatic 22980975 surgery - NOS primary ENSP00000395243.3:p.Arg786His ENST00000454757.6:c.2357G>A 7:g.55191741G>A EGFR ENST00000275493.6 3633 3236 1853686 1853686 1746289 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 23325582 surgery-fixed primary ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 MG-156-tumor 2819056 2675355 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00143T00143 2857358 2712658 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 pros_01_dx 2688203 2547185 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 544 NS primary 41 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862785 2862785 2717948 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924513 924513 841286 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2701198 2701198 2560102 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing_non_differentiated NS n COSV51769863 COSM1090888 99381430 c.2224G>A p.V742I Substitution - Missense het 38 7:55174761-55174761 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 28581676 surgery-fixed NS 48 ENSP00000275493.2:p.Val742Ile ENST00000275493.6:c.2224G>A 7:g.55174761G>A EGFR ENST00000275493.6 3633 3236 TCGA-D1-A174-01 1783520 1687519 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51769863 COSM1090888 99381430 c.2224G>A p.V742I Substitution - Missense hom 38 7:55174761-55174761 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 51 ENSP00000275493.2:p.Val742Ile ENST00000275493.6:c.2224G>A 7:g.55174761G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166432 1166432 1078746 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51815927 COSM24971 133219942 c.2378T>C p.L793P Substitution - Missense hom 38 7:55191762-55191762 + - PATHOGENIC .97813 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 59 ENSP00000415559.1:p.Leu793Pro ENST00000455089.5:c.2378T>C 7:g.55191762T>C EGFR ENST00000275493.6 3633 3236 1696878 1696878 1605006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22674612 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345362 2345362 2210034 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1167797 1167797 1080039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19057270 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469454 1469454 1393193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838547 1838547 1732648 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096302 2096302 1974366 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 916966 916966 834347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16052537 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205975 2205975 2074208 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1505435 1505435 1428304 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21422434 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025394 2025394 1907483 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676436 1676436 1589204 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2132035 2132035 2006098 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24429877 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000250 2000250 1885148 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618054 1618054 1536850 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1746649 1746649 1651625 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 80 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777244 1777244 1681247 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004119-T01-IM5 2720520 2579341 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 133208833 c.619C>T p.R207C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg207Cys ENST00000455089.5:c.619C>T 7:g.55154017C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2651873 2651873 2512013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 27257132 surgery - NOS recurrent 71 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1097467 1097467 1012131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 18090579 NS NS 45 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1160958 1160958 1073294 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 19002495 surgery-fixed primary 71 ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SW48 2302017 2167300 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 45 2786467 2643890 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51849884 COSM13192 99382863 c.2428G>A p.G810S Substitution - Missense 38 7:55181437-55181437 + - PATHOGENIC .98229 Reported in another cancer sample as somatic 30115035 surgery-fixed NS ENSP00000275493.2:p.Gly810Ser ENST00000275493.6:c.2428G>A 7:g.55181437G>A EGFR ENST00000275493.6 3633 3236 1594565 1594565 1515533 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891243 1891243 1780612 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103805 1103805 1018057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 IR3T 897723 815346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15118125 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136868 1136868 1049432 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891242 1891242 1780611 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239177 2239177 2106709 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 56 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592987 1592987 1513913 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239187 2239187 2106719 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 48 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891238 1891238 1780607 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875377 1875377 1765960 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD_E01419 1765148 1669468 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 51 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009162 2009162 1891896 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1231316 1231316 1143106 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897830 897830 815452 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450930 1450930 1375073 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 51 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043860 1043860 960201 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1931643 1931643 1818933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1592988 1592988 1513914 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2009165 2009165 1891899 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2616330 2616330 2476816 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26118982 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1429328 1429328 1338779 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226865 2226865 2094600 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875343 1875343 1765926 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983756 1983756 1869992 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1031900 1031900 948691 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17085664 NS recurrent ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1075005 1075005 990259 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1991298 1991298 1876633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1434021 1434021 1343436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2027352 2027352 1909420 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 58 ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895066 1895066 1783758 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 G73 1179731 1091693 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51780730 COSM22940 132551401 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 58 ENSP00000395243.3:p.Arg731His ENST00000454757.6:c.2192G>A 7:g.55181336G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980064 1980064 1866307 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 67 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879513 1879513 1770015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1981020 1981020 1867256 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302269 1302269 1213320 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1098856 1098856 1013448 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899348 899348 816960 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1860430 1860430 1751371 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1738892 1738892 1644723 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0001296-T02-IM5 2719406 2578227 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28481359 NS metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1493285 1493285 1416275 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20871266 fine needle aspirate metastasis 77 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1052727 1052727 968798 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 99377339 c.2239_2240delinsCC p.L747P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 17368623 NS NS ENSP00000275493.2:p.Leu747Pro ENST00000275493.6:c.2239_2240delinsCC 7:g.55174776_55174777delinsCC EGFR ENST00000275493.6 3633 3236 2076211 2076211 1955023 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24406864 surgery-fixed primary 32 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2862239 2862239 2717429 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25969368 surgery-fixed primary ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1734962 1734962 1640906 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 132549396 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 64 ENSP00000395243.3:p.Pro803Leu ENST00000454757.6:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675373 2675373 2534647 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767379 COSM85894 132557468 c.2392G>A p.V798I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000395243.3:p.Val798Ile ENST00000454757.6:c.2392G>A 7:g.55191776G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S001005 1027699 944675 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2733218 2733218 2591971 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 42 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 1453434 1453434 1377467 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1456554 1456554 1380529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1083998 1083998 999163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17785547 surgery fresh/frozen primary 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891172 1891172 1780541 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1816951 1816951 1716119 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-08-0380-01 1910239 1798530 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779162 COSM21689 133203297 c.1652C>T p.P551L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 74 ENSP00000415559.1:p.Pro551Leu ENST00000455089.5:c.1652C>T 7:g.55165344C>T EGFR ENST00000275493.6 3633 3236 2226920 2226920 2094655 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2675011 2675011 2534306 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29110841 surgery - NOS metastasis 49 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1884054 1884054 1773943 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23495083 fixed - NOS metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2552452 2552452 2413893 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27553514 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2131914 2131914 2005977 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24376723 surgery-fixed primary ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481257 1481257 1404886 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004491-T01-IM5 2720890 2579711 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28481359 surgery - NOS primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098816 1098816 1013408 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1481253 1481253 1404882 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1884053 1884053 1773942 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23495083 fixed - NOS metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032225 2032225 1913696 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098876 1098876 1013468 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2476320 2476320 2339088 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 26870223 fine needle aspirate metastasis 48 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2096279 2096279 1974343 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 WG05T 2653265 2513392 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS primary 58.29 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899322 899322 816934 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226907 2226907 2094642 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891264 1891264 1780633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064712 2064712 1944789 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1075912 1075912 991166 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659803 2659803 2519961 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891272 1891272 1780641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 911622 911622 829105 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862722 2862722 2717885 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891258 1891258 1780627 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875792 1875792 1766375 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1549839 1549839 1471944 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 77 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1789322 1789322 1692726 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1789321 1789321 1692725 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897805 897805 815427 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043855 1043855 960196 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372584 2372584 2235377 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895140 1895140 1783832 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920163 920163 837243 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592976 1592976 1513902 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51792805 COSM13005 132549057 c.2183A>T p.H728L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.His728Leu ENST00000454757.6:c.2183A>T 7:g.55181327A>T EGFR ENST00000275493.6 3633 3236 P-0001296-T02-IM5 2719406 2578227 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 28481359 NS metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1493285 1493285 1416275 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 20871266 fine needle aspirate metastasis 77 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1576802 1576802 1498243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 surgery - NOS primary 47 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879503 1879503 1770005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1593033 1593033 1513959 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51784752 COSM13199 99375727 c.2618G>A p.G873E Substitution - Missense 38 7:55191867-55191867 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Gly873Glu ENST00000275493.6:c.2618G>A 7:g.55191867G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668448 1668448 1581741 lung bronchus NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22526156 surgery-fixed primary 25 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675682 2675682 2534956 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 29100434 surgery - NOS recurrent ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CCRF-CEM 1760519 1665122 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51787208 COSM327142 132549881 c.3217G>A p.A1073T Substitution - Missense 38 7:55205336-55205336 + - NEUTRAL .10522 Reported in another cancer sample as somatic 22675565 cell-line NS ENSP00000395243.3:p.Ala1073Thr ENST00000454757.6:c.3217G>A 7:g.55205336G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2035481 2035481 1916843 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 24034463 pleural effusion recurrent 74 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980070 1980070 1866313 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 64 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1914889 1914889 1802891 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214565 2214565 2082689 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046034 2046034 1926329 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345471 2345471 2210143 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770699 1770699 1674939 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1932131 1932131 1819404 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23632273 surgery fresh/frozen metastasis ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 OX-CO-2_R3_Cetux 2841378 2696927 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 132562107 c.1256C>T p.S419L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000395243.3:p.Ser419Leu ENST00000454757.6:c.1256C>T 7:g.55160231C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659762 2659762 2519920 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879551 1879551 1770053 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1921926 1921926 1809244 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2265124 2265124 2132028 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994671 cerebrospinal fluid metastasis 36 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081820 2081820 1960242 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481317 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096083 2096083 1974147 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680697 2680697 2539970 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120929 1120929 1034085 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887431 1887431 1777103 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014078 1014078 931252 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1967527 1967527 1854019 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23807543 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2033585 2033585 1915034 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24137397 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2115444 2115444 1989688 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23915069 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1113036 1113036 1026537 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18458038 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014257 1014257 931431 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667702 1667702 1580995 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664353 2664353 2524419 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed primary 44 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966328 1966328 1852821 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2131914 2131914 2005977 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24376723 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226144 2226144 2093879 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2245037 2245037 2112313 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096007 2096007 1974071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493334 1493334 1416324 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618765 1618765 1537517 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637631 2637631 2498004 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 surgery - NOS primary 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444788 1444788 1369031 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1835512 1835512 1730544 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23242440 NS NS 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1993865 1993865 1879121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23892415 surgery-fixed metastasis 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878854 2878854 2733369 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27368130 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937578 1937578 1824512 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1355104 1355104 1265199 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047770 2047770 1928042 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656130 1656130 1570787 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21311943 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914930 1914930 1802932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083088 2083088 1961509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24300726 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965820 1965820 1852313 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675161 2675161 2534435 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766284 COSM28512 132550675 c.2095A>G p.I699V Substitution - Missense 38 7:55174767-55174767 + - PATHOGENIC .99591 Reported in another cancer sample as somatic 29075127 surgery fresh/frozen NS ENSP00000395243.3:p.Ile699Val ENST00000454757.6:c.2095A>G 7:g.55174767A>G EGFR ENST00000275493.6 3633 3236 2644121 2644121 2504408 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525693 2525693 2387882 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551558 1551558 1473663 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430057 1430057 1339475 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2559140 2559140 2420564 thymus NS NS NS thymic_carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27731926 surgery-fixed NS 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095959 2095959 1974023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469421 1469421 1393160 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2141452 2141452 2010670 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24636848 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637116 1637116 1553164 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444765 1444765 1369008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1213657 1213657 1125524 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18978556 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1295790 1295790 1206862 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692934 surgery - NOS primary 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549121 2549121 2410576 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014118 1014118 931292 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2271435 2271435 2138062 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25257380 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014077 1014077 931251 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1526361 1526361 1448729 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21623281 surgery - NOS NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105790 2105790 1983828 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105792 2105792 1983830 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878856 2878856 2733371 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27368130 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680708 2680708 2539981 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547810 1547810 1469932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095919 2095919 1973983 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1196959 1196959 1108854 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777424 1777424 1681427 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965903 1965903 1852396 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346536 2346536 2211199 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264232 2264232 2131216 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777210 1777210 1681213 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026241 2026241 1908330 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838644 1838644 1732745 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345598 2345598 2210270 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1235132 1235132 1146918 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770645 1770645 1674885 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777418 1777418 1681421 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329263 1329263 1239748 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551550 1551550 1473655 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278198 1278198 1189496 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000235 2000235 1885133 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637161 1637161 1553209 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142063 2142063 2011281 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2822952 2822952 2678811 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29807405 surgery - NOS NS 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105791 2105791 1983829 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838730 1838730 1732831 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770587 1770587 1674827 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875795 1875795 1766378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1981021 1981021 1867257 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594602 1594602 1515570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594600 1594600 1515568 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983711 1983711 1869947 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897807 897807 815429 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1075001 1075001 990255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 50 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895146 1895146 1783838 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593010 1593010 1513936 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924347 924347 841122 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990898 1990898 1876233 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875367 1875367 1765950 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602817 1602817 1522153 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1575154 1575154 1496595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1000049 1000049 917272 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-RT-S01856 1765145 1669465 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1083812 1083812 998977 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345422 2345422 2210094 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029000 2029000 1910882 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081997 2081997 1960419 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24443522 surgery - NOS NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551555 1551555 1473660 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205967 2205967 2074200 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148616 2148616 2017746 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246679 1246679 1158358 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2839891 2839891 2695657 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28961830 circulating tumour recurrent 36 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2110150 2110150 1986502 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24563335 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027790 2027790 1909693 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096212 2096212 1974276 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2840307 2840307 2695867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 31632838 circulating tumour recurrent 68 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778770 2778770 2636824 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479954 1479954 1403614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879529 1879529 1770031 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891310 1891310 1780679 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879525 1879525 1770027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879543 1879543 1770045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879571 1879571 1770073 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2629460 2629460 2489844 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51769863 COSM1090888 132554400 c.2089G>A p.V697I Substitution - Missense 38 7:55174761-55174761 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 26317919 surgery-fixed NS 63 ENSP00000395243.3:p.Val697Ile ENST00000454757.6:c.2089G>A 7:g.55174761G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891299 1891299 1780668 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 TCGA-02-0007-01 1910125 1798416 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 99378725 c.787A>C p.T263P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 42 ENSP00000275493.2:p.Thr263Pro ENST00000275493.6:c.787A>C 7:g.55154050A>C EGFR ENST00000275493.6 3633 3236 1174335 1174335 1086354 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1886121 1886121 1776007 lung left_upper_lobe NS NS carcinoma large_cell_neuroendocrine_carcinoma mixed NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23518631 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2290967 2290967 2157032 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2151310 2151310 2020354 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24758910 NS NS 56 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1141186 1141186 1053634 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 18785203 surgery-fixed NS 67 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MBC550 2807318 2664022 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51859563 COSM6910210 133204470 c.2374G>A p.D792N Substitution - Missense 38 7:55191758-55191758 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 31340200 surgery - NOS NS ENSP00000415559.1:p.Asp792Asn ENST00000455089.5:c.2374G>A 7:g.55191758G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1047008 1047008 963239 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1661392 1661392 1575007 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22483783 surgery-fixed NS 61 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-D1-A174-01 1783520 1687519 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51769863 COSM1090888 132554400 c.2089G>A p.V697I Substitution - Missense hom 38 7:55174761-55174761 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 51 ENSP00000395243.3:p.Val697Ile ENST00000454757.6:c.2089G>A 7:g.55174761G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2701198 2701198 2560102 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing_non_differentiated NS n COSV51769863 COSM1090888 132554400 c.2089G>A p.V697I Substitution - Missense het 38 7:55174761-55174761 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 28581676 surgery-fixed NS 48 ENSP00000395243.3:p.Val697Ile ENST00000454757.6:c.2089G>A 7:g.55174761G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1052727 1052727 968798 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 132550443 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 17368623 NS NS ENSP00000395243.3:p.Leu702Pro ENST00000454757.6:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR ENST00000275493.6 3633 3236 1500172 1500172 1423051 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM86998 178379356 c.? p.R776C Substitution - Missense + - Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000275493.2:p.Arg776Cys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924777 924777 841550 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51863722 COSM13560 133221958 c.1736G>T p.C579F Substitution - Missense het 38 7:55165428-55165428 + - PATHOGENIC .99905 Reported in another cancer sample as somatic 16133419 NS NS ENSP00000415559.1:p.Cys579Phe ENST00000455089.5:c.1736G>T 7:g.55165428G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2734338 2734338 2593065 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 29731638 surgery - NOS NS 52 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194725 1194725 1106620 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 132550339 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Ala244Asp ENST00000454757.6:c.731C>A 7:g.55154129C>A EGFR ENST00000275493.6 3633 3236 P-0002085-T01-IM3 2718386 2577207 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767827 COSM1235378 99401095 c.2560A>T p.T854S Substitution - Missense het 38 7:55191809-55191809 + - PATHOGENIC .98595 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr854Ser ENST00000275493.6:c.2560A>T 7:g.55191809A>T EGFR ENST00000275493.6 3633 3236 P-0002085-T01-IM3 2718386 2577207 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 SJHGG120_D 2307435 2172639 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 24705251 surgery - NOS NS 12 ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895066 1895066 1783758 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110454 1110454 1024332 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891271 1891271 1780640 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2214725 2214725 2082849 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25047674 surgery - NOS NS 52 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983760 1983760 1869996 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1434022 1434022 1343437 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983818 1983818 1870054 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895078 1895078 1783770 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064716 2064716 1944793 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899353 899353 816965 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098863 1098863 1013455 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110453 1110453 1024331 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KTA-7 946051 862577 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2629460 2629460 2489844 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51769863 COSM1090888 99381430 c.2224G>A p.V742I Substitution - Missense 38 7:55174761-55174761 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 26317919 surgery-fixed NS 63 ENSP00000275493.2:p.Val742Ile ENST00000275493.6:c.2224G>A 7:g.55174761G>A EGFR ENST00000275493.6 3633 3236 1469797 1469797 1393536 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2153172 2153172 2022182 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469808 1469808 1393547 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1661837 1661837 1575450 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22487432 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469799 1469799 1393538 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2476860 2476860 2339629 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879558 1879558 1770060 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1576804 1576804 1498245 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 surgery - NOS primary 64 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1576801 1576801 1498242 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 62 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004496-T01-IM5 2720895 2579716 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891324 1891324 1780693 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592988 1592988 1513914 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1083998 1083998 999163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17785547 surgery fresh/frozen primary 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899348 899348 816960 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860430 1860430 1751371 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001296-T02-IM5 2719406 2578227 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28481359 NS metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1456554 1456554 1380529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1981020 1981020 1867256 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429328 1429328 1338779 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1237665 1237665 1149412 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1965913 1965913 1852406 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1075001 1075001 990255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 50 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875795 1875795 1766378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924347 924347 841122 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602817 1602817 1522153 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1000049 1000049 917272 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895146 1895146 1783838 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1594602 1594602 1515570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LUAD-RT-S01856 1765145 1669465 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897807 897807 815429 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983711 1983711 1869947 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1981021 1981021 1867257 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1575154 1575154 1496595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983756 1983756 1869992 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302269 1302269 1213320 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891172 1891172 1780541 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2616330 2616330 2476816 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26118982 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009165 2009165 1891899 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226865 2226865 2094600 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875343 1875343 1765926 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098856 1098856 1013448 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1738892 1738892 1644723 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1493285 1493285 1416275 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20871266 fine needle aspirate metastasis 77 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453434 1453434 1377467 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2426845 2426845 2289766 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1667695 1667695 1580988 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2402476 2402476 2265332 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 79 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2465701 2465701 2328532 lung right_lower_lobe NS NS carcinoma adenocarcinoma transformed_to_squamous_cell_carcinoma NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26746366 surgery - NOS recurrent 79 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 NPC0001PT00243T00243 2857340 2712640 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00190T00190 2857342 2712642 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166445 1166445 1078759 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 81 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895132 1895132 1783824 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1884152 1884152 1774039 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1102407 1102407 1016659 lung right_upper_lobe NS NS other hyperplasia NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18208799 surgery-fixed NS 47 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778633 2778633 2636687 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS n COSV51820767 COSM53288 132556058 c.2219C>T p.T740I Substitution - Missense 38 7:55181363-55181363 + - PATHOGENIC .9109 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000395243.3:p.Thr740Ile ENST00000454757.6:c.2219C>T 7:g.55181363C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924330 924330 841105 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089138 1089138 1004092 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429252 1429252 1338703 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895164 1895164 1783856 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891197 1891197 1780566 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594554 1594554 1515522 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983724 1983724 1869960 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891259 1891259 1780628 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-NYU1142 1765136 1669456 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990913 1990913 1876248 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077333 1077333 992587 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231318 1231318 1143108 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1197355 1197355 1109250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983738 1983738 1869974 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897815 897815 815437 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1200921 1200921 1112811 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2579649 2579649 2440986 NS NS NS NS malignant_melanoma NS NS NS n COSV51781835 COSM174732 99379122 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000275493.2:p.Glu114Lys ENST00000275493.6:c.340G>A 7:g.55143404G>A EGFR ENST00000275493.6 3633 3236 1551565 1551565 1473670 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM53179 178383575 c.? p.V834L Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Val834Leu EGFR ENST00000275493.6 3633 3236 1551502 1551502 1473607 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2046173 2046173 1926468 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1593010 1593010 1513936 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875367 1875367 1765950 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1594600 1594600 1515568 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1990898 1990898 1876233 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895137 1895137 1783829 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1517068 1517068 1439662 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089604 1089604 1004551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862725 2862725 2717888 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226910 2226910 2094645 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S001067 1027687 944663 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 133206822 c.652A>C p.T218P Substitution - Missense hom 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Thr218Pro ENST00000455089.5:c.652A>C 7:g.55154050A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 122 1881682 1771833 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23391413 surgery-fixed NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2629466 2629466 2489850 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51797168 COSM87247 133235835 c.2452G>A p.G818S Substitution - Missense 38 7:55191836-55191836 + - PATHOGENIC .94673 Reported in another cancer sample as somatic 26317919 surgery-fixed NS 72 ENSP00000415559.1:p.Gly818Ser ENST00000455089.5:c.2452G>A 7:g.55191836G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SJHGG120_D 2307435 2172639 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 24705251 surgery - NOS NS 12 ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 1770661 1770661 1674901 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965882 1965882 1852375 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731385 1731385 1637351 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22457323 NS NS 65 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1789304 1789304 1692708 lung NS NS NS carcinoma NS NS NS n COSV51765252 COSM13009 132568674 c.1991A>G p.E664G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000395243.3:p.Glu664Gly ENST00000454757.6:c.1991A>G 7:g.55173985A>G EGFR ENST00000275493.6 3633 3236 2106534 2106534 1984397 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547816 1547816 1469938 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 pleural effusion recurrent 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777285 1777285 1681288 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336835 1336835 1247220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1517359 1517359 1439743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21610522 cerebrospinal fluid metastasis 40 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515242 1515242 1437852 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680690 2680690 2539963 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 46 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1162653 1162653 1074985 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51796944 COSM28537 99382129 c.2560A>G p.T854A Substitution - Missense het 38 7:55191809-55191809 + - PATHOGENIC .9858 Reported in another cancer sample as somatic 19010870 surgery - NOS metastasis 69 ENSP00000275493.2:p.Thr854Ala ENST00000275493.6:c.2560A>G 7:g.55191809A>G EGFR ENST00000275493.6 3633 3236 1154311 1154311 1066647 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18957054 surgery-fixed NS 82 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838648 1838648 1732749 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246630 1246630 1158309 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638731 1638731 1554730 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637153 1637153 1553201 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246634 1246634 1158313 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026243 2026243 1908332 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046071 2046071 1926366 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1483084 1483084 1406713 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21163115 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777272 1777272 1681275 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964322 1964322 1850857 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914973 1914973 1802975 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141279 1141279 1053727 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230456 1230456 1142270 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163039 2163039 2031623 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777282 1777282 1681285 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SNU-638 2807650 2664351 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51777111 COSM33725 132559461 c.2474A>G p.H825R Substitution - Missense 38 7:55191858-55191858 + - PATHOGENIC .97748 Reported in another cancer sample as somatic 24807215 cell-line NS 48 ENSP00000395243.3:p.His825Arg ENST00000454757.6:c.2474A>G 7:g.55191858A>G EGFR ENST00000275493.6 3633 3236 2421219 2421219 2284141 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965875 1965875 1852368 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1715980 1715980 1623542 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22760226 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1661837 1661837 1575450 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22487432 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1668657 1668657 1581949 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22523351 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2867547 2867547 2722582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 32441866 bronchoalveolar lavage fluid NS 85 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618652 1618652 1537404 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937522 1937522 1824456 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2115442 2115442 1989686 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23915069 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278181 1278181 1189479 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240545 2240545 2108076 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25227801 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476860 2476860 2339629 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279048 1279048 1190344 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed primary 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637246 1637246 1553294 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246625 1246625 1158304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179107 1179107 1091069 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19185949 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1029021 1029021 945892 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17075123 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 21 1596831 1517544 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20093389 surgery fresh/frozen NS 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106539 2106539 1984402 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618722 1618722 1537474 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 82 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549149 2549149 2410604 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965894 1965894 1852387 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027830 2027830 1909733 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264158 2264158 2131142 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2426845 2426845 2289766 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2437321 2437321 2300171 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23211219 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279084 1279084 1190380 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed primary 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120944 1120944 1034100 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu861Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042908 1042908 959249 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895166 1895166 1783858 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1627725 1627725 1544637 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302268 1302268 1213319 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592998 1592998 1513924 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862719 2862719 2717882 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1074879 1074879 990133 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17505415 surgery fresh/frozen primary 71 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875352 1875352 1765935 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1981019 1981019 1867255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659800 2659800 2519958 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009152 2009152 1891886 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2277204 2277204 2143736 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25328676 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302285 1302285 1213336 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2840305 2840305 2695865 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31632838 surgery - NOS NS 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625560 2625560 2485972 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 51 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895105 1895105 1783797 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862708 2862708 2717871 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372586 2372586 2235379 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 907089 907089 824601 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895130 1895130 1783822 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891181 1891181 1780550 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895143 1895143 1783835 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103629 1103629 1017881 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 53 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2840788 2840788 2696348 prostate NS NS NS carcinoma NS NS NS n COSV51785413 COSM1176673 132555528 c.620G>A p.R207H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 31874108 surgery-fixed metastasis ENSP00000395243.3:p.Arg207His ENST00000454757.6:c.620G>A 7:g.55154018G>A EGFR ENST00000275493.6 3633 3236 2479713 2479713 2342459 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51780877 COSM26717 99375410 c.2579A>T p.K860I Substitution - Missense het 38 7:55191828-55191828 + - PATHOGENIC .95726 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000275493.2:p.Lys860Ile ENST00000275493.6:c.2579A>T 7:g.55191828A>T EGFR ENST00000275493.6 3633 3236 1043129 1043129 959470 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 31 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879484 1879484 1769986 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879550 1879550 1770052 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 HN_62995 1560583 1482033 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825459 COSM122789 133214097 c.1288A>G p.I430V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Reported in another cancer sample as somatic 21798893 surgery fresh/frozen primary ENSP00000415559.1:p.Ile430Val ENST00000455089.5:c.1288A>G 7:g.55160263A>G EGFR ENST00000275493.6 3633 3236 1879490 1879490 1769992 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1444718 1444718 1368961 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637128 1637128 1553176 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842960 1842960 1736208 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345520 2345520 2210192 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105802 2105802 1983840 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680555 2680555 2539828 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 32 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120941 1120941 1034097 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914896 1914896 1802898 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2238967 2238967 2106499 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25137181 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842905 1842905 1736164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23261229 surgery-fixed NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887420 1887420 1777092 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2136623 2136623 2006174 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777228 1777228 1681231 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345543 2345543 2210215 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345403 2345403 2210075 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838649 1838649 1732750 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667695 1667695 1580988 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731379 1731379 1637345 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22457323 NS NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345600 2345600 2210272 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1517405 1517405 1439789 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21610522 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118434 2118434 1992669 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469359 1469359 1393098 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591020 1591020 1512136 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402476 2402476 2265332 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096029 2096029 1974093 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240676 2240676 2108207 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 81 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264210 2264210 2131194 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777284 1777284 1681287 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014265 1014265 931439 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106532 2106532 1984395 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618678 1618678 1537430 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444727 1444727 1368970 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A103-T-S25 2757418 2616003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2113070 2113070 1987331 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 132548474 c.2117C>T p.T706I Substitution - Missense het 38 7:55174789-55174789 + - PATHOGENIC .99151 Reported in another cancer sample as somatic 24595526 surgery-fixed NS ENSP00000395243.3:p.Thr706Ile ENST00000454757.6:c.2117C>T 7:g.55174789C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00207T00207 2857359 2712659 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1140942 1140942 1053390 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448998 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096017 2096017 1974081 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136883 1136883 1049447 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479941 1479941 1403601 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1093894 1093894 1008596 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18061305 pleural effusion NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 HCC4011 2776306 2634442 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29681454 NS NS 53 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1075000 1075000 990254 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891289 1891289 1780658 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064717 2064717 1944794 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089134 1089134 1004088 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 11-18-ER1-7 1731373 1637339 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22815900 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990894 1990894 1876229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1966253 1966253 1852746 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23800712 fixed - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2594470 2594470 2455346 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 28178168 surgery - NOS recurrent 67 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2402487 2402487 2265343 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 78 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1822551 1822551 1720945 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23198868 fixed - NOS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1168013 1168013 1080255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875355 1875355 1765938 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895162 1895162 1783854 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920151 920151 837231 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 81 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P92 1179743 1091705 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 52 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043865 1043865 960206 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1000052 1000052 917275 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043873 1043873 960214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891227 1891227 1780596 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 911618 911618 829101 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453418 1453418 1377451 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1000050 1000050 917273 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1074949 1074949 990203 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 71 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891188 1891188 1780557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1705345 1705345 1613329 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51769815 COSM249886 99403766 c.2096C>T p.P699L Substitution - Missense 38 7:55173955-55173955 + - PATHOGENIC .97389 Reported in another cancer sample as somatic 22722798 surgery - NOS recurrent 71 ENSP00000275493.2:p.Pro699Leu ENST00000275493.6:c.2096C>T 7:g.55173955C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895170 1895170 1783862 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 946819 946819 863342 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51803771 COSM14068 132563495 c.2173G>A p.D725N Substitution - Missense 38 7:55181317-55181317 + - PATHOGENIC .97623 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000395243.3:p.Asp725Asn ENST00000454757.6:c.2173G>A 7:g.55181317G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1235125 1235125 1146911 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 58 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2539013 2539013 2400608 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 26749488 NS metastasis 57 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1590011 1590011 1511165 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21995391 surgery-fixed recurrent 55 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1980071 1980071 1866314 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 61 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2076211 2076211 1955023 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24406864 surgery-fixed primary 32 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602805 1602805 1522141 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001300-T02-IM5 2719407 2578228 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429294 1429294 1338745 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2027345 2027345 1909413 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 40 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2264434 2264434 2131418 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1602599 1602599 1521935 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 22082647 surgery-fixed NS 45 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1515259 1515259 1437869 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493329 1493329 1416319 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096160 2096160 1974224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2675411 2675411 2534685 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29100434 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264087 2264087 2131071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444775 1444775 1369018 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EXTERN_MELA_20140526_088 2839362 2695128 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 133208246 c.1033C>A p.Q345K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000415559.1:p.Gln345Lys ENST00000455089.5:c.1033C>A 7:g.55156793C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0125-01 1910168 1798459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 64 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1141186 1141186 1053634 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 18785203 surgery-fixed NS 67 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1648542 1648542 1563497 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450876 1450876 1375019 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 56 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891199 1891199 1780568 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2421205 2421205 2284127 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535032 1535032 1457367 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1835511 1835511 1730543 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23242440 NS NS 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676426 1676426 1589194 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047779 2047779 1928051 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705475 1705475 1613381 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1196950 1196950 1108845 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174315 1174315 1086334 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264260 2264260 2131244 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1047869 1047869 964098 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17228019 surgery - NOS NS 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475394 1475394 1399093 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1590998 1590998 1512114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777416 1777416 1681419 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1201402 1201402 1113292 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19357847 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770599 1770599 1674839 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1110727 1110727 1024605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18325048 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228760 2228760 2096472 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24956168 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2372833 2372833 2235626 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25904052 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983094 983094 898812 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618847 1618847 1537599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777211 1777211 1681214 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587282 1587282 1508453 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777365 1777365 1681368 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618654 1618654 1537406 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2594470 2594470 2455346 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28178168 surgery - NOS recurrent 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246673 1246673 1158352 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1610402 1610402 1529642 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22142557 pleural effusion NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142076 2142076 2011294 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551565 1551565 1473670 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290948 2290948 2157013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096078 2096078 1974142 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045984 2045984 1926279 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770694 1770694 1674934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095909 2095909 1973973 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095890 2095890 1973954 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174294 1174294 1086313 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2406824 2406824 2269704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 42 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076971 2076971 1955720 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1196956 1196956 1108851 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637146 1637146 1553194 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345427 2345427 2210099 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2788067 2788067 2645485 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29308976 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345501 2345501 2210173 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372587 2372587 2235380 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1046998 1046998 963229 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372595 2372595 2235388 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1625793 1625793 1543017 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302246 1302246 1213297 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1610923 1610923 1530151 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22157931 surgery-fixed metastasis 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1107242 1107242 1021154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 G73 1179731 1091693 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 58 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2205969 2205969 2074202 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345528 2345528 2210200 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591054 1591054 1512170 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469457 1469457 1393196 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914898 1914898 1802900 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345551 2345551 2210223 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2559411 2559411 2420835 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24158231 surgery fresh/frozen NS 45 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2032069 2032069 1913540 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24103528 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402520 2402520 2265376 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264434 2264434 2131418 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2245048 2245048 2112324 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246639 1246639 1158318 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173404 1173404 1085488 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148614 2148614 2017744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637124 1637124 1553172 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1434745 1434745 1344103 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20813423 surgery - NOS primary 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535043 1535043 1457378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430036 1430036 1339454 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237697 1237697 1149444 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345474 2345474 2210146 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345515 2345515 2210187 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656135 1656135 1570792 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21311943 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336423 1336423 1246808 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20430469 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237666 1237666 1149413 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 30 1596840 1517553 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20093389 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637704 2637704 2498077 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 circulating tumour recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770749 1770749 1674989 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045965 2045965 1926260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246707 1246707 1158386 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345486 2345486 2210158 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027793 2027793 1909696 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345530 2345530 2210202 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346537 2346537 2211200 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230491 1230491 1142305 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887364 1887364 1777036 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430032 1430032 1339450 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329264 1329264 1239749 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547826 1547826 1469948 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 fine needle aspirate recurrent 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279039 1279039 1190335 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed metastasis 48 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459520 1459520 1383463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2437323 2437323 2300173 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23211219 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1673293 1673293 1586347 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22225786 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522879 1522879 1445251 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983163 983163 898881 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777310 1777310 1681313 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895119 1895119 1783811 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1738960 1738960 1644791 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110451 1110451 1024329 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1445182 1445182 1369425 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20682976 autopsy - NOS metastasis 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887371 1887371 1777043 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476863 2476863 2339632 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2582951 2582951 2444206 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28024692 surgery - NOS primary 43 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549117 2549117 2410572 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1673291 1673291 1586345 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22225786 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-02-0016-01 1910129 1798420 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 50 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429295 1429295 1338746 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1435997 1435997 1345276 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen primary 49 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891255 1891255 1780624 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891237 1891237 1780606 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891184 1891184 1780553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2817999 2817999 2674298 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31422893 pleural effusion metastasis 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1038996 1038996 955573 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226874 2226874 2094609 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-86-8075-01 1914090 1802372 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1672196 1672196 1585384 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21917678 fine needle aspirate NS 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2078357 2078357 1957076 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24314215 pleural effusion NS 88 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453414 1453414 1377447 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899334 899334 816946 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891260 1891260 1780629 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983762 1983762 1869998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1434024 1434024 1343439 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593011 1593011 1513937 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860421 1860421 1751362 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631952 1631952 1548822 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875351 1875351 1765934 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891225 1891225 1780594 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226919 2226919 2094654 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897829 897829 815451 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1789318 1789318 1692722 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064713 2064713 1944790 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1517069 1517069 1439663 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064711 2064711 1944788 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 45 2786467 2643890 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51849884 COSM13192 132555587 c.2293G>A p.G765S Substitution - Missense 38 7:55181437-55181437 + - PATHOGENIC .98229 Reported in another cancer sample as somatic 30115035 surgery-fixed NS ENSP00000395243.3:p.Gly765Ser ENST00000454757.6:c.2293G>A 7:g.55181437G>A EGFR ENST00000275493.6 3633 3236 2163017 2163017 2031601 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 3695 915981 833380 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51787507 COSM13188 133213942 c.2146G>A p.D716N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000415559.1:p.Asp716Asn ENST00000455089.5:c.2146G>A 7:g.55174818G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 907082 907082 824594 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239187 2239187 2106719 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 48 ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1881382 1881382 1771533 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1141191 1141191 1053639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 18785203 autopsy-fixed NS 78 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-GE101-T1 2869805 2724802 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51822498 COSM3266565 132578509 c.782C>T p.S261L Substitution - Missense 38 7:55155857-55155857 + - PATHOGENIC .98807 Reported in another cancer sample as somatic 26950094 surgery - NOS NS 81 ENSP00000395243.3:p.Ser261Leu ENST00000454757.6:c.782C>T 7:g.55155857C>T EGFR ENST00000275493.6 3633 3236 1179118 1179118 1091080 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 19185949 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1046998 1046998 963229 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891199 1891199 1780568 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1107242 1107242 1021154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18334834 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2076211 2076211 1955023 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24406864 surgery-fixed primary 32 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2372587 2372587 2235380 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602805 1602805 1522141 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1024780 1024780 941757 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1040049 1040049 956626 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17180521 surgery - NOS recurrent 57 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980061 1980061 1866304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 69 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-NYU1142 1765136 1669456 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 72 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879568 1879568 1770070 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879507 1879507 1770009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778771 2778771 2636825 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2147905 2147905 2017048 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 45 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1648542 1648542 1563497 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1625793 1625793 1543017 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0001300-T02-IM5 2719407 2578228 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302246 1302246 1213297 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2372595 2372595 2235388 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2027345 2027345 1909413 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 40 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1610923 1610923 1530151 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22157931 surgery-fixed metastasis 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1429294 1429294 1338745 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450876 1450876 1375019 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 56 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1179663 1179663 1091625 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983097 983097 898815 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120943 1120943 1034099 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 411 898398 816010 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226772 2226772 2094507 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51782925 COSM24267 132550443 c.2104_2105delinsCC p.L702P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu702Pro ENST00000454757.6:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879482 1879482 1769984 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879545 1879545 1770047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 23 2570184 2431481 skin forearm NS NS adnexal_tumour sebaceous_adenoma NS NS n COSV51767182 COSM27110 132554778 c.2221G>A p.V741M Substitution - Missense 38 7:55181365-55181365 + - PATHOGENIC .97319 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 67 ENSP00000395243.3:p.Val741Met ENST00000454757.6:c.2221G>A 7:g.55181365G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625578 2625578 2485990 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 74 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2214725 2214725 2082849 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25047674 surgery - NOS NS 52 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899353 899353 816965 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1102407 1102407 1016659 lung right_upper_lobe NS NS other hyperplasia NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18208799 surgery-fixed NS 47 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983760 1983760 1869996 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895078 1895078 1783770 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1166445 1166445 1078759 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 81 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983818 1983818 1870054 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895132 1895132 1783824 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1098863 1098863 1013455 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891271 1891271 1780640 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1434022 1434022 1343437 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2064716 2064716 1944793 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1110453 1110453 1024331 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1110454 1110454 1024332 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1884152 1884152 1774039 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0237-01 1910211 1798502 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense hom 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 75 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 2471442 2471442 2334228 skin NS NS NS malignant_melanoma NS NS NS n COSV51836136 COSM5574310 99396611 c.2899G>A p.E967K Substitution - Missense 38 7:55200366-55200366 + - PATHOGENIC .99379 Reported in another cancer sample as somatic 25452114 surgery fresh/frozen metastasis 55 ENSP00000275493.2:p.Glu967Lys ENST00000275493.6:c.2899G>A 7:g.55200366G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479953 1479953 1403613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767182 COSM27110 133210338 c.2221G>A p.V741M Substitution - Missense 38 7:55181365-55181365 + - PATHOGENIC .97319 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Val741Met ENST00000455089.5:c.2221G>A 7:g.55181365G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675161 2675161 2534435 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766268 COSM13183 132550670 c.2090T>C p.V697A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Reported in another cancer sample as somatic 29075127 surgery fresh/frozen NS ENSP00000395243.3:p.Val697Ala ENST00000454757.6:c.2090T>C 7:g.55174762T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226910 2226910 2094645 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2476320 2476320 2339088 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 26870223 fine needle aspirate metastasis 48 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897818 897818 815440 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1197356 1197356 1109251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891186 1891186 1780555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042920 1042920 959261 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592997 1592997 1513923 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098811 1098811 1013403 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18186961 surgery - NOS primary 61 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1168008 1168008 1080250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231328 1231328 1143118 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593000 1593000 1513926 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897827 897827 815449 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1992084 1992084 1877401 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 84 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 914804 914804 832253 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-NYU1101 1765169 1669489 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 72 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891246 1891246 1780615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 984658 984658 900313 lung right_middle_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16619582 surgery-fixed primary 51 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875338 1875338 1765921 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1876991 1876991 1767553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077329 1077329 992583 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895093 1895093 1783785 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1202559 1202559 1114445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2579649 2579649 2440986 NS NS NS NS malignant_melanoma NS NS NS n COSV51781835 COSM174732 132552286 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000395243.3:p.Glu114Lys ENST00000454757.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-02-0007-01 1910125 1798416 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 132551880 c.652A>C p.T218P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 42 ENSP00000395243.3:p.Thr218Pro ENST00000454757.6:c.652A>C 7:g.55154050A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1094000 1094000 1008702 urinary_tract bladder NS NS carcinoma NS NS NS n COSV51816100 COSM13430 132569804 c.2380G>A p.A794T Substitution - Missense 38 7:55191764-55191764 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 17707060 surgery fresh/frozen NS ENSP00000395243.3:p.Ala794Thr ENST00000454757.6:c.2380G>A 7:g.55191764G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1989947 1989947 1875286 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51789625 COSM13197 132549922 c.2455G>A p.A819T Substitution - Missense hom 38 7:55191839-55191839 + - PATHOGENIC .9615 Reported in another cancer sample as somatic 23585556 surgery-fixed primary ENSP00000395243.3:p.Ala819Thr ENST00000454757.6:c.2455G>A 7:g.55191839G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592973 1592973 1513899 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51803771 COSM14068 132563495 c.2173G>A p.D725N Substitution - Missense 38 7:55181317-55181317 + - PATHOGENIC .97623 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Asp725Asn ENST00000454757.6:c.2173G>A 7:g.55181317G>A EGFR ENST00000275493.6 3633 3236 2226772 2226772 2094507 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51782925 COSM24267 99377339 c.2239_2240delinsCC p.L747P Substitution - Missense 38 7:55174776-55174777 + - Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu747Pro ENST00000275493.6:c.2239_2240delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001296-T02-IM5 2719406 2578227 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 28481359 NS metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1816951 1816951 1716119 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2675011 2675011 2534306 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29110841 surgery - NOS metastasis 49 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1576802 1576802 1498243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 surgery - NOS primary 47 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226920 2226920 2094655 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879503 1879503 1770005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1493285 1493285 1416275 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 20871266 fine needle aspirate metastasis 77 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00143T00143 2857358 2712658 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-156-tumor 2819056 2675355 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PC-7 946057 862583 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1242317 1242317 1154047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777111 COSM33725 133215620 c.2474A>G p.H825R Substitution - Missense hom 38 7:55191858-55191858 + - PATHOGENIC .97748 Reported in another cancer sample as somatic 19671738 surgery - NOS metastasis 56 ENSP00000415559.1:p.His825Arg ENST00000455089.5:c.2474A>G 7:g.55191858A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2555799 2555799 2417236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 26599269 surgery - NOS NS 58 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479943 1479943 1403603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2555799 2555799 2417236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 26599269 surgery - NOS NS 58 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592890 1592890 1513816 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51802602 COSM13181 133220811 c.2063C>T p.P688L Substitution - Missense 38 7:55174735-55174735 + - PATHOGENIC .99806 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Pro688Leu ENST00000455089.5:c.2063C>T 7:g.55174735C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2479713 2479713 2342459 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51780877 COSM26717 132548732 c.2444A>T p.K815I Substitution - Missense het 38 7:55191828-55191828 + - PATHOGENIC .95726 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000395243.3:p.Lys815Ile ENST00000454757.6:c.2444A>T 7:g.55191828A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 WG05T 2653265 2513392 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS primary 58.29 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1029330 1029330 946201 upper_aerodigestive_tract pharynx oropharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51789362 COSM13184 133232364 c.2101G>A p.E701K Substitution - Missense 38 7:55174773-55174773 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 17121883 surgery-fixed NS ENSP00000415559.1:p.Glu701Lys ENST00000455089.5:c.2101G>A 7:g.55174773G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1063627 1063627 979672 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875804 1875804 1766387 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077336 1077336 992590 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226892 2226892 2094627 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1573760 1573760 1495229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21982684 surgery fresh/frozen primary 76 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1074885 1074885 990139 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17505415 surgery fresh/frozen primary 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891337 1891337 1780706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042858 1042858 959199 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2479712 2479712 2342458 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226903 2226903 2094638 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302247 1302247 1213298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS 61 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110448 1110448 1024326 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372589 2372589 2235382 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1500182 1500182 1423061 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110452 1110452 1024330 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2073269 2073269 1952508 upper_aerodigestive_tract sinonasal_and_nasal_cavity NS NS carcinoma adenocarcinoma intestinal NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24338245 surgery-fixed NS 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668554 1668554 1581847 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983703 1983703 1869939 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983712 1983712 1869948 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 911624 911624 829107 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899323 899323 816935 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891167 1891167 1780536 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162653 1162653 1074985 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19010870 surgery - NOS metastasis 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990899 1990899 1876234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593033 1593033 1513959 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51784752 COSM13199 132549074 c.2483G>A p.G828E Substitution - Missense 38 7:55191867-55191867 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Gly828Glu ENST00000454757.6:c.2483G>A 7:g.55191867G>A EGFR ENST00000275493.6 3633 3236 1517359 1517359 1439743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM22420 178383004 c.? p.V843I Substitution - Missense + - Reported in another cancer sample as somatic 21610522 cerebrospinal fluid metastasis 40 ENSP00000275493.2:p.Val843Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005580-T01-IM5 2721973 2580794 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002085-T01-IM3 2718386 2577207 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767827 COSM1235378 132569177 c.2425A>T p.T809S Substitution - Missense het 38 7:55191809-55191809 + - PATHOGENIC .98595 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr809Ser ENST00000454757.6:c.2425A>T 7:g.55191809A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002085-T01-IM3 2718386 2577207 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-GE026-T1 2869747 2724744 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51789362 COSM13184 132574086 c.2101G>A p.E701K Substitution - Missense 38 7:55174773-55174773 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 26950094 surgery - NOS NS 74 ENSP00000395243.3:p.Glu701Lys ENST00000454757.6:c.2101G>A 7:g.55174773G>A EGFR ENST00000275493.6 3633 3236 2083100 2083100 1961521 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 24300726 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0185-01 1910194 1798485 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774819 COSM35840 133207029 c.1816G>A p.V606M Substitution - Missense het 38 7:55173014-55173014 + - PATHOGENIC .99458 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 54 ENSP00000415559.1:p.Val606Met ENST00000455089.5:c.1816G>A 7:g.55173014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC130 2439290 2302131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780429 COSM710350 133213787 c.2477C>T p.A826V Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .97911 Reported in another cancer sample as somatic 26164066 surgery-fixed metastasis ENSP00000415559.1:p.Ala826Val ENST00000455089.5:c.2477C>T 7:g.55191861C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 912470 912470 829962 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 15625347 NS NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625627 2625627 2486039 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51767687 COSM6191352 132547106 c.1612G>A p.A538T Substitution - Missense het 38 7:55165304-55165304 + - PATHOGENIC .98656 Reported in another cancer sample as somatic 26488212 surgery-fixed NS ENSP00000395243.3:p.Ala538Thr ENST00000454757.6:c.1612G>A 7:g.55165304G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 10 2570187 2431484 skin face NS NS adnexal_tumour other sebaceoma NS n COSV51768262 COSM26445 132550179 c.2165C>T p.A722V Substitution - Missense 38 7:55181309-55181309 + - PATHOGENIC .97799 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 76 ENSP00000395243.3:p.Ala722Val ENST00000454757.6:c.2165C>T 7:g.55181309C>T EGFR ENST00000275493.6 3633 3236 SW48 2302017 2167300 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166418 1166418 1078732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51815934 COSM28607 133206383 c.2468A>G p.E823G Substitution - Missense het 38 7:55191852-55191852 + - PATHOGENIC .96745 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 59 ENSP00000415559.1:p.Glu823Gly ENST00000455089.5:c.2468A>G 7:g.55191852A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00243T00243 2857340 2712640 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00190T00190 2857342 2712642 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732896 2732896 2591649 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 58 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2808102 2808102 2664786 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 31258848 surgery-fixed NS 60 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593028 1593028 1513954 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2785996 2785996 2643453 large_intestine colon right NS carcinoma neuroendocrine_carcinoma NS NS n COSV51787507 COSM13188 132557864 c.2146G>A p.D716N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 27586204 NS NS 72 ENSP00000395243.3:p.Asp716Asn ENST00000454757.6:c.2146G>A 7:g.55174818G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879550 1879550 1770052 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043129 1043129 959470 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 31 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879490 1879490 1769992 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879484 1879484 1769986 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2579398 2579398 2440735 NS NS NS NS malignant_melanoma NS NS NS n COSV51788796 COSM4680390 132569555 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000395243.3:p.Arg98Gln ENST00000454757.6:c.293G>A 7:g.55143357G>A EGFR ENST00000275493.6 3633 3236 1593028 1593028 1513954 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 015 2640419 2500721 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 27545006 fixed - NOS NS 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593001 1593001 1513927 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1093895 1093895 1008597 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18061305 pleural effusion NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450941 1450941 1375084 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 53 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862108 2862108 2717310 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51841095 COSM133588 132567838 c.2135A>G p.K712R Substitution - Missense 38 7:55174807-55174807 + - PATHOGENIC .9946 Reported in another cancer sample as somatic 31065835 surgery fresh/frozen NS ENSP00000395243.3:p.Lys712Arg ENST00000454757.6:c.2135A>G 7:g.55174807A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1500179 1500179 1423058 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983691 1983691 1869927 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891281 1891281 1780650 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895074 1895074 1783766 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098814 1098814 1013406 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 57 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429324 1429324 1338775 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453487 1453487 1377520 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1625786 1625786 1543010 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895127 1895127 1783819 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450864 1450864 1375007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875368 1875368 1765951 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875350 1875350 1765933 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1135416 1135416 1047980 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1160967 1160967 1073303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19002495 surgery-fixed primary 61 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453419 1453419 1377452 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899312 899312 816924 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 V104 1179745 1091707 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1648546 1648546 1563501 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983695 1983695 1869931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1500183 1500183 1423062 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 B127 1179748 1091710 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231326 1231326 1143116 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899303 899303 816915 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875369 1875369 1765952 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005360 1005360 922572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2147913 2147913 2017056 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 55 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1648543 1648543 1563498 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895082 1895082 1783774 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1054395 1054395 970466 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136888 1136888 1049452 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602816 1602816 1522152 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860426 1860426 1751367 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1000051 1000051 917274 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1884157 1884157 1774044 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592982 1592982 1513908 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1443061 1443061 1367346 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20837450 surgery - NOS primary 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1729758 1729758 1635729 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM255176 178385797 c.? p.A839T Substitution - Missense + - Reported in another cancer sample as somatic 22805266 NS NS ENSP00000275493.2:p.Ala839Thr EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895100 1895100 1783792 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899332 899332 816944 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860420 1860420 1751361 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1549819 1549819 1471924 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1734965 1734965 1640909 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1648541 1648541 1563496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891187 1891187 1780556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-B5-A0JZ-01 1783389 1687388 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51823220 COSM13179 132558313 c.1945C>T p.P649S Substitution - Missense hom 38 7:55173939-55173939 + - PATHOGENIC .97389 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 60 ENSP00000395243.3:p.Pro649Ser ENST00000454757.6:c.1945C>T 7:g.55173939C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1661392 1661392 1575007 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 22483783 surgery-fixed NS 61 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-196-tumor 2819081 2675380 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891317 1891317 1780686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891317 1891317 1780686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732918 2732918 2591671 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 39 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891312 1891312 1780681 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1469946 1469946 1393685 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 20522446 surgery-fixed NS 81 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2625627 2625627 2486039 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51767687 COSM6191352 99373482 c.1747G>A p.A583T Substitution - Missense het 38 7:55165304-55165304 + - PATHOGENIC .98656 Reported in another cancer sample as somatic 26488212 surgery-fixed NS ENSP00000275493.2:p.Ala583Thr ENST00000275493.6:c.1747G>A 7:g.55165304G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00383T00383 2857375 2712675 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 MG-175-tumor 2819068 2675367 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1005460 1005460 922672 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51777202 COSM20896 99421874 c.2500G>A p.V834M Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 16822827 fixed - NOS NS 24 ENSP00000275493.2:p.Val834Met ENST00000275493.6:c.2500G>A 7:g.55191749G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659760 2659760 2519918 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1213638 1213638 1125505 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 18978556 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345086 2345086 2209758 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2046606 2046606 1926900 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24195468 surgery - NOS recurrent 70 ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1881382 1881382 1771533 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1992084 1992084 1877401 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 84 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 411 898398 816010 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 2372543 2372543 2235336 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1451644 1451644 1375787 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51829458 COSM51497 132554096 c.2102_2103inv p.E701V Substitution - Missense 38 7:55174774-55174775 + - Reported in another cancer sample as somatic 20855820 surgery - NOS NS ENSP00000395243.3:p.Glu701Val ENST00000454757.6:c.2102_2103inv 7:g.55174774_55174775inv EGFR ENST00000275493.6 3633 3236 1459424 1459424 1383367 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 20489150 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2081828 2081828 1960250 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24481317 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NGS010 2875911 2730426 prostate NS NS NS carcinoma NS NS NS n COSV51792018 COSM4992972 132551365 c.2999C>T p.S1000F Substitution - Missense 38 7:55201754-55201754 + - PATHOGENIC .97067 Reported in another cancer sample as somatic 31580249 surgery-fixed NS ENSP00000395243.3:p.Ser1000Phe ENST00000454757.6:c.2999C>T 7:g.55201754C>T EGFR ENST00000275493.6 3633 3236 2011073 2011073 1893711 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2205992 2205992 2074225 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2026239 2026239 1908328 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51793933 COSM250050 132603810 c.2435G>A p.G812E Substitution - Missense het 38 7:55191819-55191819 + - PATHOGENIC .98882 Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000395243.3:p.Gly812Glu ENST00000454757.6:c.2435G>A 7:g.55191819G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891229 1891229 1780598 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1038990 1038990 955567 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1456559 1456559 1380534 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2878933 2878933 2733448 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 33115932 surgery-fixed NS 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1038991 1038991 955568 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2479713 2479713 2342459 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983741 1983741 1869977 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895135 1895135 1783827 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226868 2226868 2094603 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450927 1450927 1375070 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983737 1983737 1869973 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302282 1302282 1213333 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098854 1098854 1013446 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895163 1895163 1783855 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450938 1450938 1375081 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 76 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1627728 1627728 1544640 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1434025 1434025 1343440 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231320 1231320 1143110 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1751713 1751713 1656529 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895156 1895156 1783848 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1705345 1705345 1613329 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51769815 COSM249886 132571782 c.1961C>T p.P654L Substitution - Missense 38 7:55173955-55173955 + - PATHOGENIC .97389 Reported in another cancer sample as somatic 22722798 surgery - NOS recurrent 71 ENSP00000395243.3:p.Pro654Leu ENST00000454757.6:c.1961C>T 7:g.55173955C>T EGFR ENST00000275493.6 3633 3236 2840788 2840788 2696348 prostate NS NS NS carcinoma NS NS NS n COSV51824002 COSM6937752 99404206 c.2794C>T p.R932C Substitution - Missense 38 7:55198809-55198809 + - PATHOGENIC .91422 Reported in another cancer sample as somatic 31874108 surgery-fixed metastasis ENSP00000275493.2:p.Arg932Cys ENST00000275493.6:c.2794C>T 7:g.55198809C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2878946 2878946 2733461 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 33115932 surgery-fixed NS 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875342 1875342 1765925 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103805 1103805 1018057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778769 2778769 2636823 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 898242 898242 815854 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 15728811 surgery-fixed recurrent 73 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 IIIA 1179821 1091783 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19181917 surgery-fixed metastasis 27 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879567 1879567 1770069 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875362 1875362 1765945 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1541734 1541734 1464038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21469767 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231315 1231315 1143105 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103759 1103759 1018011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 76 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924523 924523 841296 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1881377 1881377 1771528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593015 1593015 1513941 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897838 897838 815460 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1451205 1451205 1375348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1789304 1789304 1692708 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LK-2 946071 862597 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891293 1891293 1780662 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009146 2009146 1891880 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1000059 1000059 917282 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1876995 1876995 1767557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1168012 1168012 1080254 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2064728 2064728 1944805 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM22423 178380012 c.? p.P733S Substitution - Missense + - Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Pro733Ser EGFR ENST00000275493.6 3633 3236 2680606 2680606 2539879 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 33 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2361977 2361977 2224920 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 25726043 NS NS 72 ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162653 1162653 1074985 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51796944 COSM28537 132554913 c.2425A>G p.T809A Substitution - Missense het 38 7:55191809-55191809 + - PATHOGENIC .9858 Reported in another cancer sample as somatic 19010870 surgery - NOS metastasis 69 ENSP00000395243.3:p.Thr809Ala ENST00000454757.6:c.2425A>G 7:g.55191809A>G EGFR ENST00000275493.6 3633 3236 2659760 2659760 2519918 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00383T00383 2857375 2712675 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-175-tumor 2819068 2675367 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2083100 2083100 1961521 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 24300726 surgery-fixed NS ENSP00000275493.2:p.Glu709Lys ABCC8 ENST00000302539.9 4749 59 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105879570 COSM10012873 102654792 c.2057T>C p.F686S Substitution - Missense 38 11:17427926-17427926 - - PATHOGENIC .98111 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000303960.4:p.Phe686Ser ENST00000302539.9:c.2057T>C 11:g.17427926A>G EGFR ENST00000275493.6 3633 3236 1231328 1231328 1143118 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897818 897818 815440 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042920 1042920 959261 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2840788 2840788 2696348 prostate NS NS NS carcinoma NS NS NS n COSV51785413 COSM1176673 99382805 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 31874108 surgery-fixed metastasis ENSP00000275493.2:p.Arg252His ENST00000275493.6:c.755G>A 7:g.55154018G>A EGFR ENST00000275493.6 3633 3236 1202559 1202559 1114445 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1098811 1098811 1013403 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18186961 surgery - NOS primary 61 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897827 897827 815449 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1876991 1876991 1767553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1197356 1197356 1109251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 984658 984658 900313 lung right_middle_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16619582 surgery-fixed primary 51 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895093 1895093 1783785 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891246 1891246 1780615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875338 1875338 1765921 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1077329 1077329 992583 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891186 1891186 1780555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1592997 1592997 1513923 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1593000 1593000 1513926 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1168008 1168008 1080250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BS-A0UV-01 1783478 1687477 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51773524 COSM1090858 133204241 c.418T>G p.L140V Substitution - Missense het 38 7:55143482-55143482 + - NEUTRAL .25717 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 55 ENSP00000415559.1:p.Leu140Val ENST00000455089.5:c.418T>G 7:g.55143482T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089596 1089596 1004543 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226904 2226904 2094639 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479953 1479953 1403613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895099 1895099 1783791 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924344 924344 841119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1625796 1625796 1543020 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1197350 1197350 1109245 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136882 1136882 1049446 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625556 2625556 2485968 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1242317 1242317 1154047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19671738 surgery - NOS metastasis 56 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 946822 946822 863345 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098858 1098858 1013450 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1135419 1135419 1047983 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-06-0237-01 1910211 1798502 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense hom 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 75 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 RPC-9 1083085 998250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17699786 cell-line NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2147905 2147905 2017048 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 45 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2402749 2402749 2265602 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 26267891 surgery-fixed primary 42 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778776 2778776 2636830 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1837422 1837422 1731621 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23242437 NS NS 68 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345090 2345090 2209762 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891275 1891275 1780644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1631943 1631943 1548813 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110469 1110469 1024347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1715001 1715001 1622580 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22710815 surgery-fixed primary 77 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LCSC_1 946053 862579 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891261 1891261 1780630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S003763 1027686 944662 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00237T00237 2857324 2712624 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1731088 1731088 1637059 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22815900 fine needle aspirate metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 H1975 2865440 2720570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 26340530 cell-line NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1498225 1498225 1421103 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21220471 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1435998 1435998 1345277 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 20439191 surgery fresh/frozen NS 49 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1585356 1585356 1506677 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22011666 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2147905 2147905 2017048 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 45 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042898 1042898 959239 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773049 COSM22943 133204348 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Pro803Leu ENST00000455089.5:c.2408C>T 7:g.55191792C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MTC34 2546185 2407665 thyroid NS NS NS carcinoma NS NS NS n COSV51773049 COSM22943 133204348 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 26294908 surgery - NOS NS ENSP00000415559.1:p.Pro803Leu ENST00000455089.5:c.2408C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 RPC-9 1083085 998250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17699786 cell-line NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2778776 2778776 2636830 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2402749 2402749 2265602 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 26267891 surgery-fixed primary 42 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 S001095 1027691 944667 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 1075800 1075800 991054 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 17575133 fixed - NOS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1135548 1135548 1048112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 18676761 NS NS 66 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1921886 1921886 1809204 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770634 1770634 1674874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515244 1515244 1437854 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469445 1469445 1393184 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777245 1777245 1681248 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264188 2264188 2131172 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290965 2290965 2157030 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862687 2862687 2717850 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31058075 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469401 1469401 1393140 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2032067 2032067 1913538 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24103528 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1007073 1007073 924281 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51772347 COSM17570 133206975 c.2087C>T p.P696L Substitution - Missense 38 7:55174759-55174759 + - PATHOGENIC .9905 Reported in another cancer sample as somatic 16410744 NS primary ENSP00000415559.1:p.Pro696Leu ENST00000455089.5:c.2087C>T 7:g.55174759C>T EGFR ENST00000275493.6 3633 3236 2345459 2345459 2210131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422944 2422944 2285866 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618062 1618062 1536858 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2152687 2152687 2021697 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24768118 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425769 2425769 2288690 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1532700 1532700 1455060 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20925915 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637222 1637222 1553270 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842973 1842973 1736221 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421227 2421227 2284149 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2089558 2089558 1967767 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24511003 surgery fresh/frozen NS 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637098 1637098 1553146 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 H1975 2865440 2720570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26340530 cell-line NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887372 1887372 1777044 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1706969 1706969 1614875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22722787 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096139 2096139 1974203 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469383 1469383 1393122 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000198 2000198 1885096 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226186 2226186 2093921 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1162987 1162987 1075310 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18992959 NS recurrent 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656984 1656984 1571639 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22338650 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081823 2081823 1960245 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481317 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264203 2264203 2131187 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637262 1637262 1553310 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1993800 1993800 1879056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23892415 surgery-fixed metastasis 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237688 1237688 1149435 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777421 1777421 1681424 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1530997 1530997 1453369 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469396 1469396 1393135 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1053139 1053139 969210 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17409961 surgery - NOS NS 81 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878849 2878849 2733364 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27368130 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881919 1881919 1772070 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 46 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000225 2000225 1885123 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549136 2549136 2410591 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842971 1842971 1736219 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2107337 2107337 1985200 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1223072 1223072 1134904 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 19473722 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770681 1770681 1674921 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680753 2680753 2540026 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264130 2264130 2131114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1732078 1732078 1638044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21622214 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1628372 1628372 1545278 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22263102 surgery - NOS primary 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637137 1637137 1553185 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345375 2345375 2210047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444743 1444743 1368986 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336424 1336424 1246809 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20430469 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264234 2264234 2131218 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874745 1874745 1765336 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522878 1522878 1445250 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921934 1921934 1809252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2141401 2141401 2010642 lung right_middle_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24636847 fine needle aspirate primary 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838658 1838658 1732759 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264159 2264159 2131143 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777263 1777263 1681266 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264280 2264280 2131264 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095996 2095996 1974060 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264171 2264171 2131155 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174301 1174301 1086320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921916 1921916 1809234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095989 2095989 1974053 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770658 1770658 1674898 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2225977 2225977 2093712 lung NS NS NS carcinoma NS NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24924582 fine needle aspirate NS ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2840788 2840788 2696348 prostate NS NS NS carcinoma NS NS NS n COSV51824002 COSM6937752 132572106 c.2659C>T p.R887C Substitution - Missense 38 7:55198809-55198809 + - PATHOGENIC .91422 Reported in another cancer sample as somatic 31874108 surgery-fixed metastasis ENSP00000395243.3:p.Arg887Cys ENST00000454757.6:c.2659C>T 7:g.55198809C>T EGFR ENST00000275493.6 3633 3236 5-GE026-T1 2869747 2724744 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51789362 COSM13184 99406147 c.2236G>A p.E746K Substitution - Missense 38 7:55174773-55174773 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 26950094 surgery - NOS NS 74 ENSP00000275493.2:p.Glu746Lys ENST00000275493.6:c.2236G>A 7:g.55174773G>A EGFR ENST00000275493.6 3633 3236 2905794 2905794 2760046 meninges NS NS NS meningioma NS NS NS n COSM34166 178380439 c.? p.R108K Substitution - Missense + - Reported in another cancer sample as somatic 31872418 surgery - NOS NS ENSP00000275493.2:p.Arg108Lys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302271 1302271 1213322 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 H1975 2776253 2634389 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29681454 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077337 1077337 992591 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1200919 1200919 1112809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668456 1668456 1581749 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453493 1453493 1377526 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875797 1875797 1766380 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897843 897843 815465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136875 1136875 1049439 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450877 1450877 1375020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 49 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899346 899346 816958 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009158 2009158 1891892 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1109733 1109733 1023643 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18372921 surgery-fixed primary 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990910 1990910 1876245 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895131 1895131 1783823 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891234 1891234 1780603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1047004 1047004 963235 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1188172 1188172 1100071 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19253367 surgery-fixed primary 77 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1090039 1090039 1004986 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17945377 surgery - NOS NS 32 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1047006 1047006 963237 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983693 1983693 1869929 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593017 1593017 1513943 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450873 1450873 1375016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302275 1302275 1213326 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1585353 1585353 1506674 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22011666 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891337 1891337 1780706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042858 1042858 959199 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879562 1879562 1770064 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1576785 1576785 1498226 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 60 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SW48 2302017 2167300 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005460 1005460 922672 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51777202 COSM20896 132585150 c.2365G>A p.V789M Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 16822827 fixed - NOS NS 24 ENSP00000395243.3:p.Val789Met ENST00000454757.6:c.2365G>A 7:g.55191749G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594565 1594565 1515533 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5330 915979 833378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773111 COSM13185 132548474 c.2117C>T p.T706I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000395243.3:p.Thr706Ile ENST00000454757.6:c.2117C>T 7:g.55174789C>T EGFR ENST00000275493.6 3633 3236 2131911 2131911 2005974 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM3718342 178387182 c.? p.S752F Substitution - Missense + - Reported in another cancer sample as somatic 24376723 fine needle aspirate primary ENSP00000275493.2:p.Ser752Phe EGFR ENST00000275493.6 3633 3236 MBC550 2807318 2664022 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51859563 COSM6910210 99376263 c.2509G>A p.D837N Substitution - Missense 38 7:55191758-55191758 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 31340200 surgery - NOS NS ENSP00000275493.2:p.Asp837Asn ENST00000275493.6:c.2509G>A 7:g.55191758G>A EGFR ENST00000275493.6 3633 3236 1074885 1074885 990139 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17505415 surgery fresh/frozen primary 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226903 2226903 2094638 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1110448 1110448 1024326 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875804 1875804 1766387 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226892 2226892 2094627 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1500182 1500182 1423061 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899323 899323 816935 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1162653 1162653 1074985 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19010870 surgery - NOS metastasis 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2479712 2479712 2342458 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1077336 1077336 992590 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2372589 2372589 2235382 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1573760 1573760 1495229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21982684 surgery fresh/frozen primary 76 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983712 1983712 1869948 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1668554 1668554 1581847 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302247 1302247 1213298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS 61 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891167 1891167 1780536 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042858 1042858 959199 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1110452 1110452 1024330 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891337 1891337 1780706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983703 1983703 1869939 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1990899 1990899 1876234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 911624 911624 829107 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2073269 2073269 1952508 upper_aerodigestive_tract sinonasal_and_nasal_cavity NS NS carcinoma adenocarcinoma intestinal NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24338245 surgery-fixed NS 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NGS010 2875911 2730426 prostate NS NS NS carcinoma NS NS NS n COSV51792018 COSM4992972 133206283 c.2999C>T p.S1000F Substitution - Missense 38 7:55201754-55201754 + - PATHOGENIC .97067 Reported in another cancer sample as somatic 31580249 surgery-fixed NS ENSP00000415559.1:p.Ser1000Phe ENST00000455089.5:c.2999C>T 7:g.55201754C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899355 899355 816967 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914804 914804 832253 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15738541 surgery fresh/frozen recurrent ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042861 1042861 959202 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879526 1879526 1770028 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1576785 1576785 1498226 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 60 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1042858 1042858 959199 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1891337 1891337 1780706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879562 1879562 1770064 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T155 1861137 1752078 endometrium NS NS NS carcinoma serous_carcinoma NS NS y COSV51785413 COSM1176673 133211383 c.620G>A p.R207H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 23104009 surgery fresh/frozen primary ENSP00000415559.1:p.Arg207His ENST00000455089.5:c.620G>A 7:g.55154018G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2841814 2841814 2697363 soft_tissue fibrous_tissue_and_uncertain_origin abdomen NS desmoid_tumour-fibromatosis NS NS NS n COSV99290440 COSM7410173 133243622 c.3038G>A p.C1013Y Substitution - Missense 38 7:55202527-55202527 + - NEUTRAL .29295 Reported in another cancer sample as somatic 32099073 surgery-fixed NS 27 ENSP00000415559.1:p.Cys1013Tyr ENST00000455089.5:c.3038G>A 7:g.55202527G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372543 2372543 2235336 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1468062 1468062 1391908 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 57 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1246728 1246728 1158407 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2664371 2664371 2524428 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 45 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1498636 1498636 1421514 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21315472 surgery - NOS metastasis 54 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027754 2027754 1909657 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081909 2081909 1960331 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2345853 2345853 2210525 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264425 2264425 2131409 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481225 1481225 1404854 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525689 2525689 2387878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 bronchoalveolar lavage fluid recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1246726 1246726 1158405 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2241830 2241830 2109361 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25228365 NS primary ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453420 1453420 1377453 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875366 1875366 1765949 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 924342 924342 841117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162200 1162200 1074532 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1160966 1160966 1073302 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19002495 surgery-fixed primary 50 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302284 1302284 1213335 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226895 2226895 2094630 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1052728 1052728 968799 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17368623 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-02-0089-01 1910158 1798449 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense hom 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 54 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 TCGA-02-0089-01 1910158 1798449 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense hom 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 54 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891164 1891164 1780533 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983705 1983705 1869941 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450844 1450844 1374987 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 55 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136892 1136892 1049456 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-0829-01 2178136 2046434 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772147 COSM375343 133220930 c.1799C>G p.S600C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Confirmed somatic variant 329 NS NS 75 ENSP00000415559.1:p.Ser600Cys ENST00000455089.5:c.1799C>G 7:g.55172997C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226878 2226878 2094613 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1135421 1135421 1047985 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897806 897806 815428 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1074889 1074889 990143 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17505415 surgery fresh/frozen primary 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2027349 2027349 1909417 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897283 897283 814906 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15118073 surgery fresh/frozen primary 32 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136878 1136878 1049442 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593020 1593020 1513946 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372591 2372591 2235384 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983744 1983744 1869980 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089139 1089139 1004093 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1627727 1627727 1544639 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899326 899326 816938 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990915 1990915 1876250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1541731 1541731 1464035 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21469767 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899331 899331 816943 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2878948 2878948 2733463 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 33115932 surgery-fixed NS 65 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891223 1891223 1780592 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1295829 1295829 1206901 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19640859 fine needle aspirate primary 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602808 1602808 1522144 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1434028 1434028 1343443 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983718 1983718 1869954 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1038994 1038994 955571 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2161696 2161696 2030303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24813888 pleural effusion NS 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1549821 1549821 1471926 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897803 897803 815425 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1602802 1602802 1522138 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1024776 1024776 941753 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 pleural effusion recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1992086 1992086 1877403 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 50 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5313 915983 833382 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51860329 COSM13190 133219847 c.2240T>C p.L747P Substitution - Missense 38 7:55181384-55181384 + - PATHOGENIC .95089 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000415559.1:p.Leu747Pro ENST00000455089.5:c.2240T>C 7:g.55181384T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042898 1042898 959239 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773049 COSM22943 132549396 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Pro803Leu ENST00000454757.6:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MTC34 2546185 2407665 thyroid NS NS NS carcinoma NS NS NS n COSV51773049 COSM22943 132549396 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 26294908 surgery - NOS NS ENSP00000395243.3:p.Pro803Leu ENST00000454757.6:c.2408C>T 7:g.55191792C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879577 1879577 1770079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891329 1891329 1780698 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2432376 2432376 2295279 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 26473643 surgery fresh/frozen metastasis 53 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891321 1891321 1780690 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891326 1891326 1780695 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879579 1879579 1770081 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042897 1042897 959238 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879573 1879573 1770075 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S001095 1027691 944667 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1235132 1235132 1146918 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 54 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879576 1879576 1770078 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879554 1879554 1770056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879505 1879505 1770007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1894921 1894921 1783613 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-RR-A6KC-01 2339255 2204238 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 132553689 c.619C>T p.R207C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 NS primary 55 ENSP00000395243.3:p.Arg207Cys ENST00000454757.6:c.619C>T 7:g.55154017C>T EGFR ENST00000275493.6 3633 3236 122 1881682 1771833 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23391413 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1881382 1881382 1771533 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1746449 1746449 1651425 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 22895145 NS NS 68 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1770506 1770506 1674746 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965858 1965858 1852351 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046612 2046612 1926906 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264088 2264088 2131072 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444800 1444800 1369043 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664342 2664342 2524414 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964341 1964341 1850876 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2437219 2437219 2300069 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26469914 surgery - NOS primary 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965826 1965826 1852319 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2007099 2007099 1889980 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23790173 surgery-fixed NS 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1678331 1678331 1590987 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22579408 NS NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875684 1875684 1766267 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475411 1475411 1399110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618700 1618700 1537452 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1802285 1802285 1704004 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23136191 surgery-fixed NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240547 2240547 2108078 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25227801 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1235145 1235145 1146931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19589612 surgery - NOS recurrent 85 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336428 1336428 1246813 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20430469 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2032068 2032068 1913539 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24103528 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118443 2118443 1992678 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474438 2474438 2337207 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2552468 2552468 2413909 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27553514 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1498636 1498636 1421514 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21315472 surgery - NOS metastasis 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 HCC4011R 1890458 1779879 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22773810 cell-line NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096081 2096081 1974145 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459500 1459500 1383443 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081909 2081909 1960331 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2260326 2260326 2127311 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25263855 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1424052 1424052 1334080 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20595147 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966252 1966252 1852745 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23800712 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551542 1551542 1473647 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1062894 1062894 978939 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17387741 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656979 1656979 1571634 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22338650 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1434750 1434750 1344108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20813423 surgery - NOS primary 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637237 1637237 1553285 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214542 2214542 2082666 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777212 1777212 1681215 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422793 2422793 2285715 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083817 1083817 998982 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469387 1469387 1393126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1993866 1993866 1879122 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23892415 surgery-fixed metastasis 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542143 1542143 1464446 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096065 2096065 1974129 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425728 2425728 2288649 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329250 1329250 1239735 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960180 1960180 1846820 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2437329 2437329 2300179 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23211219 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965887 1965887 1852380 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1154577 1154577 1066913 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18946755 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2788199 2788199 2645581 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 30922578 surgery fresh/frozen primary 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921903 1921903 1809221 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515258 1515258 1437868 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1467316 1467316 1391162 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20940188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469345 1469345 1393084 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264239 2264239 2131223 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264182 2264182 2131166 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535053 1535053 1457388 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345383 2345383 2210055 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777369 1777369 1681372 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MBC550 2807318 2664022 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51859563 COSM6910210 132549516 c.2374G>A p.D792N Substitution - Missense 38 7:55191758-55191758 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 31340200 surgery - NOS NS ENSP00000395243.3:p.Asp792Asn ENST00000454757.6:c.2374G>A 7:g.55191758G>A EGFR ENST00000275493.6 3633 3236 1637074 1637074 1553122 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637194 1637194 1553242 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770704 1770704 1674944 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1075009 1075009 990263 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205962 2205962 2074195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842988 1842988 1736236 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345482 2345482 2210154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163058 2163058 2031642 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240552 2240552 2108083 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25227801 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1856346 1856346 1748899 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881928 1881928 1772079 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770685 1770685 1674925 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637120 1637120 1553168 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1695740 1695740 1603952 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22673630 fine needle aspirate primary 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025391 2025391 1907480 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1635369 1635369 1551874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22335887 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046024 2046024 1926319 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1196952 1196952 1108847 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875689 1875689 1766272 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2241830 2241830 2109361 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25228365 NS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-078-tumor 2819014 2675313 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-057-tumor 2818998 2675297 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 TCGA-86-8075-01 1914090 1802372 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1038996 1038996 955573 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1860421 1860421 1751362 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453414 1453414 1377447 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891255 1891255 1780624 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1435997 1435997 1345276 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen primary 49 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1517069 1517069 1439663 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983762 1983762 1869998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891184 1891184 1780553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1110451 1110451 1024329 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1434024 1434024 1343439 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1429295 1429295 1338746 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2064713 2064713 1944790 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891225 1891225 1780594 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891237 1891237 1780606 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1789318 1789318 1692722 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899334 899334 816946 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2078357 2078357 1957076 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24314215 pleural effusion NS 88 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1631952 1631952 1548822 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2817999 2817999 2674298 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31422893 pleural effusion metastasis 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1166432 1166432 1078746 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51815927 COSM24971 99392587 c.2513T>C p.L838P Substitution - Missense hom 38 7:55191762-55191762 + - PATHOGENIC .97813 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 59 ENSP00000275493.2:p.Leu838Pro ENST00000275493.6:c.2513T>C 7:g.55191762T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1500584 1500584 1423463 stomach NS NS NS carcinoma mucinous_adenocarcinoma NS NS n COSV51778659 COSM14070 133202857 c.2453G>A p.G818D Substitution - Missense het 38 7:55191837-55191837 + - PATHOGENIC .92688 Reported in another cancer sample as somatic 21436633 surgery - NOS NS 76 ENSP00000415559.1:p.Gly818Asp ENST00000455089.5:c.2453G>A 7:g.55191837G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T155 1861137 1752078 endometrium NS NS NS carcinoma serous_carcinoma NS NS y COSV51785413 COSM1176673 132555528 c.620G>A p.R207H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 23104009 surgery fresh/frozen primary ENSP00000395243.3:p.Arg207His ENST00000454757.6:c.620G>A 7:g.55154018G>A EGFR ENST00000275493.6 3633 3236 1047954 1047954 964182 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM23613 178378830 c.? p.G719D Substitution - Missense + - Reported in another cancer sample as somatic 17337084 surgery-fixed NS ENSP00000275493.2:p.Gly719Asp EGFR ENST00000275493.6 3633 3236 897829 897829 815451 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2064711 2064711 1944788 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895119 1895119 1783811 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1672196 1672196 1585384 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21917678 fine needle aspirate NS 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1738960 1738960 1644791 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875351 1875351 1765934 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226919 2226919 2094654 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891260 1891260 1780629 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1593011 1593011 1513937 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226874 2226874 2094609 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891301 1891301 1780670 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1894921 1894921 1783613 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1468622 1468622 1392373 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM53179 178383575 c.? p.V834L Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Val834Leu EGFR ENST00000275493.6 3633 3236 1468622 1468622 1392373 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2733227 2733227 2591980 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 133203297 c.1652C>T p.P551L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 61 ENSP00000415559.1:p.Pro551Leu ENST00000455089.5:c.1652C>T 7:g.55165344C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166418 1166418 1078732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51843707 COSM28601 133206370 c.2000T>C p.F667S Substitution - Missense het 38 7:55173994-55173994 + - PATHOGENIC .9621 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 59 ENSP00000415559.1:p.Phe667Ser ENST00000455089.5:c.2000T>C 7:g.55173994T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 HN_62995 1560583 1482033 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825459 COSM122789 132558008 c.1288A>G p.I430V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Reported in another cancer sample as somatic 21798893 surgery fresh/frozen primary ENSP00000395243.3:p.Ile430Val ENST00000454757.6:c.1288A>G 7:g.55160263A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1310473 1310473 1221418 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1981023 1981023 1867259 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 122 1881682 1771833 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 23391413 surgery-fixed NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1575150 1575150 1496591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895128 1895128 1783820 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895084 1895084 1783776 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594601 1594601 1515569 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891219 1891219 1780588 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990912 1990912 1876247 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1549818 1549818 1471923 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592989 1592989 1513915 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110465 1110465 1024343 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1295380 1295380 1206459 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19881244 surgery-fixed NS 90 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Sq-1 946075 862601 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1434017 1434017 1343432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1090038 1090038 1004985 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17945377 surgery - NOS primary 32 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1610921 1610921 1530149 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22157931 surgery-fixed primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625558 2625558 2485970 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983765 1983765 1870001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098866 1098866 1013458 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239178 2239178 2106710 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 53 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879526 1879526 1770028 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1672416 1672416 1585470 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21729655 fine needle aspirate primary 45 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2862242 2862242 2717432 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25969368 surgery-fixed primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1135548 1135548 1048112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 18676761 NS NS 66 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2132036 2132036 2006099 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24429877 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2841857 2841857 2697406 soft_tissue fibrous_tissue_and_uncertain_origin trunk NS desmoid_tumour-fibromatosis NS NS NS n COSV51777833 COSM4680394 133212226 c.1445G>A p.R482Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Reported in another cancer sample as somatic 32099073 surgery-fixed NS 27 ENSP00000415559.1:p.Arg482Gln ENST00000455089.5:c.1445G>A 7:g.55161580G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098814 1098814 1013406 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767386 COSM18423 133220856 c.2365G>T p.V789L Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .9903 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 57 ENSP00000415559.1:p.Val789Leu ENST00000455089.5:c.2365G>T 7:g.55191749G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 H1975 2776253 2634389 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29681454 NS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980069 1980069 1866312 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 73 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879510 1879510 1770012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 5330 915979 833378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773111 COSM13185 99375118 c.2252C>T p.T751I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000275493.2:p.Thr751Ile ENST00000275493.6:c.2252C>T 7:g.55174789C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226908 2226908 2094643 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239187 2239187 2106719 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 48 ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 907082 907082 824594 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-NYU1101 1765169 1669489 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 72 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891301 1891301 1780670 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S001108 1027693 944669 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 17177598 cell-line NS ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879549 1879549 1770051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980067 1980067 1866310 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 68 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1435991 1435991 1345270 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen primary 85 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166443 1166443 1078757 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983706 1983706 1869942 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089136 1089136 1004090 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924334 924334 841109 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089600 1089600 1004547 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990908 1990908 1876243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471794 1471794 1395532 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1694963 1694963 1603183 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1435995 1435995 1345274 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery-fixed primary 59 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602815 1602815 1522151 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1310475 1310475 1221420 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009164 2009164 1891898 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983786 1983786 1870022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226897 2226897 2094632 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103630 1103630 1017882 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862729 2862729 2717892 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891250 1891250 1780619 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593004 1593004 1513930 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990907 1990907 1876242 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1530670 1530670 1453042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21227397 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899338 899338 816950 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668553 1668553 1581846 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920160 920160 837240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 47 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875805 1875805 1766388 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1541735 1541735 1464039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21469767 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2471442 2471442 2334228 skin NS NS NS malignant_melanoma NS NS NS n COSV51836136 COSM5574310 132566153 c.2764G>A p.E922K Substitution - Missense 38 7:55200366-55200366 + - PATHOGENIC .99379 Reported in another cancer sample as somatic 25452114 surgery fresh/frozen metastasis 55 ENSP00000395243.3:p.Glu922Lys ENST00000454757.6:c.2764G>A 7:g.55200366G>A EGFR ENST00000275493.6 3633 3236 1434025 1434025 1343440 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1038990 1038990 955567 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1231320 1231320 1143110 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226868 2226868 2094603 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895135 1895135 1783827 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2479713 2479713 2342459 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895163 1895163 1783855 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1751713 1751713 1656529 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1038991 1038991 955568 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302282 1302282 1213333 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983737 1983737 1869973 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2878933 2878933 2733448 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 33115932 surgery-fixed NS 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1098854 1098854 1013446 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450938 1450938 1375081 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 76 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895156 1895156 1783848 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001303-T01-IM3 2717027 2575848 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001303-T01-IM3 2717027 2575848 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51807743 COSM133179 133222581 c.1930G>A p.V644M Substitution - Missense het 38 7:55173924-55173924 + - PATHOGENIC .9843 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Val644Met ENST00000455089.5:c.1930G>A 7:g.55173924G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004119-T01-IM5 2720520 2579341 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 132553689 c.619C>T p.R207C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg207Cys ENST00000454757.6:c.619C>T 7:g.55154017C>T EGFR ENST00000275493.6 3633 3236 1983741 1983741 1869977 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450927 1450927 1375070 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1456559 1456559 1380534 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20459863 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891229 1891229 1780598 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1627728 1627728 1544640 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 3595 915982 833381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51775222 COSM13189 133214176 c.2216C>T p.S739F Substitution - Missense 38 7:55181360-55181360 + - PATHOGENIC .94833 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000415559.1:p.Ser739Phe ENST00000455089.5:c.2216C>T 7:g.55181360C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862785 2862785 2717948 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592970 1592970 1513896 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773111 COSM13185 132548474 c.2117C>T p.T706I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Thr706Ile ENST00000454757.6:c.2117C>T 7:g.55174789C>T EGFR ENST00000275493.6 3633 3236 1884157 1884157 1774044 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1443061 1443061 1367346 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20837450 surgery - NOS primary 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004718-T01-IM5 2721121 2579942 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 104 2786511 2643934 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51780877 COSM26717 133203719 c.2444A>T p.K815I Substitution - Missense 38 7:55191828-55191828 + - PATHOGENIC .95726 Reported in another cancer sample as somatic 30115035 surgery-fixed NS ENSP00000415559.1:p.Lys815Ile ENST00000455089.5:c.2444A>T 7:g.55191828A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 pros_01_dx 2688203 2547185 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 544 NS primary 41 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 912470 912470 829962 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 15625347 NS NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1592982 1592982 1513908 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891187 1891187 1780556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899332 899332 816944 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983695 1983695 1869931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895082 1895082 1783774 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1860420 1860420 1751361 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899303 899303 816915 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1231326 1231326 1143116 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 V104 1179745 1091707 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602816 1602816 1522152 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1000051 1000051 917274 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1648546 1648546 1563501 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1734965 1734965 1640909 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22848293 surgery fresh/frozen NS 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897826 897826 815448 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1625795 1625795 1543019 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897832 897832 815454 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895157 1895157 1783849 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064715 2064715 1944792 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226894 2226894 2094629 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1610922 1610922 1530150 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22157931 pleural effusion NS 61 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593005 1593005 1513931 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450846 1450846 1374989 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 44 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860416 1860416 1751357 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372590 2372590 2235383 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862720 2862720 2717883 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1320682 1320682 1231569 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20155428 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136870 1136870 1049434 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1648541 1648541 1563496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2147913 2147913 2017056 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 55 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1054395 1054395 970466 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17409930 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875369 1875369 1765952 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 B127 1179748 1091710 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1860426 1860426 1751367 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1500183 1500183 1423062 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1549819 1549819 1471924 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1648543 1648543 1563498 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1005360 1005360 922572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136888 1136888 1049452 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895100 1895100 1783792 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899318 899318 816930 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1162206 1162206 1074538 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766880 COSM28516 133219865 c.2269G>T p.V757F Substitution - Missense 38 7:55181413-55181413 + - PATHOGENIC .89385 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000415559.1:p.Val757Phe ENST00000455089.5:c.2269G>T 7:g.55181413G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166432 1166432 1078746 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51815927 COSM24971 132563635 c.2378T>C p.L793P Substitution - Missense hom 38 7:55191762-55191762 + - PATHOGENIC .97813 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 59 ENSP00000395243.3:p.Leu793Pro ENST00000454757.6:c.2378T>C 7:g.55191762T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00443T00443 2857349 2712649 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-050-tumor 2818996 2675295 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1891326 1891326 1780695 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1891321 1891321 1780690 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879573 1879573 1770075 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879579 1879579 1770081 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1042897 1042897 959238 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-070-tumor 2819006 2675305 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00173T00173 2857372 2712672 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067076 1067076 983056 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226873 2226873 2094608 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110461 1110461 1024339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899335 899335 816947 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983751 1983751 1869987 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1083996 1083996 999161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17785547 surgery fresh/frozen primary 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005361 1005361 922573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875800 1875800 1766383 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1468059 1468059 1391905 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 57 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618729 1618729 1537481 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 58 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1312890 1312890 1223799 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19884861 blood-bone marrow NS 54 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2228269 2228269 2096002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2664351 2664351 2524418 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 48 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027738 2027738 1909641 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239182 2239182 2106714 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 fine needle aspirate NS 48 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2733662 2733662 2592415 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29721166 cerebrospinal fluid metastasis 71 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1202557 1202557 1114443 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2064707 2064707 1944784 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302277 1302277 1213328 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-50-5944-01 1780167 1684166 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2479711 2479711 2342457 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983734 1983734 1869970 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1627722 1627722 1544634 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897841 897841 815463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226881 2226881 2094616 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1526688 1526688 1449056 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51796850 COSM24846 132580433 c.2356C>T p.R786C Substitution - Missense het 38 7:55191740-55191740 + - PATHOGENIC .9406 Reported in another cancer sample as somatic 21573507 surgery-fixed NS ENSP00000395243.3:p.Arg786Cys ENST00000454757.6:c.2356C>T 7:g.55191740C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-02-0016-01 1910129 1798420 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 50 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 TCGA-RR-A6KC-01 2339255 2204238 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 99380629 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 NS primary 55 ENSP00000275493.2:p.Arg252Cys ENST00000275493.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2539014 2539014 2400609 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 133219858 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Reported in another cancer sample as somatic 26749488 NS recurrent 57 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2255G>C 7:g.55181399G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895066 1895066 1783758 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2734338 2734338 2593065 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 29731638 surgery - NOS NS 52 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 56 2760164 2618697 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51796850 COSM24846 133241496 c.2356C>T p.R786C Substitution - Missense 38 7:55191740-55191740 + - PATHOGENIC .9406 Reported in another cancer sample as somatic 29876005 surgery-fixed NS ENSP00000415559.1:p.Arg786Cys ENST00000455089.5:c.2356C>T 7:g.55191740C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 3695 915981 833380 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51787507 COSM13188 132557864 c.2146G>A p.D716N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000395243.3:p.Asp716Asn ENST00000454757.6:c.2146G>A 7:g.55174818G>A EGFR ENST00000275493.6 3633 3236 2136616 2136616 2006167 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS 63 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2264377 2264377 2131361 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2083099 2083099 1961520 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24300726 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2629466 2629466 2489850 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51797168 COSM87247 132576297 c.2452G>A p.G818S Substitution - Missense 38 7:55191836-55191836 + - PATHOGENIC .94673 Reported in another cancer sample as somatic 26317919 surgery-fixed NS 72 ENSP00000395243.3:p.Gly818Ser ENST00000454757.6:c.2452G>A 7:g.55191836G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-02-0046-01 1910140 1798431 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 61 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1231316 1231316 1143106 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043860 1043860 960201 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239187 2239187 2106719 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 48 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592987 1592987 1513913 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875377 1875377 1765960 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1991298 1991298 1876633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD_E01419 1765148 1669468 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 51 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891243 1891243 1780612 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1075005 1075005 990259 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891238 1891238 1780607 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450930 1450930 1375073 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 51 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239177 2239177 2106709 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 56 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879505 1879505 1770007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879576 1879576 1770078 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1235132 1235132 1146918 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 54 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879554 1879554 1770056 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1031900 1031900 948691 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17085664 NS recurrent ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 IR3T 897723 815346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15118125 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1931643 1931643 1818933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891242 1891242 1780611 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136868 1136868 1049432 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897830 897830 815452 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103805 1103805 1018057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1434021 1434021 1343436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009162 2009162 1891896 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194737 1194737 1106632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 983147 983147 898865 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444738 1444738 1368981 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228806 2228806 2096518 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24956168 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264226 2264226 2131210 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173406 1173406 1085490 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173411 1173411 1085495 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591005 1591005 1512121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2115441 2115441 1989685 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23915069 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096176 2096176 1974240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120934 1120934 1034090 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444801 1444801 1369044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264293 2264293 2131277 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637707 2637707 2498080 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638743 1638743 1554742 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1223077 1223077 1134909 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 19473722 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493363 1493363 1416353 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096013 2096013 1974077 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965891 1965891 1852384 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345373 2345373 2210045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1498638 1498638 1421516 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21315472 surgery - NOS metastasis 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264105 2264105 2131089 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346487 2346487 2211150 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618729 1618729 1537481 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777265 1777265 1681268 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1312890 1312890 1223799 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19884861 blood-bone marrow NS 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591060 1591060 1512176 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1202164 1202164 1114050 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19371962 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345481 2345481 2210153 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777357 1777357 1681360 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345387 2345387 2210059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2809829 2809829 2666497 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31315676 surgery - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 28 1596838 1517551 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20093389 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1576816 1576816 1498257 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21921847 surgery - NOS primary 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777250 1777250 1681253 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479100 1479100 1402793 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047763 2047763 1928035 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240661 2240661 2108192 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011154 2011154 1893792 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459515 1459515 1383458 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1036698 1036698 953455 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17106442 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345561 2345561 2210233 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731384 1731384 1637350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22457323 NS NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777351 1777351 1681354 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218535 2218535 2086546 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960166 1960166 1846806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838735 1838735 1732836 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774680 1774680 1678904 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS metastasis 85 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430049 1430049 1339467 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542144 1542144 1464447 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542156 1542156 1464459 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770630 1770630 1674870 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421212 2421212 2284134 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1154305 1154305 1066641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18957054 surgery-fixed NS 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1732076 1732076 1638042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21622214 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1235623 1235623 1147386 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19584155 surgery-fixed metastasis 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096076 2096076 1974140 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983156 983156 898874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542346 1542346 1464649 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083068 1083068 998233 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17685931 surgery-fixed NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118445 2118445 1992680 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770671 1770671 1674911 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842956 1842956 1736204 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203076 2203076 2071334 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2290953 2290953 2157018 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25264883 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421224 2421224 2284146 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345544 2345544 2210216 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965208 1965208 1851703 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23803047 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 999903 999903 917126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16827805 pleural effusion NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230462 1230462 1142276 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046048 2046048 1926343 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1112953 1112953 1026464 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448997 surgery-fixed NS 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264240 2264240 2131224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885187 1885187 1775074 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2151454 2151454 2020488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24742923 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2131911 2131911 2005974 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM23617 178385408 c.? p.T785I Substitution - Missense + - Reported in another cancer sample as somatic 24376723 fine needle aspirate primary ENSP00000275493.2:p.Thr785Ile EGFR ENST00000275493.6 3633 3236 MG-057-tumor 2818998 2675297 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 MG-078-tumor 2819014 2675313 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S001067 1027687 944663 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 132551880 c.652A>C p.T218P Substitution - Missense hom 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Thr218Pro ENST00000454757.6:c.652A>C 7:g.55154050A>C EGFR ENST00000275493.6 3633 3236 912470 912470 829962 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 15625347 NS NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226767 2226767 2094502 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879580 1879580 1770082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51796944 COSM28537 132554913 c.2425A>G p.T809A Substitution - Missense 38 7:55191809-55191809 + - PATHOGENIC .9858 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr809Ala ENST00000454757.6:c.2425A>G 7:g.55191809A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004491-T01-IM5 2720890 2579711 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28481359 surgery - NOS primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668469 1668469 1581762 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780766 COSM219795 132546924 c.2456C>T p.A819V Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .93098 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Ala819Val ENST00000454757.6:c.2456C>T 7:g.55191840C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A103-T-S25 2757418 2616003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BS-A0UV-01 1783478 1687477 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51773524 COSM1090858 132549299 c.418T>G p.L140V Substitution - Missense het 38 7:55143482-55143482 + - NEUTRAL .25717 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 55 ENSP00000395243.3:p.Leu140Val ENST00000454757.6:c.418T>G 7:g.55143482T>G EGFR ENST00000275493.6 3633 3236 2226767 2226767 2094502 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895066 1895066 1783758 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2027352 2027352 1909420 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 58 ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162206 1162206 1074538 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766880 COSM28516 132563580 c.2269G>T p.V757F Substitution - Missense 38 7:55181413-55181413 + - PATHOGENIC .89385 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000395243.3:p.Val757Phe ENST00000454757.6:c.2269G>T 7:g.55181413G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226908 2226908 2094643 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1029330 1029330 946201 upper_aerodigestive_tract pharynx oropharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51789362 COSM13184 132574086 c.2101G>A p.E701K Substitution - Missense 38 7:55174773-55174773 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 17121883 surgery-fixed NS ENSP00000395243.3:p.Glu701Lys ENST00000454757.6:c.2101G>A 7:g.55174773G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BC1-3 2824185 2680012 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51787208 COSM327142 132549881 c.3217G>A p.A1073T Substitution - Missense 38 7:55205336-55205336 + - NEUTRAL .10522 Reported in another cancer sample as somatic 31867841 circulating tumour recurrent 54 ENSP00000395243.3:p.Ala1073Thr ENST00000454757.6:c.3217G>A 7:g.55205336G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1576801 1576801 1498242 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 62 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879558 1879558 1770060 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891324 1891324 1780693 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004496-T01-IM5 2720895 2579716 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1576804 1576804 1498245 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 surgery - NOS primary 64 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 899355 899355 816967 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862785 2862785 2717948 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372586 2372586 2235379 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659800 2659800 2519958 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042908 1042908 959249 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875352 1875352 1765935 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895166 1895166 1783858 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103629 1103629 1017881 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 53 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1074879 1074879 990133 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17505415 surgery fresh/frozen primary 71 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1981019 1981019 1867255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302268 1302268 1213319 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 907089 907089 824601 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891181 1891181 1780550 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009152 2009152 1891886 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625560 2625560 2485972 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 51 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895143 1895143 1783835 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895130 1895130 1783822 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1627725 1627725 1544637 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862708 2862708 2717871 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2277204 2277204 2143736 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25328676 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862719 2862719 2717882 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592998 1592998 1513924 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2840305 2840305 2695865 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31632838 surgery - NOS NS 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302285 1302285 1213336 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895105 1895105 1783797 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EXTERN_MELA_20140526_088 2839362 2695128 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 132553183 c.1033C>A p.Q345K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000395243.3:p.Gln345Lys ENST00000454757.6:c.1033C>A 7:g.55156793C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668436 1668436 1581729 lung bronchus NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22526156 surgery-fixed primary 18 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194731 1194731 1106626 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1007073 1007073 924281 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51772347 COSM17570 132552045 c.2087C>T p.P696L Substitution - Missense 38 7:55174759-55174759 + - PATHOGENIC .9905 Reported in another cancer sample as somatic 16410744 NS primary ENSP00000395243.3:p.Pro696Leu ENST00000454757.6:c.2087C>T 7:g.55174759C>T EGFR ENST00000275493.6 3633 3236 3695 915981 833380 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51787507 COSM13188 99385457 c.2281G>A p.D761N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000275493.2:p.Asp761Asn ENST00000275493.6:c.2281G>A 7:g.55174818G>A EGFR ENST00000275493.6 3633 3236 2264373 2264373 2131357 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1120915 1120915 1034071 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1479090 1479090 1402783 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2046185 2046185 1926480 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2046605 2046605 1926899 lung NS NS NS carcinoma mixed_small_cell_carcinoma-adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24195468 surgery - NOS primary 70 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2131900 2131900 2005964 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419415 NS NS 42 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2096222 2096222 1974286 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1618634 1618634 1537386 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 81 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525699 2525699 2387888 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618767 1618767 1537519 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22215752 surgery-fixed NS 50 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469811 1469811 1393550 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469862 1469862 1393601 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2153081 2153081 2022091 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2427392 2427392 2290313 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26424310 autopsy - NOS metastasis 63 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2580500 2580500 2441837 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27895763 circulating tumour NS 45 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746660 1746660 1651636 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 51 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1967522 1967522 1854014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23807543 fixed - NOS metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1965279 1965279 1851774 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23803047 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-A52771 2905636 2759892 NS NS NS NS malignant_melanoma NS NS NS n COSV51792018 COSM4992972 133206283 c.2999C>T p.S1000F Substitution - Missense 38 7:55201754-55201754 + - PATHOGENIC .97067 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Ser1000Phe ENST00000455089.5:c.2999C>T 7:g.55201754C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-17-A52771 2905636 2759892 NS NS NS NS malignant_melanoma NS NS NS n COSV51792018 COSM4992972 132551365 c.2999C>T p.S1000F Substitution - Missense 38 7:55201754-55201754 + - PATHOGENIC .97067 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Ser1000Phe ENST00000454757.6:c.2999C>T 7:g.55201754C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982887 982887 898606 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 3615 915978 833377 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51789362 COSM13184 133232364 c.2101G>A p.E701K Substitution - Missense 38 7:55174773-55174773 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000415559.1:p.Glu701Lys ENST00000455089.5:c.2101G>A 7:g.55174773G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 24 2570197 2431494 skin chest_wall NS NS adnexal_tumour sebaceous_carcinoma NS NS n COSV51794784 COSM13182 132548944 c.2068G>A p.G690S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 79 ENSP00000395243.3:p.Gly690Ser ENST00000454757.6:c.2068G>A 7:g.55174740G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1235125 1235125 1146911 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 58 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2539013 2539013 2400608 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 26749488 NS metastasis 57 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1980071 1980071 1866314 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 61 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1590011 1590011 1511165 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21995391 surgery-fixed recurrent 55 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2555799 2555799 2417236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 26599269 surgery - NOS NS 58 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1246741 1246741 1158420 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2345122 2345122 2209794 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1542341 1542341 1464644 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881907 1881907 1772058 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705468 1705468 1613374 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493359 1493359 1416349 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118447 2118447 1992682 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246719 1246719 1158398 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469404 1469404 1393143 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425738 2425738 2288659 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2007093 2007093 1889974 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23790173 surgery-fixed NS 67 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-08-0380-01 1910239 1798530 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779162 COSM21689 132548259 c.1652C>T p.P551L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 74 ENSP00000395243.3:p.Pro551Leu ENST00000454757.6:c.1652C>T 7:g.55165344C>T EGFR ENST00000275493.6 3633 3236 2581351 2581351 2442606 lung left NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27923714 surgery - NOS primary 42 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045970 2045970 1926265 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163056 2163056 2031640 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264342 2264342 2131326 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1154573 1154573 1066909 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18946755 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 11-18 1656892 1571549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22313637 cell-line NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096184 2096184 1974248 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618634 1618634 1537386 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 81 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476883 2476883 2339652 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515238 1515238 1437848 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522887 1522887 1445259 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777402 1777402 1681405 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878853 2878853 2733368 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27368130 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1053138 1053138 969209 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17409961 surgery - NOS NS 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025406 2025406 1907495 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515251 1515251 1437861 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770695 1770695 1674935 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105819 2105819 1983857 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264122 2264122 2131106 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618767 1618767 1537519 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 50 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014306 1014306 931480 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142113 2142113 2011331 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422930 2422930 2285852 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844508 1844508 1737542 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23154768 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345579 2345579 2210251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029008 2029008 1910890 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008930 2008930 1891664 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22391431 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2865567 2865567 2720697 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29120087 surgery-fixed primary 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469862 1469862 1393601 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921885 1921885 1809203 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345374 2345374 2210046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770557 1770557 1674797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914903 1914903 1802905 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264106 2264106 2131090 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469354 1469354 1393093 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345370 2345370 2210042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1878634 1878634 1769195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23407566 surgery - NOS primary 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1512562 1512562 1435246 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21362302 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469867 1469867 1393606 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264145 2264145 2131129 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1746660 1746660 1651636 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246708 1246708 1158387 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1932132 1932132 1819405 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23632273 surgery fresh/frozen metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637187 1637187 1553235 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1201401 1201401 1113291 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19357847 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879521 1879521 1770023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 56 2760164 2618697 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51776282 COSM1168015 133202278 c.2123C>T p.P708L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Reported in another cancer sample as somatic 29876005 surgery-fixed NS ENSP00000415559.1:p.Pro708Leu ENST00000455089.5:c.2123C>T 7:g.55174795C>T EGFR ENST00000275493.6 3633 3236 1047954 1047954 964182 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 17337084 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345080 2345080 2209752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1914965 1914965 1802967 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2264370 2264370 2131354 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1638746 1638746 1554745 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000242 2000242 1885140 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246633 1246633 1158312 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637097 1637097 1553145 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921921 1921921 1809239 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096110 2096110 1974174 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264167 2264167 2131151 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105830 2105830 1983868 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425767 2425767 2288688 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011158 2011158 1893796 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731103 1731103 1637074 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22815900 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2082007 2082007 1960429 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24443522 surgery - NOS NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469378 1469378 1393117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862077 2862077 2717282 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 32122695 circulating tumour metastasis 62 ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 HN_62995 1560583 1482033 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825459 COSM122789 99385632 c.1423A>G p.I475V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Reported in another cancer sample as somatic 21798893 surgery fresh/frozen primary ENSP00000275493.2:p.Ile475Val ENST00000275493.6:c.1423A>G 7:g.55160263A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1063627 1063627 979672 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1029370 1029370 946241 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 17156891 surgery - NOS NS 49 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2680496 2680496 2539769 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 66 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1487187 1487187 1410797 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 21317742 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 P-0004491-T01-IM5 2720890 2579711 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28481359 surgery - NOS primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924777 924777 841550 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51863722 COSM13560 132565532 c.1736G>T p.C579F Substitution - Missense het 38 7:55165428-55165428 + - PATHOGENIC .99905 Reported in another cancer sample as somatic 16133419 NS NS ENSP00000395243.3:p.Cys579Phe ENST00000454757.6:c.1736G>T 7:g.55165428G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005580-T01-IM5 2721973 2580794 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450877 1450877 1375020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 49 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875797 1875797 1766380 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1109733 1109733 1023643 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18372921 surgery-fixed primary 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1668456 1668456 1581749 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1077337 1077337 992591 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453493 1453493 1377526 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1047006 1047006 963237 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1593017 1593017 1513943 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136875 1136875 1049439 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450873 1450873 1375016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2009158 2009158 1891892 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1090039 1090039 1004986 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17945377 surgery - NOS NS 32 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1188172 1188172 1100071 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19253367 surgery-fixed primary 77 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897843 897843 815465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 H1975 2776253 2634389 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29681454 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1047004 1047004 963235 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895131 1895131 1783823 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1200919 1200919 1112809 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19353773 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302271 1302271 1213322 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1990910 1990910 1876245 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899346 899346 816958 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PF08 2560049 2421473 large_intestine colon sigmoid NS adenoma tubular NS NS n COSV51779162 COSM21689 133203297 c.1652C>T p.P551L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 27609830 surgery-fixed NS ENSP00000415559.1:p.Pro551Leu ENST00000455089.5:c.1652C>T 7:g.55165344C>T EGFR ENST00000275493.6 3633 3236 1566947 1566947 1488716 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51804843 COSM12429 99380902 c.2573_2574delinsGT p.L858R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 21953075 surgery fresh/frozen metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573_2574delinsGT 7:g.55191822_55191823delinsGT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1566947 1566947 1488716 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51804843 COSM12429 133209145 c.2438_2439delinsGT p.L813R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 21953075 surgery fresh/frozen metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438_2439delinsGT 7:g.55191822_55191823delinsGT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GCYC_157_T 2747576 2606279 stomach NS NS NS carcinoma NS NS NS y COSV99286174 COSM8511928 133245865 c.2329G>A p.A777T Substitution - Missense 38 7:55181473-55181473 + - PATHOGENIC .97334 Confirmed somatic variant 683 NS primary ENSP00000415559.1:p.Ala777Thr ENST00000455089.5:c.2329G>A 7:g.55181473G>A EGFR ENST00000275493.6 3633 3236 1302275 1302275 1213326 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891234 1891234 1780603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983693 1983693 1869929 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2148644 2148644 2017774 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891300 1891300 1780669 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1974001 1974001 1860243 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51818388 COSM53104 133232583 c.2255G>A p.C752Y Substitution - Missense 38 7:55181399-55181399 + - PATHOGENIC .98244 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000415559.1:p.Cys752Tyr ENST00000455089.5:c.2255G>A 7:g.55181399G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 015 2640419 2500721 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 27545006 fixed - NOS NS 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2629466 2629466 2489850 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51797168 COSM87247 99408741 c.2587G>A p.G863S Substitution - Missense 38 7:55191836-55191836 + - PATHOGENIC .94673 Reported in another cancer sample as somatic 26317919 surgery-fixed NS 72 ENSP00000275493.2:p.Gly863Ser ENST00000275493.6:c.2587G>A 7:g.55191836G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891312 1891312 1780681 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1469946 1469946 1393685 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 20522446 surgery-fixed NS 81 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891317 1891317 1780686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732918 2732918 2591671 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 39 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1879549 1879549 1770051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1980069 1980069 1866312 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 73 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 H1975 2776253 2634389 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29681454 NS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879510 1879510 1770012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1980067 1980067 1866310 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 68 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 V153 1179732 1091694 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879516 1879516 1770018 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1242317 1242317 1154047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777111 COSM33725 132559461 c.2474A>G p.H825R Substitution - Missense hom 38 7:55191858-55191858 + - PATHOGENIC .97748 Reported in another cancer sample as somatic 19671738 surgery - NOS metastasis 56 ENSP00000395243.3:p.His825Arg ENST00000454757.6:c.2474A>G 7:g.55191858A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-50-6595-01 1780173 1684172 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 74 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-50-6595-01 1780173 1684172 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 74 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1668469 1668469 1581762 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780766 COSM219795 99373292 c.2591C>T p.A864V Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .93098 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Ala864Val ENST00000275493.6:c.2591C>T 7:g.55191840C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2772829 2772829 2631011 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 29594878 surgery - NOS NS 89 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479943 1479943 1403603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1513416 1513416 1436077 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21497370 fixed - NOS metastasis ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 907082 907082 824594 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 P-0004119-T01-IM5 2720520 2579341 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 99380629 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg252Cys ENST00000275493.6:c.754C>T 7:g.55154017C>T EGFR ENST00000275493.6 3633 3236 2083113 2083113 1961534 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 24300726 surgery-fixed NS ENSP00000275493.2:p.Glu709Lys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 11-18-ER1-7 1731373 1637339 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22815900 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891289 1891289 1780658 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453418 1453418 1377451 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1093894 1093894 1008596 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18061305 pleural effusion NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875355 1875355 1765938 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891188 1891188 1780557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1093895 1093895 1008597 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18061305 pleural effusion NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450864 1450864 1375007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983691 1983691 1869927 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1135416 1135416 1047980 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453419 1453419 1377452 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891281 1891281 1780650 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895074 1895074 1783766 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593001 1593001 1513927 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098814 1098814 1013406 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 57 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895127 1895127 1783819 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875368 1875368 1765951 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1500179 1500179 1423058 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899312 899312 816924 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891313 1891313 1780682 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450941 1450941 1375084 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 53 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429324 1429324 1338775 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1625786 1625786 1543010 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1160967 1160967 1073303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19002495 surgery-fixed primary 61 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875350 1875350 1765933 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453487 1453487 1377520 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136883 1136883 1049447 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990894 1990894 1876229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P92 1179743 1091705 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 52 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1000052 1000052 917275 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 911618 911618 829101 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479941 1479941 1403601 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043865 1043865 960206 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1168013 1168013 1080255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891227 1891227 1780596 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 HCC4011 2776306 2634442 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29681454 NS NS 53 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043873 1043873 960214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089134 1089134 1004088 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895162 1895162 1783854 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1075000 1075000 990254 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064717 2064717 1944794 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920151 920151 837231 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 81 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1000050 1000050 917273 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1074949 1074949 990203 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 71 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0649 2107982 1985843 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51791901 COSM2151461 133242102 c.856G>A p.G286R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .96902 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Gly286Arg ENST00000455089.5:c.856G>A 7:g.55155931G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1974001 1974001 1860243 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51818388 COSM53104 132574245 c.2255G>A p.C752Y Substitution - Missense 38 7:55181399-55181399 + - PATHOGENIC .98244 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000395243.3:p.Cys752Tyr ENST00000454757.6:c.2255G>A 7:g.55181399G>A EGFR ENST00000275493.6 3633 3236 pros_01_dx 2688203 2547185 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 544 NS primary 41 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103807 1103807 1018059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 NGS010 2875911 2730426 prostate NS NS NS carcinoma NS NS NS n COSV51792018 COSM4992972 99378183 c.3134C>T p.S1045F Substitution - Missense 38 7:55201754-55201754 + - PATHOGENIC .97067 Reported in another cancer sample as somatic 31580249 surgery-fixed NS ENSP00000275493.2:p.Ser1045Phe ENST00000275493.6:c.3134C>T 7:g.55201754C>T EGFR ENST00000275493.6 3633 3236 1547782 1547782 1469904 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 fine needle aspirate recurrent 42 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2402478 2402478 2265334 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 60 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2865238 2865238 2720368 lung left_upper_lobe NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 30828454 surgery - NOS metastasis 59 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1031900 1031900 948691 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 17085664 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2665672 2665672 2525381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28978102 surgery - NOS metastasis 34 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009157 2009157 1891891 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862726 2862726 2717889 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897839 897839 815461 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2156367 2156367 2025375 lung left_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24752053 surgery - NOS metastasis 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 7 1433972 1343387 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899313 899313 816925 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1931638 1931638 1818928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1549838 1549838 1471943 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891216 1891216 1780585 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891273 1891273 1780642 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1931645 1931645 1818935 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897842 897842 815464 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983749 1983749 1869985 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067074 1067074 983054 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668446 1668446 1581739 lung right_upper_lobe NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22526156 surgery-fixed primary 52 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1695798 1695798 1604010 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22670114 surgery - NOS NS 78 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1746650 1746650 1651626 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 68 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1498634 1498634 1421512 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21315472 surgery - NOS metastasis 55 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2260320 2260320 2127305 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25263855 fine needle aspirate NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618616 1618616 1537368 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 77 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469821 1469821 1393560 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2594472 2594472 2455348 lung right_upper_lobe NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 28178168 pleural effusion recurrent 76 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1468089 1468089 1391935 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2163019 2163019 2031603 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 V153 1179732 1091694 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2147916 2147916 2017059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 55 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983780 1983780 1870016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136867 1136867 1049431 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098983 1098983 1013575 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51779291 COSM26446 133217001 c.2389A>G p.N797D Substitution - Missense 38 7:55191773-55191773 + - PATHOGENIC .986 Reported in another cancer sample as somatic 18199332 surgery-fixed primary ENSP00000415559.1:p.Asn797Asp ENST00000455089.5:c.2389A>G 7:g.55191773A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 946823 946823 863346 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136872 1136872 1049436 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895098 1895098 1783790 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1047005 1047005 963236 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00004T00004 2857337 2712637 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 109594 2812900 2669314 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 66 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 IIIA 1179821 1091783 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19181917 surgery-fixed metastasis 27 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 898242 898242 815854 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 15728811 surgery-fixed recurrent 73 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103805 1103805 1018057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778769 2778769 2636823 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-08-0380-01 1910239 1798530 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779162 COSM21689 99374883 c.1787C>T p.P596L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 74 ENSP00000275493.2:p.Pro596Leu ENST00000275493.6:c.1787C>T 7:g.55165344C>T EGFR ENST00000275493.6 3633 3236 MG-050-tumor 2818996 2675295 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00443T00443 2857349 2712649 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2862785 2862785 2717948 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668458 1668458 1581751 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453425 1453425 1377458 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1077338 1077338 992592 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920154 920154 837234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 49 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2009147 2009147 1891881 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891338 1891338 1780707 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924344 924344 841119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110469 1110469 1024347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1197350 1197350 1109245 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1631943 1631943 1548813 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098858 1098858 1013450 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1715001 1715001 1622580 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22710815 surgery-fixed primary 77 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1242317 1242317 1154047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19671738 surgery - NOS metastasis 56 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479953 1479953 1403613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226904 2226904 2094639 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891261 1891261 1780630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089596 1089596 1004543 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895099 1895099 1783791 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LCSC_1 946053 862579 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 946822 946822 863345 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1135419 1135419 1047983 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891275 1891275 1780644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1625796 1625796 1543020 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1517070 1517070 1439664 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 47 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891177 1891177 1780546 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625559 2625559 2485971 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 51 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899304 899304 816916 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453435 1453435 1377468 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453424 1453424 1377457 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089141 1089141 1004095 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899311 899311 816923 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 907087 907087 824599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895110 1895110 1783802 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 V141 1179746 1091708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 76 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1075910 1075910 991164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302270 1302270 1213321 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1042914 1042914 959255 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226917 2226917 2094652 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 ABC-1 946050 862576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1558205 1558205 1479576 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21835826 surgery - NOS metastasis 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879580 1879580 1770082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51796944 COSM28537 99382129 c.2560A>G p.T854A Substitution - Missense 38 7:55191809-55191809 + - PATHOGENIC .9858 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr854Ala ENST00000275493.6:c.2560A>G 7:g.55191809A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MG-198-tumor 2819083 2675382 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00178T00178 2857362 2712662 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 24 2570197 2431494 skin chest_wall NS NS adnexal_tumour sebaceous_carcinoma NS NS n COSV51794784 COSM13182 133203905 c.2068G>A p.G690S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 79 ENSP00000415559.1:p.Gly690Ser ENST00000455089.5:c.2068G>A 7:g.55174740G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879567 1879567 1770069 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2425771 2425771 2288692 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2096256 2096256 1974320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1312423 1312423 1223332 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 19723643 surgery-fixed NS 60 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1914967 1914967 1802969 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1522947 1522947 1445319 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 60 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879491 1879491 1769993 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1007074 1007074 924282 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 16410744 NS primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2539014 2539014 2400609 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 26749488 NS recurrent 57 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879522 1879522 1770024 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1513416 1513416 1436077 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21497370 fixed - NOS metastasis ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479943 1479943 1403603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2264433 2264433 2131417 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2241821 2241821 2109352 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25228365 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329261 1329261 1239746 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680702 2680702 2539975 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444714 1444714 1368957 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637196 1637196 1553244 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1465886 1465886 1389733 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 61 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-0829-01 2178136 2046434 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772147 COSM375343 132564558 c.1799C>G p.S600C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Confirmed somatic variant 329 NS NS 75 ENSP00000395243.3:p.Ser600Cys ENST00000454757.6:c.1799C>G 7:g.55172997C>G EGFR ENST00000275493.6 3633 3236 2406822 2406822 2269702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23709419 surgery - NOS NS 50 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2245041 2245041 2112317 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264219 2264219 2131203 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2078470 2078470 1957189 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014122 1014122 931296 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214544 2214544 2082668 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1284668 1284668 1195963 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16467085 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214531 2214531 2082655 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522891 1522891 1445263 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421211 2421211 2284133 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887379 1887379 1777051 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838664 1838664 1732765 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 916964 916964 834345 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16052537 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887397 1887397 1777069 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0237-01 1910211 1798502 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense hom 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 75 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897283 897283 814906 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15118073 surgery fresh/frozen primary 32 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1673287 1673287 1586341 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22225786 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591011 1591011 1512127 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515263 1515263 1437873 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096112 2096112 1974176 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096135 2096135 1974199 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965833 1965833 1852326 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1355122 1355122 1265217 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618971 1618971 1537693 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22019513 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549135 2549135 2410590 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095988 2095988 1974052 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1148667 1148667 1061108 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18829487 surgery-fixed NS 89 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1284667 1284667 1195962 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16467085 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095954 2095954 1974018 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705486 1705486 1613392 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142082 2142082 2011300 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887393 1887393 1777065 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535022 1535022 1457357 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2482735 2482735 2345462 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26893581 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218544 2218544 2086555 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2491466 2491466 2354112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26885207 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468880 1468880 1392619 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21128242 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1498637 1498637 1421515 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21315472 surgery - NOS primary 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770605 1770605 1674845 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551479 1551479 1473584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618616 1618616 1537368 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1599060 1599060 1519547 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22091430 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336833 1336833 1247218 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1029017 1029017 945888 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17075123 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587281 1587281 1508452 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469872 1469872 1393611 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205976 2205976 2074209 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591081 1591081 1512197 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2560136 2560136 2421560 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26826182 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083102 2083102 1961523 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24300726 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535044 1535044 1457379 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777281 1777281 1681284 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083113 2083113 1961534 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24300726 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729975 1729975 1635946 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734177 1734177 1640126 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22843912 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345392 2345392 2210064 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1531511 1531511 1453871 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21681119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2271428 2271428 2138059 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25257380 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983857 983857 899574 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16733218 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891300 1891300 1780669 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1705496 1705496 1613402 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2245051 2245051 2112327 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921884 1921884 1809202 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680671 2680671 2539944 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887425 1887425 1777097 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264433 2264433 2131417 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921898 1921898 1809216 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878784 2878784 2733299 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22006985 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-196-tumor 2819081 2675380 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453420 1453420 1377453 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891164 1891164 1780533 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450844 1450844 1374987 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 55 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1052728 1052728 968799 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17368623 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226895 2226895 2094630 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LUAD-NYU1101 1765169 1669489 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 72 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136892 1136892 1049456 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1162200 1162200 1074532 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302284 1302284 1213335 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983705 1983705 1869941 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1602802 1602802 1522138 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1549821 1549821 1471926 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897803 897803 815425 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875366 1875366 1765949 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 924342 924342 841117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1160966 1160966 1073302 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19002495 surgery-fixed primary 50 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166418 1166418 1078732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51843707 COSM28601 132551449 c.2000T>C p.F667S Substitution - Missense het 38 7:55173994-55173994 + - PATHOGENIC .9621 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 59 ENSP00000395243.3:p.Phe667Ser ENST00000454757.6:c.2000T>C 7:g.55173994T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625556 2625556 2485968 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136882 1136882 1049446 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1576799 1576799 1498240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 79 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879531 1879531 1770033 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1024776 1024776 941753 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 pleural effusion recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1992086 1992086 1877403 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 50 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732934 2732934 2591687 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 72 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2432376 2432376 2295279 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 26473643 surgery fresh/frozen metastasis 53 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879577 1879577 1770079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891329 1891329 1780698 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 3615 915978 833377 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51789362 COSM13184 132574086 c.2101G>A p.E701K Substitution - Missense 38 7:55174773-55174773 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000395243.3:p.Glu701Lys ENST00000454757.6:c.2101G>A 7:g.55174773G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001303-T01-IM3 2717027 2575848 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51807743 COSM133179 132566093 c.1930G>A p.V644M Substitution - Missense het 38 7:55173924-55173924 + - PATHOGENIC .9843 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Val644Met ENST00000454757.6:c.1930G>A 7:g.55173924G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001303-T01-IM3 2717027 2575848 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862785 2862785 2717948 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 1891301 1891301 1780670 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1500584 1500584 1423463 stomach NS NS NS carcinoma mucinous_adenocarcinoma NS NS n COSV51778659 COSM14070 132547729 c.2453G>A p.G818D Substitution - Missense het 38 7:55191837-55191837 + - PATHOGENIC .92688 Reported in another cancer sample as somatic 21436633 surgery - NOS NS 76 ENSP00000395243.3:p.Gly818Asp ENST00000454757.6:c.2453G>A 7:g.55191837G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2841857 2841857 2697406 soft_tissue fibrous_tissue_and_uncertain_origin trunk NS desmoid_tumour-fibromatosis NS NS NS n COSV51777833 COSM4680394 132556268 c.1445G>A p.R482Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Reported in another cancer sample as somatic 32099073 surgery-fixed NS 27 ENSP00000395243.3:p.Arg482Gln ENST00000454757.6:c.1445G>A 7:g.55161580G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098814 1098814 1013406 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767386 COSM18423 132564484 c.2365G>T p.V789L Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .9903 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 57 ENSP00000395243.3:p.Val789Leu ENST00000454757.6:c.2365G>T 7:g.55191749G>T EGFR ENST00000275493.6 3633 3236 1531004 1531004 1453376 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2644126 2644126 2504413 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 28573640 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2664363 2664363 2524424 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 36 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1246729 1246729 1158408 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2402477 2402477 2265333 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 60 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668446 1668446 1581739 lung right_upper_lobe NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22526156 surgery-fixed primary 52 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1695798 1695798 1604010 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22670114 surgery - NOS NS 78 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004718-T01-IM5 2721121 2579942 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2772829 2772829 2631011 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 29594878 surgery - NOS NS 89 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1896936 1896936 1785623 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 23542356 surgery-fixed recurrent 88 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 S001067 1027687 944663 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 99378725 c.787A>C p.T263P Substitution - Missense hom 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Thr263Pro ENST00000275493.6:c.787A>C 7:g.55154050A>C EGFR ENST00000275493.6 3633 3236 1091711 1091711 1006533 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 1091711 1091711 1006533 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 AA3-12 2539111 2400700 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSM34166 178380439 c.? p.R108K Substitution - Missense + - Reported in another cancer sample as somatic 25257301 surgery-fixed NS ENSP00000275493.2:p.Arg108Lys EGFR ENST00000275493.6 3633 3236 1998739 1998739 1883811 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23937608 surgery-fixed primary 46 ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2840787 2840787 2696347 prostate NS NS NS carcinoma NS NS NS n COSV51785413 COSM1176673 132555528 c.620G>A p.R207H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000395243.3:p.Arg207His ENST00000454757.6:c.620G>A 7:g.55154018G>A EGFR ENST00000275493.6 3633 3236 1914918 1914918 1802920 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676417 1676417 1589185 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2110148 2110148 1986500 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24563335 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2115445 2115445 1989689 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23915069 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000254 2000254 1885152 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096138 2096138 1974202 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226165 2226165 2093900 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045998 2045998 1926293 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2147901 2147901 2017044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24707263 surgery - NOS metastasis 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421223 2421223 2284145 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476895 2476895 2339664 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618053 1618053 1536849 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618721 1618721 1537473 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120919 1120919 1034075 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430050 1430050 1339468 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1334739 1334739 1245124 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20401612 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096004 2096004 1974068 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838710 1838710 1732811 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591078 1591078 1512194 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045958 2045958 1926253 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096213 2096213 1974277 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083801 1083801 998966 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937576 1937576 1824510 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345462 2345462 2210134 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425722 2425722 2288643 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163638 2163638 2032131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24793378 surgery - NOS NS 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637700 2637700 2498073 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 circulating tumour recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874744 1874744 1765335 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264349 2264349 2131333 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1695714 1695714 1603926 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22673630 fine needle aspirate primary 47 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1053133 1053133 969204 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17409961 surgery - NOS NS 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469488 1469488 1393227 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777384 1777384 1681387 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469423 1469423 1393162 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587275 1587275 1508446 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1823849 1823849 1722243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23212424 surgery-fixed primary 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983114 983114 898832 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986156 1986156 1872392 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965847 1965847 1852340 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345570 2345570 2210242 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914931 1914931 1802933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474444 2474444 2337213 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469490 1469490 1393229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1135350 1135350 1047916 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17591931 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346535 2346535 2211198 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638747 1638747 1554746 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142105 2142105 2011323 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729956 1729956 1635927 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 surgery-fixed NS 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026260 2026260 1908349 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174298 1174298 1086317 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029021 2029021 1910903 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264166 2264166 2131150 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163041 2163041 2031625 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637101 1637101 1553149 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777222 1777222 1681225 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1855991 1855991 1748544 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1599064 1599064 1519551 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22091430 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965869 1965869 1852362 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011165 2011165 1893803 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479102 1479102 1402795 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921901 1921901 1809219 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1513412 1513412 1436073 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21497370 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1334741 1334741 1245126 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20401612 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515872 1515872 1438475 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21591457 surgery - NOS NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345513 2345513 2210185 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076937 2076937 1955686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed NS 48 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838689 1838689 1732790 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027792 2027792 1909695 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591045 1591045 1512161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637209 1637209 1553257 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469390 1469390 1393129 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777309 1777309 1681312 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770597 1770597 1674837 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965876 1965876 1852369 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046622 2046622 1926916 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838700 1838700 1732801 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921728 1921728 1809046 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense hom + - Reported in another cancer sample as somatic 23620765 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842986 1842986 1736234 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618972 1618972 1537694 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22019513 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045971 2045971 1926266 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096045 2096045 1974109 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096148 2096148 1974212 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2560119 2560119 2421543 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26826182 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842967 1842967 1736215 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1196957 1196957 1108852 lung NS NS NS other neoplasm NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19289583 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 11-18 1336877 1247262 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 cell-line NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964311 1964311 1850846 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096032 2096032 1974096 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668436 1668436 1581729 lung bronchus NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22526156 surgery-fixed primary 18 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2239187 2239187 2106719 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 48 ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 907082 907082 824594 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00237T00237 2857324 2712624 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S003763 1027686 944662 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 1618631 1618631 1537383 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1610410 1610410 1529650 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22142557 pleural effusion NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746670 1746670 1651646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 H1975 1513408 1436069 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21498706 cell-line NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481223 1481223 1404852 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2525724 2525724 2387912 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1994266 1994266 1879521 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23886169 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166430 1166430 1078744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773206 COSM28603 133217070 c.2158G>A p.V720M Substitution - Missense het 38 7:55181302-55181302 + - PATHOGENIC .97963 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 51 ENSP00000415559.1:p.Val720Met ENST00000455089.5:c.2158G>A 7:g.55181302G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1484300 1484300 1407926 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51778659 COSM14070 133202857 c.2453G>A p.G818D Substitution - Missense 38 7:55191837-55191837 + - PATHOGENIC .92688 Reported in another cancer sample as somatic 21266046 surgery-fixed primary 66 ENSP00000415559.1:p.Gly818Asp ENST00000455089.5:c.2453G>A 7:g.55191837G>A EGFR ENST00000275493.6 3633 3236 907082 907082 824594 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876039 2876039 2730554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876039 2876039 2730554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 66 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-17-X19682 2905664 2759920 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51824002 COSM6937752 133229963 c.2659C>T p.R887C Substitution - Missense 38 7:55198809-55198809 + - PATHOGENIC .91422 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000415559.1:p.Arg887Cys ENST00000455089.5:c.2659C>T 7:g.55198809C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732912 2732912 2591665 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 133205223 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 60 ENSP00000415559.1:p.Ala244Asp ENST00000455089.5:c.731C>A 7:g.55154129C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 104 2786511 2643934 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51780877 COSM26717 132548732 c.2444A>T p.K815I Substitution - Missense 38 7:55191828-55191828 + - PATHOGENIC .95726 Reported in another cancer sample as somatic 30115035 surgery-fixed NS ENSP00000395243.3:p.Lys815Ile ENST00000454757.6:c.2444A>T 7:g.55191828A>T EGFR ENST00000275493.6 3633 3236 1592970 1592970 1513896 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773111 COSM13185 99375118 c.2252C>T p.T751I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Thr751Ile ENST00000275493.6:c.2252C>T 7:g.55174789C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372590 2372590 2235383 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593005 1593005 1513931 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897832 897832 815454 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064715 2064715 1944792 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1610922 1610922 1530150 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22157931 pleural effusion NS 61 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860416 1860416 1751357 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895157 1895157 1783849 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1320682 1320682 1231569 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20155428 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1625795 1625795 1543019 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226894 2226894 2094629 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899318 899318 816930 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136870 1136870 1049434 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862720 2862720 2717883 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450846 1450846 1374989 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 44 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897826 897826 815448 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GCYC_157_T 2747576 2606279 stomach NS NS NS carcinoma NS NS NS y COSV99286174 COSM8511928 132584621 c.2329G>A p.A777T Substitution - Missense 38 7:55181473-55181473 + - PATHOGENIC .97334 Confirmed somatic variant 683 NS primary ENSP00000395243.3:p.Ala777Thr ENST00000454757.6:c.2329G>A 7:g.55181473G>A EGFR ENST00000275493.6 3633 3236 A103-T-S25 2757418 2616003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2345803 2345803 2210475 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1093894 1093894 1008596 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 18061305 pleural effusion NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 TCGA-BS-A0UV-01 1783478 1687477 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51773524 COSM1090858 99375990 c.418T>G p.L140V Substitution - Missense het 38 7:55143482-55143482 + - NEUTRAL .25717 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 55 ENSP00000275493.2:p.Leu140Val ENST00000275493.6:c.418T>G 7:g.55143482T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2064707 2064707 1944784 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899335 899335 816947 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983734 1983734 1869970 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2479711 2479711 2342457 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302277 1302277 1213328 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226873 2226873 2094608 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067076 1067076 983056 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1083996 1083996 999161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17785547 surgery fresh/frozen primary 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-50-5944-01 1780167 1684166 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2733662 2733662 2592415 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29721166 cerebrospinal fluid metastasis 71 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875800 1875800 1766383 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897841 897841 815463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005361 1005361 922573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1202557 1202557 1114443 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1882520 1882520 1772655 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23486266 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264213 2264213 2131197 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163055 2163055 2031639 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230485 1230485 1142299 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096141 2096141 1974205 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246622 1246622 1158301 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173395 1173395 1085479 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278199 1278199 1189497 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421230 2421230 2284152 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105820 2105820 1983858 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 NCI-H3255 1028937 945808 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17145836 cell-line NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535052 1535052 1457387 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2439549 2439549 2302389 lung NS NS NS carcinoma invasive_mucinous_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24119562 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777283 1777283 1681286 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734087 1734087 1640036 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22842370 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264192 2264192 2131176 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2007101 2007101 1889982 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23790173 surgery-fixed NS 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228295 2228295 2096015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774667 1774667 1678891 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS primary 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047818 2047818 1928090 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095906 2095906 1973970 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 914884 914884 832333 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 15899142 surgery-fixed NS 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1896936 1896936 1785623 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23542356 surgery-fixed recurrent 88 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777236 1777236 1681239 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336425 1336425 1246810 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20430469 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879519 1879519 1770021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2239182 2239182 2106714 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 25130612 fine needle aspirate NS 48 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879546 1879546 1770048 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239182 2239182 2106714 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 fine needle aspirate NS 48 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1627722 1627722 1544634 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110461 1110461 1024339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226881 2226881 2094616 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983751 1983751 1869987 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1097645 1097645 1012306 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777403 1777403 1681406 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011153 2011153 1893791 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2209392 2209392 2077625 lung NS NS NS carcinoma signet_ring_cell_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25007143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1732971 1732971 1638920 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22833420 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469482 1469482 1393221 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444710 1444710 1368953 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459766 1459766 1383709 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21062932 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459507 1459507 1383450 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475385 1475385 1399084 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535029 1535029 1457364 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469385 1469385 1393124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777390 1777390 1681393 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083793 1083793 998958 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1097647 1097647 1012308 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547813 1547813 1469935 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed metastasis 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1855997 1855997 1748550 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680735 2680735 2540008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2033589 2033589 1915038 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24137397 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887408 1887408 1777080 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549148 2549148 2410603 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838718 1838718 1732819 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346546 2346546 2211209 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964310 1964310 1850845 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425762 2425762 2288683 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096164 2096164 1974228 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106555 2106555 1984418 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 H1975 1513408 1436069 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21498706 cell-line NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026255 2026255 1908344 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203114 2203114 2071372 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618889 1618889 1537641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141333 1141333 1053781 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345399 2345399 2210071 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965825 1965825 1852318 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965830 1965830 1852323 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1892648 1892648 1781900 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23566546 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027791 2027791 1909694 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142054 2142054 2011272 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 SNU-C2B 2302010 2167293 large_intestine colon right NS carcinoma adenocarcinoma NS NS y COSV51777851 COSM1205052 99395067 c.494G>A p.R165Q Substitution - Missense het 38 7:55146675-55146675 + - NEUTRAL .0375 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000275493.2:p.Arg165Gln ENST00000275493.6:c.494G>A 7:g.55146675G>A EGFR ENST00000275493.6 3633 3236 1876995 1876995 1767557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23419122 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2878946 2878946 2733461 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 33115932 surgery-fixed NS 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891293 1891293 1780662 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875342 1875342 1765925 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166418 1166418 1078732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51815934 COSM28607 132551460 c.2468A>G p.E823G Substitution - Missense het 38 7:55191852-55191852 + - PATHOGENIC .96745 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 59 ENSP00000395243.3:p.Glu823Gly ENST00000454757.6:c.2468A>G 7:g.55191852A>G EGFR ENST00000275493.6 3633 3236 1000059 1000059 917282 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1231315 1231315 1143105 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1168012 1168012 1080254 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1103759 1103759 1018011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18261621 surgery-fixed primary 76 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LK-2 946071 862597 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924523 924523 841296 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16043828 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1789304 1789304 1692708 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23026641 bronchoalveolar lavage fluid primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1881377 1881377 1771528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2009146 2009146 1891880 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1451205 1451205 1375348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20855974 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875362 1875362 1765945 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1541734 1541734 1464038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21469767 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897838 897838 815460 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2026240 2026240 1908329 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230492 1230492 1142306 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096058 2096058 1974122 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1673295 1673295 1586349 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22225786 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264207 2264207 2131191 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587264 1587264 1508435 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2011156 2011156 1893794 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346542 2346542 2211205 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887416 1887416 1777088 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1202162 1202162 1114048 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19371962 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345508 2345508 2210180 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638775 1638775 1554774 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148625 2148625 2017755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921914 1921914 1809232 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451760 1451760 1375809 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20615575 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1278203 1278203 1189501 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19777258 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777268 1777268 1681271 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081929 2081929 1960351 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24440279 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1585322 1585322 1506643 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22011666 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777409 1777409 1681412 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083062 1083062 998227 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17685931 surgery-fixed NS 81 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637131 1637131 1553179 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1990915 1990915 1876250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1295829 1295829 1206901 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19640859 fine needle aspirate primary 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1135421 1135421 1047985 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983718 1983718 1869954 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899331 899331 816943 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1627727 1627727 1544639 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1074889 1074889 990143 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17505415 surgery fresh/frozen primary 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1089139 1089139 1004093 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1541731 1541731 1464035 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21469767 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0185-01 1910194 1798485 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774819 COSM35840 132552089 c.1816G>A p.V606M Substitution - Missense het 38 7:55173014-55173014 + - PATHOGENIC .99458 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 54 ENSP00000395243.3:p.Val606Met ENST00000454757.6:c.1816G>A 7:g.55173014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2841131 2841131 2696691 prostate NS NS NS carcinoma NS NS NS n COSV51862598 COSM6938266 132547606 c.1889G>A p.R630Q Substitution - Missense 38 7:55173087-55173087 + - PATHOGENIC .98305 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000395243.3:p.Arg630Gln ENST00000454757.6:c.1889G>A 7:g.55173087G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00173T00173 2857372 2712672 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-070-tumor 2819006 2675305 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1136878 1136878 1049442 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602808 1602808 1522144 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899326 899326 816938 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983744 1983744 1869980 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1593020 1593020 1513946 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891223 1891223 1780592 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226878 2226878 2094613 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897806 897806 815428 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2027349 2027349 1909417 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2878948 2878948 2733463 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 33115932 surgery-fixed NS 65 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1038994 1038994 955571 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2161696 2161696 2030303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24813888 pleural effusion NS 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1434028 1434028 1343443 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2372591 2372591 2235384 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2482738 2482738 2345465 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 26893581 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345076 2345076 2209748 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982887 982887 898606 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 56 2760164 2618697 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51776282 COSM1168015 132547141 c.2123C>T p.P708L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Reported in another cancer sample as somatic 29876005 surgery-fixed NS ENSP00000395243.3:p.Pro708Leu ENST00000454757.6:c.2123C>T 7:g.55174795C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 56 2760164 2618697 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51796850 COSM24846 132580433 c.2356C>T p.R786C Substitution - Missense 38 7:55191740-55191740 + - PATHOGENIC .9406 Reported in another cancer sample as somatic 29876005 surgery-fixed NS ENSP00000395243.3:p.Arg786Cys ENST00000454757.6:c.2356C>T 7:g.55191740C>T EGFR ENST00000275493.6 3633 3236 1593015 1593015 1513941 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1566947 1566947 1488716 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51804843 COSM12429 132553900 c.2438_2439delinsGT p.L813R Substitution - Missense 38 7:55191822-55191823 + - Reported in another cancer sample as somatic 21953075 surgery fresh/frozen metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438_2439delinsGT 7:g.55191822_55191823delinsGT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042861 1042861 959202 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166432 1166432 1078746 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51815934 COSM28607 132551460 c.2468A>G p.E823G Substitution - Missense hom 38 7:55191852-55191852 + - PATHOGENIC .96745 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 59 ENSP00000395243.3:p.Glu823Gly ENST00000454757.6:c.2468A>G 7:g.55191852A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 4990 915974 833373 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51802602 COSM13181 133220811 c.2063C>T p.P688L Substitution - Missense 38 7:55174735-55174735 + - PATHOGENIC .99806 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000415559.1:p.Pro688Leu ENST00000455089.5:c.2063C>T 7:g.55174735C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 3595 915982 833381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51775222 COSM13189 132558076 c.2216C>T p.S739F Substitution - Missense 38 7:55181360-55181360 + - PATHOGENIC .94833 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000395243.3:p.Ser739Phe ENST00000454757.6:c.2216C>T 7:g.55181360C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862176 2862176 2717378 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51862598 COSM6938266 133202738 c.1889G>A p.R630Q Substitution - Missense 38 7:55173087-55173087 + - PATHOGENIC .98305 Confirmed somatic variant 27873319 surgery fresh/frozen NS 77 ENSP00000415559.1:p.Arg630Gln ENST00000455089.5:c.1889G>A 7:g.55173087G>A EGFR ENST00000275493.6 3633 3236 EXTERN_MELA_20140526_088 2839362 2695128 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 99380065 c.1168C>A p.Q390K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000275493.2:p.Gln390Lys ENST00000275493.6:c.1168C>A 7:g.55156793C>A EGFR ENST00000275493.6 3633 3236 1500584 1500584 1423463 stomach NS NS NS carcinoma mucinous_adenocarcinoma NS NS n COSV51778659 COSM14070 99374271 c.2588G>A p.G863D Substitution - Missense het 38 7:55191837-55191837 + - PATHOGENIC .92688 Reported in another cancer sample as somatic 21436633 surgery - NOS NS 76 ENSP00000275493.2:p.Gly863Asp ENST00000275493.6:c.2588G>A 7:g.55191837G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S001108 1027693 944669 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 17177598 cell-line NS ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1576801 1576801 1498242 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 62 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0004496-T01-IM5 2720895 2579716 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1576804 1576804 1498245 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 surgery - NOS primary 64 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879558 1879558 1770060 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1891324 1891324 1780693 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1465900 1465900 1389747 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 62 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1591015 1591015 1512131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DCR9 1690658 1598935 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 133216830 c.1341C>A p.S447R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000415559.1:p.Ser447Arg ENST00000455089.5:c.1341C>A 7:g.55160316C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879521 1879521 1770023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 S003763 1027686 944662 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 106 898382 815994 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1047955 1047955 964183 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 17337084 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862077 2862077 2717282 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 32122695 circulating tumour metastasis 62 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-50-6595-01 1780173 1684172 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 74 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479953 1479953 1403613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767182 COSM27110 132554778 c.2221G>A p.V741M Substitution - Missense 38 7:55181365-55181365 + - PATHOGENIC .97319 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Val741Met ENST00000454757.6:c.2221G>A 7:g.55181365G>A EGFR ENST00000275493.6 3633 3236 1103630 1103630 1017882 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920160 920160 837240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 47 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983706 1983706 1869942 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983786 1983786 1870022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891250 1891250 1780619 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1166443 1166443 1078757 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1541735 1541735 1464039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21469767 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1089136 1089136 1004090 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1593004 1593004 1513930 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226897 2226897 2094632 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043128 1043128 959469 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51782403 COSM22951 133242202 c.2249T>C p.F750S Substitution - Missense 38 7:55181393-55181393 + - .67484 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 76 ENSP00000415559.1:p.Phe750Ser ENST00000455089.5:c.2249T>C 7:g.55181393T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 24 897185 814808 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2555799 2555799 2417236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 26599269 surgery - NOS NS 58 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479943 1479943 1403603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC130 2439290 2302131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780429 COSM710350 132557726 c.2477C>T p.A826V Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .97911 Reported in another cancer sample as somatic 26164066 surgery-fixed metastasis ENSP00000395243.3:p.Ala826Val ENST00000454757.6:c.2477C>T 7:g.55191861C>T EGFR ENST00000275493.6 3633 3236 1471794 1471794 1395532 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1530670 1530670 1453042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21227397 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1435991 1435991 1345270 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen primary 85 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924334 924334 841109 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2009164 2009164 1891898 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875805 1875805 1766388 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1990908 1990908 1876243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1435995 1435995 1345274 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery-fixed primary 59 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602815 1602815 1522151 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1089600 1089600 1004547 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1694963 1694963 1603183 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22615840 surgery-fixed NS 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1990907 1990907 1876242 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862729 2862729 2717892 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110467 1110467 1024345 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897835 897835 815457 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1500588 1500588 1423467 stomach NS NS NS carcinoma mucinous_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21436633 surgery - NOS NS 76 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1110460 1110460 1024338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875371 1875371 1765954 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1479934 1479934 1403594 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1884153 1884153 1774040 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450849 1450849 1374992 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1075923 1075923 991177 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067067 1067067 983047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862717 2862717 2717880 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1714997 1714997 1622576 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22710815 surgery-fixed primary 77 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1751707 1751707 1656523 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226875 2226875 2094610 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1202561 1202561 1114447 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899315 899315 816927 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891254 1891254 1780623 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897831 897831 815453 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862077 2862077 2717282 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 32122695 circulating tumour metastasis 62 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-18-T40375 2905680 2759936 NS NS NS NS malignant_melanoma NS NS NS n COSV51816692 COSM6503372 133234498 c.2905G>A p.D969N Substitution - Missense 38 7:55201281-55201281 + - PATHOGENIC .99528 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Asp969Asn ENST00000455089.5:c.2905G>A 7:g.55201281G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5313 915983 833382 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51860329 COSM13190 132563568 c.2240T>C p.L747P Substitution - Missense 38 7:55181384-55181384 + - PATHOGENIC .95089 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000395243.3:p.Leu747Pro ENST00000454757.6:c.2240T>C 7:g.55181384T>C EGFR ENST00000275493.6 3633 3236 1310475 1310475 1221420 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899338 899338 816950 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1668553 1668553 1581846 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2539013 2539013 2400608 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 26749488 NS metastasis 57 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983745 1983745 1869981 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1648545 1648545 1563500 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1625784 1625784 1543008 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1305391 1305391 1216439 lung NS NS NS carcinoma oncocytic_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20023269 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226900 2226900 2094635 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1517067 1517067 1439661 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 59 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302287 1302287 1213338 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-18-K32111 2905107 2759363 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226866 2226866 2094601 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1990903 1990903 1876238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S25 1063224 979269 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983746 1983746 1869982 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1981033 1981033 1867269 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453498 1453498 1377531 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2396138 2396138 2258969 lung left_bronchus NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24942894 fine needle aspirate primary 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1625785 1625785 1543009 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0649 2107982 1985843 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51791901 COSM2151461 132581011 c.856G>A p.G286R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .96902 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Gly286Arg ENST00000454757.6:c.856G>A 7:g.55155931G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625598 2625598 2486010 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 44 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2841814 2841814 2697363 soft_tissue fibrous_tissue_and_uncertain_origin abdomen NS desmoid_tumour-fibromatosis NS NS NS n COSV99290440 COSM7410173 132582578 c.3038G>A p.C1013Y Substitution - Missense 38 7:55202527-55202527 + - NEUTRAL .29295 Reported in another cancer sample as somatic 32099073 surgery-fixed NS 27 ENSP00000395243.3:p.Cys1013Tyr ENST00000454757.6:c.3038G>A 7:g.55202527G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2566146 2566146 2427537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 27794398 surgery-fixed NS 74 ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592890 1592890 1513816 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51802602 COSM13181 132564438 c.2063C>T p.P688L Substitution - Missense 38 7:55174735-55174735 + - PATHOGENIC .99806 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Pro688Leu ENST00000454757.6:c.2063C>T 7:g.55174735C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194731 1194731 1106626 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732912 2732912 2591665 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 132550339 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 60 ENSP00000395243.3:p.Ala244Asp ENST00000454757.6:c.731C>A 7:g.55154129C>A EGFR ENST00000275493.6 3633 3236 1980071 1980071 1866314 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23721103 blood-bone marrow recurrent 61 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1235125 1235125 1146911 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19589612 surgery - NOS metastasis 58 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1590011 1590011 1511165 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21995391 surgery-fixed recurrent 55 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2422465 2422465 2285387 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25521406 surgery - NOS metastasis 56 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2566146 2566146 2427537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 27794398 surgery-fixed NS 74 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2757125 2757125 2615768 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 29858019 circulating tumour recurrent 50 ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098983 1098983 1013575 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51779291 COSM26446 132560907 c.2389A>G p.N797D Substitution - Missense 38 7:55191773-55191773 + - PATHOGENIC .986 Reported in another cancer sample as somatic 18199332 surgery-fixed primary ENSP00000395243.3:p.Asn797Asp ENST00000454757.6:c.2389A>G 7:g.55191773A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2841131 2841131 2696691 prostate NS NS NS carcinoma NS NS NS n COSV51862598 COSM6938266 133202738 c.1889G>A p.R630Q Substitution - Missense 38 7:55173087-55173087 + - PATHOGENIC .98305 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000415559.1:p.Arg630Gln ENST00000455089.5:c.1889G>A 7:g.55173087G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732925 2732925 2591678 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 75 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LUAD-NYU1093 1765123 1669443 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 61 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1592890 1592890 1513816 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51802602 COSM13181 99393727 c.2198C>T p.P733L Substitution - Missense 38 7:55174735-55174735 + - PATHOGENIC .99806 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Pro733Leu ENST00000275493.6:c.2198C>T 7:g.55174735C>T EGFR ENST00000275493.6 3633 3236 2026144 2026144 1908233 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Glu709Lys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891317 1891317 1780686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879516 1879516 1770018 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1063627 1063627 979672 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862077 2862077 2717282 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 32122695 circulating tumour metastasis 62 ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 V153 1179732 1091694 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2156367 2156367 2025375 lung left_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24752053 surgery - NOS metastasis 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897839 897839 815461 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067074 1067074 983054 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009157 2009157 1891891 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1931638 1931638 1818928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136872 1136872 1049436 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862726 2862726 2717889 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1931645 1931645 1818935 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899313 899313 816925 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983780 1983780 1870016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924777 924777 841550 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51863722 COSM13560 99395587 c.1871G>T p.C624F Substitution - Missense het 38 7:55165428-55165428 + - PATHOGENIC .99905 Reported in another cancer sample as somatic 16133419 NS NS ENSP00000275493.2:p.Cys624Phe ENST00000275493.6:c.1871G>T 7:g.55165428G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897842 897842 815464 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2147916 2147916 2017059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 55 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 V153 1179732 1091694 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 7 1433972 1343387 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891216 1891216 1780585 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895098 1895098 1783790 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891273 1891273 1780642 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1549838 1549838 1471943 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1047005 1047005 963236 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983749 1983749 1869985 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 946823 946823 863346 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136867 1136867 1049431 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0005580-T01-IM5 2721973 2580794 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2096227 2096227 1974291 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2096228 2096228 1974292 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1637265 1637265 1553313 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1914963 1914963 1802965 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BL-18-T40375 2905680 2759936 NS NS NS NS malignant_melanoma NS NS NS n COSV51830943 COSM3639753 133242786 c.2629G>A p.E877K Substitution - Missense 38 7:55198779-55198779 + - PATHOGENIC .98622 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000415559.1:p.Glu877Lys ENST00000455089.5:c.2629G>A 7:g.55198779G>A EGFR ENST00000275493.6 3633 3236 2226908 2226908 2094643 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2525697 2525697 2387886 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 27304188 surgery-fixed metastasis ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897781 897781 815403 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1450865 1450865 1375008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 77 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2156365 2156365 2025374 lung left_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24752053 surgery - NOS primary 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1047001 1047001 963232 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899305 899305 816917 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 899341 899341 816953 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226906 2226906 2094641 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136891 1136891 1049455 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166444 1166444 1078758 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1860431 1860431 1751372 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659809 2659809 2519967 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1429296 1429296 1338747 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920131 920131 837211 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1202560 1202560 1114446 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1592992 1592992 1513918 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593019 1593019 1513945 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1302276 1302276 1213327 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1576799 1576799 1498240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 79 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879531 1879531 1770033 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 56 2760164 2618697 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51796850 COSM24846 99415765 c.2491C>T p.R831C Substitution - Missense 38 7:55191740-55191740 + - PATHOGENIC .9406 Reported in another cancer sample as somatic 29876005 surgery-fixed NS ENSP00000275493.2:p.Arg831Cys ENST00000275493.6:c.2491C>T 7:g.55191740C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1007074 1007074 924282 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 16410744 NS primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879522 1879522 1770024 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2539014 2539014 2400609 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 26749488 NS recurrent 57 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879491 1879491 1769993 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1522947 1522947 1445319 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 60 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 V141 1179746 1091708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 76 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 ABC-1 946050 862576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891313 1891313 1780682 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226917 2226917 2094652 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1042914 1042914 959255 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1517070 1517070 1439664 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 47 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2422803 2422803 2285725 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1468085 1468085 1391931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 93 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2105834 2105834 1983872 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1196036 1196036 1107931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 19272767 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2429761 2429761 2292665 lung right NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26400668 surgery - NOS metastasis 76 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481226 1481226 1404855 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469791 1469791 1393530 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2566149 2566149 2427540 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 27801981 surgery - NOS metastasis 74 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1908804 1908804 1797325 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23507602 fine needle aspirate metastasis 68 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027780 2027780 1909683 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032265 2032265 1913736 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 fine needle aspirate recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481233 1481233 1404862 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302270 1302270 1213321 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2009147 2009147 1891881 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1558205 1558205 1479576 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21835826 surgery - NOS metastasis 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1075910 1075910 991164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103807 1103807 1018059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2539014 2539014 2400609 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 132563575 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Reported in another cancer sample as somatic 26749488 NS recurrent 57 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2255G>C 7:g.55181399G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895110 1895110 1783802 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 907087 907087 824599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453425 1453425 1377458 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891338 1891338 1780707 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899304 899304 816916 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920154 920154 837234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 49 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625559 2625559 2485971 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 51 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899311 899311 816923 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453424 1453424 1377457 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668458 1668458 1581751 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891177 1891177 1780546 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089141 1089141 1004095 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1077338 1077338 992592 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1547773 1547773 1469895 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed metastasis 58 ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453435 1453435 1377468 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00004T00004 2857337 2712637 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 109594 2812900 2669314 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 66 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1465899 1465899 1389746 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 77 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 INV147 2514387 2376750 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 26968814 surgery-fixed primary ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1014117 1014117 931291 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046002 2046002 1926297 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336415 1336415 1246800 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20430469 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468884 1468884 1392623 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21128242 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965922 1965922 1852415 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095923 2095923 1973987 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1465900 1465900 1389747 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228767 2228767 2096479 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24956168 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1517891 1517891 1440269 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21572125 fine needle aspirate NS 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 HCC4011-GR-step 1896432 1785120 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23542356 cell-line NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862936 2862936 2718098 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26682906 surgery-fixed recurrent 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173385 1173385 1085469 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838642 1838642 1732743 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618795 1618795 1537547 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 46 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2209393 2209393 2077626 lung NS NS NS carcinoma signet_ring_cell_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25007143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637105 1637105 1553153 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1909763 1909763 1798280 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23559152 surgery-fixed NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587288 1587288 1508459 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218539 2218539 2086550 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656102 1656102 1570759 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21311943 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345588 2345588 2210260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237684 1237684 1149431 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637186 1637186 1553234 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965839 1965839 1852332 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770675 1770675 1674915 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264093 2264093 2131077 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1024779 1024779 941756 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17020982 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095913 2095913 1973977 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179656 1179656 1091618 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422803 2422803 2285725 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264140 2264140 2131124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676415 1676415 1589183 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468085 1468085 1391931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 93 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1530998 1530998 1453370 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179115 1179115 1091077 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19185949 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469405 1469405 1393144 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2007091 2007091 1889972 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23790173 surgery-fixed NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2033586 2033586 1915035 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24137397 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1154574 1154574 1066910 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18946755 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045981 2045981 1926276 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2733227 2733227 2591980 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 132548259 c.1652C>T p.P551L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 61 ENSP00000395243.3:p.Pro551Leu ENST00000454757.6:c.1652C>T 7:g.55165344C>T EGFR ENST00000275493.6 3633 3236 2346474 2346474 2211137 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425757 2425757 2288678 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246662 1246662 1158341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474442 2474442 2337211 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1435657 1435657 1344936 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20661086 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1424055 1424055 1334083 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20595147 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1585371 1585371 1506692 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22011666 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2909926 2909926 2764062 breast NS NS NS carcinoma metaplastic_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 33942253 surgery-fixed NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469447 1469447 1393186 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637148 1637148 1553196 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045990 2045990 1926285 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878860 2878860 2733375 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27368130 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226150 2226150 2093885 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476887 2476887 2339656 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336841 1336841 1247226 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551537 1551537 1473642 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142109 2142109 2011327 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 E8 1303894 1214945 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20036793 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964318 1964318 1850853 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264100 2264100 2131084 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422782 2422782 2285704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345382 2345382 2210054 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096163 2096163 1974227 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081934 2081934 1960356 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24440279 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230457 1230457 1142271 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205981 2205981 2074214 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1512589 1512589 1435273 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21508367 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1135553 1135553 1048117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18676761 NS NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2142095 2142095 2011313 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 48 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914922 1914922 1802924 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964319 1964319 1850854 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000260 2000260 1885158 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027780 2027780 1909683 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444746 1444746 1368989 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1516981 1516981 1439575 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21598249 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965864 1965864 1852357 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874739 1874739 1765330 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986228 1986228 1872464 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1543084 1543084 1465279 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21791641 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705472 1705472 1613378 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625598 2625598 2486010 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 44 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1162982 1162982 1075305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18992959 NS recurrent 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777339 1777339 1681342 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522881 1522881 1445253 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120939 1120939 1034095 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1201400 1201400 1113290 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19357847 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1029020 1029020 945891 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17075123 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637234 1637234 1553282 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246706 1246706 1158385 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964338 1964338 1850873 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 19 2570191 2431488 skin face NS NS adnexal_tumour other sebaceoma NS n COSV51794784 COSM13182 132548944 c.2068G>A p.G690S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 71 ENSP00000395243.3:p.Gly690Ser ENST00000454757.6:c.2068G>A 7:g.55174740G>A EGFR ENST00000275493.6 3633 3236 2908039 2908039 2762219 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24457237 surgery-fixed NS 62 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1148665 1148665 1061106 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 18829487 surgery-fixed NS 81 ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-02-0046-01 1910140 1798431 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 61 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1523074 1523074 1445446 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 41 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2156367 2156367 2025375 lung left_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 24752053 surgery - NOS metastasis 70 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879495 1879495 1769997 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2659794 2659794 2519952 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876039 2876039 2730554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876039 2876039 2730554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 66 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MG-198-tumor 2819083 2675382 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1875359 1875359 1765942 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1453492 1453492 1377525 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1136874 1136874 1049438 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983763 1983763 1869999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593018 1593018 1513944 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1738958 1738958 1644789 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594599 1594599 1515567 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00178T00178 2857362 2712662 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 19 2570191 2431488 skin face NS NS adnexal_tumour other sebaceoma NS n COSV51771864 COSM6226 132555722 c.2191C>T p.R731C Substitution - Missense 38 7:55181335-55181335 + - PATHOGENIC .97187 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 71 ENSP00000395243.3:p.Arg731Cys ENST00000454757.6:c.2191C>T 7:g.55181335C>T EGFR ENST00000275493.6 3633 3236 1029330 1029330 946201 upper_aerodigestive_tract pharynx oropharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51789362 COSM13184 99406147 c.2236G>A p.E746K Substitution - Missense 38 7:55174773-55174773 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 17121883 surgery-fixed NS ENSP00000275493.2:p.Glu746Lys ENST00000275493.6:c.2236G>A 7:g.55174773G>A EGFR ENST00000275493.6 3633 3236 S001108 1027693 944669 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 17177598 cell-line NS ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1484300 1484300 1407926 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51778659 COSM14070 132547729 c.2453G>A p.G818D Substitution - Missense 38 7:55191837-55191837 + - PATHOGENIC .92688 Reported in another cancer sample as somatic 21266046 surgery-fixed primary 66 ENSP00000395243.3:p.Gly818Asp ENST00000454757.6:c.2453G>A 7:g.55191837G>A EGFR ENST00000275493.6 3633 3236 1165596 1165596 1077910 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Reported in another cancer sample as somatic 19050706 surgery fresh/frozen NS ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 015 2640419 2500721 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 27545006 fixed - NOS NS 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879546 1879546 1770048 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879519 1879519 1770021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2734338 2734338 2593065 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 29731638 surgery - NOS NS 52 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1895066 1895066 1783758 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2239182 2239182 2106714 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 25130612 fine needle aspirate NS 48 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PF08 2560049 2421473 large_intestine colon sigmoid NS adenoma tubular NS NS n COSV51779162 COSM21689 132548259 c.1652C>T p.P551L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 27609830 surgery-fixed NS ENSP00000395243.3:p.Pro551Leu ENST00000454757.6:c.1652C>T 7:g.55165344C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166430 1166430 1078744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773206 COSM28603 132560955 c.2158G>A p.V720M Substitution - Missense het 38 7:55181302-55181302 + - PATHOGENIC .97963 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 51 ENSP00000395243.3:p.Val720Met ENST00000454757.6:c.2158G>A 7:g.55181302G>A EGFR ENST00000275493.6 3633 3236 T155 1861137 1752078 endometrium NS NS NS carcinoma serous_carcinoma NS NS y COSV51785413 COSM1176673 99382805 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 23104009 surgery fresh/frozen primary ENSP00000275493.2:p.Arg252His ENST00000275493.6:c.755G>A 7:g.55154018G>A EGFR ENST00000275493.6 3633 3236 2078488 2078488 1957207 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2402490 2402490 2265346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 84 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2665664 2665664 2525373 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28978102 surgery - NOS recurrent 51 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1585352 1585352 1506673 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22011666 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1547778 1547778 1469900 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1493345 1493345 1416335 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2028999 2028999 1910881 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336834 1336834 1247219 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2361980 2361980 2224923 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25726043 NS NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246693 1246693 1158372 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226170 2226170 2093905 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425745 2425745 2288666 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1047977 1047977 964205 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17337084 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 916970 916970 834351 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16052537 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228764 2228764 2096476 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24956168 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025398 2025398 1907487 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402490 2402490 2265346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 84 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046620 2046620 1926914 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656134 1656134 1570791 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21311943 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025400 2025400 1907489 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770606 1770606 1674846 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1165596 1165596 1077910 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19050706 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475406 1475406 1399105 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2076959 2076959 1955708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24369725 surgery-fixed NS 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469458 1469458 1393197 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2141436 2141436 2010654 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24636848 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1465899 1465899 1389746 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637068 1637068 1553116 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637144 1637144 1553192 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637690 2637690 2498063 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 circulating tumour recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027807 2027807 1909710 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264294 2264294 2131278 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2840787 2840787 2696347 prostate NS NS NS carcinoma NS NS NS n COSV51785413 COSM1176673 133211383 c.620G>A p.R207H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000415559.1:p.Arg207His ENST00000455089.5:c.620G>A 7:g.55154018G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2757125 2757125 2615768 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 132549057 c.2183A>T p.H728L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 29858019 circulating tumour recurrent 50 ENSP00000395243.3:p.His728Leu ENST00000454757.6:c.2183A>T 7:g.55181327A>T EGFR ENST00000275493.6 3633 3236 1102396 1102396 1016648 lung right_upper_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18208799 surgery-fixed primary 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422910 2422910 2285832 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096060 2096060 1974124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844329 1844329 1737363 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770641 1770641 1674881 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476873 2476873 2339642 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1110735 1110735 1024613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18325048 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345597 2345597 2210269 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549154 2549154 2410609 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083073 1083073 998238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17685931 surgery-fixed NS 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095896 2095896 1973960 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2486038 2486038 2348687 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27013585 surgery - NOS primary 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228739 2228739 2096451 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24956168 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264205 2264205 2131189 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106548 2106548 1984411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637096 1637096 1553144 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887375 1887375 1777047 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2437325 2437325 2300175 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23211219 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1223891 1223891 1135723 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19517135 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2132032 2132032 2006095 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24429877 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770709 1770709 1674949 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1668662 1668662 1581954 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22523351 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986152 1986152 1872388 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444719 1444719 1368962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1661842 1661842 1575455 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22487432 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106561 2106561 1984424 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638751 1638751 1554750 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096074 2096074 1974138 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1107786 1107786 1021689 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2008790 2008790 1891524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770589 1770589 1674829 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937535 1937535 1824469 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228288 2228288 2096012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2440995 2440995 2303834 lung left_upper_lobe NS NS carcinoma adenocarcinoma transformed_to_small_cell_carcinoma NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26557922 surgery - NOS NS 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163042 2163042 2031626 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083471 2083471 1961754 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481316 surgery - NOS primary 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1312887 1312887 1223796 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19884861 blood-bone marrow NS 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656987 1656987 1571642 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22338650 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096002 2096002 1974066 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2894940 2894940 2749421 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS primary 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1112948 1112948 1026459 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448997 surgery-fixed NS 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1435655 1435655 1344934 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20661086 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862176 2862176 2717378 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51862598 COSM6938266 132547606 c.1889G>A p.R630Q Substitution - Missense 38 7:55173087-55173087 + - PATHOGENIC .98305 Confirmed somatic variant 27873319 surgery fresh/frozen NS 77 ENSP00000395243.3:p.Arg630Gln ENST00000454757.6:c.1889G>A 7:g.55173087G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LUAD-NYU1093 1765123 1669443 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 61 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1730102 1730102 1636073 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22753836 fine needle aspirate NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1551567 1551567 1473672 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2555799 2555799 2417236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 26599269 surgery - NOS NS 58 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2770723 2770723 2628924 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25403583 surgery-fixed NS 62 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2264439 2264439 2131423 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2000268 2000268 1885166 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2757125 2757125 2615768 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 133203995 c.2183A>T p.H728L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 29858019 circulating tumour recurrent 50 ENSP00000415559.1:p.His728Leu ENST00000455089.5:c.2183A>T 7:g.55181327A>T EGFR ENST00000275493.6 3633 3236 1479953 1479953 1403613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767182 COSM27110 99381953 c.2356G>A p.V786M Substitution - Missense 38 7:55181365-55181365 + - PATHOGENIC .97319 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Val786Met ENST00000275493.6:c.2356G>A 7:g.55181365G>A EGFR ENST00000275493.6 3633 3236 2136625 2136625 2006176 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1014081 1014081 931255 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CT35 1063207 979252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 75 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1534885 1534885 1457220 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSM97027 178382712 c.? p.L858M Substitution - Missense + - Reported in another cancer sample as somatic 21718596 surgery-fixed NS ENSP00000275493.2:p.Leu858Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1992091 1992091 1877408 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 59 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1891338 1891338 1780707 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 106 898382 815994 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1194731 1194731 1106626 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098982 1098982 1013574 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51768262 COSM26445 133205089 c.2165C>T p.A722V Substitution - Missense het 38 7:55181309-55181309 + - PATHOGENIC .97799 Reported in another cancer sample as somatic 18199332 surgery-fixed primary ENSP00000415559.1:p.Ala722Val ENST00000455089.5:c.2165C>T 7:g.55181309C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1075910 1075910 991164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 24 897185 814808 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-12-0829-01 2178136 2046434 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772147 COSM375343 99393933 c.1934C>G p.S645C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Confirmed somatic variant 329 NS NS 75 ENSP00000275493.2:p.Ser645Cys ENST00000275493.6:c.1934C>G 7:g.55172997C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2778634 2778634 2636688 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS n COSV51859563 COSM6910210 132549516 c.2374G>A p.D792N Substitution - Missense 38 7:55191758-55191758 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000395243.3:p.Asp792Asn ENST00000454757.6:c.2374G>A 7:g.55191758G>A EGFR ENST00000275493.6 3633 3236 2239187 2239187 2106719 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 48 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897830 897830 815452 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1242317 1242317 1154047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777111 COSM33725 99387470 c.2609A>G p.H870R Substitution - Missense hom 38 7:55191858-55191858 + - PATHOGENIC .97748 Reported in another cancer sample as somatic 19671738 surgery - NOS metastasis 56 ENSP00000275493.2:p.His870Arg ENST00000275493.6:c.2609A>G 7:g.55191858A>G EGFR ENST00000275493.6 3633 3236 1469946 1469946 1393685 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 20522446 surgery-fixed NS 81 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1891312 1891312 1780681 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2732918 2732918 2591671 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 39 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1891317 1891317 1780686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043130 1043130 959471 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51778659 COSM14070 133202857 c.2453G>A p.G818D Substitution - Missense 38 7:55191837-55191837 + - PATHOGENIC .92688 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 51 ENSP00000415559.1:p.Gly818Asp ENST00000455089.5:c.2453G>A 7:g.55191837G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043128 1043128 959469 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51782403 COSM22951 132581124 c.2249T>C p.F750S Substitution - Missense 38 7:55181393-55181393 + - .67484 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 76 ENSP00000395243.3:p.Phe750Ser ENST00000454757.6:c.2249T>C 7:g.55181393T>C EGFR ENST00000275493.6 3633 3236 1075005 1075005 990259 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1592987 1592987 1513913 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1031900 1031900 948691 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17085664 NS recurrent ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1231316 1231316 1143106 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19530244 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1043860 1043860 960201 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891243 1891243 1780612 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450930 1450930 1375073 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 51 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136868 1136868 1049432 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1931643 1931643 1818933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2566146 2566146 2427537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 27794398 surgery-fixed NS 74 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2422465 2422465 2285387 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25521406 surgery - NOS metastasis 56 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1991298 1991298 1876633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891242 1891242 1780611 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 IR3T 897723 815346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15118125 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LUAD_E01419 1765148 1669468 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 51 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2239177 2239177 2106709 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 56 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875377 1875377 1765960 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2009162 2009162 1891896 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891238 1891238 1780607 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1434021 1434021 1343436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1103805 1103805 1018057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593027 1593027 1513953 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1931647 1931647 1818937 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2778769 2778769 2636823 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 29066915 NS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879567 1879567 1770069 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 IIIA 1179821 1091783 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 19181917 surgery-fixed metastasis 27 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1042898 1042898 959239 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773049 COSM22943 99376120 c.2543C>T p.P848L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Pro848Leu ENST00000275493.6:c.2543C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 MTC34 2546185 2407665 thyroid NS NS NS carcinoma NS NS NS n COSV51773049 COSM22943 99376120 c.2543C>T p.P848L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Reported in another cancer sample as somatic 26294908 surgery - NOS NS ENSP00000275493.2:p.Pro848Leu ENST00000275493.6:c.2543C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 1974001 1974001 1860243 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51818388 COSM53104 99406297 c.2390G>A p.C797Y Substitution - Missense 38 7:55181399-55181399 + - PATHOGENIC .98244 Reported in another cancer sample as somatic 23584298 surgery - NOS NS ENSP00000275493.2:p.Cys797Tyr ENST00000275493.6:c.2390G>A 7:g.55181399G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2778634 2778634 2636688 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS n COSV51859563 COSM6910210 133204470 c.2374G>A p.D792N Substitution - Missense 38 7:55191758-55191758 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000415559.1:p.Asp792Asn ENST00000455089.5:c.2374G>A 7:g.55191758G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625552 2625552 2485964 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862717 2862717 2717880 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897831 897831 815453 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1884153 1884153 1774040 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1075923 1075923 991177 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2476830 2476830 2339599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032211 2032211 1913682 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032210 2032210 1913681 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1246724 1246724 1158403 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1542300 1542300 1464603 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081898 2081898 1960320 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2906649 2906649 2760900 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29616327 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469789 1469789 1393528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2476828 2476828 2339597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081899 2081899 1960321 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 898242 898242 815854 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 15728811 surgery-fixed recurrent 73 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1103805 1103805 1018057 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110460 1110460 1024338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1751707 1751707 1656523 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899315 899315 816927 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1202561 1202561 1114447 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1110467 1110467 1024345 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897835 897835 815457 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891254 1891254 1780623 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1500588 1500588 1423467 stomach NS NS NS carcinoma mucinous_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21436633 surgery - NOS NS 76 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450849 1450849 1374992 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067067 1067067 983047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875371 1875371 1765954 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1479934 1479934 1403594 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1714997 1714997 1622576 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22710815 surgery-fixed primary 77 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2566146 2566146 2427537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 27794398 surgery-fixed NS 74 ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226875 2226875 2094610 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1547773 1547773 1469895 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed metastasis 58 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1882220 1882220 1772371 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23392229 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2000193 2000193 1885091 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2078483 2078483 1957202 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444745 1444745 1368988 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535035 1535035 1457370 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1648545 1648545 1563500 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226900 2226900 2094635 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1305391 1305391 1216439 lung NS NS NS carcinoma oncocytic_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20023269 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453498 1453498 1377531 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1981033 1981033 1867269 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983746 1983746 1869982 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-18-K32111 2905107 2759363 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1990903 1990903 1876238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S25 1063224 979269 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1162981 1162981 1075304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18992959 NS recurrent 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770513 1770513 1674753 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875693 1875693 1766276 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2136675 2136675 2006226 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777404 1777404 1681407 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096039 2096039 1974103 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475383 1475383 1399082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777213 1777213 1681216 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046054 2046054 1926349 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264202 2264202 2131186 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105812 2105812 1983850 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279042 1279042 1190338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed primary 44 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230477 1230477 1142291 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141320 1141320 1053768 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937553 1937553 1824487 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475464 1475464 1399163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096155 2096155 1974219 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095980 2095980 1974044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474449 2474449 2337218 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965866 1965866 1852359 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025385 2025385 1907474 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345468 2345468 2210140 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173386 1173386 1085470 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638762 1638762 1554761 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914952 1914952 1802954 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336837 1336837 1247222 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336867 1336867 1247252 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20423982 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637192 1637192 1553240 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474445 2474445 2337214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459512 1459512 1383455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081898 2081898 1960320 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279087 1279087 1190383 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed metastasis 50 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2562091 2562091 2423487 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965840 1965840 1852333 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515235 1515235 1437845 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1445179 1445179 1369422 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20682976 surgery - NOS primary 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2136625 2136625 2006176 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937519 1937519 1824453 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551562 1551562 1473667 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1086838 1086838 1001859 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17848912 blood-bone marrow NS 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421218 2421218 2284140 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205968 2205968 2074201 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2372825 2372825 2235618 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25904052 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346532 2346532 2211195 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1625785 1625785 1543009 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983745 1983745 1869981 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302287 1302287 1213338 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226866 2226866 2094601 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2396138 2396138 2258969 lung left_bronchus NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24942894 fine needle aspirate primary 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1625784 1625784 1543008 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1517067 1517067 1439661 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 59 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-17-X19682 2905664 2759920 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51824002 COSM6937752 132572106 c.2659C>T p.R887C Substitution - Missense 38 7:55198809-55198809 + - PATHOGENIC .91422 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000395243.3:p.Arg887Cys ENST00000454757.6:c.2659C>T 7:g.55198809C>T EGFR ENST00000275493.6 3633 3236 1707032 1707032 1614938 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22695392 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422931 2422931 2285853 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345388 2345388 2210060 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2562085 2562085 2423481 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23619604 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1610950 1610950 1530178 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22157369 surgery-fixed metastasis 41 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083351 1083351 998516 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17596643 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2486052 2486052 2348701 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27013585 surgery - NOS primary 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2157008 2157008 2025983 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469342 1469342 1393081 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430047 1430047 1339465 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965905 1965905 1852398 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264304 2264304 2131288 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444730 1444730 1368973 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637238 1637238 1553286 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1102392 1102392 1016644 lung left_lower_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18208799 surgery-fixed primary 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1997147 1997147 1882356 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23930206 fixed - NOS metastasis 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1516778 1516778 1439372 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21575212 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000168 2000168 1885066 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637077 1637077 1553125 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1812621 1812621 1711955 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23174717 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838647 1838647 1732748 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731706 1731706 1637672 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22806307 NS NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1707034 1707034 1614940 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22695392 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096125 2096125 1974189 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2067302 2067302 1947099 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23783797 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444790 1444790 1369033 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842991 1842991 1736239 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203088 2203088 2071346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667698 1667698 1580991 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240671 2240671 2108202 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1610415 1610415 1529655 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22142557 pleural effusion NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081899 2081899 1960321 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705483 1705483 1613389 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637251 1637251 1553299 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921896 1921896 1809214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2241823 2241823 2109354 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25228365 NS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345535 2345535 2210207 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179112 1179112 1091074 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19185949 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618882 1618882 1537634 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444780 1444780 1369023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2733227 2733227 2591980 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 99374883 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 61 ENSP00000275493.2:p.Pro596Leu ENST00000275493.6:c.1787C>T 7:g.55165344C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-18-T40375 2905680 2759936 NS NS NS NS malignant_melanoma NS NS NS n COSV51830943 COSM3639753 132581709 c.2629G>A p.E877K Substitution - Missense 38 7:55198779-55198779 + - PATHOGENIC .98622 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Glu877Lys ENST00000454757.6:c.2629G>A 7:g.55198779G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625552 2625552 2485964 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2732923 2732923 2591676 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 64 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2757125 2757125 2615768 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 29858019 circulating tumour recurrent 50 ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625552 2625552 2485964 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 19 2570191 2431488 skin face NS NS adnexal_tumour other sebaceoma NS n COSV51771864 COSM6226 133211629 c.2191C>T p.R731C Substitution - Missense 38 7:55181335-55181335 + - PATHOGENIC .97187 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 71 ENSP00000415559.1:p.Arg731Cys ENST00000455089.5:c.2191C>T 7:g.55181335C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CT35 1063207 979252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 75 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1202560 1202560 1114446 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1429296 1429296 1338747 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2156365 2156365 2025374 lung left_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24752053 surgery - NOS primary 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1453492 1453492 1377525 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1047001 1047001 963232 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1860431 1860431 1751372 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1738958 1738958 1644789 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593018 1593018 1513944 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920131 920131 837211 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136891 1136891 1049455 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1302276 1302276 1213327 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 MG-196-tumor 2819081 2675380 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899305 899305 816917 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1593019 1593019 1513945 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1450865 1450865 1375008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 77 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226906 2226906 2094641 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1875359 1875359 1765942 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1136874 1136874 1049438 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594599 1594599 1515567 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 899341 899341 816953 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166444 1166444 1078758 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659809 2659809 2519967 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983763 1983763 1869999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897781 897781 815403 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1592992 1592992 1513918 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1996546 1996546 1881755 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 23922984 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098982 1098982 1013574 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51768262 COSM26445 132550179 c.2165C>T p.A722V Substitution - Missense het 38 7:55181309-55181309 + - PATHOGENIC .97799 Reported in another cancer sample as somatic 18199332 surgery-fixed primary ENSP00000395243.3:p.Ala722Val ENST00000454757.6:c.2165C>T 7:g.55181309C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CSCC-40-T 2292477 2158541 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51858853 COSM4512041 133259303 c.754C>T p.R252C Substitution - Missense het 38 7:55154152-55154152 + - PATHOGENIC .97012 Confirmed somatic variant 25303977 surgery fresh/frozen metastasis 49 ENSP00000415559.1:p.Arg252Cys ENST00000455089.5:c.754C>T 7:g.55154152C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2156367 2156367 2025375 lung left_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 24752053 surgery - NOS metastasis 70 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1523074 1523074 1445446 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 41 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2659794 2659794 2519952 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879495 1879495 1769997 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BL-18-T40375 2905680 2759936 NS NS NS NS malignant_melanoma NS NS NS n COSV51816692 COSM6503372 132575469 c.2905G>A p.D969N Substitution - Missense 38 7:55201281-55201281 + - PATHOGENIC .99528 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000395243.3:p.Asp969Asn ENST00000454757.6:c.2905G>A 7:g.55201281G>A EGFR ENST00000275493.6 3633 3236 897283 897283 814906 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15118073 surgery fresh/frozen primary 32 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732934 2732934 2591687 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 72 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-50-6595-01 1780173 1684172 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 74 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 19 2570191 2431488 skin face NS NS adnexal_tumour other sebaceoma NS n COSV51794784 COSM13182 133203905 c.2068G>A p.G690S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 71 ENSP00000415559.1:p.Gly690Ser ENST00000455089.5:c.2068G>A 7:g.55174740G>A EGFR ENST00000275493.6 3633 3236 2555799 2555799 2417236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 26599269 surgery - NOS NS 58 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1479943 1479943 1403603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1522944 1522944 1445316 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 63 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1816946 1816946 1716114 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2027352 2027352 1909420 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 24055406 surgery-fixed NS 58 ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1895066 1895066 1783758 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 2772829 2772829 2631011 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 29594878 surgery - NOS NS 89 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DU-7012-01 2194261 2062539 central_nervous_system brain NS NS glioma NS NS NS y COSV51774829 COSM1451549 133204902 c.632A>G p.D211G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 545 NS NS 74 ENSP00000415559.1:p.Asp211Gly ENST00000455089.5:c.632A>G 7:g.55154030A>G EGFR ENST00000275493.6 3633 3236 2591479 2591479 2452439 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591479 2591479 2452439 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103796 1103796 1018048 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2819294 2819294 2675593 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 30711944 surgery - NOS NS 63 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1576791 1576791 1498232 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 56 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1024766 1024766 941743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 pleural effusion recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2819306 2819306 2675605 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 30711944 surgery - NOS recurrent 79 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1992094 1992094 1877411 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow NS 75 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2819289 2819289 2675588 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 30711944 pleural effusion recurrent 66 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879489 1879489 1769991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625552 2625552 2485964 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CSCC-40-T 2292477 2158541 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51858853 COSM4512041 132596020 c.754C>T p.R252C Substitution - Missense het 38 7:55154152-55154152 + - PATHOGENIC .97012 Confirmed somatic variant 25303977 surgery fresh/frozen metastasis 49 ENSP00000395243.3:p.Arg252Cys ENST00000454757.6:c.754C>T 7:g.55154152C>T EGFR ENST00000275493.6 3633 3236 1162206 1162206 1074538 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766880 COSM28516 99392483 c.2404G>T p.V802F Substitution - Missense 38 7:55181413-55181413 + - PATHOGENIC .89385 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000275493.2:p.Val802Phe ENST00000275493.6:c.2404G>T 7:g.55181413G>T EGFR ENST00000275493.6 3633 3236 1668436 1668436 1581729 lung bronchus NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22526156 surgery-fixed primary 18 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A017-T-S20 2757378 2615994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 56 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1075910 1075910 991164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1992091 1992091 1877408 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 59 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1891338 1891338 1780707 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043130 1043130 959471 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51778659 COSM14070 132547729 c.2453G>A p.G818D Substitution - Missense 38 7:55191837-55191837 + - PATHOGENIC .92688 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 51 ENSP00000395243.3:p.Gly818Asp ENST00000454757.6:c.2453G>A 7:g.55191837G>A EGFR ENST00000275493.6 3633 3236 1098814 1098814 1013406 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767386 COSM18423 99393803 c.2500G>T p.V834L Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .9903 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 57 ENSP00000275493.2:p.Val834Leu ENST00000275493.6:c.2500G>T 7:g.55191749G>T EGFR ENST00000275493.6 3633 3236 2841857 2841857 2697406 soft_tissue fibrous_tissue_and_uncertain_origin trunk NS desmoid_tumour-fibromatosis NS NS NS n COSV51777833 COSM4680394 99383629 c.1580G>A p.R527Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Reported in another cancer sample as somatic 32099073 surgery-fixed NS 27 ENSP00000275493.2:p.Arg527Gln ENST00000275493.6:c.1580G>A 7:g.55161580G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1593027 1593027 1513953 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1931647 1931647 1818937 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2585421 2585421 2446585 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576891 COSM9396331 133217776 c.1265A>C p.K422T Substitution - Missense het 38 7:55160240-55160240 + - NEUTRAL .10442 Reported in another cancer sample as somatic 25623215 surgery - NOS recurrent ENSP00000415559.1:p.Lys422Thr ENST00000455089.5:c.1265A>C 7:g.55160240A>C EGFR ENST00000275493.6 3633 3236 1592998 1592998 1513924 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895143 1895143 1783835 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895105 1895105 1783797 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862708 2862708 2717871 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2009152 2009152 1891886 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862719 2862719 2717882 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2277204 2277204 2143736 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25328676 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1627725 1627725 1544637 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891181 1891181 1780550 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895130 1895130 1783822 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2372586 2372586 2235379 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895166 1895166 1783858 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1074879 1074879 990133 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17505415 surgery fresh/frozen primary 71 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 907089 907089 824601 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2625560 2625560 2485972 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 51 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2659800 2659800 2519958 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302268 1302268 1213319 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1103629 1103629 1017881 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18258923 surgery-fixed NS 53 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1981019 1981019 1867255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302285 1302285 1213336 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042908 1042908 959249 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2840305 2840305 2695865 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31632838 surgery - NOS NS 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875352 1875352 1765935 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1705531 1705531 1613437 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2096225 2096225 1974289 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1667725 1667725 1581018 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345112 2345112 2209784 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345060 2345060 2209732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1246742 1246742 1158421 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2096229 2096229 1974293 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000165-T01-IM3 2714735 2573556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD_06 2688647 2547629 skin face NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51852113 COSM4501266 132563348 c.449C>T p.P150L Substitution - Missense het 38 7:55151318-55151318 + - NEUTRAL .31382 Confirmed somatic variant 24662767 surgery fresh/frozen NS 75 ENSP00000395243.3:p.Pro150Leu ENST00000454757.6:c.449C>T 7:g.55151318C>T EGFR ENST00000275493.6 3633 3236 1895128 1895128 1783820 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895084 1895084 1783776 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1110465 1110465 1024343 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1990912 1990912 1876247 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1295380 1295380 1206459 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19881244 surgery-fixed NS 90 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2239178 2239178 2106710 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 surgery - NOS NS 53 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1575150 1575150 1496591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21986139 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1594601 1594601 1515569 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2625558 2625558 2485970 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1098866 1098866 1013458 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1310473 1310473 1221418 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20061937 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1610921 1610921 1530149 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22157931 surgery-fixed primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1434017 1434017 1343432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1549818 1549818 1471923 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1592989 1592989 1513915 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983765 1983765 1870001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 Sq-1 946075 862601 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DCR9 1690658 1598935 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 132560744 c.1341C>A p.S447R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000395243.3:p.Ser447Arg ENST00000454757.6:c.1341C>A 7:g.55160316C>A EGFR ENST00000275493.6 3633 3236 BL-17-A52771 2905636 2759892 NS NS NS NS malignant_melanoma NS NS NS n COSV51792018 COSM4992972 99378183 c.3134C>T p.S1045F Substitution - Missense 38 7:55201754-55201754 + - PATHOGENIC .97067 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Ser1045Phe ENST00000275493.6:c.3134C>T 7:g.55201754C>T EGFR ENST00000275493.6 3633 3236 1042861 1042861 959202 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002296-T01-IM3 2782972 2640755 prostate NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51800946 COSM6921640 133212767 c.2144T>C p.L715P Substitution - Missense het 38 7:55174816-55174816 + - PATHOGENIC .99068 Confirmed somatic variant 28825054 surgery-fixed metastasis 55 ENSP00000415559.1:p.Leu715Pro ENST00000455089.5:c.2144T>C 7:g.55174816T>C EGFR ENST00000275493.6 3633 3236 1479943 1479943 1403603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1513416 1513416 1436077 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21497370 fixed - NOS metastasis ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1992086 1992086 1877403 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 50 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1024776 1024776 941753 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1090038 1090038 1004985 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17945377 surgery - NOS primary 32 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891219 1891219 1780588 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1981023 1981023 1867259 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1237594 1237594 1149341 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 TCGA-02-0046-01 1910140 1798431 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 61 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 2471720 2471720 2334491 lung right NS NS carcinoma adenocarcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Reported in another cancer sample as somatic 26845121 surgery - NOS metastasis 59 ENSP00000275493.2:p.Leu861Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD_06 2688647 2547629 skin face NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51852113 COSM4501266 133219599 c.449C>T p.P150L Substitution - Missense het 38 7:55151318-55151318 + - NEUTRAL .31382 Confirmed somatic variant 24662767 surgery fresh/frozen NS 75 ENSP00000415559.1:p.Pro150Leu ENST00000455089.5:c.449C>T 7:g.55151318C>T EGFR ENST00000275493.6 3633 3236 1879577 1879577 1770079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2432376 2432376 2295279 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 26473643 surgery fresh/frozen metastasis 53 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1891329 1891329 1780698 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1083324 1083324 998489 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM23613 178378830 c.? p.G719D Substitution - Missense + - Reported in another cancer sample as somatic 17596643 surgery-fixed NS ENSP00000275493.2:p.Gly719Asp EGFR ENST00000275493.6 3633 3236 2732912 2732912 2591665 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 99377226 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 60 ENSP00000275493.2:p.Ala289Asp ENST00000275493.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732925 2732925 2591678 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 75 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 1891300 1891300 1780669 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2225976 2225976 2093711 lung NS NS NS carcinoma NS NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24924582 fine needle aspirate NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2205989 2205989 2074222 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1909762 1909762 1798279 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23559152 surgery-fixed NS 44 ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2841814 2841814 2697363 soft_tissue fibrous_tissue_and_uncertain_origin abdomen NS desmoid_tumour-fibromatosis NS NS NS n COSV99290440 COSM7410173 99418403 c.3173G>A p.C1058Y Substitution - Missense 38 7:55202527-55202527 + - NEUTRAL .29295 Reported in another cancer sample as somatic 32099073 surgery-fixed NS 27 ENSP00000275493.2:p.Cys1058Tyr ENST00000275493.6:c.3173G>A 7:g.55202527G>A EGFR ENST00000275493.6 3633 3236 P-0001303-T01-IM3 2717027 2575848 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51807743 COSM133179 99396505 c.2065G>A p.V689M Substitution - Missense het 38 7:55173924-55173924 + - PATHOGENIC .9843 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Val689Met ENST00000275493.6:c.2065G>A 7:g.55173924G>A EGFR ENST00000275493.6 3633 3236 P-0001303-T01-IM3 2717027 2575848 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1746665 1746665 1651641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2476844 2476844 2339613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1031895 1031895 948686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 17085664 NS metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2664329 2664329 2524407 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 32 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2429764 2429764 2292667 lung right NS NS carcinoma adenocarcinoma transformed_to_small_cell_carcinoma NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26400668 surgery - NOS metastasis 76 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2485111 2485111 2347811 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 20630828 NS recurrent 73 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2664333 2664333 2524409 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 63 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2426856 2426856 2289777 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746448 1746448 1651424 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22895145 NS recurrent 48 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1542238 1542238 1464541 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21784628 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2824351 2824351 2680160 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 31543779 surgery - NOS recurrent 60 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2665668 2665668 2525377 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28978102 pleural effusion recurrent 54 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2665660 2665660 2525369 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28978102 surgery - NOS metastasis 72 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469783 1469783 1393522 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422836 2422836 2285758 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2027740 2027740 1909643 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 P-0004718-T01-IM5 2721121 2579942 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 4990 915974 833373 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51802602 COSM13181 132564438 c.2063C>T p.P688L Substitution - Missense 38 7:55174735-55174735 + - PATHOGENIC .99806 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000395243.3:p.Pro688Leu ENST00000454757.6:c.2063C>T 7:g.55174735C>T EGFR ENST00000275493.6 3633 3236 2525697 2525697 2387886 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2548696 2548696 2410151 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27580550 surgery - NOS metastasis 65 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469861 1469861 1393600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1246727 1246727 1158406 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1467315 1467315 1391161 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 20940188 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1246732 1246732 1158411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2153194 2153194 2022204 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2664360 2664360 2524422 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 57 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032215 2032215 1913686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2686024 2686024 2545059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2476872 2476872 2339641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2422839 2422839 2285761 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2906655 2906655 2760906 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29616327 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DU-7012-01 2194261 2062539 central_nervous_system brain NS NS glioma NS NS NS y COSV51774829 COSM1451549 132549970 c.632A>G p.D211G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 545 NS NS 74 ENSP00000395243.3:p.Asp211Gly ENST00000454757.6:c.632A>G 7:g.55154030A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2732923 2732923 2591676 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 64 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103796 1103796 1018048 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1567512 1567512 1489144 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21949883 fine needle aspirate metastasis ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1522944 1522944 1445316 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 63 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1816946 1816946 1716114 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1996546 1996546 1881755 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23922984 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1705531 1705531 1613437 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1618057 1618057 1536853 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000264 2000264 1885162 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163051 2163051 2031635 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2585421 2585421 2446585 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576891 COSM9396331 132561609 c.1265A>C p.K422T Substitution - Missense het 38 7:55160240-55160240 + - NEUTRAL .10442 Reported in another cancer sample as somatic 25623215 surgery - NOS recurrent ENSP00000395243.3:p.Lys422Thr ENST00000454757.6:c.1265A>C 7:g.55160240A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A017-T-S20 2757378 2615994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 56 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1696872 1696872 1605000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22674612 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179661 1179661 1091623 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1498650 1498650 1421528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21315472 surgery - NOS metastasis 85 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1896947 1896947 1785634 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23542356 surgery-fixed recurrent 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046007 2046007 1926302 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770620 1770620 1674860 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1746665 1746665 1651641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964323 1964323 1850858 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046611 2046611 1926905 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047761 2047761 1928033 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777243 1777243 1681246 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096066 2096066 1974130 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422932 2422932 2285854 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264125 2264125 2131109 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887370 1887370 1777042 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246619 1246619 1158298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515255 1515255 1437865 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637164 1637164 1553212 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026257 2026257 1908346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2069198 2069198 1948773 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24346091 NS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000238 2000238 1885136 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475378 1475378 1399077 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664329 2664329 2524407 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 32 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1610990 1610990 1530218 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22157369 surgery-fixed NS 50 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 999925 999925 917148 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16785471 surgery - NOS primary 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2485111 2485111 2347811 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20630828 NS recurrent 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046004 2046004 1926299 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096113 2096113 1974177 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345379 2345379 2210051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096105 2096105 1974169 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2560113 2560113 2421537 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26826182 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770684 1770684 1674924 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1531514 1531514 1453874 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21681119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838538 1838538 1732639 lung right_upper_lobe NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23242446 surgery - NOS metastasis 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1842990 1842990 1736238 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23263831 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2426856 2426856 2289777 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226189 2226189 2093924 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346524 2346524 2211187 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965861 1965861 1852354 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965859 1965859 1852352 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1112950 1112950 1026461 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448997 surgery-fixed NS 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1103421 1103421 1017673 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 17975165 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402512 2402512 2265368 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770737 1770737 1674977 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960168 1960168 1846808 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095932 2095932 1973996 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425741 2425741 2288662 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2824351 2824351 2680160 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31543779 surgery - NOS recurrent 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264115 2264115 2131099 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246668 1246668 1158347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2788200 2788200 2645582 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 30922578 pleural effusion recurrent 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770717 1770717 1674957 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921944 1921944 1809262 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885191 1885191 1775078 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1531513 1531513 1453873 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21681119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1673294 1673294 1586348 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22225786 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937507 1937507 1824441 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637709 2637709 2498082 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264266 2264266 2131250 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422836 2422836 2285758 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547827 1547827 1469949 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed primary 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264163 2264163 2131147 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425718 2425718 2288639 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422790 2422790 2285712 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2482734 2482734 2345461 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26893581 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1174303 1174303 1086322 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402532 2402532 2265388 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095960 2095960 1974024 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770537 1770537 1674777 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421165 2421165 2284087 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1489404 1489404 1412562 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20975376 surgery-fixed primary 24 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921904 1921904 1809222 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2822189 2822189 2678049 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26373574 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1635875 1635875 1551979 lung NS NS NS carcinoma undifferentiated_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22102479 pleural effusion metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 T2111 2823148 2679002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28818608 surgery-fixed NS 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444782 1444782 1369025 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345591 2345591 2210263 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345534 2345534 2210206 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264146 2264146 2131130 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515262 1515262 1437872 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2245050 2245050 2112326 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1052967 1052967 969038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17410005 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1279047 1279047 1190343 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19487967 surgery-fixed metastasis 49 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2644797 2644797 2505084 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28625641 surgery - NOS primary 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960173 1960173 1846813 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770744 1770744 1674984 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1576791 1576791 1498232 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 56 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2819306 2819306 2675605 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 30711944 surgery - NOS recurrent 79 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2819294 2819294 2675593 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 30711944 surgery - NOS NS 63 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2819289 2819289 2675588 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 30711944 pleural effusion recurrent 66 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1992094 1992094 1877411 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow NS 75 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879489 1879489 1769991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1024766 1024766 941743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 pleural effusion recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2047769 2047769 1928041 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451768 1451768 1375817 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20615575 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345512 2345512 2210184 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838655 1838655 1732756 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965886 1965886 1852379 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2372824 2372824 2235617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25904052 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096022 2096022 1974086 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525697 2525697 2387886 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27304188 surgery-fixed metastasis ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2096303 2096303 1974367 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1587190 1587190 1508361 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS 80 ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982880 982880 898599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000165-T01-IM3 2714735 2573556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 LC130 2439290 2302131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780429 COSM710350 99385283 c.2612C>T p.A871V Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .97911 Reported in another cancer sample as somatic 26164066 surgery-fixed metastasis ENSP00000275493.2:p.Ala871Val ENST00000275493.6:c.2612C>T 7:g.55191861C>T EGFR ENST00000275493.6 3633 3236 1107782 1107782 1021685 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2549138 2549138 2410593 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27588191 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2029026 2029026 1910908 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346549 2346549 2211212 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618632 1618632 1537384 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148602 2148602 2017732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402533 2402533 2265389 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095897 2095897 1973961 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264248 2264248 2131232 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637242 1637242 1553290 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618798 1618798 1537550 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 42 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551561 1551561 1473666 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422940 2422940 2285862 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469861 1469861 1393600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2057497 2057497 1937704 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24236184 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862404 2862404 2717590 lung right_lower_lobe NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31561203 pleural effusion NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214569 2214569 2082693 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226143 2226143 2093878 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096020 2096020 1974084 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2426858 2426858 2289779 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937580 1937580 1824514 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966325 1966325 1852818 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964312 1964312 1850847 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777248 1777248 1681251 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345497 2345497 2210169 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2824350 2824350 2680159 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31543779 surgery - NOS primary 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637064 1637064 1553112 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777353 1777353 1681356 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106536 2106536 1984399 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141307 1141307 1053755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664327 2664327 2524406 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed recurrent 32 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777274 1777274 1681277 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1075801 1075801 991055 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17575133 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777362 1777362 1681365 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422923 2422923 2285845 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2349276 2349276 2213668 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25654374 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346477 2346477 2211140 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770736 1770736 1674976 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2612320 2612320 2473138 lung right NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28296233 NS NS 44 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148588 2148588 2017718 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047746 2047746 1928018 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed primary 45 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914929 1914929 1802931 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618624 1618624 1537376 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214563 2214563 2082687 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1036706 1036706 953463 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17106442 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881885 1881885 1772036 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996578 1996578 1881787 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23922984 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469510 1469510 1393249 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264344 2264344 2131328 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096303 2096303 1974367 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 146 2605107 2465998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25376516 surgery - NOS NS 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618723 1618723 1537475 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 49 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2245040 2245040 2112316 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1576788 1576788 1498229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21921847 surgery - NOS primary 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2271423 2271423 2138056 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25257380 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1465894 1465894 1389741 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 77 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770604 1770604 1674844 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425727 2425727 2288648 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421202 2421202 2284124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345455 2345455 2210127 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476897 2476897 2339666 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1658062 1658062 1572505 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22458769 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469478 1469478 1393217 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1752328 1752328 1657139 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22912354 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246643 1246643 1158322 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777422 1777422 1681425 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459525 1459525 1383468 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237676 1237676 1149423 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148520 2148520 2017650 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_S5 1863765 1754656 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 79 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002296-T01-IM3 2782972 2640755 prostate NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51800946 COSM6921640 132556733 c.2144T>C p.L715P Substitution - Missense het 38 7:55174816-55174816 + - PATHOGENIC .99068 Confirmed somatic variant 28825054 surgery-fixed metastasis 55 ENSP00000395243.3:p.Leu715Pro ENST00000454757.6:c.2144T>C 7:g.55174816T>C EGFR ENST00000275493.6 3633 3236 1884043 1884043 1773932 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23495083 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096085 2096085 1974149 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1802279 1802279 1703998 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23136191 surgery-fixed NS 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1036702 1036702 953459 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17106442 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1909756 1909756 1798273 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23559152 surgery-fixed NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878848 2878848 2733363 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27368130 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2028990 2028990 1910872 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638721 1638721 1554720 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476872 2476872 2339641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214554 2214554 2082678 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096082 2096082 1974146 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230459 1230459 1142273 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422839 2422839 2285761 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638733 1638733 1554732 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637145 1637145 1553193 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1882223 1882223 1772374 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 23392229 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 1896949 1896949 1785636 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 23542356 surgery-fixed recurrent 59 ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897851 897851 815473 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51811749 COSM6242 133217384 c.2170G>T p.V724L Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .9836 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Val724Leu ENST00000455089.5:c.2170G>T 7:g.55181314G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1074903 1074903 990157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51794784 COSM13182 132548944 c.2068G>A p.G690S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 17505415 surgery fresh/frozen primary 71 ENSP00000395243.3:p.Gly690Ser ENST00000454757.6:c.2068G>A 7:g.55174740G>A EGFR ENST00000275493.6 3633 3236 1882220 1882220 1772371 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23392229 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 NPC0001PT00237T00237 2857324 2712624 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1891317 1891317 1780686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194738 1194738 1106633 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982777 982777 898496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51788393 COSM13979 132563273 c.2035G>A p.G679S Substitution - Missense 38 7:55174029-55174029 + - PATHOGENIC .98273 Reported in another cancer sample as somatic 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Gly679Ser ENST00000454757.6:c.2035G>A 7:g.55174029G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897851 897851 815473 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51811749 COSM6242 132561254 c.2170G>T p.V724L Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .9836 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Val724Leu ENST00000454757.6:c.2170G>T 7:g.55181314G>T EGFR ENST00000275493.6 3633 3236 1166432 1166432 1078746 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51815934 COSM28607 99378283 c.2603A>G p.E868G Substitution - Missense hom 38 7:55191852-55191852 + - PATHOGENIC .96745 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 59 ENSP00000275493.2:p.Glu868Gly ENST00000275493.6:c.2603A>G 7:g.55191852A>G EGFR ENST00000275493.6 3633 3236 1166418 1166418 1078732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51815934 COSM28607 99378283 c.2603A>G p.E868G Substitution - Missense het 38 7:55191852-55191852 + - PATHOGENIC .96745 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 59 ENSP00000275493.2:p.Glu868Gly ENST00000275493.6:c.2603A>G 7:g.55191852A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 426 2267398 2134166 oesophagus middle_third NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51819303 COSM4432960 133228423 c.2609A>G p.Y870C Substitution - Missense 38 7:55198759-55198759 + - PATHOGENIC .97948 Confirmed somatic variant 25151357 surgery fresh/frozen primary 57 ENSP00000415559.1:p.Tyr870Cys ENST00000455089.5:c.2609A>G 7:g.55198759A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982880 982880 898599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 945819 945819 862345 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 16144918 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 3595 915982 833381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51775222 COSM13189 99385712 c.2351C>T p.S784F Substitution - Missense 38 7:55181360-55181360 + - PATHOGENIC .94833 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000275493.2:p.Ser784Phe ENST00000275493.6:c.2351C>T 7:g.55181360C>T EGFR ENST00000275493.6 3633 3236 2862077 2862077 2717282 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 32122695 circulating tumour metastasis 62 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1695798 1695798 1604010 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22670114 surgery - NOS NS 78 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1668446 1668446 1581739 lung right_upper_lobe NS NS carcinoma mucoepidermoid_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22526156 surgery-fixed primary 52 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 112509 1520625 1443000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51833788 COSM94181 133257899 c.1540C>T p.H514Y Substitution - Missense 38 7:55163776-55163776 + - PATHOGENIC .97598 Confirmed somatic variant 20668451 NS primary ENSP00000415559.1:p.His514Tyr ENST00000455089.5:c.1540C>T 7:g.55163776C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 907083 907083 824595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897851 897851 815473 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_S5 1863765 1754656 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 79 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002054-T01-IM3 2718359 2577180 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51839619 COSM6920482 133220821 c.2728G>A p.A910T Substitution - Missense het 38 7:55200330-55200330 + - PATHOGENIC .99154 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ala910Thr ENST00000455089.5:c.2728G>A 7:g.55200330G>A EGFR ENST00000275493.6 3633 3236 2625598 2625598 2486010 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 44 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982777 982777 898496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51788393 COSM13979 133219516 c.2035G>A p.G679S Substitution - Missense 38 7:55174029-55174029 + - PATHOGENIC .98273 Reported in another cancer sample as somatic 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Gly679Ser ENST00000455089.5:c.2035G>A 7:g.55174029G>A EGFR ENST00000275493.6 3633 3236 1174290 1174290 1086309 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 19096302 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 TCGA-06-0185-01 1910194 1798485 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774819 COSM35840 99378923 c.1951G>A p.V651M Substitution - Missense het 38 7:55173014-55173014 + - PATHOGENIC .99458 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 54 ENSP00000275493.2:p.Val651Met ENST00000275493.6:c.1951G>A 7:g.55173014G>A EGFR ENST00000275493.6 3633 3236 982887 982887 898606 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1083324 1083324 998489 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 17596643 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2161846 2161846 2030444 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24866168 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345043 2345043 2209715 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194738 1194738 1106633 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 NPC0001PT00173T00173 2857372 2712672 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 MG-070-tumor 2819006 2675305 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1166418 1166418 1078732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51843707 COSM28601 99378273 c.2135T>C p.F712S Substitution - Missense het 38 7:55173994-55173994 + - PATHOGENIC .9621 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 59 ENSP00000275493.2:p.Phe712Ser ENST00000275493.6:c.2135T>C 7:g.55173994T>C EGFR ENST00000275493.6 3633 3236 1007073 1007073 924281 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51772347 COSM17570 99378871 c.2222C>T p.P741L Substitution - Missense 38 7:55174759-55174759 + - PATHOGENIC .9905 Reported in another cancer sample as somatic 16410744 NS primary ENSP00000275493.2:p.Pro741Leu ENST00000275493.6:c.2222C>T 7:g.55174759C>T EGFR ENST00000275493.6 3633 3236 PF08 2560049 2421473 large_intestine colon sigmoid NS adenoma tubular NS NS n COSV51779162 COSM21689 99374883 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 27609830 surgery-fixed NS ENSP00000275493.2:p.Pro596Leu ENST00000275493.6:c.1787C>T 7:g.55165344C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM19-I1 2813465 2669857 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 911632 911632 829115 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1541736 1541736 1464040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21469767 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895114 1895114 1783806 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2862716 2862716 2717879 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668527 1668527 1581820 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1435970 1435970 1345249 lung left_lower_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen NS 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1166442 1166442 1078756 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1067065 1067065 983045 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1038997 1038997 955574 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1895159 1895159 1783851 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1168009 1168009 1080251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897814 897814 815436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1668454 1668454 1581747 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1135426 1135426 1047990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1983758 1983758 1869994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897828 897828 815450 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004995 1004995 922207 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-1600-01 2178073 2046371 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 329 NS NS 86 ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897851 897851 815473 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1465895 1465895 1389742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 60 ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NPC0001PT00407T00407 2857330 2712630 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 426 2267398 2134166 oesophagus middle_third NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51819303 COSM4432960 132570738 c.2609A>G p.Y870C Substitution - Missense 38 7:55198759-55198759 + - PATHOGENIC .97948 Confirmed somatic variant 25151357 surgery fresh/frozen primary 57 ENSP00000395243.3:p.Tyr870Cys ENST00000454757.6:c.2609A>G 7:g.55198759A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GB013T 2633978 2494374 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51855854 COSM6355744 133242885 c.842G>T p.C281F Substitution - Missense 38 7:55155917-55155917 + - PATHOGENIC .99445 Confirmed somatic variant 672 NS primary ENSP00000415559.1:p.Cys281Phe ENST00000455089.5:c.842G>T 7:g.55155917G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 112509 1520625 1443000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51833788 COSM94181 132594846 c.1540C>T p.H514Y Substitution - Missense 38 7:55163776-55163776 + - PATHOGENIC .97598 Confirmed somatic variant 20668451 NS primary ENSP00000395243.3:p.His514Tyr ENST00000454757.6:c.1540C>T 7:g.55163776C>T EGFR ENST00000275493.6 3633 3236 GCYC_157_T 2747576 2606279 stomach NS NS NS carcinoma NS NS NS y COSV99286174 COSM8511928 99421151 c.2464G>A p.A822T Substitution - Missense 38 7:55181473-55181473 + - PATHOGENIC .97334 Confirmed somatic variant 683 NS primary ENSP00000275493.2:p.Ala822Thr ENST00000275493.6:c.2464G>A 7:g.55181473G>A EGFR ENST00000275493.6 3633 3236 56 2760164 2618697 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51776282 COSM1168015 99373518 c.2258C>T p.P753L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Reported in another cancer sample as somatic 29876005 surgery-fixed NS ENSP00000275493.2:p.Pro753Leu ENST00000275493.6:c.2258C>T 7:g.55174795C>T EGFR ENST00000275493.6 3633 3236 2476904 2476904 2339673 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 1618883 1618883 1537635 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 22209037 surgery-fixed primary 78 ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002054-T01-IM3 2718359 2577180 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51839619 COSM6920482 132564447 c.2728G>A p.A910T Substitution - Missense het 38 7:55200330-55200330 + - PATHOGENIC .99154 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ala910Thr ENST00000454757.6:c.2728G>A 7:g.55200330G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 U373 2491105 2353751 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51804471 COSM5712404 133283894 c.1388C>T p.A463V Substitution - Missense 38 7:55161523-55161523 + - NEUTRAL .21884 Confirmed somatic variant 26496030 cell-line NS ENSP00000415559.1:p.Ala463Val ENST00000455089.5:c.1388C>T 7:g.55161523C>T EGFR ENST00000275493.6 3633 3236 2226190 2226190 2093925 lung NS NS NS carcinoma NS NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 3615 915978 833377 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51789362 COSM13184 99406147 c.2236G>A p.E746K Substitution - Missense 38 7:55174773-55174773 + - PATHOGENIC .99624 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000275493.2:p.Glu746Lys ENST00000275493.6:c.2236G>A 7:g.55174773G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007024-T01-IM5 2723398 2582219 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007024-T01-IM5 2723398 2582219 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51786507 COSM6955643 133240636 c.983C>T p.P328L Substitution - Missense het 38 7:55156644-55156644 + - PATHOGENIC .86501 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Pro328Leu ENST00000455089.5:c.983C>T 7:g.55156644C>T EGFR ENST00000275493.6 3633 3236 1052728 1052728 968799 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17368623 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924342 924342 841117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891164 1891164 1780533 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136892 1136892 1049456 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897803 897803 815425 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1549821 1549821 1471926 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450844 1450844 1374987 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 55 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453420 1453420 1377453 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1162200 1162200 1074532 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19020901 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875366 1875366 1765949 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983705 1983705 1869941 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302284 1302284 1213335 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1160966 1160966 1073302 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19002495 surgery-fixed primary 50 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226895 2226895 2094630 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1602802 1602802 1522138 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22071650 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM19-I1 2813465 2669857 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004995 1004995 922207 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1098983 1098983 1013575 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51779291 COSM26446 99389123 c.2524A>G p.N842D Substitution - Missense 38 7:55191773-55191773 + - PATHOGENIC .986 Reported in another cancer sample as somatic 18199332 surgery-fixed primary ENSP00000275493.2:p.Asn842Asp ENST00000275493.6:c.2524A>G 7:g.55191773A>G EGFR ENST00000275493.6 3633 3236 1879521 1879521 1770023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 104 2786511 2643934 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51780877 COSM26717 99375410 c.2579A>T p.K860I Substitution - Missense 38 7:55191828-55191828 + - PATHOGENIC .95726 Reported in another cancer sample as somatic 30115035 surgery-fixed NS ENSP00000275493.2:p.Lys860Ile ENST00000275493.6:c.2579A>T 7:g.55191828A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2841184 2841184 2696744 prostate NS NS NS carcinoma NS NS NS n COSV104577128 COSM9497116 132601764 c.1336A>G p.I446V Substitution - Missense 38 7:55160311-55160311 + - NEUTRAL .12941 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000395243.3:p.Ile446Val ENST00000454757.6:c.1336A>G 7:g.55160311A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LPS22 2800436 2657252 soft_tissue fat NS NS liposarcoma myxoid-round_cell NS NS y COSV99287159 COSM9110953 132614278 c.3431G>A p.G1144D Substitution - Missense 38 7:55205550-55205550 + - PATHOGENIC .90278 Confirmed somatic variant 26643872 surgery - NOS primary 48 ENSP00000395243.3:p.Gly1144Asp ENST00000454757.6:c.3431G>A 7:g.55205550G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GB013T 2633978 2494374 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51855854 COSM6355744 132581821 c.842G>T p.C281F Substitution - Missense 38 7:55155917-55155917 + - PATHOGENIC .99445 Confirmed somatic variant 672 NS primary ENSP00000395243.3:p.Cys281Phe ENST00000454757.6:c.842G>T 7:g.55155917G>T EGFR ENST00000275493.6 3633 3236 1014325 1014325 931499 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu861Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM13-I3 2813477 2669869 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28263318 surgery fresh/frozen NS 55 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-1600-01 2178073 2046371 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 329 NS NS 86 ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 U373 2491105 2353751 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51804471 COSM5712404 132620667 c.1388C>T p.A463V Substitution - Missense 38 7:55161523-55161523 + - NEUTRAL .21884 Confirmed somatic variant 26496030 cell-line NS ENSP00000395243.3:p.Ala463Val ENST00000454757.6:c.1388C>T 7:g.55161523C>T EGFR ENST00000275493.6 3633 3236 24 2570197 2431494 skin chest_wall NS NS adnexal_tumour sebaceous_carcinoma NS NS n COSV51794784 COSM13182 99375617 c.2203G>A p.G735S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 79 ENSP00000275493.2:p.Gly735Ser ENST00000275493.6:c.2203G>A 7:g.55174740G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982777 982777 898496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2226909 2226909 2094644 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 V153 1179732 1091694 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2841184 2841184 2696744 prostate NS NS NS carcinoma NS NS NS n COSV104577128 COSM9497116 133265950 c.1336A>G p.I446V Substitution - Missense 38 7:55160311-55160311 + - NEUTRAL .12941 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000415559.1:p.Ile446Val ENST00000455089.5:c.1336A>G 7:g.55160311A>G EGFR ENST00000275493.6 3633 3236 2732934 2732934 2591687 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 72 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 2906648 2906648 2760899 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 29616327 surgery-fixed recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481258 1481258 1404887 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618660 1618660 1537412 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 42 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1542297 1542297 1464600 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21782507 surgery-fixed NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2076946 2076946 1955695 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24369725 surgery-fixed recurrent 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096283 2096283 1974347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2153195 2153195 2022205 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471807 1471807 1395545 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51780206 COSM12373 133208468 c.2024C>T p.S675F Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .9768 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000415559.1:p.Ser675Phe ENST00000455089.5:c.2024C>T 7:g.55174018C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM13-I3 2813477 2669869 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28263318 surgery fresh/frozen NS 55 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 1892651 1892651 1781903 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23566546 NS recurrent ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2402472 2402472 2265328 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS 59 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1468063 1468063 1391909 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21062933 autopsy - NOS metastasis 57 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007024-T01-IM5 2723398 2582219 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51786507 COSM6955643 132579741 c.983C>T p.P328L Substitution - Missense het 38 7:55156644-55156644 + - PATHOGENIC .86501 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Pro328Leu ENST00000454757.6:c.983C>T 7:g.55156644C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007024-T01-IM5 2723398 2582219 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1891313 1891313 1780682 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1038997 1038997 955574 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668454 1668454 1581747 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897828 897828 815450 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 911632 911632 829115 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895159 1895159 1783851 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1895114 1895114 1783806 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1435970 1435970 1345249 lung left_lower_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen NS 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1135426 1135426 1047990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1168009 1168009 1080251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1983758 1983758 1869994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862716 2862716 2717879 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1067065 1067065 983045 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1166442 1166442 1078756 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897814 897814 815436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1541736 1541736 1464040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21469767 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1668527 1668527 1581820 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1098818 1098818 1013410 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51848710 COSM26438 132561077 c.2485G>A p.G829S Substitution - Missense 38 7:55191869-55191869 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 50 ENSP00000395243.3:p.Gly829Ser ENST00000454757.6:c.2485G>A 7:g.55191869G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-0649 2107982 1985843 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51791901 COSM2151461 99416512 c.991G>A p.G331R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .96902 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Gly331Arg ENST00000275493.6:c.991G>A 7:g.55155931G>A EGFR ENST00000275493.6 3633 3236 1469788 1469788 1393527 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096288 2096288 1974352 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469792 1469792 1393531 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2824352 2824352 2680161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 31543779 surgery - NOS metastasis 60 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2264423 2264423 2131407 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096301 2096301 1974365 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2731045 2731045 2589812 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing_non_differentiated NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25963410 surgery fresh/frozen NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1246733 1246733 1158412 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2582952 2582952 2444207 lung right_lower_lobe NS NS carcinoma adenocarcinoma transformed_to_squamous_cell_carcinoma NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 28024692 surgery - NOS recurrent 43 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1881363 1881363 1771514 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23362162 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2096253 2096253 1974317 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2345404 2345404 2210076 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2686019 2686019 2545054 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240668 2240668 2108199 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914936 1914936 1802938 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345472 2345472 2210144 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2033329 2033329 1914800 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24137465 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163047 2163047 2031631 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046036 2046036 1926331 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046026 2046026 1926321 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096126 2096126 1974190 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329260 1329260 1239745 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777356 1777356 1681359 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525741 2525741 2387929 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000214 2000214 1885112 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264141 2264141 2131125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264136 2264136 2131120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2582952 2582952 2444207 lung right_lower_lobe NS NS carcinoma adenocarcinoma transformed_to_squamous_cell_carcinoma NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28024692 surgery - NOS recurrent 43 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264178 2264178 2131162 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1465895 1465895 1389742 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770725 1770725 1674965 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047774 2047774 1928046 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637258 1637258 1553306 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203089 2203089 2071347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 812 1716354 1623916 lung right_upper_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22733594 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264102 2264102 2131086 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2136674 2136674 2006225 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095884 2095884 1973948 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240656 2240656 2108187 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081930 2081930 1960352 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24440279 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-VS033-T2 2869855 2724852 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51776559 COSM4892884 133209480 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 26950094 surgery - NOS NS 73 ENSP00000415559.1:p.Pro100Ser ENST00000455089.5:c.298C>T 7:g.55143362C>T EGFR ENST00000275493.6 3633 3236 1637084 1637084 1553132 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1223898 1223898 1135730 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19517135 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777324 1777324 1681327 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014318 1014318 931492 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 16931592 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1768459 1768459 1672699 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22952784 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025384 2025384 1907473 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329257 1329257 1239742 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2686017 2686017 2545052 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402518 2402518 2265374 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179662 1179662 1091624 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1076409 1076409 991663 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17607119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2078469 2078469 1957188 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346485 2346485 2211148 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1882241 1882241 1772392 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23392229 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838665 1838665 1732766 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047123 2047123 1927405 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24201163 surgery-fixed recurrent 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1075012 1075012 990266 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618660 1618660 1537412 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 42 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476875 2476875 2339644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1795769 1795769 1697517 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23110940 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346476 2346476 2211139 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25695221 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468873 1468873 1392612 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21128242 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996944 1996944 1882153 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475407 1475407 1399106 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964305 1964305 1850840 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844331 1844331 1737365 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1729984 1729984 1635955 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22677909 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264230 2264230 2131214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000267 2000267 1885165 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083060 1083060 998225 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17685931 surgery-fixed NS 82 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770663 1770663 1674903 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163045 2163045 2031629 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345457 2345457 2210129 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469177 1469177 1392916 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21130517 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421231 2421231 2284153 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1597345 1597345 1517833 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19643949 NS NS 47 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096159 2096159 1974223 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921727 1921727 1809045 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense hom + - Reported in another cancer sample as somatic 23620765 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1312385 1312385 1223294 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 19723643 surgery fresh/frozen NS 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096102 2096102 1974166 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1835505 1835505 1730537 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23242440 NS NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120923 1120923 1034079 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2686010 2686010 2545045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1053134 1053134 969205 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17409961 surgery - NOS NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469477 1469477 1393216 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937565 1937565 1824499 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680594 2680594 2539867 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493335 1493335 1416325 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1523388 1523388 1445760 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21626329 surgery-fixed recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937568 1937568 1824502 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141295 1141295 1053743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2007100 2007100 1889981 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23790173 surgery-fixed NS 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014113 1014113 931287 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16865253 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551481 1551481 1473586 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921912 1921912 1809230 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705473 1705473 1613379 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027808 2027808 1909711 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476904 2476904 2339673 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2142058 2142058 2011276 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24468202 surgery - NOS NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1112959 1112959 1026470 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18448997 surgery-fixed NS 49 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705480 1705480 1613386 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983150 983150 898868 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203085 2203085 2071343 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680694 2680694 2539967 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587280 1587280 1508451 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1355111 1355111 1265206 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20409020 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770628 1770628 1674868 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515257 1515257 1437867 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179650 1179650 1091612 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1522877 1522877 1445249 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21642865 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1059472 1059472 975542 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17429313 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469449 1469449 1393188 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-VS033-T2 2869855 2724852 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51790737 COSM3639739 133260744 c.1486C>T p.L496F Substitution - Missense 38 7:55161621-55161621 + - NEUTRAL .0484 Confirmed somatic variant 26950094 surgery - NOS NS 73 ENSP00000415559.1:p.Leu496Phe ENST00000455089.5:c.1486C>T 7:g.55161621C>T EGFR ENST00000275493.6 3633 3236 1777332 1777332 1681335 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777401 1777401 1681404 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2078391 2078391 1957110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24336155 surgery-fixed NS 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118424 2118424 1992659 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1914895 1914895 1802897 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1076406 1076406 991660 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17607119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1874743 1874743 1765334 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23425899 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965842 1965842 1852335 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345796 2345796 2210468 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25281710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770716 1770716 1674956 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230466 1230466 1142280 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637123 1637123 1553171 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770598 1770598 1674838 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964325 1964325 1850860 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878859 2878859 2733374 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27368130 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081821 2081821 1960243 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481317 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770612 1770612 1674852 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1081582 1081582 996801 lung right_upper_lobe NS NS other hyperplasia NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17618248 surgery-fixed NS 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1530988 1530988 1453360 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264190 2264190 2131174 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777264 1777264 1681267 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774675 1774675 1678899 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS primary 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1732077 1732077 1638043 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21622214 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346530 2346530 2211193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105811 2105811 1983849 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1672445 1672445 1585499 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21729655 surgery-fixed metastasis 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264151 2264151 2131135 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493365 1493365 1416355 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966327 1966327 1852820 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2265122 2265122 2132026 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994671 cerebrospinal fluid metastasis 47 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2824352 2824352 2680161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 31543779 surgery - NOS metastasis 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2424727 2424727 2287648 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25784657 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047819 2047819 1928091 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665707 2665707 2525416 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS primary 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046617 2046617 1926911 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878780 2878780 2733295 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22006985 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096301 2096301 1974365 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515234 1515234 1437844 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083806 1083806 998971 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-VS033-T2 2869855 2724852 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51776559 COSM4892884 132554171 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 26950094 surgery - NOS NS 73 ENSP00000395243.3:p.Pro100Ser ENST00000454757.6:c.298C>T 7:g.55143362C>T EGFR ENST00000275493.6 3633 3236 1451764 1451764 1375813 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20615575 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2265103 2265103 2132007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994671 cerebrospinal fluid metastasis 52 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1338231 1338231 1248616 lung right_upper_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20357619 surgery - NOS recurrent 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264138 2264138 2131122 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921890 1921890 1809208 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23609009 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2361981 2361981 2224924 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25726043 NS recurrent 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2686015 2686015 2545050 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 29199710 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1465905 1465905 1389752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1795766 1795766 1697514 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23110940 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081937 2081937 1960359 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24440279 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887414 1887414 1777086 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246700 1246700 1158379 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096166 2096166 1974230 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1731696 1731696 1637662 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22806307 NS NS 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2106552 2106552 1984415 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24575772 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421210 2421210 2284132 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459496 1459496 1383439 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637202 1637202 1553250 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230454 1230454 1142268 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214535 2214535 2082659 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2525682 2525682 2387871 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27304188 NS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-VS033-T2 2869855 2724852 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51790737 COSM3639739 132597151 c.1486C>T p.L496F Substitution - Missense 38 7:55161621-55161621 + - NEUTRAL .0484 Confirmed somatic variant 26950094 surgery - NOS NS 73 ENSP00000395243.3:p.Leu496Phe ENST00000454757.6:c.1486C>T 7:g.55161621C>T EGFR ENST00000275493.6 3633 3236 1484300 1484300 1407926 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51778659 COSM14070 99374271 c.2588G>A p.G863D Substitution - Missense 38 7:55191837-55191837 + - PATHOGENIC .92688 Reported in another cancer sample as somatic 21266046 surgery-fixed primary 66 ENSP00000275493.2:p.Gly863Asp ENST00000275493.6:c.2588G>A 7:g.55191837G>A EGFR ENST00000275493.6 3633 3236 1093895 1093895 1008597 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18061305 pleural effusion NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1500179 1500179 1423058 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21258250 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875368 1875368 1765951 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453487 1453487 1377520 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450864 1450864 1375007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875350 1875350 1765933 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1135416 1135416 1047980 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983691 1983691 1869927 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895074 1895074 1783766 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1625786 1625786 1543010 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1593001 1593001 1513927 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899312 899312 816924 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895127 1895127 1783819 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891281 1891281 1780650 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1160967 1160967 1073303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19002495 surgery-fixed primary 61 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1098814 1098814 1013406 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 57 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1429324 1429324 1338775 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450941 1450941 1375084 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 53 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453419 1453419 1377452 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NPC0001PT00407T00407 2857330 2712630 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2539014 2539014 2400609 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 99392475 c.2390G>C p.C797S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Reported in another cancer sample as somatic 26749488 NS recurrent 57 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2390G>C 7:g.55181399G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-HC-7075-01 2121474 1995710 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51805358 COSM3674958 133252789 c.1819G>T p.G607W Substitution - Missense 38 7:55173017-55173017 + - PATHOGENIC .99788 Confirmed somatic variant 435 NS NS 63 ENSP00000415559.1:p.Gly607Trp ENST00000455089.5:c.1819G>T 7:g.55173017G>T EGFR ENST00000275493.6 3633 3236 1879516 1879516 1770018 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2603437 2603437 2464328 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSM1169669 178386037 c.? p.T263P Substitution - Missense + - Reported in another cancer sample as somatic 28042970 surgery-fixed NS 46 ENSP00000275493.2:p.Thr263Pro EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-D5-6928-01 1651267 1566054 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51794983 COSM1451619 132592301 c.3152C>T p.S1051F Substitution - Missense 38 7:55205271-55205271 + - NEUTRAL .09807 Confirmed somatic variant 376 NS NS 80 ENSP00000395243.3:p.Ser1051Phe ENST00000454757.6:c.3152C>T 7:g.55205271C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-HC-7075-01 2121474 1995710 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51805358 COSM3674958 132590571 c.1819G>T p.G607W Substitution - Missense 38 7:55173017-55173017 + - PATHOGENIC .99788 Confirmed somatic variant 435 NS NS 63 ENSP00000395243.3:p.Gly607Trp ENST00000454757.6:c.1819G>T 7:g.55173017G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5 1489412 1412570 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21102258 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-50-6595-01 1780173 1684172 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 74 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S004384 1027694 944670 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5 1489412 1412570 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21102258 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LCSC_1 946053 862579 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1625796 1625796 1543020 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1479953 1479953 1403613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1197350 1197350 1109245 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19276259 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1715001 1715001 1622580 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22710815 surgery-fixed primary 77 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1135419 1135419 1047983 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891275 1891275 1780644 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136882 1136882 1049446 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2625556 2625556 2485968 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1631943 1631943 1548813 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22321545 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1089596 1089596 1004543 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17941001 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226904 2226904 2094639 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1110469 1110469 1024347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1242317 1242317 1154047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19671738 surgery - NOS metastasis 56 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 946822 946822 863345 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 924344 924344 841119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16052218 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895099 1895099 1783791 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1098858 1098858 1013450 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891261 1891261 1780630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 5313 915983 833382 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51860329 COSM13190 99392465 c.2375T>C p.L792P Substitution - Missense 38 7:55181384-55181384 + - PATHOGENIC .95089 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000275493.2:p.Leu792Pro ENST00000275493.6:c.2375T>C 7:g.55181384T>C EGFR ENST00000275493.6 3633 3236 1593005 1593005 1513931 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136870 1136870 1049434 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226894 2226894 2094629 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895157 1895157 1783849 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450846 1450846 1374989 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 44 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1625795 1625795 1543019 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1320682 1320682 1231569 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20155428 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2372590 2372590 2235383 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24487311 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897832 897832 815454 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1860416 1860416 1751357 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2064715 2064715 1944792 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862720 2862720 2717883 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1610922 1610922 1530150 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22157931 pleural effusion NS 61 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897826 897826 815448 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899318 899318 816930 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1576799 1576799 1498240 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 79 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879531 1879531 1770033 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879522 1879522 1770024 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879491 1879491 1769993 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1007074 1007074 924282 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 16410744 NS primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005123-T01-IM5 2721527 2580348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 NS metastasis ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005123-T01-IM5 2721527 2580348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 NS metastasis ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 NPC0001PT00004T00004 2857337 2712637 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 109594 2812900 2669314 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 66 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1453418 1453418 1377451 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1043873 1043873 960214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 11-18-ER1-7 1731373 1637339 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22815900 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 911618 911618 829101 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1093894 1093894 1008596 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18061305 pleural effusion NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895162 1895162 1783854 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920151 920151 837231 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 81 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1000052 1000052 917275 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136883 1136883 1049447 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 HCC4011 2776306 2634442 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29681454 NS NS 53 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1000050 1000050 917273 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16778591 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1990894 1990894 1876229 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1089134 1089134 1004088 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1479941 1479941 1403601 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891227 1891227 1780596 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1074949 1074949 990203 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17573511 fine needle aspirate metastasis 71 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P92 1179743 1091705 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 52 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1075000 1075000 990254 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17565015 fine needle aspirate NS 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1168013 1168013 1080255 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1043865 1043865 960206 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192902 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891289 1891289 1780658 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891188 1891188 1780557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2064717 2064717 1944794 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875355 1875355 1765938 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1522947 1522947 1445319 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 60 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2539014 2539014 2400609 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 26749488 NS recurrent 57 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004984 1004984 922196 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004984 1004984 922196 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876039 2876039 2730554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876039 2876039 2730554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 66 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 MG-198-tumor 2819083 2675382 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 NPC0001PT00178T00178 2857362 2712662 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2425787 2425787 2288708 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM30754 178378833 c.? p.L747P Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu747Pro EGFR ENST00000275493.6 3633 3236 488 2605109 2466000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 25376516 surgery - NOS NS 50 ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GB051T 2634016 2494412 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51846120 COSM6354678 132608129 c.1838T>A p.L613Q Substitution - Missense 38 7:55173036-55173036 + - PATHOGENIC .99616 Confirmed somatic variant 672 NS primary ENSP00000395243.3:p.Leu613Gln ENST00000454757.6:c.1838T>A 7:g.55173036T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GB051T 2634016 2494412 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51846086 COSM6354719 132608112 c.178G>A p.V60M Substitution - Missense 38 7:55142375-55142375 + - PATHOGENIC .96004 Confirmed somatic variant 672 NS primary ENSP00000395243.3:p.Val60Met ENST00000454757.6:c.178G>A 7:g.55142375G>A EGFR ENST00000275493.6 3633 3236 1103807 1103807 1018059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 18271876 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2819294 2819294 2675593 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM24429 178380423 c.? p.E709G Substitution - Missense + - Reported in another cancer sample as somatic 30711944 surgery - NOS NS 63 ENSP00000275493.2:p.Glu709Gly EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GB051T 2634016 2494412 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51846120 COSM6354678 133272758 c.1838T>A p.L613Q Substitution - Missense 38 7:55173036-55173036 + - PATHOGENIC .99616 Confirmed somatic variant 672 NS primary ENSP00000415559.1:p.Leu613Gln ENST00000455089.5:c.1838T>A 7:g.55173036T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GB051T 2634016 2494412 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51846086 COSM6354719 133272732 c.178G>A p.V60M Substitution - Missense 38 7:55142375-55142375 + - PATHOGENIC .96004 Confirmed somatic variant 672 NS primary ENSP00000415559.1:p.Val60Met ENST00000455089.5:c.178G>A 7:g.55142375G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S0389 897615 815238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15118125 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004523-T01-IM5 2720924 2579745 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51780877 COSM26717 132548732 c.2444A>T p.K815I Substitution - Missense het 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Lys815Ile ENST00000454757.6:c.2444A>T 7:g.55191828A>T EGFR ENST00000275493.6 3633 3236 LUAD-NYU1093 1765123 1669443 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 61 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004523-T01-IM5 2720924 2579745 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51780877 COSM26717 133203719 c.2444A>T p.K815I Substitution - Missense het 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Lys815Ile ENST00000455089.5:c.2444A>T 7:g.55191828A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S0389 897615 815238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15118125 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-50-6595-01 1780173 1684172 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 74 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2841131 2841131 2696691 prostate NS NS NS carcinoma NS NS NS n COSV51862598 COSM6938266 99374093 c.2024G>A p.R675Q Substitution - Missense 38 7:55173087-55173087 + - PATHOGENIC .98305 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000275493.2:p.Arg675Gln ENST00000275493.6:c.2024G>A 7:g.55173087G>A EGFR ENST00000275493.6 3633 3236 2026272 2026272 1908361 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM23613 178378830 c.? p.G719D Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Gly719Asp EGFR ENST00000275493.6 3633 3236 1097611 1097611 1012272 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM23613 178378830 c.? p.G719D Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Gly719Asp EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1098818 1098818 1013410 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51848710 COSM26438 133217212 c.2485G>A p.G829S Substitution - Missense 38 7:55191869-55191869 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 50 ENSP00000415559.1:p.Gly829Ser ENST00000455089.5:c.2485G>A 7:g.55191869G>A EGFR ENST00000275493.6 3633 3236 CT35 1063207 979252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 75 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471807 1471807 1395545 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51780206 COSM12373 132553376 c.2024C>T p.S675F Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .9768 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000395243.3:p.Ser675Phe ENST00000454757.6:c.2024C>T 7:g.55174018C>T EGFR ENST00000275493.6 3633 3236 1996927 1996927 1882136 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM53180 178383586 c.? p.G873E Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 64 ENSP00000275493.2:p.Gly873Glu EGFR ENST00000275493.6 3633 3236 2064707 2064707 1944784 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24251405 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983751 1983751 1869987 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1627722 1627722 1544634 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22302407 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2239182 2239182 2106714 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 25130612 fine needle aspirate NS 48 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1005361 1005361 922573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16613660 surgery fresh/frozen NS 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226873 2226873 2094608 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1202557 1202557 1114443 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1067076 1067076 983056 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899335 899335 816947 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2733662 2733662 2592415 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 29721166 cerebrospinal fluid metastasis 71 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983734 1983734 1869970 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2479711 2479711 2342457 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 26923333 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-50-5944-01 1780167 1684166 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897841 897841 815463 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226881 2226881 2094616 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1110461 1110461 1024339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1083996 1083996 999161 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17785547 surgery fresh/frozen primary 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302277 1302277 1213328 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875800 1875800 1766383 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23302304 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1879546 1879546 1770048 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 17306 1423828 1333856 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2239182 2239182 2106714 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 25130612 fine needle aspirate NS 48 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879519 1879519 1770021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1673297 1673297 1586351 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22225786 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2864824 2864824 2719954 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM22423 178380012 c.? p.P733S Substitution - Missense + - Reported in another cancer sample as somatic 30391211 surgery-fixed NS 69 ENSP00000275493.2:p.Pro733Ser EGFR ENST00000275493.6 3633 3236 4990 915974 833373 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51802602 COSM13181 99393727 c.2198C>T p.P733L Substitution - Missense 38 7:55174735-55174735 + - PATHOGENIC .99806 Reported in another cancer sample as somatic 16014883 surgery-fixed NS ENSP00000275493.2:p.Pro733Leu ENST00000275493.6:c.2198C>T 7:g.55174735C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S004384 1027694 944670 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1465898 1465898 1389745 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 82 ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 17306 1423828 1333856 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2778634 2778634 2636688 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS n COSV51859563 COSM6910210 99376263 c.2509G>A p.D837N Substitution - Missense 38 7:55191758-55191758 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 24372748 surgery-fixed NS ENSP00000275493.2:p.Asp837Asn ENST00000275493.6:c.2509G>A 7:g.55191758G>A EGFR ENST00000275493.6 3633 3236 BL-18-T40375 2905680 2759936 NS NS NS NS malignant_melanoma NS NS NS n COSV51816692 COSM6503372 99407654 c.3040G>A p.D1014N Substitution - Missense 38 7:55201281-55201281 + - PATHOGENIC .99528 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Asp1014Asn ENST00000275493.6:c.3040G>A 7:g.55201281G>A EGFR ENST00000275493.6 3633 3236 2087352 2087352 1965635 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 24501009 surgery - NOS NS ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 2025445 2025445 1907534 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1074903 1074903 990157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51794784 COSM13182 133203905 c.2068G>A p.G690S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 17505415 surgery fresh/frozen primary 71 ENSP00000415559.1:p.Gly690Ser ENST00000455089.5:c.2068G>A 7:g.55174740G>A EGFR ENST00000275493.6 3633 3236 2346518 2346518 2211181 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM1166943 178385114 c.? p.V769L Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Val769Leu EGFR ENST00000275493.6 3633 3236 2862176 2862176 2717378 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51862598 COSM6938266 99374093 c.2024G>A p.R675Q Substitution - Missense 38 7:55173087-55173087 + - PATHOGENIC .98305 Confirmed somatic variant 27873319 surgery fresh/frozen NS 77 ENSP00000275493.2:p.Arg675Gln ENST00000275493.6:c.2024G>A 7:g.55173087G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 907083 907083 824595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1459530 1459530 1383473 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2757125 2757125 2615768 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 99375713 c.2318A>T p.H773L Substitution - Missense 38 7:55181327-55181327 + - PATHOGENIC .98404 Reported in another cancer sample as somatic 29858019 circulating tumour recurrent 50 ENSP00000275493.2:p.His773Leu ENST00000275493.6:c.2318A>T 7:g.55181327A>T EGFR ENST00000275493.6 3633 3236 BL-17-X19682 2905664 2759920 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51824002 COSM6937752 99404206 c.2794C>T p.R932C Substitution - Missense 38 7:55198809-55198809 + - PATHOGENIC .91422 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000275493.2:p.Arg932Cys ENST00000275493.6:c.2794C>T 7:g.55198809C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1879560 1879560 1770062 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1816947 1816947 1716115 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1098982 1098982 1013574 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51768262 COSM26445 99377063 c.2300C>T p.A767V Substitution - Missense het 38 7:55181309-55181309 + - PATHOGENIC .97799 Reported in another cancer sample as somatic 18199332 surgery-fixed primary ENSP00000275493.2:p.Ala767Val ENST00000275493.6:c.2300C>T 7:g.55181309C>T EGFR ENST00000275493.6 3633 3236 2732925 2732925 2591678 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 75 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001260 1001260 918483 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2273784 2273784 2140344 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM4389219 178384668 c.? p.G796D Substitution - Missense + - Reported in another cancer sample as somatic 25300933 surgery-fixed NS ENSP00000275493.2:p.Gly796Asp EGFR ENST00000275493.6 3633 3236 2422805 2422805 2285727 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2757125 2757125 2615768 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Reported in another cancer sample as somatic 29858019 circulating tumour recurrent 50 ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 1542158 1542158 1464461 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2862398 2862398 2717584 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 31561203 surgery - NOS metastasis 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1113047 1113047 1026548 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 18458038 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1591001 1591001 1512117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1591000 1591000 1512116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2637630 2637630 2498003 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 70 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1120916 1120916 1034072 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 106 898382 815994 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862077 2862077 2717282 lung left_bronchus NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Reported in another cancer sample as somatic 32122695 circulating tumour metastasis 62 ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001260 1001260 918483 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2625552 2625552 2485964 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 1531006 1531006 1453378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21527506 fine needle aspirate metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 488 2605109 2466000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25376516 surgery - NOS NS 50 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2096245 2096245 1974309 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2346518 2346518 2211181 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1887389 1887389 1777061 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218546 2218546 2086557 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444739 1444739 1368982 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345533 2345533 2210205 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345538 2345538 2210210 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479103 1479103 1402796 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705463 1705463 1613369 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095891 2095891 1973955 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096129 2096129 1974193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000218 2000218 1885116 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474447 2474447 2337216 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027779 2027779 1909682 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422922 2422922 2285844 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083802 1083802 998967 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2139583 2139583 2009057 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24653640 NS NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887426 1887426 1777098 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205956 2205956 2074189 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179671 1179671 1091633 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18594314 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246713 1246713 1158392 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2205982 2205982 2074215 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24994038 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676423 1676423 1589191 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027812 2027812 1909715 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1542158 1542158 1464461 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21788562 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1672454 1672454 1585508 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21729655 surgery-fixed primary 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983164 983164 898882 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045972 2045972 1926267 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1465898 1465898 1389745 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 82 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264204 2264204 2131188 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618052 1618052 1536848 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22191026 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1967531 1967531 1854023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23807543 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777330 1777330 1681333 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010754-T01-IM5 2830302 2686117 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51805749 COSM6976991 133203538 c.2509G>A p.A837T Substitution - Missense 38 7:55192784-55192784 + - PATHOGENIC .95513 Confirmed somatic variant 30205045 surgery-fixed primary 54 ENSP00000415559.1:p.Ala837Thr ENST00000455089.5:c.2509G>A 7:g.55192784G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010754-T01-IM5 2830302 2686117 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51805749 COSM6976991 132548558 c.2509G>A p.A837T Substitution - Missense 38 7:55192784-55192784 + - PATHOGENIC .95513 Confirmed somatic variant 30205045 surgery-fixed primary 54 ENSP00000395243.3:p.Ala837Thr ENST00000454757.6:c.2509G>A 7:g.55192784G>A EGFR ENST00000275493.6 3633 3236 24 897185 814808 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CTS107 2393050 2255881 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 49 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CTS107 2393050 2255881 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 25189529 surgery fresh/frozen NS 49 ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 2011177 2011177 1893815 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24002608 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2157026 2157026 2026001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2840787 2840787 2696347 prostate NS NS NS carcinoma NS NS NS n COSV51785413 COSM1176673 99382805 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000275493.2:p.Arg252His ENST00000275493.6:c.755G>A 7:g.55154018G>A EGFR ENST00000275493.6 3633 3236 1706966 1706966 1614872 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22722787 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2240674 2240674 2108205 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25179728 NS NS 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218536 2218536 2086547 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937539 1937539 1824473 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179105 1179105 1091067 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19185949 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027804 2027804 1909707 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1653412 1653412 1568199 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22333630 NS NS 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2482731 2482731 2345458 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26893581 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770676 1770676 1674916 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887384 1887384 1777056 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264236 2264236 2131220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878779 2878779 2733294 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22006985 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1430059 1430059 1339477 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20705455 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1587276 1587276 1508447 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21841502 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345526 2345526 2210198 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148620 2148620 2017750 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422942 2422942 2285864 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937544 1937544 1824478 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1113047 1113047 1026548 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18458038 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493347 1493347 1416337 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264327 2264327 2131311 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996577 1996577 1881786 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23922984 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214571 2214571 2082695 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770515 1770515 1674755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591000 1591000 1512116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887405 1887405 1777077 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346531 2346531 2211194 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1514598 1514598 1437208 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21558399 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966324 1966324 1852817 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264315 2264315 2131299 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2228276 2228276 2096006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1029250 1029250 946121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16921488 pleural effusion NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246710 1246710 1158389 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1882447 1882447 1772583 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23379755 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920030 920030 837109 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982866 982866 898585 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1062874 1062874 978919 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17409866 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422789 2422789 2285711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25456362 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770690 1770690 1674930 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637630 2637630 2498003 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264090 2264090 2131074 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1844351 1844351 1737385 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23291256 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1120916 1120916 1034072 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18509184 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965885 1965885 1852378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476858 2476858 2339627 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2081914 2081914 1960336 lung NS NS NS carcinoma NS NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24478319 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618797 1618797 1537549 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22215752 surgery-fixed NS 63 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469815 1469815 1393554 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1590997 1590997 1512113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2153080 2153080 2022090 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24789720 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1996926 1996926 1882135 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 23912954 fixed - NOS NS 48 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1075804 1075804 991058 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 17575133 fixed - NOS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1246740 1246740 1158419 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1981033 1981033 1867269 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2218527 2218527 2086538 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1075804 1075804 991058 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17575133 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734159 1734159 1640108 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22843912 blood-bone marrow recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2156996 2156996 2025971 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2346525 2346525 2211188 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25687872 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163049 2163049 2031633 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618749 1618749 1537501 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1329251 1329251 1239736 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960189 1960189 1846829 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476858 2476858 2339627 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469393 1469393 1393132 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2136677 2136677 2006228 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24457318 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960183 1960183 1846823 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1963283 1963283 1849831 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23599349 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1734084 1734084 1640033 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22842370 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1730081 1730081 1636052 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22753836 surgery-fixed NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1855999 1855999 1748552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23337026 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230449 1230449 1142263 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680688 2680688 2539961 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444778 1444778 1369021 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2819306 2819306 2675605 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 30711944 surgery - NOS recurrent 79 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838729 1838729 1732830 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1877565 1877565 1768126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23408463 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CTS107 2393050 2255881 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 49 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CTS107 2393050 2255881 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 25189529 surgery fresh/frozen NS 49 ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1879560 1879560 1770062 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1816947 1816947 1716115 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2345429 2345429 2210101 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665701 2665701 2525410 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS primary 75 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096099 2096099 1974163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1338233 1338233 1248617 lung right_upper_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20357619 surgery - NOS NS 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770608 1770608 1674848 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026242 2026242 1908331 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2349272 2349272 2213664 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25654374 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1083809 1083809 998974 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17761979 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1052964 1052964 969035 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17410005 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1612909 1612909 1532137 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18083107 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000229 2000229 1885127 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965822 1965822 1852315 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618797 1618797 1537549 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2214564 2214564 2082688 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25061320 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1336420 1336420 1246805 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20430469 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264083 2264083 2131067 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1638774 1638774 1554773 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321542 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618969 1618969 1537691 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22019513 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1774673 1774673 1678897 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22993320 surgery - NOS primary 84 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881913 1881913 1772064 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2118439 2118439 1992674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24568474 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1162974 1162974 1075297 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18992959 NS primary 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1590997 1590997 1512113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1173410 1173410 1085494 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19144441 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996938 1996938 1882147 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23912954 fixed - NOS NS 42 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345391 2345391 2210063 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141280 1141280 1053728 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2819294 2819294 2675593 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 30711944 surgery - NOS NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1795764 1795764 1697512 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23110940 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591014 1591014 1512130 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2474439 2474439 2337208 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25886900 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770525 1770525 1674765 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345423 2345423 2210095 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705470 1705470 1613376 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345082 2345082 2209754 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345048 2345048 2209720 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 BL-18-T40375 2905680 2759936 NS NS NS NS malignant_melanoma NS NS NS n COSV51830943 COSM3639753 99417416 c.2764G>A p.E922K Substitution - Missense 38 7:55198779-55198779 + - PATHOGENIC .98622 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Glu922Lys ENST00000275493.6:c.2764G>A 7:g.55198779G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920030 920030 837109 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1329247 1329247 1239732 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20236686 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770740 1770740 1674980 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2078482 2078482 1957201 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2245047 2245047 2112323 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24676429 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1732137 1732137 1638103 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21622214 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1921726 1921726 1809044 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense hom + - Reported in another cancer sample as somatic 23620765 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1986161 1986161 1872397 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23788756 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1230458 1230458 1142272 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19536777 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2664341 2664341 2524413 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28396313 surgery-fixed primary 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937537 1937537 1824471 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2078465 2078465 1957184 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 NSCLC-13 1325807 1236303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20207772 surgery-fixed NS 45 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2057473 2057473 1937682 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24236184 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1514596 1514596 1437206 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21558399 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2203097 2203097 2071355 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24965407 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1660247 1660247 1574520 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21411993 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1656132 1656132 1570789 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21311943 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965856 1965856 1852349 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264129 2264129 2131113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1213635 1213635 1125502 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18978556 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264114 2264114 2131098 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000192 2000192 1885090 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1081592 1081592 996811 lung left_upper_lobe NS NS other hyperplasia NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17618248 surgery-fixed NS 61 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004990 1004990 922202 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1837423 1837423 1731622 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1166943 178385114 c.? p.V769L Substitution - Missense + - Reported in another cancer sample as somatic 23242437 NS NS ENSP00000275493.2:p.Val769Leu EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982866 982866 898585 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1166430 1166430 1078744 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773206 COSM28603 99389206 c.2293G>A p.V765M Substitution - Missense het 38 7:55181302-55181302 + - PATHOGENIC .97963 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 51 ENSP00000275493.2:p.Val765Met ENST00000275493.6:c.2293G>A 7:g.55181302G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982777 982777 898496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2226909 2226909 2094644 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004990 1004990 922202 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2665553 2665553 2525262 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51789625 COSM13197 132549922 c.2455G>A p.A819T Substitution - Missense 38 7:55191839-55191839 + - PATHOGENIC .9615 Confirmed somatic variant 28984303 surgery-fixed NS ENSP00000395243.3:p.Ala819Thr ENST00000454757.6:c.2455G>A 7:g.55191839G>A EGFR ENST00000275493.6 3633 3236 2637616 2637616 2497989 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28104619 circulating tumour recurrent 51 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2228267 2228267 2096001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25103305 blood-bone marrow NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2045956 2045956 1926251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2824227 2824227 2680045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 31542322 circulating tumour recurrent 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469805 1469805 1393544 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2665674 2665674 2525383 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28978102 surgery - NOS recurrent 63 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1878635 1878635 1769196 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 23407566 surgery - NOS recurrent 66 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618696 1618696 1537448 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 82 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2476862 2476862 2339631 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2025436 2025436 1907525 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2032220 2032220 1913691 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 24105277 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618802 1618802 1537554 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1498646 1498646 1421524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21315472 surgery - NOS metastasis 57 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812087 2812087 2668553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51823614 COSM4170219 132547383 c.2120C>T p.S707F Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98332 Confirmed somatic variant 31534501 circulating tumour NS 76 ENSP00000395243.3:p.Ser707Phe ENST00000454757.6:c.2120C>T 7:g.55174792C>T EGFR ENST00000275493.6 3633 3236 2000068 2000068 1884966 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS 74 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1914888 1914888 1802890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2087352 2087352 1965635 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24501009 surgery - NOS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2096290 2096290 1974354 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2595764 2595764 2456640 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MSU2-a 2809971 2666633 large_intestine caecum NS NS adenoma villous NS NS y COSV51784286 COSM6652281 133211716 c.116C>T p.T39M Substitution - Missense 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000415559.1:p.Thr39Met ENST00000455089.5:c.116C>T 7:g.55142313C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0012113-T01-IM5 2727253 2586074 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51851189 COSM6982714 132562604 c.1270T>G p.L424V Substitution - Missense het 38 7:55160245-55160245 + - NEUTRAL .32338 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu424Val ENST00000454757.6:c.1270T>G 7:g.55160245T>G EGFR ENST00000275493.6 3633 3236 2345106 2345106 2209778 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 1837423 1837423 1731622 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 23242437 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2425725 2425725 2288646 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2271424 2271424 2138057 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25257380 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1062882 1062882 978927 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17387741 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1591030 1591030 1512146 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22052230 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421158 2421158 2284080 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2027811 2027811 1909714 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24035188 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1795772 1795772 1697520 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23110940 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2045956 2045956 1926251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1695699 1695699 1603911 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22673630 surgery - NOS metastasis 50 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1996581 1996581 1881790 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23922984 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777276 1777276 1681279 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1960174 1960174 1846814 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22826471 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1875691 1875691 1766274 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22797485 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469376 1469376 1393115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770635 1770635 1674875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1029252 1029252 946123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16921488 pleural effusion NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264187 2264187 2131171 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096095 2096095 1974159 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965277 1965277 1851772 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23803047 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770697 1770697 1674937 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226173 2226173 2093908 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1878635 1878635 1769196 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23407566 surgery - NOS recurrent 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1122183 1122183 1035227 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18418018 surgery - NOS NS 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046064 2046064 1926359 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2402529 2402529 2265385 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24842519 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881901 1881901 1772052 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 78 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476862 2476862 2339631 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096290 2096290 1974354 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095934 2095934 1973998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770507 1770507 1674747 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237687 1237687 1149434 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1585320 1585320 1506641 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22011666 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422925 2422925 2285847 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1223075 1223075 1134907 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 19473722 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1676419 1676419 1589187 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22572014 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2025436 2025436 1907525 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23932319 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2537655 2537655 2399296 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27177916 NS NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680734 2680734 2540007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2595764 2595764 2456640 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27538584 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1493336 1493336 1416326 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20150826 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226156 2226156 2093891 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479083 1479083 1402776 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535041 1535041 1457376 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047775 2047775 1928047 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1696867 1696867 1604995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22674612 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2273790 2273790 2140350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25300933 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618802 1618802 1537554 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345438 2345438 2210110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096064 2096064 1974128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551536 1551536 1473641 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1838554 1838554 1732655 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22591345 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264238 2264238 2131222 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2476890 2476890 2339659 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 26862733 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1966317 1966317 1852810 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2878787 2878787 2733302 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22006985 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2264437 2264437 2131421 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25152623 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469343 1469343 1393082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046616 2046616 1926910 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24183104 cytological brushing NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618688 1618688 1537440 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1535034 1535034 1457369 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21720997 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345564 2345564 2210236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881917 1881917 1772068 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1667699 1667699 1580992 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22528563 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2047814 2047814 1928086 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24197981 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1672444 1672444 1585498 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21729655 surgery-fixed primary 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1498646 1498646 1421524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21315472 surgery - NOS metastasis 57 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1635374 1635374 1551879 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22335887 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1637158 1637158 1553206 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22321543 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1705467 1705467 1613373 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22707299 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2422943 2422943 2285865 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25450875 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2163046 2163046 2031630 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24810493 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421160 2421160 2284082 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218675 2218675 2086668 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSM28574 178384302 c.? p.P848L Substitution - Missense + - Reported in another cancer sample as somatic 25078331 surgery-fixed metastasis 64 ENSP00000275493.2:p.Pro848Leu EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2665553 2665553 2525262 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51789625 COSM13197 133204854 c.2455G>A p.A819T Substitution - Missense 38 7:55191839-55191839 + - PATHOGENIC .9615 Confirmed somatic variant 28984303 surgery-fixed NS ENSP00000415559.1:p.Ala819Thr ENST00000455089.5:c.2455G>A 7:g.55191839G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812087 2812087 2668553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51823614 COSM4170219 133202511 c.2120C>T p.S707F Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98332 Confirmed somatic variant 31534501 circulating tumour NS 76 ENSP00000415559.1:p.Ser707Phe ENST00000455089.5:c.2120C>T 7:g.55174792C>T EGFR ENST00000275493.6 3633 3236 1043130 1043130 959471 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51778659 COSM14070 99374271 c.2588G>A p.G863D Substitution - Missense 38 7:55191837-55191837 + - PATHOGENIC .92688 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 51 ENSP00000275493.2:p.Gly863Asp ENST00000275493.6:c.2588G>A 7:g.55191837G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0012113-T01-IM5 2727253 2586074 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51851189 COSM6982714 133218903 c.1270T>G p.L424V Substitution - Missense het 38 7:55160245-55160245 + - NEUTRAL .32338 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu424Val ENST00000455089.5:c.1270T>G 7:g.55160245T>G EGFR ENST00000275493.6 3633 3236 2422465 2422465 2285387 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 25521406 surgery - NOS metastasis 56 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2566146 2566146 2427537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 27794398 surgery-fixed NS 74 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2009157 2009157 1891891 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136867 1136867 1049431 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1047005 1047005 963236 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897839 897839 815461 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862726 2862726 2717889 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1931645 1931645 1818935 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1549838 1549838 1471943 lung right_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21830212 surgery - NOS NS 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 7 1433972 1343387 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20502057 surgery-fixed NS 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897842 897842 815464 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1067074 1067074 983054 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983749 1983749 1869985 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2147916 2147916 2017059 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24722155 surgery-fixed metastasis 55 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891216 1891216 1780585 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2156367 2156367 2025375 lung left_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24752053 surgery - NOS metastasis 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899313 899313 816925 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1931638 1931638 1818928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 946823 946823 863346 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16204011 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983780 1983780 1870016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 V153 1179732 1091694 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891273 1891273 1780642 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136872 1136872 1049436 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895098 1895098 1783790 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1523074 1523074 1445446 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 41 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879495 1879495 1769997 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2156367 2156367 2025375 lung left_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 24752053 surgery - NOS metastasis 70 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2659794 2659794 2519952 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2585421 2585421 2446585 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576891 COSM9396331 99390041 c.1400A>C p.K467T Substitution - Missense het 38 7:55160240-55160240 + - NEUTRAL .10442 Reported in another cancer sample as somatic 25623215 surgery - NOS recurrent ENSP00000275493.2:p.Lys467Thr ENST00000275493.6:c.1400A>C 7:g.55160240A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MSU2-a 2809971 2666633 large_intestine caecum NS NS adenoma villous NS NS y COSV51784286 COSM6652281 132555792 c.116C>T p.T39M Substitution - Missense 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000395243.3:p.Thr39Met ENST00000454757.6:c.116C>T 7:g.55142313C>T EGFR ENST00000275493.6 3633 3236 1931647 1931647 1818937 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 23621221 NS primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1593027 1593027 1513953 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-14-0813-01 1337991 1248376 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779162 COSM21689 132548259 c.1652C>T p.P551L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 329 surgery fresh/frozen NS 78 ENSP00000395243.3:p.Pro551Leu ENST00000454757.6:c.1652C>T 7:g.55165344C>T EGFR ENST00000275493.6 3633 3236 2008798 2008798 1891532 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 23961259 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1513411 1513411 1436072 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 21497370 fixed - NOS metastasis ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2566146 2566146 2427537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Reported in another cancer sample as somatic 27794398 surgery-fixed NS 74 ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 PD_06 2688647 2547629 skin face NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51852113 COSM4501266 99392071 c.584C>T p.P195L Substitution - Missense het 38 7:55151318-55151318 + - NEUTRAL .31382 Confirmed somatic variant 24662767 surgery fresh/frozen NS 75 ENSP00000275493.2:p.Pro195Leu ENST00000275493.6:c.584C>T 7:g.55151318C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811936 2811936 2668488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed metastasis 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 400_R4 2910227 2764189 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV104577128 COSM9497116 132601764 c.1336A>G p.I446V Substitution - Missense het 38 7:55160311-55160311 + - NEUTRAL .12941 Confirmed somatic variant 27639803 short-term culture NS 69 ENSP00000395243.3:p.Ile446Val ENST00000454757.6:c.1336A>G 7:g.55160311A>G EGFR ENST00000275493.6 3633 3236 2625552 2625552 2485964 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 71 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005012 1005012 922224 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1089141 1089141 1004095 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17904685 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1558205 1558205 1479576 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21835826 surgery - NOS metastasis 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895110 1895110 1783802 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891177 1891177 1780546 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2009147 2009147 1891881 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23979199 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891338 1891338 1780707 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899304 899304 816916 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 907087 907087 824599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 ESCC_35 2479543 2342303 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51774192 COSM5628704 132587003 c.461G>C p.C154S Substitution - Missense 38 7:55151330-55151330 + - PATHOGENIC .99573 Confirmed somatic variant 26873401 NS NS 68 ENSP00000395243.3:p.Cys154Ser ENST00000454757.6:c.461G>C 7:g.55151330G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1896424 1896424 1785116 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 23540867 surgery - NOS NS 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2046174 2046174 1926469 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 899311 899311 816923 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920154 920154 837234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 49 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226917 2226917 2094652 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1075910 1075910 991164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453424 1453424 1377457 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 V141 1179746 1091708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19096301 surgery fresh/frozen primary 76 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1042914 1042914 959255 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17285735 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2625559 2625559 2485971 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 27056568 surgery-fixed NS 51 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1668458 1668458 1581751 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453425 1453425 1377458 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 ABC-1 946050 862576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16105816 cell-line NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302270 1302270 1213321 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1517070 1517070 1439664 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 47 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1077338 1077338 992592 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16199108 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453435 1453435 1377468 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20559149 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-14-0813-01 1337991 1248376 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779162 COSM21689 133203297 c.1652C>T p.P551L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 329 surgery fresh/frozen NS 78 ENSP00000415559.1:p.Pro551Leu ENST00000455089.5:c.1652C>T 7:g.55165344C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458696 1458696 1382671 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891338 1891338 1780707 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1992091 1992091 1877408 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow recurrent 59 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1075910 1075910 991164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1043128 1043128 959469 upper_aerodigestive_tract mouth tongue NS carcinoma squamous_cell_carcinoma NS NS n COSV51782403 COSM22951 99416657 c.2384T>C p.F795S Substitution - Missense 38 7:55181393-55181393 + - .67484 Reported in another cancer sample as somatic 17224267 surgery-fixed NS 76 ENSP00000275493.2:p.Phe795Ser ENST00000275493.6:c.2384T>C 7:g.55181393T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811936 2811936 2668488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed metastasis 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 400_R4 2910227 2764189 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV104577128 COSM9497116 133265950 c.1336A>G p.I446V Substitution - Missense het 38 7:55160311-55160311 + - NEUTRAL .12941 Confirmed somatic variant 27639803 short-term culture NS 69 ENSP00000415559.1:p.Ile446Val ENST00000455089.5:c.1336A>G 7:g.55160311A>G EGFR ENST00000275493.6 3633 3236 1024D 2605257 2466148 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM34166 178380439 c.? p.R108K Substitution - Missense + - Reported in another cancer sample as somatic 25376516 surgery - NOS NS 70 ENSP00000275493.2:p.Arg108Lys EGFR ENST00000275493.6 3633 3236 CSCC-40-T 2292477 2158541 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51858853 COSM4512041 99436396 c.889C>T p.R297C Substitution - Missense het 38 7:55154152-55154152 + - PATHOGENIC .97012 Confirmed somatic variant 25303977 surgery fresh/frozen metastasis 49 ENSP00000275493.2:p.Arg297Cys ENST00000275493.6:c.889C>T 7:g.55154152C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005012 1005012 922224 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1896424 1896424 1785116 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 23540867 surgery - NOS NS 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1487002 1487002 1410620 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51803719 COSM53291 132550364 c.2350G>A p.E784K Substitution - Missense 38 7:55191734-55191734 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 65 ENSP00000395243.3:p.Glu784Lys ENST00000454757.6:c.2350G>A 7:g.55191734G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 ESCC_35 2479543 2342303 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51774192 COSM5628704 133248640 c.461G>C p.C154S Substitution - Missense 38 7:55151330-55151330 + - PATHOGENIC .99573 Confirmed somatic variant 26873401 NS NS 68 ENSP00000415559.1:p.Cys154Ser ENST00000455089.5:c.461G>C 7:g.55151330G>C EGFR ENST00000275493.6 3633 3236 2667796 2667796 2527458 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSM6843698 178388877 c.? p.A289D Substitution - Missense + - Reported in another cancer sample as somatic 28663030 surgery-fixed NS ENSP00000275493.2:p.Ala289Asp EGFR ENST00000275493.6 3633 3236 2732923 2732923 2591676 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 64 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458696 1458696 1382671 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 19 2570191 2431488 skin face NS NS adnexal_tumour other sebaceoma NS n COSV51794784 COSM13182 99375617 c.2203G>A p.G735S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 71 ENSP00000275493.2:p.Gly735Ser ENST00000275493.6:c.2203G>A 7:g.55174740G>A EGFR ENST00000275493.6 3633 3236 2319464 2319464 2184621 central_nervous_system brain NS NS glioma NS NS NS n COSM34166 178380439 c.? p.R108K Substitution - Missense + - Reported in another cancer sample as somatic 25529192 surgery - NOS NS ENSP00000275493.2:p.Arg108Lys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GB057T 2634022 2494418 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 672 NS primary ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A HTR3E_ENST00000436361 ENST00000436361.6 1371 24005 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105899663 COSM10012911 129077226 c.508C>A p.P170T Substitution - Missense 38 3:184104905-184104905 + - PATHOGENIC .98714 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000395833.2:p.Pro170Thr ENST00000436361.6:c.508C>A 3:g.184104905C>A EGFR ENST00000275493.6 3633 3236 2824227 2824227 2680045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM5010368 178378709 c.? p.C797S Substitution - Missense + Yes Reported in another cancer sample as somatic 31542322 circulating tumour recurrent 62 ENSP00000275493.2:p.Cys797Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1487002 1487002 1410620 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51803719 COSM53291 133205251 c.2350G>A p.E784K Substitution - Missense 38 7:55191734-55191734 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 65 ENSP00000415559.1:p.Glu784Lys ENST00000455089.5:c.2350G>A 7:g.55191734G>A EGFR ENST00000275493.6 3633 3236 19 2570191 2431488 skin face NS NS adnexal_tumour other sebaceoma NS n COSV51771864 COSM6226 99383011 c.2326C>T p.R776C Substitution - Missense 38 7:55181335-55181335 + - PATHOGENIC .97187 Reported in another cancer sample as somatic 27311873 surgery-fixed NS 71 ENSP00000275493.2:p.Arg776Cys ENST00000275493.6:c.2326C>T 7:g.55181335C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 ESCC-D3 2394863 2257694 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51854767 COSM5046159 132569525 c.2425A>C p.T809P Substitution - Missense 38 7:55191809-55191809 + - PATHOGENIC .98739 Confirmed somatic variant 24686850 NS NS 66 ENSP00000395243.3:p.Thr809Pro ENST00000454757.6:c.2425A>C 7:g.55191809A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FG-6692-01 2194411 2062689 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 63 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1103796 1103796 1018048 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-DU-7012-01 2194261 2062539 central_nervous_system brain NS NS glioma NS NS NS y COSV51774829 COSM1451549 99376761 c.767A>G p.D256G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 545 NS NS 74 ENSP00000275493.2:p.Asp256Gly ENST00000275493.6:c.767A>G 7:g.55154030A>G EGFR ENST00000275493.6 3633 3236 1450865 1450865 1375008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 77 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1860431 1860431 1751372 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23327870 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1202560 1202560 1114446 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897781 897781 815403 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1594599 1594599 1515567 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19724844 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2659809 2659809 2519967 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 28744312 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899341 899341 816953 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1592992 1592992 1513918 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1166444 1166444 1078758 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1593018 1593018 1513944 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1429296 1429296 1338747 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20512074 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302276 1302276 1213327 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 DCR9 1690658 1598935 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 99388924 c.1476C>A p.S492R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000275493.2:p.Ser492Arg ENST00000275493.6:c.1476C>A 7:g.55160316C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GB057T 2634022 2494418 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 672 NS primary ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 non-ocular_carcinoma_3 2580640 2441977 skin neck NS NS adnexal_tumour sebaceous_carcinoma NS NS n COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 27287813 surgery-fixed primary ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1505363 1505363 1428241 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51797168 COSM87247 132576297 c.2452G>A p.G818S Substitution - Missense 38 7:55191836-55191836 + - PATHOGENIC .94673 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000395243.3:p.Gly818Ser ENST00000454757.6:c.2452G>A 7:g.55191836G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 6360 915996 833395 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899305 899305 816917 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1047001 1047001 963232 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17233841 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920131 920131 837211 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15958609 surgery - NOS primary 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1738958 1738958 1644789 breast NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22538770 fine needle aspirate NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875359 1875359 1765942 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453492 1453492 1377525 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1593019 1593019 1513945 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21057810 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136891 1136891 1049455 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2156365 2156365 2025374 lung left_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24752053 surgery - NOS primary 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226906 2226906 2094641 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1136874 1136874 1049438 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17580276 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983763 1983763 1869999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1816946 1816946 1716114 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1522944 1522944 1445316 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 21635547 surgery-fixed primary 63 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2226875 2226875 2094610 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1500588 1500588 1423467 stomach NS NS NS carcinoma mucinous_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21436633 surgery - NOS NS 76 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1450849 1450849 1374992 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20491778 surgery fresh/frozen NS 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 899315 899315 816927 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15741570 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897835 897835 815457 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1067067 1067067 983047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1751707 1751707 1656523 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22901298 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1884153 1884153 1774040 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23491080 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1714997 1714997 1622576 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22710815 surgery-fixed primary 77 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1110467 1110467 1024345 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897831 897831 815453 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1075923 1075923 991177 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17561305 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1891254 1891254 1780623 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23371856 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1202561 1202561 1114447 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19362747 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-S3-A6ZG-01 2187686 2055964 breast NS NS NS carcinoma NS NS NS y COSV99287475 COSM7699858 132558965 c.2648A>T p.E883V Substitution - Missense 38 7:55198798-55198798 + - PATHOGENIC .98866 Confirmed somatic variant 414 NS NS 71 ENSP00000395243.3:p.Glu883Val ENST00000454757.6:c.2648A>T 7:g.55198798A>T EGFR ENST00000275493.6 3633 3236 A017-T-S20 2757378 2615994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 56 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862717 2862717 2717880 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1110460 1110460 1024338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18403609 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1875371 1875371 1765954 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22847157 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1479934 1479934 1403594 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21151896 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005008 1005008 922220 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1517067 1517067 1439661 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21592614 surgery-fixed NS 59 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1625785 1625785 1543009 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1625784 1625784 1543008 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22117119 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1648545 1648545 1563500 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21532509 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226866 2226866 2094601 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1453498 1453498 1377531 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20498546 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2226900 2226900 2094635 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1990903 1990903 1876238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23852459 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2396138 2396138 2258969 lung left_bronchus NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 24942894 fine needle aspirate primary 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1302287 1302287 1213338 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19963121 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 BL-18-K32111 2905107 2759363 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983746 1983746 1869982 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1981033 1981033 1867269 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 S25 1063224 979269 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17473653 surgery fresh/frozen primary 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1305391 1305391 1216439 lung NS NS NS carcinoma oncocytic_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20023269 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983745 1983745 1869981 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-44-A4SU-01 2194780 2063058 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 417 NS NS 67 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-44-A4SU-01 2194780 2063058 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 417 NS NS 67 ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1576791 1576791 1498232 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 21921847 blood-bone marrow recurrent 56 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2819306 2819306 2675605 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 30711944 surgery - NOS recurrent 79 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2819289 2819289 2675588 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 30711944 pleural effusion recurrent 66 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2819294 2819294 2675593 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 30711944 surgery - NOS NS 63 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879489 1879489 1769991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1024766 1024766 941743 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 17020982 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1992094 1992094 1877411 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23886554 blood-bone marrow NS 75 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0000165-T01-IM3 2714735 2573556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 ESCC-D3 2394863 2257694 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51854767 COSM5046159 133226876 c.2425A>C p.T809P Substitution - Missense 38 7:55191809-55191809 + - PATHOGENIC .98739 Confirmed somatic variant 24686850 NS NS 66 ENSP00000415559.1:p.Thr809Pro ENST00000455089.5:c.2425A>C 7:g.55191809A>C EGFR ENST00000275493.6 3633 3236 P-0002296-T01-IM3 2782972 2640755 prostate NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51800946 COSM6921640 99384175 c.2279T>C p.L760P Substitution - Missense het 38 7:55174816-55174816 + - PATHOGENIC .99068 Confirmed somatic variant 28825054 surgery-fixed metastasis 55 ENSP00000275493.2:p.Leu760Pro ENST00000275493.6:c.2279T>C 7:g.55174816T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FG-6692-01 2194411 2062689 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 63 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 non-ocular_carcinoma_3 2580640 2441977 skin neck NS NS adnexal_tumour sebaceous_carcinoma NS NS n COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 27287813 surgery-fixed primary ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1505363 1505363 1428241 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51797168 COSM87247 133235835 c.2452G>A p.G818S Substitution - Missense 38 7:55191836-55191836 + - PATHOGENIC .94673 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000415559.1:p.Gly818Ser ENST00000455089.5:c.2452G>A 7:g.55191836G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 6360 915996 833395 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-S3-A6ZG-01 2187686 2055964 breast NS NS NS carcinoma NS NS NS y COSV99287475 COSM7699858 133215117 c.2648A>T p.E883V Substitution - Missense 38 7:55198798-55198798 + - PATHOGENIC .98866 Confirmed somatic variant 414 NS NS 71 ENSP00000415559.1:p.Glu883Val ENST00000455089.5:c.2648A>T 7:g.55198798A>T EGFR ENST00000275493.6 3633 3236 2115509 2115509 1989753 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-44-A4SU-01 2194780 2063058 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 417 NS NS 67 ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-44-A4SU-01 2194780 2063058 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 417 NS NS 67 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DU-6407-02 2185941 2054238 central_nervous_system brain NS NS glioma NS NS NS y COSV51859563 COSM6910210 132549516 c.2374G>A p.D792N Substitution - Missense 38 7:55191758-55191758 + - PATHOGENIC .98912 Confirmed somatic variant 545 NS NS 35 ENSP00000395243.3:p.Asp792Asn ENST00000454757.6:c.2374G>A 7:g.55191758G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005008 1005008 922220 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001251 1001251 918474 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003752-T02-IM5 2720241 2579062 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982880 982880 898599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LC_S5 1863765 1754656 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 79 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1998743 1998743 1883815 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23937608 surgery-fixed primary 58 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1966333 1966333 1852826 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23787800 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2238949 2238949 2106481 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25137181 blood-bone marrow NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1914964 1914964 1802966 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 23590575 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1715968 1715968 1623530 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 22760226 surgery - NOS recurrent 69 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2345056 2345056 2209728 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu861Gln HMGB1_ENST00000405805 ENST00000405805.5 648 4983 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV58104601 COSM3813701 121744158 c.630A>T p.E210D Substitution - Missense 38 13:30461375-30461375 - - .57857 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000384678.1:p.Glu210Asp ENST00000405805.5:c.630A>T 13:g.30461375T>A SEZ6_ENST00000335960 ENST00000335960.10 2985 15955 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105887926 COSM10012920 104638346 c.1904T>C p.I635T Substitution - Missense 38 17:28959340-28959340 - - PATHOGENIC .9935 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000337407.7:p.Ile635Thr ENST00000335960.10:c.1904T>C 17:g.28959340A>G EGFR ENST00000275493.6 3633 3236 1098818 1098818 1013410 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51848710 COSM26438 99389356 c.2620G>A p.G874S Substitution - Missense 38 7:55191869-55191869 + - PATHOGENIC .98912 Reported in another cancer sample as somatic 18176089 surgery fresh/frozen primary 50 ENSP00000275493.2:p.Gly874Ser ENST00000275493.6:c.2620G>A 7:g.55191869G>A EGFR ENST00000275493.6 3633 3236 1194738 1194738 1106633 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001251 1001251 918474 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DU-6407-02 2185941 2054238 central_nervous_system brain NS NS glioma NS NS NS y COSV51859563 COSM6910210 133204470 c.2374G>A p.D792N Substitution - Missense 38 7:55191758-55191758 + - PATHOGENIC .98912 Confirmed somatic variant 545 NS NS 35 ENSP00000415559.1:p.Asp792Asn ENST00000455089.5:c.2374G>A 7:g.55191758G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003752-T02-IM5 2720241 2579062 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2841184 2841184 2696744 prostate NS NS NS carcinoma NS NS NS n COSV104577128 COSM9497116 99442635 c.1471A>G p.I491V Substitution - Missense 38 7:55160311-55160311 + - NEUTRAL .12941 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000275493.2:p.Ile491Val ENST00000275493.6:c.1471A>G 7:g.55160311A>G EGFR ENST00000275493.6 3633 3236 426 2267398 2134166 oesophagus middle_third NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51819303 COSM4432960 99402727 c.2744A>G p.Y915C Substitution - Missense 38 7:55198759-55198759 + - PATHOGENIC .97948 Confirmed somatic variant 25151357 surgery fresh/frozen primary 57 ENSP00000275493.2:p.Tyr915Cys ENST00000275493.6:c.2744A>G 7:g.55198759A>G EGFR ENST00000275493.6 3633 3236 112509 1520625 1443000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51833788 COSM94181 99434788 c.1675C>T p.H559Y Substitution - Missense 38 7:55163776-55163776 + - PATHOGENIC .97598 Confirmed somatic variant 20668451 NS primary ENSP00000275493.2:p.His559Tyr ENST00000275493.6:c.1675C>T 7:g.55163776C>T EGFR ENST00000275493.6 3633 3236 P-0002054-T01-IM3 2718359 2577180 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51839619 COSM6920482 99393748 c.2863G>A p.A955T Substitution - Missense het 38 7:55200330-55200330 + - PATHOGENIC .99154 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ala955Thr ENST00000275493.6:c.2863G>A 7:g.55200330G>A EGFR ENST00000275493.6 3633 3236 1965914 1965914 1852407 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1481254 1481254 1404883 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 21233402 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 3C 2529057 2390913 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 27304188 pleural effusion recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746676 1746676 1651652 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1746651 1746651 1651627 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 59 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2426829 2426829 2289750 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent 33 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1469855 1469855 1393594 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618758 1618758 1537510 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 54 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1635869 1635869 1551973 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 22228822 surgery - NOS metastasis 44 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1237705 1237705 1149452 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2096282 2096282 1974346 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1618623 1618623 1537375 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 85 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2665708 2665708 2525417 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Reported in another cancer sample as somatic 28978102 surgery - NOS recurrent 67 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-16-1045-01 1338027 1248412 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 132551880 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 surgery fresh/frozen NS 49 ENSP00000395243.3:p.Thr218Pro ENST00000454757.6:c.652A>C 7:g.55154050A>C EGFR ENST00000275493.6 3633 3236 2096255 2096255 1974319 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2095985 2095985 1974049 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141275 1141275 1053723 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2000173 2000173 1885071 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23945384 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2105813 2105813 1983851 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24303521 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1475400 1475400 1399099 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21111508 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468896 1468896 1392635 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21128242 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1964317 1964317 1850852 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23749122 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2421203 2421203 2284125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25605150 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1036703 1036703 953460 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 17106442 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1547814 1547814 1469936 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21430269 surgery-fixed recurrent 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2157001 2157001 2025976 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24828666 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2033587 2033587 1915036 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24137397 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551534 1551534 1473639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469408 1469408 1393147 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1746651 1746651 1651627 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22899358 surgery fresh/frozen primary 59 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2078477 2078477 1957196 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24378285 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777226 1777226 1681229 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2148579 2148579 2017709 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24700479 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770600 1770600 1674840 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1994273 1994273 1879528 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23886169 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246659 1246659 1158338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2238949 2238949 2106481 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25137181 blood-bone marrow NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2026221 2026221 1908310 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24040454 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469855 1469855 1393594 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21135146 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1618758 1618758 1537510 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 22215752 surgery-fixed NS 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2637696 2637696 2498069 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28104619 circulating tumour recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469441 1469441 1393180 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1237705 1237705 1149452 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19609951 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2425724 2425724 2288645 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23724098 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1107788 1107788 1021691 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18283321 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1551545 1551545 1473650 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21858063 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2069197 2069197 1948772 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24346091 NS metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1885182 1885182 1775069 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23439505 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 925039 925039 841812 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16133419 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770567 1770567 1674807 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1515264 1515264 1437874 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21524465 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770640 1770640 1674880 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1097644 1097644 1012305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18172267 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096154 2096154 1974218 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345547 2345547 2210219 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1887419 1887419 1777091 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23536868 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1246682 1246682 1158361 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19692680 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1965829 1965829 1852322 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23726438 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1881922 1881922 1772073 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23341890 surgery fresh/frozen primary 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1223895 1223895 1135727 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19517135 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345516 2345516 2210188 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2083092 2083092 1961513 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24300726 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1777344 1777344 1681347 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23036155 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1465885 1465885 1389732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20808254 NS NS 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1937520 1937520 1824454 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23645738 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2680489 2680489 2539762 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 27998968 surgery-fixed NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2250000 2250000 2117259 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24646139 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345463 2345463 2210135 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770523 1770523 1674763 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469455 1469455 1393194 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1179116 1179116 1091078 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 19185949 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1459524 1459524 1383467 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20637128 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770668 1770668 1674908 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2218524 2218524 2086535 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25098700 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1444733 1444733 1368976 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 20548248 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141332 1141332 1053780 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2349273 2349273 2213665 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25654374 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469485 1469485 1393224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1141306 1141306 1053754 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 18794545 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2095958 2095958 1974022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345406 2345406 2210078 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1835499 1835499 1730531 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23242440 NS NS 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1469461 1469461 1393200 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21129809 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2081824 2081824 1960246 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24481317 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1479104 1479104 1402797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 21167064 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345500 2345500 2210172 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2028998 2028998 1910880 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Reported in another cancer sample as somatic 23628817 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2096009 2096009 1974073 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24419411 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2226161 2226161 2093896 lung NS NS NS carcinoma NS NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24924582 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2665708 2665708 2525417 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 28978102 surgery - NOS recurrent 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2046029 2046029 1926324 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 24179496 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2345484 2345484 2210156 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 25668120 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 983154 983154 898872 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 16552419 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1770591 1770591 1674831 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Reported in another cancer sample as somatic 23014527 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 GBM19-I1 2813465 2669857 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 2638654 2638654 2499027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 28572531 circulating tumour primary 56 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GCYC_110_T 2747564 2606267 stomach NS NS NS carcinoma NS NS NS y COSV99293603 COSM8524528 132619891 c.3057C>A p.S1019R Substitution - Missense 38 7:55202546-55202546 + - PATHOGENIC .94645 Confirmed somatic variant 683 NS primary ENSP00000395243.3:p.Ser1019Arg ENST00000454757.6:c.3057C>A 7:g.55202546C>A EGFR ENST00000275493.6 3633 3236 1004995 1004995 922207 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-12-1600-01 2178073 2046371 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 329 NS NS 86 ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DF-A2L0-01 2457392 2320229 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51809160 COSM382935 132551562 c.1471G>A p.V491M Substitution - Missense 38 7:55161606-55161606 + - PATHOGENIC .98051 Confirmed somatic variant 419 NS primary 60 ENSP00000395243.3:p.Val491Met ENST00000454757.6:c.1471G>A 7:g.55161606G>A EGFR ENST00000275493.6 3633 3236 S004384 1027694 944670 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T NEU3_ENST00000531509 ENST00000531509.5 1386 7760 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105876930 COSM10012896 150633336 c.520G>T p.V174L Substitution - Missense 38 11:75005626-75005626 + - NEUTRAL .3053 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000432097.1:p.Val174Leu ENST00000531509.5:c.520G>T 11:g.75005626G>T EGFR ENST00000275493.6 3633 3236 LPS22 2800436 2657252 soft_tissue fat NS NS liposarcoma myxoid-round_cell NS NS y COSV99287159 COSM9110953 99454535 c.3566G>A p.G1189D Substitution - Missense 38 7:55205550-55205550 + - PATHOGENIC .90278 Confirmed somatic variant 26643872 surgery - NOS primary 48 ENSP00000275493.2:p.Gly1189Asp ENST00000275493.6:c.3566G>A 7:g.55205550G>A EGFR ENST00000275493.6 3633 3236 GB013T 2633978 2494374 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51855854 COSM6355744 99417542 c.977G>T p.C326F Substitution - Missense 38 7:55155917-55155917 + - PATHOGENIC .99445 Confirmed somatic variant 672 NS primary ENSP00000275493.2:p.Cys326Phe ENST00000275493.6:c.977G>T 7:g.55155917G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007870-T01-IM5 2724083 2582904 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-D5-6928-01 1651267 1566054 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51794983 COSM1451619 99431548 c.3287C>T p.S1096F Substitution - Missense 38 7:55205271-55205271 + - NEUTRAL .09807 Confirmed somatic variant 376 NS NS 80 ENSP00000275493.2:p.Ser1096Phe ENST00000275493.6:c.3287C>T 7:g.55205271C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1031892 1031892 948683 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17085664 NS primary 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471548 1471548 1395287 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 U373 2491105 2353751 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51804471 COSM5712404 99459433 c.1523C>T p.A508V Substitution - Missense 38 7:55161523-55161523 + - NEUTRAL .21884 Confirmed somatic variant 26496030 cell-line NS ENSP00000275493.2:p.Ala508Val ENST00000275493.6:c.1523C>T 7:g.55161523C>T EGFR ENST00000275493.6 3633 3236 GBM13-I3 2813477 2669869 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28263318 surgery fresh/frozen NS 55 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 897851 897851 815473 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 P-0007024-T01-IM5 2723398 2582219 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 P-0007024-T01-IM5 2723398 2582219 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51786507 COSM6955643 99414780 c.1118C>T p.P373L Substitution - Missense het 38 7:55156644-55156644 + - PATHOGENIC .86501 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Pro373Leu ENST00000275493.6:c.1118C>T 7:g.55156644C>T EGFR ENST00000275493.6 3633 3236 2862464 2862464 2717627 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 31694833 circulating tumour NS 33 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002124-T01-IM3 2718419 2577240 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51806564 COSM6920868 132555861 c.1871G>A p.R624Q Substitution - Missense het 38 7:55173069-55173069 + - PATHOGENIC .99699 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Arg624Gln ENST00000454757.6:c.1871G>A 7:g.55173069G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876663 2876663 2731178 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 surgery fresh/frozen NS 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876663 2876663 2731178 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 surgery fresh/frozen NS 60 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 TCGA-AP-A051-01 1783330 1687329 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51837186 COSM1090861 99388940 c.442G>A p.V148M Substitution - Missense het 38 7:55146623-55146623 + - PATHOGENIC .99004 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 69 ENSP00000275493.2:p.Val148Met ENST00000275493.6:c.442G>A 7:g.55146623G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206733 1206733 1118611 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51837705 COSM29577 132563747 c.2428G>A p.D810N Substitution - Missense 38 7:55191812-55191812 + - PATHOGENIC .98898 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Asp810Asn ENST00000454757.6:c.2428G>A 7:g.55191812G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206733 1206733 1118611 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51796944 COSM28537 132554913 c.2425A>G p.T809A Substitution - Missense 38 7:55191809-55191809 + - PATHOGENIC .9858 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Thr809Ala ENST00000454757.6:c.2425A>G 7:g.55191809A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005393-T01-IM5 2721796 2580617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 447 898389 816001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1312392 1312392 1223301 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 59 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-05-4402-01 1780061 1684060 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51795112 COSM23633 132573436 c.2141T>A p.I714N Substitution - Missense 38 7:55174813-55174813 + - PATHOGENIC .99182 Confirmed somatic variant 417 fresh/frozen - NOS primary 57 ENSP00000395243.3:p.Ile714Asn ENST00000454757.6:c.2141T>A 7:g.55174813T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-16-1045-01 1338027 1248412 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 133206822 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 surgery fresh/frozen NS 49 ENSP00000415559.1:p.Thr218Pro ENST00000455089.5:c.652A>C 7:g.55154050A>C EGFR ENST00000275493.6 3633 3236 5-VS033-T2 2869855 2724852 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51790737 COSM3639739 99437856 c.1621C>T p.L541F Substitution - Missense 38 7:55161621-55161621 + - NEUTRAL .0484 Confirmed somatic variant 26950094 surgery - NOS NS 73 ENSP00000275493.2:p.Leu541Phe ENST00000275493.6:c.1621C>T 7:g.55161621C>T EGFR ENST00000275493.6 3633 3236 2115529 2115529 1989773 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 NPC0001PT00407T00407 2857330 2712630 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 5-VS033-T2 2869855 2724852 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51776559 COSM4892884 99381163 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 26950094 surgery - NOS NS 73 ENSP00000275493.2:p.Pro100Ser ENST00000275493.6:c.298C>T 7:g.55143362C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000677-T01-IM3 2715765 2574586 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51860516 COSM6911906 132569604 c.1008C>G p.F336L Substitution - Missense het 38 7:55156768-55156768 + - PATHOGENIC .96387 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Phe336Leu ENST00000454757.6:c.1008C>G 7:g.55156768C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489262 1489262 1412420 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 907083 907083 824595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Reported in another cancer sample as somatic 15710947 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GCYC_110_T 2747564 2606267 stomach NS NS NS carcinoma NS NS NS y COSV99293603 COSM8524528 133283100 c.3057C>A p.S1019R Substitution - Missense 38 7:55202546-55202546 + - PATHOGENIC .94645 Confirmed somatic variant 683 NS primary ENSP00000415559.1:p.Ser1019Arg ENST00000455089.5:c.3057C>A 7:g.55202546C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DF-A2L0-01 2457392 2320229 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51809160 COSM382935 133206494 c.1471G>A p.V491M Substitution - Missense 38 7:55161606-55161606 + - PATHOGENIC .98051 Confirmed somatic variant 419 NS primary 60 ENSP00000415559.1:p.Val491Met ENST00000455089.5:c.1471G>A 7:g.55161606G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1063626 1063626 979671 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 45 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152781 2152781 2021791 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007870-T01-IM5 2724083 2582904 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471548 1471548 1395287 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1031892 1031892 948683 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17085664 NS primary 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-HC-7075-01 2121474 1995710 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51805358 COSM3674958 99429443 c.1954G>T p.G652W Substitution - Missense 38 7:55173017-55173017 + - PATHOGENIC .99788 Confirmed somatic variant 435 NS NS 63 ENSP00000275493.2:p.Gly652Trp ENST00000275493.6:c.1954G>T 7:g.55173017G>T EGFR ENST00000275493.6 3633 3236 1471807 1471807 1395545 ovary NS NS NS carcinoma adenocarcinoma NS NS n COSV51780206 COSM12373 99380273 c.2159C>T p.S720F Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .9768 Reported in another cancer sample as somatic 21057220 surgery-fixed primary ENSP00000275493.2:p.Ser720Phe ENST00000275493.6:c.2159C>T 7:g.55174018C>T EGFR ENST00000275493.6 3633 3236 2226909 2226909 2094644 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 24891042 NS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 982777 982777 898496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Reported in another cancer sample as somatic 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002124-T01-IM3 2718419 2577240 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51806564 COSM6920868 133211798 c.1871G>A p.R624Q Substitution - Missense het 38 7:55173069-55173069 + - PATHOGENIC .99699 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Arg624Gln ENST00000455089.5:c.1871G>A 7:g.55173069G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 ICGC_GBM53_tumor 2634861 2495257 central_nervous_system brain NS NS primitive_neuroectodermal_tumour-medulloblastoma NS NS NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 379 NS primary 5 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876663 2876663 2731178 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 surgery fresh/frozen NS 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876663 2876663 2731178 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 surgery fresh/frozen NS 60 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 5 1489412 1412570 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21102258 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206733 1206733 1118611 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51837705 COSM29577 133220093 c.2428G>A p.D810N Substitution - Missense 38 7:55191812-55191812 + - PATHOGENIC .98898 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Asp810Asn ENST00000455089.5:c.2428G>A 7:g.55191812G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206733 1206733 1118611 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51796944 COSM28537 133210567 c.2425A>G p.T809A Substitution - Missense 38 7:55191809-55191809 + - PATHOGENIC .9858 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Thr809Ala ENST00000455089.5:c.2425A>G 7:g.55191809A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005393-T01-IM5 2721796 2580617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 447 898389 816001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-05-4402-01 1780061 1684060 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51795112 COSM23633 133231506 c.2141T>A p.I714N Substitution - Missense 38 7:55174813-55174813 + - PATHOGENIC .99182 Confirmed somatic variant 417 fresh/frozen - NOS primary 57 ENSP00000415559.1:p.Ile714Asn ENST00000455089.5:c.2141T>A 7:g.55174813T>A EGFR ENST00000275493.6 3633 3236 2477015 2477015 2339784 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25355724 NS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 1135338 1135338 1047904 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 17591931 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 2862197 2862197 2717393 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Reported in another cancer sample as somatic 25969368 surgery-fixed primary ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000454757 ENST00000454757.6 3498 3236 ESCC_96 2479594 2342354 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51783269 COSM5637701 132575989 c.2659C>A p.R887S Substitution - Missense 38 7:55198809-55198809 + - PATHOGENIC .92422 Confirmed somatic variant 26873401 NS NS 66 ENSP00000395243.3:p.Arg887Ser ENST00000454757.6:c.2659C>A 7:g.55198809C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876061 2876061 2730576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 77 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0005123-T01-IM5 2721527 2580348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 NS metastasis ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2901981 2901981 2756227 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2901981 2901981 2756227 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Leu861Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EB-A44P-01 2121603 1995839 skin NS NS NS malignant_melanoma NS NS NS y COSV51857489 COSM3639760 132589848 c.3398C>T p.P1133L Substitution - Missense 38 7:55205517-55205517 + - PATHOGENIC .96485 Confirmed somatic variant 540 NS NS 58 ENSP00000395243.3:p.Pro1133Leu ENST00000454757.6:c.3398C>T 7:g.55205517C>T EGFR ENST00000275493.6 3633 3236 1004984 1004984 922196 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000677-T01-IM3 2715765 2574586 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51860516 COSM6911906 133226987 c.1008C>G p.F336L Substitution - Missense het 38 7:55156768-55156768 + - PATHOGENIC .96387 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Phe336Leu ENST00000455089.5:c.1008C>G 7:g.55156768C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489262 1489262 1412420 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 GB051T 2634016 2494412 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51846120 COSM6354678 99449636 c.1973T>A p.L658Q Substitution - Missense 38 7:55173036-55173036 + - PATHOGENIC .99616 Confirmed somatic variant 672 NS primary ENSP00000275493.2:p.Leu658Gln ENST00000275493.6:c.1973T>A 7:g.55173036T>A EGFR ENST00000275493.6 3633 3236 GB051T 2634016 2494412 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51846086 COSM6354719 99449611 c.178G>A p.V60M Substitution - Missense 38 7:55142375-55142375 + - PATHOGENIC .96004 Confirmed somatic variant 672 NS primary ENSP00000275493.2:p.Val60Met ENST00000275493.6:c.178G>A 7:g.55142375G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152781 2152781 2021791 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T504 2658618 2518777 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51767379 COSM85894 132557468 c.2392G>A p.V798I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 27149842 NS NS 76.41 ENSP00000395243.3:p.Val798Ile ENST00000454757.6:c.2392G>A 7:g.55191776G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1063626 1063626 979671 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 45 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A114-T-S35 2757427 2616005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 61 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0004523-T01-IM5 2720924 2579745 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51780877 COSM26717 99375410 c.2579A>T p.K860I Substitution - Missense het 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Lys860Ile ENST00000275493.6:c.2579A>T 7:g.55191828A>T EGFR ENST00000275493.6 3633 3236 S0389 897615 815238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15118125 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1451129 1451129 1375272 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS 56 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1074903 1074903 990157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51794784 COSM13182 99375617 c.2203G>A p.G735S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Reported in another cancer sample as somatic 17505415 surgery fresh/frozen primary 71 ENSP00000275493.2:p.Gly735Ser ENST00000275493.6:c.2203G>A 7:g.55174740G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KD530 1007063 924271 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51811749 COSM6242 132561254 c.2170G>T p.V724L Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .9836 Confirmed somatic variant 16863509 NS NS ENSP00000395243.3:p.Val724Leu ENST00000454757.6:c.2170G>T 7:g.55181314G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KD530 1007063 924271 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 16863509 NS NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-YL-A8SP-01 2339707 2204690 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51810684 COSM5415932 132562232 c.2854T>G p.F952V Substitution - Missense 38 7:55201230-55201230 + - PATHOGENIC .9773 Confirmed somatic variant 435 NS primary 58 ENSP00000395243.3:p.Phe952Val ENST00000454757.6:c.2854T>G 7:g.55201230T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 ICGC_GBM53_tumor 2634861 2495257 central_nervous_system brain NS NS primitive_neuroectodermal_tumour-medulloblastoma NS NS NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 379 NS primary 5 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458702 1458702 1382677 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982777 982777 898496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51788393 COSM13979 99391974 c.2170G>A p.G724S Substitution - Missense 38 7:55174029-55174029 + - PATHOGENIC .98273 Reported in another cancer sample as somatic 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Gly724Ser ENST00000275493.6:c.2170G>A 7:g.55174029G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A014-T-S59 2758142 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 17306 1423828 1333856 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897851 897851 815473 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51811749 COSM6242 99389560 c.2305G>T p.V769L Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .9836 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Val769Leu ENST00000275493.6:c.2305G>T 7:g.55181314G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51807036 COSM2151966 132561349 c.1652C>G p.P551R Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99615 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000395243.3:p.Pro551Arg ENST00000454757.6:c.1652C>G 7:g.55165344C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 132550339 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000395243.3:p.Ala244Asp ENST00000454757.6:c.731C>A 7:g.55154129C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458694 1458694 1382669 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 ESCC_96 2479594 2342354 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51783269 COSM5637701 133235392 c.2659C>A p.R887S Substitution - Missense 38 7:55198809-55198809 + - PATHOGENIC .92422 Confirmed somatic variant 26873401 NS NS 66 ENSP00000415559.1:p.Arg887Ser ENST00000455089.5:c.2659C>A 7:g.55198809C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876061 2876061 2730576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 77 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G CSRNP2 ENST00000228515.5 1632 16006 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105848868 COSM10012810 101134868 c.1216G>A p.V406M Substitution - Missense 38 12:51064162-51064162 - - .55288 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000228515.1:p.Val406Met ENST00000228515.5:c.1216G>A 12:g.51064162C>T EGFR ENST00000275493.6 3633 3236 2426829 2426829 2289750 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM5010368 178378709 c.? p.C797S Substitution - Missense + Yes Reported in another cancer sample as somatic 25939061 blood-bone marrow recurrent 33 ENSP00000275493.2:p.Cys797Ser EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009856-T01-IM5 2725695 2584516 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51844648 COSM6971178 132555730 c.685A>G p.T229A Substitution - Missense het 38 7:55154083-55154083 + - PATHOGENIC .96224 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000395243.3:p.Thr229Ala ENST00000454757.6:c.685A>G 7:g.55154083A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 004 2492942 2355556 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour benign NS n COSV51768130 COSM21684 132551880 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 26437033 NS NS ENSP00000395243.3:p.Thr218Pro ENST00000454757.6:c.652A>C 7:g.55154050A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T504 2658618 2518777 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51767379 COSM85894 133213549 c.2392G>A p.V798I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 27149842 NS NS 76.41 ENSP00000415559.1:p.Val798Ile ENST00000455089.5:c.2392G>A 7:g.55191776G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0013374-T01-IM5 2803847 2660597 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51793336 COSM6214981 132580644 c.1528T>C p.C510R Substitution - Missense het 38 7:55163764-55163764 + - PATHOGENIC .99407 Confirmed somatic variant 29316426 surgery-fixed primary 79 ENSP00000395243.3:p.Cys510Arg ENST00000454757.6:c.1528T>C 7:g.55163764T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-3652-01 2120285 1994521 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51800797 COSM3412178 132557507 c.620G>C p.R207P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 329 NS NS 60 ENSP00000395243.3:p.Arg207Pro ENST00000454757.6:c.620G>C 7:g.55154018G>C EGFR ENST00000275493.6 3633 3236 1001260 1001260 918483 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A114-T-S35 2757427 2616005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 61 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006116-T01-IM5 2722496 2581317 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982886 982886 898605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0010754-T01-IM5 2830302 2686117 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51805749 COSM6976991 99375210 c.2644G>A p.A882T Substitution - Missense 38 7:55192784-55192784 + - PATHOGENIC .95513 Confirmed somatic variant 30205045 surgery-fixed primary 54 ENSP00000275493.2:p.Ala882Thr ENST00000275493.6:c.2644G>A 7:g.55192784G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811924 2811924 2668484 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51823614 COSM4170219 132547383 c.2120C>T p.S707F Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98332 Confirmed somatic variant 31534501 surgery-fixed NS 61 ENSP00000395243.3:p.Ser707Phe ENST00000454757.6:c.2120C>T 7:g.55174792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 961853 961853 878137 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16467080 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CTS107 2393050 2255881 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 25189529 surgery fresh/frozen NS 49 ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 CTS107 2393050 2255881 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 49 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920030 920030 837109 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KD530 1007063 924271 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51811749 COSM6242 133217384 c.2170G>T p.V724L Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .9836 Confirmed somatic variant 16863509 NS NS ENSP00000415559.1:p.Val724Leu ENST00000455089.5:c.2170G>T 7:g.55181314G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KD530 1007063 924271 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 16863509 NS NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-YL-A8SP-01 2339707 2204690 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51810684 COSM5415932 133218492 c.2854T>G p.F952V Substitution - Missense 38 7:55201230-55201230 + - PATHOGENIC .9773 Confirmed somatic variant 435 NS primary 58 ENSP00000415559.1:p.Phe952Val ENST00000455089.5:c.2854T>G 7:g.55201230T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003104-T01-IM5 2719600 2578421 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51779162 COSM21689 132548259 c.1652C>T p.P551L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Pro551Leu ENST00000454757.6:c.1652C>T 7:g.55165344C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458702 1458702 1382677 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004442-T01-IM5 2720853 2579674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51860610 COSM6936113 132598714 c.2158G>T p.V720L Substitution - Missense het 38 7:55181302-55181302 + - PATHOGENIC .9825 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Val720Leu ENST00000454757.6:c.2158G>T 7:g.55181302G>T EGFR ENST00000275493.6 3633 3236 982866 982866 898585 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862716 2862716 2717879 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 31386689 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1435970 1435970 1345249 lung left_lower_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 20439191 surgery fresh/frozen NS 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895114 1895114 1783806 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1541736 1541736 1464040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 21469767 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1135426 1135426 1047990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 18676744 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1668527 1668527 1581820 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1668454 1668454 1581747 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 22523180 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1983758 1983758 1869994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23796143 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1038997 1038997 955574 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17192868 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1895159 1895159 1783851 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 23557218 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 911632 911632 829115 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15870435 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1067065 1067065 983045 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 17537621 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1168009 1168009 1080251 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 19063875 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1166442 1166442 1078756 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 16870303 surgery - NOS NS 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897828 897828 815450 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897814 897814 815436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Reported in another cancer sample as somatic 15604253 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982864 982864 898583 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1004990 1004990 922202 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A014-T-S59 2758142 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BD177T 2459808 2322645 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV51776869 COSM3266637 132554193 c.2463G>C p.E821D Substitution - Missense 38 7:55191847-55191847 + - PATHOGENIC .9541 Confirmed somatic variant 658 NS primary 59 ENSP00000395243.3:p.Glu821Asp ENST00000454757.6:c.2463G>C 7:g.55191847G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 133205223 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000415559.1:p.Ala244Asp ENST00000455089.5:c.731C>A 7:g.55154129C>A EGFR ENST00000275493.6 3633 3236 1816947 1816947 1716115 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Reported in another cancer sample as somatic 23180674 surgery-fixed NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1879560 1879560 1770062 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Reported in another cancer sample as somatic 23470965 NS recurrent ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 MSU2-a 2809971 2666633 large_intestine caecum NS NS adenoma villous NS NS y COSV51784286 COSM6652281 99383082 c.116C>T p.T39M Substitution - Missense 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000275493.2:p.Thr39Met ENST00000275493.6:c.116C>T 7:g.55142313C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51807036 COSM2151966 133217490 c.1652C>G p.P551R Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99615 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000415559.1:p.Pro551Arg ENST00000455089.5:c.1652C>G 7:g.55165344C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458694 1458694 1382669 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0012113-T01-IM5 2727253 2586074 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51851189 COSM6982714 99391278 c.1405T>G p.L469V Substitution - Missense het 38 7:55160245-55160245 + - NEUTRAL .32338 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu469Val ENST00000275493.6:c.1405T>G 7:g.55160245T>G EGFR ENST00000275493.6 3633 3236 2665553 2665553 2525262 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51789625 COSM13197 99376708 c.2590G>A p.A864T Substitution - Missense 38 7:55191839-55191839 + - PATHOGENIC .9615 Confirmed somatic variant 28984303 surgery-fixed NS ENSP00000275493.2:p.Ala864Thr ENST00000275493.6:c.2590G>A 7:g.55191839G>A EGFR ENST00000275493.6 3633 3236 2812087 2812087 2668553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51823614 COSM4170219 99373800 c.2255C>T p.S752F Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98332 Confirmed somatic variant 31534501 circulating tumour NS 76 ENSP00000275493.2:p.Ser752Phe ENST00000275493.6:c.2255C>T 7:g.55174792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003360-T01-IM5 2719851 2578672 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009856-T01-IM5 2725695 2584516 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51844648 COSM6971178 133211642 c.685A>G p.T229A Substitution - Missense het 38 7:55154083-55154083 + - PATHOGENIC .96224 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000415559.1:p.Thr229Ala ENST00000455089.5:c.685A>G 7:g.55154083A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 004 2492942 2355556 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour benign NS n COSV51768130 COSM21684 133206822 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 26437033 NS NS ENSP00000415559.1:p.Thr218Pro ENST00000455089.5:c.652A>C 7:g.55154050A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0013374-T01-IM5 2803847 2660597 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51793336 COSM6214981 133241745 c.1528T>C p.C510R Substitution - Missense het 38 7:55163764-55163764 + - PATHOGENIC .99407 Confirmed somatic variant 29316426 surgery-fixed primary 79 ENSP00000415559.1:p.Cys510Arg ENST00000455089.5:c.1528T>C 7:g.55163764T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-3652-01 2120285 1994521 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51800797 COSM3412178 133213607 c.620G>C p.R207P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 329 NS NS 60 ENSP00000415559.1:p.Arg207Pro ENST00000455089.5:c.620G>C 7:g.55154018G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0749-01 1337861 1248246 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0749-01 1337861 1248246 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849240 COSM6923103 132553474 c.1624G>A p.D542N Substitution - Missense het 38 7:55165316-55165316 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Asp542Asn ENST00000454757.6:c.1624G>A 7:g.55165316G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849201 COSM6923099 132553461 c.1196A>T p.N399I Substitution - Missense het 38 7:55160171-55160171 + - PATHOGENIC .8398 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Asn399Ile ENST00000454757.6:c.1196A>T 7:g.55160171A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849279 COSM6923107 132553489 c.1635C>A p.H545Q Substitution - Missense het 38 7:55165327-55165327 + - PATHOGENIC .98427 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.His545Gln ENST00000454757.6:c.1635C>A 7:g.55165327C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006116-T01-IM5 2722496 2581317 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982886 982886 898605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G KANK1_ENST00000382293 ENST00000382293.7 3585 19309 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105916423 COSM10012928 116924490 c.2603A>G p.D868G Substitution - Missense 38 9:732449-732449 + - PATHOGENIC .96909 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000371730.3:p.Asp868Gly ENST00000382293.7:c.2603A>G 9:g.732449A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004927-T01-IM5 2721336 2580157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811924 2811924 2668484 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51823614 COSM4170219 133202511 c.2120C>T p.S707F Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98332 Confirmed somatic variant 31534501 surgery-fixed NS 61 ENSP00000415559.1:p.Ser707Phe ENST00000455089.5:c.2120C>T 7:g.55174792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489257 1489257 1412415 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 47 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 961853 961853 878137 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16467080 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010750-T01-IM5 2726431 2585252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MELA_29896 2760739 2619272 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV104576959 COSM9291837 132588413 c.3316T>A p.F1106I Substitution - Missense 38 7:55205435-55205435 + - NEUTRAL .31568 Confirmed somatic variant 30178487 surgery fresh/frozen metastasis 19 ENSP00000395243.3:p.Phe1106Ile ENST00000454757.6:c.3316T>A 7:g.55205435T>A EGFR ENST00000275493.6 3633 3236 TCGA-14-0813-01 1337991 1248376 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779162 COSM21689 99374883 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 329 surgery fresh/frozen NS 78 ENSP00000275493.2:p.Pro596Leu ENST00000275493.6:c.1787C>T 7:g.55165344C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003104-T01-IM5 2719600 2578421 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51779162 COSM21689 133203297 c.1652C>T p.P551L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Pro551Leu ENST00000455089.5:c.1652C>T 7:g.55165344C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009096-T01-IM5 2725087 2583908 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004442-T01-IM5 2720853 2579674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51860610 COSM6936113 133262523 c.2158G>T p.V720L Substitution - Missense het 38 7:55181302-55181302 + - PATHOGENIC .9825 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Val720Leu ENST00000455089.5:c.2158G>T 7:g.55181302G>T EGFR ENST00000275493.6 3633 3236 2811936 2811936 2668488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed metastasis 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1170513 1170513 1082647 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 19117057 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000681-T01-IM3 2715774 2574595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 400_R4 2910227 2764189 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV104577128 COSM9497116 99442635 c.1471A>G p.I491V Substitution - Missense het 38 7:55160311-55160311 + - NEUTRAL .12941 Confirmed somatic variant 27639803 short-term culture NS 69 ENSP00000275493.2:p.Ile491Val ENST00000275493.6:c.1471A>G 7:g.55160311A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982864 982864 898583 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1005012 1005012 922224 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1896424 1896424 1785116 lung right NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 23540867 surgery - NOS NS 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 ESCC_35 2479543 2342303 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51774192 COSM5628704 99424390 c.596G>C p.C199S Substitution - Missense 38 7:55151330-55151330 + - PATHOGENIC .99573 Confirmed somatic variant 26873401 NS NS 68 ENSP00000275493.2:p.Cys199Ser ENST00000275493.6:c.596G>C 7:g.55151330G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BD177T 2459808 2322645 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV51776869 COSM3266637 133209516 c.2463G>C p.E821D Substitution - Missense 38 7:55191847-55191847 + - PATHOGENIC .9541 Confirmed somatic variant 658 NS primary 59 ENSP00000415559.1:p.Glu821Asp ENST00000455089.5:c.2463G>C 7:g.55191847G>C EGFR ENST00000275493.6 3633 3236 1458696 1458696 1382671 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460098 1460098 1383975 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004232-T01-IM5 2720640 2579461 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-19-2620-01 2120303 1994539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 70 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 1487002 1487002 1410620 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51803719 COSM53291 99377257 c.2485G>A p.E829K Substitution - Missense 38 7:55191734-55191734 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 65 ENSP00000275493.2:p.Glu829Lys ENST00000275493.6:c.2485G>A 7:g.55191734G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003360-T01-IM5 2719851 2578672 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211134 1211134 1123002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 42 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 GB057T 2634022 2494418 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 672 NS primary ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004066-T02-IM5 2720467 2579288 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004066-T02-IM5 2720467 2579288 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0749-01 1337861 1248246 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0749-01 1337861 1248246 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S02279_1 2480887 2343632 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV51810698 COSM5683869 132575579 c.1202C>A p.T401K Substitution - Missense 38 7:55160177-55160177 + - NEUTRAL .09422 Confirmed somatic variant 26168399 surgery fresh/frozen primary 58 ENSP00000395243.3:p.Thr401Lys ENST00000454757.6:c.1202C>A 7:g.55160177C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849279 COSM6923107 133208643 c.1635C>A p.H545Q Substitution - Missense het 38 7:55165327-55165327 + - PATHOGENIC .98427 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.His545Gln ENST00000455089.5:c.1635C>A 7:g.55165327C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849240 COSM6923103 133208620 c.1624G>A p.D542N Substitution - Missense het 38 7:55165316-55165316 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Asp542Asn ENST00000455089.5:c.1624G>A 7:g.55165316G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849201 COSM6923099 133208599 c.1196A>T p.N399I Substitution - Missense het 38 7:55160171-55160171 + - PATHOGENIC .8398 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Asn399Ile ENST00000455089.5:c.1196A>T 7:g.55160171A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004927-T01-IM5 2721336 2580157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003264-T02-IM5 2719759 2578580 autonomic_ganglia retroperitoneum NS NS neuroblastoma NS NS NS n COSV51771754 COSM6965217 132558306 c.2404A>T p.T802S Substitution - Missense het 38 7:55191788-55191788 + - PATHOGENIC .9694 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr802Ser ENST00000454757.6:c.2404A>T 7:g.55191788A>T EGFR ENST00000275493.6 3633 3236 ESCC-D3 2394863 2257694 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51854767 COSM5046159 99401469 c.2560A>C p.T854P Substitution - Missense 38 7:55191809-55191809 + - PATHOGENIC .98739 Confirmed somatic variant 24686850 NS NS 66 ENSP00000275493.2:p.Thr854Pro ENST00000275493.6:c.2560A>C 7:g.55191809A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489257 1489257 1412415 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 47 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005004 1005004 922216 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-FG-6692-01 2194411 2062689 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 63 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1317183 1317183 1228084 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20126411 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 non-ocular_carcinoma_3 2580640 2441977 skin neck NS NS adnexal_tumour sebaceous_carcinoma NS NS n COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 27287813 surgery-fixed primary ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 1505363 1505363 1428241 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51797168 COSM87247 99408741 c.2587G>A p.G863S Substitution - Missense 38 7:55191836-55191836 + - PATHOGENIC .94673 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000275493.2:p.Gly863Ser ENST00000275493.6:c.2587G>A 7:g.55191836G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010750-T01-IM5 2726431 2585252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 6360 915996 833395 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005015 1005015 922227 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 TCGA-S3-A6ZG-01 2187686 2055964 breast NS NS NS carcinoma NS NS NS y COSV99287475 COSM7699858 99386743 c.2783A>T p.E928V Substitution - Missense 38 7:55198798-55198798 + - PATHOGENIC .98866 Confirmed somatic variant 414 NS NS 71 ENSP00000275493.2:p.Glu928Val ENST00000275493.6:c.2783A>T 7:g.55198798A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004971-T01-IM5 2721381 2580202 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2665872 2665872 2525580 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM6842526 178390218 c.? p.T363N Substitution - Missense + - Confirmed somatic variant 28979142 surgery - NOS NS ENSP00000275493.2:p.Thr363Asn EGFR ENST00000275493.6 3633 3236 TCGA-44-A4SU-01 2194780 2063058 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 417 NS NS 67 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 TCGA-44-A4SU-01 2194780 2063058 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 417 NS NS 67 ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 43 2605251 2466142 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 25376516 surgery - NOS NS 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1005008 1005008 922220 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009096-T01-IM5 2725087 2583908 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD6907a 1504118 1426996 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51857264 COSM4384115 132591852 c.592C>T p.P198S Substitution - Missense 38 7:55152644-55152644 + - PATHOGENIC .99273 Confirmed somatic variant 24030381 NS NS ENSP00000395243.3:p.Pro198Ser ENST00000454757.6:c.592C>T 7:g.55152644C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 132 898396 816008 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471566 1471566 1395305 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471566 1471566 1395305 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51825402 COSM53201 132581510 c.2411A>G p.Q804R Substitution - Missense 38 7:55191795-55191795 + - PATHOGENIC .9858 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Gln804Arg ENST00000454757.6:c.2411A>G 7:g.55191795A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000681-T01-IM3 2715774 2574595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 TCGA-DU-6407-02 2185941 2054238 central_nervous_system brain NS NS glioma NS NS NS y COSV51859563 COSM6910210 99376263 c.2509G>A p.D837N Substitution - Missense 38 7:55191758-55191758 + - PATHOGENIC .98912 Confirmed somatic variant 545 NS NS 35 ENSP00000275493.2:p.Asp837Asn ENST00000275493.6:c.2509G>A 7:g.55191758G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460098 1460098 1383975 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471536 1471536 1395275 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811979 2811979 2668502 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004232-T01-IM5 2720640 2579461 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KD938 1004978 922190 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary 78 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471550 1471550 1395289 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-19-2620-01 2120303 1994539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 70 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 2675076 2675076 2534351 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 29110836 surgery-fixed recurrent 56 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1001251 1001251 918474 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 R098-I1 2813503 2669895 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 132552126 c.674A>G p.Y225C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 28263318 surgery fresh/frozen NS 51 ENSP00000395243.3:p.Tyr225Cys ENST00000454757.6:c.674A>G 7:g.55154072A>G EGFR ENST00000275493.6 3633 3236 P-0003752-T02-IM5 2720241 2579062 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211134 1211134 1123002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 42 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-13-1501-01 1474878 1398577 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51855038 COSM70574 132602137 c.3356A>G p.Q1119R Substitution - Missense het 38 7:55205475-55205475 + - PATHOGENIC .95786 Confirmed somatic variant 21720365 331 NS primary 50 ENSP00000395243.3:p.Gln1119Arg ENST00000454757.6:c.3356A>G 7:g.55205475A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004066-T02-IM5 2720467 2579288 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004066-T02-IM5 2720467 2579288 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 2591379 2591379 2452339 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 S0037 2528812 2390668 liver NS NS NS NS NS NS NS n COSM5885273 178380256 c.? p.D587H Substitution - Missense + - Confirmed somatic variant 27245685 surgery-fixed metastasis 55 EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_C22 1863703 1754594 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_C22 1863703 1754594 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51767386 COSM18423 132564484 c.2365G>T p.V789L Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .9903 Confirmed somatic variant 22975805 surgery fresh/frozen primary 73 ENSP00000395243.3:p.Val789Leu ENST00000454757.6:c.2365G>T 7:g.55191749G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S02279_1 2480887 2343632 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV51810698 COSM5683869 133234699 c.1202C>A p.T401K Substitution - Missense 38 7:55160177-55160177 + - NEUTRAL .09422 Confirmed somatic variant 26168399 surgery fresh/frozen primary 58 ENSP00000415559.1:p.Thr401Lys ENST00000455089.5:c.1202C>A 7:g.55160177C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003264-T02-IM5 2719759 2578580 autonomic_ganglia retroperitoneum NS NS neuroblastoma NS NS NS n COSV51771754 COSM6965217 133214393 c.2404A>T p.T802S Substitution - Missense het 38 7:55191788-55191788 + - PATHOGENIC .9694 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr802Ser ENST00000455089.5:c.2404A>T 7:g.55191788A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005004 1005004 922216 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G ABCC8_ENST00000642271 ENST00000642271.1 4743 59 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105879570 COSM10012873 177246913 c.2054T>C p.F685S Substitution - Missense 38 11:17427926-17427926 - - PATHOGENIC .98111 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000493749.1:p.Phe685Ser ENST00000642271.1:c.2054T>C 11:g.17427926A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FP-7829-01 2198081 2066359 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51829933 COSM3881812 132568370 c.836G>A p.R279H Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .95186 Confirmed somatic variant 541 NS NS 69 ENSP00000395243.3:p.Arg279His ENST00000454757.6:c.836G>A 7:g.55155911G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005015 1005015 922227 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811986 2811986 2668504 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 57 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004971-T01-IM5 2721381 2580202 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152764 2152764 2021774 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 132 898396 816008 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD6907a 1504118 1426996 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51857264 COSM4384115 133254535 c.592C>T p.P198S Substitution - Missense 38 7:55152644-55152644 + - PATHOGENIC .99273 Confirmed somatic variant 24030381 NS NS ENSP00000415559.1:p.Pro198Ser ENST00000455089.5:c.592C>T 7:g.55152644C>T EGFR ENST00000275493.6 3633 3236 TCGA-16-1045-01 1338027 1248412 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 99378725 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 surgery fresh/frozen NS 49 ENSP00000275493.2:p.Thr263Pro ENST00000275493.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471566 1471566 1395305 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51825402 COSM53201 133242605 c.2411A>G p.Q804R Substitution - Missense 38 7:55191795-55191795 + - PATHOGENIC .9858 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Gln804Arg ENST00000455089.5:c.2411A>G 7:g.55191795A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471566 1471566 1395305 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 GCYC_110_T 2747564 2606267 stomach NS NS NS carcinoma NS NS NS y COSV99293603 COSM8524528 99458819 c.3192C>A p.S1064R Substitution - Missense 38 7:55202546-55202546 + - PATHOGENIC .94645 Confirmed somatic variant 683 NS primary ENSP00000275493.2:p.Ser1064Arg ENST00000275493.6:c.3192C>A 7:g.55202546C>A EGFR ENST00000275493.6 3633 3236 TCGA-DF-A2L0-01 2457392 2320229 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51809160 COSM382935 99378402 c.1606G>A p.V536M Substitution - Missense 38 7:55161606-55161606 + - PATHOGENIC .98051 Confirmed somatic variant 419 NS primary 60 ENSP00000275493.2:p.Val536Met ENST00000275493.6:c.1606G>A 7:g.55161606G>A EGFR ENST00000275493.6 3633 3236 2591349 2591349 2452309 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591349 2591349 2452309 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0007870-T01-IM5 2724083 2582904 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1031892 1031892 948683 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17085664 NS primary 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471548 1471548 1395287 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471536 1471536 1395275 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0002124-T01-IM3 2718419 2577240 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51806564 COSM6920868 99383183 c.2006G>A p.R669Q Substitution - Missense het 38 7:55173069-55173069 + - PATHOGENIC .99699 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Arg669Gln ENST00000275493.6:c.2006G>A 7:g.55173069G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811979 2811979 2668502 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876663 2876663 2731178 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 surgery fresh/frozen NS 60 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 2876663 2876663 2731178 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 surgery fresh/frozen NS 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206733 1206733 1118611 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51796944 COSM28537 99382129 c.2560A>G p.T854A Substitution - Missense 38 7:55191809-55191809 + - PATHOGENIC .9858 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Thr854Ala ENST00000275493.6:c.2560A>G 7:g.55191809A>G EGFR ENST00000275493.6 3633 3236 1206733 1206733 1118611 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51837705 COSM29577 99392755 c.2563G>A p.D855N Substitution - Missense 38 7:55191812-55191812 + - PATHOGENIC .98898 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Asp855Asn ENST00000275493.6:c.2563G>A 7:g.55191812G>A EGFR ENST00000275493.6 3633 3236 P-0005393-T01-IM5 2721796 2580617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471550 1471550 1395289 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1468627 1468627 1392378 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 447 898389 816001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KD938 1004978 922190 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary 78 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-05-4402-01 1780061 1684060 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51795112 COSM23633 99405507 c.2276T>A p.I759N Substitution - Missense 38 7:55174813-55174813 + - PATHOGENIC .99182 Confirmed somatic variant 417 fresh/frozen - NOS primary 57 ENSP00000275493.2:p.Ile759Asn ENST00000275493.6:c.2276T>A 7:g.55174813T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460126 1460126 1384003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51797094 COSM52934 132606962 c.2084T>C p.I695T Substitution - Missense 38 7:55174756-55174756 + - PATHOGENIC .99336 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000395243.3:p.Ile695Thr ENST00000454757.6:c.2084T>C 7:g.55174756T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876060 2876060 2730575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 77 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876060 2876060 2730575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 77 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 R098-I1 2813503 2669895 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 133207083 c.674A>G p.Y225C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 28263318 surgery fresh/frozen NS 51 ENSP00000415559.1:p.Tyr225Cys ENST00000455089.5:c.674A>G 7:g.55154072A>G EGFR ENST00000275493.6 3633 3236 1498497 1498497 1421375 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21040950 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0000677-T01-IM3 2715765 2574586 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51860516 COSM6911906 99401543 c.1143C>G p.F381L Substitution - Missense het 38 7:55156768-55156768 + - PATHOGENIC .96387 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Phe381Leu ENST00000275493.6:c.1143C>G 7:g.55156768C>G EGFR ENST00000275493.6 3633 3236 1489262 1489262 1412420 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103794 1103794 1018046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152781 2152781 2021791 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1063626 1063626 979671 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 45 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 945807 945807 862333 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 16144918 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_C22 1863703 1754594 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_C22 1863703 1754594 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51767386 COSM18423 133220856 c.2365G>T p.V789L Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .9903 Confirmed somatic variant 22975805 surgery fresh/frozen primary 73 ENSP00000415559.1:p.Val789Leu ENST00000455089.5:c.2365G>T 7:g.55191749G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1790522 1790522 1693501 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 ICGC_GBM53_tumor 2634861 2495257 central_nervous_system brain NS NS primitive_neuroectodermal_tumour-medulloblastoma NS NS NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 379 NS primary 5 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM19-I2 2813466 2669858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-CV-7427-01 2193557 2061835 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99291701 COSM8368660 132566627 c.2001C>G p.F667L Substitution - Missense 38 7:55173995-55173995 + - PATHOGENIC .78822 Confirmed somatic variant 627 NS NS 73 ENSP00000395243.3:p.Phe667Leu ENST00000454757.6:c.2001C>G 7:g.55173995C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A-2A 2746111 2604814 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51851236 COSM7304351 132591330 c.1756C>T p.P586S Substitution - Missense 38 7:55171185-55171185 + - PATHOGENIC .97683 Confirmed somatic variant 646 NS primary 20 ENSP00000395243.3:p.Pro586Ser ENST00000454757.6:c.1756C>T 7:g.55171185C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982858 982858 898577 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FP-7829-01 2198081 2066359 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51829933 COSM3881812 133225348 c.836G>A p.R279H Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .95186 Confirmed somatic variant 541 NS NS 69 ENSP00000415559.1:p.Arg279His ENST00000455089.5:c.836G>A 7:g.55155911G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004846-T01-IM5 2721249 2580070 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51779091 COSM2155593 132560457 c.953C>T p.T318I Substitution - Missense het 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Thr318Ile ENST00000454757.6:c.953C>T 7:g.55156614C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008300-T01-IM5 2724426 2583247 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003062-T01-IM3 2719258 2578079 skin NS NS NS malignant_melanoma NS NS NS n COSV51832266 COSM6926001 132567566 c.3274G>A p.E1092K Substitution - Missense het 38 7:55205393-55205393 + - PATHOGENIC .98342 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Glu1092Lys ENST00000454757.6:c.3274G>A 7:g.55205393G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_S35 1863746 1754637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 82 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_S35 1863746 1754637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 22975805 surgery fresh/frozen primary 82 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811986 2811986 2668504 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 57 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000580-T01-IM3 2715559 2574380 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000580-T01-IM3 2715559 2574380 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 ESCC_96 2479594 2342354 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51783269 COSM5637701 99408304 c.2794C>A p.R932S Substitution - Missense 38 7:55198809-55198809 + - PATHOGENIC .92422 Confirmed somatic variant 26873401 NS NS 66 ENSP00000275493.2:p.Arg932Ser ENST00000275493.6:c.2794C>A 7:g.55198809C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-D8-A1JF-01 1900052 1788736 breast NS NS NS carcinoma NS NS NS y COSV51781835 COSM174732 132552286 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 414 fresh/frozen - NOS primary 79 ENSP00000395243.3:p.Glu114Lys ENST00000454757.6:c.340G>A 7:g.55143404G>A EGFR ENST00000275493.6 3633 3236 2876061 2876061 2730576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 77 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876656 2876656 2731171 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 surgery-fixed NS 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152764 2152764 2021774 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-EB-A44P-01 2121603 1995839 skin NS NS NS malignant_melanoma NS NS NS y COSV51857489 COSM3639760 99428317 c.3533C>T p.P1178L Substitution - Missense 38 7:55205517-55205517 + - PATHOGENIC .96485 Confirmed somatic variant 540 NS NS 58 ENSP00000275493.2:p.Pro1178Leu ENST00000275493.6:c.3533C>T 7:g.55205517C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-97-A4M7-01 2194880 2063158 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876040 2876040 2730555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 132557758 c.2018T>A p.L673Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Confirmed somatic variant 29506987 circulating tumour recurrent 66 ENSP00000395243.3:p.Leu673Gln ENST00000454757.6:c.2018T>A 7:g.55174012T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876040 2876040 2730555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 T504 2658618 2518777 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51767379 COSM85894 99384993 c.2527G>A p.V843I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 27149842 NS NS 76.41 ENSP00000275493.2:p.Val843Ile ENST00000275493.6:c.2527G>A 7:g.55191776G>A EGFR ENST00000275493.6 3633 3236 A114-T-S35 2757427 2616005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003222-T01-IM5 2719716 2578537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51841941 COSM6927106 132550720 c.711G>T p.E237D Substitution - Missense het 38 7:55154109-55154109 + - NEUTRAL .06117 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000395243.3:p.Glu237Asp ENST00000454757.6:c.711G>T 7:g.55154109G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-19-1789 2108040 1985901 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51850088 COSM2156010 132570613 c.865C>T p.R289C Substitution - Missense 38 7:55155940-55155940 + - PATHOGENIC .91604 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Arg289Cys ENST00000454757.6:c.865C>T 7:g.55155940C>T EGFR ENST00000275493.6 3633 3236 KD530 1007063 924271 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 16863509 NS NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 KD530 1007063 924271 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51811749 COSM6242 99389560 c.2305G>T p.V769L Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .9836 Confirmed somatic variant 16863509 NS NS ENSP00000275493.2:p.Val769Leu ENST00000275493.6:c.2305G>T 7:g.55181314G>T EGFR ENST00000275493.6 3633 3236 TCGA-YL-A8SP-01 2339707 2204690 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51810684 COSM5415932 99390833 c.2989T>G p.F997V Substitution - Missense 38 7:55201230-55201230 + - PATHOGENIC .9773 Confirmed somatic variant 435 NS primary 58 ENSP00000275493.2:p.Phe997Val ENST00000275493.6:c.2989T>G 7:g.55201230T>G EGFR ENST00000275493.6 3633 3236 1458702 1458702 1382677 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811953 2811953 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 31534501 circulating tumour NS 69 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811953 2811953 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 132551897 c.2447T>G p.L816R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 31534501 circulating tumour NS 69 ENSP00000395243.3:p.Leu816Arg ENST00000454757.6:c.2447T>G 7:g.55191831T>G EGFR ENST00000275493.6 3633 3236 A014-T-S59 2758142 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 99377226 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000275493.2:p.Ala289Asp ENST00000275493.6:c.866C>A 7:g.55154129C>A EGFR ENST00000275493.6 3633 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51807036 COSM2151966 99389686 c.1787C>G p.P596R Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99615 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000275493.2:p.Pro596Arg ENST00000275493.6:c.1787C>G 7:g.55165344C>G EGFR ENST00000275493.6 3633 3236 1458694 1458694 1382669 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460126 1460126 1384003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51797094 COSM52934 133271510 c.2084T>C p.I695T Substitution - Missense 38 7:55174756-55174756 + - PATHOGENIC .99336 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000415559.1:p.Ile695Thr ENST00000455089.5:c.2084T>C 7:g.55174756T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876060 2876060 2730575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 77 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876060 2876060 2730575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 77 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 004 2492942 2355556 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour benign NS n COSV51768130 COSM21684 99378725 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 26437033 NS NS ENSP00000275493.2:p.Thr263Pro ENST00000275493.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-02-0003 2107930 1985791 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51809225 COSM35825 132574944 c.1724G>A p.C575Y Substitution - Missense 38 7:55165416-55165416 + - PATHOGENIC .99893 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Cys575Tyr ENST00000454757.6:c.1724G>A 7:g.55165416G>A EGFR ENST00000275493.6 3633 3236 P-0009856-T01-IM5 2725695 2584516 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51844648 COSM6971178 99383021 c.820A>G p.T274A Substitution - Missense het 38 7:55154083-55154083 + - PATHOGENIC .96224 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000275493.2:p.Thr274Ala ENST00000275493.6:c.820A>G 7:g.55154083A>G EGFR ENST00000275493.6 3633 3236 TCGA-12-3652-01 2120285 1994521 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51800797 COSM3412178 99385042 c.755G>C p.R252P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 329 NS NS 60 ENSP00000275493.2:p.Arg252Pro ENST00000275493.6:c.755G>C 7:g.55154018G>C EGFR ENST00000275493.6 3633 3236 P-0013374-T01-IM5 2803847 2660597 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51793336 COSM6214981 99416047 c.1663T>C p.C555R Substitution - Missense het 38 7:55163764-55163764 + - PATHOGENIC .99407 Confirmed somatic variant 29316426 surgery-fixed primary 79 ENSP00000275493.2:p.Cys555Arg ENST00000275493.6:c.1663T>C 7:g.55163764T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103794 1103794 1018046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0006116-T01-IM5 2722496 2581317 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982886 982886 898605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2811924 2811924 2668484 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51823614 COSM4170219 99373800 c.2255C>T p.S752F Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98332 Confirmed somatic variant 31534501 surgery-fixed NS 61 ENSP00000275493.2:p.Ser752Phe ENST00000275493.6:c.2255C>T 7:g.55174792C>T EGFR ENST00000275493.6 3633 3236 961853 961853 878137 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16467080 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1790522 1790522 1693501 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-CV-7427-01 2193557 2061835 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99291701 COSM8368660 133223200 c.2001C>G p.F667L Substitution - Missense 38 7:55173995-55173995 + - PATHOGENIC .78822 Confirmed somatic variant 627 NS NS 73 ENSP00000415559.1:p.Phe667Leu ENST00000455089.5:c.2001C>G 7:g.55173995C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM19-I2 2813466 2669858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 P-0003104-T01-IM5 2719600 2578421 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51779162 COSM21689 99374883 c.1787C>T p.P596L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Pro596Leu ENST00000275493.6:c.1787C>T 7:g.55165344C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004846-T01-IM5 2721249 2580070 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51779091 COSM2155593 133216524 c.953C>T p.T318I Substitution - Missense het 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Thr318Ile ENST00000455089.5:c.953C>T 7:g.55156614C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982858 982858 898577 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008300-T01-IM5 2724426 2583247 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000906-T01-IM3 2716233 2575054 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765787 COSM2149971 132551380 c.775C>T p.H259Y Substitution - Missense het 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.His259Tyr ENST00000454757.6:c.775C>T 7:g.55155850C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 81 898381 815993 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0004442-T01-IM5 2720853 2579674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51860610 COSM6936113 99439455 c.2293G>T p.V765L Substitution - Missense het 38 7:55181302-55181302 + - PATHOGENIC .9825 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Val765Leu ENST00000275493.6:c.2293G>T 7:g.55181302G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_S35 1863746 1754637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 82 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_S35 1863746 1754637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 22975805 surgery fresh/frozen primary 82 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000580-T01-IM3 2715559 2574380 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000580-T01-IM3 2715559 2574380 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A-2A 2746111 2604814 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51851236 COSM7304351 133253867 c.1756C>T p.P586S Substitution - Missense 38 7:55171185-55171185 + - PATHOGENIC .97683 Confirmed somatic variant 646 NS primary 20 ENSP00000415559.1:p.Pro586Ser ENST00000455089.5:c.1756C>T 7:g.55171185C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-D8-A1JF-01 1900052 1788736 breast NS NS NS carcinoma NS NS NS y COSV51781835 COSM174732 133207258 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 414 fresh/frozen - NOS primary 79 ENSP00000415559.1:p.Glu114Lys ENST00000455089.5:c.340G>A 7:g.55143404G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876656 2876656 2731171 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 surgery-fixed NS 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982864 982864 898583 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2675069 2675069 2534344 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 29110836 surgery-fixed primary 67 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009215-T01-IM5 2725184 2584005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LICA-CN-HCC089T 2634136 2494532 liver NS NS NS other neoplasm NS NS y COSV51832020 COSM5822378 132576722 c.1607A>T p.Q536L Substitution - Missense 38 7:55165299-55165299 + - PATHOGENIC .9451 Confirmed somatic variant 660 NS primary 48 ENSP00000395243.3:p.Gln536Leu ENST00000454757.6:c.1607A>T 7:g.55165299A>T EGFR ENST00000275493.6 3633 3236 BD177T 2459808 2322645 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV51776869 COSM3266637 99381195 c.2598G>C p.E866D Substitution - Missense 38 7:55191847-55191847 + - PATHOGENIC .9541 Confirmed somatic variant 658 NS primary 59 ENSP00000275493.2:p.Glu866Asp ENST00000275493.6:c.2598G>C 7:g.55191847G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-97-A4M7-01 2194880 2063158 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-19-1790-01 2120301 1994537 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51799291 COSM3412201 132550515 c.2284G>C p.D762H Substitution - Missense 38 7:55181428-55181428 + - PATHOGENIC .97226 Confirmed somatic variant 329 NS NS 56 ENSP00000395243.3:p.Asp762His ENST00000454757.6:c.2284G>C 7:g.55181428G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876040 2876040 2730555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G L3MBTL1_ENST00000373135 ENST00000373135.7 2319 15905 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105927443 COSM10012772 113413609 c.1382G>A p.R461K Substitution - Missense 38 20:43534336-43534336 + - PATHOGENIC .99127 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000362227.3:p.Arg461Lys ENST00000373135.7:c.1382G>A 20:g.43534336G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876040 2876040 2730555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 133213822 c.2018T>A p.L673Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Confirmed somatic variant 29506987 circulating tumour recurrent 66 ENSP00000415559.1:p.Leu673Gln ENST00000455089.5:c.2018T>A 7:g.55174012T>A EGFR ENST00000275493.6 3633 3236 P-0003360-T01-IM5 2719851 2578672 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003222-T01-IM5 2719716 2578537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51841941 COSM6927106 133205648 c.711G>T p.E237D Substitution - Missense het 38 7:55154109-55154109 + - NEUTRAL .06117 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000415559.1:p.Glu237Asp ENST00000455089.5:c.711G>T 7:g.55154109G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-19-1789 2108040 1985901 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51850088 COSM2156010 133228282 c.865C>T p.R289C Substitution - Missense 38 7:55155940-55155940 + - PATHOGENIC .91604 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Arg289Cys ENST00000455089.5:c.865C>T 7:g.55155940C>T EGFR ENST00000275493.6 3633 3236 P-0010750-T01-IM5 2726431 2585252 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-06-0749-01 1337861 1248246 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-QH-A6CX-01 2263100 2130084 central_nervous_system brain NS NS glioma NS NS NS y COSV51785554 COSM21688 132548847 c.836G>T p.R279L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 545 NS primary 66 ENSP00000395243.3:p.Arg279Leu ENST00000454757.6:c.836G>T 7:g.55155911G>T EGFR ENST00000275493.6 3633 3236 TCGA-06-0749-01 1337861 1248246 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489252 1489252 1412410 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 59 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849201 COSM6923099 99380386 c.1331A>T p.N444I Substitution - Missense het 38 7:55160171-55160171 + - PATHOGENIC .8398 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Asn444Ile ENST00000275493.6:c.1331A>T 7:g.55160171A>T EGFR ENST00000275493.6 3633 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849279 COSM6923107 99380416 c.1770C>A p.H590Q Substitution - Missense het 38 7:55165327-55165327 + - PATHOGENIC .98427 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.His590Gln ENST00000275493.6:c.1770C>A 7:g.55165327C>A EGFR ENST00000275493.6 3633 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849240 COSM6923103 99380401 c.1759G>A p.D587N Substitution - Missense het 38 7:55165316-55165316 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Asp587Asn ENST00000275493.6:c.1759G>A 7:g.55165316G>A EGFR ENST00000275493.6 3633 3236 P-0004927-T01-IM5 2721336 2580157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AO-A12G-01 1899795 1788479 breast NS NS NS carcinoma NS NS NS y COSV51772564 COSM453241 132566994 c.682A>G p.T228A Substitution - Missense 38 7:55154080-55154080 + - PATHOGENIC .94785 Confirmed somatic variant 414 fresh/frozen - NOS primary 75 ENSP00000395243.3:p.Thr228Ala ENST00000454757.6:c.682A>G 7:g.55154080A>G EGFR ENST00000275493.6 3633 3236 1489257 1489257 1412415 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 47 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MSU3-a 2809972 2666634 large_intestine colon transverse NS adenoma tubulovillous NS NS y COSV99292326 COSM9176305 132574682 c.1444C>T p.R482W Substitution - Missense 38 7:55161579-55161579 + - NEUTRAL .28879 Confirmed somatic variant 26336987 surgery fresh/frozen primary 51 ENSP00000395243.3:p.Arg482Trp ENST00000454757.6:c.1444C>T 7:g.55161579C>T EGFR ENST00000275493.6 3633 3236 1460098 1460098 1383975 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811953 2811953 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 133206840 c.2447T>G p.L816R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 31534501 circulating tumour NS 69 ENSP00000415559.1:p.Leu816Arg ENST00000455089.5:c.2447T>G 7:g.55191831T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811953 2811953 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 31534501 circulating tumour NS 69 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2014_Lung_sq_25_T 2744896 2603599 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 74 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1322234 1322234 1233121 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 41 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A021-T-S17 2757381 2615995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 57 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103795 1103795 1018047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0009096-T01-IM5 2725087 2583908 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 MELA_29896 2760739 2619272 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV104576959 COSM9291837 99426280 c.3451T>A p.F1151I Substitution - Missense 38 7:55205435-55205435 + - NEUTRAL .31568 Confirmed somatic variant 30178487 surgery fresh/frozen metastasis 19 ENSP00000275493.2:p.Phe1151Ile ENST00000275493.6:c.3451T>A 7:g.55205435T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008131-T01-IM5 2724294 2583115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 915621 915621 833020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014893 surgery - NOS NS 55 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 915621 915621 833020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 16014893 surgery - NOS NS 55 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0000681-T01-IM3 2715774 2574595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-02-0003 2107930 1985791 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51809225 COSM35825 133233661 c.1724G>A p.C575Y Substitution - Missense 38 7:55165416-55165416 + - PATHOGENIC .99893 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Cys575Tyr ENST00000455089.5:c.1724G>A 7:g.55165416G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876592 2876592 2731107 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 132560202 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 45 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876592 2876592 2731107 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 45 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CHG-2011-508T 2634354 2494750 liver NS NS NS other neoplasm NS NS y COSV51803297 COSM6285115 132603213 c.3188C>T p.P1063L Substitution - Missense 38 7:55205307-55205307 + - PATHOGENIC .91978 Confirmed somatic variant 660 NS primary 70 ENSP00000395243.3:p.Pro1063Leu ENST00000454757.6:c.3188C>T 7:g.55205307C>T EGFR ENST00000275493.6 3633 3236 P-0004232-T01-IM5 2720640 2579461 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-19-2620-01 2120303 1994539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 70 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MTP18_T1 2875797 2730359 pancreas NS NS NS other dysplasia-in_situ_neoplasm NS NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 32796935 surgery-fixed NS 74 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A GOLGA6L10 ENST00000610657.1 1569 37228 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV73782728 COSM190514 169166640 c.451G>C p.E151Q Substitution - Missense 38 15:82345409-82345409 - - NEUTRAL .02811 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000479362.1:p.Glu151Gln ENST00000610657.1:c.451G>C 15:g.82345409C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 G-2A 2746114 2604817 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51788082 COSM7293955 132574660 c.3218C>T p.A1073V Substitution - Missense 38 7:55205337-55205337 + - NEUTRAL .26149 Confirmed somatic variant 646 NS primary 23 ENSP00000395243.3:p.Ala1073Val ENST00000454757.6:c.3218C>T 7:g.55205337C>T EGFR ENST00000275493.6 3633 3236 1211134 1211134 1123002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 42 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0004066-T02-IM5 2720467 2579288 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 P-0004066-T02-IM5 2720467 2579288 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000906-T01-IM3 2716233 2575054 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765787 COSM2149971 133206295 c.775C>T p.H259Y Substitution - Missense het 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.His259Tyr ENST00000455089.5:c.775C>T 7:g.55155850C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 81 898381 815993 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009215-T01-IM5 2725184 2584005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 S02279_1 2480887 2343632 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV51810698 COSM5683869 99407812 c.1337C>A p.T446K Substitution - Missense 38 7:55160177-55160177 + - NEUTRAL .09422 Confirmed somatic variant 26168399 surgery fresh/frozen primary 58 ENSP00000275493.2:p.Thr446Lys ENST00000275493.6:c.1337C>A 7:g.55160177C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LICA-CN-HCC089T 2634136 2494532 liver NS NS NS other neoplasm NS NS y COSV51832020 COSM5822378 133236474 c.1607A>T p.Q536L Substitution - Missense 38 7:55165299-55165299 + - PATHOGENIC .9451 Confirmed somatic variant 660 NS primary 48 ENSP00000415559.1:p.Gln536Leu ENST00000455089.5:c.1607A>T 7:g.55165299A>T EGFR ENST00000275493.6 3633 3236 P-0003264-T02-IM5 2719759 2578580 autonomic_ganglia retroperitoneum NS NS neuroblastoma NS NS NS n COSV51771754 COSM6965217 99385991 c.2539A>T p.T847S Substitution - Missense het 38 7:55191788-55191788 + - PATHOGENIC .9694 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr847Ser ENST00000275493.6:c.2539A>T 7:g.55191788A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007896-T01-IM5 2724107 2582928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1005004 1005004 922216 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2591381 2591381 2452341 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1005015 1005015 922227 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982851 982851 898570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001171-T01-IM3 2716747 2575568 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51850219 COSM6915112 132555689 c.1711G>T p.V571L Substitution - Missense het 38 7:55165403-55165403 + - PATHOGENIC .98789 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Val571Leu ENST00000454757.6:c.1711G>T 7:g.55165403G>T EGFR ENST00000275493.6 3633 3236 P-0004971-T01-IM5 2721381 2580202 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-19-1790-01 2120301 1994537 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51799291 COSM3412201 133205383 c.2284G>C p.D762H Substitution - Missense 38 7:55181428-55181428 + - PATHOGENIC .97226 Confirmed somatic variant 329 NS NS 56 ENSP00000415559.1:p.Asp762His ENST00000455089.5:c.2284G>C 7:g.55181428G>C EGFR ENST00000275493.6 3633 3236 132 898396 816008 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 PD6907a 1504118 1426996 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51857264 COSM4384115 99431055 c.727C>T p.P243S Substitution - Missense 38 7:55152644-55152644 + - PATHOGENIC .99273 Confirmed somatic variant 24030381 NS NS ENSP00000275493.2:p.Pro243Ser ENST00000275493.6:c.727C>T 7:g.55152644C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003250-T01-IM5 2719745 2578566 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471566 1471566 1395305 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51825402 COSM53201 99417170 c.2546A>G p.Q849R Substitution - Missense 38 7:55191795-55191795 + - PATHOGENIC .9858 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Gln849Arg ENST00000275493.6:c.2546A>G 7:g.55191795A>G EGFR ENST00000275493.6 3633 3236 1471566 1471566 1395305 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008258-T01-IM5 2724397 2583218 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-QH-A6CX-01 2263100 2130084 central_nervous_system brain NS NS glioma NS NS NS y COSV51785554 COSM21688 133203816 c.836G>T p.R279L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 545 NS primary 66 ENSP00000415559.1:p.Arg279Leu ENST00000455089.5:c.836G>T 7:g.55155911G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489252 1489252 1412410 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 59 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594194 1594194 1515168 upper_aerodigestive_tract pharynx hypopharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51804843 COSM12429 132553900 c.2438_2439delinsGT p.L813R Substitution - Missense het 38 7:55191822-55191823 + - Confirmed somatic variant 19726454 surgery fresh/frozen primary 65 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438_2439delinsGT 7:g.55191822_55191823delinsGT EGFR ENST00000275493.6 3633 3236 1471536 1471536 1395275 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2811979 2811979 2668502 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AO-A12G-01 1899795 1788479 breast NS NS NS carcinoma NS NS NS y COSV51772564 COSM453241 133223631 c.682A>G p.T228A Substitution - Missense 38 7:55154080-55154080 + - PATHOGENIC .94785 Confirmed somatic variant 414 fresh/frozen - NOS primary 75 ENSP00000415559.1:p.Thr228Ala ENST00000455089.5:c.682A>G 7:g.55154080A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MSU3-a 2809972 2666634 large_intestine colon transverse NS adenoma tubulovillous NS NS y COSV99292326 COSM9176305 133233205 c.1444C>T p.R482W Substitution - Missense 38 7:55161579-55161579 + - NEUTRAL .28879 Confirmed somatic variant 26336987 surgery fresh/frozen primary 51 ENSP00000415559.1:p.Arg482Trp ENST00000455089.5:c.1444C>T 7:g.55161579C>T SMOX_ENST00000278795 ENST00000278795.7 1599 15862 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105846220 COSM10009557 101111834 c.841C>T p.R281W Substitution - Missense 38 20:4182320-4182320 + - .51649 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000278795.3:p.Arg281Trp ENST00000278795.7:c.841C>T 20:g.4182320C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211147 1211147 1123015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 57 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1471550 1471550 1395289 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 KD938 1004978 922190 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary 78 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2014_Lung_sq_25_T 2744896 2603599 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 74 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-97-8177-01 2194754 2063032 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 59 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1078205 1078205 993455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51843665 COSM25090 132588335 c.2185G>T p.V729L Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .97108 Confirmed somatic variant 17626639 surgery-fixed primary ENSP00000395243.3:p.Val729Leu ENST00000454757.6:c.2185G>T 7:g.55181329G>T EGFR ENST00000275493.6 3633 3236 1468617 1468617 1392368 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 21030498 surgery - NOS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1468617 1468617 1392368 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2675055 2675055 2534330 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1169669 178386037 c.? p.T263P Substitution - Missense + - Confirmed somatic variant 29110836 surgery-fixed recurrent 53 ENSP00000275493.2:p.Thr263Pro EGFR ENST00000275493.6 3633 3236 2675055 2675055 2534330 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Confirmed somatic variant 29110836 surgery-fixed recurrent 53 ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1322234 1322234 1233121 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 41 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812110 2812110 2668565 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 31534501 pleural effusion NS 73 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A021-T-S17 2757381 2615995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 57 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 R098-I1 2813503 2669895 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 99378964 c.809A>G p.Y270C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 28263318 surgery fresh/frozen NS 51 ENSP00000275493.2:p.Tyr270Cys ENST00000275493.6:c.809A>G 7:g.55154072A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103795 1103795 1018047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008131-T01-IM5 2724294 2583115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-13-1501-01 1474878 1398577 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51855038 COSM70574 99442965 c.3491A>G p.Q1164R Substitution - Missense het 38 7:55205475-55205475 + - PATHOGENIC .95786 Confirmed somatic variant 21720365 331 NS primary 50 ENSP00000275493.2:p.Gln1164Arg ENST00000275493.6:c.3491A>G 7:g.55205475A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 915621 915621 833020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014893 surgery - NOS NS 55 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 915621 915621 833020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 16014893 surgery - NOS NS 55 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1140656 1140656 1053104 lung NS NS NS carcinoma giant_cell_carcinoma NS NS n COSM26137 178380447 c.? p.T847A Substitution - Missense + - Confirmed somatic variant 19238633 surgery-fixed metastasis 44 EGFR ENST00000275493.6 3633 3236 LC_C22 1863703 1754594 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51767386 COSM18423 99393803 c.2500G>T p.V834L Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .9903 Confirmed somatic variant 22975805 surgery fresh/frozen primary 73 ENSP00000275493.2:p.Val834Leu ENST00000275493.6:c.2500G>T 7:g.55191749G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-2565 2108006 1985867 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 LC_C22 1863703 1754594 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-05-4382-01 1780053 1684052 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99288202 COSM7821254 132568282 c.1498G>C p.E500Q Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9875 Confirmed somatic variant 417 fresh/frozen - NOS primary 68 ENSP00000395243.3:p.Glu500Gln ENST00000454757.6:c.1498G>C 7:g.55163734G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876592 2876592 2731107 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 133216269 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 45 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2254T>A 7:g.55181398T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876592 2876592 2731107 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 45 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1312393 1312393 1223302 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 63 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DU-8162-01 2194248 2062526 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 61 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-05-4382-01 1780053 1684052 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99288189 COSM7821080 132568200 c.530G>T p.R177L Substitution - Missense 38 7:55152582-55152582 + - PATHOGENIC .99698 Confirmed somatic variant 417 fresh/frozen - NOS primary 68 ENSP00000395243.3:p.Arg177Leu ENST00000454757.6:c.530G>T 7:g.55152582G>T EGFR ENST00000275493.6 3633 3236 TCGA-FP-7829-01 2198081 2066359 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51829933 COSM3881812 99400168 c.971G>A p.R324H Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .95186 Confirmed somatic variant 541 NS NS 69 ENSP00000275493.2:p.Arg324His ENST00000275493.6:c.971G>A 7:g.55155911G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM_IV-39 2354294 2218452 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51778955 COSM4967262 132567096 c.545C>A p.S182Y Substitution - Missense 38 7:55152597-55152597 + - NEUTRAL .32595 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000395243.3:p.Ser182Tyr ENST00000454757.6:c.545C>A 7:g.55152597C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002599-T01-IM3 2718855 2577676 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51832234 COSM6923248 132605064 c.1397C>A p.S466Y Substitution - Missense het 38 7:55161532-55161532 + - PATHOGENIC .99176 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ser466Tyr ENST00000454757.6:c.1397C>A 7:g.55161532C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812091 2812091 2668555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 79 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006588-T01-IM5 2722965 2581786 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2811986 2811986 2668504 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 57 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152764 2152764 2021774 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MTP18_T1 2875797 2730359 pancreas NS NS NS other dysplasia-in_situ_neoplasm NS NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 32796935 surgery-fixed NS 74 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PM01T 2653315 2513442 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS primary 48.07 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2591451 2591451 2452411 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591451 2591451 2452411 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152791 2152791 2021801 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G HTR3E_ENST00000335304 ENST00000335304.6 1416 24005 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105899663 COSM10012911 103534052 c.553C>A p.P185T Substitution - Missense 38 3:184104905-184104905 + - PATHOGENIC .98714 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000335511.2:p.Pro185Thr ENST00000335304.6:c.553C>A 3:g.184104905C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007896-T01-IM5 2724107 2582928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-E1-A7YM-01 2457423 2320260 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 63 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206774 1206774 1118652 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-HT-A61C-01 2386268 2249100 central_nervous_system brain NS NS glioma NS NS NS y COSV51768130 COSM21684 132551880 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 545 NS primary 66 ENSP00000395243.3:p.Thr218Pro ENST00000454757.6:c.652A>C 7:g.55154050A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982851 982851 898570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001171-T01-IM3 2716747 2575568 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51850219 COSM6915112 133211578 c.1711G>T p.V571L Substitution - Missense het 38 7:55165403-55165403 + - PATHOGENIC .98789 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Val571Leu ENST00000455089.5:c.1711G>T 7:g.55165403G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914590 914590 832039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 71 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862448 2862448 2717613 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 31694833 circulating tumour primary 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1460126 1460126 1384003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51797094 COSM52934 99448059 c.2219T>C p.I740T Substitution - Missense 38 7:55174756-55174756 + - PATHOGENIC .99336 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000275493.2:p.Ile740Thr ENST00000275493.6:c.2219T>C 7:g.55174756T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BR-7851-01 2198108 2066386 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51815464 COSM3881829 132549983 c.2675C>T p.P892L Substitution - Missense 38 7:55198825-55198825 + - PATHOGENIC .94425 Confirmed somatic variant 541 NS NS 74 ENSP00000395243.3:p.Pro892Leu ENST00000454757.6:c.2675C>T 7:g.55198825C>T EGFR ENST00000275493.6 3633 3236 2876060 2876060 2730575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 77 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876060 2876060 2730575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 77 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003250-T01-IM5 2719745 2578566 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LIS03PT2 2053604 1933848 soft_tissue fat upper_leg NS liposarcoma myxoid-round_cell NS NS y COSV51814605 COSM1732319 132588995 c.3373C>T p.P1125S Substitution - Missense 38 7:55205492-55205492 + - PATHOGENIC .96715 Confirmed somatic variant 24190505 surgery fresh/frozen NS 41 ENSP00000395243.3:p.Pro1125Ser ENST00000454757.6:c.3373C>T 7:g.55205492C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 ORL-204 2559745 2421169 upper_aerodigestive_tract mouth buccal_mucosa NS carcinoma squamous_cell_carcinoma NS NS y COSV51826987 COSM5979347 132589098 c.3089G>A p.G1030D Substitution - Missense 38 7:55202578-55202578 + - .61156 Confirmed somatic variant 27050151 cell-line NS 76 ENSP00000395243.3:p.Gly1030Asp ENST00000454757.6:c.3089G>A 7:g.55202578G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008258-T01-IM5 2724397 2583218 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 1103794 1103794 1018046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009327-T01-IM5 2725273 2584094 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 TCGA-CV-7427-01 2193557 2061835 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99291701 COSM8368660 99397468 c.2136C>G p.F712L Substitution - Missense 38 7:55173995-55173995 + - PATHOGENIC .78822 Confirmed somatic variant 627 NS NS 73 ENSP00000275493.2:p.Phe712Leu ENST00000275493.6:c.2136C>G 7:g.55173995C>G EGFR ENST00000275493.6 3633 3236 1790522 1790522 1693501 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A-2A 2746111 2604814 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51851236 COSM7304351 99430466 c.1891C>T p.P631S Substitution - Missense 38 7:55171185-55171185 + - PATHOGENIC .97683 Confirmed somatic variant 646 NS primary 20 ENSP00000275493.2:p.Pro631Ser ENST00000275493.6:c.1891C>T 7:g.55171185C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594194 1594194 1515168 upper_aerodigestive_tract pharynx hypopharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51804843 COSM12429 133209145 c.2438_2439delinsGT p.L813R Substitution - Missense het 38 7:55191822-55191823 + - Confirmed somatic variant 19726454 surgery fresh/frozen primary 65 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438_2439delinsGT 7:g.55191822_55191823delinsGT EGFR ENST00000275493.6 3633 3236 GBM19-I2 2813466 2669858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211147 1211147 1123015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 57 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0004846-T01-IM5 2721249 2580070 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51779091 COSM2155593 99388542 c.1088C>T p.T363I Substitution - Missense het 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Thr363Ile ENST00000275493.6:c.1088C>T 7:g.55156614C>T EGFR ENST00000275493.6 3633 3236 1317181 1317181 1228082 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20126411 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-97-8177-01 2194754 2063032 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 59 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982858 982858 898577 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1078205 1078205 993455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51843665 COSM25090 133249995 c.2185G>T p.V729L Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .97108 Confirmed somatic variant 17626639 surgery-fixed primary ENSP00000415559.1:p.Val729Leu ENST00000455089.5:c.2185G>T 7:g.55181329G>T EGFR ENST00000275493.6 3633 3236 P-0008300-T01-IM5 2724426 2583247 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2690592 2690592 2549567 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSM6904574 178391321 c.? p.A1201V Substitution - Missense + - Confirmed somatic variant 28921573 surgery-fixed primary 46 ENSP00000275493.2:p.Ala1201Val EGFR ENST00000275493.6 3633 3236 LC_S35 1863746 1754637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 22975805 surgery fresh/frozen primary 82 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 LC_S35 1863746 1754637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 82 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0000580-T01-IM3 2715559 2574380 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0014258-T01-IM6 2803906 2660656 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51826193 COSM7340403 99392671 c.458A>G p.N153S Substitution - Missense het 38 7:55146639-55146639 + - PATHOGENIC .99355 Confirmed somatic variant 29316426 surgery-fixed primary 69 ENSP00000275493.2:p.Asn153Ser ENST00000275493.6:c.458A>G 7:g.55146639A>G EGFR ENST00000275493.6 3633 3236 P-0003062-T01-IM3 2719258 2578079 skin NS NS NS malignant_melanoma NS NS NS n COSV51832266 COSM6926001 99399159 c.3409G>A p.E1137K Substitution - Missense het 38 7:55205393-55205393 + - PATHOGENIC .98342 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Glu1137Lys ENST00000275493.6:c.3409G>A 7:g.55205393G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005127-T02-IM5 2721531 2580352 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51800313 COSM5608354 132549848 c.2137G>A p.E713K Substitution - Missense het 38 7:55174809-55174809 + - PATHOGENIC .99476 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Glu713Lys ENST00000454757.6:c.2137G>A 7:g.55174809G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005127-T02-IM5 2721531 2580352 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51802355 COSM6941144 132549822 c.1019C>T p.P340L Substitution - Missense het 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Pro340Leu ENST00000454757.6:c.1019C>T 7:g.55156779C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005127-T02-IM5 2721531 2580352 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51794869 COSM4362780 132549800 c.439C>T p.P147S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Pro147Ser ENST00000454757.6:c.439C>T 7:g.55151308C>T EGFR ENST00000275493.6 3633 3236 P-0000580-T01-IM3 2715559 2574380 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-D8-A1JF-01 1900052 1788736 breast NS NS NS carcinoma NS NS NS y COSV51781835 COSM174732 99379122 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 414 fresh/frozen - NOS primary 79 ENSP00000275493.2:p.Glu114Lys ENST00000275493.6:c.340G>A 7:g.55143404G>A EGFR ENST00000275493.6 3633 3236 2876656 2876656 2731171 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 surgery-fixed NS 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812110 2812110 2668565 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 31534501 pleural effusion NS 73 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A C2CD2 ENST00000380486.3 2091 1266 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105882773 COSM10012964 115630008 c.1313G>T p.S438I Substitution - Missense 38 21:41906997-41906997 - - PATHOGENIC .80898 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000369853.3:p.Ser438Ile ENST00000380486.3:c.1313G>T 21:g.41906997C>A EGFR ENST00000275493.6 3633 3236 TCGA-97-A4M7-01 2194880 2063158 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876040 2876040 2730555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 99385331 c.2153T>A p.L718Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Confirmed somatic variant 29506987 circulating tumour recurrent 66 ENSP00000275493.2:p.Leu718Gln ENST00000275493.6:c.2153T>A 7:g.55174012T>A EGFR ENST00000275493.6 3633 3236 2876040 2876040 2730555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-2565 2108006 1985867 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194722 1194722 1106617 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51824149 COSM29338 132550275 c.178G>C p.V60L Substitution - Missense 38 7:55142375-55142375 + - PATHOGENIC .98023 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Val60Leu ENST00000454757.6:c.178G>C 7:g.55142375G>C EGFR ENST00000275493.6 3633 3236 P-0003222-T01-IM5 2719716 2578537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51841941 COSM6927106 99377611 c.846G>T p.E282D Substitution - Missense het 38 7:55154109-55154109 + - NEUTRAL .06117 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000275493.2:p.Glu282Asp ENST00000275493.6:c.846G>T 7:g.55154109G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T62 2658356 2518515 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51784231 COSM3639757 132556505 c.2890G>A p.D964N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 27149842 NS NS 73.75 ENSP00000395243.3:p.Asp964Asn ENST00000454757.6:c.2890G>A 7:g.55201266G>A EGFR ENST00000275493.6 3633 3236 1312383 1312383 1223292 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 50 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-19-1789 2108040 1985901 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51850088 COSM2156010 99402616 c.1000C>T p.R334C Substitution - Missense 38 7:55155940-55155940 + - PATHOGENIC .91604 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Arg334Cys ENST00000275493.6:c.1000C>T 7:g.55155940C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-05-4382-01 1780053 1684052 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99288189 COSM7821080 133225219 c.530G>T p.R177L Substitution - Missense 38 7:55152582-55152582 + - PATHOGENIC .99698 Confirmed somatic variant 417 fresh/frozen - NOS primary 68 ENSP00000415559.1:p.Arg177Leu ENST00000455089.5:c.530G>T 7:g.55152582G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S00833_1 2480822 2343567 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV51796349 COSM317275 132567852 c.1792A>G p.I598V Substitution - Missense 38 7:55172990-55172990 + - PATHOGENIC .91771 Confirmed somatic variant 26168399 surgery fresh/frozen primary 77 ENSP00000395243.3:p.Ile598Val ENST00000454757.6:c.1792A>G 7:g.55172990A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010613-T01-IM5 2726312 2585133 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1505372 1505372 1428248 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DU-8162-01 2194248 2062526 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 61 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM_IV-39 2354294 2218452 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51778955 COSM4967262 133223756 c.545C>A p.S182Y Substitution - Missense 38 7:55152597-55152597 + - NEUTRAL .32595 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000415559.1:p.Ser182Tyr ENST00000455089.5:c.545C>A 7:g.55152597C>A EGFR ENST00000275493.6 3633 3236 2591387 2591387 2452347 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM3718342 178387182 c.? p.S752F Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Ser752Phe EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Padua023 2406690 2269570 thymus NS NS NS thymoma mixed_lymphoepithelial NS NS n COSV51787507 COSM13188 132557864 c.2146G>A p.D716N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Confirmed somatic variant 24974848 surgery fresh/frozen NS 75 ENSP00000395243.3:p.Asp716Asn ENST00000454757.6:c.2146G>A 7:g.55174818G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002599-T01-IM3 2718855 2577676 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51832234 COSM6923248 133269701 c.1397C>A p.S466Y Substitution - Missense het 38 7:55161532-55161532 + - PATHOGENIC .99176 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ser466Tyr ENST00000455089.5:c.1397C>A 7:g.55161532C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-05-4382-01 1780053 1684052 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99288202 COSM7821254 133225235 c.1498G>C p.E500Q Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9875 Confirmed somatic variant 417 fresh/frozen - NOS primary 68 ENSP00000415559.1:p.Glu500Gln ENST00000455089.5:c.1498G>C 7:g.55163734G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812091 2812091 2668555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 79 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1468645 1468645 1392396 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0006399-T01-IM5 2722775 2581596 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843352 COSM6950555 99413778 c.530C>T p.S177L Substitution - Missense het 38 7:55146711-55146711 + - NEUTRAL .28714 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Ser177Leu ENST00000275493.6:c.530C>T 7:g.55146711C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206761 1206761 1118639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206761 1206761 1118639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003107-T01-IM5 2719603 2578424 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003107-T01-IM5 2719603 2578424 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2811953 2811953 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 31534501 circulating tumour NS 69 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2811953 2811953 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 99378740 c.2582T>G p.L861R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 31534501 circulating tumour NS 69 ENSP00000275493.2:p.Leu861Arg ENST00000275493.6:c.2582T>G 7:g.55191831T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006588-T01-IM5 2722965 2581786 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206720 1206720 1118598 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003128-T01-IM5 2719622 2578443 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982855 982855 898574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PM01T 2653315 2513442 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS primary 48.07 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-02-0003 2107930 1985791 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51809225 COSM35825 99407038 c.1859G>A p.C620Y Substitution - Missense 38 7:55165416-55165416 + - PATHOGENIC .99893 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Cys620Tyr ENST00000275493.6:c.1859G>A 7:g.55165416G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152791 2152791 2021801 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-E1-A7YM-01 2457423 2320260 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 63 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489258 1489258 1412416 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 40 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206774 1206774 1118652 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-HT-A61C-01 2386268 2249100 central_nervous_system brain NS NS glioma NS NS NS y COSV51768130 COSM21684 133206822 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 545 NS primary 66 ENSP00000415559.1:p.Thr218Pro ENST00000455089.5:c.652A>C 7:g.55154050A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006171-T01-IM5 2722550 2581371 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812092 2812092 2668556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 59 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1170506 1170506 1082640 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 19117057 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 81 898381 815993 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914590 914590 832039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 71 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0000906-T01-IM3 2716233 2575054 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765787 COSM2149971 99378201 c.910C>T p.H304Y Substitution - Missense het 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.His304Tyr ENST00000275493.6:c.910C>T 7:g.55155850C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BR-7851-01 2198108 2066386 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51815464 COSM3881829 133204910 c.2675C>T p.P892L Substitution - Missense 38 7:55198825-55198825 + - PATHOGENIC .94425 Confirmed somatic variant 541 NS NS 74 ENSP00000415559.1:p.Pro892Leu ENST00000455089.5:c.2675C>T 7:g.55198825C>T EGFR ENST00000275493.6 3633 3236 P-0009215-T01-IM5 2725184 2584005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LICA-CN-HCC089T 2634136 2494532 liver NS NS NS other neoplasm NS NS y COSV51832020 COSM5822378 99409409 c.1742A>T p.Q581L Substitution - Missense 38 7:55165299-55165299 + - PATHOGENIC .9451 Confirmed somatic variant 660 NS primary 48 ENSP00000275493.2:p.Gln581Leu ENST00000275493.6:c.1742A>T 7:g.55165299A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000628-T02-IM5 2719366 2578187 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876660 2876660 2731175 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 53 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 ORL-204 2559745 2421169 upper_aerodigestive_tract mouth buccal_mucosa NS carcinoma squamous_cell_carcinoma NS NS y COSV51826987 COSM5979347 133250857 c.3089G>A p.G1030D Substitution - Missense 38 7:55202578-55202578 + - .61156 Confirmed somatic variant 27050151 cell-line NS 76 ENSP00000415559.1:p.Gly1030Asp ENST00000455089.5:c.3089G>A 7:g.55202578G>A EGFR ENST00000275493.6 3633 3236 TCGA-19-1790-01 2120301 1994537 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51799291 COSM3412201 99377407 c.2419G>C p.D807H Substitution - Missense 38 7:55181428-55181428 + - PATHOGENIC .97226 Confirmed somatic variant 329 NS NS 56 ENSP00000275493.2:p.Asp807His ENST00000275493.6:c.2419G>C 7:g.55181428G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206713 1206713 1118591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001613-T01-IM3 2717641 2576462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001613-T01-IM3 2717641 2576462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009327-T01-IM5 2725273 2584094 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 TCGA-QH-A6CX-01 2263100 2130084 central_nervous_system brain NS NS glioma NS NS NS y COSV51785554 COSM21688 99375522 c.971G>T p.R324L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 545 NS primary 66 ENSP00000275493.2:p.Arg324Leu ENST00000275493.6:c.971G>T 7:g.55155911G>T EGFR ENST00000275493.6 3633 3236 1489252 1489252 1412410 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 59 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-AO-A12G-01 1899795 1788479 breast NS NS NS carcinoma NS NS NS y COSV51772564 COSM453241 99398102 c.817A>G p.T273A Substitution - Missense 38 7:55154080-55154080 + - PATHOGENIC .94785 Confirmed somatic variant 414 fresh/frozen - NOS primary 75 ENSP00000275493.2:p.Thr273Ala ENST00000275493.6:c.817A>G 7:g.55154080A>G EGFR ENST00000275493.6 3633 3236 MSU3-a 2809972 2666634 large_intestine colon transverse NS adenoma tubulovillous NS NS y COSV99292326 COSM9176305 99406722 c.1579C>T p.R527W Substitution - Missense 38 7:55161579-55161579 + - NEUTRAL .28879 Confirmed somatic variant 26336987 surgery fresh/frozen primary 51 ENSP00000275493.2:p.Arg527Trp ENST00000275493.6:c.1579C>T 7:g.55161579C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005127-T02-IM5 2721531 2580352 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51794869 COSM4362780 133204758 c.439C>T p.P147S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Pro147Ser ENST00000455089.5:c.439C>T 7:g.55151308C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005127-T02-IM5 2721531 2580352 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51800313 COSM5608354 133204795 c.2137G>A p.E713K Substitution - Missense het 38 7:55174809-55174809 + - PATHOGENIC .99476 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Glu713Lys ENST00000455089.5:c.2137G>A 7:g.55174809G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005127-T02-IM5 2721531 2580352 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51802355 COSM6941144 133204776 c.1019C>T p.P340L Substitution - Missense het 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Pro340Leu ENST00000455089.5:c.1019C>T 7:g.55156779C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011541-T01-IM5 2727113 2585934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2014_Lung_sq_25_T 2744896 2603599 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 74 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 YUKAT 2439331 2302172 skin NS NS NS malignant_melanoma NS NS NS y COSV51838161 COSM5407720 132550571 c.859C>T p.P287S Substitution - Missense het 38 7:55155934-55155934 + - PATHOGENIC .91925 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 78 ENSP00000395243.3:p.Pro287Ser ENST00000454757.6:c.859C>T 7:g.55155934C>T EGFR ENST00000275493.6 3633 3236 1322234 1322234 1233121 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 41 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A021-T-S17 2757381 2615995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 57 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1103795 1103795 1018047 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Br001X 1312986 1223895 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51797037 COSM40998 132608582 c.1669G>C p.E557Q Substitution - Missense hom 38 7:55165361-55165361 + - PATHOGENIC .99549 Confirmed somatic variant 18772396 xenograft primary 4 ENSP00000395243.3:p.Glu557Gln ENST00000454757.6:c.1669G>C 7:g.55165361G>C EGFR ENST00000275493.6 3633 3236 CHG-2011-508T 2634354 2494750 liver NS NS NS other neoplasm NS NS y COSV51803297 COSM6285115 99444146 c.3323C>T p.P1108L Substitution - Missense 38 7:55205307-55205307 + - PATHOGENIC .91978 Confirmed somatic variant 660 NS primary 70 ENSP00000275493.2:p.Pro1108Leu ENST00000275493.6:c.3323C>T 7:g.55205307C>T EGFR ENST00000275493.6 3633 3236 P-0008131-T01-IM5 2724294 2583115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 915621 915621 833020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014893 surgery - NOS NS 55 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 915621 915621 833020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 16014893 surgery - NOS NS 55 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T62 2658356 2518515 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51784231 COSM3639757 133212507 c.2890G>A p.D964N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 27149842 NS NS 73.75 ENSP00000415559.1:p.Asp964Asn ENST00000455089.5:c.2890G>A 7:g.55201266G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194722 1194722 1106617 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51824149 COSM29338 133205167 c.178G>C p.V60L Substitution - Missense 38 7:55142375-55142375 + - PATHOGENIC .98023 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Val60Leu ENST00000455089.5:c.178G>C 7:g.55142375G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CHC1598T 2341018 2206001 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51828039 COSM4788935 132590158 c.2329G>C p.A777P Substitution - Missense 38 7:55181473-55181473 + - PATHOGENIC .97736 Confirmed somatic variant 381 NS primary 76 ENSP00000395243.3:p.Ala777Pro ENST00000454757.6:c.2329G>C 7:g.55181473G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S00833_1 2480822 2343567 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV51796349 COSM317275 133224623 c.1792A>G p.I598V Substitution - Missense 38 7:55172990-55172990 + - PATHOGENIC .91771 Confirmed somatic variant 26168399 surgery fresh/frozen primary 77 ENSP00000415559.1:p.Ile598Val ENST00000455089.5:c.1792A>G 7:g.55172990A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010613-T01-IM5 2726312 2585133 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 2876592 2876592 2731107 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 99388191 c.2389T>A p.C797S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 45 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2389T>A 7:g.55181398T>A EGFR ENST00000275493.6 3633 3236 2876592 2876592 2731107 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 45 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BR-4184-01 2198083 2066361 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51787507 COSM13188 132557864 c.2146G>A p.D716N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Confirmed somatic variant 541 NS NS 70 ENSP00000395243.3:p.Asp716Asn ENST00000454757.6:c.2146G>A 7:g.55174818G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1505372 1505372 1428248 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Padua023 2406690 2269570 thymus NS NS NS thymoma mixed_lymphoepithelial NS NS n COSV51787507 COSM13188 133213942 c.2146G>A p.D716N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Confirmed somatic variant 24974848 surgery fresh/frozen NS 75 ENSP00000415559.1:p.Asp716Asn ENST00000455089.5:c.2146G>A 7:g.55174818G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206761 1206761 1118639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206761 1206761 1118639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-C5-A2M2-01 2193383 2061661 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51773844 COSM1451620 132588127 c.3154G>A p.V1052I Substitution - Missense 38 7:55205273-55205273 + - NEUTRAL .13302 Confirmed somatic variant 415 NS NS 56 ENSP00000395243.3:p.Val1052Ile ENST00000454757.6:c.3154G>A 7:g.55205273G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003107-T01-IM5 2719603 2578424 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003107-T01-IM5 2719603 2578424 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TARGET-30-PAVDBS-01A-01D 2746863 2605566 autonomic_ganglia NS NS NS neuroblastoma NS NS NS y COSV51826171 COSM7252952 132563671 c.1789A>G p.K597E Substitution - Missense 38 7:55172987-55172987 + - PATHOGENIC .94412 Confirmed somatic variant 584 NS primary 3 ENSP00000395243.3:p.Lys597Glu ENST00000454757.6:c.1789A>G 7:g.55172987A>G EGFR ENST00000275493.6 3633 3236 MTP18_T1 2875797 2730359 pancreas NS NS NS other dysplasia-in_situ_neoplasm NS NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 32796935 surgery-fixed NS 74 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-ER-A19E-06 2121716 1995952 skin NS NS NS malignant_melanoma NS NS NS y COSV51817262 COSM3639733 132602028 c.820G>A p.E274K Substitution - Missense 38 7:55155895-55155895 + - PATHOGENIC .99356 Confirmed somatic variant 540 NS NS 36 ENSP00000395243.3:p.Glu274Lys ENST00000454757.6:c.820G>A 7:g.55155895G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-VM-A8CD-01 2262980 2129964 central_nervous_system brain NS NS glioma NS NS NS y COSV99295978 COSM8269849 132579423 c.1612G>T p.A538S Substitution - Missense 38 7:55165304-55165304 + - PATHOGENIC .98882 Confirmed somatic variant 545 NS primary 58 ENSP00000395243.3:p.Ala538Ser ENST00000454757.6:c.1612G>T 7:g.55165304G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-VM-A8CD-01 2262980 2129964 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS primary 58 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206720 1206720 1118598 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003128-T01-IM5 2719622 2578443 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EXTERN_MELA_20140924_029 2839375 2695141 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51765811 COSM3639748 132552757 c.2074A>G p.K692E Substitution - Missense 38 7:55174746-55174746 + - PATHOGENIC .92243 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000395243.3:p.Lys692Glu ENST00000454757.6:c.2074A>G 7:g.55174746A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458691 1458691 1382666 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-MP-A4T9-01 2194742 2063020 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 G-2A 2746114 2604817 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51788082 COSM7293955 99406705 c.3353C>T p.A1118V Substitution - Missense 38 7:55205337-55205337 + - NEUTRAL .26149 Confirmed somatic variant 646 NS primary 23 ENSP00000275493.2:p.Ala1118Val ENST00000275493.6:c.3353C>T 7:g.55205337C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982855 982855 898574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1468629 1468629 1392380 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0007896-T01-IM5 2724107 2582928 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GHE0415 2491107 2353753 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm diffuse_large_B_cell_lymphoma NS NS y COSV51842912 COSM5713652 132595470 c.2608T>C p.Y870H Substitution - Missense 38 7:55198758-55198758 + - PATHOGENIC .98173 Confirmed somatic variant 26608593 NS recurrent ENSP00000395243.3:p.Tyr870His ENST00000454757.6:c.2608T>C 7:g.55198758T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CH-LA6 2211432 2079635 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24449147 surgery fresh/frozen NS 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1010433 1010433 927607 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 17001163 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1070 2472300 2335070 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51770694 COSM20891 132562677 c.2251G>A p.G751S Substitution - Missense 38 7:55181395-55181395 + - PATHOGENIC .98244 Confirmed somatic variant 25669975 surgery fresh/frozen primary ENSP00000395243.3:p.Gly751Ser ENST00000454757.6:c.2251G>A 7:g.55181395G>A EGFR ENST00000275493.6 3633 3236 982851 982851 898570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1498499 1498499 1421377 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21040950 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0001171-T01-IM3 2716747 2575568 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51850219 COSM6915112 99382971 c.1846G>T p.V616L Substitution - Missense het 38 7:55165403-55165403 + - PATHOGENIC .98789 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Val616Leu ENST00000275493.6:c.1846G>T 7:g.55165403G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1909613 1909613 1798132 oesophagus NS NS NS carcinoma carcinosarcoma NS NS n COSV51773932 COSM1272071 132568328 c.2233A>G p.T745A Substitution - Missense 38 7:55181377-55181377 + - PATHOGENIC .9793 Confirmed somatic variant 23546020 fixed - NOS NS ENSP00000395243.3:p.Thr745Ala ENST00000454757.6:c.2233A>G 7:g.55181377A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2156363 2156363 2025373 lung right_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 24752053 surgery - NOS primary 48 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005021 1005021 922233 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005021 1005021 922233 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489258 1489258 1412416 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 40 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0003250-T01-IM5 2719745 2578566 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51792433 COSM6966446 132577379 c.1627G>A p.G543S Substitution - Missense het 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly543Ser ENST00000454757.6:c.1627G>A 7:g.55165319G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 P-0008258-T01-IM5 2724397 2583218 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006171-T01-IM5 2722550 2581371 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 16740 1423712 1333740 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812092 2812092 2668556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 59 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S001090 1027692 944668 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5315 915994 833393 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 182 898386 815998 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S25 2393062 2255893 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S25 2393062 2255893 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51840622 COSM5044867 132600271 c.2530A>G p.R844G Substitution - Missense 38 7:55192805-55192805 + - PATHOGENIC .75709 Confirmed somatic variant 25189529 surgery fresh/frozen NS 73 ENSP00000395243.3:p.Arg844Gly ENST00000454757.6:c.2530A>G 7:g.55192805A>G EGFR ENST00000275493.6 3633 3236 1594194 1594194 1515168 upper_aerodigestive_tract pharynx hypopharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51804843 COSM12429 99380902 c.2573_2574delinsGT p.L858R Substitution - Missense het 38 7:55191822-55191823 + - Confirmed somatic variant 19726454 surgery fresh/frozen primary 65 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573_2574delinsGT 7:g.55191822_55191823delinsGT EGFR ENST00000275493.6 3633 3236 1211147 1211147 1123015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 57 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000628-T02-IM5 2719366 2578187 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812123 2812123 2668571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-97-8177-01 2194754 2063032 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 59 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1078205 1078205 993455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51843665 COSM25090 99426133 c.2320G>T p.V774L Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .97108 Confirmed somatic variant 17626639 surgery-fixed primary ENSP00000275493.2:p.Val774Leu ENST00000275493.6:c.2320G>T 7:g.55181329G>T EGFR ENST00000275493.6 3633 3236 2812110 2812110 2668565 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 31534501 pleural effusion NS 73 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-14-1034-01 2178234 2046532 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51775191 COSM1451530 132550172 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 329 NS NS 60 ENSP00000395243.3:p.Gly63Arg ENST00000454757.6:c.187G>A 7:g.55142384G>A EGFR ENST00000275493.6 3633 3236 TCGA-BR-7851-01 2198108 2066386 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51815464 COSM3881829 99376770 c.2810C>T p.P937L Substitution - Missense 38 7:55198825-55198825 + - PATHOGENIC .94425 Confirmed somatic variant 541 NS NS 74 ENSP00000275493.2:p.Pro937Leu ENST00000275493.6:c.2810C>T 7:g.55198825C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876660 2876660 2731175 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 53 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206713 1206713 1118591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5346 915995 833394 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001613-T01-IM3 2717641 2576462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001613-T01-IM3 2717641 2576462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 165 898385 815997 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-06-2565 2108006 1985867 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 1091695 1091695 1006517 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM26132 178386036 c.? p.Y727H Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 TCGA-DU-8162-01 2194248 2062526 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 61 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 TCGA-05-4382-01 1780053 1684052 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99288202 COSM7821254 99400050 c.1633G>C p.E545Q Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9875 Confirmed somatic variant 417 fresh/frozen - NOS primary 68 ENSP00000275493.2:p.Glu545Gln ENST00000275493.6:c.1633G>C 7:g.55163734G>C EGFR ENST00000275493.6 3633 3236 GBM_IV-39 2354294 2218452 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51778955 COSM4967262 99398277 c.680C>A p.S227Y Substitution - Missense 38 7:55152597-55152597 + - NEUTRAL .32595 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000275493.2:p.Ser227Tyr ENST00000275493.6:c.680C>A 7:g.55152597C>A EGFR ENST00000275493.6 3633 3236 2115508 2115508 1989752 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0002599-T01-IM3 2718855 2577676 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51832234 COSM6923248 99446293 c.1532C>A p.S511Y Substitution - Missense het 38 7:55161532-55161532 + - PATHOGENIC .99176 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ser511Tyr ENST00000275493.6:c.1532C>A 7:g.55161532C>A EGFR ENST00000275493.6 3633 3236 TCGA-05-4382-01 1780053 1684052 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99288189 COSM7821080 99400025 c.665G>T p.R222L Substitution - Missense 38 7:55152582-55152582 + - PATHOGENIC .99698 Confirmed somatic variant 417 fresh/frozen - NOS primary 68 ENSP00000275493.2:p.Arg222Leu ENST00000275493.6:c.665G>T 7:g.55152582G>T EGFR ENST00000275493.6 3633 3236 2812091 2812091 2668555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 79 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0006588-T01-IM5 2722965 2581786 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011541-T01-IM5 2727113 2585934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 4140 915991 833390 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AA-3542-01 1650994 1565781 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51833841 COSM291998 132586317 c.2168G>C p.S723T Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98756 Confirmed somatic variant 22810696 376 NS NS 69 ENSP00000395243.3:p.Ser723Thr ENST00000454757.6:c.2168G>C 7:g.55181312G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005895-T01-IM5 2722277 2581098 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 NS metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 13T 2139248 2008776 upper_aerodigestive_tract mouth gingiva NS carcinoma squamous_cell_carcinoma NS NS y COSV51815394 COSM3715755 132556509 c.603C>A p.S201R Substitution - Missense 38 7:55152655-55152655 + - NEUTRAL .15461 Confirmed somatic variant 24292195 NS NS ENSP00000395243.3:p.Ser201Arg ENST00000454757.6:c.603C>A 7:g.55152655C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Br230T 1313049 1223958 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 surgery - NOS primary 46 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2167073 2167073 2035392 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 24926557 surgery-fixed NS 50 ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1044287 1044287 960628 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 PM01T 2653315 2513442 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS primary 48.07 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2766021 2766021 2624255 breast NS NS NS carcinoma HER-positive_carcinoma NS NS n COSM6503280 178380263 c.? p.K846R Substitution - Missense + - Confirmed somatic variant 30023006 surgery-fixed NS ENSP00000275493.2:p.Lys846Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Br001X 1312986 1223895 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51797037 COSM40998 133273127 c.1669G>C p.E557Q Substitution - Missense hom 38 7:55165361-55165361 + - PATHOGENIC .99549 Confirmed somatic variant 18772396 xenograft primary 4 ENSP00000415559.1:p.Glu557Gln ENST00000455089.5:c.1669G>C 7:g.55165361G>C EGFR ENST00000275493.6 3633 3236 2152791 2152791 2021801 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CHC1598T 2341018 2206001 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51828039 COSM4788935 133252189 c.2329G>C p.A777P Substitution - Missense 38 7:55181473-55181473 + - PATHOGENIC .97736 Confirmed somatic variant 381 NS primary 76 ENSP00000415559.1:p.Ala777Pro ENST00000455089.5:c.2329G>C 7:g.55181473G>C EGFR ENST00000275493.6 3633 3236 TCGA-E1-A7YM-01 2457423 2320260 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 63 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1206774 1206774 1118652 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-CG-5721-01 2198017 2066295 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51782832 COSM3881808 132578587 c.604G>A p.D202N Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .98807 Confirmed somatic variant 541 NS NS 58 ENSP00000395243.3:p.Asp202Asn ENST00000454757.6:c.604G>A 7:g.55152656G>A EGFR ENST00000275493.6 3633 3236 TCGA-HT-A61C-01 2386268 2249100 central_nervous_system brain NS NS glioma NS NS NS y COSV51768130 COSM21684 99378725 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 545 NS primary 66 ENSP00000275493.2:p.Thr263Pro ENST00000275493.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005400-T01-IM5 2721802 2580623 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51781835 COSM174732 132552286 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Glu114Lys ENST00000454757.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EXTERN_MELA_20140924_029 2839375 2695141 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51765811 COSM3639748 133207801 c.2074A>G p.K692E Substitution - Missense 38 7:55174746-55174746 + - PATHOGENIC .92243 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000415559.1:p.Lys692Glu ENST00000455089.5:c.2074A>G 7:g.55174746A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1044286 1044286 960627 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009357-T01-IM5 2725300 2584121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009357-T01-IM5 2725300 2584121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 914590 914590 832039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 71 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0012404-T01-IM5 2727460 2586281 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51802403 COSM6984779 132570882 c.2168_2170delinsTCC p.S723_V724delinsIL Substitution - Missense het 38 7:55181312-55181314 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ser723_Val724delinsIleLeu ENST00000454757.6:c.2168_2170delinsTCC 7:g.55181312_55181314delinsTCC EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BR-4184-01 2198083 2066361 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51787507 COSM13188 133213942 c.2146G>A p.D716N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Confirmed somatic variant 541 NS NS 70 ENSP00000415559.1:p.Asp716Asn ENST00000455089.5:c.2146G>A 7:g.55174818G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD25645c 2843020 2698474 skin mucosal sinonasal NS malignant_melanoma NS NS NS y COSV104576411 COSM9505912 132618214 c.746A>T p.K249M Substitution - Missense 38 7:55154144-55154144 + - PATHOGENIC .88176 Confirmed somatic variant 30664638 surgery-fixed primary 58 ENSP00000395243.3:p.Lys249Met ENST00000454757.6:c.746A>T 7:g.55154144A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-ER-A19E-06 2121716 1995952 skin NS NS NS malignant_melanoma NS NS NS y COSV51817262 COSM3639733 133266194 c.820G>A p.E274K Substitution - Missense 38 7:55155895-55155895 + - PATHOGENIC .99356 Confirmed somatic variant 540 NS NS 36 ENSP00000415559.1:p.Glu274Lys ENST00000455089.5:c.820G>A 7:g.55155895G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 4 1489411 1412569 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21102258 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1322241 1322241 1233128 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 59 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TARGET-30-PAVDBS-01A-01D 2746863 2605566 autonomic_ganglia NS NS NS neuroblastoma NS NS NS y COSV51826171 COSM7252952 133219999 c.1789A>G p.K597E Substitution - Missense 38 7:55172987-55172987 + - PATHOGENIC .94412 Confirmed somatic variant 584 NS primary 3 ENSP00000415559.1:p.Lys597Glu ENST00000455089.5:c.1789A>G 7:g.55172987A>G EGFR ENST00000275493.6 3633 3236 ORL-204 2559745 2421169 upper_aerodigestive_tract mouth buccal_mucosa NS carcinoma squamous_cell_carcinoma NS NS y COSV51826987 COSM5979347 99427416 c.3224G>A p.G1075D Substitution - Missense 38 7:55202578-55202578 + - .61156 Confirmed somatic variant 27050151 cell-line NS 76 ENSP00000275493.2:p.Gly1075Asp ENST00000275493.6:c.3224G>A 7:g.55202578G>A EGFR ENST00000275493.6 3633 3236 LIS03PT2 2053604 1933848 soft_tissue fat upper_leg NS liposarcoma myxoid-round_cell NS NS y COSV51814605 COSM1732319 99427291 c.3508C>T p.P1170S Substitution - Missense 38 7:55205492-55205492 + - PATHOGENIC .96715 Confirmed somatic variant 24190505 surgery fresh/frozen NS 41 ENSP00000275493.2:p.Pro1170Ser ENST00000275493.6:c.3508C>T 7:g.55205492C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-VM-A8CD-01 2262980 2129964 central_nervous_system brain NS NS glioma NS NS NS y COSV99295978 COSM8269849 133240286 c.1612G>T p.A538S Substitution - Missense 38 7:55165304-55165304 + - PATHOGENIC .98882 Confirmed somatic variant 545 NS primary 58 ENSP00000415559.1:p.Ala538Ser ENST00000455089.5:c.1612G>T 7:g.55165304G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-VM-A8CD-01 2262980 2129964 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS primary 58 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 YUKAT 2439331 2302172 skin NS NS NS malignant_melanoma NS NS NS y COSV51838161 COSM5407720 133205436 c.859C>T p.P287S Substitution - Missense het 38 7:55155934-55155934 + - PATHOGENIC .91925 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 78 ENSP00000415559.1:p.Pro287Ser ENST00000455089.5:c.859C>T 7:g.55155934C>T EGFR ENST00000275493.6 3633 3236 1170504 1170504 1082638 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 19117057 surgery fresh/frozen primary 82 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458691 1458691 1382666 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-MP-A4T9-01 2194742 2063020 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A065-T-S30 2757406 2616000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0009327-T01-IM5 2725273 2584094 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KD921 1005017 922229 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765252 COSM13009 132568674 c.1991A>G p.E664G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Glu664Gly ENST00000454757.6:c.1991A>G 7:g.55173985A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KD921 1005017 922229 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009527-T01-IM5 2725444 2584265 skin NS NS NS malignant_melanoma NS NS NS n COSV51794946 COSM6969229 132549011 c.353_354delinsTT p.A118V Substitution - Missense het 38 7:55143417-55143418 + - Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ala118Val ENST00000454757.6:c.353_354delinsTT 7:g.55143417_55143418delinsTT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-22-4609-01 2195227 2063505 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51827895 COSM3412174 132552248 c.550A>T p.S184C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 418 NS NS 81 ENSP00000395243.3:p.Ser184Cys ENST00000454757.6:c.550A>T 7:g.55152602A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GHE0415 2491107 2353753 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm diffuse_large_B_cell_lymphoma NS NS y COSV51842912 COSM5713652 133258646 c.2608T>C p.Y870H Substitution - Missense 38 7:55198758-55198758 + - PATHOGENIC .98173 Confirmed somatic variant 26608593 NS recurrent ENSP00000415559.1:p.Tyr870His ENST00000455089.5:c.2608T>C 7:g.55198758T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471557 1471557 1395296 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CH-LA6 2211432 2079635 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24449147 surgery fresh/frozen NS 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-77-8156-01 2195103 2063381 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99294239 COSM8763918 132566475 c.3278A>G p.Y1093C Substitution - Missense 38 7:55205397-55205397 + - PATHOGENIC .98303 Confirmed somatic variant 418 NS NS 60 ENSP00000395243.3:p.Tyr1093Cys ENST00000454757.6:c.3278A>G 7:g.55205397A>G EGFR ENST00000275493.6 3633 3236 P-0005127-T02-IM5 2721531 2580352 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51802355 COSM6941144 99376606 c.1154C>T p.P385L Substitution - Missense het 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Pro385Leu ENST00000275493.6:c.1154C>T 7:g.55156779C>T EGFR ENST00000275493.6 3633 3236 P-0005127-T02-IM5 2721531 2580352 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51794869 COSM4362780 99376586 c.574C>T p.P192S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Pro192Ser ENST00000275493.6:c.574C>T 7:g.55151308C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1070 2472300 2335070 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51770694 COSM20891 133218993 c.2251G>A p.G751S Substitution - Missense 38 7:55181395-55181395 + - PATHOGENIC .98244 Confirmed somatic variant 25669975 surgery fresh/frozen primary ENSP00000415559.1:p.Gly751Ser ENST00000455089.5:c.2251G>A 7:g.55181395G>A EGFR ENST00000275493.6 3633 3236 P-0005127-T02-IM5 2721531 2580352 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51800313 COSM5608354 99376626 c.2272G>A p.E758K Substitution - Missense het 38 7:55174809-55174809 + - PATHOGENIC .99476 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Glu758Lys ENST00000275493.6:c.2272G>A 7:g.55174809G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1909613 1909613 1798132 oesophagus NS NS NS carcinoma carcinosarcoma NS NS n COSV51773932 COSM1272071 133225284 c.2233A>G p.T745A Substitution - Missense 38 7:55181377-55181377 + - PATHOGENIC .9793 Confirmed somatic variant 23546020 fixed - NOS NS ENSP00000415559.1:p.Thr745Ala ENST00000455089.5:c.2233A>G 7:g.55181377A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2156363 2156363 2025373 lung right_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 24752053 surgery - NOS primary 48 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005021 1005021 922233 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005021 1005021 922233 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51792433 COSM6966446 133237386 c.1627G>A p.G543S Substitution - Missense het 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly543Ser ENST00000455089.5:c.1627G>A 7:g.55165319G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005002 1005002 922214 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 T62 2658356 2518515 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51784231 COSM3639757 99383908 c.3025G>A p.D1009N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 27149842 NS NS 73.75 ENSP00000275493.2:p.Asp1009Asn ENST00000275493.6:c.3025G>A 7:g.55201266G>A EGFR ENST00000275493.6 3633 3236 1194722 1194722 1106617 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51824149 COSM29338 99377163 c.178G>C p.V60L Substitution - Missense 38 7:55142375-55142375 + - PATHOGENIC .98023 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Val60Leu ENST00000275493.6:c.178G>C 7:g.55142375G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876605 2876605 2731120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 132563558 c.2239C>T p.L747F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour NS 43 ENSP00000395243.3:p.Leu747Phe ENST00000454757.6:c.2239C>T 7:g.55181383C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876605 2876605 2731120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 132563564 c.2240T>A p.L747H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Confirmed somatic variant 29506987 circulating tumour NS 43 ENSP00000395243.3:p.Leu747His ENST00000454757.6:c.2240T>A 7:g.55181384T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876605 2876605 2731120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 43 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876605 2876605 2731120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 132563575 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 43 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2255G>C 7:g.55181399G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 16740 1423712 1333740 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 S00833_1 2480822 2343567 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV51796349 COSM317275 99399523 c.1927A>G p.I643V Substitution - Missense 38 7:55172990-55172990 + - PATHOGENIC .91771 Confirmed somatic variant 26168399 surgery fresh/frozen primary 77 ENSP00000275493.2:p.Ile643Val ENST00000275493.6:c.1927A>G 7:g.55172990A>G EGFR ENST00000275493.6 3633 3236 P-0010613-T01-IM5 2726312 2585133 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S001090 1027692 944668 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5315 915994 833393 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876041 2876041 2730556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 43 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1505372 1505372 1428248 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011262-T01-IM5 2726872 2585693 endometrium NS NS NS carcinoma mixed_cell_carcinoma NS NS n COSV51803408 COSM6979939 132554256 c.1843G>A p.V615M Substitution - Missense het 38 7:55173041-55173041 + - PATHOGENIC .71586 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Val615Met ENST00000454757.6:c.1843G>A 7:g.55173041G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 182 898386 815998 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S25 2393062 2255893 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S25 2393062 2255893 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51840622 COSM5044867 133264364 c.2530A>G p.R844G Substitution - Missense 38 7:55192805-55192805 + - PATHOGENIC .75709 Confirmed somatic variant 25189529 surgery fresh/frozen NS 73 ENSP00000415559.1:p.Arg844Gly ENST00000455089.5:c.2530A>G 7:g.55192805A>G EGFR ENST00000275493.6 3633 3236 Padua023 2406690 2269570 thymus NS NS NS thymoma mixed_lymphoepithelial NS NS n COSV51787507 COSM13188 99385457 c.2281G>A p.D761N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Confirmed somatic variant 24974848 surgery fresh/frozen NS 75 ENSP00000275493.2:p.Asp761Asn ENST00000275493.6:c.2281G>A 7:g.55174818G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812123 2812123 2668571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TG74187 2823154 2679008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM9274128 178383270 c.? p.L11F Substitution - Missense + - Confirmed somatic variant 28818608 surgery-fixed NS 56 EGFR ENST00000275493.6 3633 3236 P-0003107-T01-IM5 2719603 2578424 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 P-0003107-T01-IM5 2719603 2578424 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1206761 1206761 1118639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206761 1206761 1118639 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 896927 896927 814550 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206720 1206720 1118598 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0003128-T01-IM5 2719622 2578443 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005257 1005257 922469 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51807094 COSM20893 132564889 c.2387G>A p.R796K Substitution - Missense 38 7:55191771-55191771 + - PATHOGENIC .98912 Confirmed somatic variant 16720329 surgery-fixed primary 71 ENSP00000395243.3:p.Arg796Lys ENST00000454757.6:c.2387G>A 7:g.55191771G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-14-1034-01 2178234 2046532 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51775191 COSM1451530 133205080 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 329 NS NS 60 ENSP00000415559.1:p.Gly63Arg ENST00000455089.5:c.187G>A 7:g.55142384G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5346 915995 833394 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982855 982855 898574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1109719 1109719 1023629 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 18372921 surgery-fixed primary 81 ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 165 898385 815997 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1109719 1109719 1023629 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51788343 COSM18441 132609147 c.2019_2020delinsTT p.G674C Substitution - Missense het 38 7:55174013-55174014 + - Confirmed somatic variant 18372921 surgery-fixed primary 81 ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2019_2020delinsTT 7:g.55174013_55174014delinsTT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458677 1458677 1382652 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2115505 2115505 1989749 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1489258 1489258 1412416 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 40 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0006171-T01-IM5 2722550 2581371 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2812092 2812092 2668556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 59 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2115515 2115515 1989759 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AZ-6599-01 1651173 1565960 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51797242 COSM1451615 132577733 c.2542C>T p.H848Y Substitution - Missense 38 7:55192817-55192817 + - PATHOGENIC .94682 Confirmed somatic variant 376 NS NS 72 ENSP00000395243.3:p.His848Tyr ENST00000454757.6:c.2542C>T 7:g.55192817C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 4140 915991 833390 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AA-3542-01 1650994 1565781 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51833841 COSM291998 133247915 c.2168G>C p.S723T Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98756 Confirmed somatic variant 22810696 376 NS NS 69 ENSP00000415559.1:p.Ser723Thr ENST00000455089.5:c.2168G>C 7:g.55181312G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005895-T01-IM5 2722277 2581098 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 NS metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0000628-T02-IM5 2719366 2578187 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Br230T 1313049 1223958 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 surgery - NOS primary 46 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004104-T01-IM5 2720505 2579326 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51846321 COSM6933335 132607120 c.1773T>G p.C591W Substitution - Missense het 38 7:55171202-55171202 + - .63273 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Cys591Trp ENST00000454757.6:c.1773T>G 7:g.55171202T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 13T 2139248 2008776 upper_aerodigestive_tract mouth gingiva NS carcinoma squamous_cell_carcinoma NS NS y COSV51815394 COSM3715755 133212513 c.603C>A p.S201R Substitution - Missense 38 7:55152655-55152655 + - NEUTRAL .15461 Confirmed somatic variant 24292195 NS NS ENSP00000415559.1:p.Ser201Arg ENST00000455089.5:c.603C>A 7:g.55152655C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2167073 2167073 2035392 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 24926557 surgery-fixed NS 50 ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1044287 1044287 960628 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876660 2876660 2731175 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 53 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FS-A1ZK-06 2121762 1995998 skin NS NS NS malignant_melanoma NS NS NS y COSV51790737 COSM3639739 132597151 c.1486C>T p.L496F Substitution - Missense 38 7:55161621-55161621 + - NEUTRAL .0484 Confirmed somatic variant 540 NS NS 68 ENSP00000395243.3:p.Leu496Phe ENST00000454757.6:c.1486C>T 7:g.55161621C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194727 1194727 1106622 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1206713 1206713 1118591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0001613-T01-IM3 2717641 2576462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 P-0001613-T01-IM3 2717641 2576462 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2675064 2675064 2534339 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 29110836 surgery-fixed recurrent 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2115506 2115506 1989750 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-CG-5721-01 2198017 2066295 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51782832 COSM3881808 133239031 c.604G>A p.D202N Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .98807 Confirmed somatic variant 541 NS NS 58 ENSP00000415559.1:p.Asp202Asn ENST00000455089.5:c.604G>A 7:g.55152656G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1044286 1044286 960627 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471552 1471552 1395291 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 YUKAT 2439331 2302172 skin NS NS NS malignant_melanoma NS NS NS y COSV51838161 COSM5407720 99377471 c.994C>T p.P332S Substitution - Missense het 38 7:55155934-55155934 + - PATHOGENIC .91925 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 78 ENSP00000275493.2:p.Pro332Ser ENST00000275493.6:c.994C>T 7:g.55155934C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005400-T01-IM5 2721802 2580623 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51781835 COSM174732 133207258 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Glu114Lys ENST00000455089.5:c.340G>A 7:g.55143404G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 WGC003566 2785058 2645174 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS y COSV51806564 COSM6920868 132555861 c.1871G>A p.R624Q Substitution - Missense 38 7:55173069-55173069 + - PATHOGENIC .99699 Confirmed somatic variant 25526346 surgery fresh/frozen primary 54 ENSP00000395243.3:p.Arg624Gln ENST00000454757.6:c.1871G>A 7:g.55173069G>A EGFR ENST00000275493.6 3633 3236 P-0011541-T01-IM5 2727113 2585934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009357-T01-IM5 2725300 2584121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009357-T01-IM5 2725300 2584121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0012404-T01-IM5 2727460 2586281 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51802403 COSM6984779 133228592 c.2168_2170delinsTCC p.S723_V724delinsIL Substitution - Missense het 38 7:55181312-55181314 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ser723_Val724delinsIleLeu ENST00000455089.5:c.2168_2170delinsTCC 7:g.55181312_55181314delinsTCC EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD25645c 2843020 2698474 skin mucosal sinonasal NS malignant_melanoma NS NS NS y COSV104576411 COSM9505912 133281464 c.746A>T p.K249M Substitution - Missense 38 7:55154144-55154144 + - PATHOGENIC .88176 Confirmed somatic variant 30664638 surgery-fixed primary 58 ENSP00000415559.1:p.Lys249Met ENST00000455089.5:c.746A>T 7:g.55154144A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S02249_1 2480880 2343625 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV51799414 COSM5680213 132566990 c.3364C>G p.L1122V Substitution - Missense 38 7:55205483-55205483 + - PATHOGENIC .88717 Confirmed somatic variant 26168399 surgery fresh/frozen primary 74 ENSP00000395243.3:p.Leu1122Val ENST00000454757.6:c.3364C>G 7:g.55205483C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 4 1489411 1412569 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21102258 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1322241 1322241 1233128 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 59 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-26-1439 2108054 1985915 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206770 1206770 1118648 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-BR-4184-01 2198083 2066361 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51787507 COSM13188 99385457 c.2281G>A p.D761N Substitution - Missense 38 7:55174818-55174818 + - PATHOGENIC .99476 Confirmed somatic variant 541 NS NS 70 ENSP00000275493.2:p.Asp761Asn ENST00000275493.6:c.2281G>A 7:g.55174818G>A EGFR ENST00000275493.6 3633 3236 Br001X 1312986 1223895 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51797037 COSM40998 99450000 c.1804G>C p.E602Q Substitution - Missense hom 38 7:55165361-55165361 + - PATHOGENIC .99549 Confirmed somatic variant 18772396 xenograft primary 4 ENSP00000275493.2:p.Glu602Gln ENST00000275493.6:c.1804G>C 7:g.55165361G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 658 898392 816004 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004980 1004980 922192 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1113111 1113111 1026612 thymus NS NS NS thymoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18448188 surgery-fixed NS 65 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-GN-A8LN-01 2339478 2204461 skin NS NS NS malignant_melanoma NS NS NS y COSV99295991 COSM7976081 132576442 c.1000G>A p.D334N Substitution - Missense 38 7:55156760-55156760 + - PATHOGENIC .99676 Confirmed somatic variant 540 NS primary 68 ENSP00000395243.3:p.Asp334Asn ENST00000454757.6:c.1000G>A 7:g.55156760G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-GN-A8LN-01 2339478 2204461 skin NS NS NS malignant_melanoma NS NS NS y COSV99295987 COSM7976353 132576431 c.680C>T p.P227L Substitution - Missense 38 7:55154078-55154078 + - PATHOGENIC .98876 Confirmed somatic variant 540 NS primary 68 ENSP00000395243.3:p.Pro227Leu ENST00000454757.6:c.680C>T 7:g.55154078C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PCA1897 2861532 2716771 prostate NS NS NS carcinoma NS NS NS n COSV51777202 COSM20896 132585150 c.2365G>A p.V789M Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .98912 Confirmed somatic variant 32268276 circulating tumour NS ENSP00000395243.3:p.Val789Met ENST00000454757.6:c.2365G>A 7:g.55191749G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CLL107 1897543 1786227 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51791822 COSM1292529 132579921 c.3190G>A p.V1064I Substitution - Missense 38 7:55205309-55205309 + - .63125 Confirmed somatic variant 23415222 blood-bone marrow NS ENSP00000395243.3:p.Val1064Ile ENST00000454757.6:c.3190G>A 7:g.55205309G>A EGFR ENST00000275493.6 3633 3236 CHC1598T 2341018 2206001 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51828039 COSM4788935 99428760 c.2464G>C p.A822P Substitution - Missense 38 7:55181473-55181473 + - PATHOGENIC .97736 Confirmed somatic variant 381 NS primary 76 ENSP00000275493.2:p.Ala822Pro ENST00000275493.6:c.2464G>C 7:g.55181473G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A065-T-S30 2757406 2616000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KD921 1005017 922229 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KD921 1005017 922229 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765252 COSM13009 133225791 c.1991A>G p.E664G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Glu664Gly ENST00000455089.5:c.1991A>G 7:g.55173985A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2492702 2492702 2355317 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 132569945 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000395243.3:p.His47Tyr ENST00000454757.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009346-T01-IM5 2725290 2584111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009527-T01-IM5 2725444 2584265 skin NS NS NS malignant_melanoma NS NS NS n COSV51794946 COSM6969229 133203968 c.353_354delinsTT p.A118V Substitution - Missense het 38 7:55143417-55143418 + - Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ala118Val ENST00000455089.5:c.353_354delinsTT 7:g.55143417_55143418delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-22-4609-01 2195227 2063505 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51827895 COSM3412174 133207223 c.550A>T p.S184C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 418 NS NS 81 ENSP00000415559.1:p.Ser184Cys ENST00000455089.5:c.550A>T 7:g.55152602A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471557 1471557 1395296 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-BR-4184-01 2198083 2066361 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51818237 COSM122787 99420630 c.534G>T p.M178I Substitution - Missense 38 7:55146715-55146715 + - PATHOGENIC .7306 Confirmed somatic variant 541 NS NS 70 ENSP00000275493.2:p.Met178Ile ENST00000275493.6:c.534G>T 7:g.55146715G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0747-01 1337860 1248245 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 53 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 TCGA-ER-A19E-06 2121716 1995952 skin NS NS NS malignant_melanoma NS NS NS y COSV51817262 COSM3639733 99442874 c.955G>A p.E319K Substitution - Missense 38 7:55155895-55155895 + - PATHOGENIC .99356 Confirmed somatic variant 540 NS NS 36 ENSP00000275493.2:p.Glu319Lys ENST00000275493.6:c.955G>A 7:g.55155895G>A EGFR ENST00000275493.6 3633 3236 TCGA-C5-A2M2-01 2193383 2061661 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51773844 COSM1451620 99425810 c.3289G>A p.V1097I Substitution - Missense 38 7:55205273-55205273 + - NEUTRAL .13302 Confirmed somatic variant 415 NS NS 56 ENSP00000275493.2:p.Val1097Ile ENST00000275493.6:c.3289G>A 7:g.55205273G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LICA-CN-HCC048T 2634095 2494491 liver NS NS NS other neoplasm NS NS y COSV51841658 COSM5820522 132604732 c.2611G>A p.D871N Substitution - Missense 38 7:55198761-55198761 + - PATHOGENIC .9794 Confirmed somatic variant 660 NS primary 54 ENSP00000395243.3:p.Asp871Asn ENST00000454757.6:c.2611G>A 7:g.55198761G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002309-T01-IM3 2718596 2577417 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TARGET-30-PAVDBS-01A-01D 2746863 2605566 autonomic_ganglia NS NS NS neuroblastoma NS NS NS y COSV51826171 COSM7252952 99392649 c.1924A>G p.K642E Substitution - Missense 38 7:55172987-55172987 + - PATHOGENIC .94412 Confirmed somatic variant 584 NS primary 3 ENSP00000275493.2:p.Lys642Glu ENST00000275493.6:c.1924A>G 7:g.55172987A>G EGFR ENST00000275493.6 3633 3236 TCGA-VM-A8CD-01 2262980 2129964 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS primary 58 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 TCGA-VM-A8CD-01 2262980 2129964 central_nervous_system brain NS NS glioma NS NS NS y COSV99295978 COSM8269849 99414153 c.1747G>T p.A583S Substitution - Missense 38 7:55165304-55165304 + - PATHOGENIC .98882 Confirmed somatic variant 545 NS primary 58 ENSP00000275493.2:p.Ala583Ser ENST00000275493.6:c.1747G>T 7:g.55165304G>T EGFR ENST00000275493.6 3633 3236 1458691 1458691 1382666 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T341 2658331 2518490 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51784286 COSM6652281 132555792 c.116C>T p.T39M Substitution - Missense 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 27149842 NS NS 66.58 ENSP00000395243.3:p.Thr39Met ENST00000454757.6:c.116C>T 7:g.55142313C>T EGFR ENST00000275493.6 3633 3236 TCGA-MP-A4T9-01 2194742 2063020 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 17228 1423804 1333832 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 EXTERN_MELA_20140924_029 2839375 2695141 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51765811 COSM3639748 99379625 c.2209A>G p.K737E Substitution - Missense 38 7:55174746-55174746 + - PATHOGENIC .92243 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000275493.2:p.Lys737Glu ENST00000275493.6:c.2209A>G 7:g.55174746A>G EGFR ENST00000275493.6 3633 3236 GHE0415 2491107 2353753 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm diffuse_large_B_cell_lymphoma NS NS y COSV51842912 COSM5713652 99435725 c.2743T>C p.Y915H Substitution - Missense 38 7:55198758-55198758 + - PATHOGENIC .98173 Confirmed somatic variant 26608593 NS recurrent ENSP00000275493.2:p.Tyr915His ENST00000275493.6:c.2743T>C 7:g.55198758T>C EGFR ENST00000275493.6 3633 3236 1498498 1498498 1421376 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21040950 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 CH-LA6 2211432 2079635 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24449147 surgery fresh/frozen NS 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460149 1460149 1384026 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920026 920026 837105 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 56 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002488-T01-IM3 2718760 2577581 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-CV-7250-01 2193784 2062062 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51827895 COSM3412174 132552248 c.550A>T p.S184C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 627 NS NS 64 ENSP00000395243.3:p.Ser184Cys ENST00000454757.6:c.550A>T 7:g.55152602A>T EGFR ENST00000275493.6 3633 3236 1070 2472300 2335070 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51770694 COSM20891 99391373 c.2386G>A p.G796S Substitution - Missense 38 7:55181395-55181395 + - PATHOGENIC .98244 Confirmed somatic variant 25669975 surgery fresh/frozen primary ENSP00000275493.2:p.Gly796Ser ENST00000275493.6:c.2386G>A 7:g.55181395G>A EGFR ENST00000275493.6 3633 3236 1909613 1909613 1798132 oesophagus NS NS NS carcinoma carcinosarcoma NS NS n COSV51773932 COSM1272071 99400111 c.2368A>G p.T790A Substitution - Missense 38 7:55181377-55181377 + - PATHOGENIC .9793 Confirmed somatic variant 23546020 fixed - NOS NS ENSP00000275493.2:p.Thr790Ala ENST00000275493.6:c.2368A>G 7:g.55181377A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812122 2812122 2668571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010004-T01-IM5 2725823 2584644 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 2862436 2862436 2717607 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 31694833 circulating tumour metastasis 47 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2862436 2862436 2717607 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM9583352 178381889 c.? p.Q791R Substitution - Missense + - Confirmed somatic variant 31694833 circulating tumour metastasis 47 EGFR ENST00000275493.6 3633 3236 2156363 2156363 2025373 lung right_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 24752053 surgery - NOS primary 48 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1005021 1005021 922233 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 1005021 1005021 922233 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51792433 COSM6966446 99410412 c.1762G>A p.G588S Substitution - Missense het 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly588Ser ENST00000275493.6:c.1762G>A 7:g.55165319G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1063625 1063625 979670 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G FRY_ENST00000647500 ENST00000647500.1 9177 20367 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105932591 COSM10012802 178303826 c.2104G>A p.D702N Substitution - Missense 38 13:32171088-32171088 + - PATHOGENIC .96279 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000494761.1:p.Asp702Asn ENST00000647500.1:c.2104G>A 13:g.32171088G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876036 2876036 2730551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 132548474 c.2117C>T p.T706I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Confirmed somatic variant 29506987 NS recurrent 62 ENSP00000395243.3:p.Thr706Ile ENST00000454757.6:c.2117C>T 7:g.55174789C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876036 2876036 2730551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 62 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1595811 1595811 1516608 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51837721 COSM133589 132574829 c.2479G>A p.E827K Substitution - Missense hom 38 7:55191863-55191863 + - PATHOGENIC .98912 Confirmed somatic variant 16551849 surgery-fixed NS 41 ENSP00000395243.3:p.Glu827Lys ENST00000454757.6:c.2479G>A 7:g.55191863G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982874 982874 898593 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 W16T 2745047 2603750 thyroid NS NS NS carcinoma NS NS NS y COSV51794993 COSM6399094 132564700 c.5G>A p.R2Q Substitution - Missense 38 7:55019282-55019282 + - NEUTRAL .46409 Confirmed somatic variant 676 NS primary 40 ENSP00000395243.3:p.Arg2Gln ENST00000454757.6:c.5G>A 7:g.55019282G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005002 1005002 922214 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2011-2283:2012-316-T 2297701 2163302 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51817351 COSM3881830 132566658 c.2957G>A p.R986Q Substitution - Missense hom 38 7:55201333-55201333 + - PATHOGENIC .98371 Confirmed somatic variant 25056374 surgery-fixed NS ENSP00000395243.3:p.Arg986Gln ENST00000454757.6:c.2957G>A 7:g.55201333G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2011-2283:2012-316-T 2297701 2163302 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51817336 COSM4604310 132596353 c.1241G>C p.G414A Substitution - Missense hom 38 7:55160216-55160216 + - PATHOGENIC .99469 Confirmed somatic variant 25056374 surgery-fixed NS ENSP00000395243.3:p.Gly414Ala ENST00000454757.6:c.1241G>C 7:g.55160216G>C EGFR ENST00000275493.6 3633 3236 16740 1423712 1333740 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000390-T01-IM3 2715182 2574003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 S001090 1027692 944668 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 5315 915994 833393 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876605 2876605 2731120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 133219834 c.2239C>T p.L747F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour NS 43 ENSP00000415559.1:p.Leu747Phe ENST00000455089.5:c.2239C>T 7:g.55181383C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876605 2876605 2731120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 133219858 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 43 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2255G>C 7:g.55181399G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876605 2876605 2731120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 43 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876605 2876605 2731120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 133219841 c.2240T>A p.L747H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Confirmed somatic variant 29506987 circulating tumour NS 43 ENSP00000415559.1:p.Leu747His ENST00000455089.5:c.2240T>A 7:g.55181384T>A EGFR ENST00000275493.6 3633 3236 182 898386 815998 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 S25 2393062 2255893 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51840622 COSM5044867 99441200 c.2665A>G p.R889G Substitution - Missense 38 7:55192805-55192805 + - PATHOGENIC .75709 Confirmed somatic variant 25189529 surgery fresh/frozen NS 73 ENSP00000275493.2:p.Arg889Gly ENST00000275493.6:c.2665A>G 7:g.55192805A>G EGFR ENST00000275493.6 3633 3236 S25 2393062 2255893 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-S9-A7R2-01 2263272 2130256 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 69 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876041 2876041 2730556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 43 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011262-T01-IM5 2726872 2585693 endometrium NS NS NS carcinoma mixed_cell_carcinoma NS NS n COSV51803408 COSM6979939 133209587 c.1843G>A p.V615M Substitution - Missense het 38 7:55173041-55173041 + - PATHOGENIC .71586 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Val615Met ENST00000455089.5:c.1843G>A 7:g.55173041G>A EGFR ENST00000275493.6 3633 3236 2812123 2812123 2668571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211132 1211132 1123000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 69 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-14-1034-01 2178234 2046532 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51775191 COSM1451530 99377057 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 329 NS NS 60 ENSP00000275493.2:p.Gly63Arg ENST00000275493.6:c.187G>A 7:g.55142384G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 896927 896927 814550 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489263 1489263 1412421 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 86566 1520669 1443044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20668451 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2857119 2857119 2712419 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV105110043 COSM9533927 132585707 c.175G>A p.E59K Substitution - Missense 38 7:55142372-55142372 + - PATHOGENIC .93877 Confirmed somatic variant 25096233 surgery - NOS NS ENSP00000395243.3:p.Glu59Lys ENST00000454757.6:c.175G>A 7:g.55142372G>A EGFR ENST00000275493.6 3633 3236 5346 915995 833394 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 165 898385 815997 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005257 1005257 922469 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51807094 COSM20893 133221314 c.2387G>A p.R796K Substitution - Missense 38 7:55191771-55191771 + - PATHOGENIC .98912 Confirmed somatic variant 16720329 surgery-fixed primary 71 ENSP00000415559.1:p.Arg796Lys ENST00000455089.5:c.2387G>A 7:g.55191771G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 897282 897282 814905 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15118073 surgery fresh/frozen primary 45 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-QB-AA9O-06 2339489 2204472 skin NS NS NS malignant_melanoma NS NS NS y COSV51785510 COSM6957413 132547201 c.967G>A p.D323N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 540 NS NS 73 ENSP00000395243.3:p.Asp323Asn ENST00000454757.6:c.967G>A 7:g.55156628G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-81-5910-01 2120398 1994634 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 132553689 c.619C>T p.R207C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 NS NS 64 ENSP00000395243.3:p.Arg207Cys ENST00000454757.6:c.619C>T 7:g.55154017C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1109719 1109719 1023629 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51788343 COSM18441 133273681 c.2019_2020delinsTT p.G674C Substitution - Missense het 38 7:55174013-55174014 + - Confirmed somatic variant 18372921 surgery-fixed primary 81 ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2019_2020delinsTT 7:g.55174013_55174014delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1109719 1109719 1023629 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 18372921 surgery-fixed primary 81 ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811943 2811943 2668490 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 55 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152797 2152797 2021807 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489253 1489253 1412411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1498502 1498502 1421380 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21040950 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1010442 1010442 927616 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM21348 178379157 c.? p.P753F Substitution - Missense + - Confirmed somatic variant 17001163 surgery fresh/frozen primary EGFR ENST00000275493.6 3633 3236 4140 915991 833390 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458677 1458677 1382652 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-AA-3542-01 1650994 1565781 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51833841 COSM291998 99423508 c.2303G>C p.S768T Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98756 Confirmed somatic variant 22810696 376 NS NS 69 ENSP00000275493.2:p.Ser768Thr ENST00000275493.6:c.2303G>C 7:g.55181312G>C EGFR ENST00000275493.6 3633 3236 P-0005895-T01-IM5 2722277 2581098 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 NS metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 Br230T 1313049 1223958 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 surgery - NOS primary 46 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 20-2 2746109 2604812 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51794834 COSM5575633 132558496 c.2738G>A p.R913H Substitution - Missense 38 7:55200340-55200340 + - PATHOGENIC .99504 Confirmed somatic variant 646 NS primary 59 ENSP00000395243.3:p.Arg913His ENST00000454757.6:c.2738G>A 7:g.55200340G>A EGFR ENST00000275493.6 3633 3236 1044287 1044287 960628 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 13T 2139248 2008776 upper_aerodigestive_tract mouth gingiva NS carcinoma squamous_cell_carcinoma NS NS y COSV51815394 COSM3715755 99383912 c.738C>A p.S246R Substitution - Missense 38 7:55152655-55152655 + - NEUTRAL .15461 Confirmed somatic variant 24292195 NS NS ENSP00000275493.2:p.Ser246Arg ENST00000275493.6:c.738C>A 7:g.55152655C>A EGFR ENST00000275493.6 3633 3236 2167073 2167073 2035392 lung left NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 24926557 surgery-fixed NS 50 ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2823203 2823203 2679056 lung left_lower_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29074208 surgery - NOS primary 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2823203 2823203 2679056 lung left_lower_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51766509 COSM5945664 132563575 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + - PATHOGENIC .98511 Confirmed somatic variant 29074208 surgery - NOS primary 75 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2255G>C 7:g.55181399G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AZ-6599-01 1651173 1565960 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51797242 COSM1451615 133237860 c.2542C>T p.H848Y Substitution - Missense 38 7:55192817-55192817 + - PATHOGENIC .94682 Confirmed somatic variant 376 NS NS 72 ENSP00000415559.1:p.His848Tyr ENST00000455089.5:c.2542C>T 7:g.55192817C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458692 1458692 1382667 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001582-T01-IM3 2717588 2576409 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769747 COSM297803 132576756 c.772G>C p.D258H Substitution - Missense het 38 7:55155847-55155847 + - PATHOGENIC .99461 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Asp258His ENST00000454757.6:c.772G>C 7:g.55155847G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S001092 1027684 944660 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005007 1005007 922219 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2733978 2733978 2592705 soft_tissue fat NS NS liposarcoma NS NS NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 29731991 surgery-fixed recurrent ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004104-T01-IM5 2720505 2579326 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51846321 COSM6933335 133271699 c.1773T>G p.C591W Substitution - Missense het 38 7:55171202-55171202 + - .63273 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Cys591Trp ENST00000455089.5:c.1773T>G 7:g.55171202T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2492721 2492721 2355336 skin NS NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 132556505 c.2890G>A p.D964N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000395243.3:p.Asp964Asn ENST00000454757.6:c.2890G>A 7:g.55201266G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 B42-S1 2732496 2591261 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV104576683 COSM9498592 132574370 c.823G>C p.E275Q Substitution - Missense 38 7:55155898-55155898 + - PATHOGENIC .98914 Confirmed somatic variant 29244145 surgery fresh/frozen primary 70.1 ENSP00000395243.3:p.Glu275Gln ENST00000454757.6:c.823G>C 7:g.55155898G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194727 1194727 1106622 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1044286 1044286 960627 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0005400-T01-IM5 2721802 2580623 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51781835 COSM174732 99379122 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Glu114Lys ENST00000275493.6:c.340G>A 7:g.55143404G>A EGFR ENST00000275493.6 3633 3236 TCGA-CG-5721-01 2198017 2066295 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51782832 COSM3881808 99412645 c.739G>A p.D247N Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .98807 Confirmed somatic variant 541 NS NS 58 ENSP00000275493.2:p.Asp247Asn ENST00000275493.6:c.739G>A 7:g.55152656G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003529-T01-IM5 2720010 2578831 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51803297 COSM6285115 132603213 c.3188C>T p.P1063L Substitution - Missense het 38 7:55205307-55205307 + - PATHOGENIC .91978 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Pro1063Leu ENST00000454757.6:c.3188C>T 7:g.55205307C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152775 2152775 2021785 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0009357-T01-IM5 2725300 2584121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 P-0009357-T01-IM5 2725300 2584121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0012404-T01-IM5 2727460 2586281 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51802403 COSM6984779 99402877 c.2303_2305delinsTCC p.S768_V769delinsIL Substitution - Missense het 38 7:55181312-55181314 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ser768_Val769delinsIleLeu ENST00000275493.6:c.2303_2305delinsTCC 7:g.55181312_55181314delinsTCC EGFR ENST00000275493.6 3633 3236 PD25645c 2843020 2698474 skin mucosal sinonasal NS malignant_melanoma NS NS NS y COSV104576411 COSM9505912 99457300 c.881A>T p.K294M Substitution - Missense 38 7:55154144-55154144 + - PATHOGENIC .88176 Confirmed somatic variant 30664638 surgery-fixed primary 58 ENSP00000275493.2:p.Lys294Met ENST00000275493.6:c.881A>T 7:g.55154144A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FS-A1ZK-06 2121762 1995998 skin NS NS NS malignant_melanoma NS NS NS y COSV51790737 COSM3639739 133260744 c.1486C>T p.L496F Substitution - Missense 38 7:55161621-55161621 + - NEUTRAL .0484 Confirmed somatic variant 540 NS NS 68 ENSP00000415559.1:p.Leu496Phe ENST00000455089.5:c.1486C>T 7:g.55161621C>T EGFR ENST00000275493.6 3633 3236 4 1489411 1412569 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21102258 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2115503 2115503 1989747 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1322241 1322241 1233128 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 59 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1063623 1063623 979668 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 85 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471552 1471552 1395291 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 573-72 2605265 2466156 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 25376516 surgery - NOS NS 69 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 WGC003566 2785058 2645174 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS y COSV51806564 COSM6920868 133211798 c.1871G>A p.R624Q Substitution - Missense 38 7:55173069-55173069 + - PATHOGENIC .99699 Confirmed somatic variant 25526346 surgery fresh/frozen primary 54 ENSP00000415559.1:p.Arg624Gln ENST00000455089.5:c.1871G>A 7:g.55173069G>A EGFR ENST00000275493.6 3633 3236 1516754 1516754 1439348 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21575252 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010554-T01-IM5 2726255 2585076 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A065-T-S30 2757406 2616000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 KD921 1005017 922229 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765252 COSM13009 99400543 c.2126A>G p.E709G Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97508 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Glu709Gly ENST00000275493.6:c.2126A>G 7:g.55173985A>G EGFR ENST00000275493.6 3633 3236 KD921 1005017 922229 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-22-4609-01 2195227 2063505 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51827895 COSM3412174 99379092 c.685A>T p.S229C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 418 NS NS 81 ENSP00000275493.2:p.Ser229Cys ENST00000275493.6:c.685A>T 7:g.55152602A>T EGFR ENST00000275493.6 3633 3236 P-0009527-T01-IM5 2725444 2584265 skin NS NS NS malignant_melanoma NS NS NS n COSV51794946 COSM6969229 99375677 c.353_354delinsTT p.A118V Substitution - Missense het 38 7:55143417-55143418 + - Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ala118Val ENST00000275493.6:c.353_354delinsTT 7:g.55143417_55143418delinsTT EGFR ENST00000275493.6 3633 3236 1471557 1471557 1395296 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DD282_Org 2749235 2607934 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51784286 COSM6652281 132555792 c.116C>T p.T39M Substitution - Missense het 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 29703791 organoid culture primary 81 ENSP00000395243.3:p.Thr39Met ENST00000454757.6:c.116C>T 7:g.55142313C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-26-1439 2108054 1985915 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206770 1206770 1118648 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004980 1004980 922192 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-77-8156-01 2195103 2063381 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99294239 COSM8763918 99397174 c.3413A>G p.Y1138C Substitution - Missense 38 7:55205397-55205397 + - PATHOGENIC .98303 Confirmed somatic variant 418 NS NS 60 ENSP00000275493.2:p.Tyr1138Cys ENST00000275493.6:c.3413A>G 7:g.55205397A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1113111 1113111 1026612 thymus NS NS NS thymoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18448188 surgery-fixed NS 65 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 658 898392 816004 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-GN-A8LN-01 2339478 2204461 skin NS NS NS malignant_melanoma NS NS NS y COSV99295991 COSM7976081 133236066 c.1000G>A p.D334N Substitution - Missense 38 7:55156760-55156760 + - PATHOGENIC .99676 Confirmed somatic variant 540 NS primary 68 ENSP00000415559.1:p.Asp334Asn ENST00000455089.5:c.1000G>A 7:g.55156760G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-GN-A8LN-01 2339478 2204461 skin NS NS NS malignant_melanoma NS NS NS y COSV99295987 COSM7976353 133236041 c.680C>T p.P227L Substitution - Missense 38 7:55154078-55154078 + - PATHOGENIC .98876 Confirmed somatic variant 540 NS primary 68 ENSP00000415559.1:p.Pro227Leu ENST00000455089.5:c.680C>T 7:g.55154078C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PCA1897 2861532 2716771 prostate NS NS NS carcinoma NS NS NS n COSV51777202 COSM20896 133246500 c.2365G>A p.V789M Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .98912 Confirmed somatic variant 32268276 circulating tumour NS ENSP00000415559.1:p.Val789Met ENST00000455089.5:c.2365G>A 7:g.55191749G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1468099 1468099 1391945 peritoneum NS NS NS mesothelioma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920038 920038 837117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 15623594 surgery fresh/frozen NS 63 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009346-T01-IM5 2725290 2584111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SJHGG029_R 2307362 2172566 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 24705251 surgery - NOS recurrent 4 ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0747-01 1337860 1248245 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 53 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1005002 1005002 922214 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2492702 2492702 2355317 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 133227476 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000415559.1:p.His47Tyr ENST00000455089.5:c.139C>T 7:g.55142336C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T341 2658331 2518490 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51784286 COSM6652281 133211716 c.116C>T p.T39M Substitution - Missense 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 27149842 NS NS 66.58 ENSP00000415559.1:p.Thr39Met ENST00000455089.5:c.116C>T 7:g.55142313C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1790514 1790514 1693493 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51778758 COSM707337 132556884 c.2458G>A p.E820K Substitution - Missense 38 7:55191842-55191842 + - PATHOGENIC .97736 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000395243.3:p.Glu820Lys ENST00000454757.6:c.2458G>A 7:g.55191842G>A EGFR ENST00000275493.6 3633 3236 2876605 2876605 2731120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 99392449 c.2374C>T p.L792F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour NS 43 ENSP00000275493.2:p.Leu792Phe ENST00000275493.6:c.2374C>T 7:g.55181383C>T EGFR ENST00000275493.6 3633 3236 2876605 2876605 2731120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 99392455 c.2375T>A p.L792H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Confirmed somatic variant 29506987 circulating tumour NS 43 ENSP00000275493.2:p.Leu792His ENST00000275493.6:c.2375T>A 7:g.55181384T>A EGFR ENST00000275493.6 3633 3236 2876605 2876605 2731120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 99392475 c.2390G>C p.C797S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 43 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2390G>C 7:g.55181399G>C EGFR ENST00000275493.6 3633 3236 2876605 2876605 2731120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 43 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876041 2876041 2730556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 43 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LICA-CN-HCC048T 2634095 2494491 liver NS NS NS other neoplasm NS NS y COSV51841658 COSM5820522 133269353 c.2611G>A p.D871N Substitution - Missense 38 7:55198761-55198761 + - PATHOGENIC .9794 Confirmed somatic variant 660 NS primary 54 ENSP00000415559.1:p.Asp871Asn ENST00000455089.5:c.2611G>A 7:g.55198761G>A EGFR ENST00000275493.6 3633 3236 P-0011262-T01-IM5 2726872 2585693 endometrium NS NS NS carcinoma mixed_cell_carcinoma NS NS n COSV51803408 COSM6979939 99381268 c.1978G>A p.V660M Substitution - Missense het 38 7:55173041-55173041 + - PATHOGENIC .71586 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Val660Met ENST00000275493.6:c.1978G>A 7:g.55173041G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002309-T01-IM3 2718596 2577417 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002890-T01-IM3 2719115 2577936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004988 1004988 922200 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T1196 2658782 2518941 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51797600 COSM5575629 132569532 c.391G>A p.G131R Substitution - Missense 38 7:55143455-55143455 + - PATHOGENIC .99768 Confirmed somatic variant 27149842 NS NS 70.83 ENSP00000395243.3:p.Gly131Arg ENST00000454757.6:c.391G>A 7:g.55143455G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S0388 897614 815237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15118125 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-13-0717-01 1475078 1398777 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51824273 COSM116668 132609986 c.2381C>T p.A794V Substitution - Missense het 38 7:55191765-55191765 + - PATHOGENIC .97911 Confirmed somatic variant 21720365 331 NS primary 54 ENSP00000395243.3:p.Ala794Val ENST00000454757.6:c.2381C>T 7:g.55191765C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007771-T01-IM5 2724004 2582825 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51862622 COSM6959670 132547639 c.1187T>G p.V396G Substitution - Missense het 38 7:55160162-55160162 + - PATHOGENIC .9258 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Val396Gly ENST00000454757.6:c.1187T>G 7:g.55160162T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-CD-A4MI-01 2198040 2066318 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51771322 COSM3881814 132562387 c.916A>G p.I306V Substitution - Missense 38 7:55156577-55156577 + - PATHOGENIC .89527 Confirmed somatic variant 541 NS NS 62 ENSP00000395243.3:p.Ile306Val ENST00000454757.6:c.916A>G 7:g.55156577A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008346-T01-IM5 2787024 2644447 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51838649 COSM6962468 132582557 c.412A>G p.R138G Substitution - Missense hom 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000395243.3:p.Arg138Gly ENST00000454757.6:c.412A>G 7:g.55143476A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 ccRCC-90 1980826 1867072 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51815313 COSM1661639 132586690 c.538G>T p.G180C Substitution - Missense 38 7:55152590-55152590 + - PATHOGENIC .99717 Confirmed somatic variant 23797736 NS NS ENSP00000395243.3:p.Gly180Cys ENST00000454757.6:c.538G>T 7:g.55152590G>T EGFR ENST00000275493.6 3633 3236 896927 896927 814550 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 17228 1423804 1333832 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_S50 1863766 1754657 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2777774 2777774 2635909 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSM7408753 178387928 c.? p.A118T Substitution - Missense + - Confirmed somatic variant 30041611 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2777774 2777774 2635909 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSM7408761 178387952 c.? p.R1068Q Substitution - Missense + - Confirmed somatic variant 30041611 surgery-fixed NS ENSP00000275493.2:p.Arg1068Gln EGFR ENST00000275493.6 3633 3236 2777774 2777774 2635909 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSM7408763 178387941 c.? p.S1071L Substitution - Missense + - Confirmed somatic variant 30041611 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2777774 2777774 2635909 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSM7408760 178387938 c.? p.R334H Substitution - Missense + - Confirmed somatic variant 30041611 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2777774 2777774 2635909 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSM7408762 178387950 c.? p.G1022S Substitution - Missense + - Confirmed somatic variant 30041611 surgery-fixed NS ENSP00000275493.2:p.Gly1022Ser EGFR ENST00000275493.6 3633 3236 1005257 1005257 922469 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51807094 COSM20893 99394489 c.2522G>A p.R841K Substitution - Missense 38 7:55191771-55191771 + - PATHOGENIC .98912 Confirmed somatic variant 16720329 surgery-fixed primary 71 ENSP00000275493.2:p.Arg841Lys ENST00000275493.6:c.2522G>A 7:g.55191771G>A EGFR ENST00000275493.6 3633 3236 1109719 1109719 1023629 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 18372921 surgery-fixed primary 81 ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 1109719 1109719 1023629 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51788343 COSM18441 99450460 c.2154_2155delinsTT p.G719C Substitution - Missense het 38 7:55174013-55174014 + - Confirmed somatic variant 18372921 surgery-fixed primary 81 ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2154_2155delinsTT 7:g.55174013_55174014delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460149 1460149 1384026 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920026 920026 837105 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 56 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002488-T01-IM3 2718760 2577581 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-CV-7250-01 2193784 2062062 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51827895 COSM3412174 133207223 c.550A>T p.S184C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 627 NS NS 64 ENSP00000415559.1:p.Ser184Cys ENST00000455089.5:c.550A>T 7:g.55152602A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 W16T 2745047 2603750 thyroid NS NS NS carcinoma NS NS NS y COSV51794993 COSM6399094 133221088 c.5G>A p.R2Q Substitution - Missense 38 7:55019282-55019282 + - NEUTRAL .46409 Confirmed somatic variant 676 NS primary 40 ENSP00000415559.1:p.Arg2Gln ENST00000455089.5:c.5G>A 7:g.55019282G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876658 2876658 2731173 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 80 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T3262 2296207 2161810 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51822879 COSM4680399 132555327 c.1904G>A p.R635Q Substitution - Missense 38 7:55173102-55173102 + - PATHOGENIC .99814 Confirmed somatic variant 25344691 NS NS 80.91 ENSP00000395243.3:p.Arg635Gln ENST00000454757.6:c.1904G>A 7:g.55173102G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812122 2812122 2668571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010004-T01-IM5 2725823 2584644 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1063625 1063625 979670 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1595811 1595811 1516608 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51837721 COSM133589 133233465 c.2479G>A p.E827K Substitution - Missense hom 38 7:55191863-55191863 + - PATHOGENIC .98912 Confirmed somatic variant 16551849 surgery-fixed NS 41 ENSP00000415559.1:p.Glu827Lys ENST00000455089.5:c.2479G>A 7:g.55191863G>A EGFR ENST00000275493.6 3633 3236 1458677 1458677 1382652 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876036 2876036 2730551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 133203473 c.2117C>T p.T706I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Confirmed somatic variant 29506987 NS recurrent 62 ENSP00000415559.1:p.Thr706Ile ENST00000455089.5:c.2117C>T 7:g.55174789C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876036 2876036 2730551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 62 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982874 982874 898593 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2115528 2115528 1989772 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982784 982784 898503 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982784 982784 898503 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2011-2283:2012-316-T 2297701 2163302 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51817336 COSM4604310 133259735 c.1241G>C p.G414A Substitution - Missense hom 38 7:55160216-55160216 + - PATHOGENIC .99469 Confirmed somatic variant 25056374 surgery-fixed NS ENSP00000415559.1:p.Gly414Ala ENST00000455089.5:c.1241G>C 7:g.55160216G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2011-2283:2012-316-T 2297701 2163302 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51817351 COSM3881830 133223235 c.2957G>A p.R986Q Substitution - Missense hom 38 7:55201333-55201333 + - PATHOGENIC .98371 Confirmed somatic variant 25056374 surgery-fixed NS ENSP00000415559.1:p.Arg986Gln ENST00000455089.5:c.2957G>A 7:g.55201333G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000390-T01-IM3 2715182 2574003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-AZ-6599-01 1651173 1565960 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51797242 COSM1451615 99411020 c.2677C>T p.H893Y Substitution - Missense 38 7:55192817-55192817 + - PATHOGENIC .94682 Confirmed somatic variant 376 NS NS 72 ENSP00000275493.2:p.His893Tyr ENST00000275493.6:c.2677C>T 7:g.55192817C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-S9-A7R2-01 2263272 2130256 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 69 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 P-0004104-T01-IM5 2720505 2579326 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51846321 COSM6933335 99448223 c.1908T>G p.C636W Substitution - Missense het 38 7:55171202-55171202 + - .63273 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Cys636Trp ENST00000275493.6:c.1908T>G 7:g.55171202T>G EGFR ENST00000275493.6 3633 3236 2675012 2675012 2534307 thymus thyroid NS NS other spindle_epithelial_tumour_with_thymus_like_differentiation NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 29115061 surgery-fixed NS 40 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 TCGA-FS-A1ZK-06 2121762 1995998 skin NS NS NS malignant_melanoma NS NS NS y COSV51790737 COSM3639739 99437856 c.1621C>T p.L541F Substitution - Missense 38 7:55161621-55161621 + - NEUTRAL .0484 Confirmed somatic variant 540 NS NS 68 ENSP00000275493.2:p.Leu541Phe ENST00000275493.6:c.1621C>T 7:g.55161621C>T EGFR ENST00000275493.6 3633 3236 1194727 1194727 1106622 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007681-T01-IM5 2723954 2582775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CRC403 2730857 2589626 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105863818 COSM10064830 132560445 c.926C>T p.T309M Substitution - Missense 38 7:55156587-55156587 + - PATHOGENIC .97048 Confirmed somatic variant 26416732 xenograft metastasis ENSP00000395243.3:p.Thr309Met ENST00000454757.6:c.926C>T 7:g.55156587C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007582-T01-IM5 2723867 2582688 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194734 1194734 1106629 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211132 1211132 1123000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 69 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489263 1489263 1412421 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 86566 1520669 1443044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20668451 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1451152 1451152 1375295 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2857119 2857119 2712419 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV105110043 COSM9533927 133247133 c.175G>A p.E59K Substitution - Missense 38 7:55142372-55142372 + - PATHOGENIC .93877 Confirmed somatic variant 25096233 surgery - NOS NS ENSP00000415559.1:p.Glu59Lys ENST00000455089.5:c.175G>A 7:g.55142372G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T3527 2658694 2518853 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51798634 COSM4680402 132560335 c.3304G>A p.V1102I Substitution - Missense 38 7:55205423-55205423 + - NEUTRAL .18974 Confirmed somatic variant 27149842 NS NS 73.91 ENSP00000395243.3:p.Val1102Ile ENST00000454757.6:c.3304G>A 7:g.55205423G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001250 1001250 918473 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-19-2621-01 2178211 2046509 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51863722 COSM13560 132565532 c.1736G>T p.C579F Substitution - Missense 38 7:55165428-55165428 + - PATHOGENIC .99905 Confirmed somatic variant 329 NS NS 83 ENSP00000395243.3:p.Cys579Phe ENST00000454757.6:c.1736G>T 7:g.55165428G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-0657-01 2178279 2046577 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 329 NS NS 69 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-0657-01 2178279 2046577 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99286086 COSM7481785 132584445 c.133G>A p.E45K Substitution - Missense 38 7:55142330-55142330 + - PATHOGENIC .99554 Confirmed somatic variant 329 NS NS 69 ENSP00000395243.3:p.Glu45Lys ENST00000454757.6:c.133G>A 7:g.55142330G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 897282 897282 814905 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15118073 surgery fresh/frozen primary 45 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-0657-01 2178279 2046577 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772147 COSM375343 132564558 c.1799C>G p.S600C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Confirmed somatic variant 329 NS NS 69 ENSP00000395243.3:p.Ser600Cys ENST00000454757.6:c.1799C>G 7:g.55172997C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-0657-01 2178279 2046577 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99286091 COSM7481779 132584469 c.2973C>G p.S991R Substitution - Missense 38 7:55201349-55201349 + - PATHOGENIC .75459 Confirmed somatic variant 329 NS NS 69 ENSP00000395243.3:p.Ser991Arg ENST00000454757.6:c.2973C>G 7:g.55201349C>G EGFR ENST00000275493.6 3633 3236 945810 945810 862336 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 16144918 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-81-5910-01 2120398 1994634 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 133208833 c.619C>T p.R207C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 NS NS 64 ENSP00000415559.1:p.Arg207Cys ENST00000455089.5:c.619C>T 7:g.55154017C>T EGFR ENST00000275493.6 3633 3236 1471552 1471552 1395291 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DU-6410-01 2194391 2062669 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 56 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811943 2811943 2668490 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 55 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 WGC003566 2785058 2645174 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS y COSV51806564 COSM6920868 99383183 c.2006G>A p.R669Q Substitution - Missense 38 7:55173069-55173069 + - PATHOGENIC .99699 Confirmed somatic variant 25526346 surgery fresh/frozen primary 54 ENSP00000275493.2:p.Arg669Gln ENST00000275493.6:c.2006G>A 7:g.55173069G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152797 2152797 2021807 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1502208 1502208 1425087 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51790305 COSM13194 132551901 c.2405C>T p.T802I Substitution - Missense het 38 7:55191789-55191789 + - PATHOGENIC .95119 Confirmed somatic variant 21457545 surgery-fixed NS ENSP00000395243.3:p.Thr802Ile ENST00000454757.6:c.2405C>T 7:g.55191789C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PL9 2492972 2355586 breast NS NS NS carcinoma lobular_carcinoma pleomorphic NS y COSV105110769 COSM9569122 132600999 c.212A>C p.Q71P Substitution - Missense 38 7:55142409-55142409 + - PATHOGENIC .94041 Confirmed somatic variant 26907767 surgery fresh/frozen primary ENSP00000395243.3:p.Gln71Pro ENST00000454757.6:c.212A>C 7:g.55142409A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-K4-A3WU-01 2193299 2061577 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51793030 COSM133566 132578206 c.2372G>A p.R791H Substitution - Missense 38 7:55191756-55191756 + - PATHOGENIC .98912 Confirmed somatic variant 413 NS NS 87 ENSP00000395243.3:p.Arg791His ENST00000454757.6:c.2372G>A 7:g.55191756G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489253 1489253 1412411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-QB-AA9O-06 2339489 2204472 skin NS NS NS malignant_melanoma NS NS NS y COSV51785510 COSM6957413 133202339 c.967G>A p.D323N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 540 NS NS 73 ENSP00000415559.1:p.Asp323Asn ENST00000455089.5:c.967G>A 7:g.55156628G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1048202 1048202 964430 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17238183 surgery fresh/frozen NS 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876625 2876625 2731140 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920114 920114 837193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773712 COSM13433 132558066 c.2183A>G p.H728R Substitution - Missense hom 38 7:55181327-55181327 + - PATHOGENIC .98391 Confirmed somatic variant 15623594 surgery-fixed NS 66 ENSP00000395243.3:p.His728Arg ENST00000454757.6:c.2183A>G 7:g.55181327A>G EGFR ENST00000275493.6 3633 3236 S02249_1 2480880 2343625 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV51799414 COSM5680213 99398091 c.3499C>G p.L1167V Substitution - Missense 38 7:55205483-55205483 + - PATHOGENIC .88717 Confirmed somatic variant 26168399 surgery fresh/frozen primary 74 ENSP00000275493.2:p.Leu1167Val ENST00000275493.6:c.3499C>G 7:g.55205483C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 W016-S1 2732510 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51785510 COSM6957413 132547201 c.967G>A p.D323N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000395243.3:p.Asp323Asn ENST00000454757.6:c.967G>A 7:g.55156628G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 W016-S1 2732510 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 TCGA-26-1439 2108054 1985915 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 2591431 2591431 2452391 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1206770 1206770 1118648 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CHG-13-09089T 2634309 2494705 liver NS NS NS other neoplasm NS NS y COSV51811749 COSM6242 132561254 c.2170G>T p.V724L Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .9836 Confirmed somatic variant 660 NS primary 67 ENSP00000395243.3:p.Val724Leu ENST00000454757.6:c.2170G>T 7:g.55181314G>T EGFR ENST00000275493.6 3633 3236 1451154 1451154 1375297 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982873 982873 898592 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1004980 1004980 922192 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1044281 1044281 960622 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 65 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1113111 1113111 1026612 thymus NS NS NS thymoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18448188 surgery-fixed NS 65 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 658 898392 816004 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2492702 2492702 2355317 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 99401924 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000275493.2:p.His47Tyr ENST00000275493.6:c.139C>T 7:g.55142336C>T EGFR ENST00000275493.6 3633 3236 TCGA-GN-A8LN-01 2339478 2204461 skin NS NS NS malignant_melanoma NS NS NS y COSV99295987 COSM7976353 99408931 c.815C>T p.P272L Substitution - Missense 38 7:55154078-55154078 + - PATHOGENIC .98876 Confirmed somatic variant 540 NS primary 68 ENSP00000275493.2:p.Pro272Leu ENST00000275493.6:c.815C>T 7:g.55154078C>T EGFR ENST00000275493.6 3633 3236 TCGA-GN-A8LN-01 2339478 2204461 skin NS NS NS malignant_melanoma NS NS NS y COSV99295991 COSM7976081 99408951 c.1135G>A p.D379N Substitution - Missense 38 7:55156760-55156760 + - PATHOGENIC .99676 Confirmed somatic variant 540 NS primary 68 ENSP00000275493.2:p.Asp379Asn ENST00000275493.6:c.1135G>A 7:g.55156760G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 20-2 2746109 2604812 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51794834 COSM5575633 133214600 c.2738G>A p.R913H Substitution - Missense 38 7:55200340-55200340 + - PATHOGENIC .99504 Confirmed somatic variant 646 NS primary 59 ENSP00000415559.1:p.Arg913His ENST00000455089.5:c.2738G>A 7:g.55200340G>A EGFR ENST00000275493.6 3633 3236 PCA1897 2861532 2716771 prostate NS NS NS carcinoma NS NS NS n COSV51777202 COSM20896 99421874 c.2500G>A p.V834M Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .98912 Confirmed somatic variant 32268276 circulating tumour NS ENSP00000275493.2:p.Val834Met ENST00000275493.6:c.2500G>A 7:g.55191749G>A EGFR ENST00000275493.6 3633 3236 CLL107 1897543 1786227 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51791822 COSM1292529 99415038 c.3325G>A p.V1109I Substitution - Missense 38 7:55205309-55205309 + - .63125 Confirmed somatic variant 23415222 blood-bone marrow NS ENSP00000275493.2:p.Val1109Ile ENST00000275493.6:c.3325G>A 7:g.55205309G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2823203 2823203 2679056 lung left_lower_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29074208 surgery - NOS primary 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2823203 2823203 2679056 lung left_lower_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51766509 COSM5945664 133219858 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + - PATHOGENIC .98511 Confirmed somatic variant 29074208 surgery - NOS primary 75 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2255G>C 7:g.55181399G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458692 1458692 1382667 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004811 1004811 922023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16140420 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812068 2812068 2668544 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 pleural effusion NS 44 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0009346-T01-IM5 2725290 2584111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811985 2811985 2668504 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 57 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-06-0747-01 1337860 1248245 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 53 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001582-T01-IM3 2717588 2576409 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769747 COSM297803 133236604 c.772G>C p.D258H Substitution - Missense het 38 7:55155847-55155847 + - PATHOGENIC .99461 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Asp258His ENST00000455089.5:c.772G>C 7:g.55155847G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S001092 1027684 944660 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005007 1005007 922219 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2733978 2733978 2592705 soft_tissue fat NS NS liposarcoma NS NS NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 29731991 surgery-fixed recurrent ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2492721 2492721 2355336 skin NS NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 133212507 c.2890G>A p.D964N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000415559.1:p.Asp964Asn ENST00000455089.5:c.2890G>A 7:g.55201266G>A EGFR ENST00000275493.6 3633 3236 T341 2658331 2518490 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51784286 COSM6652281 99383082 c.116C>T p.T39M Substitution - Missense 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 27149842 NS NS 66.58 ENSP00000275493.2:p.Thr39Met ENST00000275493.6:c.116C>T 7:g.55142313C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982783 982783 898502 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51868328 COSM18422 132606311 c.2225A>G p.Q742R Substitution - Missense 38 7:55181369-55181369 + - PATHOGENIC .9793 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Gln742Arg ENST00000454757.6:c.2225A>G 7:g.55181369A>G EGFR ENST00000275493.6 3633 3236 P-0002309-T01-IM3 2718596 2577417 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982783 982783 898502 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LICA-CN-HCC048T 2634095 2494491 liver NS NS NS other neoplasm NS NS y COSV51841658 COSM5820522 99445939 c.2746G>A p.D916N Substitution - Missense 38 7:55198761-55198761 + - PATHOGENIC .9794 Confirmed somatic variant 660 NS primary 54 ENSP00000275493.2:p.Asp916Asn ENST00000275493.6:c.2746G>A 7:g.55198761G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 B42-S1 2732496 2591261 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV104576683 COSM9498592 133232734 c.823G>C p.E275Q Substitution - Missense 38 7:55155898-55155898 + - PATHOGENIC .98914 Confirmed somatic variant 29244145 surgery fresh/frozen primary 70.1 ENSP00000415559.1:p.Glu275Gln ENST00000455089.5:c.823G>C 7:g.55155898G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460113 1460113 1383990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51806104 COSM52932 132554560 c.2131A>T p.N711Y Substitution - Missense 38 7:55174803-55174803 + - PATHOGENIC .99468 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000395243.3:p.Asn711Tyr ENST00000454757.6:c.2131A>T 7:g.55174803A>T EGFR ENST00000275493.6 3633 3236 1140663 1140663 1053111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26138 178387145 c.? p.L692P Substitution - Missense + - Confirmed somatic variant 19238633 surgery-fixed primary 56 EGFR ENST00000275493.6 3633 3236 17228 1423804 1333832 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152775 2152775 2021785 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CHG-13-09089T 2634309 2494705 liver NS NS NS other neoplasm NS NS y COSV51858993 COSM6253894 132596105 c.2871G>T p.M957I Substitution - Missense 38 7:55201247-55201247 + - PATHOGENIC .94822 Confirmed somatic variant 660 NS primary 67 ENSP00000395243.3:p.Met957Ile ENST00000454757.6:c.2871G>T 7:g.55201247G>T EGFR ENST00000275493.6 3633 3236 W16T 2745047 2603750 thyroid NS NS NS carcinoma NS NS NS y COSV51794993 COSM6399094 99394153 c.5G>A p.R2Q Substitution - Missense 38 7:55019282-55019282 + - NEUTRAL .46409 Confirmed somatic variant 676 NS primary 40 ENSP00000275493.2:p.Arg2Gln ENST00000275493.6:c.5G>A 7:g.55019282G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DD282_Org 2749235 2607934 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51784286 COSM6652281 133211716 c.116C>T p.T39M Substitution - Missense het 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 29703791 organoid culture primary 81 ENSP00000415559.1:p.Thr39Met ENST00000455089.5:c.116C>T 7:g.55142313C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1063623 1063623 979668 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 85 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920026 920026 837105 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 56 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0002488-T01-IM3 2718760 2577581 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1460149 1460149 1384026 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002124-T01-IM3 2829436 2685251 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51806564 COSM6920868 132555861 c.1871G>A p.R624Q Substitution - Missense 38 7:55173069-55173069 + - PATHOGENIC .99699 Confirmed somatic variant 30205045 surgery-fixed metastasis 53 ENSP00000395243.3:p.Arg624Gln ENST00000454757.6:c.1871G>A 7:g.55173069G>A EGFR ENST00000275493.6 3633 3236 TCGA-CV-7250-01 2193784 2062062 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51827895 COSM3412174 99379092 c.685A>T p.S229C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 627 NS NS 64 ENSP00000275493.2:p.Ser229Cys ENST00000275493.6:c.685A>T 7:g.55152602A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914585 914585 832034 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 80 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982792 982792 898511 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A014-T-S21 2758133 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2812122 2812122 2668571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003116-T02-IM5 2719611 2578432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51809537 COSM6926377 132562562 c.2906A>T p.D969V Substitution - Missense het 38 7:55201282-55201282 + - PATHOGENIC .99519 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Asp969Val ENST00000454757.6:c.2906A>T 7:g.55201282A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003116-T02-IM5 2719611 2578432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1909609 1909609 1798129 oesophagus NS NS NS carcinoma carcinosarcoma NS NS n COSV51773932 COSM1272071 132568328 c.2233A>G p.T745A Substitution - Missense 38 7:55181377-55181377 + - PATHOGENIC .9793 Confirmed somatic variant 23546020 fixed - NOS NS ENSP00000395243.3:p.Thr745Ala ENST00000454757.6:c.2233A>G 7:g.55181377A>G EGFR ENST00000275493.6 3633 3236 P-0010004-T01-IM5 2725823 2584644 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010554-T01-IM5 2726255 2585076 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1063625 1063625 979670 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1595811 1595811 1516608 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51837721 COSM133589 99406895 c.2614G>A p.E872K Substitution - Missense hom 38 7:55191863-55191863 + - PATHOGENIC .98912 Confirmed somatic variant 16551849 surgery-fixed NS 41 ENSP00000275493.2:p.Glu872Lys ENST00000275493.6:c.2614G>A 7:g.55191863G>A EGFR ENST00000275493.6 3633 3236 2876036 2876036 2730551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 99375118 c.2252C>T p.T751I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Confirmed somatic variant 29506987 NS recurrent 62 ENSP00000275493.2:p.Thr751Ile ENST00000275493.6:c.2252C>T 7:g.55174789C>T EGFR ENST00000275493.6 3633 3236 2876036 2876036 2730551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 62 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EXTERN_MELA_20140524_012 2839317 2695083 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51776559 COSM4892884 132554171 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000395243.3:p.Pro100Ser ENST00000454757.6:c.298C>T 7:g.55143362C>T EGFR ENST00000275493.6 3633 3236 982874 982874 898593 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EXTERN_MELA_20140524_012 2839317 2695083 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 132554177 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000395243.3:p.Ser116Phe ENST00000454757.6:c.347C>T 7:g.55143411C>T EGFR ENST00000275493.6 3633 3236 2011-2283:2012-316-T 2297701 2163302 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51817336 COSM4604310 99436819 c.1376G>C p.G459A Substitution - Missense hom 38 7:55160216-55160216 + - PATHOGENIC .99469 Confirmed somatic variant 25056374 surgery-fixed NS ENSP00000275493.2:p.Gly459Ala ENST00000275493.6:c.1376G>C 7:g.55160216G>C EGFR ENST00000275493.6 3633 3236 2011-2283:2012-316-T 2297701 2163302 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51817351 COSM3881830 99397516 c.3092G>A p.R1031Q Substitution - Missense hom 38 7:55201333-55201333 + - PATHOGENIC .98371 Confirmed somatic variant 25056374 surgery-fixed NS ENSP00000275493.2:p.Arg1031Gln ENST00000275493.6:c.3092G>A 7:g.55201333G>A EGFR ENST00000275493.6 3633 3236 P-0000390-T01-IM3 2715182 2574003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008917-T01-IM5 2724934 2583755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008917-T01-IM5 2724934 2583755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-S9-A7R2-01 2263272 2130256 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 69 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 2591449 2591449 2452409 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1179548 1179548 1091510 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 52 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G HOOK3 ENST00000307602.8 2157 23576 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105885831 COSM10012951 105832105 c.2060G>A p.S687N Substitution - Missense 38 8:43018401-43018401 + - PATHOGENIC .94683 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000305699.3:p.Ser687Asn ENST00000307602.8:c.2060G>A 8:g.43018401G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1468099 1468099 1391945 peritoneum NS NS NS mesothelioma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1211132 1211132 1123000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 69 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920038 920038 837117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 15623594 surgery fresh/frozen NS 63 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 YUFARCI 2013606 1896238 skin NS NS NS malignant_melanoma NS NS NS y COSV51816429 COSM1698693 132561822 c.1675A>G p.N559D Substitution - Missense het 38 7:55165367-55165367 + - NEUTRAL .4812 Confirmed somatic variant 22842228 NS NS ENSP00000395243.3:p.Asn559Asp ENST00000454757.6:c.1675A>G 7:g.55165367A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SJHGG029_R 2307362 2172566 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 24705251 surgery - NOS recurrent 4 ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 86564 1520630 1443005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51774667 COSM53194 132555352 c.2062C>T p.P688S Substitution - Missense 38 7:55174734-55174734 + - PATHOGENIC .99806 Confirmed somatic variant 20668451 NS primary ENSP00000395243.3:p.Pro688Ser ENST00000454757.6:c.2062C>T 7:g.55174734C>T EGFR ENST00000275493.6 3633 3236 1489263 1489263 1412421 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 86566 1520669 1443044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20668451 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006363-T01-IM5 2722740 2581561 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 132550339 c.731C>A p.A244D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Ala244Asp ENST00000454757.6:c.731C>A 7:g.55154129C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006363-T01-IM5 2722740 2581561 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1790514 1790514 1693493 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51778758 COSM707337 133212920 c.2458G>A p.E820K Substitution - Missense 38 7:55191842-55191842 + - PATHOGENIC .97736 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000415559.1:p.Glu820Lys ENST00000455089.5:c.2458G>A 7:g.55191842G>A EGFR ENST00000275493.6 3633 3236 2857119 2857119 2712419 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV105110043 COSM9533927 99422654 c.175G>A p.E59K Substitution - Missense 38 7:55142372-55142372 + - PATHOGENIC .93877 Confirmed somatic variant 25096233 surgery - NOS NS ENSP00000275493.2:p.Glu59Lys ENST00000275493.6:c.175G>A 7:g.55142372G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152696 2152696 2021706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152696 2152696 2021706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152780 2152780 2021790 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 897282 897282 814905 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15118073 surgery fresh/frozen primary 45 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-QB-AA9O-06 2339489 2204472 skin NS NS NS malignant_melanoma NS NS NS y COSV51785510 COSM6957413 99373603 c.1102G>A p.D368N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 540 NS NS 73 ENSP00000275493.2:p.Asp368Asn ENST00000275493.6:c.1102G>A 7:g.55156628G>A EGFR ENST00000275493.6 3633 3236 TCGA-81-5910-01 2120398 1994634 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 99380629 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 NS NS 64 ENSP00000275493.2:p.Arg252Cys ENST00000275493.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-CD-A4MI-01 2198040 2066318 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51771322 COSM3881814 133218680 c.916A>G p.I306V Substitution - Missense 38 7:55156577-55156577 + - PATHOGENIC .89527 Confirmed somatic variant 541 NS NS 62 ENSP00000415559.1:p.Ile306Val ENST00000455089.5:c.916A>G 7:g.55156577A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002890-T01-IM3 2719115 2577936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004988 1004988 922200 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1451161 1451161 1375304 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T1196 2658782 2518941 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51797600 COSM5575629 133226884 c.391G>A p.G131R Substitution - Missense 38 7:55143455-55143455 + - PATHOGENIC .99768 Confirmed somatic variant 27149842 NS NS 70.83 ENSP00000415559.1:p.Gly131Arg ENST00000455089.5:c.391G>A 7:g.55143455G>A EGFR ENST00000275493.6 3633 3236 2811943 2811943 2668490 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 55 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1468637 1468637 1392388 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S0388 897614 815237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15118125 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-13-0717-01 1475078 1398777 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51824273 COSM116668 133274371 c.2381C>T p.A794V Substitution - Missense het 38 7:55191765-55191765 + - PATHOGENIC .97911 Confirmed somatic variant 21720365 331 NS primary 54 ENSP00000415559.1:p.Ala794Val ENST00000455089.5:c.2381C>T 7:g.55191765C>T NPAT ENST00000278612.8 4284 7896 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105845050 COSM10012936 100981944 c.1942G>A p.E648K Substitution - Missense 38 11:108173042-108173042 - - NEUTRAL .05115 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000278612.8:p.Glu648Lys ENST00000278612.8:c.1942G>A 11:g.108173042C>T EGFR ENST00000275493.6 3633 3236 2152797 2152797 2021807 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008346-T01-IM5 2787024 2644447 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51838649 COSM6962468 133243598 c.412A>G p.R138G Substitution - Missense hom 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000415559.1:p.Arg138Gly ENST00000455089.5:c.412A>G 7:g.55143476A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007771-T01-IM5 2724004 2582825 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51862622 COSM6959670 133202767 c.1187T>G p.V396G Substitution - Missense het 38 7:55160162-55160162 + - PATHOGENIC .9258 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Val396Gly ENST00000455089.5:c.1187T>G 7:g.55160162T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 ccRCC-90 1980826 1867072 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51815313 COSM1661639 133248320 c.538G>T p.G180C Substitution - Missense 38 7:55152590-55152590 + - PATHOGENIC .99717 Confirmed somatic variant 23797736 NS NS ENSP00000415559.1:p.Gly180Cys ENST00000455089.5:c.538G>T 7:g.55152590G>T EGFR ENST00000275493.6 3633 3236 1489253 1489253 1412411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003495-T01-IM5 2719974 2578795 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 132550443 c.2104_2105delinsCC p.L702P Substitution - Missense het 38 7:55174776-55174777 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu702Pro ENST00000454757.6:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-YG-AA3N-01 2339750 2204733 skin NS NS NS malignant_melanoma NS NS NS y COSV51794869 COSM4362780 132549800 c.439C>T p.P147S Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 540 NS primary 67 ENSP00000395243.3:p.Pro147Ser ENST00000454757.6:c.439C>T 7:g.55151308C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_S50 1863766 1754657 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2492721 2492721 2355336 skin NS NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 99383908 c.3025G>A p.D1009N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000275493.2:p.Asp1009Asn ENST00000275493.6:c.3025G>A 7:g.55201266G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007508-T01-IM5 2723793 2582614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 20-2 2746109 2604812 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51794834 COSM5575633 99386191 c.2873G>A p.R958H Substitution - Missense 38 7:55200340-55200340 + - PATHOGENIC .99504 Confirmed somatic variant 646 NS primary 59 ENSP00000275493.2:p.Arg958His ENST00000275493.6:c.2873G>A 7:g.55200340G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T3262 2296207 2161810 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51822879 COSM4680399 133211230 c.1904G>A p.R635Q Substitution - Missense 38 7:55173102-55173102 + - PATHOGENIC .99814 Confirmed somatic variant 25344691 NS NS 80.91 ENSP00000415559.1:p.Arg635Gln ENST00000455089.5:c.1904G>A 7:g.55173102G>A EGFR ENST00000275493.6 3633 3236 2823203 2823203 2679056 lung left_lower_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51766509 COSM5945664 99392475 c.2390G>C p.C797S Substitution - Missense 38 7:55181399-55181399 + - PATHOGENIC .98511 Confirmed somatic variant 29074208 surgery - NOS primary 75 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2390G>C 7:g.55181399G>C EGFR ENST00000275493.6 3633 3236 2823203 2823203 2679056 lung left_lower_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29074208 surgery - NOS primary 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876658 2876658 2731173 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 80 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458692 1458692 1382667 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 4577 915975 833374 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0001582-T01-IM3 2717588 2576409 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769747 COSM297803 99409471 c.907G>C p.D303H Substitution - Missense het 38 7:55155847-55155847 + - PATHOGENIC .99461 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Asp303His ENST00000275493.6:c.907G>C 7:g.55155847G>C EGFR ENST00000275493.6 3633 3236 S001092 1027684 944660 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 1005007 1005007 922219 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2733978 2733978 2592705 soft_tissue fat NS NS liposarcoma NS NS NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 29731991 surgery-fixed recurrent ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811944 2811944 2668490 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 55 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002022-T01-IM3 2718329 2577150 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 132553689 c.619C>T p.R207C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg207Cys ENST00000454757.6:c.619C>T 7:g.55154017C>T EGFR ENST00000275493.6 3633 3236 B42-S1 2732496 2591261 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV104576683 COSM9498592 99406410 c.958G>C p.E320Q Substitution - Missense 38 7:55155898-55155898 + - PATHOGENIC .98914 Confirmed somatic variant 29244145 surgery fresh/frozen primary 70.1 ENSP00000275493.2:p.Glu320Gln ENST00000275493.6:c.958G>C 7:g.55155898G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982784 982784 898503 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982784 982784 898503 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2696712 2696712 2555616 oesophagus NS NS NS other metaplasia epidermoid NS n COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28731047 surgery-fixed primary 65 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594191 1594191 1515165 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51799836 COSM133563 132561054 c.2159T>G p.V720G Substitution - Missense het 38 7:55181303-55181303 + - PATHOGENIC .97973 Confirmed somatic variant 19726454 surgery fresh/frozen primary 58 ENSP00000395243.3:p.Val720Gly ENST00000454757.6:c.2159T>G 7:g.55181303T>G EGFR ENST00000275493.6 3633 3236 P-0003529-T01-IM5 2720010 2578831 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51803297 COSM6285115 99444146 c.3323C>T p.P1108L Substitution - Missense het 38 7:55205307-55205307 + - PATHOGENIC .91978 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Pro1108Leu ENST00000275493.6:c.3323C>T 7:g.55205307C>T EGFR ENST00000275493.6 3633 3236 2152775 2152775 2021785 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T2565 2658399 2518558 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51771628 COSM1205054 132552472 c.1876C>T p.R626C Substitution - Missense 38 7:55173074-55173074 + - PATHOGENIC .99716 Confirmed somatic variant 27149842 NS NS 66.25 ENSP00000395243.3:p.Arg626Cys ENST00000454757.6:c.1876C>T 7:g.55173074C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811938 2811938 2668488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour metastasis 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1063623 1063623 979668 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 85 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2901984 2901984 2756227 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2901984 2901984 2756227 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Leu861Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007681-T01-IM5 2723954 2582775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152766 2152766 2021776 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 DD282_Org 2749235 2607934 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51784286 COSM6652281 99383082 c.116C>T p.T39M Substitution - Missense het 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 29703791 organoid culture primary 81 ENSP00000275493.2:p.Thr39Met ENST00000275493.6:c.116C>T 7:g.55142313C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2012-695:2012-1303-T 2297791 2163392 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51840606 COSM4605183 132565746 c.3337G>C p.A1113P Substitution - Missense hom 38 7:55205456-55205456 + - PATHOGENIC .80039 Confirmed somatic variant 25056374 surgery-fixed NS ENSP00000395243.3:p.Ala1113Pro ENST00000454757.6:c.3337G>C 7:g.55205456G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811957 2811957 2668495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed metastasis 79 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CRC403 2730857 2589626 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105863818 COSM10064830 133216505 c.926C>T p.T309M Substitution - Missense 38 7:55156587-55156587 + - PATHOGENIC .97048 Confirmed somatic variant 26416732 xenograft metastasis ENSP00000415559.1:p.Thr309Met ENST00000455089.5:c.926C>T 7:g.55156587C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007582-T01-IM5 2723867 2582688 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206721 1206721 1118599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194734 1194734 1106629 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PT36 2521293 2383636 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV51784241 COSM5915646 132582458 c.1055C>T p.T352I Substitution - Missense 38 7:55156815-55156815 + - PATHOGENIC .99038 Confirmed somatic variant 25759019 surgery fresh/frozen NS ENSP00000395243.3:p.Thr352Ile ENST00000454757.6:c.1055C>T 7:g.55156815C>T EGFR ENST00000275493.6 3633 3236 P-0010554-T01-IM5 2726255 2585076 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001250 1001250 918473 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-19-2621-01 2178211 2046509 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51863722 COSM13560 133221958 c.1736G>T p.C579F Substitution - Missense 38 7:55165428-55165428 + - PATHOGENIC .99905 Confirmed somatic variant 329 NS NS 83 ENSP00000415559.1:p.Cys579Phe ENST00000455089.5:c.1736G>T 7:g.55165428G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152769 2152769 2021779 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-0657-01 2178279 2046577 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99286091 COSM7481779 133245658 c.2973C>G p.S991R Substitution - Missense 38 7:55201349-55201349 + - PATHOGENIC .75459 Confirmed somatic variant 329 NS NS 69 ENSP00000415559.1:p.Ser991Arg ENST00000455089.5:c.2973C>G 7:g.55201349C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-0657-01 2178279 2046577 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99286086 COSM7481785 133245628 c.133G>A p.E45K Substitution - Missense 38 7:55142330-55142330 + - PATHOGENIC .99554 Confirmed somatic variant 329 NS NS 69 ENSP00000415559.1:p.Glu45Lys ENST00000455089.5:c.133G>A 7:g.55142330G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-0657-01 2178279 2046577 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772147 COSM375343 133220930 c.1799C>G p.S600C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Confirmed somatic variant 329 NS NS 69 ENSP00000415559.1:p.Ser600Cys ENST00000455089.5:c.1799C>G 7:g.55172997C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-0657-01 2178279 2046577 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 329 NS NS 69 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 16 2630307 2490691 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51780760 COSM6196858 132571977 c.341A>G p.E114G Substitution - Missense 38 7:55143405-55143405 + - PATHOGENIC .99844 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000395243.3:p.Glu114Gly ENST00000454757.6:c.341A>G 7:g.55143405A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 16 2630307 2490691 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51780766 COSM219795 132546924 c.2456C>T p.A819V Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .93098 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000395243.3:p.Ala819Val ENST00000454757.6:c.2456C>T 7:g.55191840C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DU-6410-01 2194391 2062669 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 56 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-0691-01 2178100 2046398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774829 COSM1451549 132549970 c.632A>G p.D211G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 329 NS NS 63 ENSP00000395243.3:p.Asp211Gly ENST00000454757.6:c.632A>G 7:g.55154030A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006368-T01-IM5 2722745 2581566 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51843325 COSM6950386 132579212 c.967G>T p.D323Y Substitution - Missense het 38 7:55156628-55156628 + - PATHOGENIC .97349 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Asp323Tyr ENST00000454757.6:c.967G>T 7:g.55156628G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1502208 1502208 1425087 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51790305 COSM13194 133206846 c.2405C>T p.T802I Substitution - Missense het 38 7:55191789-55191789 + - PATHOGENIC .95119 Confirmed somatic variant 21457545 surgery-fixed NS ENSP00000415559.1:p.Thr802Ile ENST00000455089.5:c.2405C>T 7:g.55191789C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PL9 2492972 2355586 breast NS NS NS carcinoma lobular_carcinoma pleomorphic NS y COSV105110769 COSM9569122 133265156 c.212A>C p.Q71P Substitution - Missense 38 7:55142409-55142409 + - PATHOGENIC .94041 Confirmed somatic variant 26907767 surgery fresh/frozen primary ENSP00000415559.1:p.Gln71Pro ENST00000455089.5:c.212A>C 7:g.55142409A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-K4-A3WU-01 2193299 2061577 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51793030 COSM133566 133238435 c.2372G>A p.R791H Substitution - Missense 38 7:55191756-55191756 + - PATHOGENIC .98912 Confirmed somatic variant 413 NS NS 87 ENSP00000415559.1:p.Arg791His ENST00000455089.5:c.2372G>A 7:g.55191756G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1048202 1048202 964430 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17238183 surgery fresh/frozen NS 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876625 2876625 2731140 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1468099 1468099 1391945 peritoneum NS NS NS mesothelioma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920114 920114 837193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773712 COSM13433 133214162 c.2183A>G p.H728R Substitution - Missense hom 38 7:55181327-55181327 + - PATHOGENIC .98391 Confirmed somatic variant 15623594 surgery-fixed NS 66 ENSP00000415559.1:p.His728Arg ENST00000455089.5:c.2183A>G 7:g.55181327A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001097-T02-IM5 2719393 2578214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 920038 920038 837117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 15623594 surgery fresh/frozen NS 63 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 W016-S1 2732510 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 SJHGG029_R 2307362 2172566 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 24705251 surgery - NOS recurrent 4 ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 W016-S1 2732510 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51785510 COSM6957413 133202339 c.967G>A p.D323N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000415559.1:p.Asp323Asn ENST00000455089.5:c.967G>A 7:g.55156628G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982873 982873 898592 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001357-T02-IM5 2719416 2578237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1044281 1044281 960622 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 65 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1790514 1790514 1693493 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51778758 COSM707337 99384356 c.2593G>A p.E865K Substitution - Missense 38 7:55191842-55191842 + - PATHOGENIC .97736 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000275493.2:p.Glu865Lys ENST00000275493.6:c.2593G>A 7:g.55191842G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CHG-13-09089T 2634309 2494705 liver NS NS NS other neoplasm NS NS y COSV51811749 COSM6242 133217384 c.2170G>T p.V724L Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .9836 Confirmed somatic variant 660 NS primary 67 ENSP00000415559.1:p.Val724Leu ENST00000455089.5:c.2170G>T 7:g.55181314G>T EGFR ENST00000275493.6 3633 3236 1091718 1091718 1006540 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26144 178389266 c.? p.G874S Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS ENSP00000275493.2:p.Gly874Ser EGFR ENST00000275493.6 3633 3236 P-0002890-T01-IM3 2719115 2577936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-CD-A4MI-01 2198040 2066318 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51771322 COSM3881814 99391026 c.1051A>G p.I351V Substitution - Missense 38 7:55156577-55156577 + - PATHOGENIC .89527 Confirmed somatic variant 541 NS NS 62 ENSP00000275493.2:p.Ile351Val ENST00000275493.6:c.1051A>G 7:g.55156577A>G EGFR ENST00000275493.6 3633 3236 1004988 1004988 922200 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 T1196 2658782 2518941 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51797600 COSM5575629 99401472 c.391G>A p.G131R Substitution - Missense 38 7:55143455-55143455 + - PATHOGENIC .99768 Confirmed somatic variant 27149842 NS NS 70.83 ENSP00000275493.2:p.Gly131Arg ENST00000275493.6:c.391G>A 7:g.55143455G>A EGFR ENST00000275493.6 3633 3236 2150419 2150419 2019488 lung NS NS NS other dysplasia-carcinoma_in_situ NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 58 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004811 1004811 922023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16140420 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2150419 2150419 2019488 lung NS NS NS other dysplasia-carcinoma_in_situ NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 S0388 897614 815237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15118125 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812068 2812068 2668544 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 pleural effusion NS 44 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-13-0717-01 1475078 1398777 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51824273 COSM116668 99451082 c.2516C>T p.A839V Substitution - Missense het 38 7:55191765-55191765 + - PATHOGENIC .97911 Confirmed somatic variant 21720365 331 NS primary 54 ENSP00000275493.2:p.Ala839Val ENST00000275493.6:c.2516C>T 7:g.55191765C>T EGFR ENST00000275493.6 3633 3236 P-0008346-T01-IM5 2787024 2644447 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51838649 COSM6962468 99418377 c.412A>G p.R138G Substitution - Missense hom 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000275493.2:p.Arg138Gly ENST00000275493.6:c.412A>G 7:g.55143476A>G EGFR ENST00000275493.6 3633 3236 P-0007771-T01-IM5 2724004 2582825 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51862622 COSM6959670 99374133 c.1322T>G p.V441G Substitution - Missense het 38 7:55160162-55160162 + - PATHOGENIC .9258 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Val441Gly ENST00000275493.6:c.1322T>G 7:g.55160162T>G EGFR ENST00000275493.6 3633 3236 ccRCC-90 1980826 1867072 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51815313 COSM1661639 99423990 c.673G>T p.G225C Substitution - Missense 38 7:55152590-55152590 + - PATHOGENIC .99717 Confirmed somatic variant 23797736 NS NS ENSP00000275493.2:p.Gly225Cys ENST00000275493.6:c.673G>T 7:g.55152590G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811985 2811985 2668504 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 57 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876627 2876627 2731142 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 34 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 LC_S50 1863766 1754657 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982783 982783 898502 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982783 982783 898502 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51868328 COSM18422 133270937 c.2225A>G p.Q742R Substitution - Missense 38 7:55181369-55181369 + - PATHOGENIC .9793 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Gln742Arg ENST00000455089.5:c.2225A>G 7:g.55181369A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471538 1471538 1395277 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460097 1460097 1383974 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920027 920027 837106 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-55-A48Z-01 2194757 2063035 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 417 NS NS 60 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1505373 1505373 1428248 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BB-8596-01 2193542 2061820 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99289667 COSM8311578 132583317 c.1372G>A p.G458S Substitution - Missense 38 7:55161507-55161507 + - NEUTRAL .07845 Confirmed somatic variant 627 NS NS 69 ENSP00000395243.3:p.Gly458Ser ENST00000454757.6:c.1372G>A 7:g.55161507G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD36140a 2894853 2749341 skin extremity NS NS malignant_melanoma nodular NS NS y COSV105110902 COSM9873684 132583138 c.2171T>G p.V724G Substitution - Missense 38 7:55181315-55181315 + - PATHOGENIC .97973 Confirmed somatic variant 33024263 surgery-fixed metastasis 50 ENSP00000395243.3:p.Val724Gly ENST00000454757.6:c.2171T>G 7:g.55181315T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0155 2107953 1985814 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 132551380 c.775C>T p.H259Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.His259Tyr ENST00000454757.6:c.775C>T 7:g.55155850C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002105-T01-IM3 2718403 2577224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51844520 COSM6920741 132571526 c.504C>G p.I168M Substitution - Missense het 38 7:55152556-55152556 + - PATHOGENIC .89498 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ile168Met ENST00000454757.6:c.504C>G 7:g.55152556C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460113 1460113 1383990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51806104 COSM52932 133209943 c.2131A>T p.N711Y Substitution - Missense 38 7:55174803-55174803 + - PATHOGENIC .99468 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000415559.1:p.Asn711Tyr ENST00000455089.5:c.2131A>T 7:g.55174803A>T EGFR ENST00000275493.6 3633 3236 2876658 2876658 2731173 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 80 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000378-T01-IM3 2715158 2573979 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849115 COSM6910123 132567538 c.580G>T p.G194C Substitution - Missense het 38 7:55152632-55152632 + - PATHOGENIC .99578 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly194Cys ENST00000454757.6:c.580G>T 7:g.55152632G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000378-T01-IM3 2715158 2573979 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 132564457 c.1658G>C p.G553A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly553Ala ENST00000454757.6:c.1658G>C 7:g.55165350G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-X6-A7WB-01 2270285 2137053 soft_tissue NS NS NS sarcoma NS NS NS y COSV99286478 COSM8460648 132586775 c.3411G>T p.K1137N Substitution - Missense 38 7:55205530-55205530 + - PATHOGENIC .81374 Confirmed somatic variant 635 NS NS ENSP00000395243.3:p.Lys1137Asn ENST00000454757.6:c.3411G>T 7:g.55205530G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001613-T02-IM5 2719442 2578263 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 T3262 2296207 2161810 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51822879 COSM4680399 99382634 c.2039G>A p.R680Q Substitution - Missense 38 7:55173102-55173102 + - PATHOGENIC .99814 Confirmed somatic variant 25344691 NS NS 80.91 ENSP00000275493.2:p.Arg680Gln ENST00000275493.6:c.2039G>A 7:g.55173102G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CHG-13-09089T 2634309 2494705 liver NS NS NS other neoplasm NS NS y COSV51858993 COSM6253894 133259409 c.2871G>T p.M957I Substitution - Missense 38 7:55201247-55201247 + - PATHOGENIC .94822 Confirmed somatic variant 660 NS primary 67 ENSP00000415559.1:p.Met957Ile ENST00000455089.5:c.2871G>T 7:g.55201247G>T EGFR ENST00000275493.6 3633 3236 483-82 2605263 2466154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Confirmed somatic variant 25376516 surgery - NOS NS 77 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 982784 982784 898503 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982784 982784 898503 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002124-T01-IM3 2829436 2685251 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51806564 COSM6920868 133211798 c.1871G>A p.R624Q Substitution - Missense 38 7:55173069-55173069 + - PATHOGENIC .99699 Confirmed somatic variant 30205045 surgery-fixed metastasis 53 ENSP00000415559.1:p.Arg624Gln ENST00000455089.5:c.1871G>A 7:g.55173069G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914585 914585 832034 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 80 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A014-T-S21 2758133 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003116-T02-IM5 2719611 2578432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51809537 COSM6926377 133218861 c.2906A>T p.D969V Substitution - Missense het 38 7:55201282-55201282 + - PATHOGENIC .99519 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Asp969Val ENST00000455089.5:c.2906A>T 7:g.55201282A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003116-T02-IM5 2719611 2578432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1468562 1468562 1392313 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 21030498 surgery - NOS metastasis ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1909609 1909609 1798129 oesophagus NS NS NS carcinoma carcinosarcoma NS NS n COSV51773932 COSM1272071 133225284 c.2233A>G p.T745A Substitution - Missense 38 7:55181377-55181377 + - PATHOGENIC .9793 Confirmed somatic variant 23546020 fixed - NOS NS ENSP00000415559.1:p.Thr745Ala ENST00000455089.5:c.2233A>G 7:g.55181377A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 WG05M 2653266 2513393 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS metastasis 58.29 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982792 982792 898511 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000774-T01-IM3 2715962 2574783 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 C086 2465276 2328109 NS NS NS NS malignant_melanoma NS NS NS y COSV51846033 COSM5530399 132568942 c.2621C>T p.P874L Substitution - Missense 38 7:55198771-55198771 + - PATHOGENIC .97363 Confirmed somatic variant 23890154 cell-line metastasis ENSP00000395243.3:p.Pro874Leu ENST00000454757.6:c.2621C>T 7:g.55198771C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 C086 2465276 2328109 NS NS NS NS malignant_melanoma NS NS NS y COSV51845994 COSM5530405 132547619 c.1498G>A p.E500K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 23890154 cell-line metastasis ENSP00000395243.3:p.Glu500Lys ENST00000454757.6:c.1498G>A 7:g.55163734G>A EGFR ENST00000275493.6 3633 3236 P-0007681-T01-IM5 2723954 2582775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 CRC403 2730857 2589626 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105863818 COSM10064830 99388524 c.1061C>T p.T354M Substitution - Missense 38 7:55156587-55156587 + - PATHOGENIC .97048 Confirmed somatic variant 26416732 xenograft metastasis ENSP00000275493.2:p.Thr354Met ENST00000275493.6:c.1061C>T 7:g.55156587C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EXTERN_MELA_20140524_012 2839317 2695083 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51776559 COSM4892884 133209480 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000415559.1:p.Pro100Ser ENST00000455089.5:c.298C>T 7:g.55143362C>T EGFR ENST00000275493.6 3633 3236 P-0007582-T01-IM5 2723867 2582688 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2730925 2730925 2589694 skin acral NS NS malignant_melanoma acral_lentiginous NS NS n COSM7002291 178381254 c.? p.L704F Substitution - Missense + - Confirmed somatic variant 28870692 surgery - NOS NS 80 EGFR ENST00000275493.6 3633 3236 1194734 1194734 1106629 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EXTERN_MELA_20140524_012 2839317 2695083 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 133209492 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000415559.1:p.Ser116Phe ENST00000455089.5:c.347C>T 7:g.55143411C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008917-T01-IM5 2724934 2583755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008917-T01-IM5 2724934 2583755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1001250 1001250 918473 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 T3527 2658694 2518853 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51798634 COSM4680402 99388377 c.3439G>A p.V1147I Substitution - Missense 38 7:55205423-55205423 + - NEUTRAL .18974 Confirmed somatic variant 27149842 NS NS 73.91 ENSP00000275493.2:p.Val1147Ile ENST00000275493.6:c.3439G>A 7:g.55205423G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1179548 1179548 1091510 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 52 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-19-2621-01 2178211 2046509 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51863722 COSM13560 99395587 c.1871G>T p.C624F Substitution - Missense 38 7:55165428-55165428 + - PATHOGENIC .99905 Confirmed somatic variant 329 NS NS 83 ENSP00000275493.2:p.Cys624Phe ENST00000275493.6:c.1871G>T 7:g.55165428G>T EGFR ENST00000275493.6 3633 3236 TCGA-12-0657-01 2178279 2046577 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772147 COSM375343 99393933 c.1934C>G p.S645C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Confirmed somatic variant 329 NS NS 69 ENSP00000275493.2:p.Ser645Cys ENST00000275493.6:c.1934C>G 7:g.55172997C>G EGFR ENST00000275493.6 3633 3236 TCGA-12-0657-01 2178279 2046577 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 329 NS NS 69 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 TCGA-12-0657-01 2178279 2046577 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99286086 COSM7481785 99420885 c.133G>A p.E45K Substitution - Missense 38 7:55142330-55142330 + - PATHOGENIC .99554 Confirmed somatic variant 329 NS NS 69 ENSP00000275493.2:p.Glu45Lys ENST00000275493.6:c.133G>A 7:g.55142330G>A EGFR ENST00000275493.6 3633 3236 TCGA-12-0657-01 2178279 2046577 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99286091 COSM7481779 99420922 c.3108C>G p.S1036R Substitution - Missense 38 7:55201349-55201349 + - PATHOGENIC .75459 Confirmed somatic variant 329 NS NS 69 ENSP00000275493.2:p.Ser1036Arg ENST00000275493.6:c.3108C>G 7:g.55201349C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003967-T01-IM5 2720417 2579238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008343-T01-IM5 2724471 2583292 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS n COSV51790148 COSM22555 132554437 c.1895G>A p.R632H Substitution - Missense het 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg632His ENST00000454757.6:c.1895G>A 7:g.55173093G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2014_Lung_sq_14_T 2744885 2603588 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 58 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-B7-A5TI-01 2457338 2320175 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99290867 COSM8197349 132575572 c.2623G>T p.A875S Substitution - Missense 38 7:55198773-55198773 + - PATHOGENIC .98826 Confirmed somatic variant 541 NS primary 52 ENSP00000395243.3:p.Ala875Ser ENST00000454757.6:c.2623G>T 7:g.55198773G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 YUFARCI 2013606 1896238 skin NS NS NS malignant_melanoma NS NS NS y COSV51816429 COSM1698693 133218048 c.1675A>G p.N559D Substitution - Missense het 38 7:55165367-55165367 + - NEUTRAL .4812 Confirmed somatic variant 22842228 NS NS ENSP00000415559.1:p.Asn559Asp ENST00000455089.5:c.1675A>G 7:g.55165367A>G EGFR ENST00000275493.6 3633 3236 1312382 1312382 1223291 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 78 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 86564 1520630 1443005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51774667 COSM53194 133211250 c.2062C>T p.P688S Substitution - Missense 38 7:55174734-55174734 + - PATHOGENIC .99806 Confirmed somatic variant 20668451 NS primary ENSP00000415559.1:p.Pro688Ser ENST00000455089.5:c.2062C>T 7:g.55174734C>T EGFR ENST00000275493.6 3633 3236 TCGA-DU-6410-01 2194391 2062669 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 56 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1502208 1502208 1425087 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51790305 COSM13194 99378747 c.2540C>T p.T847I Substitution - Missense het 38 7:55191789-55191789 + - PATHOGENIC .95119 Confirmed somatic variant 21457545 surgery-fixed NS ENSP00000275493.2:p.Thr847Ile ENST00000275493.6:c.2540C>T 7:g.55191789C>T EGFR ENST00000275493.6 3633 3236 PL9 2492972 2355586 breast NS NS NS carcinoma lobular_carcinoma pleomorphic NS y COSV105110769 COSM9569122 99441949 c.212A>C p.Q71P Substitution - Missense 38 7:55142409-55142409 + - PATHOGENIC .94041 Confirmed somatic variant 26907767 surgery fresh/frozen primary ENSP00000275493.2:p.Gln71Pro ENST00000275493.6:c.212A>C 7:g.55142409A>C EGFR ENST00000275493.6 3633 3236 TCGA-K4-A3WU-01 2193299 2061577 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51793030 COSM133566 99411956 c.2507G>A p.R836H Substitution - Missense 38 7:55191756-55191756 + - PATHOGENIC .98912 Confirmed somatic variant 413 NS NS 87 ENSP00000275493.2:p.Arg836His ENST00000275493.6:c.2507G>A 7:g.55191756G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1122170 1122170 1035214 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51775222 COSM13189 132558076 c.2216C>T p.S739F Substitution - Missense het 38 7:55181360-55181360 + - PATHOGENIC .94833 Confirmed somatic variant 18379371 surgery - NOS primary 48 ENSP00000395243.3:p.Ser739Phe ENST00000454757.6:c.2216C>T 7:g.55181360C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1122170 1122170 1035214 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51767182 COSM27110 132554778 c.2221G>A p.V741M Substitution - Missense het 38 7:55181365-55181365 + - PATHOGENIC .97319 Confirmed somatic variant 18379371 surgery - NOS primary 48 ENSP00000395243.3:p.Val741Met ENST00000454757.6:c.2221G>A 7:g.55181365G>A EGFR ENST00000275493.6 3633 3236 1048202 1048202 964430 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17238183 surgery fresh/frozen NS 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876625 2876625 2731140 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006363-T01-IM5 2722740 2581561 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 133205223 c.731C>A p.A244D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Ala244Asp ENST00000455089.5:c.731C>A 7:g.55154129C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006363-T01-IM5 2722740 2581561 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152696 2152696 2021706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152696 2152696 2021706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812104 2812104 2668562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 31534501 pleural effusion NS 80 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812104 2812104 2668562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 31534501 pleural effusion NS 80 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 920114 920114 837193 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773712 COSM13433 99385694 c.2318A>G p.H773R Substitution - Missense hom 38 7:55181327-55181327 + - PATHOGENIC .98391 Confirmed somatic variant 15623594 surgery-fixed NS 66 ENSP00000275493.2:p.His773Arg ENST00000275493.6:c.2318A>G 7:g.55181327A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152780 2152780 2021790 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009183-T01-IM5 2725158 2583979 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51786644 COSM6967269 132569681 c.3065A>T p.Q1022L Substitution - Missense het 38 7:55202554-55202554 + - PATHOGENIC .85028 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gln1022Leu ENST00000454757.6:c.3065A>T 7:g.55202554A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006758-T01-IM5 2723137 2581958 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51797815 COSM6953729 132578460 c.1732A>C p.N578H Substitution - Missense het 38 7:55165424-55165424 + - PATHOGENIC .99714 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Asn578His ENST00000454757.6:c.1732A>C 7:g.55165424A>C EGFR ENST00000275493.6 3633 3236 W016-S1 2732510 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51785510 COSM6957413 99373603 c.1102G>A p.D368N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000275493.2:p.Asp368Asn ENST00000275493.6:c.1102G>A 7:g.55156628G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-YG-AA3N-01 2339750 2204733 skin NS NS NS malignant_melanoma NS NS NS y COSV51794869 COSM4362780 133204758 c.439C>T p.P147S Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 540 NS primary 67 ENSP00000415559.1:p.Pro147Ser ENST00000455089.5:c.439C>T 7:g.55151308C>T EGFR ENST00000275493.6 3633 3236 W016-S1 2732510 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2758916 2758916 2617466 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 23435014 surgery fresh/frozen NS 60.2 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982873 982873 898592 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152700 2152700 2021710 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152700 2152700 2021710 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780783 COSM20817 132574951 c.1972C>G p.L658V Substitution - Missense 38 7:55173966-55173966 + - PATHOGENIC .96619 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu658Val ENST00000454757.6:c.1972C>G 7:g.55173966C>G EGFR ENST00000275493.6 3633 3236 1044281 1044281 960622 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 65 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008083-T01-IM5 2724269 2583090 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 132551401 c.2192G>A p.R731H Substitution - Missense het 38 7:55181336-55181336 + - PATHOGENIC .981 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000395243.3:p.Arg731His ENST00000454757.6:c.2192G>A 7:g.55181336G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008514-T01-IM5 2724609 2583430 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51780877 COSM26717 132548732 c.2444A>T p.K815I Substitution - Missense het 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Lys815Ile ENST00000454757.6:c.2444A>T 7:g.55191828A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008514-T01-IM5 2724609 2583430 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920042 920042 837121 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 15623594 surgery fresh/frozen NS 71 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920042 920042 837121 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15623594 surgery fresh/frozen NS 71 ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003495-T01-IM5 2719974 2578795 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 133205309 c.2104_2105delinsCC p.L702P Substitution - Missense het 38 7:55174776-55174777 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu702Pro ENST00000455089.5:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR ENST00000275493.6 3633 3236 1004811 1004811 922023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16140420 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211141 1211141 1123009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 60 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 16925 1423760 1333788 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 132551897 c.2447T>G p.L816R Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Leu816Arg ENST00000454757.6:c.2447T>G 7:g.55191831T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010247-T01-IM5 2726036 2584857 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010247-T01-IM5 2726036 2584857 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006003-T01-IM5 2722386 2581207 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006003-T01-IM5 2722386 2581207 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2812068 2812068 2668544 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 pleural effusion NS 44 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2115504 2115504 1989748 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1486991 1486991 1410609 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51784752 COSM13199 132549074 c.2483G>A p.G828E Substitution - Missense 38 7:55191867-55191867 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 59 ENSP00000395243.3:p.Gly828Glu ENST00000454757.6:c.2483G>A 7:g.55191867G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1486991 1486991 1410609 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51777202 COSM20896 132585150 c.2365G>A p.V789M Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 59 ENSP00000395243.3:p.Val789Met ENST00000454757.6:c.2365G>A 7:g.55191749G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011269-T01-IM5 2726879 2585700 skin NS NS NS malignant_melanoma NS NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 2811985 2811985 2668504 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 57 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007508-T01-IM5 2723793 2582614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1317185 1317185 1228086 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20126411 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152778 2152778 2021788 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982783 982783 898502 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51868328 COSM18422 99447455 c.2360A>G p.Q787R Substitution - Missense 38 7:55181369-55181369 + - PATHOGENIC .9793 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Gln787Arg ENST00000275493.6:c.2360A>G 7:g.55181369A>G EGFR ENST00000275493.6 3633 3236 982783 982783 898502 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982865 982865 898584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CHG-13-09089T 2634309 2494705 liver NS NS NS other neoplasm NS NS y COSV51858993 COSM6253894 99436515 c.3006G>T p.M1002I Substitution - Missense 38 7:55201247-55201247 + - PATHOGENIC .94822 Confirmed somatic variant 660 NS primary 67 ENSP00000275493.2:p.Met1002Ile ENST00000275493.6:c.3006G>T 7:g.55201247G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000900-T01-IM3 2716219 2575040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1460113 1460113 1383990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51806104 COSM52932 99381585 c.2266A>T p.N756Y Substitution - Missense 38 7:55174803-55174803 + - PATHOGENIC .99468 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000275493.2:p.Asn756Tyr ENST00000275493.6:c.2266A>T 7:g.55174803A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S001103 1027689 944665 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 132551880 c.652A>C p.T218P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Thr218Pro ENST00000454757.6:c.652A>C 7:g.55154050A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 J11 2815385 2671765 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 29263181 surgery fresh/frozen NS 50 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 4577 915975 833374 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 HCC41 2120840 1995076 liver NS NS NS carcinoma NS NS NS y COSV51780707 COSM1251019 132568401 c.3323G>T p.S1108I Substitution - Missense 38 7:55205442-55205442 + - NEUTRAL .36171 Confirmed somatic variant 323 NS NS ENSP00000395243.3:p.Ser1108Ile ENST00000454757.6:c.3323G>T 7:g.55205442G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A103-T-S13 2757416 2616003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811944 2811944 2668490 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 55 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EE-A29S-06 2121645 1995881 skin NS NS NS malignant_melanoma NS NS NS y COSV51772666 COSM3412205 132552119 c.2812G>A p.G938R Substitution - Missense 38 7:55201188-55201188 + - PATHOGENIC .98883 Confirmed somatic variant 540 NS NS 79 ENSP00000395243.3:p.Gly938Arg ENST00000454757.6:c.2812G>A 7:g.55201188G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876614 2876614 2731129 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 132551512 c.2113G>C p.A705P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Confirmed somatic variant 29506987 circulating tumour NS 58 ENSP00000395243.3:p.Ala705Pro ENST00000454757.6:c.2113G>C 7:g.55174785G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876614 2876614 2731129 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 132557758 c.2018T>A p.L673Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Confirmed somatic variant 29506987 circulating tumour NS 58 ENSP00000395243.3:p.Leu673Gln ENST00000454757.6:c.2018T>A 7:g.55174012T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002022-T01-IM3 2718329 2577150 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 133208833 c.619C>T p.R207C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg207Cys ENST00000455089.5:c.619C>T 7:g.55154017C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008601-T01-IM5 2724703 2583524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008601-T01-IM5 2724703 2583524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LU-1516 2478818 2341580 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22510280 NS primary 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0002124-T01-IM3 2829436 2685251 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51806564 COSM6920868 99383183 c.2006G>A p.R669Q Substitution - Missense 38 7:55173069-55173069 + - PATHOGENIC .99699 Confirmed somatic variant 30205045 surgery-fixed metastasis 53 ENSP00000275493.2:p.Arg669Gln ENST00000275493.6:c.2006G>A 7:g.55173069G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004208-T01-IM5 2720615 2579436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 914585 914585 832034 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 80 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0003116-T02-IM5 2719611 2578432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51809537 COSM6926377 99391213 c.3041A>T p.D1014V Substitution - Missense het 38 7:55201282-55201282 + - PATHOGENIC .99519 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Asp1014Val ENST00000275493.6:c.3041A>T 7:g.55201282A>T EGFR ENST00000275493.6 3633 3236 P-0003116-T02-IM5 2719611 2578432 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A014-T-S21 2758133 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1909609 1909609 1798129 oesophagus NS NS NS carcinoma carcinosarcoma NS NS n COSV51773932 COSM1272071 99400111 c.2368A>G p.T790A Substitution - Missense 38 7:55181377-55181377 + - PATHOGENIC .9793 Confirmed somatic variant 23546020 fixed - NOS NS ENSP00000275493.2:p.Thr790Ala ENST00000275493.6:c.2368A>G 7:g.55181377A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594191 1594191 1515165 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51799836 COSM133563 133217191 c.2159T>G p.V720G Substitution - Missense het 38 7:55181303-55181303 + - PATHOGENIC .97973 Confirmed somatic variant 19726454 surgery fresh/frozen primary 58 ENSP00000415559.1:p.Val720Gly ENST00000455089.5:c.2159T>G 7:g.55181303T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2696712 2696712 2555616 oesophagus NS NS NS other metaplasia epidermoid NS n COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28731047 surgery-fixed primary 65 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 982792 982792 898511 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206768 1206768 1118646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EXTERN_MELA_20140530_022 2839470 2695236 skin lip NS NS malignant_melanoma NS NS NS y COSV104577007 COSM9448763 132574076 c.1799C>T p.S600F Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99547 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000395243.3:p.Ser600Phe ENST00000454757.6:c.1799C>T 7:g.55172997C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T2565 2658399 2518558 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51771628 COSM1205054 133207482 c.1876C>T p.R626C Substitution - Missense 38 7:55173074-55173074 + - PATHOGENIC .99716 Confirmed somatic variant 27149842 NS NS 66.25 ENSP00000415559.1:p.Arg626Cys ENST00000455089.5:c.1876C>T 7:g.55173074C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011240-T01-IM5 2726852 2585673 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765999 COSM3266658 132575022 c.3071A>G p.Y1024C Substitution - Missense het 38 7:55202560-55202560 + - PATHOGENIC .97752 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Tyr1024Cys ENST00000454757.6:c.3071A>G 7:g.55202560A>G EGFR ENST00000275493.6 3633 3236 CHG-13-09089T 2634309 2494705 liver NS NS NS other neoplasm NS NS y COSV51811749 COSM6242 99389560 c.2305G>T p.V769L Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .9836 Confirmed somatic variant 660 NS primary 67 ENSP00000275493.2:p.Val769Leu ENST00000275493.6:c.2305G>T 7:g.55181314G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811938 2811938 2668488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour metastasis 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S02347_1 2480908 2343653 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV51836148 COSM5694347 132565772 c.2543A>G p.H848R Substitution - Missense 38 7:55192818-55192818 + - PATHOGENIC .96101 Confirmed somatic variant 26168399 surgery fresh/frozen metastasis 67 ENSP00000395243.3:p.His848Arg ENST00000454757.6:c.2543A>G 7:g.55192818A>G EGFR ENST00000275493.6 3633 3236 EXTERN_MELA_20140524_012 2839317 2695083 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51776559 COSM4892884 99381163 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000275493.2:p.Pro100Ser ENST00000275493.6:c.298C>T 7:g.55143362C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PT36 2521293 2383636 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV51784241 COSM5915646 133243503 c.1055C>T p.T352I Substitution - Missense 38 7:55156815-55156815 + - PATHOGENIC .99038 Confirmed somatic variant 25759019 surgery fresh/frozen NS ENSP00000415559.1:p.Thr352Ile ENST00000455089.5:c.1055C>T 7:g.55156815C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-32-1979-01 2120345 1994581 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 132552126 c.674A>G p.Y225C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 329 NS NS 69 ENSP00000395243.3:p.Tyr225Cys ENST00000454757.6:c.674A>G 7:g.55154072A>G EGFR ENST00000275493.6 3633 3236 EXTERN_MELA_20140524_012 2839317 2695083 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 99381173 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000275493.2:p.Ser116Phe ENST00000275493.6:c.347C>T 7:g.55143411C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152766 2152766 2021776 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811957 2811957 2668495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed metastasis 79 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206721 1206721 1118599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G ABCC8_ENST00000647015 ENST00000647015.1 4497 59 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105879570 COSM10012873 177184543 c.1805T>C p.F602S Substitution - Missense 38 11:17427926-17427926 - - PATHOGENIC .98111 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000495389.1:p.Phe602Ser ENST00000647015.1:c.1805T>C 11:g.17427926A>G EGFR ENST00000275493.6 3633 3236 P-0008917-T01-IM5 2724934 2583755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0008917-T01-IM5 2724934 2583755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1179548 1179548 1091510 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 52 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152757 2152757 2021767 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51800786 COSM3734671 132580060 c.2128G>A p.A710T Substitution - Missense 38 7:55174800-55174800 + - PATHOGENIC .99476 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Ala710Thr ENST00000454757.6:c.2128G>A 7:g.55174800G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DCG_04 2664382 2524436 central_nervous_system cerebellum NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51838314 COSM6837033 132555086 c.1351G>A p.E451K Substitution - Missense 38 7:55160326-55160326 + - NEUTRAL .08736 Confirmed somatic variant 28852847 surgery fresh/frozen NS 40 ENSP00000395243.3:p.Glu451Lys ENST00000454757.6:c.1351G>A 7:g.55160326G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1502209 1502209 1425088 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51790305 COSM13194 132551901 c.2405C>T p.T802I Substitution - Missense het 38 7:55191789-55191789 + - PATHOGENIC .95119 Confirmed somatic variant 21457545 surgery-fixed NS ENSP00000395243.3:p.Thr802Ile ENST00000454757.6:c.2405C>T 7:g.55191789C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982859 982859 898578 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2865686 2865686 2720762 lung right_lower_lobe NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 27486332 surgery-fixed NS 50 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S001050 1027681 944657 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51835525 COSM21681 132586005 c.136G>A p.D46N Substitution - Missense het 38 7:55142333-55142333 + - PATHOGENIC .94315 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Asp46Asn ENST00000454757.6:c.136G>A 7:g.55142333G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S001050 1027681 944657 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51835541 COSM21682 132586011 c.187G>C p.G63R Substitution - Missense het 38 7:55142384-55142384 + - PATHOGENIC .9897 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Gly63Arg ENST00000454757.6:c.187G>C 7:g.55142384G>C EGFR ENST00000275493.6 3633 3236 2115510 2115510 1989754 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 YUFARCI 2013606 1896238 skin NS NS NS malignant_melanoma NS NS NS y COSV51816429 COSM1698693 99390361 c.1810A>G p.N604D Substitution - Missense het 38 7:55165367-55165367 + - NEUTRAL .4812 Confirmed somatic variant 22842228 NS NS ENSP00000275493.2:p.Asn604Asp ENST00000275493.6:c.1810A>G 7:g.55165367A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152769 2152769 2021779 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 86564 1520630 1443005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51774667 COSM53194 99382658 c.2197C>T p.P733S Substitution - Missense 38 7:55174734-55174734 + - PATHOGENIC .99806 Confirmed somatic variant 20668451 NS primary ENSP00000275493.2:p.Pro733Ser ENST00000275493.6:c.2197C>T 7:g.55174734C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 16 2630307 2490691 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51780766 COSM219795 133202085 c.2456C>T p.A819V Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .93098 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000415559.1:p.Ala819Val ENST00000455089.5:c.2456C>T 7:g.55191840C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 16 2630307 2490691 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51780760 COSM6196858 133229809 c.341A>G p.E114G Substitution - Missense 38 7:55143405-55143405 + - PATHOGENIC .99844 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000415559.1:p.Glu114Gly ENST00000455089.5:c.341A>G 7:g.55143405A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 16927 1423761 1333789 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0006363-T01-IM5 2722740 2581561 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 99377226 c.866C>A p.A289D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Ala289Asp ENST00000275493.6:c.866C>A 7:g.55154129C>A EGFR ENST00000275493.6 3633 3236 P-0006363-T01-IM5 2722740 2581561 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2152696 2152696 2021706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2152696 2152696 2021706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-VS057-T1 2869886 2724883 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105111245 COSM9804278 132548773 c.2840C>T p.P947L Substitution - Missense 38 7:55201216-55201216 + - PATHOGENIC .99346 Confirmed somatic variant 26950094 surgery - NOS NS 72 ENSP00000395243.3:p.Pro947Leu ENST00000454757.6:c.2840C>T 7:g.55201216C>T EGFR ENST00000275493.6 3633 3236 2152780 2152780 2021790 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006368-T01-IM5 2722745 2581566 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51843325 COSM6950386 133239997 c.967G>T p.D323Y Substitution - Missense het 38 7:55156628-55156628 + - PATHOGENIC .97349 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Asp323Tyr ENST00000455089.5:c.967G>T 7:g.55156628G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-0691-01 2178100 2046398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774829 COSM1451549 133204902 c.632A>G p.D211G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 329 NS NS 63 ENSP00000415559.1:p.Asp211Gly ENST00000455089.5:c.632A>G 7:g.55154030A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-VS060-T1 2869889 2724886 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110495 COSM9804381 132616547 c.2636C>T p.S879F Substitution - Missense 38 7:55198786-55198786 + - PATHOGENIC .98269 Confirmed somatic variant 26950094 surgery - NOS NS 74 ENSP00000395243.3:p.Ser879Phe ENST00000454757.6:c.2636C>T 7:g.55198786C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CSCC-7-T 2292460 2158524 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51852113 COSM4501266 132563348 c.449C>T p.P150L Substitution - Missense het 38 7:55151318-55151318 + - NEUTRAL .31382 Confirmed somatic variant 25303977 surgery fresh/frozen primary 60 ENSP00000395243.3:p.Pro150Leu ENST00000454757.6:c.449C>T 7:g.55151318C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001097-T02-IM5 2719393 2578214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-YG-AA3N-01 2339750 2204733 skin NS NS NS malignant_melanoma NS NS NS y COSV51794869 COSM4362780 99376586 c.574C>T p.P192S Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 540 NS primary 67 ENSP00000275493.2:p.Pro192Ser ENST00000275493.6:c.574C>T 7:g.55151308C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876612 2876612 2731127 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105110405 COSM9869915 132601866 c.2240T>G p.L747R Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .95324 Confirmed somatic variant 29506987 circulating tumour NS 73 ENSP00000395243.3:p.Leu747Arg ENST00000454757.6:c.2240T>G 7:g.55181384T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876612 2876612 2731127 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 73 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0003495-T01-IM5 2719974 2578795 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 99377339 c.2239_2240delinsCC p.L747P Substitution - Missense het 38 7:55174776-55174777 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu747Pro ENST00000275493.6:c.2239_2240delinsCC 7:g.55174776_55174777delinsCC EGFR ENST00000275493.6 3633 3236 1498501 1498501 1421379 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21040950 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001357-T02-IM5 2719416 2578237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812132 2812132 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51829458 COSM51497 132554096 c.2102_2103inv p.E701V Substitution - Missense 38 7:55174774-55174775 + - Confirmed somatic variant 31534501 pleural effusion NS 77 ENSP00000395243.3:p.Glu701Val ENST00000454757.6:c.2102_2103inv 7:g.55174774_55174775inv EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812132 2812132 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV99289025 COSM9179905 132554109 c.2116A>G p.T706A Substitution - Missense 38 7:55174788-55174788 + - PATHOGENIC .9946 Confirmed somatic variant 31534501 pleural effusion NS 77 ENSP00000395243.3:p.Thr706Ala ENST00000454757.6:c.2116A>G 7:g.55174788A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812132 2812132 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 pleural effusion NS 77 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0007508-T01-IM5 2723793 2582614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-VQ-A91D-01 2339968 2204951 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99289543 COSM8211280 132556784 c.3318C>A p.F1106L Substitution - Missense 38 7:55205437-55205437 + - NEUTRAL .20378 Confirmed somatic variant 541 NS primary 70 ENSP00000395243.3:p.Phe1106Leu ENST00000454757.6:c.3318C>A 7:g.55205437C>A EGFR ENST00000275493.6 3633 3236 4577 915975 833374 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002038-T01-IM3 2718344 2577165 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 132550443 c.2104_2105delinsCC p.L702P Substitution - Missense het 38 7:55174776-55174777 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu702Pro ENST00000454757.6:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876627 2876627 2731142 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 34 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010793-T01-IM5 2726461 2585282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010793-T01-IM5 2726461 2585282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005261-T01-IM5 2721660 2580481 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51861444 COSM13007 132548215 c.2200_2201delinsTT p.G734F Substitution - Missense het 38 7:55181344-55181345 + - Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Gly734Phe ENST00000454757.6:c.2200_2201delinsTT 7:g.55181344_55181345delinsTT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1472950 1472950 1396649 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51820767 COSM53288 132556058 c.2219C>T p.T740I Substitution - Missense 38 7:55181363-55181363 + - PATHOGENIC .9109 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000395243.3:p.Thr740Ile ENST00000454757.6:c.2219C>T 7:g.55181363C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 C086 2465276 2328109 NS NS NS NS malignant_melanoma NS NS NS y COSV51845994 COSM5530405 133202750 c.1498G>A p.E500K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 23890154 cell-line metastasis ENSP00000415559.1:p.Glu500Lys ENST00000455089.5:c.1498G>A 7:g.55163734G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008179-T01-IM5 2830114 2685929 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 132553945 c.1639G>A p.V547I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000395243.3:p.Val547Ile ENST00000454757.6:c.1639G>A 7:g.55165331G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-0619-01 1909590 1798111 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 fresh/frozen - NOS primary 60 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460097 1460097 1383974 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471538 1471538 1395277 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2811944 2811944 2668490 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 55 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1468561 1468561 1392312 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 1468561 1468561 1392312 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 P-0002022-T01-IM3 2718329 2577150 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 99380629 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg252Cys ENST00000275493.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-55-A48Z-01 2194757 2063035 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 417 NS NS 60 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920027 920027 837106 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BB-8596-01 2193542 2061820 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99289667 COSM8311578 133244367 c.1372G>A p.G458S Substitution - Missense 38 7:55161507-55161507 + - NEUTRAL .07845 Confirmed somatic variant 627 NS NS 69 ENSP00000415559.1:p.Gly458Ser ENST00000455089.5:c.1372G>A 7:g.55161507G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1505373 1505373 1428248 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1109726 1109726 1023636 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD36140a 2894853 2749341 skin extremity NS NS malignant_melanoma nodular NS NS y COSV105110902 COSM9873684 133244185 c.2171T>G p.V724G Substitution - Missense 38 7:55181315-55181315 + - PATHOGENIC .97973 Confirmed somatic variant 33024263 surgery-fixed metastasis 50 ENSP00000415559.1:p.Val724Gly ENST00000455089.5:c.2171T>G 7:g.55181315T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002105-T01-IM3 2718403 2577224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51844520 COSM6920741 133229344 c.504C>G p.I168M Substitution - Missense het 38 7:55152556-55152556 + - PATHOGENIC .89498 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ile168Met ENST00000455089.5:c.504C>G 7:g.55152556C>G EGFR ENST00000275493.6 3633 3236 2696712 2696712 2555616 oesophagus NS NS NS other metaplasia epidermoid NS n COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28731047 surgery-fixed primary 65 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0155 2107953 1985814 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 133206295 c.775C>T p.H259Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.His259Tyr ENST00000455089.5:c.775C>T 7:g.55155850C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 B105-0 2097254 1975318 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV51776529 COSM1755314 132592444 c.1745G>A p.G582E Substitution - Missense 38 7:55165437-55165437 + - PATHOGENIC .99581 Confirmed somatic variant 24121792 fresh/frozen - NOS NS ENSP00000395243.3:p.Gly582Glu ENST00000454757.6:c.1745G>A 7:g.55165437G>A EGFR ENST00000275493.6 3633 3236 1594191 1594191 1515165 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51799836 COSM133563 99389334 c.2294T>G p.V765G Substitution - Missense het 38 7:55181303-55181303 + - PATHOGENIC .97973 Confirmed somatic variant 19726454 surgery fresh/frozen primary 58 ENSP00000275493.2:p.Val765Gly ENST00000275493.6:c.2294T>G 7:g.55181303T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812001 2812001 2668509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489260 1489260 1412418 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000378-T01-IM3 2715158 2573979 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849115 COSM6910123 133224254 c.580G>T p.G194C Substitution - Missense het 38 7:55152632-55152632 + - PATHOGENIC .99578 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly194Cys ENST00000455089.5:c.580G>T 7:g.55152632G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000378-T01-IM3 2715158 2573979 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 133220832 c.1658G>C p.G553A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly553Ala ENST00000455089.5:c.1658G>C 7:g.55165350G>C EGFR ENST00000275493.6 3633 3236 T2565 2658399 2518558 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51771628 COSM1205054 99379331 c.2011C>T p.R671C Substitution - Missense 38 7:55173074-55173074 + - PATHOGENIC .99716 Confirmed somatic variant 27149842 NS NS 66.25 ENSP00000275493.2:p.Arg671Cys ENST00000275493.6:c.2011C>T 7:g.55173074C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PM01M 2653316 2513443 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS metastasis 48.07 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001613-T02-IM5 2719442 2578263 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2864406 2864406 2719564 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 31761448 circulating tumour recurrent 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2864406 2864406 2719564 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 31761448 circulating tumour recurrent 53 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2811938 2811938 2668488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour metastasis 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G LAMA1 ENST00000389658.3 9228 6481 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105933204 COSM10012939 116843892 c.1939G>A p.D647N Substitution - Missense 38 18:7034591-7034591 - - PATHOGENIC .97457 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000374309.3:p.Asp647Asn ENST00000389658.3:c.1939G>A 18:g.7034591C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000788-T01-IM3 2715990 2574811 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2012-695:2012-1303-T 2297791 2163392 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51840606 COSM4605183 99395965 c.3472G>C p.A1158P Substitution - Missense hom 38 7:55205456-55205456 + - PATHOGENIC .80039 Confirmed somatic variant 25056374 surgery-fixed NS ENSP00000275493.2:p.Ala1158Pro ENST00000275493.6:c.3472G>C 7:g.55205456G>C EGFR ENST00000275493.6 3633 3236 2152766 2152766 2021776 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2811957 2811957 2668495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed metastasis 79 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 56 898379 815991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206721 1206721 1118599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811984 2811984 2668504 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed NS 57 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 PT36 2521293 2383636 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV51784241 COSM5915646 99418258 c.1190C>T p.T397I Substitution - Missense 38 7:55156815-55156815 + - PATHOGENIC .99038 Confirmed somatic variant 25759019 surgery fresh/frozen NS ENSP00000275493.2:p.Thr397Ile ENST00000275493.6:c.1190C>T 7:g.55156815C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MB-T29 2802988 2659798 breast NS NS NS carcinoma ER-PR-positive_carcinoma NS NS n COSV51836185 COSM4884832 132575704 c.604G>T p.D202Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 26960396 fixed - NOS NS 83 ENSP00000395243.3:p.Asp202Tyr ENST00000454757.6:c.604G>T 7:g.55152656G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-14-1456-01 1338007 1248392 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 23 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001193-T01-IM3 2716798 2575619 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV51852240 COSM6915314 132552823 c.332T>C p.M111T Substitution - Missense het 38 7:55143396-55143396 + - PATHOGENIC .8651 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Met111Thr ENST00000454757.6:c.332T>C 7:g.55143396T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009311-T01-IM5 2725257 2584078 skin NS NS NS malignant_melanoma NS NS NS n COSV51862353 COSM6968107 132569686 c.2591C>T p.T864I Substitution - Missense het 38 7:55198741-55198741 + - PATHOGENIC .98954 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr864Ile ENST00000454757.6:c.2591C>T 7:g.55198741C>T EGFR ENST00000275493.6 3633 3236 2115536 2115536 1989780 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2492722 2492722 2355337 skin NS NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 132556505 c.2890G>A p.D964N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000395243.3:p.Asp964Asn ENST00000454757.6:c.2890G>A 7:g.55201266G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 WG05M 2653266 2513393 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS metastasis 58.29 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152769 2152769 2021779 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000774-T01-IM3 2715962 2574783 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 16 2630307 2490691 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51780766 COSM219795 99373292 c.2591C>T p.A864V Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .93098 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000275493.2:p.Ala864Val ENST00000275493.6:c.2591C>T 7:g.55191840C>T EGFR ENST00000275493.6 3633 3236 16 2630307 2490691 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51780760 COSM6196858 99404051 c.341A>G p.E114G Substitution - Missense 38 7:55143405-55143405 + - PATHOGENIC .99844 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000275493.2:p.Glu114Gly ENST00000275493.6:c.341A>G 7:g.55143405A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003923-T01-IM5 2720399 2579220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51793896 COSM22954 132561366 c.2189G>A p.C730Y Substitution - Missense het 38 7:55181333-55181333 + - PATHOGENIC .97278 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Cys730Tyr ENST00000454757.6:c.2189G>A 7:g.55181333G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003923-T01-IM5 2720399 2579220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003923-T01-IM5 2720399 2579220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003923-T01-IM5 2720399 2579220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1322278 1322278 1233165 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 59 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 RPMI-8226 1998470 1883542 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV51773111 COSM13185 132548474 c.2117C>T p.T706I Substitution - Missense het 38 7:55174789-55174789 + - PATHOGENIC .99151 Confirmed somatic variant 23856246 cell-line primary ENSP00000395243.3:p.Thr706Ile ENST00000454757.6:c.2117C>T 7:g.55174789C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008777-T01-IM5 2724826 2583647 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T NOX5_ENST00000530406 ENST00000530406.6 2214 14874 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105871370 COSM10012832 150520043 c.1103A>T p.E368V Substitution - Missense 38 15:69035935-69035935 + - PATHOGENIC .81287 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000432440.2:p.Glu368Val ENST00000530406.6:c.1103A>T 15:g.69035935A>T EGFR ENST00000275493.6 3633 3236 P-0006368-T01-IM5 2722745 2581566 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51843325 COSM6950386 99413754 c.1102G>T p.D368Y Substitution - Missense het 38 7:55156628-55156628 + - PATHOGENIC .97349 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Asp368Tyr ENST00000275493.6:c.1102G>T 7:g.55156628G>T EGFR ENST00000275493.6 3633 3236 TCGA-12-0691-01 2178100 2046398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774829 COSM1451549 99376761 c.767A>G p.D256G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 329 NS NS 63 ENSP00000275493.2:p.Asp256Gly ENST00000275493.6:c.767A>G 7:g.55154030A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-92-6393-Tumor-SM-7CKB6 2640208 2500509 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma NS NS y COSV51802220 COSM6458155 132548895 c.805G>A p.D269N Substitution - Missense 38 7:55155880-55155880 + - PATHOGENIC .94623 Confirmed somatic variant 28098136 surgery-fixed primary 65 ENSP00000395243.3:p.Asp269Asn ENST00000454757.6:c.805G>A 7:g.55155880G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-13-0919-01 1475027 1398726 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51781063 COSM115794 132596968 c.2180C>G p.P727R Substitution - Missense het 38 7:55181324-55181324 + - PATHOGENIC .97777 Confirmed somatic variant 21720365 331 NS primary 52 ENSP00000395243.3:p.Pro727Arg ENST00000454757.6:c.2180C>G 7:g.55181324C>G EGFR ENST00000275493.6 3633 3236 1052779 1052779 968850 soft_tissue fibrous_tissue_and_uncertain_origin NS NS synovial_sarcoma monophasic NS NS n COSM24273 178386680 c.? p.R748K Substitution - Missense + - Confirmed somatic variant 17376509 surgery - NOS NS ENSP00000275493.2:p.Arg748Lys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A103-T-S19 2757417 2616003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-27-1838-01 1338063 1248448 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 132550339 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000395243.3:p.Ala244Asp ENST00000454757.6:c.731C>A 7:g.55154129C>A EGFR ENST00000275493.6 3633 3236 P-0001097-T02-IM5 2719393 2578214 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001257 1001257 918480 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0001357-T02-IM5 2719416 2578237 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1468638 1468638 1392389 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003967-T01-IM5 2720417 2579238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-1804-01 2120260 1994496 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51855357 COSM3412180 132586849 c.631G>T p.D211Y Substitution - Missense 38 7:55154029-55154029 + - PATHOGENIC .9742 Confirmed somatic variant 329 NS NS 81 ENSP00000395243.3:p.Asp211Tyr ENST00000454757.6:c.631G>T 7:g.55154029G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008343-T01-IM5 2724471 2583292 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS n COSV51790148 COSM22555 133209794 c.1895G>A p.R632H Substitution - Missense het 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg632His ENST00000455089.5:c.1895G>A 7:g.55173093G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2014_Lung_sq_14_T 2744885 2603588 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 58 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-B7-A5TI-01 2457338 2320175 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99290867 COSM8197349 133234689 c.2623G>T p.A875S Substitution - Missense 38 7:55198773-55198773 + - PATHOGENIC .98826 Confirmed somatic variant 541 NS primary 52 ENSP00000415559.1:p.Ala875Ser ENST00000455089.5:c.2623G>T 7:g.55198773G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1122170 1122170 1035214 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51775222 COSM13189 133214176 c.2216C>T p.S739F Substitution - Missense het 38 7:55181360-55181360 + - PATHOGENIC .94833 Confirmed somatic variant 18379371 surgery - NOS primary 48 ENSP00000415559.1:p.Ser739Phe ENST00000455089.5:c.2216C>T 7:g.55181360C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1122170 1122170 1035214 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51767182 COSM27110 133210338 c.2221G>A p.V741M Substitution - Missense het 38 7:55181365-55181365 + - PATHOGENIC .97319 Confirmed somatic variant 18379371 surgery - NOS primary 48 ENSP00000415559.1:p.Val741Met ENST00000455089.5:c.2221G>A 7:g.55181365G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812104 2812104 2668562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 31534501 pleural effusion NS 80 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812104 2812104 2668562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 31534501 pleural effusion NS 80 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876664 2876664 2731179 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 37 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005985-T01-IM5 2722368 2581189 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009183-T01-IM5 2725158 2583979 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51786644 COSM6967269 133227118 c.3065A>T p.Q1022L Substitution - Missense het 38 7:55202554-55202554 + - PATHOGENIC .85028 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gln1022Leu ENST00000455089.5:c.3065A>T 7:g.55202554A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006758-T01-IM5 2723137 2581958 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51797815 COSM6953729 133238774 c.1732A>C p.N578H Substitution - Missense het 38 7:55165424-55165424 + - PATHOGENIC .99714 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Asn578His ENST00000455089.5:c.1732A>C 7:g.55165424A>C EGFR ENST00000275493.6 3633 3236 2876627 2876627 2731142 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 34 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2758916 2758916 2617466 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 23435014 surgery fresh/frozen NS 60.2 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-14-0790-01 1337989 1248374 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 64 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152700 2152700 2021710 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152700 2152700 2021710 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780783 COSM20817 133233676 c.1972C>G p.L658V Substitution - Missense 38 7:55173966-55173966 + - PATHOGENIC .96619 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu658Val ENST00000455089.5:c.1972C>G 7:g.55173966C>G EGFR ENST00000275493.6 3633 3236 1471538 1471538 1395277 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1460097 1460097 1383974 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008514-T01-IM5 2724609 2583430 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51780877 COSM26717 133203719 c.2444A>T p.K815I Substitution - Missense het 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Lys815Ile ENST00000455089.5:c.2444A>T 7:g.55191828A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008514-T01-IM5 2724609 2583430 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008083-T01-IM5 2724269 2583090 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 133206317 c.2192G>A p.R731H Substitution - Missense het 38 7:55181336-55181336 + - PATHOGENIC .981 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000415559.1:p.Arg731His ENST00000455089.5:c.2192G>A 7:g.55181336G>A EGFR ENST00000275493.6 3633 3236 920027 920027 837106 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-55-A48Z-01 2194757 2063035 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 417 NS NS 60 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1505373 1505373 1428248 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-BB-8596-01 2193542 2061820 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99289667 COSM8311578 99419268 c.1507G>A p.G503S Substitution - Missense 38 7:55161507-55161507 + - NEUTRAL .07845 Confirmed somatic variant 627 NS NS 69 ENSP00000275493.2:p.Gly503Ser ENST00000275493.6:c.1507G>A 7:g.55161507G>A EGFR ENST00000275493.6 3633 3236 PD36140a 2894853 2749341 skin extremity NS NS malignant_melanoma nodular NS NS y COSV105110902 COSM9873684 99419063 c.2306T>G p.V769G Substitution - Missense 38 7:55181315-55181315 + - PATHOGENIC .97973 Confirmed somatic variant 33024263 surgery-fixed metastasis 50 ENSP00000275493.2:p.Val769Gly ENST00000275493.6:c.2306T>G 7:g.55181315T>G EGFR ENST00000275493.6 3633 3236 P-0002105-T01-IM3 2718403 2577224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51844520 COSM6920741 99403525 c.639C>G p.I213M Substitution - Missense het 38 7:55152556-55152556 + - PATHOGENIC .89498 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ile213Met ENST00000275493.6:c.639C>G 7:g.55152556C>G EGFR ENST00000275493.6 3633 3236 TCGA-06-0155 2107953 1985814 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 99378201 c.910C>T p.H304Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.His304Tyr ENST00000275493.6:c.910C>T 7:g.55155850C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920042 920042 837121 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15623594 surgery fresh/frozen NS 71 ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920042 920042 837121 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 15623594 surgery fresh/frozen NS 71 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001226 1001226 918449 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51780783 COSM20817 132574951 c.1972C>G p.L658V Substitution - Missense 38 7:55173966-55173966 + - PATHOGENIC .96619 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu658Val ENST00000454757.6:c.1972C>G 7:g.55173966C>G EGFR ENST00000275493.6 3633 3236 2115519 2115519 1989763 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 C1409280774 2861656 2716876 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 27247954 pleural effusion NS 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 C1409280774 2861656 2716876 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 27247954 pleural effusion NS 67 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0000378-T01-IM3 2715158 2573979 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 99393769 c.1793G>C p.G598A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly598Ala ENST00000275493.6:c.1793G>C 7:g.55165350G>C EGFR ENST00000275493.6 3633 3236 P-0000378-T01-IM3 2715158 2573979 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849115 COSM6910123 99399015 c.715G>T p.G239C Substitution - Missense het 38 7:55152632-55152632 + - PATHOGENIC .99578 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly239Cys ENST00000275493.6:c.715G>T 7:g.55152632G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211141 1211141 1123009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 60 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 16925 1423760 1333788 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 133206840 c.2447T>G p.L816R Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Leu816Arg ENST00000455089.5:c.2447T>G 7:g.55191831T>G EGFR ENST00000275493.6 3633 3236 P-0001613-T02-IM5 2719442 2578263 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010247-T01-IM5 2726036 2584857 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-X6-A7WB-01 2270285 2137053 soft_tissue NS NS NS sarcoma NS NS NS y COSV99286478 COSM8460648 99424117 c.3546G>T p.K1182N Substitution - Missense 38 7:55205530-55205530 + - PATHOGENIC .81374 Confirmed somatic variant 635 NS NS ENSP00000275493.2:p.Lys1182Asn ENST00000275493.6:c.3546G>T 7:g.55205530G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010247-T01-IM5 2726036 2584857 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006003-T01-IM5 2722386 2581207 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006003-T01-IM5 2722386 2581207 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1486991 1486991 1410609 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51784752 COSM13199 133204015 c.2483G>A p.G828E Substitution - Missense 38 7:55191867-55191867 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 59 ENSP00000415559.1:p.Gly828Glu ENST00000455089.5:c.2483G>A 7:g.55191867G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1486991 1486991 1410609 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51777202 COSM20896 133246500 c.2365G>A p.V789M Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 59 ENSP00000415559.1:p.Val789Met ENST00000455089.5:c.2365G>A 7:g.55191749G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011269-T01-IM5 2726879 2585700 skin NS NS NS malignant_melanoma NS NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 C086 2465276 2328109 NS NS NS NS malignant_melanoma NS NS NS y COSV51846033 COSM5530399 133226145 c.2621C>T p.P874L Substitution - Missense 38 7:55198771-55198771 + - PATHOGENIC .97363 Confirmed somatic variant 23890154 cell-line metastasis ENSP00000415559.1:p.Pro874Leu ENST00000455089.5:c.2621C>T 7:g.55198771C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876653 2876653 2731168 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005009 1005009 922221 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 C086 2465276 2328109 NS NS NS NS malignant_melanoma NS NS NS y COSV51845994 COSM5530405 99374106 c.1633G>A p.E545K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 23890154 cell-line metastasis ENSP00000275493.2:p.Glu545Lys ENST00000275493.6:c.1633G>A 7:g.55163734G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152778 2152778 2021788 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-VQ-A8PX-01 2339506 2204489 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99285314 COSM8202780 132575034 c.536G>A p.R179H Substitution - Missense 38 7:55152588-55152588 + - PATHOGENIC .91275 Confirmed somatic variant 541 NS primary 51 ENSP00000395243.3:p.Arg179His ENST00000454757.6:c.536G>A 7:g.55152588G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876628 2876628 2731143 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 surgery fresh/frozen NS 52 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982865 982865 898584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010995-T01-IM5 2726638 2585459 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51806727 COSM6978402 132559850 c.2183_2185delinsTCA p.H728_V729delinsLM Substitution - Missense het 38 7:55181327-55181329 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.His728_Val729delinsLeuMet ENST00000454757.6:c.2183_2185delinsTCA 7:g.55181327_55181329delinsTCA EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000944-T01-IM3 2716313 2575134 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51841863 COSM6913649 132550692 c.3280C>T p.L1094F Substitution - Missense het 38 7:55205399-55205399 + - PATHOGENIC .96614 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu1094Phe ENST00000454757.6:c.3280C>T 7:g.55205399C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000900-T01-IM3 2716219 2575040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 XHDG51C 2321278 2186432 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS n COSV51818388 COSM53104 132574245 c.2255G>A p.C752Y Substitution - Missense 38 7:55181399-55181399 + - PATHOGENIC .98244 Confirmed somatic variant 24997986 NS NS 56 ENSP00000395243.3:p.Cys752Tyr ENST00000454757.6:c.2255G>A 7:g.55181399G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BC79-tumour 2668206 2527786 breast NS NS NS carcinoma NS NS NS y COSV51792227 COSM6582372 132554391 c.2524T>A p.L842I Substitution - Missense het 38 7:55192799-55192799 + - PATHOGENIC .84827 Confirmed somatic variant 27535334 surgery fresh/frozen metastasis ENSP00000395243.3:p.Leu842Ile ENST00000454757.6:c.2524T>A 7:g.55192799T>A EGFR ENST00000275493.6 3633 3236 WG05M 2653266 2513393 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS metastasis 58.29 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S001103 1027689 944665 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 133206822 c.652A>C p.T218P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Thr218Pro ENST00000455089.5:c.652A>C 7:g.55154050A>C EGFR ENST00000275493.6 3633 3236 P-0000774-T01-IM3 2715962 2574783 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 J11 2815385 2671765 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 29263181 surgery fresh/frozen NS 50 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV99293869 COSM8151148 132579978 c.973C>A p.H325N Substitution - Missense 38 7:55156634-55156634 + - NEUTRAL .19929 Confirmed somatic variant 540 NS NS 37 ENSP00000395243.3:p.His325Asn ENST00000454757.6:c.973C>A 7:g.55156634C>A EGFR ENST00000275493.6 3633 3236 1312389 1312389 1223298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 54 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A103-T-S13 2757416 2616003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1468624 1468624 1392375 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001124-T01-IM3 2716673 2575494 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51781531 COSM6914964 132567133 c.515A>T p.Q172L Substitution - Missense het 38 7:55152567-55152567 + - PATHOGENIC .9889 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gln172Leu ENST00000454757.6:c.515A>T 7:g.55152567A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LU-1516 2478818 2341580 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22510280 NS primary 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876614 2876614 2731129 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 133206440 c.2113G>C p.A705P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Confirmed somatic variant 29506987 circulating tumour NS 58 ENSP00000415559.1:p.Ala705Pro ENST00000455089.5:c.2113G>C 7:g.55174785G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876614 2876614 2731129 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 133213822 c.2018T>A p.L673Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Confirmed somatic variant 29506987 circulating tumour NS 58 ENSP00000415559.1:p.Leu673Gln ENST00000455089.5:c.2018T>A 7:g.55174012T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008601-T01-IM5 2724703 2583524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008601-T01-IM5 2724703 2583524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_C16 1863697 1754588 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007562-T01-IM5 2723848 2582669 soft_tissue fibrous_tissue_and_uncertain_origin NS NS malignant_fibrous_histiocytoma-pleomorphic_sarcoma NS NS NS n COSV51779875 COSM6958517 132598978 c.787G>A p.V263I Substitution - Missense het 38 7:55155862-55155862 + - PATHOGENIC .99324 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Val263Ile ENST00000454757.6:c.787G>A 7:g.55155862G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-C8-A1HG-01 1900020 1788704 breast NS NS NS carcinoma NS NS NS y COSV99290298 COSM7674140 132592921 c.2405C>A p.T802K Substitution - Missense 38 7:55191789-55191789 + - PATHOGENIC .95934 Confirmed somatic variant 414 fresh/frozen - NOS primary 50 ENSP00000395243.3:p.Thr802Lys ENST00000454757.6:c.2405C>A 7:g.55191789C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004208-T01-IM5 2720615 2579436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD9568a 1649032 1563971 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV51788518 COSM5752712 132571075 c.1651C>G p.P551A Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99615 Confirmed somatic variant 27135926 NS NS ENSP00000395243.3:p.Pro551Ala ENST00000454757.6:c.1651C>G 7:g.55165343C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-EE-A29S-06 2121645 1995881 skin NS NS NS malignant_melanoma NS NS NS y COSV51772666 COSM3412205 133207076 c.2812G>A p.G938R Substitution - Missense 38 7:55201188-55201188 + - PATHOGENIC .98883 Confirmed somatic variant 540 NS NS 79 ENSP00000415559.1:p.Gly938Arg ENST00000455089.5:c.2812G>A 7:g.55201188G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206768 1206768 1118646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0003967-T01-IM5 2720417 2579238 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008179-T01-IM5 2787021 2644444 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51799199 COSM1251020 132553945 c.1639G>A p.V547I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000395243.3:p.Val547Ile ENST00000454757.6:c.1639G>A 7:g.55165331G>A EGFR ENST00000275493.6 3633 3236 P-0008343-T01-IM5 2724471 2583292 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS n COSV51790148 COSM22555 99381470 c.2030G>A p.R677H Substitution - Missense het 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg677His ENST00000275493.6:c.2030G>A 7:g.55173093G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV51830890 COSM3639718 132579971 c.303G>T p.L101F Substitution - Missense 38 7:55143367-55143367 + - PATHOGENIC .93362 Confirmed somatic variant 540 NS NS 37 ENSP00000395243.3:p.Leu101Phe ENST00000454757.6:c.303G>T 7:g.55143367G>T EGFR ENST00000275493.6 3633 3236 2014_Lung_sq_14_T 2744885 2603588 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 58 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 TCGA-B7-A5TI-01 2457338 2320175 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99290867 COSM8197349 99407806 c.2758G>T p.A920S Substitution - Missense 38 7:55198773-55198773 + - PATHOGENIC .98826 Confirmed somatic variant 541 NS primary 52 ENSP00000275493.2:p.Ala920Ser ENST00000275493.6:c.2758G>T 7:g.55198773G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002689-T01-IM3 2718933 2577754 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51835394 COSM6923820 132598954 c.3019A>G p.R1007G Substitution - Missense het 38 7:55201774-55201774 + - .5653 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg1007Gly ENST00000454757.6:c.3019A>G 7:g.55201774A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011240-T01-IM5 2726852 2585673 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765999 COSM3266658 133233818 c.3071A>G p.Y1024C Substitution - Missense het 38 7:55202560-55202560 + - PATHOGENIC .97752 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Tyr1024Cys ENST00000455089.5:c.3071A>G 7:g.55202560A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876599 2876599 2731114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 132560202 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 59 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876599 2876599 2731114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 59 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S02347_1 2480908 2343653 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV51836148 COSM5694347 133222219 c.2543A>G p.H848R Substitution - Missense 38 7:55192818-55192818 + - PATHOGENIC .96101 Confirmed somatic variant 26168399 surgery fresh/frozen metastasis 67 ENSP00000415559.1:p.His848Arg ENST00000455089.5:c.2543A>G 7:g.55192818A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EXTERN_MELA_20140530_022 2839470 2695236 skin lip NS NS malignant_melanoma NS NS NS y COSV104577007 COSM9448763 133232346 c.1799C>T p.S600F Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99547 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000415559.1:p.Ser600Phe ENST00000455089.5:c.1799C>T 7:g.55172997C>T EGFR ENST00000275493.6 3633 3236 1122170 1122170 1035214 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51775222 COSM13189 99385712 c.2351C>T p.S784F Substitution - Missense het 38 7:55181360-55181360 + - PATHOGENIC .94833 Confirmed somatic variant 18379371 surgery - NOS primary 48 ENSP00000275493.2:p.Ser784Phe ENST00000275493.6:c.2351C>T 7:g.55181360C>T EGFR ENST00000275493.6 3633 3236 1122170 1122170 1035214 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51767182 COSM27110 99381953 c.2356G>A p.V786M Substitution - Missense het 38 7:55181365-55181365 + - PATHOGENIC .97319 Confirmed somatic variant 18379371 surgery - NOS primary 48 ENSP00000275493.2:p.Val786Met ENST00000275493.6:c.2356G>A 7:g.55181365G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811958 2811958 2668495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion metastasis 79 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010566-T01-IM5 2726268 2585089 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2812104 2812104 2668562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 31534501 pleural effusion NS 80 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2812104 2812104 2668562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 31534501 pleural effusion NS 80 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2696516 2696516 2555420 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28201779 surgery fresh/frozen NS 68 ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV99293881 COSM8150287 132579995 c.2811G>T p.Q937H Substitution - Missense 38 7:55200413-55200413 + - PATHOGENIC .99465 Confirmed somatic variant 540 NS NS 37 ENSP00000395243.3:p.Gln937His ENST00000454757.6:c.2811G>T 7:g.55200413G>T EGFR ENST00000275493.6 3633 3236 P-0009183-T01-IM5 2725158 2583979 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51786644 COSM6967269 99401622 c.3200A>T p.Q1067L Substitution - Missense het 38 7:55202554-55202554 + - PATHOGENIC .85028 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gln1067Leu ENST00000275493.6:c.3200A>T 7:g.55202554A>T EGFR ENST00000275493.6 3633 3236 P-0006758-T01-IM5 2723137 2581958 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51797815 COSM6953729 99412370 c.1867A>C p.N623H Substitution - Missense het 38 7:55165424-55165424 + - PATHOGENIC .99714 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Asn623His ENST00000275493.6:c.1867A>C 7:g.55165424A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-32-1979-01 2120345 1994581 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 133207083 c.674A>G p.Y225C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 329 NS NS 69 ENSP00000415559.1:p.Tyr225Cys ENST00000455089.5:c.674A>G 7:g.55154072A>G EGFR ENST00000275493.6 3633 3236 2591425 2591425 2452385 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2758916 2758916 2617466 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 23435014 surgery fresh/frozen NS 60.2 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2766020 2766020 2624254 breast NS NS NS carcinoma HER-positive_carcinoma NS NS n COSM255176 178385797 c.? p.A839T Substitution - Missense + - Confirmed somatic variant 30023006 surgery-fixed NS ENSP00000275493.2:p.Ala839Thr EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1109737 1109737 1023647 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 81 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152757 2152757 2021767 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51800786 COSM3734671 133241030 c.2128G>A p.A710T Substitution - Missense 38 7:55174800-55174800 + - PATHOGENIC .99476 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Ala710Thr ENST00000455089.5:c.2128G>A 7:g.55174800G>A EGFR ENST00000275493.6 3633 3236 2152700 2152700 2021710 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780783 COSM20817 99407048 c.2107C>G p.L703V Substitution - Missense 38 7:55173966-55173966 + - PATHOGENIC .96619 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu703Val ENST00000275493.6:c.2107C>G 7:g.55173966C>G EGFR ENST00000275493.6 3633 3236 2152700 2152700 2021710 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DCG_04 2664382 2524436 central_nervous_system cerebellum NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51838314 COSM6837033 133210824 c.1351G>A p.E451K Substitution - Missense 38 7:55160326-55160326 + - NEUTRAL .08736 Confirmed somatic variant 28852847 surgery fresh/frozen NS 40 ENSP00000415559.1:p.Glu451Lys ENST00000455089.5:c.1351G>A 7:g.55160326G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2865686 2865686 2720762 lung right_lower_lobe NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 27486332 surgery-fixed NS 50 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S001050 1027681 944657 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51835541 COSM21682 133247479 c.187G>C p.G63R Substitution - Missense het 38 7:55142384-55142384 + - PATHOGENIC .9897 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Gly63Arg ENST00000455089.5:c.187G>C 7:g.55142384G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S001050 1027681 944657 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51835525 COSM21681 133247472 c.136G>A p.D46N Substitution - Missense het 38 7:55142333-55142333 + - PATHOGENIC .94315 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Asp46Asn ENST00000455089.5:c.136G>A 7:g.55142333G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1502209 1502209 1425088 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51790305 COSM13194 133206846 c.2405C>T p.T802I Substitution - Missense het 38 7:55191789-55191789 + - PATHOGENIC .95119 Confirmed somatic variant 21457545 surgery-fixed NS ENSP00000415559.1:p.Thr802Ile ENST00000455089.5:c.2405C>T 7:g.55191789C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982859 982859 898578 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0008083-T01-IM5 2724269 2583090 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 99378223 c.2327G>A p.R776H Substitution - Missense het 38 7:55181336-55181336 + - PATHOGENIC .981 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000275493.2:p.Arg776His ENST00000275493.6:c.2327G>A 7:g.55181336G>A EGFR ENST00000275493.6 3633 3236 P-0008514-T01-IM5 2724609 2583430 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51780877 COSM26717 99375410 c.2579A>T p.K860I Substitution - Missense het 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Lys860Ile ENST00000275493.6:c.2579A>T 7:g.55191828A>T EGFR ENST00000275493.6 3633 3236 P-0008514-T01-IM5 2724609 2583430 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G NBPF3_ENST00000342104 ENST00000342104.9 1866 25076 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV59056369 COSM4166741 104047170 c.1235T>G p.F412C Substitution - Missense 38 1:21480113-21480113 + - NEUTRAL .00026 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000340336.5:p.Phe412Cys ENST00000342104.9:c.1235T>G 1:g.21480113T>G EGFR ENST00000275493.6 3633 3236 920042 920042 837121 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 15623594 surgery fresh/frozen NS 71 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 920042 920042 837121 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15623594 surgery fresh/frozen NS 71 ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T ZP1 ENST00000278853.9 1917 13187 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV53926873 COSM1322322 101161466 c.392C>T p.A131V Substitution - Missense 38 11:60869610-60869610 + - NEUTRAL .00098 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000278853.5:p.Ala131Val ENST00000278853.9:c.392C>T 11:g.60869610C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 16927 1423761 1333789 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2591471 2591471 2452431 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1211141 1211141 1123009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 60 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 16925 1423760 1333788 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 99378740 c.2582T>G p.L861R Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Arg ENST00000275493.6:c.2582T>G 7:g.55191831T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-VS057-T1 2869886 2724883 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105111245 COSM9804278 133203750 c.2840C>T p.P947L Substitution - Missense 38 7:55201216-55201216 + - PATHOGENIC .99346 Confirmed somatic variant 26950094 surgery - NOS NS 72 ENSP00000415559.1:p.Pro947Leu ENST00000455089.5:c.2840C>T 7:g.55201216C>T EGFR ENST00000275493.6 3633 3236 P-0010247-T01-IM5 2726036 2584857 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0010247-T01-IM5 2726036 2584857 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0006003-T01-IM5 2722386 2581207 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 P-0006003-T01-IM5 2722386 2581207 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 C086 2465276 2328109 NS NS NS NS malignant_melanoma NS NS NS y COSV51846033 COSM5530399 99400841 c.2756C>T p.P919L Substitution - Missense 38 7:55198771-55198771 + - PATHOGENIC .97363 Confirmed somatic variant 23890154 cell-line metastasis ENSP00000275493.2:p.Pro919Leu ENST00000275493.6:c.2756C>T 7:g.55198771C>T EGFR ENST00000275493.6 3633 3236 1486991 1486991 1410609 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51777202 COSM20896 99421874 c.2500G>A p.V834M Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 59 ENSP00000275493.2:p.Val834Met ENST00000275493.6:c.2500G>A 7:g.55191749G>A EGFR ENST00000275493.6 3633 3236 1486991 1486991 1410609 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51784752 COSM13199 99375727 c.2618G>A p.G873E Substitution - Missense 38 7:55191867-55191867 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 59 ENSP00000275493.2:p.Gly873Glu ENST00000275493.6:c.2618G>A 7:g.55191867G>A EGFR ENST00000275493.6 3633 3236 P-0011269-T01-IM5 2726879 2585700 skin NS NS NS malignant_melanoma NS NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 1841774 1841774 1735039 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM1166943 178385114 c.? p.V769L Substitution - Missense + - Confirmed somatic variant 23261230 surgery - NOS primary 42 ENSP00000275493.2:p.Val769Leu EGFR ENST00000275493.6 3633 3236 1841774 1841774 1735039 lung left_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Confirmed somatic variant 23261230 surgery - NOS primary 42 ENSP00000275493.2:p.Ser768Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-VS060-T1 2869889 2724886 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110495 COSM9804381 133280104 c.2636C>T p.S879F Substitution - Missense 38 7:55198786-55198786 + - PATHOGENIC .98269 Confirmed somatic variant 26950094 surgery - NOS NS 74 ENSP00000415559.1:p.Ser879Phe ENST00000455089.5:c.2636C>T 7:g.55198786C>T EGFR ENST00000275493.6 3633 3236 2152778 2152778 2021788 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2591355 2591355 2452315 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591355 2591355 2452315 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T3527 2296234 2161837 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51798634 COSM4680402 132560335 c.3304G>A p.V1102I Substitution - Missense 38 7:55205423-55205423 + - NEUTRAL .18974 Confirmed somatic variant 25344691 NS NS 73.91 ENSP00000395243.3:p.Val1102Ile ENST00000454757.6:c.3304G>A 7:g.55205423G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005929-T01-IM5 2722311 2581132 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 982865 982865 898584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152799 2152799 2021809 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0000900-T01-IM3 2716219 2575040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876612 2876612 2731127 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105110405 COSM9869915 133266042 c.2240T>G p.L747R Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .95324 Confirmed somatic variant 29506987 circulating tumour NS 73 ENSP00000415559.1:p.Leu747Arg ENST00000455089.5:c.2240T>G 7:g.55181384T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876612 2876612 2731127 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 73 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458678 1458678 1382653 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EE-A2MF-06 2339957 2204940 skin NS NS NS malignant_melanoma NS NS NS y COSV51776559 COSM4892884 132554171 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 540 NS NS 39 ENSP00000395243.3:p.Pro100Ser ENST00000454757.6:c.298C>T 7:g.55143362C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EE-A2MF-06 2339957 2204940 skin NS NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 132554177 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 540 NS NS 39 ENSP00000395243.3:p.Ser116Phe ENST00000454757.6:c.347C>T 7:g.55143411C>T EGFR ENST00000275493.6 3633 3236 S001103 1027689 944665 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 99378725 c.787A>C p.T263P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Thr263Pro ENST00000275493.6:c.787A>C 7:g.55154050A>C EGFR ENST00000275493.6 3633 3236 J11 2815385 2671765 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 29263181 surgery fresh/frozen NS 50 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 2115538 2115538 1989782 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 HCC41 2120840 1995076 liver NS NS NS carcinoma NS NS NS y COSV51780707 COSM1251019 99400219 c.3458G>T p.S1153I Substitution - Missense 38 7:55205442-55205442 + - NEUTRAL .36171 Confirmed somatic variant 323 NS NS ENSP00000275493.2:p.Ser1153Ile ENST00000275493.6:c.3458G>T 7:g.55205442G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812132 2812132 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV99289025 COSM9179905 133209408 c.2116A>G p.T706A Substitution - Missense 38 7:55174788-55174788 + - PATHOGENIC .9946 Confirmed somatic variant 31534501 pleural effusion NS 77 ENSP00000415559.1:p.Thr706Ala ENST00000455089.5:c.2116A>G 7:g.55174788A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812132 2812132 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51829458 COSM51497 133209395 c.2102_2103inv p.E701V Substitution - Missense 38 7:55174774-55174775 + - Confirmed somatic variant 31534501 pleural effusion NS 77 ENSP00000415559.1:p.Glu701Val ENST00000455089.5:c.2102_2103inv 7:g.55174774_55174775inv EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812132 2812132 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 pleural effusion NS 77 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 A103-T-S13 2757416 2616003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003030-T01-IM3 2719239 2578060 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914582 914582 832031 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51861444 COSM13007 132548215 c.2200_2201delinsTT p.G734F Substitution - Missense het 38 7:55181344-55181345 + - Confirmed somatic variant 15788655 surgery fresh/frozen primary 80 ENSP00000395243.3:p.Gly734Phe ENST00000454757.6:c.2200_2201delinsTT 7:g.55181344_55181345delinsTT EGFR ENST00000275493.6 3633 3236 PDA_074 2367415 2230253 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV51828052 COSM5002066 99442386 c.514T>C p.F172L Substitution - Missense 38 7:55146695-55146695 + - NEUTRAL .04786 Confirmed somatic variant 25855536 NS NS ENSP00000275493.2:p.Phe172Leu ENST00000275493.6:c.514T>C 7:g.55146695T>C EGFR ENST00000275493.6 3633 3236 LU-1516 2478818 2341580 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22510280 NS primary 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876614 2876614 2731129 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 99385331 c.2153T>A p.L718Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Confirmed somatic variant 29506987 circulating tumour NS 58 ENSP00000275493.2:p.Leu718Gln ENST00000275493.6:c.2153T>A 7:g.55174012T>A EGFR ENST00000275493.6 3633 3236 2876614 2876614 2731129 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 99378340 c.2248G>C p.A750P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Confirmed somatic variant 29506987 circulating tumour NS 58 ENSP00000275493.2:p.Ala750Pro ENST00000275493.6:c.2248G>C 7:g.55174785G>C EGFR ENST00000275493.6 3633 3236 P-0008601-T01-IM5 2724703 2583524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 P-0008601-T01-IM5 2724703 2583524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0004208-T01-IM5 2720615 2579436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CSCC-7-T 2292460 2158524 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51852113 COSM4501266 133219599 c.449C>T p.P150L Substitution - Missense het 38 7:55151318-55151318 + - NEUTRAL .31382 Confirmed somatic variant 25303977 surgery fresh/frozen primary 60 ENSP00000415559.1:p.Pro150Leu ENST00000455089.5:c.449C>T 7:g.55151318C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876598 2876598 2731113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 41 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-EE-A29S-06 2121645 1995881 skin NS NS NS malignant_melanoma NS NS NS y COSV51772666 COSM3412205 99378959 c.2947G>A p.G983R Substitution - Missense 38 7:55201188-55201188 + - PATHOGENIC .98883 Confirmed somatic variant 540 NS NS 79 ENSP00000275493.2:p.Gly983Arg ENST00000275493.6:c.2947G>A 7:g.55201188G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876598 2876598 2731113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 132563575 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 41 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2255G>C 7:g.55181399G>C EGFR ENST00000275493.6 3633 3236 DCG_04 2664382 2524436 central_nervous_system cerebellum NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51838314 COSM6837033 99382315 c.1486G>A p.E496K Substitution - Missense 38 7:55160326-55160326 + - NEUTRAL .08736 Confirmed somatic variant 28852847 surgery fresh/frozen NS 40 ENSP00000275493.2:p.Glu496Lys ENST00000275493.6:c.1486G>A 7:g.55160326G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006280-T01-IM5 2722658 2581479 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1052760 1052760 968831 soft_tissue fibrous_tissue_and_uncertain_origin NS NS malignant_fibrous_histiocytoma-pleomorphic_sarcoma storiform_pleomorphic NS NS n COSV51831473 COSM24671 132577979 c.1969G>A p.A657T Substitution - Missense 38 7:55173963-55173963 + - PATHOGENIC .97244 Confirmed somatic variant 17376509 surgery - NOS NS ENSP00000395243.3:p.Ala657Thr ENST00000454757.6:c.1969G>A 7:g.55173963G>A EGFR ENST00000275493.6 3633 3236 1206768 1206768 1118646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1472953 1472953 1396652 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51803731 COSM28604 132550372 c.2371C>T p.R791C Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .95213 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000395243.3:p.Arg791Cys ENST00000454757.6:c.2371C>T 7:g.55191755C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1472953 1472953 1396652 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51803719 COSM53291 132550364 c.2350G>A p.E784K Substitution - Missense 38 7:55191734-55191734 + - PATHOGENIC .98912 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000395243.3:p.Glu784Lys ENST00000454757.6:c.2350G>A 7:g.55191734G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1589267 1589267 1510421 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51823061 COSM133148 132604019 c.1993A>G p.T665A Substitution - Missense 38 7:55173987-55173987 + - PATHOGENIC .91254 Confirmed somatic variant 22026926 surgery fresh/frozen NS ENSP00000395243.3:p.Thr665Ala ENST00000454757.6:c.1993A>G 7:g.55173987A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009258-T01-IM5 2725216 2584037 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51838693 COSM6967815 132556832 c.2750G>A p.R917H Substitution - Missense het 38 7:55200352-55200352 + - PATHOGENIC .99038 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg917His ENST00000454757.6:c.2750G>A 7:g.55200352G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009258-T01-IM5 2725216 2584037 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51838710 COSM6967835 132556834 c.3271C>G p.P1091A Substitution - Missense het 38 7:55205390-55205390 + - PATHOGENIC .97767 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Pro1091Ala ENST00000454757.6:c.3271C>G 7:g.55205390C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002038-T01-IM3 2718344 2577165 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 133205309 c.2104_2105delinsCC p.L702P Substitution - Missense het 38 7:55174776-55174777 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu702Pro ENST00000455089.5:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010801-T01-IM5 2726469 2585290 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1472953 1472953 1396652 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51765351 COSM53292 132550377 c.2473C>T p.H825Y Substitution - Missense 38 7:55191857-55191857 + - PATHOGENIC .96355 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000395243.3:p.His825Tyr ENST00000454757.6:c.2473C>T 7:g.55191857C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-WS012-T14 2869947 2724944 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110458 COSM9657212 132598766 c.1316_1317delinsTT p.S439F Substitution - Missense 38 7:55160291-55160292 + - Confirmed somatic variant 26950094 surgery - NOS NS 82 ENSP00000395243.3:p.Ser439Phe ENST00000454757.6:c.1316_1317delinsTT 7:g.55160291_55160292delinsTT EGFR ENST00000275493.6 3633 3236 P-0011240-T01-IM5 2726852 2585673 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765999 COSM3266658 99407147 c.3206A>G p.Y1069C Substitution - Missense het 38 7:55202560-55202560 + - PATHOGENIC .97752 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Tyr1069Cys ENST00000275493.6:c.3206A>G 7:g.55202560A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010793-T01-IM5 2726461 2585282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010793-T01-IM5 2726461 2585282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006541-T02-IM5 2722917 2581738 NS NS NS NS malignant_melanoma NS NS NS n COSV51823220 COSM13179 132558313 c.1945C>T p.P649S Substitution - Missense het 38 7:55173939-55173939 + - PATHOGENIC .97389 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Pro649Ser ENST00000454757.6:c.1945C>T 7:g.55173939C>T EGFR ENST00000275493.6 3633 3236 S02347_1 2480908 2343653 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV51836148 COSM5694347 99396000 c.2678A>G p.H893R Substitution - Missense 38 7:55192818-55192818 + - PATHOGENIC .96101 Confirmed somatic variant 26168399 surgery fresh/frozen metastasis 67 ENSP00000275493.2:p.His893Arg ENST00000275493.6:c.2678A>G 7:g.55192818A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1472950 1472950 1396649 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51820767 COSM53288 133212022 c.2219C>T p.T740I Substitution - Missense 38 7:55181363-55181363 + - PATHOGENIC .9109 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000415559.1:p.Thr740Ile ENST00000455089.5:c.2219C>T 7:g.55181363C>T EGFR ENST00000275493.6 3633 3236 EXTERN_MELA_20140530_022 2839470 2695236 skin lip NS NS malignant_melanoma NS NS NS y COSV104577007 COSM9448763 99406139 c.1934C>T p.S645F Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99547 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000275493.2:p.Ser645Phe ENST00000275493.6:c.1934C>T 7:g.55172997C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005261-T01-IM5 2721660 2580481 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51861444 COSM13007 133203258 c.2200_2201delinsTT p.G734F Substitution - Missense het 38 7:55181344-55181345 + - Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Gly734Phe ENST00000455089.5:c.2200_2201delinsTT 7:g.55181344_55181345delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008179-T01-IM5 2830114 2685929 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 133209185 c.1639G>A p.V547I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000415559.1:p.Val547Ile ENST00000455089.5:c.1639G>A 7:g.55165331G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-0619-01 1909590 1798111 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 fresh/frozen - NOS primary 60 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 1010430 1010430 927604 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 17001163 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-32-1979-01 2120345 1994581 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 99378964 c.809A>G p.Y270C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 329 NS NS 69 ENSP00000275493.2:p.Tyr270Cys ENST00000275493.6:c.809A>G 7:g.55154072A>G EGFR ENST00000275493.6 3633 3236 2150417 2150417 2019486 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 57 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1109726 1109726 1023636 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152757 2152757 2021767 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51800786 COSM3734671 99415303 c.2263G>A p.A755T Substitution - Missense 38 7:55174800-55174800 + - PATHOGENIC .99476 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Ala755Thr ENST00000275493.6:c.2263G>A 7:g.55174800G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 B105-0 2097254 1975318 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV51776529 COSM1755314 133255255 c.1745G>A p.G582E Substitution - Missense 38 7:55165437-55165437 + - PATHOGENIC .99581 Confirmed somatic variant 24121792 fresh/frozen - NOS NS ENSP00000415559.1:p.Gly582Glu ENST00000455089.5:c.1745G>A 7:g.55165437G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812001 2812001 2668509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489260 1489260 1412418 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1502209 1502209 1425088 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51790305 COSM13194 99378747 c.2540C>T p.T847I Substitution - Missense het 38 7:55191789-55191789 + - PATHOGENIC .95119 Confirmed somatic variant 21457545 surgery-fixed NS ENSP00000275493.2:p.Thr847Ile ENST00000275493.6:c.2540C>T 7:g.55191789C>T EGFR ENST00000275493.6 3633 3236 982859 982859 898578 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G TRMT10B_ENST00000537911 ENST00000537911.5 771 26454 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105877142 COSM10012898 151183898 c.449G>C p.S150T Substitution - Missense 38 9:37769969-37769969 + - .6772 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000444997.1:p.Ser150Thr ENST00000537911.5:c.449G>C 9:g.37769969G>C EGFR ENST00000275493.6 3633 3236 2865686 2865686 2720762 lung right_lower_lobe NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 27486332 surgery-fixed NS 50 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 S001050 1027681 944657 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51835541 COSM21682 99423024 c.187G>C p.G63R Substitution - Missense het 38 7:55142384-55142384 + - PATHOGENIC .9897 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Gly63Arg ENST00000275493.6:c.187G>C 7:g.55142384G>C EGFR ENST00000275493.6 3633 3236 S001050 1027681 944657 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51835525 COSM21681 99423015 c.136G>A p.D46N Substitution - Missense het 38 7:55142333-55142333 + - PATHOGENIC .94315 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Asp46Asn ENST00000275493.6:c.136G>A 7:g.55142333G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PM01M 2653316 2513443 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS metastasis 48.07 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 16927 1423761 1333789 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000788-T01-IM3 2715990 2574811 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 5-VS057-T1 2869886 2724883 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105111245 COSM9804278 99375445 c.2975C>T p.P992L Substitution - Missense 38 7:55201216-55201216 + - PATHOGENIC .99346 Confirmed somatic variant 26950094 surgery - NOS NS 72 ENSP00000275493.2:p.Pro992Leu ENST00000275493.6:c.2975C>T 7:g.55201216C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811984 2811984 2668504 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed NS 57 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 56 898379 815991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471556 1471556 1395295 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CSCC-7-T 2292460 2158524 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51852113 COSM4501266 99392071 c.584C>T p.P195L Substitution - Missense het 38 7:55151318-55151318 + - NEUTRAL .31382 Confirmed somatic variant 25303977 surgery fresh/frozen primary 60 ENSP00000275493.2:p.Pro195Leu ENST00000275493.6:c.584C>T 7:g.55151318C>T EGFR ENST00000275493.6 3633 3236 5-VS060-T1 2869889 2724886 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110495 COSM9804381 99456012 c.2771C>T p.S924F Substitution - Missense 38 7:55198786-55198786 + - PATHOGENIC .98269 Confirmed somatic variant 26950094 surgery - NOS NS 74 ENSP00000275493.2:p.Ser924Phe ENST00000275493.6:c.2771C>T 7:g.55198786C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MB-T29 2802988 2659798 breast NS NS NS carcinoma ER-PR-positive_carcinoma NS NS n COSV51836185 COSM4884832 133234939 c.604G>T p.D202Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 26960396 fixed - NOS NS 83 ENSP00000415559.1:p.Asp202Tyr ENST00000455089.5:c.604G>T 7:g.55152656G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152779 2152779 2021789 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-14-1456-01 1338007 1248392 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 23 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P122 2072582 1951937 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 55.2 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001193-T01-IM3 2716798 2575619 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV51852240 COSM6915314 133207875 c.332T>C p.M111T Substitution - Missense het 38 7:55143396-55143396 + - PATHOGENIC .8651 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Met111Thr ENST00000455089.5:c.332T>C 7:g.55143396T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009824-T01-IM5 2725661 2584482 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004523-T01-IM5 2786950 2644373 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51780877 COSM26717 132548732 c.2444A>T p.K815I Substitution - Missense 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000395243.3:p.Lys815Ile ENST00000454757.6:c.2444A>T 7:g.55191828A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2492722 2492722 2355337 skin NS NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 133212507 c.2890G>A p.D964N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000415559.1:p.Asp964Asn ENST00000455089.5:c.2890G>A 7:g.55201266G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CTS47 2393061 2255892 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 59 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009311-T01-IM5 2725257 2584078 skin NS NS NS malignant_melanoma NS NS NS n COSV51862353 COSM6968107 133227125 c.2591C>T p.T864I Substitution - Missense het 38 7:55198741-55198741 + - PATHOGENIC .98954 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr864Ile ENST00000455089.5:c.2591C>T 7:g.55198741C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0014404-T01-IM6 2803908 2660658 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51806557 COSM6919399 132588470 c.2660G>A p.R887H Substitution - Missense het 38 7:55198810-55198810 + - PATHOGENIC .99081 Confirmed somatic variant 29316426 surgery-fixed primary 62 ENSP00000395243.3:p.Arg887His ENST00000454757.6:c.2660G>A 7:g.55198810G>A EGFR ENST00000275493.6 3633 3236 2876612 2876612 2731127 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105110405 COSM9869915 99442731 c.2375T>G p.L792R Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .95324 Confirmed somatic variant 29506987 circulating tumour NS 73 ENSP00000275493.2:p.Leu792Arg ENST00000275493.6:c.2375T>G 7:g.55181384T>G EGFR ENST00000275493.6 3633 3236 2876612 2876612 2731127 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 73 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003923-T01-IM5 2720399 2579220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51793896 COSM22954 133217512 c.2189G>A p.C730Y Substitution - Missense het 38 7:55181333-55181333 + - PATHOGENIC .97278 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Cys730Tyr ENST00000455089.5:c.2189G>A 7:g.55181333G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003923-T01-IM5 2720399 2579220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003923-T01-IM5 2720399 2579220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003923-T01-IM5 2720399 2579220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002218-T02-IM5 2719490 2578311 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2812132 2812132 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV99289025 COSM9179905 99381097 c.2251A>G p.T751A Substitution - Missense 38 7:55174788-55174788 + - PATHOGENIC .9946 Confirmed somatic variant 31534501 pleural effusion NS 77 ENSP00000275493.2:p.Thr751Ala ENST00000275493.6:c.2251A>G 7:g.55174788A>G EGFR ENST00000275493.6 3633 3236 2812132 2812132 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51829458 COSM51497 99381092 c.2237_2238inv p.E746V Substitution - Missense 38 7:55174774-55174775 + - Confirmed somatic variant 31534501 pleural effusion NS 77 ENSP00000275493.2:p.Glu746Val ENST00000275493.6:c.2237_2238inv 7:g.55174774_55174775inv EGFR ENST00000275493.6 3633 3236 2812132 2812132 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 pleural effusion NS 77 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1322278 1322278 1233165 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 59 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 RPMI-8226 1998470 1883542 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV51773111 COSM13185 133203473 c.2117C>T p.T706I Substitution - Missense het 38 7:55174789-55174789 + - PATHOGENIC .99151 Confirmed somatic variant 23856246 cell-line primary ENSP00000415559.1:p.Thr706Ile ENST00000455089.5:c.2117C>T 7:g.55174789C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008777-T01-IM5 2724826 2583647 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-92-6393-Tumor-SM-7CKB6 2640208 2500509 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma NS NS y COSV51802220 COSM6458155 133203867 c.805G>A p.D269N Substitution - Missense 38 7:55155880-55155880 + - PATHOGENIC .94623 Confirmed somatic variant 28098136 surgery-fixed primary 65 ENSP00000415559.1:p.Asp269Asn ENST00000455089.5:c.805G>A 7:g.55155880G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A103-T-S19 2757417 2616003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-13-0919-01 1475027 1398726 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51781063 COSM115794 133260518 c.2180C>G p.P727R Substitution - Missense het 38 7:55181324-55181324 + - PATHOGENIC .97777 Confirmed somatic variant 21720365 331 NS primary 52 ENSP00000415559.1:p.Pro727Arg ENST00000455089.5:c.2180C>G 7:g.55181324C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-27-1838-01 1338063 1248448 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 133205223 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000415559.1:p.Ala244Asp ENST00000455089.5:c.731C>A 7:g.55154129C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A103-T-S31 2757419 2616003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-VQ-A91D-01 2339968 2204951 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99289543 COSM8211280 99384227 c.3453C>A p.F1151L Substitution - Missense 38 7:55205437-55205437 + - NEUTRAL .20378 Confirmed somatic variant 541 NS primary 70 ENSP00000275493.2:p.Phe1151Leu ENST00000275493.6:c.3453C>A 7:g.55205437C>A EGFR ENST00000275493.6 3633 3236 P-0002038-T01-IM3 2718344 2577165 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 99377339 c.2239_2240delinsCC p.L747P Substitution - Missense het 38 7:55174776-55174777 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu747Pro ENST00000275493.6:c.2239_2240delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001257 1001257 918480 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1486988 1486988 1410606 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51816100 COSM13430 132569804 c.2380G>A p.A794T Substitution - Missense 38 7:55191764-55191764 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 63 ENSP00000395243.3:p.Ala794Thr ENST00000454757.6:c.2380G>A 7:g.55191764G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FP-A4BE-01 2197995 2066273 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51785413 COSM1176673 132555528 c.620G>A p.R207H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 541 NS NS 55 ENSP00000395243.3:p.Arg207His ENST00000454757.6:c.620G>A 7:g.55154018G>A EGFR ENST00000275493.6 3633 3236 P-0010793-T01-IM5 2726461 2585282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0010793-T01-IM5 2726461 2585282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1486988 1486988 1410606 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51782636 COSM85961 132548929 c.2383G>A p.A795T Substitution - Missense 38 7:55191767-55191767 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 63 ENSP00000395243.3:p.Ala795Thr ENST00000454757.6:c.2383G>A 7:g.55191767G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-0656 2108024 1985885 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 132550339 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Ala244Asp ENST00000454757.6:c.731C>A 7:g.55154129C>A EGFR ENST00000275493.6 3633 3236 P-0005261-T01-IM5 2721660 2580481 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51861444 COSM13007 99374834 c.2335_2336delinsTT p.G779F Substitution - Missense het 38 7:55181344-55181345 + - Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Gly779Phe ENST00000275493.6:c.2335_2336delinsTT 7:g.55181344_55181345delinsTT EGFR ENST00000275493.6 3633 3236 1472950 1472950 1396649 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51820767 COSM53288 99383393 c.2354C>T p.T785I Substitution - Missense 38 7:55181363-55181363 + - PATHOGENIC .9109 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000275493.2:p.Thr785Ile ENST00000275493.6:c.2354C>T 7:g.55181363C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-1804-01 2120260 1994496 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51855357 COSM3412180 133248498 c.631G>T p.D211Y Substitution - Missense 38 7:55154029-55154029 + - PATHOGENIC .9742 Confirmed somatic variant 329 NS NS 81 ENSP00000415559.1:p.Asp211Tyr ENST00000455089.5:c.631G>T 7:g.55154029G>T EGFR ENST00000275493.6 3633 3236 P-0008179-T01-IM5 2830114 2685929 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 99380942 c.1774G>A p.V592I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000275493.2:p.Val592Ile ENST00000275493.6:c.1774G>A 7:g.55165331G>A EGFR ENST00000275493.6 3633 3236 1880595 1880595 1770989 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23403410 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-12-0619-01 1909590 1798111 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 fresh/frozen - NOS primary 60 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089890 1089890 1004837 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17784875 surgery-fixed primary 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 600 2131840 2005904 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51777649 COSM3721610 132587165 c.473G>A p.G158E Substitution - Missense 38 7:55151342-55151342 + - PATHOGENIC .98938 Confirmed somatic variant 23619168 fresh/frozen - NOS NS 57 ENSP00000395243.3:p.Gly158Glu ENST00000454757.6:c.473G>A 7:g.55151342G>A EGFR ENST00000275493.6 3633 3236 1109726 1109726 1023636 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006915-T01-IM5 2723295 2582116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006915-T01-IM5 2723295 2582116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 B105-0 2097254 1975318 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV51776529 COSM1755314 99431721 c.1880G>A p.G627E Substitution - Missense 38 7:55165437-55165437 + - PATHOGENIC .99581 Confirmed somatic variant 24121792 fresh/frozen - NOS NS ENSP00000275493.2:p.Gly627Glu ENST00000275493.6:c.1880G>A 7:g.55165437G>A EGFR ENST00000275493.6 3633 3236 2812001 2812001 2668509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489260 1489260 1412418 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876664 2876664 2731179 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 37 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005985-T01-IM5 2722368 2581189 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 460 898390 816002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 PM01M 2653316 2513443 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS metastasis 48.07 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-76-6661-01 2120394 1994630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 132551380 c.775C>T p.H259Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 NS NS 54 ENSP00000395243.3:p.His259Tyr ENST00000454757.6:c.775C>T 7:g.55155850C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-76-6661-01 2120394 1994630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51814881 COSM3929116 132567904 c.799G>T p.G267W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 329 NS NS 54 ENSP00000395243.3:p.Gly267Trp ENST00000454757.6:c.799G>T 7:g.55155874G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2905703 2905703 2759959 lung left_upper_lobe NS NS other bronchiolar_adenoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 33400370 surgery-fixed NS 76 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2905703 2905703 2759959 lung left_upper_lobe NS NS other bronchiolar_adenoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 33400370 surgery-fixed NS 76 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876617 2876617 2731132 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + Yes PATHOGENIC .98253 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2492722 2492722 2355337 skin NS NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 99383908 c.3025G>A p.D1009N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000275493.2:p.Asp1009Asn ENST00000275493.6:c.3025G>A 7:g.55201266G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-D1-A103-01 1783494 1687493 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99294091 COSM9081690 132561751 c.1853G>T p.G618V Substitution - Missense 38 7:55173051-55173051 + - PATHOGENIC .792 Confirmed somatic variant 419 fresh/frozen - NOS primary 87 ENSP00000395243.3:p.Gly618Val ENST00000454757.6:c.1853G>T 7:g.55173051G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Br247T 1313059 1223968 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827490 COSM39163 132566663 c.1772G>A p.C591Y Substitution - Missense het 38 7:55171201-55171201 + - PATHOGENIC .98251 Confirmed somatic variant 18772396 surgery - NOS primary 39 ENSP00000395243.3:p.Cys591Tyr ENST00000454757.6:c.1772G>A 7:g.55171201G>A EGFR ENST00000275493.6 3633 3236 P-0000788-T01-IM3 2715990 2574811 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-14-0790-01 1337989 1248374 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 64 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SJDES007-R1 2294507 2160534 bone scapula NS NS Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour NS NS NS y COSV51785438 COSM3366978 132583357 c.2360G>A p.R787H Substitution - Missense 38 7:55191744-55191744 + - PATHOGENIC .9403 Confirmed somatic variant 25186949 NS primary 17 ENSP00000395243.3:p.Arg787His ENST00000454757.6:c.2360G>A 7:g.55191744G>A EGFR ENST00000275493.6 3633 3236 2042518 2042518 1923636 lung NS NS NS other dysplasia-carcinoma_in_situ NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Confirmed somatic variant 23688269 surgery fresh/frozen primary 73 ENSP00000275493.2:p.Leu861Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004813 1004813 922025 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16140420 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002965-T01-IM3 2719174 2577995 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51819502 COSM6925302 132596754 c.3010T>C p.C1004R Substitution - Missense het 38 7:55201765-55201765 + - PATHOGENIC .9732 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Cys1004Arg ENST00000454757.6:c.3010T>C 7:g.55201765T>C EGFR ENST00000275493.6 3633 3236 56 898379 815991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-CH-5765-01 1797170 1698917 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51795500 COSM1131544 132584209 c.557G>C p.C186S Substitution - Missense 38 7:55152609-55152609 + - PATHOGENIC .99547 Confirmed somatic variant 435 fresh/frozen - NOS primary 55 ENSP00000395243.3:p.Cys186Ser ENST00000454757.6:c.557G>C 7:g.55152609G>C EGFR ENST00000275493.6 3633 3236 2811984 2811984 2668504 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed NS 57 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007864-T01-IM5 2724078 2582899 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 IGC-04-1136 2662303 2522427 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51809481 COSM6530127 132562717 c.856G>C p.G286R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .97571 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000395243.3:p.Gly286Arg ENST00000454757.6:c.856G>C 7:g.55155931G>C EGFR ENST00000275493.6 3633 3236 MB-T29 2802988 2659798 breast NS NS NS carcinoma ER-PR-positive_carcinoma NS NS n COSV51836185 COSM4884832 99407985 c.739G>T p.D247Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 26960396 fixed - NOS NS 83 ENSP00000275493.2:p.Asp247Tyr ENST00000275493.6:c.739G>T 7:g.55152656G>T EGFR ENST00000275493.6 3633 3236 TCGA-14-1456-01 1338007 1248392 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 23 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 P-0001193-T01-IM3 2716798 2575619 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV51852240 COSM6915314 99379699 c.332T>C p.M111T Substitution - Missense het 38 7:55143396-55143396 + - PATHOGENIC .8651 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Met111Thr ENST00000275493.6:c.332T>C 7:g.55143396T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CH-LA5 2211431 2079634 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24449147 surgery fresh/frozen NS 59 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001226 1001226 918449 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51780783 COSM20817 133233676 c.1972C>G p.L658V Substitution - Missense 38 7:55173966-55173966 + - PATHOGENIC .96619 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu658Val ENST00000455089.5:c.1972C>G 7:g.55173966C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DCG_17 2664395 2524449 central_nervous_system cerebellum NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779794 COSM53264 132559797 c.2039C>T p.T680M Substitution - Missense 38 7:55174033-55174033 + - PATHOGENIC .97744 Confirmed somatic variant 28852847 surgery fresh/frozen NS 77 ENSP00000395243.3:p.Thr680Met ENST00000454757.6:c.2039C>T 7:g.55174033C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-ER-A42L-06 2456271 2319108 skin NS NS NS malignant_melanoma NS NS NS y COSV99287971 COSM7900658 132575956 c.1646C>T p.T549I Substitution - Missense 38 7:55165338-55165338 + - PATHOGENIC .94394 Confirmed somatic variant 540 NS metastasis 49 ENSP00000395243.3:p.Thr549Ile ENST00000454757.6:c.1646C>T 7:g.55165338C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 C1409280774 2861656 2716876 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 27247954 pleural effusion NS 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 C1409280774 2861656 2716876 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 27247954 pleural effusion NS 67 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0009311-T01-IM5 2725257 2584078 skin NS NS NS malignant_melanoma NS NS NS n COSV51862353 COSM6968107 99401626 c.2726C>T p.T909I Substitution - Missense het 38 7:55198741-55198741 + - PATHOGENIC .98954 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr909Ile ENST00000275493.6:c.2726C>T 7:g.55198741C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000894-T01-IM3 2716206 2575027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51822498 COSM3266565 132578509 c.782C>T p.S261L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ser261Leu ENST00000454757.6:c.782C>T 7:g.55155857C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000894-T01-IM3 2716206 2575027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777111 COSM33725 132559461 c.2474A>G p.H825R Substitution - Missense het 38 7:55191858-55191858 + - PATHOGENIC .97748 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.His825Arg ENST00000454757.6:c.2474A>G 7:g.55191858A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000894-T01-IM3 2716206 2575027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876615 2876615 2731130 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 132557758 c.2018T>A p.L673Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Confirmed somatic variant 29506987 circulating tumour NS 53 ENSP00000395243.3:p.Leu673Gln ENST00000454757.6:c.2018T>A 7:g.55174012T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876615 2876615 2731130 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 53 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-0691 2108027 1985888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774829 COSM1451549 132549970 c.632A>G p.D211G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Asp211Gly ENST00000454757.6:c.632A>G 7:g.55154030A>G EGFR ENST00000275493.6 3633 3236 P-0003923-T01-IM5 2720399 2579220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 P-0003923-T01-IM5 2720399 2579220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 P-0003923-T01-IM5 2720399 2579220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51793896 COSM22954 99389719 c.2324G>A p.C775Y Substitution - Missense het 38 7:55181333-55181333 + - PATHOGENIC .97278 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Cys775Tyr ENST00000275493.6:c.2324G>A 7:g.55181333G>A EGFR ENST00000275493.6 3633 3236 P-0003923-T01-IM5 2720399 2579220 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1322278 1322278 1233165 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 59 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876653 2876653 2731168 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005009 1005009 922221 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152765 2152765 2021775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 RPMI-8226 1998470 1883542 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV51773111 COSM13185 99375118 c.2252C>T p.T751I Substitution - Missense het 38 7:55174789-55174789 + - PATHOGENIC .99151 Confirmed somatic variant 23856246 cell-line primary ENSP00000275493.2:p.Thr751Ile ENST00000275493.6:c.2252C>T 7:g.55174789C>T EGFR ENST00000275493.6 3633 3236 P-0008777-T01-IM5 2724826 2583647 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006622-T01-IM5 2786996 2644419 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51845994 COSM5530405 132547619 c.1498G>A p.E500K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000395243.3:p.Glu500Lys ENST00000454757.6:c.1498G>A 7:g.55163734G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194733 1194733 1106628 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 16760 1423719 1333747 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-92-6393-Tumor-SM-7CKB6 2640208 2500509 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma NS NS y COSV51802220 COSM6458155 99375567 c.940G>A p.D314N Substitution - Missense 38 7:55155880-55155880 + - PATHOGENIC .94623 Confirmed somatic variant 28098136 surgery-fixed primary 65 ENSP00000275493.2:p.Asp314Asn ENST00000275493.6:c.940G>A 7:g.55155880G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876628 2876628 2731143 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 surgery fresh/frozen NS 52 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-13-0919-01 1475027 1398726 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51781063 COSM115794 99437616 c.2315C>G p.P772R Substitution - Missense het 38 7:55181324-55181324 + - PATHOGENIC .97777 Confirmed somatic variant 21720365 331 NS primary 52 ENSP00000275493.2:p.Pro772Arg ENST00000275493.6:c.2315C>G 7:g.55181324C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-VQ-A8PX-01 2339506 2204489 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99285314 COSM8202780 133233826 c.536G>A p.R179H Substitution - Missense 38 7:55152588-55152588 + - PATHOGENIC .91275 Confirmed somatic variant 541 NS primary 51 ENSP00000415559.1:p.Arg179His ENST00000455089.5:c.536G>A 7:g.55152588G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Thyroid-CN-WZ037T 2635098 2495494 thyroid NS NS NS carcinoma NS NS NS y COSV51794993 COSM6399094 132564700 c.5G>A p.R2Q Substitution - Missense 38 7:55019282-55019282 + - NEUTRAL .46409 Confirmed somatic variant 676 NS primary 40 ENSP00000395243.3:p.Arg2Gln ENST00000454757.6:c.5G>A 7:g.55019282G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SDC7 2564876 2426270 salivary_gland NS NS NS carcinoma salivary_duct_carcinoma NS NS y COSV51792147 COSM5988249 132572784 c.1035G>T p.Q345H Substitution - Missense 38 7:55156795-55156795 + - NEUTRAL .3446 Confirmed somatic variant 27103403 surgery fresh/frozen recurrent ENSP00000395243.3:p.Gln345His ENST00000454757.6:c.1035G>T 7:g.55156795G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1044288 1044288 960629 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-27-1838-01 1338063 1248448 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 99377226 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000275493.2:p.Ala289Asp ENST00000275493.6:c.866C>A 7:g.55154129C>A EGFR ENST00000275493.6 3633 3236 A103-T-S19 2757417 2616003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010995-T01-IM5 2726638 2585459 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51806727 COSM6978402 133215997 c.2183_2185delinsTCA p.H728_V729delinsLM Substitution - Missense het 38 7:55181327-55181329 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.His728_Val729delinsLeuMet ENST00000455089.5:c.2183_2185delinsTCA 7:g.55181327_55181329delinsTCA EGFR_ENST00000455089 ENST00000455089.5 3276 3236 XHDG51C 2321278 2186432 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS n COSV51818388 COSM53104 133232583 c.2255G>A p.C752Y Substitution - Missense 38 7:55181399-55181399 + - PATHOGENIC .98244 Confirmed somatic variant 24997986 NS NS 56 ENSP00000415559.1:p.Cys752Tyr ENST00000455089.5:c.2255G>A 7:g.55181399G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-13-0900-01 1474861 1398560 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51795875 COSM116882 132560959 c.1990G>C p.E664Q Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98409 Confirmed somatic variant 21720365 331 NS primary 59 ENSP00000395243.3:p.Glu664Gln ENST00000454757.6:c.1990G>C 7:g.55173984G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BC79-tumour 2668206 2527786 breast NS NS NS carcinoma NS NS NS y COSV51792227 COSM6582372 133209733 c.2524T>A p.L842I Substitution - Missense het 38 7:55192799-55192799 + - PATHOGENIC .84827 Confirmed somatic variant 27535334 surgery fresh/frozen metastasis ENSP00000415559.1:p.Leu842Ile ENST00000455089.5:c.2524T>A 7:g.55192799T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV51830890 COSM3639718 133240904 c.303G>T p.L101F Substitution - Missense 38 7:55143367-55143367 + - PATHOGENIC .93362 Confirmed somatic variant 540 NS NS 37 ENSP00000415559.1:p.Leu101Phe ENST00000455089.5:c.303G>T 7:g.55143367G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 I2L-P7-Tumor-Organoid 2433490 2296371 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51828974 COSM5358463 132573711 c.3253A>C p.S1085R Substitution - Missense het 38 7:55205372-55205372 + - PATHOGENIC .96828 Confirmed somatic variant 25957691 NS NS 81 ENSP00000395243.3:p.Ser1085Arg ENST00000454757.6:c.3253A>C 7:g.55205372A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV99293881 COSM8150287 133240935 c.2811G>T p.Q937H Substitution - Missense 38 7:55200413-55200413 + - PATHOGENIC .99465 Confirmed somatic variant 540 NS NS 37 ENSP00000415559.1:p.Gln937His ENST00000455089.5:c.2811G>T 7:g.55200413G>T EGFR ENST00000275493.6 3633 3236 1468643 1468643 1392394 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1001257 1001257 918480 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876065 2876065 2730580 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GYWU_831 2771306 2629499 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV99290440 COSM7410173 132582578 c.3038G>A p.C1013Y Substitution - Missense 38 7:55202527-55202527 + - NEUTRAL .29295 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000395243.3:p.Cys1013Tyr ENST00000454757.6:c.3038G>A 7:g.55202527G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-1804-01 2120260 1994496 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51855357 COSM3412180 99424228 c.766G>T p.D256Y Substitution - Missense 38 7:55154029-55154029 + - PATHOGENIC .9742 Confirmed somatic variant 329 NS NS 81 ENSP00000275493.2:p.Asp256Tyr ENST00000275493.6:c.766G>T 7:g.55154029G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 IGC-02-1183 2662280 2522404 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51792209 COSM6548316 132558030 c.2069G>T p.G690V Substitution - Missense 38 7:55174741-55174741 + - PATHOGENIC .99891 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000395243.3:p.Gly690Val ENST00000454757.6:c.2069G>T 7:g.55174741G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002446-T01-IM3 2718721 2577542 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001124-T01-IM3 2716673 2575494 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51781531 COSM6914964 133223795 c.515A>T p.Q172L Substitution - Missense het 38 7:55152567-55152567 + - PATHOGENIC .9889 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gln172Leu ENST00000455089.5:c.515A>T 7:g.55152567A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Br20P 1312980 1223889 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51815967 COSM39522 132550299 c.520T>G p.C174G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 18772396 surgery - NOS primary 77 ENSP00000395243.3:p.Cys174Gly ENST00000454757.6:c.520T>G 7:g.55152572T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920036 920036 837115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_C16 1863697 1754588 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007562-T01-IM5 2723848 2582669 soft_tissue fibrous_tissue_and_uncertain_origin NS NS malignant_fibrous_histiocytoma-pleomorphic_sarcoma NS NS NS n COSV51779875 COSM6958517 133262839 c.787G>A p.V263I Substitution - Missense het 38 7:55155862-55155862 + - PATHOGENIC .99324 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Val263Ile ENST00000455089.5:c.787G>A 7:g.55155862G>A OR7C1_ENST00000642000 ENST00000642000.1 963 8373 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV50183885 COSM1390989 176048783 c.364C>T p.R122C Substitution - Missense 38 19:14799773-14799773 - - .5891 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000493248.1:p.Arg122Cys ENST00000642000.1:c.364C>T 19:g.14799773G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-C8-A1HG-01 1900020 1788704 breast NS NS NS carcinoma NS NS NS y COSV99290298 COSM7674140 133255770 c.2405C>A p.T802K Substitution - Missense 38 7:55191789-55191789 + - PATHOGENIC .95934 Confirmed somatic variant 414 fresh/frozen - NOS primary 50 ENSP00000415559.1:p.Thr802Lys ENST00000455089.5:c.2405C>A 7:g.55191789C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD9568a 1649032 1563971 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV51788518 COSM5752712 133228816 c.1651C>G p.P551A Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99615 Confirmed somatic variant 27135926 NS NS ENSP00000415559.1:p.Pro551Ala ENST00000455089.5:c.1651C>G 7:g.55165343C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BS-A0UF-01 1783473 1687472 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51780766 COSM219795 132546924 c.2456C>T p.A819V Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .93098 Confirmed somatic variant 419 fresh/frozen - NOS primary 65 ENSP00000395243.3:p.Ala819Val ENST00000454757.6:c.2456C>T 7:g.55191840C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009587-T01-IM5 2725481 2584302 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009587-T01-IM5 2725481 2584302 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 2876664 2876664 2731179 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 37 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0005985-T01-IM5 2722368 2581189 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV99293869 COSM8151148 133240913 c.973C>A p.H325N Substitution - Missense 38 7:55156634-55156634 + - NEUTRAL .19929 Confirmed somatic variant 540 NS NS 37 ENSP00000415559.1:p.His325Asn ENST00000455089.5:c.973C>A 7:g.55156634C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008179-T01-IM5 2787021 2644444 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51799199 COSM1251020 133209185 c.1639G>A p.V547I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000415559.1:p.Val547Ile ENST00000455089.5:c.1639G>A 7:g.55165331G>A EGFR ENST00000275493.6 3633 3236 TCGA-14-0790-01 1337989 1248374 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 64 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005254 1005254 922466 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51770694 COSM20891 132562677 c.2251G>A p.G751S Substitution - Missense 38 7:55181395-55181395 + - PATHOGENIC .98244 Confirmed somatic variant 16720329 surgery-fixed primary 67 ENSP00000395243.3:p.Gly751Ser ENST00000454757.6:c.2251G>A 7:g.55181395G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211133 1211133 1123001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen metastasis 67 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002689-T01-IM3 2718933 2577754 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51835394 COSM6923820 133262812 c.3019A>G p.R1007G Substitution - Missense het 38 7:55201774-55201774 + - .5653 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg1007Gly ENST00000455089.5:c.3019A>G 7:g.55201774A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876599 2876599 2731114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 133216269 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 59 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2254T>A 7:g.55181398T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876599 2876599 2731114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 59 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 ESCC_BICR_010T 2456865 2319702 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51822386 COSM5436048 132596127 c.1439C>G p.S480C Substitution - Missense 38 7:55161574-55161574 + - PATHOGENIC .96861 Confirmed somatic variant 582 NS primary 70 ENSP00000395243.3:p.Ser480Cys ENST00000454757.6:c.1439C>G 7:g.55161574C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811958 2811958 2668495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion metastasis 79 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920033 920033 837112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765252 COSM13009 132568674 c.1991A>G p.E664G Substitution - Missense hom 38 7:55173985-55173985 + - PATHOGENIC .97508 Confirmed somatic variant 15623594 surgery fresh/frozen NS 50 ENSP00000395243.3:p.Glu664Gly ENST00000454757.6:c.1991A>G 7:g.55173985A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920033 920033 837112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 50 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010566-T01-IM5 2726268 2585089 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2696516 2696516 2555420 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28201779 surgery fresh/frozen NS 68 ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 1001226 1001226 918449 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51780783 COSM20817 99407048 c.2107C>G p.L703V Substitution - Missense 38 7:55173966-55173966 + - PATHOGENIC .96619 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu703Val ENST00000275493.6:c.2107C>G 7:g.55173966C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EX01M 2653306 2513433 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS metastasis 58.5 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A065-T-S09 2757402 2616000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 C1409280774 2861656 2716876 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 27247954 pleural effusion NS 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 C1409280774 2861656 2716876 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 27247954 pleural effusion NS 67 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811951 2811951 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 31534501 surgery-fixed NS 69 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811951 2811951 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 132551897 c.2447T>G p.L816R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 31534501 surgery-fixed NS 69 ENSP00000395243.3:p.Leu816Arg ENST00000454757.6:c.2447T>G 7:g.55191831T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1109737 1109737 1023647 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 81 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876054 2876054 2730569 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 44 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876653 2876653 2731168 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011149-T01-IM5 2726775 2585596 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51770500 COSM6979164 132589370 c.2225A>T p.Q742L Substitution - Missense het 38 7:55181369-55181369 + - PATHOGENIC .97936 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Gln742Leu ENST00000454757.6:c.2225A>T 7:g.55181369A>T EGFR ENST00000275493.6 3633 3236 1005009 1005009 922221 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2862410 2862410 2717594 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM9583351 178378279 c.? p.N842K Substitution - Missense + - Confirmed somatic variant 31694833 circulating tumour primary 58 EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982870 982870 898589 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CRC104post 2730749 2589518 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV104577027 COSM9413135 132564218 c.1259G>A p.G420E Substitution - Missense 38 7:55160234-55160234 + - NEUTRAL .11765 Confirmed somatic variant 26416732 xenograft metastasis 62 ENSP00000395243.3:p.Gly420Glu ENST00000454757.6:c.1259G>A 7:g.55160234G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0743-01 1337857 1248242 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 69 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002647-T01-IM3 2718893 2577714 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 TCGA-VQ-A8PX-01 2339506 2204489 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99285314 COSM8202780 99407160 c.671G>A p.R224H Substitution - Missense 38 7:55152588-55152588 + - PATHOGENIC .91275 Confirmed somatic variant 541 NS primary 51 ENSP00000275493.2:p.Arg224His ENST00000275493.6:c.671G>A 7:g.55152588G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0881-01 1337868 1248253 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2876628 2876628 2731143 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 surgery fresh/frozen NS 52 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2591371 2591371 2452331 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591371 2591371 2452331 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0010995-T01-IM5 2726638 2585459 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51806727 COSM6978402 99387873 c.2318_2320delinsTCA p.H773_V774delinsLM Substitution - Missense het 38 7:55181327-55181329 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.His773_Val774delinsLeuMet ENST00000275493.6:c.2318_2320delinsTCA 7:g.55181327_55181329delinsTCA EGFR ENST00000275493.6 3633 3236 P-0000944-T01-IM3 2716313 2575134 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51841863 COSM6913649 99377584 c.3415C>T p.L1139F Substitution - Missense het 38 7:55205399-55205399 + - PATHOGENIC .96614 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu1139Phe ENST00000275493.6:c.3415C>T 7:g.55205399C>T EGFR ENST00000275493.6 3633 3236 BC79-tumour 2668206 2527786 breast NS NS NS carcinoma NS NS NS y COSV51792227 COSM6582372 99381421 c.2659T>A p.L887I Substitution - Missense het 38 7:55192799-55192799 + - PATHOGENIC .84827 Confirmed somatic variant 27535334 surgery fresh/frozen metastasis ENSP00000275493.2:p.Leu887Ile ENST00000275493.6:c.2659T>A 7:g.55192799T>A EGFR ENST00000275493.6 3633 3236 XHDG51C 2321278 2186432 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS n COSV51818388 COSM53104 99406297 c.2390G>A p.C797Y Substitution - Missense 38 7:55181399-55181399 + - PATHOGENIC .98244 Confirmed somatic variant 24997986 NS NS 56 ENSP00000275493.2:p.Cys797Tyr ENST00000275493.6:c.2390G>A 7:g.55181399G>A EGFR ENST00000275493.6 3633 3236 1010440 1010440 927614 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 17001163 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A114-T-S59 2757429 2616005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 61 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1790524 1790524 1693503 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-14-1395-01 2120295 1994531 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51827895 COSM3412174 132552248 c.550A>T p.S184C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 329 NS NS 52 ENSP00000395243.3:p.Ser184Cys ENST00000454757.6:c.550A>T 7:g.55152602A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-B6-A0RQ-01 1899865 1788549 breast NS NS NS carcinoma NS NS NS y COSV51832348 COSM6974705 132584044 c.3467C>T p.A1156V Substitution - Missense 38 7:55205586-55205586 + - PATHOGENIC .8173 Confirmed somatic variant 414 fresh/frozen - NOS primary 68 ENSP00000395243.3:p.Ala1156Val ENST00000454757.6:c.3467C>T 7:g.55205586C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A062-T-S23 2757399 2615999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1044289 1044289 960630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 16965 1423769 1333797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 16965 1423769 1333797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51774819 COSM35840 132552089 c.1816G>A p.V606M Substitution - Missense het 38 7:55173014-55173014 + - PATHOGENIC .99458 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Val606Met ENST00000454757.6:c.1816G>A 7:g.55173014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004729-T01-IM5 2721133 2579954 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV99293881 COSM8150287 99415177 c.2946G>T p.Q982H Substitution - Missense 38 7:55200413-55200413 + - PATHOGENIC .99465 Confirmed somatic variant 540 NS NS 37 ENSP00000275493.2:p.Gln982His ENST00000275493.6:c.2946G>T 7:g.55200413G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876622 2876622 2731137 lung NS NS NS carcinoma NS NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 29506987 circulating tumour NS 51 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876622 2876622 2731137 lung NS NS NS carcinoma NS NS NS n COSV51785510 COSM6957413 132547201 c.967G>A p.D323N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 29506987 circulating tumour NS 51 ENSP00000395243.3:p.Asp323Asn ENST00000454757.6:c.967G>A 7:g.55156628G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876622 2876622 2731137 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 51 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001123-T01-IM3 2716671 2575492 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T2935 2658562 2518721 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51820069 COSM6652271 132556093 c.1796C>T p.P599L Substitution - Missense 38 7:55172994-55172994 + - PATHOGENIC .98245 Confirmed somatic variant 27149842 NS NS 64.16 ENSP00000395243.3:p.Pro599Leu ENST00000454757.6:c.1796C>T 7:g.55172994C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876657 2876657 2731172 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2591383 2591383 2452343 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591383 2591383 2452343 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005929-T01-IM5 2722311 2581132 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 P-0001124-T01-IM3 2716673 2575494 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51781531 COSM6914964 99398341 c.650A>T p.Q217L Substitution - Missense het 38 7:55152567-55152567 + - PATHOGENIC .9889 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gln217Leu ENST00000275493.6:c.650A>T 7:g.55152567A>T EGFR ENST00000275493.6 3633 3236 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV51830890 COSM3639718 99415137 c.303G>T p.L101F Substitution - Missense 38 7:55143367-55143367 + - PATHOGENIC .93362 Confirmed somatic variant 540 NS NS 37 ENSP00000275493.2:p.Leu101Phe ENST00000275493.6:c.303G>T 7:g.55143367G>T EGFR ENST00000275493.6 3633 3236 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV99293869 COSM8151148 99415149 c.1108C>A p.H370N Substitution - Missense 38 7:55156634-55156634 + - NEUTRAL .19929 Confirmed somatic variant 540 NS NS 37 ENSP00000275493.2:p.His370Asn ENST00000275493.6:c.1108C>A 7:g.55156634C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152799 2152799 2021809 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458678 1458678 1382653 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LC_C16 1863697 1754588 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0007562-T01-IM5 2723848 2582669 soft_tissue fibrous_tissue_and_uncertain_origin NS NS malignant_fibrous_histiocytoma-pleomorphic_sarcoma NS NS NS n COSV51779875 COSM6958517 99439746 c.922G>A p.V308I Substitution - Missense het 38 7:55155862-55155862 + - PATHOGENIC .99324 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Val308Ile ENST00000275493.6:c.922G>A 7:g.55155862G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-EE-A2MF-06 2339957 2204940 skin NS NS NS malignant_melanoma NS NS NS y COSV51776559 COSM4892884 133209480 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 540 NS NS 39 ENSP00000415559.1:p.Pro100Ser ENST00000455089.5:c.298C>T 7:g.55143362C>T EGFR ENST00000275493.6 3633 3236 TCGA-C8-A1HG-01 1900020 1788704 breast NS NS NS carcinoma NS NS NS y COSV99290298 COSM7674140 99432283 c.2540C>A p.T847K Substitution - Missense 38 7:55191789-55191789 + - PATHOGENIC .95934 Confirmed somatic variant 414 fresh/frozen - NOS primary 50 ENSP00000275493.2:p.Thr847Lys ENST00000275493.6:c.2540C>A 7:g.55191789C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-EE-A2MF-06 2339957 2204940 skin NS NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 133209492 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 540 NS NS 39 ENSP00000415559.1:p.Ser116Phe ENST00000455089.5:c.347C>T 7:g.55143411C>T EGFR ENST00000275493.6 3633 3236 PD9568a 1649032 1563971 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV51788518 COSM5752712 99403070 c.1786C>G p.P596A Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99615 Confirmed somatic variant 27135926 NS NS ENSP00000275493.2:p.Pro596Ala ENST00000275493.6:c.1786C>G 7:g.55165343C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T3022 2658418 2518577 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51770269 COSM5710629 132578546 c.880G>A p.G294R Substitution - Missense 38 7:55156541-55156541 + - PATHOGENIC .9949 Confirmed somatic variant 27149842 NS NS 74.83 ENSP00000395243.3:p.Gly294Arg ENST00000454757.6:c.880G>A 7:g.55156541G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876648 2876648 2731163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 132548474 c.2117C>T p.T706I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000395243.3:p.Thr706Ile ENST00000454757.6:c.2117C>T 7:g.55174789C>T EGFR ENST00000275493.6 3633 3236 P-0008179-T01-IM5 2787021 2644444 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51799199 COSM1251020 99380942 c.1774G>A p.V592I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000275493.2:p.Val592Ile ENST00000275493.6:c.1774G>A 7:g.55165331G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T3064 2658265 2518424 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51804131 COSM4680403 132560266 c.3475A>C p.S1159R Substitution - Missense 38 7:55205594-55205594 + - PATHOGENIC .82773 Confirmed somatic variant 27149842 NS NS 75.5 ENSP00000395243.3:p.Ser1159Arg ENST00000454757.6:c.3475A>C 7:g.55205594A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1044282 1044282 960623 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-E1-A7Z2-01 2457427 2320264 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 58 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 P-0002689-T01-IM3 2718933 2577754 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51835394 COSM6923820 99439722 c.3154A>G p.R1052G Substitution - Missense het 38 7:55201774-55201774 + - .5653 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg1052Gly ENST00000275493.6:c.3154A>G 7:g.55201774A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003030-T01-IM3 2719239 2578060 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CC-UT-171T 2856959 2712259 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV105111007 COSM9520897 132598897 c.2510C>T p.A837V Substitution - Missense 38 7:55192785-55192785 + - PATHOGENIC .9499 Confirmed somatic variant 32271170 surgery-fixed primary ENSP00000395243.3:p.Ala837Val ENST00000454757.6:c.2510C>T 7:g.55192785C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011383-T01-IM5 2726979 2585800 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152759 2152759 2021769 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152759 2152759 2021769 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51836903 COSM3734670 132552557 c.2294G>C p.G765A Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98511 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Gly765Ala ENST00000454757.6:c.2294G>C 7:g.55181438G>C EGFR ENST00000275493.6 3633 3236 2876599 2876599 2731114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 99388191 c.2389T>A p.C797S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 59 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2389T>A 7:g.55181398T>A EGFR ENST00000275493.6 3633 3236 2876599 2876599 2731114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 59 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009948-T01-IM5 2725774 2584595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1089891 1089891 1004838 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17784875 surgery-fixed primary 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011189-T01-IM5 2726806 2585627 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2811958 2811958 2668495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion metastasis 79 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2696516 2696516 2555420 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28201779 surgery fresh/frozen NS 68 ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914582 914582 832031 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51861444 COSM13007 133203258 c.2200_2201delinsTT p.G734F Substitution - Missense het 38 7:55181344-55181345 + - Confirmed somatic variant 15788655 surgery fresh/frozen primary 80 ENSP00000415559.1:p.Gly734Phe ENST00000455089.5:c.2200_2201delinsTT 7:g.55181344_55181345delinsTT EGFR ENST00000275493.6 3633 3236 P-0010566-T01-IM5 2726268 2585089 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 ATL065 2488691 2351340 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm adult_T_cell_lymphoma-leukaemia NS NS y COSV51779734 COSM133203 132559785 c.2270T>C p.V757A Substitution - Missense 38 7:55181414-55181414 + - PATHOGENIC .95834 Confirmed somatic variant 26437031 NS NS 54 ENSP00000395243.3:p.Val757Ala ENST00000454757.6:c.2270T>C 7:g.55181414T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002296-T01-IM3 2718583 2577404 prostate NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51800946 COSM6921640 132556733 c.2144T>C p.L715P Substitution - Missense het 38 7:55174816-55174816 + - PATHOGENIC .99068 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu715Pro ENST00000454757.6:c.2144T>C 7:g.55174816T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876598 2876598 2731113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 133219858 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 41 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2255G>C 7:g.55181399G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876598 2876598 2731113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 41 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1109737 1109737 1023647 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 81 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006280-T01-IM5 2722658 2581479 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1052760 1052760 968831 soft_tissue fibrous_tissue_and_uncertain_origin NS NS malignant_fibrous_histiocytoma-pleomorphic_sarcoma storiform_pleomorphic NS NS n COSV51831473 COSM24671 133238141 c.1969G>A p.A657T Substitution - Missense 38 7:55173963-55173963 + - PATHOGENIC .97244 Confirmed somatic variant 17376509 surgery - NOS NS ENSP00000415559.1:p.Ala657Thr ENST00000455089.5:c.1969G>A 7:g.55173963G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1109741 1109741 1023651 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 50 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010801-T01-IM5 2726469 2585290 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-WS012-T14 2869947 2724944 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110458 COSM9657212 133262598 c.1316_1317delinsTT p.S439F Substitution - Missense 38 7:55160291-55160292 + - Confirmed somatic variant 26950094 surgery - NOS NS 82 ENSP00000415559.1:p.Ser439Phe ENST00000455089.5:c.1316_1317delinsTT 7:g.55160291_55160292delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1589267 1589267 1510421 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51823061 COSM133148 133268550 c.1993A>G p.T665A Substitution - Missense 38 7:55173987-55173987 + - PATHOGENIC .91254 Confirmed somatic variant 22026926 surgery fresh/frozen NS ENSP00000415559.1:p.Thr665Ala ENST00000455089.5:c.1993A>G 7:g.55173987A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009258-T01-IM5 2725216 2584037 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51838693 COSM6967815 133212863 c.2750G>A p.R917H Substitution - Missense het 38 7:55200352-55200352 + - PATHOGENIC .99038 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg917His ENST00000455089.5:c.2750G>A 7:g.55200352G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1472953 1472953 1396652 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51803731 COSM28604 133205257 c.2371C>T p.R791C Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .95213 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000415559.1:p.Arg791Cys ENST00000455089.5:c.2371C>T 7:g.55191755C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1472953 1472953 1396652 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51765351 COSM53292 133205261 c.2473C>T p.H825Y Substitution - Missense 38 7:55191857-55191857 + - PATHOGENIC .96355 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000415559.1:p.His825Tyr ENST00000455089.5:c.2473C>T 7:g.55191857C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1472953 1472953 1396652 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51803719 COSM53291 133205251 c.2350G>A p.E784K Substitution - Missense 38 7:55191734-55191734 + - PATHOGENIC .98912 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000415559.1:p.Glu784Lys ENST00000455089.5:c.2350G>A 7:g.55191734G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 IGC-01-1037 2662275 2522399 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51838271 COSM6515024 132550652 c.125G>A p.G42D Substitution - Missense 38 7:55142322-55142322 + - PATHOGENIC .98106 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000395243.3:p.Gly42Asp ENST00000454757.6:c.125G>A 7:g.55142322G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152697 2152697 2021707 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2840583 2840583 2696143 breast NS NS NS carcinoma HER-positive_carcinoma NS NS n COSM6843699 178389322 c.? p.A289T Substitution - Missense + - Confirmed somatic variant 31905165 surgery-fixed NS ENSP00000275493.2:p.Ala289Thr EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006541-T02-IM5 2722917 2581738 NS NS NS NS malignant_melanoma NS NS NS n COSV51823220 COSM13179 133214404 c.1945C>T p.P649S Substitution - Missense het 38 7:55173939-55173939 + - PATHOGENIC .97389 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Pro649Ser ENST00000455089.5:c.1945C>T 7:g.55173939C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812109 2812109 2668564 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 59 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 945808 945808 862334 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 16144918 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1516694 1516694 1439288 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21575252 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-19-1388-01 2178164 2046462 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289486 COSM7485141 132597694 c.1689G>C p.W563C Substitution - Missense 38 7:55165381-55165381 + - PATHOGENIC .98435 Confirmed somatic variant 329 NS NS 58 ENSP00000395243.3:p.Trp563Cys ENST00000454757.6:c.1689G>C 7:g.55165381G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920022 920022 837101 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001131-T01-IM3 2716689 2575510 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006789-T01-IM5 2723169 2581990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51786456 COSM6954013 132578470 c.2129C>G p.A710G Substitution - Missense het 38 7:55174801-55174801 + - PATHOGENIC .99346 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ala710Gly ENST00000454757.6:c.2129C>G 7:g.55174801C>G EGFR ENST00000275493.6 3633 3236 T3527 2296234 2161837 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51798634 COSM4680402 99388377 c.3439G>A p.V1147I Substitution - Missense 38 7:55205423-55205423 + - NEUTRAL .18974 Confirmed somatic variant 25344691 NS NS 73.91 ENSP00000275493.2:p.Val1147Ile ENST00000275493.6:c.3439G>A 7:g.55205423G>A EGFR ENST00000275493.6 3633 3236 P-0005929-T01-IM5 2722311 2581132 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1468646 1468646 1392397 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002294-T02-IM5 2719498 2578319 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51817765 COSM6959438 132556314 c.1667G>A p.G556E Substitution - Missense het 38 7:55165359-55165359 + - PATHOGENIC .9907 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly556Glu ENST00000454757.6:c.1667G>A 7:g.55165359G>A EGFR ENST00000275493.6 3633 3236 2152799 2152799 2021809 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458678 1458678 1382653 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-EE-A2MF-06 2339957 2204940 skin NS NS NS malignant_melanoma NS NS NS y COSV51776559 COSM4892884 99381163 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 540 NS NS 39 ENSP00000275493.2:p.Pro100Ser ENST00000275493.6:c.298C>T 7:g.55143362C>T EGFR ENST00000275493.6 3633 3236 TCGA-EE-A2MF-06 2339957 2204940 skin NS NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 99381173 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 540 NS NS 39 ENSP00000275493.2:p.Ser116Phe ENST00000275493.6:c.347C>T 7:g.55143411C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 D023P058 2788447 2645739 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSV51802272 COSM13425 132564786 c.2170G>A p.V724M Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .98024 Confirmed somatic variant 28120820 surgery-fixed primary ENSP00000395243.3:p.Val724Met ENST00000454757.6:c.2170G>A 7:g.55181314G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982861 982861 898580 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783354 COSM6196860 132564677 c.415A>G p.N139D Substitution - Missense 38 7:55143479-55143479 + - PATHOGENIC .81387 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000395243.3:p.Asn139Asp ENST00000454757.6:c.415A>G 7:g.55143479A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471556 1471556 1395295 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783384 COSM6196863 132564691 c.2129C>T p.A710V Substitution - Missense 38 7:55174801-55174801 + - PATHOGENIC .99151 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000395243.3:p.Ala710Val ENST00000454757.6:c.2129C>T 7:g.55174801C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783368 COSM6196862 132564686 c.2086C>T p.P696S Substitution - Missense 38 7:55174758-55174758 + - PATHOGENIC .99382 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000395243.3:p.Pro696Ser ENST00000454757.6:c.2086C>T 7:g.55174758C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783348 COSM6196859 132564673 c.380C>T p.A127V Substitution - Missense 38 7:55143444-55143444 + - NEUTRAL .27751 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000395243.3:p.Ala127Val ENST00000454757.6:c.380C>T 7:g.55143444C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152779 2152779 2021789 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0003030-T01-IM3 2719239 2578060 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2076199 2076199 1955012 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 24396447 bronchoalveolar lavage fluid NS 82 ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S00833 1759198 1663946 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51796349 COSM317275 132567852 c.1792A>G p.I598V Substitution - Missense 38 7:55172990-55172990 + - PATHOGENIC .91771 Confirmed somatic variant 22941188 fresh/frozen - NOS NS 77 ENSP00000395243.3:p.Ile598Val ENST00000454757.6:c.1792A>G 7:g.55172990A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1048210 1048210 964438 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51795112 COSM23633 132573436 c.2141T>A p.I714N Substitution - Missense 38 7:55174813-55174813 + - PATHOGENIC .99182 Confirmed somatic variant 17238183 surgery fresh/frozen NS 74 ENSP00000395243.3:p.Ile714Asn ENST00000454757.6:c.2141T>A 7:g.55174813T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007088-T02-IM5 2723461 2582282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51796464 COSM6959367 132567247 c.1985T>G p.L662W Substitution - Missense het 38 7:55173979-55173979 + - PATHOGENIC .97615 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu662Trp ENST00000454757.6:c.1985T>G 7:g.55173979T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007088-T02-IM5 2723461 2582282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007088-T02-IM5 2723461 2582282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 914582 914582 832031 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51861444 COSM13007 99374834 c.2335_2336delinsTT p.G779F Substitution - Missense het 38 7:55181344-55181345 + - Confirmed somatic variant 15788655 surgery fresh/frozen primary 80 ENSP00000275493.2:p.Gly779Phe ENST00000275493.6:c.2335_2336delinsTT 7:g.55181344_55181345delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P122 2072582 1951937 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 55.2 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009830-T01-IM5 2725668 2584489 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 132555528 c.620G>A p.R207H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Arg207His ENST00000454757.6:c.620G>A 7:g.55154018G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009824-T01-IM5 2725661 2584482 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004523-T01-IM5 2786950 2644373 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51780877 COSM26717 133203719 c.2444A>T p.K815I Substitution - Missense 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000415559.1:p.Lys815Ile ENST00000455089.5:c.2444A>T 7:g.55191828A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009830-T01-IM5 2725668 2584489 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51862034 COSM6970970 132557820 c.2780C>T p.A927V Substitution - Missense het 38 7:55200382-55200382 + - PATHOGENIC .98929 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ala927Val ENST00000454757.6:c.2780C>T 7:g.55200382C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CTS47 2393061 2255892 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 59 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876607 2876607 2731122 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV105110405 COSM9869915 132601866 c.2240T>G p.L747R Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .95324 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000395243.3:p.Leu747Arg ENST00000454757.6:c.2240T>G 7:g.55181384T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876607 2876607 2731122 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876607 2876607 2731122 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51766509 COSM5945664 132563575 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2255G>C 7:g.55181399G>C EGFR ENST00000275493.6 3633 3236 GC13 2896794 2751142 placenta NS NS NS choriocarcinoma NS NS NS y COSV105863774 COSM9953649 99382445 c.446G>T p.R149L Substitution - Missense 38 7:55146627-55146627 + - PATHOGENIC .93954 Confirmed somatic variant 33319857 surgery-fixed metastasis 39 ENSP00000275493.2:p.Arg149Leu ENST00000275493.6:c.446G>T 7:g.55146627G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A017-T-S10 2757375 2615994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 56 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0014404-T01-IM6 2803908 2660658 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51806557 COSM6919399 133250140 c.2660G>A p.R887H Substitution - Missense het 38 7:55198810-55198810 + - PATHOGENIC .99081 Confirmed somatic variant 29316426 surgery-fixed primary 62 ENSP00000415559.1:p.Arg887His ENST00000455089.5:c.2660G>A 7:g.55198810G>A EGFR ENST00000275493.6 3633 3236 2876598 2876598 2731113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 99392475 c.2390G>C p.C797S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 41 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2390G>C 7:g.55181399G>C EGFR ENST00000275493.6 3633 3236 2876598 2876598 2731113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 41 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460137 1460137 1384014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001249 1001249 918472 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001913-T01-IM3 2803768 2660519 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV99294960 COSM9112898 132564793 c.3319G>C p.D1107H Substitution - Missense het 38 7:55205438-55205438 + - .61067 Confirmed somatic variant 29316426 surgery-fixed primary 46 ENSP00000395243.3:p.Asp1107His ENST00000454757.6:c.3319G>C 7:g.55205438G>C EGFR ENST00000275493.6 3633 3236 P-0006280-T01-IM5 2722658 2581479 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005256 1005256 922468 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51794784 COSM13182 132548944 c.2068G>A p.G690S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Confirmed somatic variant 16720329 surgery-fixed primary 53 ENSP00000395243.3:p.Gly690Ser ENST00000454757.6:c.2068G>A 7:g.55174740G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006622-T01-IM5 2723002 2581823 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51845994 COSM5530405 132547619 c.1498G>A p.E500K Substitution - Missense het 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Glu500Lys ENST00000454757.6:c.1498G>A 7:g.55163734G>A EGFR ENST00000275493.6 3633 3236 1052760 1052760 968831 soft_tissue fibrous_tissue_and_uncertain_origin NS NS malignant_fibrous_histiocytoma-pleomorphic_sarcoma storiform_pleomorphic NS NS n COSV51831473 COSM24671 99411534 c.2104G>A p.A702T Substitution - Missense 38 7:55173963-55173963 + - PATHOGENIC .97244 Confirmed somatic variant 17376509 surgery - NOS NS ENSP00000275493.2:p.Ala702Thr ENST00000275493.6:c.2104G>A 7:g.55173963G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EY-A2OM-01 2198301 2066579 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99285698 COSM9064376 132560859 c.698A>G p.D233G Substitution - Missense 38 7:55154096-55154096 + - PATHOGENIC .95224 Confirmed somatic variant 419 NS NS 55 ENSP00000395243.3:p.Asp233Gly ENST00000454757.6:c.698A>G 7:g.55154096A>G EGFR ENST00000275493.6 3633 3236 1589267 1589267 1510421 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51823061 COSM133148 99445059 c.2128A>G p.T710A Substitution - Missense 38 7:55173987-55173987 + - PATHOGENIC .91254 Confirmed somatic variant 22026926 surgery fresh/frozen NS ENSP00000275493.2:p.Thr710Ala ENST00000275493.6:c.2128A>G 7:g.55173987A>G EGFR ENST00000275493.6 3633 3236 P-0009258-T01-IM5 2725216 2584037 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51838693 COSM6967815 99384285 c.2885G>A p.R962H Substitution - Missense het 38 7:55200352-55200352 + - PATHOGENIC .99038 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg962His ENST00000275493.6:c.2885G>A 7:g.55200352G>A EGFR ENST00000275493.6 3633 3236 P-0009258-T01-IM5 2725216 2584037 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51838710 COSM6967835 99384291 c.3406C>G p.P1136A Substitution - Missense het 38 7:55205390-55205390 + - PATHOGENIC .97767 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Pro1136Ala ENST00000275493.6:c.3406C>G 7:g.55205390C>G EGFR ENST00000275493.6 3633 3236 1472953 1472953 1396652 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51803719 COSM53291 99377257 c.2485G>A p.E829K Substitution - Missense 38 7:55191734-55191734 + - PATHOGENIC .98912 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000275493.2:p.Glu829Lys ENST00000275493.6:c.2485G>A 7:g.55191734G>A EGFR ENST00000275493.6 3633 3236 1472953 1472953 1396652 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51803731 COSM28604 99377260 c.2506C>T p.R836C Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .95213 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000275493.2:p.Arg836Cys ENST00000275493.6:c.2506C>T 7:g.55191755C>T EGFR ENST00000275493.6 3633 3236 1472953 1472953 1396652 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51765351 COSM53292 99377267 c.2608C>T p.H870Y Substitution - Missense 38 7:55191857-55191857 + - PATHOGENIC .96355 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000275493.2:p.His870Tyr ENST00000275493.6:c.2608C>T 7:g.55191857C>T EGFR ENST00000275493.6 3633 3236 P-0010801-T01-IM5 2726469 2585290 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 5-WS012-T14 2869947 2724944 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110458 COSM9657212 99439512 c.1451_1452delinsTT p.S484F Substitution - Missense 38 7:55160291-55160292 + - Confirmed somatic variant 26950094 surgery - NOS NS 82 ENSP00000275493.2:p.Ser484Phe ENST00000275493.6:c.1451_1452delinsTT 7:g.55160291_55160292delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002218-T02-IM5 2719490 2578311 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0006541-T02-IM5 2722917 2581738 NS NS NS NS malignant_melanoma NS NS NS n COSV51823220 COSM13179 99386001 c.2080C>T p.P694S Substitution - Missense het 38 7:55173939-55173939 + - PATHOGENIC .97389 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Pro694Ser ENST00000275493.6:c.2080C>T 7:g.55173939C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-CV-7103-01 2193635 2061913 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99291703 COSM8371626 132580074 c.112C>G p.L38V Substitution - Missense 38 7:55142309-55142309 + - PATHOGENIC .94561 Confirmed somatic variant 627 NS NS 49 ENSP00000395243.3:p.Leu38Val ENST00000454757.6:c.112C>G 7:g.55142309C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152783 2152783 2021793 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000435-T01-IM3 2715283 2574104 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51776947 COSM6910370 132564250 c.2362T>A p.L788M Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .36784 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu788Met ENST00000454757.6:c.2362T>A 7:g.55191746T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A103-T-S31 2757419 2616003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1486988 1486988 1410606 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51816100 COSM13430 133227287 c.2380G>A p.A794T Substitution - Missense 38 7:55191764-55191764 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 63 ENSP00000415559.1:p.Ala794Thr ENST00000455089.5:c.2380G>A 7:g.55191764G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1486988 1486988 1410606 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51782636 COSM85961 133203897 c.2383G>A p.A795T Substitution - Missense 38 7:55191767-55191767 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 63 ENSP00000415559.1:p.Ala795Thr ENST00000455089.5:c.2383G>A 7:g.55191767G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-0656 2108024 1985885 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 133205223 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Ala244Asp ENST00000455089.5:c.731C>A 7:g.55154129C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Pat_41_B 2513797 2376166 NS NS NS NS malignant_melanoma NS NS NS y COSV51772860 COSM5872872 132580122 c.548C>T p.P183L Substitution - Missense 38 7:55152600-55152600 + - PATHOGENIC .99115 Confirmed somatic variant 24265153 surgery-fixed NS 76 ENSP00000395243.3:p.Pro183Leu ENST00000454757.6:c.548C>T 7:g.55152600C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089890 1089890 1004837 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17784875 surgery-fixed primary 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 600 2131840 2005904 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51777649 COSM3721610 133248817 c.473G>A p.G158E Substitution - Missense 38 7:55151342-55151342 + - PATHOGENIC .98938 Confirmed somatic variant 23619168 fresh/frozen - NOS NS 57 ENSP00000415559.1:p.Gly158Glu ENST00000455089.5:c.473G>A 7:g.55151342G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FP-A4BE-01 2197995 2066273 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51785413 COSM1176673 133211383 c.620G>A p.R207H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 541 NS NS 55 ENSP00000415559.1:p.Arg207His ENST00000455089.5:c.620G>A 7:g.55154018G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489230 1489230 1412388 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830809 COSM85993 132579933 c.2125A>G p.K709E Substitution - Missense 38 7:55174797-55174797 + - PATHOGENIC .99211 Confirmed somatic variant 20881644 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Lys709Glu ENST00000454757.6:c.2125A>G 7:g.55174797A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003702-T02-IM5 2720190 2579011 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51831642 COSM1496684 132560351 c.853G>A p.E285K Substitution - Missense het 38 7:55155928-55155928 + - PATHOGENIC .94538 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Glu285Lys ENST00000454757.6:c.853G>A 7:g.55155928G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006915-T01-IM5 2723295 2582116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006915-T01-IM5 2723295 2582116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-D1-A103-01 1783494 1687493 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99294091 COSM9081690 133217957 c.1853G>T p.G618V Substitution - Missense 38 7:55173051-55173051 + - PATHOGENIC .792 Confirmed somatic variant 419 fresh/frozen - NOS primary 87 ENSP00000415559.1:p.Gly618Val ENST00000455089.5:c.1853G>T 7:g.55173051G>T EGFR ENST00000275493.6 3633 3236 1471556 1471556 1395295 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006029-T01-IM5 2783109 2640892 prostate NS NS NS carcinoma NS NS NS n COSV51862288 COSM6947601 132583027 c.2599T>G p.S867A Substitution - Missense het 38 7:55198749-55198749 + - PATHOGENIC .906 Confirmed somatic variant 28825054 surgery-fixed metastasis 74 ENSP00000395243.3:p.Ser867Ala ENST00000454757.6:c.2599T>G 7:g.55198749T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 3 897182 814805 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152779 2152779 2021789 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 460 898390 816002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P122 2072582 1951937 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 55.2 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-76-6661-01 2120394 1994630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51814881 COSM3929116 133224708 c.799G>T p.G267W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 329 NS NS 54 ENSP00000415559.1:p.Gly267Trp ENST00000455089.5:c.799G>T 7:g.55155874G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-76-6661-01 2120394 1994630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 133206295 c.775C>T p.H259Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 NS NS 54 ENSP00000415559.1:p.His259Tyr ENST00000455089.5:c.775C>T 7:g.55155850C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2905703 2905703 2759959 lung left_upper_lobe NS NS other bronchiolar_adenoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 33400370 surgery-fixed NS 76 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2905703 2905703 2759959 lung left_upper_lobe NS NS other bronchiolar_adenoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 33400370 surgery-fixed NS 76 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A TFAP2A ENST00000482890.5 1314 11742 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105902772 COSM10012977 139175439 c.721C>A p.P241T Substitution - Missense 38 6:10404551-10404551 - - PATHOGENIC .96956 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000418541.1:p.Pro241Thr ENST00000482890.5:c.721C>A 6:g.10404551G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876617 2876617 2731132 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + Yes PATHOGENIC .98253 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C SPTA1 ENST00000643759.1 7260 11272 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV63523825 COSM4975995 176713395 c.7202G>A p.R2401Q Substitution - Missense 38 1:158611322-158611322 - - NEUTRAL .29923 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000495214.1:p.Arg2401Gln ENST00000643759.1:c.7202G>A 1:g.158611322C>T EGFR ENST00000275493.6 3633 3236 P-0009824-T01-IM5 2725661 2584482 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0004523-T01-IM5 2786950 2644373 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51780877 COSM26717 99375410 c.2579A>T p.K860I Substitution - Missense 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000275493.2:p.Lys860Ile ENST00000275493.6:c.2579A>T 7:g.55191828A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Br247T 1313059 1223968 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827490 COSM39163 133223244 c.1772G>A p.C591Y Substitution - Missense het 38 7:55171201-55171201 + - PATHOGENIC .98251 Confirmed somatic variant 18772396 surgery - NOS primary 39 ENSP00000415559.1:p.Cys591Tyr ENST00000455089.5:c.1772G>A 7:g.55171201G>A EGFR ENST00000275493.6 3633 3236 CTS47 2393061 2255892 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 59 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SJDES007-R1 2294507 2160534 bone scapula NS NS Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour NS NS NS y COSV51785438 COSM3366978 133244411 c.2360G>A p.R787H Substitution - Missense 38 7:55191744-55191744 + - PATHOGENIC .9403 Confirmed somatic variant 25186949 NS primary 17 ENSP00000415559.1:p.Arg787His ENST00000455089.5:c.2360G>A 7:g.55191744G>A EGFR ENST00000275493.6 3633 3236 P-0014404-T01-IM6 2803908 2660658 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51806557 COSM6919399 99426383 c.2795G>A p.R932H Substitution - Missense het 38 7:55198810-55198810 + - PATHOGENIC .99081 Confirmed somatic variant 29316426 surgery-fixed primary 62 ENSP00000275493.2:p.Arg932His ENST00000275493.6:c.2795G>A 7:g.55198810G>A F7_ENST00000541084 ENST00000541084.5 1149 3544 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105916177 COSM10012857 154493660 c.571G>A p.E191K Substitution - Missense 38 13:113118430-113118430 + - NEUTRAL .06932 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000442051.2:p.Glu191Lys ENST00000541084.5:c.571G>A 13:g.113118430G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004813 1004813 922025 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16140420 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM15 2144555 2013769 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 24285547 surgery fresh/frozen primary 73 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002965-T01-IM3 2719174 2577995 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51819502 COSM6925302 133260247 c.3010T>C p.C1004R Substitution - Missense het 38 7:55201765-55201765 + - PATHOGENIC .9732 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Cys1004Arg ENST00000455089.5:c.3010T>C 7:g.55201765T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-CH-5765-01 1797170 1698917 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51795500 COSM1131544 133245340 c.557G>C p.C186S Substitution - Missense 38 7:55152609-55152609 + - PATHOGENIC .99547 Confirmed somatic variant 435 fresh/frozen - NOS primary 55 ENSP00000415559.1:p.Cys186Ser ENST00000455089.5:c.557G>C 7:g.55152609G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 IGC-04-1136 2662303 2522427 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51809481 COSM6530127 133219034 c.856G>C p.G286R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .97571 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000415559.1:p.Gly286Arg ENST00000455089.5:c.856G>C 7:g.55155931G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MaPT05 2491636 2354277 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51771223 COSM3929114 132554477 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000395243.3:p.Glu84Val ENST00000454757.6:c.251A>T 7:g.55143315A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007864-T01-IM5 2724078 2582899 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0002218-T02-IM5 2719490 2578311 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CH-LA5 2211431 2079634 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24449147 surgery fresh/frozen NS 59 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812069 2812069 2668544 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 circulating tumour NS 44 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DCG_17 2664395 2524449 central_nervous_system cerebellum NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779794 COSM53264 133215961 c.2039C>T p.T680M Substitution - Missense 38 7:55174033-55174033 + - PATHOGENIC .97744 Confirmed somatic variant 28852847 surgery fresh/frozen NS 77 ENSP00000415559.1:p.Thr680Met ENST00000455089.5:c.2039C>T 7:g.55174033C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489245 1489245 1412403 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004989 1004989 922201 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489256 1489256 1412414 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_C26 1863707 1754598 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51777901 COSM1187305 132553556 c.2297C>T p.S766F Substitution - Missense 38 7:55181441-55181441 + - PATHOGENIC .97194 Confirmed somatic variant 22975805 surgery fresh/frozen primary 61 ENSP00000395243.3:p.Ser766Phe ENST00000454757.6:c.2297C>T 7:g.55181441C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_C26 1863707 1754598 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 61 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000894-T01-IM3 2716206 2575027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777111 COSM33725 133215620 c.2474A>G p.H825R Substitution - Missense het 38 7:55191858-55191858 + - PATHOGENIC .97748 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.His825Arg ENST00000455089.5:c.2474A>G 7:g.55191858A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000894-T01-IM3 2716206 2575027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000894-T01-IM3 2716206 2575027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51822498 COSM3266565 133238887 c.782C>T p.S261L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ser261Leu ENST00000455089.5:c.782C>T 7:g.55155857C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EXTERN_MELA_20140530_012 2839372 2695138 skin NS NS NS malignant_melanoma NS NS NS y COSV104577175 COSM9448596 132557344 c.3371A>G p.N1124S Substitution - Missense 38 7:55205490-55205490 + - PATHOGENIC .97146 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000395243.3:p.Asn1124Ser ENST00000454757.6:c.3371A>G 7:g.55205490A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-ER-A42L-06 2456271 2319108 skin NS NS NS malignant_melanoma NS NS NS y COSV99287971 COSM7900658 133235349 c.1646C>T p.T549I Substitution - Missense 38 7:55165338-55165338 + - PATHOGENIC .94394 Confirmed somatic variant 540 NS metastasis 49 ENSP00000415559.1:p.Thr549Ile ENST00000455089.5:c.1646C>T 7:g.55165338C>T EGFR ENST00000275493.6 3633 3236 T3110 2658365 2518524 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51837186 COSM1090861 99388940 c.442G>A p.V148M Substitution - Missense 38 7:55146623-55146623 + - PATHOGENIC .99004 Confirmed somatic variant 27149842 NS NS 60.33 ENSP00000275493.2:p.Val148Met ENST00000275493.6:c.442G>A 7:g.55146623G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876615 2876615 2731130 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 53 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876615 2876615 2731130 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 133213822 c.2018T>A p.L673Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Confirmed somatic variant 29506987 circulating tumour NS 53 ENSP00000415559.1:p.Leu673Gln ENST00000455089.5:c.2018T>A 7:g.55174012T>A EGFR ENST00000275493.6 3633 3236 945794 945794 862320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Confirmed somatic variant 16144918 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000435-T01-IM3 2829184 2684999 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51776947 COSM6910370 132564250 c.2362T>A p.L788M Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .36784 Confirmed somatic variant 30205045 surgery-fixed metastasis 54 ENSP00000395243.3:p.Leu788Met ENST00000454757.6:c.2362T>A 7:g.55191746T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005228-T01-IM5 2721631 2580452 skin NS NS NS malignant_melanoma NS NS NS n COSV51814970 COSM6942061 132584222 c.3319G>A p.D1107N Substitution - Missense het 38 7:55205438-55205438 + - .52145 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Asp1107Asn ENST00000454757.6:c.3319G>A 7:g.55205438G>A EGFR ENST00000275493.6 3633 3236 A103-T-S31 2757419 2616003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-0691 2108027 1985888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774829 COSM1451549 133204902 c.632A>G p.D211G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Asp211Gly ENST00000455089.5:c.632A>G 7:g.55154030A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Thyroid-CN-WZ037T 2635098 2495494 thyroid NS NS NS carcinoma NS NS NS y COSV51794993 COSM6399094 133221088 c.5G>A p.R2Q Substitution - Missense 38 7:55019282-55019282 + - NEUTRAL .46409 Confirmed somatic variant 676 NS primary 40 ENSP00000415559.1:p.Arg2Gln ENST00000455089.5:c.5G>A 7:g.55019282G>A EGFR ENST00000275493.6 3633 3236 1486988 1486988 1410606 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51782636 COSM85961 99375603 c.2518G>A p.A840T Substitution - Missense 38 7:55191767-55191767 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 63 ENSP00000275493.2:p.Ala840Thr ENST00000275493.6:c.2518G>A 7:g.55191767G>A EGFR ENST00000275493.6 3633 3236 1486988 1486988 1410606 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51816100 COSM13430 99401741 c.2515G>A p.A839T Substitution - Missense 38 7:55191764-55191764 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 63 ENSP00000275493.2:p.Ala839Thr ENST00000275493.6:c.2515G>A 7:g.55191764G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152765 2152765 2021775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV51854311 COSM133198 132563487 c.2108G>A p.R703K Substitution - Missense het 38 7:55174780-55174780 + - PATHOGENIC .99476 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000395243.3:p.Arg703Lys ENST00000454757.6:c.2108G>A 7:g.55174780G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV99294040 COSM9120802 132563454 c.379G>A p.A127T Substitution - Missense het 38 7:55143443-55143443 + - NEUTRAL .01752 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000395243.3:p.Ala127Thr ENST00000454757.6:c.379G>A 7:g.55143443G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV104368998 COSM9232920 132563469 c.751C>T p.P251S Substitution - Missense het 38 7:55154149-55154149 + - PATHOGENIC .98876 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000395243.3:p.Pro251Ser ENST00000454757.6:c.751C>T 7:g.55154149C>T EGFR ENST00000275493.6 3633 3236 TCGA-12-0656 2108024 1985885 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 99377226 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Ala289Asp ENST00000275493.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV51803771 COSM14068 132563495 c.2173G>A p.D725N Substitution - Missense het 38 7:55181317-55181317 + - PATHOGENIC .97623 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000395243.3:p.Asp725Asn ENST00000454757.6:c.2173G>A 7:g.55181317G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV51776282 COSM1168015 132547141 c.2123C>T p.P708L Substitution - Missense het 38 7:55174795-55174795 + - PATHOGENIC .98745 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000395243.3:p.Pro708Leu ENST00000454757.6:c.2123C>T 7:g.55174795C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811973 2811973 2668500 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 31534501 pleural effusion metastasis 64 ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1595808 1595808 1516605 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51793896 COSM22954 132561366 c.2189G>A p.C730Y Substitution - Missense hom 38 7:55181333-55181333 + - PATHOGENIC .97278 Confirmed somatic variant 16551849 surgery-fixed NS 70 ENSP00000395243.3:p.Cys730Tyr ENST00000454757.6:c.2189G>A 7:g.55181333G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006622-T01-IM5 2786996 2644419 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51845994 COSM5530405 133202750 c.1498G>A p.E500K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000415559.1:p.Glu500Lys ENST00000455089.5:c.1498G>A 7:g.55163734G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194733 1194733 1106628 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 16760 1423719 1333747 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001703-T01-IM3 2717826 2576647 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51782832 COSM3881808 132578587 c.604G>A p.D202N Substitution - Missense het 38 7:55152656-55152656 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Asp202Asn ENST00000454757.6:c.604G>A 7:g.55152656G>A EGFR ENST00000275493.6 3633 3236 2901987 2901987 2756229 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2901987 2901987 2756229 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Leu861Arg EGFR ENST00000275493.6 3633 3236 2901987 2901987 2756229 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM5010368 178378709 c.? p.C797S Substitution - Missense + Yes Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Cys797Ser EGFR ENST00000275493.6 3633 3236 1089890 1089890 1004837 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17784875 surgery-fixed primary 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 600 2131840 2005904 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51777649 COSM3721610 99424568 c.608G>A p.G203E Substitution - Missense 38 7:55151342-55151342 + - PATHOGENIC .98938 Confirmed somatic variant 23619168 fresh/frozen - NOS NS 57 ENSP00000275493.2:p.Gly203Glu ENST00000275493.6:c.608G>A 7:g.55151342G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SDC7 2564876 2426270 salivary_gland NS NS NS carcinoma salivary_duct_carcinoma NS NS y COSV51792147 COSM5988249 133230746 c.1035G>T p.Q345H Substitution - Missense 38 7:55156795-55156795 + - NEUTRAL .3446 Confirmed somatic variant 27103403 surgery fresh/frozen recurrent ENSP00000415559.1:p.Gln345His ENST00000455089.5:c.1035G>T 7:g.55156795G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1044288 1044288 960629 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-FP-A4BE-01 2197995 2066273 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51785413 COSM1176673 99382805 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 541 NS NS 55 ENSP00000275493.2:p.Arg252His ENST00000275493.6:c.755G>A 7:g.55154018G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EJ-5495-01 1797184 1698931 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51809907 COSM1131542 132570537 c.3419G>T p.G1140V Substitution - Missense 38 7:55205538-55205538 + - PATHOGENIC .94469 Confirmed somatic variant 435 fresh/frozen - NOS primary 68 ENSP00000395243.3:p.Gly1140Val ENST00000454757.6:c.3419G>T 7:g.55205538G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T2250 2658595 2518754 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51769145 COSM3266559 132580106 c.739G>A p.V247M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 27149842 NS NS 62.08 ENSP00000395243.3:p.Val247Met ENST00000454757.6:c.739G>A 7:g.55154137G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-13-0900-01 1474861 1398560 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51795875 COSM116882 133217075 c.1990G>C p.E664Q Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98409 Confirmed somatic variant 21720365 331 NS primary 59 ENSP00000415559.1:p.Glu664Gln ENST00000455089.5:c.1990G>C 7:g.55173984G>C EGFR ENST00000275493.6 3633 3236 P-0006915-T01-IM5 2723295 2582116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 P-0006915-T01-IM5 2723295 2582116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A CHN1 ENST00000409900.7 1380 1943 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105886981 COSM10012859 124561868 c.1324C>T p.R442W Substitution - Missense 38 2:174800172-174800172 - - PATHOGENIC .98155 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000386741.3:p.Arg442Trp ENST00000409900.7:c.1324C>T 2:g.174800172G>A EGFR ENST00000275493.6 3633 3236 TCGA-D1-A103-01 1783494 1687493 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99294091 COSM9081690 99390261 c.1988G>T p.G663V Substitution - Missense 38 7:55173051-55173051 + - PATHOGENIC .792 Confirmed somatic variant 419 fresh/frozen - NOS primary 87 ENSP00000275493.2:p.Gly663Val ENST00000275493.6:c.1988G>T 7:g.55173051G>T EGFR ENST00000275493.6 3633 3236 460 898390 816002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876065 2876065 2730580 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 IGC-02-1183 2662280 2522404 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51792209 COSM6548316 133214125 c.2069G>T p.G690V Substitution - Missense 38 7:55174741-55174741 + - PATHOGENIC .99891 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000415559.1:p.Gly690Val ENST00000455089.5:c.2069G>T 7:g.55174741G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GYWU_831 2771306 2629499 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV99290440 COSM7410173 133243622 c.3038G>A p.C1013Y Substitution - Missense 38 7:55202527-55202527 + - NEUTRAL .29295 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000415559.1:p.Cys1013Tyr ENST00000455089.5:c.3038G>A 7:g.55202527G>A EGFR ENST00000275493.6 3633 3236 TCGA-76-6661-01 2120394 1994630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 99378201 c.910C>T p.H304Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 NS NS 54 ENSP00000275493.2:p.His304Tyr ENST00000275493.6:c.910C>T 7:g.55155850C>T EGFR ENST00000275493.6 3633 3236 TCGA-76-6661-01 2120394 1994630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51814881 COSM3929116 99399609 c.934G>T p.G312W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 329 NS NS 54 ENSP00000275493.2:p.Gly312Trp ENST00000275493.6:c.934G>T 7:g.55155874G>T EGFR ENST00000275493.6 3633 3236 2905703 2905703 2759959 lung left_upper_lobe NS NS other bronchiolar_adenoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 33400370 surgery-fixed NS 76 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2905703 2905703 2759959 lung left_upper_lobe NS NS other bronchiolar_adenoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 33400370 surgery-fixed NS 76 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2876617 2876617 2731132 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + Yes PATHOGENIC .98253 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006886-T01-IM5 2723266 2582087 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006886-T01-IM5 2723266 2582087 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767386 COSM18423 132564484 c.2365G>T p.V789L Substitution - Missense het 38 7:55191749-55191749 + - PATHOGENIC .9903 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000395243.3:p.Val789Leu ENST00000454757.6:c.2365G>T 7:g.55191749G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002446-T01-IM3 2718721 2577542 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 Br247T 1313059 1223968 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827490 COSM39163 99397529 c.1907G>A p.C636Y Substitution - Missense het 38 7:55171201-55171201 + - PATHOGENIC .98251 Confirmed somatic variant 18772396 surgery - NOS primary 39 ENSP00000275493.2:p.Cys636Tyr ENST00000275493.6:c.1907G>A 7:g.55171201G>A EGFR ENST00000275493.6 3633 3236 SJDES007-R1 2294507 2160534 bone scapula NS NS Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour NS NS NS y COSV51785438 COSM3366978 99419308 c.2495G>A p.R832H Substitution - Missense 38 7:55191744-55191744 + - PATHOGENIC .9403 Confirmed somatic variant 25186949 NS primary 17 ENSP00000275493.2:p.Arg832His ENST00000275493.6:c.2495G>A 7:g.55191744G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Br20P 1312980 1223889 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51815967 COSM39522 133205184 c.520T>G p.C174G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 18772396 surgery - NOS primary 77 ENSP00000415559.1:p.Cys174Gly ENST00000455089.5:c.520T>G 7:g.55152572T>G EGFR ENST00000275493.6 3633 3236 1004813 1004813 922025 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16140420 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BS-A0UF-01 1783473 1687472 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51780766 COSM219795 133202085 c.2456C>T p.A819V Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .93098 Confirmed somatic variant 419 fresh/frozen - NOS primary 65 ENSP00000415559.1:p.Ala819Val ENST00000455089.5:c.2456C>T 7:g.55191840C>T EGFR ENST00000275493.6 3633 3236 P-0002965-T01-IM3 2719174 2577995 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51819502 COSM6925302 99437340 c.3145T>C p.C1049R Substitution - Missense het 38 7:55201765-55201765 + - PATHOGENIC .9732 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Cys1049Arg ENST00000275493.6:c.3145T>C 7:g.55201765T>C EGFR ENST00000275493.6 3633 3236 TCGA-CH-5765-01 1797170 1698917 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51795500 COSM1131544 99420505 c.692G>C p.C231S Substitution - Missense 38 7:55152609-55152609 + - PATHOGENIC .99547 Confirmed somatic variant 435 fresh/frozen - NOS primary 55 ENSP00000275493.2:p.Cys231Ser ENST00000275493.6:c.692G>C 7:g.55152609G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MaPT01s 2491582 2354223 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51775191 COSM1451530 132550172 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000395243.3:p.Gly63Arg ENST00000454757.6:c.187G>A 7:g.55142384G>A EGFR ENST00000275493.6 3633 3236 IGC-04-1136 2662303 2522427 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51809481 COSM6530127 99391424 c.991G>C p.G331R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .97571 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000275493.2:p.Gly331Arg ENST00000275493.6:c.991G>C 7:g.55155931G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920036 920036 837115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0007864-T01-IM5 2724078 2582899 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006151-T01-IM5 2722529 2581350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CH-LA5 2211431 2079634 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24449147 surgery fresh/frozen NS 59 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009587-T01-IM5 2725481 2584302 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009587-T01-IM5 2725481 2584302 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 DCG_17 2664395 2524449 central_nervous_system cerebellum NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779794 COSM53264 99387824 c.2174C>T p.T725M Substitution - Missense 38 7:55174033-55174033 + - PATHOGENIC .97744 Confirmed somatic variant 28852847 surgery fresh/frozen NS 77 ENSP00000275493.2:p.Thr725Met ENST00000275493.6:c.2174C>T 7:g.55174033C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 132563558 c.2239C>T p.L747F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000395243.3:p.Leu747Phe ENST00000454757.6:c.2239C>T 7:g.55181383C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 132557758 c.2018T>A p.L673Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000395243.3:p.Leu673Gln ENST00000454757.6:c.2018T>A 7:g.55174012T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 132560202 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 132563564 c.2240T>A p.L747H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000395243.3:p.Leu747His ENST00000454757.6:c.2240T>A 7:g.55181384T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 132548474 c.2117C>T p.T706I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000395243.3:p.Thr706Ile ENST00000454757.6:c.2117C>T 7:g.55174789C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 132563575 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2255G>C 7:g.55181399G>C EGFR ENST00000275493.6 3633 3236 P-0000894-T01-IM3 2716206 2575027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51822498 COSM3266565 99412489 c.917C>T p.S306L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ser306Leu ENST00000275493.6:c.917C>T 7:g.55155857C>T EGFR ENST00000275493.6 3633 3236 P-0000894-T01-IM3 2716206 2575027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777111 COSM33725 99387470 c.2609A>G p.H870R Substitution - Missense het 38 7:55191858-55191858 + - PATHOGENIC .97748 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.His870Arg ENST00000275493.6:c.2609A>G 7:g.55191858A>G EGFR ENST00000275493.6 3633 3236 P-0000894-T01-IM3 2716206 2575027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-ER-A42L-06 2456271 2319108 skin NS NS NS malignant_melanoma NS NS NS y COSV99287971 COSM7900658 99408269 c.1781C>T p.T594I Substitution - Missense 38 7:55165338-55165338 + - PATHOGENIC .94394 Confirmed somatic variant 540 NS metastasis 49 ENSP00000275493.2:p.Thr594Ile ENST00000275493.6:c.1781C>T 7:g.55165338C>T EGFR ENST00000275493.6 3633 3236 2876615 2876615 2731130 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 99385331 c.2153T>A p.L718Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Confirmed somatic variant 29506987 circulating tumour NS 53 ENSP00000275493.2:p.Leu718Gln ENST00000275493.6:c.2153T>A 7:g.55174012T>A EGFR ENST00000275493.6 3633 3236 2876615 2876615 2731130 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 53 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 Thyroid-CN-WZ037T 2635098 2495494 thyroid NS NS NS carcinoma NS NS NS y COSV51794993 COSM6399094 99394153 c.5G>A p.R2Q Substitution - Missense 38 7:55019282-55019282 + - NEUTRAL .46409 Confirmed somatic variant 676 NS primary 40 ENSP00000275493.2:p.Arg2Gln ENST00000275493.6:c.5G>A 7:g.55019282G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005254 1005254 922466 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51770694 COSM20891 133218993 c.2251G>A p.G751S Substitution - Missense 38 7:55181395-55181395 + - PATHOGENIC .98244 Confirmed somatic variant 16720329 surgery-fixed primary 67 ENSP00000415559.1:p.Gly751Ser ENST00000455089.5:c.2251G>A 7:g.55181395G>A EGFR ENST00000275493.6 3633 3236 TCGA-12-0691 2108027 1985888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774829 COSM1451549 99376761 c.767A>G p.D256G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Asp256Gly ENST00000275493.6:c.767A>G 7:g.55154030A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211133 1211133 1123001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen metastasis 67 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2152765 2152765 2021775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-14-1456 2108037 1985898 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 ESCC_BICR_010T 2456865 2319702 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51822386 COSM5436048 133259440 c.1439C>G p.S480C Substitution - Missense 38 7:55161574-55161574 + - PATHOGENIC .96861 Confirmed somatic variant 582 NS primary 70 ENSP00000415559.1:p.Ser480Cys ENST00000455089.5:c.1439C>G 7:g.55161574C>G EGFR ENST00000275493.6 3633 3236 P-0006622-T01-IM5 2786996 2644419 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51845994 COSM5530405 99374106 c.1633G>A p.E545K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000275493.2:p.Glu545Lys ENST00000275493.6:c.1633G>A 7:g.55163734G>A EGFR ENST00000275493.6 3633 3236 1194733 1194733 1106628 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 16760 1423719 1333747 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460108 1460108 1383985 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 132548474 c.2117C>T p.T706I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000395243.3:p.Thr706Ile ENST00000454757.6:c.2117C>T 7:g.55174789C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920033 920033 837112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 50 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920033 920033 837112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765252 COSM13009 133225791 c.1991A>G p.E664G Substitution - Missense hom 38 7:55173985-55173985 + - PATHOGENIC .97508 Confirmed somatic variant 15623594 surgery fresh/frozen NS 50 ENSP00000415559.1:p.Glu664Gly ENST00000455089.5:c.1991A>G 7:g.55173985A>G EGFR ENST00000275493.6 3633 3236 SDC7 2564876 2426270 salivary_gland NS NS NS carcinoma salivary_duct_carcinoma NS NS y COSV51792147 COSM5988249 99404839 c.1170G>T p.Q390H Substitution - Missense 38 7:55156795-55156795 + - NEUTRAL .3446 Confirmed somatic variant 27103403 surgery fresh/frozen recurrent ENSP00000275493.2:p.Gln390His ENST00000275493.6:c.1170G>T 7:g.55156795G>T EGFR ENST00000275493.6 3633 3236 1044288 1044288 960629 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EX01M 2653306 2513433 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS metastasis 58.5 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A065-T-S09 2757402 2616000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-13-0900-01 1474861 1398560 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51795875 COSM116882 99389211 c.2125G>C p.E709Q Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98409 Confirmed somatic variant 21720365 331 NS primary 59 ENSP00000275493.2:p.Glu709Gln ENST00000275493.6:c.2125G>C 7:g.55173984G>C EGFR ENST00000275493.6 3633 3236 I2L-P7-Tumor-Organoid 2433490 2296371 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51828974 COSM5358463 99405745 c.3388A>C p.S1130R Substitution - Missense het 38 7:55205372-55205372 + - PATHOGENIC .96828 Confirmed somatic variant 25957691 NS NS 81 ENSP00000275493.2:p.Ser1130Arg ENST00000275493.6:c.3388A>C 7:g.55205372A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811951 2811951 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 133206840 c.2447T>G p.L816R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 31534501 surgery-fixed NS 69 ENSP00000415559.1:p.Leu816Arg ENST00000455089.5:c.2447T>G 7:g.55191831T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811951 2811951 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 31534501 surgery-fixed NS 69 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876054 2876054 2730569 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 44 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011149-T01-IM5 2726775 2585596 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51770500 COSM6979164 133251169 c.2225A>T p.Q742L Substitution - Missense het 38 7:55181369-55181369 + - PATHOGENIC .97936 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Gln742Leu ENST00000455089.5:c.2225A>T 7:g.55181369A>T EGFR ENST00000275493.6 3633 3236 2876065 2876065 2730580 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 GYWU_831 2771306 2629499 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV99290440 COSM7410173 99418403 c.3173G>A p.C1058Y Substitution - Missense 38 7:55202527-55202527 + - NEUTRAL .29295 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000275493.2:p.Cys1058Tyr ENST00000275493.6:c.3173G>A 7:g.55202527G>A EGFR ENST00000275493.6 3633 3236 IGC-02-1183 2662280 2522404 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51792209 COSM6548316 99385659 c.2204G>T p.G735V Substitution - Missense 38 7:55174741-55174741 + - PATHOGENIC .99891 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000275493.2:p.Gly735Val ENST00000275493.6:c.2204G>T 7:g.55174741G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982870 982870 898589 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-5856-01 2120270 1994506 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 58 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CRC104post 2730749 2589518 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV104577027 COSM9413135 133220677 c.1259G>A p.G420E Substitution - Missense 38 7:55160234-55160234 + - NEUTRAL .11765 Confirmed somatic variant 26416732 xenograft metastasis 62 ENSP00000415559.1:p.Gly420Glu ENST00000455089.5:c.1259G>A 7:g.55160234G>A EGFR ENST00000275493.6 3633 3236 P-0002446-T01-IM3 2718721 2577542 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0743-01 1337857 1248242 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 69 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 Br20P 1312980 1223889 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51815967 COSM39522 99377187 c.655T>G p.C219G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 18772396 surgery - NOS primary 77 ENSP00000275493.2:p.Cys219Gly ENST00000275493.6:c.655T>G 7:g.55152572T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002647-T01-IM3 2718893 2577714 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0881-01 1337868 1248253 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-14-1823-01 1338013 1248398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 58 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001303-T02-IM3 2717028 2575849 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51807743 COSM133179 132566093 c.1930G>A p.V644M Substitution - Missense het 38 7:55173924-55173924 + - PATHOGENIC .9843 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Val644Met ENST00000454757.6:c.1930G>A 7:g.55173924G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001303-T02-IM3 2717028 2575849 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-BS-A0UF-01 1783473 1687472 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51780766 COSM219795 99373292 c.2591C>T p.A864V Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .93098 Confirmed somatic variant 419 fresh/frozen - NOS primary 65 ENSP00000275493.2:p.Ala864Val ENST00000275493.6:c.2591C>T 7:g.55191840C>T C1RL_ENST00000545337 ENST00000545337.1 564 21265 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV56923985 COSM2101631 153862565 c.406C>T p.R136W Substitution - Missense 38 12:7101982-7101982 - - NEUTRAL .10223 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000442611.1:p.Arg136Trp ENST00000545337.1:c.406C>T 12:g.7101982G>A EGFR ENST00000275493.6 3633 3236 920036 920036 837115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 05-123E2 2575154 2436491 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51804536 COSM5997191 132574627 c.3169G>A p.A1057T Substitution - Missense 38 7:55205288-55205288 + - NEUTRAL .17823 Confirmed somatic variant 26928463 autopsy - NOS metastasis 80 ENSP00000395243.3:p.Ala1057Thr ENST00000454757.6:c.3169G>A 7:g.55205288G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001255 1001255 918478 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A114-T-S59 2757429 2616005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 61 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1880596 1880596 1770990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23403410 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1790524 1790524 1693503 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0009587-T01-IM5 2725481 2584302 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 P-0009587-T01-IM5 2725481 2584302 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-14-1395-01 2120295 1994531 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51827895 COSM3412174 133207223 c.550A>T p.S184C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 329 NS NS 52 ENSP00000415559.1:p.Ser184Cys ENST00000455089.5:c.550A>T 7:g.55152602A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A062-T-S23 2757399 2615999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1044289 1044289 960630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A014-T-S08 2758132 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 16965 1423769 1333797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51774819 COSM35840 133207029 c.1816G>A p.V606M Substitution - Missense het 38 7:55173014-55173014 + - PATHOGENIC .99458 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Val606Met ENST00000455089.5:c.1816G>A 7:g.55173014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 16965 1423769 1333797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004729-T01-IM5 2721133 2579954 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876622 2876622 2731137 lung NS NS NS carcinoma NS NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 29506987 circulating tumour NS 51 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876622 2876622 2731137 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 51 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876622 2876622 2731137 lung NS NS NS carcinoma NS NS NS n COSV51785510 COSM6957413 133202339 c.967G>A p.D323N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 29506987 circulating tumour NS 51 ENSP00000415559.1:p.Asp323Asn ENST00000455089.5:c.967G>A 7:g.55156628G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1486990 1486990 1410608 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51849884 COSM13192 132555587 c.2293G>A p.G765S Substitution - Missense 38 7:55181437-55181437 + - PATHOGENIC .98229 Confirmed somatic variant 16567021 surgery-fixed primary 68 ENSP00000395243.3:p.Gly765Ser ENST00000454757.6:c.2293G>A 7:g.55181437G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1486990 1486990 1410608 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51767182 COSM27110 132554778 c.2221G>A p.V741M Substitution - Missense 38 7:55181365-55181365 + - PATHOGENIC .97319 Confirmed somatic variant 16567021 surgery-fixed primary 68 ENSP00000395243.3:p.Val741Met ENST00000454757.6:c.2221G>A 7:g.55181365G>A EGFR ENST00000275493.6 3633 3236 1005254 1005254 922466 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51770694 COSM20891 99391373 c.2386G>A p.G796S Substitution - Missense 38 7:55181395-55181395 + - PATHOGENIC .98244 Confirmed somatic variant 16720329 surgery-fixed primary 67 ENSP00000275493.2:p.Gly796Ser ENST00000275493.6:c.2386G>A 7:g.55181395G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0125 2107938 1985799 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002026-T01-IM3 2718333 2577154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T2935 2658562 2518721 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51820069 COSM6652271 133212046 c.1796C>T p.P599L Substitution - Missense 38 7:55172994-55172994 + - PATHOGENIC .98245 Confirmed somatic variant 27149842 NS NS 64.16 ENSP00000415559.1:p.Pro599Leu ENST00000455089.5:c.1796C>T 7:g.55172994C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001123-T01-IM3 2716671 2575492 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1211133 1211133 1123001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen metastasis 67 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876657 2876657 2731172 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 ESCC_BICR_010T 2456865 2319702 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51822386 COSM5436048 99436535 c.1574C>G p.S525C Substitution - Missense 38 7:55161574-55161574 + - PATHOGENIC .96861 Confirmed somatic variant 582 NS primary 70 ENSP00000275493.2:p.Ser525Cys ENST00000275493.6:c.1574C>G 7:g.55161574C>G KIFC3_ENST00000540079 ENST00000540079.6 2175 6326 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65551650 COSM971903 151978463 c.388C>T p.R130W Substitution - Missense 38 16:57771269-57771269 - - PATHOGENIC .87712 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000438805.2:p.Arg130Trp ENST00000540079.6:c.388C>T 16:g.57771269G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-93-A4JP-01 2385674 2248506 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 417 NS primary 64 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 100641 1520659 1443034 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20668451 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1109740 1109740 1023650 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 47 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920033 920033 837112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765252 COSM13009 99400543 c.2126A>G p.E709G Substitution - Missense hom 38 7:55173985-55173985 + - PATHOGENIC .97508 Confirmed somatic variant 15623594 surgery fresh/frozen NS 50 ENSP00000275493.2:p.Glu709Gly ENST00000275493.6:c.2126A>G 7:g.55173985A>G EGFR ENST00000275493.6 3633 3236 920033 920033 837112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 50 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005148-T01-IM5 2721554 2580375 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005148-T01-IM5 2721554 2580375 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 EX01M 2653306 2513433 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS metastasis 58.5 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 A065-T-S09 2757402 2616000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876648 2876648 2731163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 133203473 c.2117C>T p.T706I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000415559.1:p.Thr706Ile ENST00000455089.5:c.2117C>T 7:g.55174789C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T3022 2658418 2518577 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51770269 COSM5710629 133238945 c.880G>A p.G294R Substitution - Missense 38 7:55156541-55156541 + - PATHOGENIC .9949 Confirmed somatic variant 27149842 NS NS 74.83 ENSP00000415559.1:p.Gly294Arg ENST00000455089.5:c.880G>A 7:g.55156541G>A EGFR ENST00000275493.6 3633 3236 2811951 2811951 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 31534501 surgery-fixed NS 69 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2811951 2811951 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 99378740 c.2582T>G p.L861R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 31534501 surgery-fixed NS 69 ENSP00000275493.2:p.Leu861Arg ENST00000275493.6:c.2582T>G 7:g.55191831T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 112707 1520735 1443110 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20668451 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206739 1206739 1118617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51854030 COSM29578 132558093 c.2438T>A p.L813Q Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .9803 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Leu813Gln ENST00000454757.6:c.2438T>A 7:g.55191822T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206739 1206739 1118617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206739 1206739 1118617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206739 1206739 1118617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876054 2876054 2730569 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 44 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011383-T01-IM5 2726979 2585800 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152759 2152759 2021769 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152759 2152759 2021769 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51836903 COSM3734670 133207578 c.2294G>C p.G765A Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98511 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Gly765Ala ENST00000455089.5:c.2294G>C 7:g.55181438G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1044282 1044282 960623 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0011149-T01-IM5 2726775 2585596 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51770500 COSM6979164 99427705 c.2360A>T p.Q787L Substitution - Missense het 38 7:55181369-55181369 + - PATHOGENIC .97936 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Gln787Leu ENST00000275493.6:c.2360A>T 7:g.55181369A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-E1-A7Z2-01 2457427 2320264 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 58 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CC-UT-171T 2856959 2712259 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV105111007 COSM9520897 133262750 c.2510C>T p.A837V Substitution - Missense 38 7:55192785-55192785 + - PATHOGENIC .9499 Confirmed somatic variant 32271170 surgery-fixed primary ENSP00000415559.1:p.Ala837Val ENST00000455089.5:c.2510C>T 7:g.55192785C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009948-T01-IM5 2725774 2584595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1089891 1089891 1004838 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17784875 surgery-fixed primary 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982870 982870 898589 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CRC104post 2730749 2589518 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV104577027 COSM9413135 99393507 c.1394G>A p.G465E Substitution - Missense 38 7:55160234-55160234 + - NEUTRAL .11765 Confirmed somatic variant 26416732 xenograft metastasis 62 ENSP00000275493.2:p.Gly465Glu ENST00000275493.6:c.1394G>A 7:g.55160234G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-0743-01 1337857 1248242 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 69 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 TCGA-06-0743-01 1337857 1248242 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51853321 COSM3412170 99414200 c.478G>A p.E160K Substitution - Missense 38 7:55146659-55146659 + - PATHOGENIC .9774 Confirmed somatic variant 329 surgery fresh/frozen NS 69 ENSP00000275493.2:p.Glu160Lys ENST00000275493.6:c.478G>A 7:g.55146659G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011189-T01-IM5 2726806 2585627 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P146 2072599 1951954 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 48 ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 P-0002647-T01-IM3 2718893 2577714 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000609-T01-IM3 2715617 2574438 soft_tissue fibrous_tissue_and_uncertain_origin NS NS desmoplastic_small_round_cell_tumour NS NS NS n COSV51861952 COSM6911610 132567666 c.2776A>G p.M926V Substitution - Missense het 38 7:55200378-55200378 + - PATHOGENIC .99305 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Met926Val ENST00000454757.6:c.2776A>G 7:g.55200378A>G EGFR ENST00000275493.6 3633 3236 TCGA-06-0881-01 1337868 1248253 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 ATL065 2488691 2351340 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm adult_T_cell_lymphoma-leukaemia NS NS y COSV51779734 COSM133203 133215950 c.2270T>C p.V757A Substitution - Missense 38 7:55181414-55181414 + - PATHOGENIC .95834 Confirmed somatic variant 26437031 NS NS 54 ENSP00000415559.1:p.Val757Ala ENST00000455089.5:c.2270T>C 7:g.55181414T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1040350 1040350 956927 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_II NS NS n COSV51790148 COSM22555 132554437 c.1895G>A p.R632H Substitution - Missense 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000395243.3:p.Arg632His ENST00000454757.6:c.1895G>A 7:g.55173093G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002296-T01-IM3 2718583 2577404 prostate NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51800946 COSM6921640 133212767 c.2144T>C p.L715P Substitution - Missense het 38 7:55174816-55174816 + - PATHOGENIC .99068 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu715Pro ENST00000455089.5:c.2144T>C 7:g.55174816T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DF-A2KN-01 2457388 2320225 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99289848 COSM9047248 132561553 c.923C>T p.A308V Substitution - Missense 38 7:55156584-55156584 + - PATHOGENIC .99015 Confirmed somatic variant 419 NS primary ENSP00000395243.3:p.Ala308Val ENST00000454757.6:c.923C>T 7:g.55156584C>T EGFR ENST00000275493.6 3633 3236 A114-T-S59 2757429 2616005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005013 1005013 922225 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1790524 1790524 1693503 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-14-1395-01 2120295 1994531 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51827895 COSM3412174 99379092 c.685A>T p.S229C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 329 NS NS 52 ENSP00000275493.2:p.Ser229Cys ENST00000275493.6:c.685A>T 7:g.55152602A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1109741 1109741 1023651 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 50 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2591359 2591359 2452319 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591359 2591359 2452319 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 A062-T-S23 2757399 2615999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-B6-A0RQ-01 1899865 1788549 breast NS NS NS carcinoma NS NS NS y COSV51832348 COSM6974705 99420157 c.3602C>T p.A1201V Substitution - Missense 38 7:55205586-55205586 + - PATHOGENIC .8173 Confirmed somatic variant 414 fresh/frozen - NOS primary 68 ENSP00000275493.2:p.Ala1201Val ENST00000275493.6:c.3602C>T 7:g.55205586C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 IGC-01-1037 2662275 2522399 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51838271 COSM6515024 133205594 c.125G>A p.G42D Substitution - Missense 38 7:55142322-55142322 + - PATHOGENIC .98106 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000415559.1:p.Gly42Asp ENST00000455089.5:c.125G>A 7:g.55142322G>A EGFR ENST00000275493.6 3633 3236 1044289 1044289 960630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 16965 1423769 1333797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 16965 1423769 1333797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51774819 COSM35840 99378923 c.1951G>A p.V651M Substitution - Missense het 38 7:55173014-55173014 + - PATHOGENIC .99458 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Val651Met ENST00000275493.6:c.1951G>A 7:g.55173014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152697 2152697 2021707 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 P-0004729-T01-IM5 2721133 2579954 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876622 2876622 2731137 lung NS NS NS carcinoma NS NS NS n COSV51785510 COSM6957413 99373603 c.1102G>A p.D368N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 29506987 circulating tumour NS 51 ENSP00000275493.2:p.Asp368Asn ENST00000275493.6:c.1102G>A 7:g.55156628G>A EGFR ENST00000275493.6 3633 3236 2876622 2876622 2731137 lung NS NS NS carcinoma NS NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 29506987 circulating tumour NS 51 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2876622 2876622 2731137 lung NS NS NS carcinoma NS NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 51 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0001123-T01-IM3 2716671 2575492 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 T2935 2658562 2518721 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51820069 COSM6652271 99383430 c.1931C>T p.P644L Substitution - Missense 38 7:55172994-55172994 + - PATHOGENIC .98245 Confirmed somatic variant 27149842 NS NS 64.16 ENSP00000275493.2:p.Pro644Leu ENST00000275493.6:c.1931C>T 7:g.55172994C>T EGFR ENST00000275493.6 3633 3236 2876657 2876657 2731172 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812109 2812109 2668564 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 59 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FG-A70Z-01 2194226 2062504 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 53 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 T2946 2658354 2518513 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777851 COSM1205052 99395067 c.494G>A p.R165Q Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .0375 Confirmed somatic variant 27149842 NS NS 78.66 ENSP00000275493.2:p.Arg165Gln ENST00000275493.6:c.494G>A 7:g.55146675G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GB066T 2634031 2494427 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51808309 COSM6355435 132564160 c.3415A>G p.N1139D Substitution - Missense 38 7:55205534-55205534 + - PATHOGENIC .97599 Confirmed somatic variant 672 NS primary ENSP00000395243.3:p.Asn1139Asp ENST00000454757.6:c.3415A>G 7:g.55205534A>G EGFR ENST00000275493.6 3633 3236 2876648 2876648 2731163 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 99375118 c.2252C>T p.T751I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000275493.2:p.Thr751Ile ENST00000275493.6:c.2252C>T 7:g.55174789C>T EGFR ENST00000275493.6 3633 3236 T3022 2658418 2518577 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51770269 COSM5710629 99412561 c.1015G>A p.G339R Substitution - Missense 38 7:55156541-55156541 + - PATHOGENIC .9949 Confirmed somatic variant 27149842 NS NS 74.83 ENSP00000275493.2:p.Gly339Arg ENST00000275493.6:c.1015G>A 7:g.55156541G>A EGFR ENST00000275493.6 3633 3236 945818 945818 862344 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 16144918 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002490-T01-IM3 2718762 2577583 NS NS NS NS malignant_melanoma NS NS NS n COSV51822498 COSM3266565 132578509 c.782C>T p.S261L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ser261Leu ENST00000454757.6:c.782C>T 7:g.55155857C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002490-T01-IM3 2718762 2577583 NS NS NS NS malignant_melanoma NS NS NS n COSV51822525 COSM6922832 132581780 c.1205C>T p.S402F Substitution - Missense het 38 7:55160180-55160180 + - .61329 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ser402Phe ENST00000454757.6:c.1205C>T 7:g.55160180C>T EGFR ENST00000275493.6 3633 3236 T3064 2658265 2518424 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51804131 COSM4680403 99388284 c.3610A>C p.S1204R Substitution - Missense 38 7:55205594-55205594 + - PATHOGENIC .82773 Confirmed somatic variant 27149842 NS NS 75.5 ENSP00000275493.2:p.Ser1204Arg ENST00000275493.6:c.3610A>C 7:g.55205594A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-19-1388-01 2178164 2046462 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289486 COSM7485141 133261361 c.1689G>C p.W563C Substitution - Missense 38 7:55165381-55165381 + - PATHOGENIC .98435 Confirmed somatic variant 329 NS NS 58 ENSP00000415559.1:p.Trp563Cys ENST00000455089.5:c.1689G>C 7:g.55165381G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011389-T01-IM5 2726985 2585806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011389-T01-IM5 2726985 2585806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM19-I3 2813467 2669859 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 P-0011383-T01-IM5 2726979 2585800 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 2152759 2152759 2021769 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51836903 COSM3734670 99379420 c.2429G>C p.G810A Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98511 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Gly810Ala ENST00000275493.6:c.2429G>C 7:g.55181438G>C EGFR ENST00000275493.6 3633 3236 2152759 2152759 2021769 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001131-T01-IM3 2716689 2575510 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CC-UT-171T 2856959 2712259 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV105111007 COSM9520897 99439660 c.2645C>T p.A882V Substitution - Missense 38 7:55192785-55192785 + - PATHOGENIC .9499 Confirmed somatic variant 32271170 surgery-fixed primary ENSP00000275493.2:p.Ala882Val ENST00000275493.6:c.2645C>T 7:g.55192785C>T EGFR ENST00000275493.6 3633 3236 1044282 1044282 960623 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006789-T01-IM5 2723169 2581990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51786456 COSM6954013 133238799 c.2129C>G p.A710G Substitution - Missense het 38 7:55174801-55174801 + - PATHOGENIC .99346 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ala710Gly ENST00000455089.5:c.2129C>G 7:g.55174801C>G EGFR ENST00000275493.6 3633 3236 TCGA-E1-A7Z2-01 2457427 2320264 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 58 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 P-0009948-T01-IM5 2725774 2584595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1089891 1089891 1004838 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17784875 surgery-fixed primary 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920022 920022 837101 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0011189-T01-IM5 2726806 2585627 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2665867 2665867 2525575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM4766152 178379591 c.? p.R324L Substitution - Missense + - Confirmed somatic variant 28979142 surgery - NOS NS ENSP00000275493.2:p.Arg324Leu EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2492720 2492720 2355335 skin ear NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 132556505 c.2890G>A p.D964N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 26286987 surgery fresh/frozen primary ENSP00000395243.3:p.Asp964Asn ENST00000454757.6:c.2890G>A 7:g.55201266G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002294-T02-IM5 2719498 2578319 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51817765 COSM6959438 133212267 c.1667G>A p.G556E Substitution - Missense het 38 7:55165359-55165359 + - PATHOGENIC .9907 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly556Glu ENST00000455089.5:c.1667G>A 7:g.55165359G>A EGFR ENST00000275493.6 3633 3236 ATL065 2488691 2351340 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm adult_T_cell_lymphoma-leukaemia NS NS y COSV51779734 COSM133203 99387809 c.2405T>C p.V802A Substitution - Missense 38 7:55181414-55181414 + - PATHOGENIC .95834 Confirmed somatic variant 26437031 NS NS 54 ENSP00000275493.2:p.Val802Ala ENST00000275493.6:c.2405T>C 7:g.55181414T>C EGFR ENST00000275493.6 3633 3236 P-0002296-T01-IM3 2718583 2577404 prostate NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51800946 COSM6921640 99384175 c.2279T>C p.L760P Substitution - Missense het 38 7:55174816-55174816 + - PATHOGENIC .99068 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu760Pro ENST00000275493.6:c.2279T>C 7:g.55174816T>C EGFR ENST00000275493.6 3633 3236 1010429 1010429 927603 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 17001163 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 D023P058 2788447 2645739 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSV51802272 COSM13425 133221191 c.2170G>A p.V724M Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .98024 Confirmed somatic variant 28120820 surgery-fixed primary ENSP00000415559.1:p.Val724Met ENST00000455089.5:c.2170G>A 7:g.55181314G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876618 2876618 2731133 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 29506987 circulating tumour NS 60 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876618 2876618 2731133 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + Yes PATHOGENIC .98253 Confirmed somatic variant 29506987 circulating tumour NS 60 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 2856497 2856497 2711824 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSM9517089 178387888 c.? p.C818Y Substitution - Missense + - Confirmed somatic variant 31799787 surgery-fixed NS ENSP00000275493.2:p.Cys818Tyr EGFR ENST00000275493.6 3633 3236 1109741 1109741 1023651 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 50 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002614-T02-IM5 2719521 2578342 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense het 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002614-T02-IM5 2719521 2578342 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982861 982861 898580 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 IGC-01-1037 2662275 2522399 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51838271 COSM6515024 99377544 c.125G>A p.G42D Substitution - Missense 38 7:55142322-55142322 + - PATHOGENIC .98106 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000275493.2:p.Gly42Asp ENST00000275493.6:c.125G>A 7:g.55142322G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LICA-CN-HCC121T 2634168 2494564 liver NS NS NS other neoplasm NS NS y COSV51825459 COSM122789 132558008 c.1288A>G p.I430V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Confirmed somatic variant 660 NS primary 49 ENSP00000395243.3:p.Ile430Val ENST00000454757.6:c.1288A>G 7:g.55160263A>G EGFR ENST00000275493.6 3633 3236 2152697 2152697 2021707 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1589270 1589270 1510424 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51782403 COSM22951 132581124 c.2249T>C p.F750S Substitution - Missense 38 7:55181393-55181393 + - .67484 Confirmed somatic variant 22026926 surgery fresh/frozen NS ENSP00000395243.3:p.Phe750Ser ENST00000454757.6:c.2249T>C 7:g.55181393T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783368 COSM6196862 133221071 c.2086C>T p.P696S Substitution - Missense 38 7:55174758-55174758 + - PATHOGENIC .99382 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000415559.1:p.Pro696Ser ENST00000455089.5:c.2086C>T 7:g.55174758C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783348 COSM6196859 133221048 c.380C>T p.A127V Substitution - Missense 38 7:55143444-55143444 + - NEUTRAL .27751 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000415559.1:p.Ala127Val ENST00000455089.5:c.380C>T 7:g.55143444C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783354 COSM6196860 133221054 c.415A>G p.N139D Substitution - Missense 38 7:55143479-55143479 + - PATHOGENIC .81387 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000415559.1:p.Asn139Asp ENST00000455089.5:c.415A>G 7:g.55143479A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783384 COSM6196863 133221080 c.2129C>T p.A710V Substitution - Missense 38 7:55174801-55174801 + - PATHOGENIC .99151 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000415559.1:p.Ala710Val ENST00000455089.5:c.2129C>T 7:g.55174801C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2076199 2076199 1955012 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 24396447 bronchoalveolar lavage fluid NS 82 ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1048210 1048210 964438 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51795112 COSM23633 133231506 c.2141T>A p.I714N Substitution - Missense 38 7:55174813-55174813 + - PATHOGENIC .99182 Confirmed somatic variant 17238183 surgery fresh/frozen NS 74 ENSP00000415559.1:p.Ile714Asn ENST00000455089.5:c.2141T>A 7:g.55174813T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S00833 1759198 1663946 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51796349 COSM317275 133224623 c.1792A>G p.I598V Substitution - Missense 38 7:55172990-55172990 + - PATHOGENIC .91771 Confirmed somatic variant 22941188 fresh/frozen - NOS NS 77 ENSP00000415559.1:p.Ile598Val ENST00000455089.5:c.1792A>G 7:g.55172990A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007088-T02-IM5 2723461 2582282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007088-T02-IM5 2723461 2582282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51796464 COSM6959367 133223939 c.1985T>G p.L662W Substitution - Missense het 38 7:55173979-55173979 + - PATHOGENIC .97615 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu662Trp ENST00000455089.5:c.1985T>G 7:g.55173979T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007088-T02-IM5 2723461 2582282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1322265 1322265 1233152 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51788393 COSM13979 132563273 c.2035G>A p.G679S Substitution - Missense 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 19844187 surgery-fixed primary 52 ENSP00000395243.3:p.Gly679Ser ENST00000454757.6:c.2035G>A 7:g.55174029G>A EGFR ENST00000275493.6 3633 3236 2812109 2812109 2668564 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 59 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009830-T01-IM5 2725668 2584489 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51862034 COSM6970970 133213895 c.2780C>T p.A927V Substitution - Missense het 38 7:55200382-55200382 + - PATHOGENIC .98929 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ala927Val ENST00000455089.5:c.2780C>T 7:g.55200382C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009830-T01-IM5 2725668 2584489 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 133211383 c.620G>A p.R207H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Arg207His ENST00000455089.5:c.620G>A 7:g.55154018G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A017-T-S10 2757375 2615994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 56 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876607 2876607 2731122 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51766509 COSM5945664 133219858 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2255G>C 7:g.55181399G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876607 2876607 2731122 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV105110405 COSM9869915 133266042 c.2240T>G p.L747R Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .95324 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000415559.1:p.Leu747Arg ENST00000455089.5:c.2240T>G 7:g.55181384T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876607 2876607 2731122 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1179550 1179550 1091512 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005256 1005256 922468 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51794784 COSM13182 133203905 c.2068G>A p.G690S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Confirmed somatic variant 16720329 surgery-fixed primary 53 ENSP00000415559.1:p.Gly690Ser ENST00000455089.5:c.2068G>A 7:g.55174740G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460137 1460137 1384014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001249 1001249 918472 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2591331 2591331 2452291 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006622-T01-IM5 2723002 2581823 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51845994 COSM5530405 133202750 c.1498G>A p.E500K Substitution - Missense het 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Glu500Lys ENST00000455089.5:c.1498G>A 7:g.55163734G>A EGFR ENST00000275493.6 3633 3236 TCGA-19-1388-01 2178164 2046462 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289486 COSM7485141 99438502 c.1824G>C p.W608C Substitution - Missense 38 7:55165381-55165381 + - PATHOGENIC .98435 Confirmed somatic variant 329 NS NS 58 ENSP00000275493.2:p.Trp608Cys ENST00000275493.6:c.1824G>C 7:g.55165381G>C GOLGA6L10_ENST00000619556 ENST00000619556.4 1428 37228 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV73782728 COSM190514 167707177 c.451G>C p.E151Q Substitution - Missense 38 15:82345409-82345409 - - NEUTRAL .02811 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000483647.2:p.Glu151Gln ENST00000619556.4:c.451G>C 15:g.82345409C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-VS083-T1 2869916 2724913 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51776967 COSM6963220 132562155 c.1795C>T p.P599S Substitution - Missense 38 7:55172993-55172993 + - PATHOGENIC .96242 Confirmed somatic variant 26950094 surgery - NOS NS 72 ENSP00000395243.3:p.Pro599Ser ENST00000454757.6:c.1795C>T 7:g.55172993C>T EGFR ENST00000275493.6 3633 3236 P-0006789-T01-IM5 2723169 2581990 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51786456 COSM6954013 99412394 c.2264C>G p.A755G Substitution - Missense het 38 7:55174801-55174801 + - PATHOGENIC .99346 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ala755Gly ENST00000275493.6:c.2264C>G 7:g.55174801C>G EGFR ENST00000275493.6 3633 3236 P-0001131-T01-IM3 2716689 2575510 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0017699-T01-IM6 2830937 2686752 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51837290 COSM6921325 132566177 c.3200A>G p.N1067S Substitution - Missense 38 7:55205319-55205319 + - PATHOGENIC .95172 Confirmed somatic variant 30205045 surgery-fixed primary 38 ENSP00000395243.3:p.Asn1067Ser ENST00000454757.6:c.3200A>G 7:g.55205319A>G EGFR ENST00000275493.6 3633 3236 920022 920022 837101 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2591341 2591341 2452301 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591341 2591341 2452301 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-CV-7103-01 2193635 2061913 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99291703 COSM8371626 133241050 c.112C>G p.L38V Substitution - Missense 38 7:55142309-55142309 + - PATHOGENIC .94561 Confirmed somatic variant 627 NS NS 49 ENSP00000415559.1:p.Leu38Val ENST00000455089.5:c.112C>G 7:g.55142309C>G EGFR ENST00000275493.6 3633 3236 P-0002294-T02-IM5 2719498 2578319 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51817765 COSM6959438 99383672 c.1802G>A p.G601E Substitution - Missense het 38 7:55165359-55165359 + - PATHOGENIC .9907 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly601Glu ENST00000275493.6:c.1802G>A 7:g.55165359G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T2457 2658705 2518864 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51789934 COSM6652266 132563344 c.3041C>T p.P1014L Substitution - Missense 38 7:55202530-55202530 + - PATHOGENIC .92486 Confirmed somatic variant 27149842 NS NS 75.08 ENSP00000395243.3:p.Pro1014Leu ENST00000454757.6:c.3041C>T 7:g.55202530C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152783 2152783 2021793 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CTS131 2393051 2255882 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000435-T01-IM3 2715283 2574104 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51776947 COSM6910370 133220707 c.2362T>A p.L788M Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .36784 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu788Met ENST00000455089.5:c.2362T>A 7:g.55191746T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A8 2409506 2272386 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25112956 surgery fresh/frozen NS 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002695-T01-IM3 2718937 2577758 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51788017 COSM6923954 132619343 c.3127C>T p.P1043S Substitution - Missense het 38 7:55202616-55202616 + - PATHOGENIC .96386 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Pro1043Ser ENST00000454757.6:c.3127C>T 7:g.55202616C>T EGFR ENST00000275493.6 3633 3236 D023P058 2788447 2645739 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSV51802272 COSM13425 99394305 c.2305G>A p.V769M Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .98024 Confirmed somatic variant 28120820 surgery-fixed primary ENSP00000275493.2:p.Val769Met ENST00000275493.6:c.2305G>A 7:g.55181314G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876601 2876601 2731116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 surgery fresh/frozen NS 50 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876601 2876601 2731116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 132560202 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 surgery fresh/frozen NS 50 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876601 2876601 2731116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 surgery fresh/frozen NS 50 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458681 1458681 1382656 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FG-A4MW-01 2194412 2062690 central_nervous_system brain NS NS glioma NS NS NS y COSV51814881 COSM3929116 132567904 c.799G>T p.G267W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 545 NS NS 63 ENSP00000395243.3:p.Gly267Trp ENST00000454757.6:c.799G>T 7:g.55155874G>T EGFR ENST00000275493.6 3633 3236 982861 982861 898580 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1170515 1170515 1082649 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 19117057 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152762 2152762 2021772 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MBC_61 2662766 2522890 breast NS NS NS carcinoma ER-PR-positive_carcinoma NS NS y COSV51771306 COSM1318972 132562649 c.1778C>T p.T593M Substitution - Missense 38 7:55171207-55171207 + - NEUTRAL .03249 Confirmed somatic variant 28027327 fresh/frozen - NOS NS ENSP00000395243.3:p.Thr593Met ENST00000454757.6:c.1778C>T 7:g.55171207C>T EGFR ENST00000275493.6 3633 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783384 COSM6196863 99394136 c.2264C>T p.A755V Substitution - Missense 38 7:55174801-55174801 + - PATHOGENIC .99151 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000275493.2:p.Ala755Val ENST00000275493.6:c.2264C>T 7:g.55174801C>T EGFR ENST00000275493.6 3633 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783348 COSM6196859 99394100 c.380C>T p.A127V Substitution - Missense 38 7:55143444-55143444 + - NEUTRAL .27751 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000275493.2:p.Ala127Val ENST00000275493.6:c.380C>T 7:g.55143444C>T EGFR ENST00000275493.6 3633 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783354 COSM6196860 99394109 c.415A>G p.N139D Substitution - Missense 38 7:55143479-55143479 + - PATHOGENIC .81387 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000275493.2:p.Asn139Asp ENST00000275493.6:c.415A>G 7:g.55143479A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000630-T01-IM3 2715664 2574485 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000630-T01-IM3 2715664 2574485 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783368 COSM6196862 99394128 c.2221C>T p.P741S Substitution - Missense 38 7:55174758-55174758 + - PATHOGENIC .99382 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000275493.2:p.Pro741Ser ENST00000275493.6:c.2221C>T 7:g.55174758C>T EGFR ENST00000275493.6 3633 3236 2076199 2076199 1955012 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 24396447 bronchoalveolar lavage fluid NS 82 ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 S00833 1759198 1663946 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51796349 COSM317275 99399523 c.1927A>G p.I643V Substitution - Missense 38 7:55172990-55172990 + - PATHOGENIC .91771 Confirmed somatic variant 22941188 fresh/frozen - NOS NS 77 ENSP00000275493.2:p.Ile643Val ENST00000275493.6:c.1927A>G 7:g.55172990A>G EGFR ENST00000275493.6 3633 3236 1048210 1048210 964438 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51795112 COSM23633 99405507 c.2276T>A p.I759N Substitution - Missense 38 7:55174813-55174813 + - PATHOGENIC .99182 Confirmed somatic variant 17238183 surgery fresh/frozen NS 74 ENSP00000275493.2:p.Ile759Asn ENST00000275493.6:c.2276T>A 7:g.55174813T>A EGFR ENST00000275493.6 3633 3236 2591445 2591445 2452405 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591445 2591445 2452405 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-02-2466-01 2178184 2046482 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 61 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 P-0007088-T02-IM5 2723461 2582282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51796464 COSM6959367 99398539 c.2120T>G p.L707W Substitution - Missense het 38 7:55173979-55173979 + - PATHOGENIC .97615 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu707Trp ENST00000275493.6:c.2120T>G 7:g.55173979T>G EGFR ENST00000275493.6 3633 3236 P-0007088-T02-IM5 2723461 2582282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 P-0007088-T02-IM5 2723461 2582282 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007580-T01-IM5 2723865 2582686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007580-T01-IM5 2723865 2582686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780206 COSM12373 132553376 c.2024C>T p.S675F Substitution - Missense het 38 7:55174018-55174018 + - PATHOGENIC .9768 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ser675Phe ENST00000454757.6:c.2024C>T 7:g.55174018C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001254 1001254 918477 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0009830-T01-IM5 2725668 2584489 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 99382805 c.755G>A p.R252H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Arg252His ENST00000275493.6:c.755G>A 7:g.55154018G>A EGFR ENST00000275493.6 3633 3236 P-0009830-T01-IM5 2725668 2584489 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51862034 COSM6970970 99385410 c.2915C>T p.A972V Substitution - Missense het 38 7:55200382-55200382 + - PATHOGENIC .98929 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ala972Val ENST00000275493.6:c.2915C>T 7:g.55200382C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5 897197 814820 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876046 2876046 2730561 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 52 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BA-4075-01 2193631 2061909 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99292704 COSM8332917 132572511 c.1502C>A p.P501Q Substitution - Missense 38 7:55163738-55163738 + - PATHOGENIC .97378 Confirmed somatic variant 627 NS NS 49 ENSP00000395243.3:p.Pro501Gln ENST00000454757.6:c.1502C>A 7:g.55163738C>A EGFR ENST00000275493.6 3633 3236 2115535 2115535 1989779 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2876607 2876607 2731122 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV105110405 COSM9869915 99442731 c.2375T>G p.L792R Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .95324 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000275493.2:p.Leu792Arg ENST00000275493.6:c.2375T>G 7:g.55181384T>G EGFR ENST00000275493.6 3633 3236 2876607 2876607 2731122 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51766509 COSM5945664 99392475 c.2390G>C p.C797S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2390G>C 7:g.55181399G>C EGFR ENST00000275493.6 3633 3236 A017-T-S10 2757375 2615994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 56 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876607 2876607 2731122 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Pat_41_B 2513797 2376166 NS NS NS NS malignant_melanoma NS NS NS y COSV51772860 COSM5872872 133241196 c.548C>T p.P183L Substitution - Missense 38 7:55152600-55152600 + - PATHOGENIC .99115 Confirmed somatic variant 24265153 surgery-fixed NS 76 ENSP00000415559.1:p.Pro183Leu ENST00000455089.5:c.548C>T 7:g.55152600C>T EGFR ENST00000275493.6 3633 3236 1005256 1005256 922468 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51794784 COSM13182 99375617 c.2203G>A p.G735S Substitution - Missense 38 7:55174740-55174740 + - PATHOGENIC .99879 Confirmed somatic variant 16720329 surgery-fixed primary 53 ENSP00000275493.2:p.Gly735Ser ENST00000275493.6:c.2203G>A 7:g.55174740G>A EGFR ENST00000275493.6 3633 3236 1460137 1460137 1384014 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1001249 1001249 918472 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0001913-T01-IM3 2803768 2660519 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV99294960 COSM9112898 99394315 c.3454G>C p.D1152H Substitution - Missense het 38 7:55205438-55205438 + - .61067 Confirmed somatic variant 29316426 surgery-fixed primary 46 ENSP00000275493.2:p.Asp1152His ENST00000275493.6:c.3454G>C 7:g.55205438G>C EGFR ENST00000275493.6 3633 3236 P-0006622-T01-IM5 2723002 2581823 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51845994 COSM5530405 99374106 c.1633G>A p.E545K Substitution - Missense het 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Glu545Lys ENST00000275493.6:c.1633G>A 7:g.55163734G>A EGFR ENST00000275493.6 3633 3236 2115532 2115532 1989776 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003702-T02-IM5 2720190 2579011 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51831642 COSM1496684 133216418 c.853G>A p.E285K Substitution - Missense het 38 7:55155928-55155928 + - PATHOGENIC .94538 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Glu285Lys ENST00000455089.5:c.853G>A 7:g.55155928G>A EGFR ENST00000275493.6 3633 3236 2591333 2591333 2452293 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM6022462 178383117 c.? p.T751P Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003752-T03-IM5 2720240 2579061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003752-T03-IM5 2720240 2579061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006029-T01-IM5 2783109 2640892 prostate NS NS NS carcinoma NS NS NS n COSV51862288 COSM6947601 133244074 c.2599T>G p.S867A Substitution - Missense het 38 7:55198749-55198749 + - PATHOGENIC .906 Confirmed somatic variant 28825054 surgery-fixed metastasis 74 ENSP00000415559.1:p.Ser867Ala ENST00000455089.5:c.2599T>G 7:g.55198749T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 3 897182 814805 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812094 2812094 2668557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 132551401 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Confirmed somatic variant 31534501 pleural effusion NS 63 ENSP00000395243.3:p.Arg731His ENST00000454757.6:c.2192G>A 7:g.55181336G>A EGFR ENST00000275493.6 3633 3236 TCGA-CV-7103-01 2193635 2061913 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99291703 COSM8371626 99415333 c.112C>G p.L38V Substitution - Missense 38 7:55142309-55142309 + - PATHOGENIC .94561 Confirmed somatic variant 627 NS NS 49 ENSP00000275493.2:p.Leu38Val ENST00000275493.6:c.112C>G 7:g.55142309C>G EGFR ENST00000275493.6 3633 3236 2152783 2152783 2021793 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0000435-T01-IM3 2715283 2574104 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51776947 COSM6910370 99393548 c.2497T>A p.L833M Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .36784 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu833Met ENST00000275493.6:c.2497T>A 7:g.55191746T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-13-0912-01 1474988 1398687 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51781835 COSM174732 132552286 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 21720365 331 NS primary 58 ENSP00000395243.3:p.Glu114Lys ENST00000454757.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-13-0912-01 1474988 1398687 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51781835 COSM174732 132552286 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 331 NS primary 58 ENSP00000395243.3:p.Glu114Lys ENST00000454757.6:c.340G>A 7:g.55143404G>A NAGPA_ENST00000381955 ENST00000381955.7 1446 17378 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105888740 COSM10012899 115443817 c.482G>A p.S161N Substitution - Missense 38 16:5033333-5033333 - - NEUTRAL .21709 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000371381.3:p.Ser161Asn ENST00000381955.7:c.482G>A 16:g.5033333C>T EGFR ENST00000275493.6 3633 3236 Pat_41_B 2513797 2376166 NS NS NS NS malignant_melanoma NS NS NS y COSV51772860 COSM5872872 99415407 c.683C>T p.P228L Substitution - Missense 38 7:55152600-55152600 + - PATHOGENIC .99115 Confirmed somatic variant 24265153 surgery-fixed NS 76 ENSP00000275493.2:p.Pro228Leu ENST00000275493.6:c.683C>T 7:g.55152600C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 61 2497169 2359521 small_intestine duodenum NS NS adenoma NS NS NS y COSV51766928 COSM12718 133206642 c.2045A>G p.Y682C Substitution - Missense 38 7:55174039-55174039 + - PATHOGENIC .97626 Confirmed somatic variant 26806338 fresh/frozen - NOS primary ENSP00000415559.1:p.Tyr682Cys ENST00000455089.5:c.2045A>G 7:g.55174039A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1472954 1472954 1396653 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51816100 COSM13430 132569804 c.2380G>A p.A794T Substitution - Missense 38 7:55191764-55191764 + - PATHOGENIC .98912 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000395243.3:p.Ala794Thr ENST00000454757.6:c.2380G>A 7:g.55191764G>A EGFR ENST00000275493.6 3633 3236 TCGA-EY-A2OM-01 2198301 2066579 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99285698 COSM9064376 99389065 c.833A>G p.D278G Substitution - Missense 38 7:55154096-55154096 + - PATHOGENIC .95224 Confirmed somatic variant 419 NS NS 55 ENSP00000275493.2:p.Asp278Gly ENST00000275493.6:c.833A>G 7:g.55154096A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM15 2144555 2013769 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 24285547 surgery fresh/frozen primary 73 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489230 1489230 1412388 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830809 COSM85993 133240844 c.2125A>G p.K709E Substitution - Missense 38 7:55174797-55174797 + - PATHOGENIC .99211 Confirmed somatic variant 20881644 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Lys709Glu ENST00000455089.5:c.2125A>G 7:g.55174797A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Br112X 1313001 1223910 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 18772396 xenograft primary 48 ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MaPT05 2491636 2354277 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51771223 COSM3929114 133209833 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000415559.1:p.Glu84Val ENST00000455089.5:c.251A>T 7:g.55143315A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 OSCC-GB_00130111 2121052 1995288 upper_aerodigestive_tract mouth NS NS carcinoma NS NS NS y COSV51815394 COSM3715755 132556509 c.603C>A p.S201R Substitution - Missense 38 7:55152655-55152655 + - NEUTRAL .15461 Confirmed somatic variant 539 NS NS ENSP00000395243.3:p.Ser201Arg ENST00000454757.6:c.603C>A 7:g.55152655C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812069 2812069 2668544 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 circulating tumour NS 44 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489245 1489245 1412403 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004989 1004989 922201 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SA213 1659983 1574311 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS y COSV51858303 COSM214296 132592861 c.1024C>G p.L342V Substitution - Missense 38 7:55156784-55156784 + - PATHOGENIC .93843 Confirmed somatic variant 22495314 fresh/frozen - NOS primary 49 ENSP00000395243.3:p.Leu342Val ENST00000454757.6:c.1024C>G 7:g.55156784C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489256 1489256 1412414 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004066-T01-IM5 2720468 2579289 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_C26 1863707 1754598 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 61 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_C26 1863707 1754598 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51777901 COSM1187305 133208703 c.2297C>T p.S766F Substitution - Missense 38 7:55181441-55181441 + - PATHOGENIC .97194 Confirmed somatic variant 22975805 surgery fresh/frozen primary 61 ENSP00000415559.1:p.Ser766Phe ENST00000455089.5:c.2297C>T 7:g.55181441C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EXTERN_MELA_20140524_020 2839454 2695220 skin trunk NS NS malignant_melanoma NS NS NS y COSV104577006 COSM9447599 132574068 c.2996A>G p.N999S Substitution - Missense 38 7:55201751-55201751 + - NEUTRAL .35447 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000395243.3:p.Asn999Ser ENST00000454757.6:c.2996A>G 7:g.55201751A>G TFAP2A_ENST00000379613 ENST00000379613.8 1320 11742 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105902772 COSM10012977 112927873 c.727C>A p.P243T Substitution - Missense 38 6:10404551-10404551 - - PATHOGENIC .96956 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000368933.3:p.Pro243Thr ENST00000379613.8:c.727C>A 6:g.10404551G>T EGFR ENST00000275493.6 3633 3236 2675072 2675072 2534347 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 29110836 surgery-fixed recurrent 65 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2675072 2675072 2534347 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 29110836 surgery-fixed recurrent 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0003702-T02-IM5 2720190 2579011 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51831642 COSM1496684 99388394 c.988G>A p.E330K Substitution - Missense het 38 7:55155928-55155928 + - PATHOGENIC .94538 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Glu330Lys ENST00000275493.6:c.988G>A 7:g.55155928G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000435-T01-IM3 2829184 2684999 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51776947 COSM6910370 133220707 c.2362T>A p.L788M Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .36784 Confirmed somatic variant 30205045 surgery-fixed metastasis 54 ENSP00000415559.1:p.Leu788Met ENST00000455089.5:c.2362T>A 7:g.55191746T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-WS012-T2 2869948 2724945 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110279 COSM9809368 132617537 c.299C>T p.P100L Substitution - Missense 38 7:55143363-55143363 + - PATHOGENIC .96024 Confirmed somatic variant 26950094 surgery - NOS NS 82 ENSP00000395243.3:p.Pro100Leu ENST00000454757.6:c.299C>T 7:g.55143363C>T EGFR ENST00000275493.6 3633 3236 2856502 2856502 2711829 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSM22423 178380012 c.? p.P733S Substitution - Missense + - Confirmed somatic variant 31799787 surgery-fixed NS ENSP00000275493.2:p.Pro733Ser EGFR ENST00000275493.6 3633 3236 2856502 2856502 2711829 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSM9522609 178383134 c.? p.L730F Substitution - Missense + - Confirmed somatic variant 31799787 surgery-fixed NS ENSP00000275493.2:p.Leu730Phe EGFR ENST00000275493.6 3633 3236 P-0006029-T01-IM5 2783109 2640892 prostate NS NS NS carcinoma NS NS NS n COSV51862288 COSM6947601 99418938 c.2734T>G p.S912A Substitution - Missense het 38 7:55198749-55198749 + - PATHOGENIC .906 Confirmed somatic variant 28825054 surgery-fixed metastasis 74 ENSP00000275493.2:p.Ser912Ala ENST00000275493.6:c.2734T>G 7:g.55198749T>G EGFR ENST00000275493.6 3633 3236 3 897182 814805 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV99294040 COSM9120802 133219724 c.379G>A p.A127T Substitution - Missense het 38 7:55143443-55143443 + - NEUTRAL .01752 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000415559.1:p.Ala127Thr ENST00000455089.5:c.379G>A 7:g.55143443G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV51803771 COSM14068 133219764 c.2173G>A p.D725N Substitution - Missense het 38 7:55181317-55181317 + - PATHOGENIC .97623 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000415559.1:p.Asp725Asn ENST00000455089.5:c.2173G>A 7:g.55181317G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV51854311 COSM133198 133219755 c.2108G>A p.R703K Substitution - Missense het 38 7:55174780-55174780 + - PATHOGENIC .99476 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000415559.1:p.Arg703Lys ENST00000455089.5:c.2108G>A 7:g.55174780G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV104368998 COSM9232920 133219743 c.751C>T p.P251S Substitution - Missense het 38 7:55154149-55154149 + - PATHOGENIC .98876 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000415559.1:p.Pro251Ser ENST00000455089.5:c.751C>T 7:g.55154149C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV51776282 COSM1168015 133202278 c.2123C>T p.P708L Substitution - Missense het 38 7:55174795-55174795 + - PATHOGENIC .98745 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000415559.1:p.Pro708Leu ENST00000455089.5:c.2123C>T 7:g.55174795C>T EGFR ENST00000275493.6 3633 3236 2591493 2591493 2452453 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591493 2591493 2452453 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811973 2811973 2668500 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 31534501 pleural effusion metastasis 64 ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001703-T01-IM3 2717826 2576647 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51782832 COSM3881808 133239031 c.604G>A p.D202N Substitution - Missense het 38 7:55152656-55152656 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Asp202Asn ENST00000455089.5:c.604G>A 7:g.55152656G>A COL4A4 ENST00000396625.4 5073 2206 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105883225 COSM10012782 117233490 c.863G>A p.G288E Substitution - Missense 38 2:227103151-227103151 - - PATHOGENIC .94909 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000379866.3:p.Gly288Glu ENST00000396625.4:c.863G>A 2:g.227103151C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0185 2107964 1985825 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774819 COSM35840 132552089 c.1816G>A p.V606M Substitution - Missense 38 7:55173014-55173014 + - PATHOGENIC .99458 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Val606Met ENST00000454757.6:c.1816G>A 7:g.55173014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 117 2748089 2606792 stomach NS NS NS carcinoma NS NS NS y COSV99296699 COSN30690880 133276500 c.3259G>C p.D1087H Substitution - Missense 38 7:55202748-55202748 + - NEUTRAL .05069 Confirmed somatic variant 683 NS primary ENSP00000415559.1:p.Asp1087His ENST00000455089.5:c.3259G>C 7:g.55202748G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460148 1460148 1384025 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CH-LA9 2211435 2079638 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24449147 surgery fresh/frozen NS 51 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211139 1211139 1123007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19381876 surgery fresh/frozen NS 85 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 909LC 2637299 2497672 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26503331 surgery fresh/frozen NS 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211138 1211138 1123006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 85 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005005 1005005 922217 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982879 982879 898598 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G RANBP2 ENST00000283195.10 9675 9848 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105872114 COSM10012893 98436257 c.5568G>T p.E1856D Substitution - Missense 38 2:108766107-108766107 + - PATHOGENIC .84685 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000283195.6:p.Glu1856Asp ENST00000283195.10:c.5568G>T 2:g.108766107G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1505364 1505364 1428242 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51825402 COSM53201 132581510 c.2411A>G p.Q804R Substitution - Missense 38 7:55191795-55191795 + - PATHOGENIC .9858 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000395243.3:p.Gln804Arg ENST00000454757.6:c.2411A>G 7:g.55191795A>G EGFR ENST00000275493.6 3633 3236 GBM15 2144555 2013769 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 24285547 surgery fresh/frozen primary 73 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 132563558 c.2239C>T p.L747F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000395243.3:p.Leu747Phe ENST00000454757.6:c.2239C>T 7:g.55181383C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876034 2876034 2730549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 132563558 c.2239C>T p.L747F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour recurrent 44 ENSP00000395243.3:p.Leu747Phe ENST00000454757.6:c.2239C>T 7:g.55181383C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T2250 2658595 2518754 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51769145 COSM3266559 133241176 c.739G>A p.V247M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 27149842 NS NS 62.08 ENSP00000415559.1:p.Val247Met ENST00000455089.5:c.739G>A 7:g.55154137G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-28-5207 2108065 1985926 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T407 2296247 2161850 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51776282 COSM1168015 132547141 c.2123C>T p.P708L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Confirmed somatic variant 25344691 NS NS 69.16 ENSP00000395243.3:p.Pro708Leu ENST00000454757.6:c.2123C>T 7:g.55174795C>T EGFR ENST00000275493.6 3633 3236 MaPT05 2491636 2354277 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51771223 COSM3929114 99381499 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000275493.2:p.Glu84Val ENST00000275493.6:c.251A>T 7:g.55143315A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876642 2876642 2731157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51789392 COSM3266633 132576637 c.2114C>A p.A705E Substitution - Missense 38 7:55174786-55174786 + - PATHOGENIC .9821 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000395243.3:p.Ala705Glu ENST00000454757.6:c.2114C>A 7:g.55174786C>A EGFR ENST00000275493.6 3633 3236 2812069 2812069 2668544 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 circulating tumour NS 44 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1489245 1489245 1412403 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1004989 1004989 922201 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AD-6964-01 1651148 1565935 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51773844 COSM1451620 132588127 c.3154G>A p.V1052I Substitution - Missense 38 7:55205273-55205273 + - NEUTRAL .13302 Confirmed somatic variant 376 NS NS 58 ENSP00000395243.3:p.Val1052Ile ENST00000454757.6:c.3154G>A 7:g.55205273G>A EGFR ENST00000275493.6 3633 3236 1489256 1489256 1412414 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LC_C26 1863707 1754598 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51777901 COSM1187305 99380481 c.2432C>T p.S811F Substitution - Missense 38 7:55181441-55181441 + - PATHOGENIC .97194 Confirmed somatic variant 22975805 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Ser811Phe ENST00000275493.6:c.2432C>T 7:g.55181441C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006886-T01-IM5 2723266 2582087 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006886-T01-IM5 2723266 2582087 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767386 COSM18423 133220856 c.2365G>T p.V789L Substitution - Missense het 38 7:55191749-55191749 + - PATHOGENIC .9903 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000415559.1:p.Val789Leu ENST00000455089.5:c.2365G>T 7:g.55191749G>T EGFR ENST00000275493.6 3633 3236 LC_C26 1863707 1754598 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009260-T01-IM5 2725217 2584038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51771864 COSM6226 132555722 c.2191C>T p.R731C Substitution - Missense het 38 7:55181335-55181335 + - PATHOGENIC .97187 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg731Cys ENST00000454757.6:c.2191C>T 7:g.55181335C>T EGFR ENST00000275493.6 3633 3236 EXTERN_MELA_20140530_012 2839372 2695138 skin NS NS NS malignant_melanoma NS NS NS y COSV104577175 COSM9448596 99384860 c.3506A>G p.N1169S Substitution - Missense 38 7:55205490-55205490 + - PATHOGENIC .97146 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000275493.2:p.Asn1169Ser ENST00000275493.6:c.3506A>G 7:g.55205490A>G EGFR ENST00000275493.6 3633 3236 1140667 1140667 1053115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26142 178386157 c.? p.G857E Substitution - Missense + - Confirmed somatic variant 19238633 surgery-fixed primary 55 ENSP00000275493.2:p.Gly857Glu EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EXTERN_MELA_20140505_038 2839416 2695182 skin ear NS NS malignant_melanoma NS NS NS y COSV104577055 COSM9446911 132570480 c.752C>T p.P251L Substitution - Missense 38 7:55154150-55154150 + - PATHOGENIC .98876 Confirmed somatic variant 28467829 surgery fresh/frozen recurrent ENSP00000395243.3:p.Pro251Leu ENST00000454757.6:c.752C>T 7:g.55154150C>T EGFR ENST00000275493.6 3633 3236 P-0000435-T01-IM3 2829184 2684999 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51776947 COSM6910370 99393548 c.2497T>A p.L833M Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .36784 Confirmed somatic variant 30205045 surgery-fixed metastasis 54 ENSP00000275493.2:p.Leu833Met ENST00000275493.6:c.2497T>A 7:g.55191746T>A EGFR ENST00000275493.6 3633 3236 P-0005228-T01-IM5 2721631 2580452 skin NS NS NS malignant_melanoma NS NS NS n COSV51814970 COSM6942061 99420537 c.3454G>A p.D1152N Substitution - Missense het 38 7:55205438-55205438 + - .52145 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Asp1152Asn ENST00000275493.6:c.3454G>A 7:g.55205438G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MaPT01s 2491582 2354223 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51775191 COSM1451530 133205080 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000415559.1:p.Gly63Arg ENST00000455089.5:c.187G>A 7:g.55142384G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AX-A0J1-01 1783377 1687376 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99293276 COSM8941767 132573555 c.3323G>A p.S1108N Substitution - Missense 38 7:55205442-55205442 + - NEUTRAL .25647 Confirmed somatic variant 419 fresh/frozen - NOS primary 80 ENSP00000395243.3:p.Ser1108Asn ENST00000454757.6:c.3323G>A 7:g.55205442G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-27-2528-01 1338071 1248456 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 surgery fresh/frozen NS 62 ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV51803771 COSM14068 99392333 c.2308G>A p.D770N Substitution - Missense het 38 7:55181317-55181317 + - PATHOGENIC .97623 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000275493.2:p.Asp770Asn ENST00000275493.6:c.2308G>A 7:g.55181317G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-WE-AAA4-06 2339475 2204458 skin NS NS NS malignant_melanoma NS NS NS y COSV99286479 COSM8046349 132564639 c.1255T>C p.S419P Substitution - Missense 38 7:55160230-55160230 + - PATHOGENIC .73545 Confirmed somatic variant 540 NS NS 56 ENSP00000395243.3:p.Ser419Pro ENST00000454757.6:c.1255T>C 7:g.55160230T>C EGFR ENST00000275493.6 3633 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV99294040 COSM9120802 99392184 c.379G>A p.A127T Substitution - Missense het 38 7:55143443-55143443 + - NEUTRAL .01752 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000275493.2:p.Ala127Thr ENST00000275493.6:c.379G>A 7:g.55143443G>A EGFR ENST00000275493.6 3633 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV51854311 COSM133198 99392224 c.2243G>A p.R748K Substitution - Missense het 38 7:55174780-55174780 + - PATHOGENIC .99476 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000275493.2:p.Arg748Lys ENST00000275493.6:c.2243G>A 7:g.55174780G>A EGFR ENST00000275493.6 3633 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV104368998 COSM9232920 99392201 c.886C>T p.P296S Substitution - Missense het 38 7:55154149-55154149 + - PATHOGENIC .98876 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000275493.2:p.Pro296Ser ENST00000275493.6:c.886C>T 7:g.55154149C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006151-T01-IM5 2722529 2581350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV51776282 COSM1168015 99373518 c.2258C>T p.P753L Substitution - Missense het 38 7:55174795-55174795 + - PATHOGENIC .98745 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000275493.2:p.Pro753Leu ENST00000275493.6:c.2258C>T 7:g.55174795C>T EGFR ENST00000275493.6 3633 3236 2811973 2811973 2668500 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 31534501 pleural effusion metastasis 64 ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 133216269 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2254T>A 7:g.55181398T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 133219834 c.2239C>T p.L747F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000415559.1:p.Leu747Phe ENST00000455089.5:c.2239C>T 7:g.55181383C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 133219858 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2255G>C 7:g.55181399G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 133203473 c.2117C>T p.T706I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000415559.1:p.Thr706Ile ENST00000455089.5:c.2117C>T 7:g.55174789C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 133213822 c.2018T>A p.L673Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000415559.1:p.Leu673Gln ENST00000455089.5:c.2018T>A 7:g.55174012T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 133219841 c.2240T>A p.L747H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000415559.1:p.Leu747His ENST00000455089.5:c.2240T>A 7:g.55181384T>A EGFR ENST00000275493.6 3633 3236 P-0001703-T01-IM3 2717826 2576647 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51782832 COSM3881808 99412645 c.739G>A p.D247N Substitution - Missense het 38 7:55152656-55152656 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Asp247Asn ENST00000275493.6:c.739G>A 7:g.55152656G>A EGFR ENST00000275493.6 3633 3236 92177 2807582 2664283 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99293495 COSM9130691 99451267 c.535G>A p.D179N Substitution - Missense 38 7:55146716-55146716 + - PATHOGENIC .99452 Confirmed somatic variant 24807215 surgery fresh/frozen primary 45 ENSP00000275493.2:p.Asp179Asn ENST00000275493.6:c.535G>A 7:g.55146716G>A EGFR ENST00000275493.6 3633 3236 945813 945813 862339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 16144918 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AD-6964-01 1651148 1565935 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51806191 COSM1451618 132588121 c.2959A>T p.T987S Substitution - Missense 38 7:55201335-55201335 + - PATHOGENIC .99325 Confirmed somatic variant 376 NS NS 58 ENSP00000395243.3:p.Thr987Ser ENST00000454757.6:c.2959A>T 7:g.55201335A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MaPT19 2491650 2354291 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 T2250 2658595 2518754 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51769145 COSM3266559 99415380 c.874G>A p.V292M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 27149842 NS NS 62.08 ENSP00000275493.2:p.Val292Met ENST00000275493.6:c.874G>A 7:g.55154137G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-14-1456 2108037 1985898 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460108 1460108 1383985 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 133203473 c.2117C>T p.T706I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000415559.1:p.Thr706Ile ENST00000455089.5:c.2117C>T 7:g.55174789C>T EGFR ENST00000275493.6 3633 3236 1312380 1312380 1223289 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0006886-T01-IM5 2723266 2582087 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767386 COSM18423 99393803 c.2500G>T p.V834L Substitution - Missense het 38 7:55191749-55191749 + - PATHOGENIC .9903 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000275493.2:p.Val834Leu ENST00000275493.6:c.2500G>T 7:g.55191749G>T EGFR ENST00000275493.6 3633 3236 P-0006886-T01-IM5 2723266 2582087 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458686 1458686 1382661 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_S24 1863735 1754626 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982776 982776 898495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982776 982776 898495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 I2L-P16-Tumor-Biopsy 2433478 2296359 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51814923 COSM5358036 99380300 c.559T>C p.C187R Substitution - Missense het 38 7:55146740-55146740 + - PATHOGENIC .98691 Confirmed somatic variant 25957691 NS NS 67 ENSP00000275493.2:p.Cys187Arg ENST00000275493.6:c.559T>C 7:g.55146740T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010340-T01-IM5 2726107 2584928 NS NS NS NS malignant_melanoma NS NS NS n COSV51799199 COSM1251020 132553945 c.1639G>A p.V547I Substitution - Missense het 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Val547Ile ENST00000454757.6:c.1639G>A 7:g.55165331G>A EGFR ENST00000275493.6 3633 3236 MaPT01s 2491582 2354223 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51775191 COSM1451530 99377057 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000275493.2:p.Gly63Arg ENST00000275493.6:c.187G>A 7:g.55142384G>A EGFR ENST00000275493.6 3633 3236 P-0006151-T01-IM5 2722529 2581350 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 99385331 c.2153T>A p.L718Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000275493.2:p.Leu718Gln ENST00000275493.6:c.2153T>A 7:g.55174012T>A EGFR ENST00000275493.6 3633 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 99392449 c.2374C>T p.L792F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000275493.2:p.Leu792Phe ENST00000275493.6:c.2374C>T 7:g.55181383C>T EGFR ENST00000275493.6 3633 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 99388191 c.2389T>A p.C797S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2389T>A 7:g.55181398T>A EGFR ENST00000275493.6 3633 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 99392455 c.2375T>A p.L792H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000275493.2:p.Leu792His ENST00000275493.6:c.2375T>A 7:g.55181384T>A EGFR ENST00000275493.6 3633 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 99392475 c.2390G>C p.C797S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2390G>C 7:g.55181399G>C EGFR ENST00000275493.6 3633 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 99375118 c.2252C>T p.T751I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000275493.2:p.Thr751Ile ENST00000275493.6:c.2252C>T 7:g.55174789C>T EGFR ENST00000275493.6 3633 3236 2876037 2876037 2730552 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 62 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T KCNK2 ENST00000444842.6 1281 6277 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105930970 COSM10012965 129958994 c.276G>T p.R92S Substitution - Missense 38 1:215086597-215086597 + - PATHOGENIC .96743 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000394033.2:p.Arg92Ser ENST00000444842.6:c.276G>T 1:g.215086597G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011540-T01-IM5 2727112 2585933 small_intestine ileum NS NS carcinoma adenocarcinoma NS NS n COSV51797215 COSM145360 132558158 c.832G>A p.V278I Substitution - Missense het 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Val278Ile ENST00000454757.6:c.832G>A 7:g.55155907G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-5856-01 2120270 1994506 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 58 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-6700-01 2120280 1994516 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772666 COSM3412205 132552119 c.2812G>A p.G938R Substitution - Missense 38 7:55201188-55201188 + - PATHOGENIC .98883 Confirmed somatic variant 329 NS NS 76 ENSP00000395243.3:p.Gly938Arg ENST00000454757.6:c.2812G>A 7:g.55201188G>A EGFR ENST00000275493.6 3633 3236 2308796 2308796 2173999 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM34167 178379046 c.? p.G598V Substitution - Missense + - Confirmed somatic variant 24510240 surgery - NOS NS ENSP00000275493.2:p.Gly598Val EGFR ENST00000275493.6 3633 3236 2115507 2115507 1989751 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-14-1823-01 1338013 1248398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 58 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001303-T02-IM3 2717028 2575849 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001303-T02-IM3 2717028 2575849 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51807743 COSM133179 133222581 c.1930G>A p.V644M Substitution - Missense het 38 7:55173924-55173924 + - PATHOGENIC .9843 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Val644Met ENST00000455089.5:c.1930G>A 7:g.55173924G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009873-T01-IM5 2725712 2584533 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 TCGA-14-1456 2108037 1985898 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-QC-A7B5-01 2270128 2136896 soft_tissue NS NS NS sarcoma NS NS NS y COSV51772347 COSM17570 132552045 c.2087C>T p.P696L Substitution - Missense 38 7:55174759-55174759 + - PATHOGENIC .9905 Confirmed somatic variant 635 NS NS ENSP00000395243.3:p.Pro696Leu ENST00000454757.6:c.2087C>T 7:g.55174759C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001255 1001255 918478 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1460108 1460108 1383985 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773111 COSM13185 99375118 c.2252C>T p.T751I Substitution - Missense 38 7:55174789-55174789 + - PATHOGENIC .99151 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000275493.2:p.Thr751Ile ENST00000275493.6:c.2252C>T 7:g.55174789C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-RSII 2060462 1940669 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma Richter_transformation NS y COSV51773206 COSM28603 132560955 c.2158G>A p.V720M Substitution - Missense 38 7:55181302-55181302 + - PATHOGENIC .97963 Confirmed somatic variant 24127483 blood-bone marrow primary 70 ENSP00000395243.3:p.Val720Met ENST00000454757.6:c.2158G>A 7:g.55181302G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A014-T-S08 2758132 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2861856 2861856 2717072 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM9571894 178388896 c.? p.V851A Substitution - Missense + - Confirmed somatic variant 31548343 circulating tumour NS ENSP00000275493.2:p.Val851Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0125 2107938 1985799 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002026-T01-IM3 2718333 2577154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1486990 1486990 1410608 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51849884 COSM13192 133211467 c.2293G>A p.G765S Substitution - Missense 38 7:55181437-55181437 + - PATHOGENIC .98229 Confirmed somatic variant 16567021 surgery-fixed primary 68 ENSP00000415559.1:p.Gly765Ser ENST00000455089.5:c.2293G>A 7:g.55181437G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1486990 1486990 1410608 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51767182 COSM27110 133210338 c.2221G>A p.V741M Substitution - Missense 38 7:55181365-55181365 + - PATHOGENIC .97319 Confirmed somatic variant 16567021 surgery-fixed primary 68 ENSP00000415559.1:p.Val741Met ENST00000455089.5:c.2221G>A 7:g.55181365G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001278-T01-IM3 2716974 2575795 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51844468 COSM6916179 132568052 c.308A>T p.N103I Substitution - Missense het 38 7:55143372-55143372 + - PATHOGENIC .97828 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Asn103Ile ENST00000454757.6:c.308A>T 7:g.55143372A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 100641 1520659 1443034 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20668451 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-43-A56U-01 2195058 2063336 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99290842 COSM8713904 132603893 c.440C>G p.P147R Substitution - Missense 38 7:55151309-55151309 + - PATHOGENIC .9684 Confirmed somatic variant 418 NS NS 76 ENSP00000395243.3:p.Pro147Arg ENST00000454757.6:c.440C>G 7:g.55151309C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-93-A4JP-01 2385674 2248506 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 417 NS primary 64 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008179-T01-IM5 2724346 2583167 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 132553945 c.1639G>A p.V547I Substitution - Missense het 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Val547Ile ENST00000454757.6:c.1639G>A 7:g.55165331G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005148-T01-IM5 2721554 2580375 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005148-T01-IM5 2721554 2580375 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1109740 1109740 1023650 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 47 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G GFOD1 ENST00000379287.3 1173 21096 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV64954773 COSM6670542 116097065 c.1120G>A p.A374T Substitution - Missense 38 6:13364796-13364796 - - PATHOGENIC .98237 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000368589.3:p.Ala374Thr ENST00000379287.3:c.1120G>A 6:g.13364796C>T CD1B ENST00000368168.3 1002 1635 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105921969 COSM10012934 110451901 c.530G>T p.R177I Substitution - Missense 38 1:158329929-158329929 - - NEUTRAL .01311 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000357150.3:p.Arg177Ile ENST00000368168.3:c.530G>T 1:g.158329929C>A EGFR ENST00000275493.6 3633 3236 TCGA-06-5856-01 2120270 1994506 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 58 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 TCGA-14-1823-01 1338013 1248398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 58 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 P-0001303-T02-IM3 2717028 2575849 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51807743 COSM133179 99396505 c.2065G>A p.V689M Substitution - Missense het 38 7:55173924-55173924 + - PATHOGENIC .9843 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Val689Met ENST00000275493.6:c.2065G>A 7:g.55173924G>A EGFR ENST00000275493.6 3633 3236 P-0001303-T02-IM3 2717028 2575849 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 05-123E2 2575154 2436491 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51804536 COSM5997191 99406675 c.3304G>A p.A1102T Substitution - Missense 38 7:55205288-55205288 + - NEUTRAL .17823 Confirmed somatic variant 26928463 autopsy - NOS metastasis 80 ENSP00000275493.2:p.Ala1102Thr ENST00000275493.6:c.3304G>A 7:g.55205288G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1595808 1595808 1516605 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51793896 COSM22954 133217512 c.2189G>A p.C730Y Substitution - Missense hom 38 7:55181333-55181333 + - PATHOGENIC .97278 Confirmed somatic variant 16551849 surgery-fixed NS 70 ENSP00000415559.1:p.Cys730Tyr ENST00000455089.5:c.2189G>A 7:g.55181333G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 112707 1520735 1443110 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20668451 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206739 1206739 1118617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206739 1206739 1118617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51854030 COSM29578 133214199 c.2438T>A p.L813Q Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .9803 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Leu813Gln ENST00000455089.5:c.2438T>A 7:g.55191822T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206739 1206739 1118617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206739 1206739 1118617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-GM-A2DD-01 2187736 2056014 breast NS NS NS carcinoma NS NS NS y COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 414 NS NS 53 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1001255 1001255 918478 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 61 2497169 2359521 small_intestine duodenum NS NS adenoma NS NS NS y COSV51766928 COSM12718 132551704 c.2045A>G p.Y682C Substitution - Missense 38 7:55174039-55174039 + - PATHOGENIC .97626 Confirmed somatic variant 26806338 fresh/frozen - NOS primary ENSP00000395243.3:p.Tyr682Cys ENST00000454757.6:c.2045A>G 7:g.55174039A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002999-T01-IM3 2783044 2640827 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 132555528 c.620G>A p.R207H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28825054 surgery-fixed primary 57 ENSP00000395243.3:p.Arg207His ENST00000454757.6:c.620G>A 7:g.55154018G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 082 1630826 1547696 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51769737 COSM145359 132583523 c.3367G>A p.D1123N Substitution - Missense 38 7:55205486-55205486 + - PATHOGENIC .97139 Confirmed somatic variant 22158541 blood-bone marrow NS ENSP00000395243.3:p.Asp1123Asn ENST00000454757.6:c.3367G>A 7:g.55205486G>A EGFR ENST00000275493.6 3633 3236 A014-T-S08 2758132 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152699 2152699 2021709 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P146 2072599 1951954 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 48 ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914587 914587 832036 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 49 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471561 1471561 1395300 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1486990 1486990 1410608 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51767182 COSM27110 99381953 c.2356G>A p.V786M Substitution - Missense 38 7:55181365-55181365 + - PATHOGENIC .97319 Confirmed somatic variant 16567021 surgery-fixed primary 68 ENSP00000275493.2:p.Val786Met ENST00000275493.6:c.2356G>A 7:g.55181365G>A EGFR ENST00000275493.6 3633 3236 1486990 1486990 1410608 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51849884 COSM13192 99382863 c.2428G>A p.G810S Substitution - Missense 38 7:55181437-55181437 + - PATHOGENIC .98229 Confirmed somatic variant 16567021 surgery-fixed primary 68 ENSP00000275493.2:p.Gly810Ser ENST00000275493.6:c.2428G>A 7:g.55181437G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000609-T01-IM3 2715617 2574438 soft_tissue fibrous_tissue_and_uncertain_origin NS NS desmoplastic_small_round_cell_tumour NS NS NS n COSV51861952 COSM6911610 133224390 c.2776A>G p.M926V Substitution - Missense het 38 7:55200378-55200378 + - PATHOGENIC .99305 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Met926Val ENST00000455089.5:c.2776A>G 7:g.55200378A>G EGFR ENST00000275493.6 3633 3236 315-14 2605258 2466149 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Confirmed somatic variant 25376516 surgery - NOS NS 67 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 TCGA-06-0125 2107938 1985799 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 OSCC-GB_00550111 2340760 2205743 upper_aerodigestive_tract mouth NS NS carcinoma NS NS NS y COSV51836185 COSM4884832 132575704 c.604G>T p.D202Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 539 NS primary 58 ENSP00000395243.3:p.Asp202Tyr ENST00000454757.6:c.604G>T 7:g.55152656G>T EGFR ENST00000275493.6 3633 3236 P-0002026-T01-IM3 2718333 2577154 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 TCGA-93-A4JP-01 2385674 2248506 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 417 NS primary 64 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 100641 1520659 1443034 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20668451 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1312396 1312396 1223305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 71 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1040350 1040350 956927 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_II NS NS n COSV51790148 COSM22555 133209794 c.1895G>A p.R632H Substitution - Missense 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000415559.1:p.Arg632His ENST00000455089.5:c.1895G>A 7:g.55173093G>A EGFR ENST00000275493.6 3633 3236 P-0005148-T01-IM5 2721554 2580375 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0005148-T01-IM5 2721554 2580375 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1109740 1109740 1023650 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 47 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005013 1005013 922225 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DF-A2KN-01 2457388 2320225 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99289848 COSM9047248 133217720 c.923C>T p.A308V Substitution - Missense 38 7:55156584-55156584 + - PATHOGENIC .99015 Confirmed somatic variant 419 NS primary ENSP00000415559.1:p.Ala308Val ENST00000455089.5:c.923C>T 7:g.55156584C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801711 COSM3923810 132593012 c.772G>A p.D258N Substitution - Missense 38 7:55155847-55155847 + - PATHOGENIC .99324 Confirmed somatic variant 540 NS NS 68 ENSP00000395243.3:p.Asp258Asn ENST00000454757.6:c.772G>A 7:g.55155847G>A EGFR ENST00000275493.6 3633 3236 1468563 1468563 1392314 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 1468563 1468563 1392314 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM53180 178383586 c.? p.G873E Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Gly873Glu KIAA1328 ENST00000280020.9 1734 29248 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV54469129 COSM2811627 101584129 c.1655C>T p.T552I Substitution - Missense 38 18:37222148-37222148 + - NEUTRAL .10669 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000280020.5:p.Thr552Ile ENST00000280020.9:c.1655C>T 18:g.37222148C>T EGFR ENST00000275493.6 3633 3236 1516693 1516693 1439287 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21575252 surgery - NOS NS 47 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 112707 1520735 1443110 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20668451 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206739 1206739 1118617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51854030 COSM29578 99385738 c.2573T>A p.L858Q Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .9803 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Leu858Gln ENST00000275493.6:c.2573T>A 7:g.55191822T>A EGFR ENST00000275493.6 3633 3236 1206739 1206739 1118617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1206739 1206739 1118617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206739 1206739 1118617 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 618 1630888 1547758 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51797215 COSM145360 132558158 c.832G>A p.V278I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 22158541 blood-bone marrow NS ENSP00000395243.3:p.Val278Ile ENST00000454757.6:c.832G>A 7:g.55155907G>A EGFR ENST00000275493.6 3633 3236 945806 945806 862332 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 16144918 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1489230 1489230 1412388 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830809 COSM85993 99415063 c.2260A>G p.K754E Substitution - Missense 38 7:55174797-55174797 + - PATHOGENIC .99211 Confirmed somatic variant 20881644 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Lys754Glu ENST00000275493.6:c.2260A>G 7:g.55174797A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FG-A70Z-01 2194226 2062504 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 53 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876034 2876034 2730549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832145 COSM6493936 132574809 c.2254T>G p.C752G Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95801 Confirmed somatic variant 29506987 circulating tumour recurrent 44 ENSP00000395243.3:p.Cys752Gly ENST00000454757.6:c.2254T>G 7:g.55181398T>G EGFR ENST00000275493.6 3633 3236 MaPT19 2491650 2354291 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 P146 2072599 1951954 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 48 ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD4604a 1356528 1266569 breast NS NS NS carcinoma lobular_carcinoma NS NS y COSV51822879 COSM4680399 133211230 c.1904G>A p.R635Q Substitution - Missense 38 7:55173102-55173102 + - PATHOGENIC .99814 Confirmed somatic variant 652 NS primary ENSP00000415559.1:p.Arg635Gln ENST00000455089.5:c.1904G>A 7:g.55173102G>A EGFR ENST00000275493.6 3633 3236 P-0000609-T01-IM3 2715617 2574438 soft_tissue fibrous_tissue_and_uncertain_origin NS NS desmoplastic_small_round_cell_tumour NS NS NS n COSV51861952 COSM6911610 99399282 c.2911A>G p.M971V Substitution - Missense het 38 7:55200378-55200378 + - PATHOGENIC .99305 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Met971Val ENST00000275493.6:c.2911A>G 7:g.55200378A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1040349 1040349 956926 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_II NS NS n COSV51790148 COSM22555 132554437 c.1895G>A p.R632H Substitution - Missense 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000395243.3:p.Arg632His ENST00000454757.6:c.1895G>A 7:g.55173093G>A EGFR ENST00000275493.6 3633 3236 1040350 1040350 956927 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_II NS NS n COSV51790148 COSM22555 99381470 c.2030G>A p.R677H Substitution - Missense 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000275493.2:p.Arg677His ENST00000275493.6:c.2030G>A 7:g.55173093G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002490-T01-IM3 2718762 2577583 NS NS NS NS malignant_melanoma NS NS NS n COSV51822498 COSM3266565 133238887 c.782C>T p.S261L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ser261Leu ENST00000455089.5:c.782C>T 7:g.55155857C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002490-T01-IM3 2718762 2577583 NS NS NS NS malignant_melanoma NS NS NS n COSV51822525 COSM6922832 133242841 c.1205C>T p.S402F Substitution - Missense het 38 7:55160180-55160180 + - .61329 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ser402Phe ENST00000455089.5:c.1205C>T 7:g.55160180C>T EGFR ENST00000275493.6 3633 3236 1091708 1091708 1006530 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26139 178391288 c.? p.L703F Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011389-T01-IM5 2726985 2585806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011389-T01-IM5 2726985 2585806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM19-I3 2813467 2669859 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 1005013 1005013 922225 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 61 2497169 2359521 small_intestine duodenum NS NS adenoma NS NS NS y COSV51766928 COSM12718 99378527 c.2180A>G p.Y727C Substitution - Missense 38 7:55174039-55174039 + - PATHOGENIC .97626 Confirmed somatic variant 26806338 fresh/frozen - NOS primary ENSP00000275493.2:p.Tyr727Cys ENST00000275493.6:c.2180A>G 7:g.55174039A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011540-T01-IM5 2727112 2585933 small_intestine ileum NS NS carcinoma adenocarcinoma NS NS n COSV51797215 COSM145360 133214261 c.832G>A p.V278I Substitution - Missense het 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Val278Ile ENST00000455089.5:c.832G>A 7:g.55155907G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DI-A1BU-01 2198300 2066578 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99287857 COSM9051280 132571221 c.3146A>G p.N1049S Substitution - Missense 38 7:55205265-55205265 + - PATHOGENIC .98005 Confirmed somatic variant 419 NS NS 55 ENSP00000395243.3:p.Asn1049Ser ENST00000454757.6:c.3146A>G 7:g.55205265A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CRC334 2730827 2589596 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51767379 COSM85894 132557468 c.2392G>A p.V798I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 26416732 xenograft metastasis 65 ENSP00000395243.3:p.Val798Ile ENST00000454757.6:c.2392G>A 7:g.55191776G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004328-T01-IM5 2720736 2579557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2492720 2492720 2355335 skin ear NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 133212507 c.2890G>A p.D964N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 26286987 surgery fresh/frozen primary ENSP00000415559.1:p.Asp964Asn ENST00000455089.5:c.2890G>A 7:g.55201266G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2749050 2749050 2607753 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS n COSV51827262 COSM53226 132561394 c.1964A>G p.N655S Substitution - Missense 38 7:55173958-55173958 + - PATHOGENIC .97158 Confirmed somatic variant 29360550 surgery-fixed NS 69 ENSP00000395243.3:p.Asn655Ser ENST00000454757.6:c.1964A>G 7:g.55173958A>G EGFR ENST00000275493.6 3633 3236 TCGA-DF-A2KN-01 2457388 2320225 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99289848 COSM9047248 99389973 c.1058C>T p.A353V Substitution - Missense 38 7:55156584-55156584 + - PATHOGENIC .99015 Confirmed somatic variant 419 NS primary ENSP00000275493.2:p.Ala353Val ENST00000275493.6:c.1058C>T 7:g.55156584C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876624 2876624 2731139 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 29506987 surgery-fixed NS 48 ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 1054309 1054309 970380 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 17409862 surgery - NOS primary 72 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2492720 2492720 2355335 skin ear NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 99383908 c.3025G>A p.D1009N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 26286987 surgery fresh/frozen primary ENSP00000275493.2:p.Asp1009Asn ENST00000275493.6:c.3025G>A 7:g.55201266G>A EGFR ENST00000275493.6 3633 3236 TCGA-FG-A70Z-01 2194226 2062504 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 53 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2591395 2591395 2452355 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591395 2591395 2452355 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876618 2876618 2731133 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + Yes PATHOGENIC .98253 Confirmed somatic variant 29506987 circulating tumour NS 60 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876618 2876618 2731133 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 29506987 circulating tumour NS 60 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002614-T02-IM5 2719521 2578342 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002614-T02-IM5 2719521 2578342 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense het 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801732 COSM3923812 132593019 c.956C>T p.S319F Substitution - Missense 38 7:55156617-55156617 + - NEUTRAL .433 Confirmed somatic variant 540 NS NS 68 ENSP00000395243.3:p.Ser319Phe ENST00000454757.6:c.956C>T 7:g.55156617C>T EGFR ENST00000275493.6 3633 3236 TCGA-HT-8107-01 2194409 2062687 central_nervous_system brain NS NS glioma NS NS NS y COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 545 NS NS 62 ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 S001076 1027683 944659 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 P-0002490-T01-IM3 2718762 2577583 NS NS NS NS malignant_melanoma NS NS NS n COSV51822498 COSM3266565 99412489 c.917C>T p.S306L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ser306Leu ENST00000275493.6:c.917C>T 7:g.55155857C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-RSII 2060462 1940669 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma Richter_transformation NS y COSV51773206 COSM28603 133217070 c.2158G>A p.V720M Substitution - Missense 38 7:55181302-55181302 + - PATHOGENIC .97963 Confirmed somatic variant 24127483 blood-bone marrow primary 70 ENSP00000415559.1:p.Val720Met ENST00000455089.5:c.2158G>A 7:g.55181302G>A EGFR ENST00000275493.6 3633 3236 1312379 1312379 1223288 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 46 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 P-0002490-T01-IM3 2718762 2577583 NS NS NS NS malignant_melanoma NS NS NS n COSV51822525 COSM6922832 99417488 c.1340C>T p.S447F Substitution - Missense het 38 7:55160180-55160180 + - .61329 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ser447Phe ENST00000275493.6:c.1340C>T 7:g.55160180C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1589270 1589270 1510424 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51782403 COSM22951 133242202 c.2249T>C p.F750S Substitution - Missense 38 7:55181393-55181393 + - .67484 Confirmed somatic variant 22026926 surgery fresh/frozen NS ENSP00000415559.1:p.Phe750Ser ENST00000455089.5:c.2249T>C 7:g.55181393T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1044280 1044280 960621 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 41 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A114-T-S23 2757426 2616005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 61 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 Br02X 1312964 1223873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 xenograft primary 39 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766880 COSM28516 132563580 c.2269G>T p.V757F Substitution - Missense 38 7:55181413-55181413 + - PATHOGENIC .89385 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000395243.3:p.Val757Phe ENST00000454757.6:c.2269G>T 7:g.55181413G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982877 982877 898596 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010337-T01-IM5 2726104 2584925 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004066-T01-IM5 2720468 2579289 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152773 2152773 2021783 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A021-T-S02 2757379 2615995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 57 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2028217 2028217 1910119 thymus NS NS NS thymoma NS NS NS n COSM23617 178385408 c.? p.T785I Substitution - Missense + - Confirmed somatic variant 23765114 surgery - NOS NS ENSP00000275493.2:p.Thr785Ile ACACB_ENST00000377848 ENST00000377848.7 7377 85 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105910389 COSM10012924 115770081 c.863G>A p.R288H Substitution - Missense 38 12:109167972-109167972 + - PATHOGENIC .98749 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000367079.3:p.Arg288His ENST00000377848.7:c.863G>A 12:g.109167972G>A EGFR ENST00000275493.6 3633 3236 P-0011389-T01-IM5 2726985 2585806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 P-0011389-T01-IM5 2726985 2585806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 GBM19-I3 2813467 2669859 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1322265 1322265 1233152 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51788393 COSM13979 133219516 c.2035G>A p.G679S Substitution - Missense 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 19844187 surgery-fixed primary 52 ENSP00000415559.1:p.Gly679Ser ENST00000455089.5:c.2035G>A 7:g.55174029G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1179550 1179550 1091512 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004379-T01-IM5 2720790 2579611 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51857819 COSM6935325 132563378 c.1262A>C p.N421T Substitution - Missense het 38 7:55160237-55160237 + - PATHOGENIC .99346 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Asn421Thr ENST00000454757.6:c.1262A>C 7:g.55160237A>C EGFR ENST00000275493.6 3633 3236 CC28 2856039 2711440 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSM9516328 178384249 c.? p.D807E Substitution - Missense + - Confirmed somatic variant 29665843 surgery fresh/frozen NS 56 ENSP00000275493.2:p.Asp807Glu EGFR ENST00000275493.6 3633 3236 2876618 2876618 2731133 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 29506987 circulating tumour NS 60 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2876618 2876618 2731133 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + Yes PATHOGENIC .98253 Confirmed somatic variant 29506987 circulating tumour NS 60 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 P-0002614-T02-IM5 2719521 2578342 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense het 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 P-0002614-T02-IM5 2719521 2578342 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1589270 1589270 1510424 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51782403 COSM22951 99416657 c.2384T>C p.F795S Substitution - Missense 38 7:55181393-55181393 + - .67484 Confirmed somatic variant 22026926 surgery fresh/frozen NS ENSP00000275493.2:p.Phe795Ser ENST00000275493.6:c.2384T>C 7:g.55181393T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AD-6964-01 1651148 1565935 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51806191 COSM1451618 133249771 c.2959A>T p.T987S Substitution - Missense 38 7:55201335-55201335 + - PATHOGENIC .99325 Confirmed somatic variant 376 NS NS 58 ENSP00000415559.1:p.Thr987Ser ENST00000455089.5:c.2959A>T 7:g.55201335A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CTS131 2393051 2255882 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 945816 945816 862342 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 16144918 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468641 1468641 1392392 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A8 2409506 2272386 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25112956 surgery fresh/frozen NS 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1322265 1322265 1233152 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51788393 COSM13979 99391974 c.2170G>A p.G724S Substitution - Missense 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 19844187 surgery-fixed primary 52 ENSP00000275493.2:p.Gly724Ser ENST00000275493.6:c.2170G>A 7:g.55174029G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002695-T01-IM3 2718937 2577758 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51788017 COSM6923954 133282467 c.3127C>T p.P1043S Substitution - Missense het 38 7:55202616-55202616 + - PATHOGENIC .96386 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Pro1043Ser ENST00000455089.5:c.3127C>T 7:g.55202616C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876601 2876601 2731116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 surgery fresh/frozen NS 50 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876601 2876601 2731116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 133216269 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 surgery fresh/frozen NS 50 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2254T>A 7:g.55181398T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876601 2876601 2731116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 surgery fresh/frozen NS 50 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458681 1458681 1382656 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FG-A4MW-01 2194412 2062690 central_nervous_system brain NS NS glioma NS NS NS y COSV51814881 COSM3929116 133224708 c.799G>T p.G267W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 545 NS NS 63 ENSP00000415559.1:p.Gly267Trp ENST00000455089.5:c.799G>T 7:g.55155874G>T EGFR ENST00000275493.6 3633 3236 1179550 1179550 1091512 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MBC_61 2662766 2522890 breast NS NS NS carcinoma ER-PR-positive_carcinoma NS NS y COSV51771306 COSM1318972 133218950 c.1778C>T p.T593M Substitution - Missense 38 7:55171207-55171207 + - NEUTRAL .03249 Confirmed somatic variant 28027327 fresh/frozen - NOS NS ENSP00000415559.1:p.Thr593Met ENST00000455089.5:c.1778C>T 7:g.55171207C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152762 2152762 2021772 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 315-14 2605258 2466149 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 25376516 surgery - NOS NS 67 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1031893 1031893 948684 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 132565801 c.2146G>T p.D716Y Substitution - Missense het 38 7:55174818-55174818 + Yes PATHOGENIC .99554 Confirmed somatic variant 17085664 NS metastasis 72 ENSP00000395243.3:p.Asp716Tyr ENST00000454757.6:c.2146G>T 7:g.55174818G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000630-T01-IM3 2715664 2574485 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000630-T01-IM3 2715664 2574485 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 HUB-02-B2-074 2607124 2466836 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51839532 COSM6040570 132554338 c.3178G>A p.V1060M Substitution - Missense 38 7:55205297-55205297 + - .69731 Confirmed somatic variant 670 organoid culture NS ENSP00000395243.3:p.Val1060Met ENST00000454757.6:c.3178G>A 7:g.55205297G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-02-2466-01 2178184 2046482 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 61 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007580-T01-IM5 2723865 2582686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780206 COSM12373 133208468 c.2024C>T p.S675F Substitution - Missense het 38 7:55174018-55174018 + - PATHOGENIC .9768 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ser675Phe ENST00000455089.5:c.2024C>T 7:g.55174018C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007580-T01-IM5 2723865 2582686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001254 1001254 918477 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 PD42114a 2894823 2749311 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV105111067 COSM9915039 99459887 c.3098C>T p.P1033L Substitution - Missense 38 7:55201339-55201339 + - PATHOGENIC .98608 Confirmed somatic variant 33024263 surgery-fixed metastasis 54 ENSP00000275493.2:p.Pro1033Leu ENST00000275493.6:c.3098C>T 7:g.55201339C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982879 982879 898598 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211139 1211139 1123007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19381876 surgery fresh/frozen NS 85 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005005 1005005 922217 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 909LC 2637299 2497672 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26503331 surgery fresh/frozen NS 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211138 1211138 1123006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 85 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CH-LA9 2211435 2079638 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24449147 surgery fresh/frozen NS 51 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460148 1460148 1384025 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 785-1836-01TD 1921510 1808828 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51777546 COSN19120084 133208903 c.3148G>T p.V1050F Substitution - Missense 38 7:55202637-55202637 + - NEUTRAL .0304 Confirmed somatic variant 340 blood NS ENSP00000415559.1:p.Val1050Phe ENST00000455089.5:c.3148G>T 7:g.55202637G>T EGFR ENST00000275493.6 3633 3236 P-0017699-T01-IM6 2830937 2686752 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51837290 COSM6921325 99396647 c.3335A>G p.N1112S Substitution - Missense 38 7:55205319-55205319 + - PATHOGENIC .95172 Confirmed somatic variant 30205045 surgery-fixed primary 38 ENSP00000275493.2:p.Asn1112Ser ENST00000275493.6:c.3335A>G 7:g.55205319A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5 897197 814820 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876046 2876046 2730561 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 52 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0007084-T02-IM5 2723457 2582278 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51797839 COSM6958991 99414799 c.37G>A p.A13T Substitution - Missense het 38 7:55019314-55019314 + - NEUTRAL .01885 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ala13Thr ENST00000275493.6:c.37G>A 7:g.55019314G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982790 982790 898509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BR-8680-01 2197966 2066244 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51785413 COSM1176673 132555528 c.620G>A p.R207H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 541 NS NS 45 ENSP00000395243.3:p.Arg207His ENST00000454757.6:c.620G>A 7:g.55154018G>A EGFR ENST00000275493.6 3633 3236 CTS131 2393051 2255882 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BA-4075-01 2193631 2061909 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99292704 COSM8332917 133230517 c.1502C>A p.P501Q Substitution - Missense 38 7:55163738-55163738 + - PATHOGENIC .97378 Confirmed somatic variant 627 NS NS 49 ENSP00000415559.1:p.Pro501Gln ENST00000455089.5:c.1502C>A 7:g.55163738C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2665864 2665864 2525572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792237 COSM6842523 132558035 c.694_695delinsGA p.M232E Substitution - Missense het 38 7:55154092-55154093 + - Confirmed somatic variant 28979142 surgery - NOS NS 70 ENSP00000395243.3:p.Met232Glu ENST00000454757.6:c.694_695delinsGA 7:g.55154092_55154093delinsGA EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008179-T02-IM5 2830115 2685930 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 132553945 c.1639G>A p.V547I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000395243.3:p.Val547Ile ENST00000454757.6:c.1639G>A 7:g.55165331G>A EGFR ENST00000275493.6 3633 3236 P-0002695-T01-IM3 2718937 2577758 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51788017 COSM6923954 99458218 c.3262C>T p.P1088S Substitution - Missense het 38 7:55202616-55202616 + - PATHOGENIC .96386 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Pro1088Ser ENST00000275493.6:c.3262C>T 7:g.55202616C>T EGFR ENST00000275493.6 3633 3236 A8 2409506 2272386 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25112956 surgery fresh/frozen NS 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MaPT19 2491650 2354291 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007100-T01-IM5 2830046 2685861 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51776957 COSM6955986 132587401 c.2986A>G p.T996A Substitution - Missense 38 7:55201741-55201741 + - PATHOGENIC .92147 Confirmed somatic variant 30205045 surgery-fixed primary 50 ENSP00000395243.3:p.Thr996Ala ENST00000454757.6:c.2986A>G 7:g.55201741A>G EGFR ENST00000275493.6 3633 3236 2876601 2876601 2731116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 99388191 c.2389T>A p.C797S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 surgery fresh/frozen NS 50 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2389T>A 7:g.55181398T>A EGFR ENST00000275493.6 3633 3236 2876601 2876601 2731116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 surgery fresh/frozen NS 50 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876601 2876601 2731116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 surgery fresh/frozen NS 50 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1458681 1458681 1382656 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A102-T-S37 2757415 2616002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458700 1458700 1382675 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876062 2876062 2730577 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 494 898391 816003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-FG-A4MW-01 2194412 2062690 central_nervous_system brain NS NS glioma NS NS NS y COSV51814881 COSM3929116 99399609 c.934G>T p.G312W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 545 NS NS 63 ENSP00000275493.2:p.Gly312Trp ENST00000275493.6:c.934G>T 7:g.55155874G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003752-T03-IM5 2720240 2579061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003752-T03-IM5 2720240 2579061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2152762 2152762 2021772 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 MBC_61 2662766 2522890 breast NS NS NS carcinoma ER-PR-positive_carcinoma NS NS y COSV51771306 COSM1318972 99391332 c.1913C>T p.T638M Substitution - Missense 38 7:55171207-55171207 + - NEUTRAL .03249 Confirmed somatic variant 28027327 fresh/frozen - NOS NS ENSP00000275493.2:p.Thr638Met ENST00000275493.6:c.1913C>T 7:g.55171207C>T EGFR ENST00000275493.6 3633 3236 4769-ca 2823149 2679003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 28818608 surgery-fixed NS 50 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451150 1451150 1375293 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007100-T01-IM5 2830046 2685861 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51776957 COSM6955986 133249041 c.2986A>G p.T996A Substitution - Missense 38 7:55201741-55201741 + - PATHOGENIC .92147 Confirmed somatic variant 30205045 surgery-fixed primary 50 ENSP00000415559.1:p.Thr996Ala ENST00000455089.5:c.2986A>G 7:g.55201741A>G EGFR ENST00000275493.6 3633 3236 2115524 2115524 1989768 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0000630-T01-IM3 2715664 2574485 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-WS012-T2 2869948 2724945 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110279 COSM9809368 133280919 c.299C>T p.P100L Substitution - Missense 38 7:55143363-55143363 + - PATHOGENIC .96024 Confirmed somatic variant 26950094 surgery - NOS NS 82 ENSP00000415559.1:p.Pro100Leu ENST00000455089.5:c.299C>T 7:g.55143363C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD7043a 1504254 1427132 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia NS n COSV51852469 COSM4384119 132553014 c.1282A>G p.N428D Substitution - Missense 38 7:55160257-55160257 + - NEUTRAL .3314 Confirmed somatic variant 24030381 NS NS ENSP00000395243.3:p.Asn428Asp ENST00000454757.6:c.1282A>G 7:g.55160257A>G EGFR ENST00000275493.6 3633 3236 P-0000630-T01-IM3 2715664 2574485 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 TCGA-02-2466-01 2178184 2046482 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 61 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008215-T01-IM5 2830122 2685937 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51834499 COSM6845063 132548992 c.829G>A p.G277S Substitution - Missense 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 30205045 surgery-fixed primary 58 ENSP00000395243.3:p.Gly277Ser ENST00000454757.6:c.829G>A 7:g.55155904G>A OR7C1 ENST00000642030.1 963 8373 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV50183885 COSM1390989 176237087 c.364C>T p.R122C Substitution - Missense 38 19:14799773-14799773 - - .5891 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000493026.1:p.Arg122Cys ENST00000642030.1:c.364C>T 19:g.14799773G>A EGFR ENST00000275493.6 3633 3236 P-0007580-T01-IM5 2723865 2582686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780206 COSM12373 99380273 c.2159C>T p.S720F Substitution - Missense het 38 7:55174018-55174018 + - PATHOGENIC .9768 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ser720Phe ENST00000275493.6:c.2159C>T 7:g.55174018C>T EGFR ENST00000275493.6 3633 3236 P-0007580-T01-IM5 2723865 2582686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1001254 1001254 918477 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 OSCC-GB_00130111 2121052 1995288 upper_aerodigestive_tract mouth NS NS carcinoma NS NS NS y COSV51815394 COSM3715755 133212513 c.603C>A p.S201R Substitution - Missense 38 7:55152655-55152655 + - NEUTRAL .15461 Confirmed somatic variant 539 NS NS ENSP00000415559.1:p.Ser201Arg ENST00000455089.5:c.603C>A 7:g.55152655C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DU-A7TD-01 2339610 2204593 central_nervous_system brain NS NS glioma NS NS NS y COSV99294781 COSM8258176 132594528 c.692A>T p.Q231L Substitution - Missense 38 7:55154090-55154090 + - PATHOGENIC .97144 Confirmed somatic variant 545 NS primary 52 ENSP00000395243.3:p.Gln231Leu ENST00000454757.6:c.692A>T 7:g.55154090A>T EGFR ENST00000275493.6 3633 3236 5 897197 814820 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876046 2876046 2730561 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 52 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LICA-CN-HCC121T 2634168 2494564 liver NS NS NS other neoplasm NS NS y COSV51825459 COSM122789 99385632 c.1423A>G p.I475V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Confirmed somatic variant 660 NS primary 49 ENSP00000275493.2:p.Ile475Val ENST00000275493.6:c.1423A>G 7:g.55160263A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002998-T01-IM3 2719207 2578028 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51805664 COSM6925533 132594986 c.1648T>G p.C550G Substitution - Missense het 38 7:55165340-55165340 + - PATHOGENIC .9957 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Cys550Gly ENST00000454757.6:c.1648T>G 7:g.55165340T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-HT-8107-01 2194409 2062687 central_nervous_system brain NS NS glioma NS NS NS y COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 545 NS NS 62 ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S001076 1027683 944659 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 TCGA-BA-4075-01 2193631 2061909 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99292704 COSM8332917 99404627 c.1637C>A p.P546Q Substitution - Missense 38 7:55163738-55163738 + - PATHOGENIC .97378 Confirmed somatic variant 627 NS NS 49 ENSP00000275493.2:p.Pro546Gln ENST00000275493.6:c.1637C>A 7:g.55163738C>A EGFR ENST00000275493.6 3633 3236 2665864 2665864 2525572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792237 COSM6842523 99385661 c.829_830delinsGA p.M277E Substitution - Missense het 38 7:55154092-55154093 + - Confirmed somatic variant 28979142 surgery - NOS NS 70 ENSP00000275493.2:p.Met277Glu ENST00000275493.6:c.829_830delinsGA 7:g.55154092_55154093delinsGA EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471547 1471547 1395286 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152794 2152794 2021804 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1031893 1031893 948684 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17085664 NS metastasis 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1109725 1109725 1023635 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 53 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206745 1206745 1118623 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008744-T01-IM5 2724793 2583614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1790523 1790523 1693502 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003317-T02-IM5 2719811 2578632 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007319-T01-IM5 2723658 2582479 penis NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51785510 COSM6957413 132547201 c.967G>A p.D323N Substitution - Missense het 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Asp323Asn ENST00000454757.6:c.967G>A 7:g.55156628G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1472954 1472954 1396653 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51816100 COSM13430 133227287 c.2380G>A p.A794T Substitution - Missense 38 7:55191764-55191764 + - PATHOGENIC .98912 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000415559.1:p.Ala794Thr ENST00000455089.5:c.2380G>A 7:g.55191764G>A EGFR ENST00000275493.6 3633 3236 P-0011540-T01-IM5 2727112 2585933 small_intestine ileum NS NS carcinoma adenocarcinoma NS NS n COSV51797215 COSM145360 99385818 c.967G>A p.V323I Substitution - Missense het 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Val323Ile ENST00000275493.6:c.967G>A 7:g.55155907G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-14-1034-02 2120293 1994529 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51775191 COSM1451530 132550172 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 329 NS NS 60 ENSP00000395243.3:p.Gly63Arg ENST00000454757.6:c.187G>A 7:g.55142384G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-EY-A2OM-01 2198301 2066579 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99285698 COSM9064376 133216949 c.698A>G p.D233G Substitution - Missense 38 7:55154096-55154096 + - PATHOGENIC .95224 Confirmed somatic variant 419 NS NS 55 ENSP00000415559.1:p.Asp233Gly ENST00000455089.5:c.698A>G 7:g.55154096A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876616 2876616 2731131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105110312 COSM9869917 132578367 c.2017C>G p.L673V Substitution - Missense 38 7:55174011-55174011 + Yes PATHOGENIC .92276 Confirmed somatic variant 29506987 surgery fresh/frozen NS 76 ENSP00000395243.3:p.Leu673Val ENST00000454757.6:c.2017C>G 7:g.55174011C>G EGFR ENST00000275493.6 3633 3236 P-0003752-T03-IM5 2720240 2579061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0003752-T03-IM5 2720240 2579061 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 618 1630888 1547758 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51797215 COSM145360 133214261 c.832G>A p.V278I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 22158541 blood-bone marrow NS ENSP00000415559.1:p.Val278Ile ENST00000455089.5:c.832G>A 7:g.55155907G>A EGFR ENST00000275493.6 3633 3236 DUMC-05 2748702 2607405 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 29802247 surgery fresh/frozen NS 51 ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152701 2152701 2021711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S0514 897600 815223 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 15118125 surgery - NOS primary ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51860329 COSM13190 133219847 c.2240T>C p.L747P Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .95089 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000415559.1:p.Leu747Pro ENST00000455089.5:c.2240T>C 7:g.55181384T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SA213 1659983 1574311 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS y COSV51858303 COSM214296 133255705 c.1024C>G p.L342V Substitution - Missense 38 7:55156784-55156784 + - PATHOGENIC .93843 Confirmed somatic variant 22495314 fresh/frozen - NOS primary 49 ENSP00000415559.1:p.Leu342Val ENST00000455089.5:c.1024C>G 7:g.55156784C>G EGFR ENST00000275493.6 3633 3236 TCGA-28-1749-01 2178174 2046472 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 99388542 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 NS NS 73 ENSP00000275493.2:p.Thr363Ile ENST00000275493.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876624 2876624 2731139 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 29506987 surgery-fixed NS 48 ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 TCGA-81-5911-01 2120399 1994635 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 33 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007381-T01-IM5 2723717 2582538 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51814979 COSM6957934 133241829 c.1200A>G p.I400M Substitution - Missense het 38 7:55160175-55160175 + - NEUTRAL .42702 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ile400Met ENST00000455089.5:c.1200A>G 7:g.55160175A>G POLR1A_ENST00000409681 ENST00000409681.1 4980 17264 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105848950 COSM10012940 123066963 c.4483A>T p.T1495S Substitution - Missense 38 2:86030309-86030309 - - PATHOGENIC .96985 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000386300.1:p.Thr1495Ser ENST00000409681.1:c.4483A>T 2:g.86030309T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Br02X 1312964 1223873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 xenograft primary 39 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 TCGA-S9-A6WN-01 2263420 2130404 central_nervous_system brain NS NS glioma NS NS NS y COSV99292726 COSM8266258 99404698 c.2672A>G p.Y891C Substitution - Missense 38 7:55192812-55192812 + - PATHOGENIC .89661 Confirmed somatic variant 545 NS primary 38 ENSP00000275493.2:p.Tyr891Cys ENST00000275493.6:c.2672A>G 7:g.55192812A>G MTCL1_ENST00000400050 ENST00000400050.7 4761 29121 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV60406354 COSM5665008 119289320 c.1081G>A p.A361T Substitution - Missense 38 18:8784193-8784193 + - PATHOGENIC .91329 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000382924.4:p.Ala361Thr ENST00000400050.7:c.1081G>A 18:g.8784193G>A EGFR ENST00000275493.6 3633 3236 S001094 1027685 944661 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CRC65 2730847 2589616 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV105863705 COSM10062224 132547330 c.193T>G p.L65V Substitution - Missense 38 7:55142390-55142390 + - PATHOGENIC .83273 Confirmed somatic variant 26416732 xenograft metastasis 45 ENSP00000395243.3:p.Leu65Val ENST00000454757.6:c.193T>G 7:g.55142390T>G EGFR ENST00000275493.6 3633 3236 2115514 2115514 1989758 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008145-T02-IM5 2724310 2583131 breast NS NS NS carcinoma NS NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 1472954 1472954 1396653 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51816100 COSM13430 99401741 c.2515G>A p.A839T Substitution - Missense 38 7:55191764-55191764 + - PATHOGENIC .98912 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000275493.2:p.Ala839Thr ENST00000275493.6:c.2515G>A 7:g.55191764G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801757 COSM3923815 132593035 c.2737C>T p.R913C Substitution - Missense 38 7:55200339-55200339 + - PATHOGENIC .97155 Confirmed somatic variant 540 NS NS 68 ENSP00000395243.3:p.Arg913Cys ENST00000454757.6:c.2737C>T 7:g.55200339C>T EGFR ENST00000275493.6 3633 3236 TCGA-02-2485-01 1337809 1248194 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 99377226 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 NS NS 53 ENSP00000275493.2:p.Ala289Asp ENST00000275493.6:c.866C>A 7:g.55154129C>A EGFR ENST00000275493.6 3633 3236 1468098 1468098 1391944 peritoneum NS NS NS mesothelioma NS NS NS n COSV51801471 COSM53105 99379999 c.2492G>A p.R831H Substitution - Missense het 38 7:55191741-55191741 + - PATHOGENIC .96289 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000275493.2:p.Arg831His ENST00000275493.6:c.2492G>A 7:g.55191741G>A EVA1C_ENST00000401402 ENST00000401402.7 1182 13239 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105891752 COSM10012968 117641491 c.736G>A p.G246R Substitution - Missense 38 21:32503946-32503946 + - NEUTRAL .06179 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000384594.3:p.Gly246Arg ENST00000401402.7:c.736G>A 21:g.32503946G>A BRAF_ENST00000644969 ENST00000644969.1 2424 1097 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV56056643 COSM476 175694191 c.1919T>A p.V640E Substitution - Missense 38 7:140753336-140753336 - - PATHOGENIC .98542 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000496776.1:p.Val640Glu ENST00000644969.1:c.1919T>A 7:g.140753336A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-81-5911-01 2120399 1994635 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 33 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-02-2485-01 1337809 1248194 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 132550339 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 NS NS 53 ENSP00000395243.3:p.Ala244Asp ENST00000454757.6:c.731C>A 7:g.55154129C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0185 2107964 1985825 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774819 COSM35840 133207029 c.1816G>A p.V606M Substitution - Missense 38 7:55173014-55173014 + - PATHOGENIC .99458 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Val606Met ENST00000455089.5:c.1816G>A 7:g.55173014G>A EGFR ENST00000275493.6 3633 3236 SA213 1659983 1574311 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS y COSV51858303 COSM214296 99432122 c.1159C>G p.L387V Substitution - Missense 38 7:55156784-55156784 + - PATHOGENIC .93843 Confirmed somatic variant 22495314 fresh/frozen - NOS primary 49 ENSP00000275493.2:p.Leu387Val ENST00000275493.6:c.1159C>G 7:g.55156784C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GYWU_534 2771325 2629517 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV99291764 COSM7410245 133216258 c.2809C>A p.Q937K Substitution - Missense 38 7:55200411-55200411 + - PATHOGENIC .99148 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000415559.1:p.Gln937Lys ENST00000455089.5:c.2809C>A 7:g.55200411C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004795-T01-IM5 2721198 2580019 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS n COSV51783428 COSM6848064 132562284 c.2795G>A p.R932H Substitution - Missense het 38 7:55200397-55200397 + - PATHOGENIC .99379 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Arg932His ENST00000454757.6:c.2795G>A 7:g.55200397G>A EGFR ENST00000275493.6 3633 3236 1318439 1318439 1229337 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM26132 178386036 c.? p.Y727H Substitution - Missense + - Confirmed somatic variant 19812598 fixed - NOS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1505364 1505364 1428242 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51825402 COSM53201 133242605 c.2411A>G p.Q804R Substitution - Missense 38 7:55191795-55191795 + - PATHOGENIC .9858 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000415559.1:p.Gln804Arg ENST00000455089.5:c.2411A>G 7:g.55191795A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV51778830 COSM1698691 132552104 c.1063G>A p.E355K Substitution - Missense 38 7:55156823-55156823 + - PATHOGENIC .99571 Confirmed somatic variant 540 NS NS 90 ENSP00000395243.3:p.Glu355Lys ENST00000454757.6:c.1063G>A 7:g.55156823G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-28-5207 2108065 1985926 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 94128 2807570 2664271 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51832266 COSM6926001 99399159 c.3409G>A p.E1137K Substitution - Missense 38 7:55205393-55205393 + - PATHOGENIC .98342 Confirmed somatic variant 24807215 surgery fresh/frozen primary 75 ENSP00000275493.2:p.Glu1137Lys ENST00000275493.6:c.3409G>A 7:g.55205393G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T407 2296247 2161850 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51776282 COSM1168015 133202278 c.2123C>T p.P708L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Confirmed somatic variant 25344691 NS NS 69.16 ENSP00000415559.1:p.Pro708Leu ENST00000455089.5:c.2123C>T 7:g.55174795C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-F1-6177-01 2198156 2066434 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51817351 COSM3881830 132566658 c.2957G>A p.R986Q Substitution - Missense 38 7:55201333-55201333 + - PATHOGENIC .98371 Confirmed somatic variant 541 NS NS 90 ENSP00000395243.3:p.Arg986Gln ENST00000454757.6:c.2957G>A 7:g.55201333G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0750 2107989 1985850 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51807036 COSM2151966 132561349 c.1652C>G p.P551R Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99615 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Pro551Arg ENST00000454757.6:c.1652C>G 7:g.55165344C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-76-6656-01 2120392 1994628 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51857475 COSM3412176 132586738 c.584G>A p.C195Y Substitution - Missense 38 7:55152636-55152636 + - PATHOGENIC .99504 Confirmed somatic variant 329 NS NS 66 ENSP00000395243.3:p.Cys195Tyr ENST00000454757.6:c.584G>A 7:g.55152636G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007381-T01-IM5 2723717 2582538 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51814979 COSM6957934 132580725 c.1200A>G p.I400M Substitution - Missense het 38 7:55160175-55160175 + - NEUTRAL .42702 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ile400Met ENST00000454757.6:c.1200A>G 7:g.55160175A>G EGFR ENST00000275493.6 3633 3236 P-0008215-T01-IM5 2830122 2685937 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51834499 COSM6845063 99375657 c.964G>A p.G322S Substitution - Missense 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 30205045 surgery-fixed primary 58 ENSP00000275493.2:p.Gly322Ser ENST00000275493.6:c.964G>A 7:g.55155904G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-0185 2107964 1985825 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774819 COSM35840 99378923 c.1951G>A p.V651M Substitution - Missense 38 7:55173014-55173014 + - PATHOGENIC .99458 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Val651Met ENST00000275493.6:c.1951G>A 7:g.55173014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Br02X 1312964 1223873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 xenograft primary 39 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 133206822 c.652A>C p.T218P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr218Pro ENST00000455089.5:c.652A>C 7:g.55154050A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 132551880 c.652A>C p.T218P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr218Pro ENST00000454757.6:c.652A>C 7:g.55154050A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DU-A7TD-01 2339610 2204593 central_nervous_system brain NS NS glioma NS NS NS y COSV99294781 COSM8258176 133257580 c.692A>T p.Q231L Substitution - Missense 38 7:55154090-55154090 + - PATHOGENIC .97144 Confirmed somatic variant 545 NS primary 52 ENSP00000415559.1:p.Gln231Leu ENST00000455089.5:c.692A>T 7:g.55154090A>T EGFR ENST00000275493.6 3633 3236 2876034 2876034 2730549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832145 COSM6493936 99406880 c.2389T>G p.C797G Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95801 Confirmed somatic variant 29506987 circulating tumour recurrent 44 ENSP00000275493.2:p.Cys797Gly ENST00000275493.6:c.2389T>G 7:g.55181398T>G NBPF3_ENST00000619554 ENST00000619554.1 1734 25076 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV59056369 COSM4166741 167698054 c.1103T>G p.F368C Substitution - Missense 38 1:21480113-21480113 + - NEUTRAL .00026 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000484028.1:p.Phe368Cys ENST00000619554.1:c.1103T>G 1:g.21480113T>G EGFR ENST00000275493.6 3633 3236 1505364 1505364 1428242 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51825402 COSM53201 99417170 c.2546A>G p.Q849R Substitution - Missense 38 7:55191795-55191795 + - PATHOGENIC .9858 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000275493.2:p.Gln849Arg ENST00000275493.6:c.2546A>G 7:g.55191795A>G EGFR ENST00000275493.6 3633 3236 1468642 1468642 1392393 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S001094 1027685 944661 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 TCGA-28-5207 2108065 1985926 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 T407 2296247 2161850 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51776282 COSM1168015 99373518 c.2258C>T p.P753L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Confirmed somatic variant 25344691 NS NS 69.16 ENSP00000275493.2:p.Pro753Leu ENST00000275493.6:c.2258C>T 7:g.55174795C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EXTERN_MELA_20140505_038 2839416 2695182 skin ear NS NS malignant_melanoma NS NS NS y COSV104577055 COSM9446911 133228126 c.752C>T p.P251L Substitution - Missense 38 7:55154150-55154150 + - PATHOGENIC .98876 Confirmed somatic variant 28467829 surgery fresh/frozen recurrent ENSP00000415559.1:p.Pro251Leu ENST00000455089.5:c.752C>T 7:g.55154150C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-WE-AAA4-06 2339475 2204458 skin NS NS NS malignant_melanoma NS NS NS y COSV99286479 COSM8046349 133221007 c.1255T>C p.S419P Substitution - Missense 38 7:55160230-55160230 + - PATHOGENIC .73545 Confirmed somatic variant 540 NS NS 56 ENSP00000415559.1:p.Ser419Pro ENST00000455089.5:c.1255T>C 7:g.55160230T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876034 2876034 2730549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 132560202 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour recurrent 44 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2254T>A 7:g.55181398T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T2457 2658705 2518864 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51789934 COSM6652266 133219593 c.3041C>T p.P1014L Substitution - Missense 38 7:55202530-55202530 + - PATHOGENIC .92486 Confirmed somatic variant 27149842 NS NS 75.08 ENSP00000415559.1:p.Pro1014Leu ENST00000455089.5:c.3041C>T 7:g.55202530C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152699 2152699 2021709 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 EXTERN_MELA_20140505_038 2839416 2695182 skin ear NS NS malignant_melanoma NS NS NS y COSV104577055 COSM9446911 99402479 c.887C>T p.P296L Substitution - Missense 38 7:55154150-55154150 + - PATHOGENIC .98876 Confirmed somatic variant 28467829 surgery fresh/frozen recurrent ENSP00000275493.2:p.Pro296Leu ENST00000275493.6:c.887C>T 7:g.55154150C>T EGFR ENST00000275493.6 3633 3236 2766019 2766019 2624253 breast NS NS NS carcinoma HER-positive_carcinoma NS NS n COSM1166943 178385114 c.? p.V769L Substitution - Missense + - Confirmed somatic variant 30023006 surgery-fixed NS ENSP00000275493.2:p.Val769Leu EGFR_ENST00000455089 ENST00000455089.5 3276 3236 7T 2473854 2336624 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51797600 COSM5575629 133226884 c.391G>A p.G131R Substitution - Missense 38 7:55143455-55143455 + - PATHOGENIC .99768 Confirmed somatic variant 26489445 fixed - NOS NS ENSP00000415559.1:p.Gly131Arg ENST00000455089.5:c.391G>A 7:g.55143455G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004328-T02-IM5 2720735 2579556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 982790 982790 898509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 TCGA-WE-AAA4-06 2339475 2204458 skin NS NS NS malignant_melanoma NS NS NS y COSV99286479 COSM8046349 99394038 c.1390T>C p.S464P Substitution - Missense 38 7:55160230-55160230 + - PATHOGENIC .73545 Confirmed somatic variant 540 NS NS 56 ENSP00000275493.2:p.Ser464Pro ENST00000275493.6:c.1390T>C 7:g.55160230T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 128 2748100 2606803 stomach NS NS NS carcinoma NS NS NS y COSV99288147 COSM8566415 132605141 c.2696A>G p.Y899C Substitution - Missense 38 7:55198846-55198846 + - PATHOGENIC .98856 Confirmed somatic variant 683 NS primary ENSP00000395243.3:p.Tyr899Cys ENST00000454757.6:c.2696A>G 7:g.55198846A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007663-T01-IM5 2723937 2582758 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914584 914584 832033 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 80 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211135 1211135 1123003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 53 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008705-T01-IM5 2724760 2583581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003213-T01-IM5 2719708 2578529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982856 982856 898575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920021 920021 837100 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004994 1004994 922206 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009260-T01-IM5 2725217 2584038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811961 2811961 2668496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 78 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471567 1471567 1395306 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458695 1458695 1382670 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812090 2812090 2668555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 79 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004328-T01-IM5 2720736 2579557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458686 1458686 1382661 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_S24 1863735 1754626 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2591415 2591415 2452375 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591415 2591415 2452375 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982776 982776 898495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982776 982776 898495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001215-T01-IM3 2716848 2575669 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51857792 COSM6915600 132552843 c.3485T>G p.F1162C Substitution - Missense het 38 7:55205604-55205604 + - PATHOGENIC .74607 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Phe1162Cys ENST00000454757.6:c.3485T>G 7:g.55205604T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010340-T01-IM5 2726107 2584928 NS NS NS NS malignant_melanoma NS NS NS n COSV51799199 COSM1251020 133209185 c.1639G>A p.V547I Substitution - Missense het 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Val547Ile ENST00000455089.5:c.1639G>A 7:g.55165331G>A EGFR ENST00000275493.6 3633 3236 618 1630888 1547758 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51797215 COSM145360 99385818 c.967G>A p.V323I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 22158541 blood-bone marrow NS ENSP00000275493.2:p.Val323Ile ENST00000275493.6:c.967G>A 7:g.55155907G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD4604a 1356528 1266569 breast NS NS NS carcinoma lobular_carcinoma NS NS y COSV51822879 COSM4680399 132555327 c.1904G>A p.R635Q Substitution - Missense 38 7:55173102-55173102 + - PATHOGENIC .99814 Confirmed somatic variant 652 NS primary ENSP00000395243.3:p.Arg635Gln ENST00000454757.6:c.1904G>A 7:g.55173102G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV99296117 COSM7998157 133229596 c.1815G>A p.M605I Substitution - Missense 38 7:55173013-55173013 + - NEUTRAL .06549 Confirmed somatic variant 540 NS NS 90 ENSP00000415559.1:p.Met605Ile ENST00000455089.5:c.1815G>A 7:g.55173013G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812096 2812096 2668558 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 pleural effusion NS 78 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1179730 1179730 1091692 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 19096324 NS primary 62 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002091-T02-IM5 2719479 2578300 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211138 1211138 1123006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 85 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006105-T01-IM5 2722481 2581302 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T_CCA_SG_13 2688086 2547068 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV51803429 COSM7002279 132557298 c.1145G>A p.R382H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Confirmed somatic variant 653 NS primary 60 ENSP00000395243.3:p.Arg382His ENST00000454757.6:c.1145G>A 7:g.55157735G>A EGFR ENST00000275493.6 3633 3236 1091706 1091706 1006528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26137 178380447 c.? p.T847A Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 MaPT10 2491641 2354282 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 2812078 2812078 2668549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51776947 COSM6910370 99393548 c.2497T>A p.L833M Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .36784 Confirmed somatic variant 31534501 pleural effusion NS 72 ENSP00000275493.2:p.Leu833Met ENST00000275493.6:c.2497T>A 7:g.55191746T>A EGFR ENST00000275493.6 3633 3236 1458686 1458686 1382661 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LC_S24 1863735 1754626 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982776 982776 898495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 982776 982776 898495 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 TCGA-DU-A7TD-01 2339610 2204593 central_nervous_system brain NS NS glioma NS NS NS y COSV99294781 COSM8258176 99434350 c.827A>T p.Q276L Substitution - Missense 38 7:55154090-55154090 + - PATHOGENIC .97144 Confirmed somatic variant 545 NS primary 52 ENSP00000275493.2:p.Gln276Leu ENST00000275493.6:c.827A>T 7:g.55154090A>T EGFR ENST00000275493.6 3633 3236 1091716 1091716 1006538 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM26143 178383091 c.? p.E711K Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS ENSP00000275493.2:p.Glu711Lys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 10677523 2751151 2609847 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV105822269 COSM9522392 133224412 c.871G>C p.V291L Substitution - Missense 38 7:55155946-55155946 + - Confirmed somatic variant 29748005 circulating tumour NS ENSP00000415559.1:p.Val291Leu ENST00000455089.5:c.871G>C 7:g.55155946G>C EGFR ENST00000275493.6 3633 3236 P-0010340-T01-IM5 2726107 2584928 NS NS NS NS malignant_melanoma NS NS NS n COSV51799199 COSM1251020 99380942 c.1774G>A p.V592I Substitution - Missense het 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Val592Ile ENST00000275493.6:c.1774G>A 7:g.55165331G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471534 1471534 1395273 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876616 2876616 2731131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 surgery fresh/frozen NS 76 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206718 1206718 1118596 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1179551 1179551 1091513 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 55 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009873-T01-IM5 2725712 2584533 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 10677523 2751151 2609847 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV105822270 COSM9522396 132567692 c.1649G>C p.C550S Substitution - Missense 38 7:55165341-55165341 + - Confirmed somatic variant 29748005 circulating tumour NS ENSP00000395243.3:p.Cys550Ser ENST00000454757.6:c.1649G>C 7:g.55165341G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982850 982850 898569 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489255 1489255 1412413 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008744-T02-IM5 2724794 2583615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-24-2289-01 1475125 1398824 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51801941 COSM116797 132570131 c.2012A>G p.K671R Substitution - Missense het 38 7:55174006-55174006 + - PATHOGENIC .96091 Confirmed somatic variant 21720365 331 NS primary 68 ENSP00000395243.3:p.Lys671Arg ENST00000454757.6:c.2012A>G 7:g.55174006A>G EGFR ENST00000275493.6 3633 3236 TCGA-14-0789-01 1337988 1248373 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51851464 COSM3412200 99423776 c.1883G>A p.C628Y Substitution - Missense 38 7:55171177-55171177 + - PATHOGENIC .98191 Confirmed somatic variant 329 surgery fresh/frozen NS 54 ENSP00000275493.2:p.Cys628Tyr ENST00000275493.6:c.1883G>A 7:g.55171177G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000348-T01-IM3 2715088 2573909 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 132550443 c.2104_2105delinsCC p.L702P Substitution - Missense het 38 7:55174776-55174777 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu702Pro ENST00000454757.6:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD42114a 2894823 2749311 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV105111067 COSM9915039 133284424 c.2963C>T p.P988L Substitution - Missense 38 7:55201339-55201339 + - PATHOGENIC .98608 Confirmed somatic variant 33024263 surgery-fixed metastasis 54 ENSP00000415559.1:p.Pro988Leu ENST00000455089.5:c.2963C>T 7:g.55201339C>T EGFR ENST00000275493.6 3633 3236 1054310 1054310 970381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 17409862 surgery - NOS primary 49 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 CCRF-CEM 1998437 1883509 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51787208 COSM327142 99376659 c.3352G>A p.A1118T Substitution - Missense het 38 7:55205336-55205336 + - NEUTRAL .10522 Confirmed somatic variant 23856246 cell-line primary ENSP00000275493.2:p.Ala1118Thr ENST00000275493.6:c.3352G>A 7:g.55205336G>A EGFR ENST00000275493.6 3633 3236 B105-1 2097255 1975319 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV51787208 COSM327142 99376659 c.3352G>A p.A1118T Substitution - Missense 38 7:55205336-55205336 + - NEUTRAL .10522 Confirmed somatic variant 24121792 fresh/frozen - NOS NS ENSP00000275493.2:p.Ala1118Thr ENST00000275493.6:c.3352G>A 7:g.55205336G>A EGFR ENST00000275493.6 3633 3236 SJALL040461-D 2824035 2679863 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV104576718 COSM9280424 99388710 c.1592G>A p.R531Q Substitution - Missense 38 7:55161592-55161592 + - PATHOGENIC .99386 Confirmed somatic variant 31697823 blood-bone marrow NS 11.64 ENSP00000275493.2:p.Arg531Gln ENST00000275493.6:c.1592G>A 7:g.55161592G>A CHD9_ENST00000564845 ENST00000564845.5 8646 25701 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105871502 COSM10012854 160518219 c.7071A>C p.E2357D Substitution - Missense 38 16:53308751-53308751 + - PATHOGENIC .86656 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000455307.1:p.Glu2357Asp ENST00000564845.5:c.7071A>C 16:g.53308751A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 7T 2473854 2336624 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51794834 COSM5575633 132558496 c.2738G>A p.R913H Substitution - Missense 38 7:55200340-55200340 + - PATHOGENIC .99504 Confirmed somatic variant 26489445 fixed - NOS NS ENSP00000395243.3:p.Arg913His ENST00000454757.6:c.2738G>A 7:g.55200340G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-CV-6961-01 2193755 2062033 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51839851 COSM7340115 132572537 c.983C>A p.P328Q Substitution - Missense 38 7:55156644-55156644 + - PATHOGENIC .76649 Confirmed somatic variant 627 NS NS 61 ENSP00000395243.3:p.Pro328Gln ENST00000454757.6:c.983C>A 7:g.55156644C>A EGFR ENST00000275493.6 3633 3236 P-0009873-T01-IM5 2725712 2584533 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AC-A23H-01 2187848 2056126 breast NS NS NS carcinoma NS NS NS y COSV51765875 COSM3833029 133233703 c.3016G>A p.D1006N Substitution - Missense 38 7:55201771-55201771 + - NEUTRAL .4855 Confirmed somatic variant 414 NS NS 90 ENSP00000415559.1:p.Asp1006Asn ENST00000455089.5:c.3016G>A 7:g.55201771G>A EGFR ENST00000275493.6 3633 3236 2901983 2901983 2756227 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 2760844 2760844 2619353 central_nervous_system temporal_lobe NS NS glioma gliosarcoma NS NS n COSM23613 178378830 c.? p.G719D Substitution - Missense + - Confirmed somatic variant 29416795 surgery - NOS recurrent 57 ENSP00000275493.2:p.Gly719Asp EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SJALL040461-D 2824035 2679863 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV104576718 COSM9280424 133216650 c.1457G>A p.R486Q Substitution - Missense 38 7:55161592-55161592 + - PATHOGENIC .99386 Confirmed somatic variant 31697823 blood-bone marrow NS 11.64 ENSP00000415559.1:p.Arg486Gln ENST00000455089.5:c.1457G>A 7:g.55161592G>A EGFR ENST00000275493.6 3633 3236 5-VS083-T1 2869916 2724913 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51776967 COSM6963220 99390712 c.1930C>T p.P644S Substitution - Missense 38 7:55172993-55172993 + - PATHOGENIC .96242 Confirmed somatic variant 26950094 surgery - NOS NS 72 ENSP00000275493.2:p.Pro644Ser ENST00000275493.6:c.1930C>T 7:g.55172993C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51865283 COSM6970485 132611759 c.188G>A p.G63E Substitution - Missense het 38 7:55142385-55142385 + - PATHOGENIC .95671 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Gly63Glu ENST00000454757.6:c.188G>A 7:g.55142385G>A EGFR ENST00000275493.6 3633 3236 T578 2658233 2518392 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51788796 COSM4680390 99401501 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 27149842 NS NS 61.08 ENSP00000275493.2:p.Arg98Gln ENST00000275493.6:c.293G>A 7:g.55143357G>A EGFR ENST00000275493.6 3633 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51770694 COSM20891 99391373 c.2386G>A p.G796S Substitution - Missense 38 7:55181395-55181395 + Yes PATHOGENIC .98244 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000275493.2:p.Gly796Ser ENST00000275493.6:c.2386G>A 7:g.55181395G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BP-4341-01 2120462 1994698 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51785438 COSM3366978 133244411 c.2360G>A p.R787H Substitution - Missense 38 7:55191744-55191744 + - PATHOGENIC .9403 Confirmed somatic variant 416 NS NS 67 ENSP00000415559.1:p.Arg787His ENST00000455089.5:c.2360G>A 7:g.55191744G>A EGFR ENST00000275493.6 3633 3236 7T 2473854 2336624 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51797642 COSM5575634 99401496 c.3419A>G p.N1140S Substitution - Missense 38 7:55205403-55205403 + - PATHOGENIC .97276 Confirmed somatic variant 26489445 fixed - NOS NS ENSP00000275493.2:p.Asn1140Ser ENST00000275493.6:c.3419A>G 7:g.55205403A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471567 1471567 1395306 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 2690101 2690101 2549076 upper_aerodigestive_tract sinonasal_and_nasal_cavity NS NS carcinoma undifferentiated_carcinoma NS NS n COSM6904471 178378653 c.? p.E319K Substitution - Missense + - Confirmed somatic variant 28493366 surgery-fixed primary 48 ENSP00000275493.2:p.Glu319Lys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-81-5911-01 2120399 1994635 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 33 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801748 COSM3923814 132593030 c.2665C>T p.P889S Substitution - Missense 38 7:55198815-55198815 + - PATHOGENIC .94851 Confirmed somatic variant 540 NS NS 68 ENSP00000395243.3:p.Pro889Ser ENST00000454757.6:c.2665C>T 7:g.55198815C>T EGFR ENST00000275493.6 3633 3236 S0514 897600 815223 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 15118125 surgery - NOS primary ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2152701 2152701 2021711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD42114a 2894823 2749311 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV105111067 COSM9915039 132621249 c.2963C>T p.P988L Substitution - Missense 38 7:55201339-55201339 + - PATHOGENIC .98608 Confirmed somatic variant 33024263 surgery-fixed metastasis 54 ENSP00000395243.3:p.Pro988Leu ENST00000454757.6:c.2963C>T 7:g.55201339C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 132563564 c.2240T>A p.L747H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000395243.3:p.Leu747His ENST00000454757.6:c.2240T>A 7:g.55181384T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001649-T01-IM3 2717717 2576538 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS n COSV51792269 COSM6918047 132578911 c.2308C>T p.L770F Substitution - Missense het 38 7:55181452-55181452 + - PATHOGENIC .96277 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu770Phe ENST00000454757.6:c.2308C>T 7:g.55181452C>T EGFR ENST00000275493.6 3633 3236 1595808 1595808 1516605 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51793896 COSM22954 99389719 c.2324G>A p.C775Y Substitution - Missense hom 38 7:55181333-55181333 + - PATHOGENIC .97278 Confirmed somatic variant 16551849 surgery-fixed NS 70 ENSP00000275493.2:p.Cys775Tyr ENST00000275493.6:c.2324G>A 7:g.55181333G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MELA_34952 2760718 2619251 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV51785510 COSM6957413 132547201 c.967G>A p.D323N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 30178487 surgery fresh/frozen metastasis 25 ENSP00000395243.3:p.Asp323Asn ENST00000454757.6:c.967G>A 7:g.55156628G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 R056-I1 2813481 2669873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289246 COSM8268187 132551517 c.653C>T p.T218I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 28263318 surgery fresh/frozen NS 42 ENSP00000395243.3:p.Thr218Ile ENST00000454757.6:c.653C>T 7:g.55154051C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982787 982787 898506 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914587 914587 832036 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 49 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471561 1471561 1395300 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 OSCC-GB_00550111 2340760 2205743 upper_aerodigestive_tract mouth NS NS carcinoma NS NS NS y COSV51836185 COSM4884832 133234939 c.604G>T p.D202Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 539 NS primary 58 ENSP00000415559.1:p.Asp202Tyr ENST00000455089.5:c.604G>T 7:g.55152656G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812078 2812078 2668549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 31534501 pleural effusion NS 72 ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007842-T01-IM5 2724054 2582875 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1468098 1468098 1391944 peritoneum NS NS NS mesothelioma NS NS NS n COSV51801471 COSM53105 132553118 c.2357G>A p.R786H Substitution - Missense het 38 7:55191741-55191741 + - PATHOGENIC .96289 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000395243.3:p.Arg786His ENST00000454757.6:c.2357G>A 7:g.55191741G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-GM-A2DD-01 2187736 2056014 breast NS NS NS carcinoma NS NS NS y COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 414 NS NS 53 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Br112X 1313001 1223910 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 18772396 xenograft primary 48 ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A114-T-S23 2757426 2616005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 61 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152773 2152773 2021783 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A021-T-S02 2757379 2615995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 57 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010337-T01-IM5 2726104 2584925 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982877 982877 898596 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004066-T01-IM5 2720468 2579289 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1044280 1044280 960621 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 41 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DUMC-05 2748702 2607405 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 29802247 surgery fresh/frozen NS 51 ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876056 2876056 2730571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 56 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_S25 1863736 1754627 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 78 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_C3 1863684 1754575 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 65 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-14-0789-01 1337988 1248373 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51851464 COSM3412200 132586535 c.1748G>A p.C583Y Substitution - Missense 38 7:55171177-55171177 + - PATHOGENIC .98191 Confirmed somatic variant 329 surgery fresh/frozen NS 54 ENSP00000395243.3:p.Cys583Tyr ENST00000454757.6:c.1748G>A 7:g.55171177G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005000 1005000 922212 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 IGC-11-1112 2662356 2522480 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812093 2812093 2668556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 59 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008285-T01-IM5 2724413 2583234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007084-T02-IM5 2723457 2582278 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51797839 COSM6958991 132579756 c.37G>A p.A13T Substitution - Missense het 38 7:55019314-55019314 + - NEUTRAL .01885 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ala13Thr ENST00000454757.6:c.37G>A 7:g.55019314G>A EGFR ENST00000275493.6 3633 3236 2115517 2115517 1989761 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1317164 1317164 1228065 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20126411 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 914587 914587 832036 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 49 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51781835 COSM174732 132552286 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Glu114Lys ENST00000454757.6:c.340G>A 7:g.55143404G>A EGFR ENST00000275493.6 3633 3236 1471561 1471561 1395300 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1468644 1468644 1392395 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468650 1468650 1392401 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 OSCC-GB_00550111 2340760 2205743 upper_aerodigestive_tract mouth NS NS carcinoma NS NS NS y COSV51836185 COSM4884832 99407985 c.739G>T p.D247Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 539 NS primary 58 ENSP00000275493.2:p.Asp247Tyr ENST00000275493.6:c.739G>T 7:g.55152656G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-HT-8107-01 2194409 2062687 central_nervous_system brain NS NS glioma NS NS NS y COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 545 NS NS 62 ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S001076 1027683 944659 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 WD_09 2688643 2547625 skin hand NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51780206 COSM12373 132553376 c.2024C>T p.S675F Substitution - Missense het 38 7:55174018-55174018 + - PATHOGENIC .9768 Confirmed somatic variant 24662767 surgery fresh/frozen NS 58 ENSP00000395243.3:p.Ser675Phe ENST00000454757.6:c.2024C>T 7:g.55174018C>T EGFR ENST00000275493.6 3633 3236 7T 2473854 2336624 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51797600 COSM5575629 99401472 c.391G>A p.G131R Substitution - Missense 38 7:55143455-55143455 + - PATHOGENIC .99768 Confirmed somatic variant 26489445 fixed - NOS NS ENSP00000275493.2:p.Gly131Arg ENST00000275493.6:c.391G>A 7:g.55143455G>A EGFR ENST00000275493.6 3633 3236 TCGA-28-5213-01 2120336 1994572 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 72 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-A6-3809-01 1901050 1789730 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51814970 COSM6942061 132584222 c.3319G>A p.D1107N Substitution - Missense 38 7:55205438-55205438 + - .52145 Confirmed somatic variant 376 fresh/frozen - NOS primary 71 ENSP00000395243.3:p.Asp1107Asn ENST00000454757.6:c.3319G>A 7:g.55205438G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-14-0789-01 1337988 1248373 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51851464 COSM3412200 133248140 c.1748G>A p.C583Y Substitution - Missense 38 7:55171177-55171177 + - PATHOGENIC .98191 Confirmed somatic variant 329 surgery fresh/frozen NS 54 ENSP00000415559.1:p.Cys583Tyr ENST00000455089.5:c.1748G>A 7:g.55171177G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CTS175 2393056 2255887 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 56 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982853 982853 898572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876661 2876661 2731176 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007846-T01-IM5 2724058 2582879 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206715 1206715 1118593 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458690 1458690 1382665 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 134 897200 814823 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152790 2152790 2021800 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A062-T-S11 2757397 2615999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811978 2811978 2668502 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed NS 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A021-T-S20 2757382 2615995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 57 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811999 2811999 2668509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed NS 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005011 1005011 922223 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004992 1004992 922204 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-55-8096-01 2194781 2063059 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SK-MEL-28 1998476 1883548 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm hairy_cell_leukaemia NS NS y COSV51778029 COSM6268 133209348 c.2122C>T p.P708S Substitution - Missense hom 38 7:55174794-55174794 + - PATHOGENIC .98527 Confirmed somatic variant 23856246 cell-line primary ENSP00000415559.1:p.Pro708Ser ENST00000455089.5:c.2122C>T 7:g.55174794C>T EGFR ENST00000275493.6 3633 3236 10677523 2751151 2609847 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV105822270 COSM9522396 99399324 c.1784G>C p.C595S Substitution - Missense 38 7:55165341-55165341 + - Confirmed somatic variant 29748005 circulating tumour NS ENSP00000275493.2:p.Cys595Ser ENST00000275493.6:c.1784G>C 7:g.55165341G>C EGFR ENST00000275493.6 3633 3236 1451160 1451160 1375303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-13-0912-01 1474988 1398687 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51781835 COSM174732 99379122 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 331 NS primary 58 ENSP00000275493.2:p.Glu114Lys ENST00000275493.6:c.340G>A 7:g.55143404G>A EGFR ENST00000275493.6 3633 3236 TCGA-13-0912-01 1474988 1398687 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51781835 COSM174732 99379122 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 21720365 331 NS primary 58 ENSP00000275493.2:p.Glu114Lys ENST00000275493.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011029-T02-IM5 2726667 2585488 skin mucosal vagina NS malignant_melanoma NS NS NS n COSV51814016 COSM6978576 133211427 c.3113A>G p.D1038G Substitution - Missense het 38 7:55202602-55202602 + - PATHOGENIC .96122 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Asp1038Gly ENST00000455089.5:c.3113A>G 7:g.55202602A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0013082-T01-IM5 2803825 2660575 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51769863 COSM1090888 132554400 c.2089G>A p.V697I Substitution - Missense het 38 7:55174761-55174761 + - PATHOGENIC .99624 Confirmed somatic variant 29316426 surgery-fixed primary 41 ENSP00000395243.3:p.Val697Ile ENST00000454757.6:c.2089G>A 7:g.55174761G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DI-A1BU-01 2198300 2066578 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99287849 COSM8863291 132571200 c.1531A>G p.I511V Substitution - Missense 38 7:55163767-55163767 + - NEUTRAL .09266 Confirmed somatic variant 419 NS NS 55 ENSP00000395243.3:p.Ile511Val ENST00000454757.6:c.1531A>G 7:g.55163767A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003108-T01-IM5 2719604 2578425 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51866279 COSM6926300 132551487 c.530G>A p.R177H Substitution - Missense het 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000395243.3:p.Arg177His ENST00000454757.6:c.530G>A 7:g.55152582G>A EGFR ENST00000275493.6 3633 3236 108 2605254 2466145 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Confirmed somatic variant 25376516 surgery - NOS NS 78 ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 STC291 2404163 2267015 stomach NS NS NS carcinoma intestinal_adenocarcinoma NS NS y COSV51772123 COSM3266626 132551356 c.1894C>T p.R632C Substitution - Missense 38 7:55173092-55173092 + - PATHOGENIC .98355 Confirmed somatic variant 25042771 surgery fresh/frozen primary 75 ENSP00000395243.3:p.Arg632Cys ENST00000454757.6:c.1894C>T 7:g.55173092C>T SCN3A_ENST00000409101 ENST00000409101.7 5856 10590 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105872781 COSM10012800 123665425 c.5378T>A p.V1793D Substitution - Missense 38 2:165090628-165090628 - - PATHOGENIC .99267 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000386726.3:p.Val1793Asp ENST00000409101.7:c.5378T>A 2:g.165090628A>T SCN2A ENST00000636071.2 6018 10588 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105873046 COSM10012780 171065465 c.5288C>A p.S1763Y Substitution - Missense 38 2:165389094-165389094 + - PATHOGENIC .98186 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000490107.1:p.Ser1763Tyr ENST00000636071.2:c.5288C>A 2:g.165389094C>A EGFR ENST00000275493.6 3633 3236 2665868 2665868 2525576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM6842527 178378402 c.? p.A508V Substitution - Missense + - Confirmed somatic variant 28979142 surgery - NOS NS ENSP00000275493.2:p.Ala508Val EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51860329 COSM13190 132563568 c.2240T>C p.L747P Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .95089 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000395243.3:p.Leu747Pro ENST00000454757.6:c.2240T>C 7:g.55181384T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV99296117 COSM7998157 132571772 c.1815G>A p.M605I Substitution - Missense 38 7:55173013-55173013 + - NEUTRAL .06549 Confirmed somatic variant 540 NS NS 90 ENSP00000395243.3:p.Met605Ile ENST00000454757.6:c.1815G>A 7:g.55173013G>A EGFR ENST00000275493.6 3633 3236 B72-S1 2732506 2591266 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 99388542 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 29244145 surgery fresh/frozen primary 76.6 ENSP00000275493.2:p.Thr363Ile ENST00000275493.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCG-Testes_DFCI_3-Tumor-SM-4PDD6 2806592 2663310 testis NS NS NS germ_cell_tumour mixed NS NS y COSV99289610 COSM9116988 132560577 c.2944C>T p.P982S Substitution - Missense het 38 7:55201320-55201320 + - PATHOGENIC .99685 Confirmed somatic variant 27905446 fixed - NOS metastasis ENSP00000395243.3:p.Pro982Ser ENST00000454757.6:c.2944C>T 7:g.55201320C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 YUROG 2439363 2302204 skin NS NS NS malignant_melanoma NS NS NS y COSV51803218 COSM5407729 132612994 c.2272C>T p.R758W Substitution - Missense het 38 7:55181416-55181416 + - PATHOGENIC .85795 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 58 ENSP00000395243.3:p.Arg758Trp ENST00000454757.6:c.2272C>T 7:g.55181416C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787557 COSM6191456 132549765 c.1202C>T p.T401I Substitution - Missense 38 7:55160177-55160177 + - NEUTRAL .13103 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000395243.3:p.Thr401Ile ENST00000454757.6:c.1202C>T 7:g.55160177C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EXTERN_MELA_20140924_067 2839387 2695153 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV104577161 COSM9392986 132591482 c.1309G>A p.G437R Substitution - Missense 38 7:55160284-55160284 + - PATHOGENIC .93959 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000395243.3:p.Gly437Arg ENST00000454757.6:c.1309G>A 7:g.55160284G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008346-T01-IM5 2724474 2583295 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51838649 COSM6962468 133243598 c.412A>G p.R138G Substitution - Missense het 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg138Gly ENST00000455089.5:c.412A>G 7:g.55143476A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T578 2658233 2518392 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51788796 COSM4680390 133226922 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 27149842 NS NS 61.08 ENSP00000415559.1:p.Arg98Gln ENST00000455089.5:c.293G>A 7:g.55143357G>A EGFR ENST00000275493.6 3633 3236 TG81531 2823155 2679008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM9274128 178383270 c.? p.L11F Substitution - Missense + - Confirmed somatic variant 28818608 surgery-fixed NS 56 EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-43-A56U-01 2195058 2063336 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99290842 COSM8713904 133268385 c.440C>G p.P147R Substitution - Missense 38 7:55151309-55151309 + - PATHOGENIC .9684 Confirmed somatic variant 418 NS NS 76 ENSP00000415559.1:p.Pro147Arg ENST00000455089.5:c.440C>G 7:g.55151309C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EXTERN_MELA_20140524_020 2839454 2695220 skin trunk NS NS malignant_melanoma NS NS NS y COSV104577006 COSM9447599 133232338 c.2996A>G p.N999S Substitution - Missense 38 7:55201751-55201751 + - NEUTRAL .35447 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000415559.1:p.Asn999Ser ENST00000455089.5:c.2996A>G 7:g.55201751A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 7T 2473854 2336624 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51797600 COSM5575629 132569532 c.391G>A p.G131R Substitution - Missense 38 7:55143455-55143455 + - PATHOGENIC .99768 Confirmed somatic variant 26489445 fixed - NOS NS ENSP00000395243.3:p.Gly131Arg ENST00000454757.6:c.391G>A 7:g.55143455G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-76-6656-01 2120392 1994628 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51857475 COSM3412176 133248369 c.584G>A p.C195Y Substitution - Missense 38 7:55152636-55152636 + - PATHOGENIC .99504 Confirmed somatic variant 329 NS NS 66 ENSP00000415559.1:p.Cys195Tyr ENST00000455089.5:c.584G>A 7:g.55152636G>A EGFR ENST00000275493.6 3633 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV51778830 COSM1698691 99378942 c.1198G>A p.E400K Substitution - Missense 38 7:55156823-55156823 + - PATHOGENIC .99571 Confirmed somatic variant 540 NS NS 90 ENSP00000275493.2:p.Glu400Lys ENST00000275493.6:c.1198G>A 7:g.55156823G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-S9-A6WN-01 2263420 2130404 central_nervous_system brain NS NS glioma NS NS NS y COSV99292726 COSM8266258 132572570 c.2537A>G p.Y846C Substitution - Missense 38 7:55192812-55192812 + - PATHOGENIC .89661 Confirmed somatic variant 545 NS primary 38 ENSP00000395243.3:p.Tyr846Cys ENST00000454757.6:c.2537A>G 7:g.55192812A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 94128 2807570 2664271 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51832266 COSM6926001 132567566 c.3274G>A p.E1092K Substitution - Missense 38 7:55205393-55205393 + - PATHOGENIC .98342 Confirmed somatic variant 24807215 surgery fresh/frozen primary 75 ENSP00000395243.3:p.Glu1092Lys ENST00000454757.6:c.3274G>A 7:g.55205393G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1165893 1165893 1078207 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51785733 COSM28575 132575807 c.2515G>A p.E839K Substitution - Missense het 38 7:55192790-55192790 + - PATHOGENIC .9655 Confirmed somatic variant 16407879 cerebrospinal fluid metastasis 70 ENSP00000395243.3:p.Glu839Lys ENST00000454757.6:c.2515G>A 7:g.55192790G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876616 2876616 2731131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105110312 COSM9869917 133238641 c.2017C>G p.L673V Substitution - Missense 38 7:55174011-55174011 + Yes PATHOGENIC .92276 Confirmed somatic variant 29506987 surgery fresh/frozen NS 76 ENSP00000415559.1:p.Leu673Val ENST00000455089.5:c.2017C>G 7:g.55174011C>G EGFR ENST00000275493.6 3633 3236 1498505 1498505 1421383 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 21040950 surgery fresh/frozen primary ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1091702 1091702 1006524 lung NS NS NS carcinoma undifferentiated_carcinoma NS NS n COSM26130 178380894 c.? p.L861P Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PM02M 2653318 2513445 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS metastasis 75.8 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004328-T02-IM5 2720735 2579556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004328-T01-IM5 2720736 2579557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 YUROG 2439363 2302204 skin NS NS NS malignant_melanoma NS NS NS y COSV51803218 COSM5407729 133277066 c.2272C>T p.R758W Substitution - Missense het 38 7:55181416-55181416 + - PATHOGENIC .85795 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 58 ENSP00000415559.1:p.Arg758Trp ENST00000455089.5:c.2272C>T 7:g.55181416C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1165893 1165893 1078207 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16407879 cerebrospinal fluid metastasis 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 494 898391 816003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458700 1458700 1382675 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876062 2876062 2730577 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A102-T-S37 2757415 2616002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0001215-T01-IM3 2716848 2575669 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51857792 COSM6915600 99379720 c.3620T>G p.F1207C Substitution - Missense het 38 7:55205604-55205604 + - PATHOGENIC .74607 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Phe1207Cys ENST00000275493.6:c.3620T>G 7:g.55205604T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005943-T01-IM5 2829924 2685739 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51829196 COSM6947106 132561496 c.3068G>A p.R1023Q Substitution - Missense 38 7:55202557-55202557 + - PATHOGENIC .97786 Confirmed somatic variant 30205045 surgery-fixed metastasis 41 ENSP00000395243.3:p.Arg1023Gln ENST00000454757.6:c.3068G>A 7:g.55202557G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011029-T02-IM5 2726667 2585488 skin mucosal vagina NS malignant_melanoma NS NS NS n COSV51814016 COSM6978576 132555558 c.3113A>G p.D1038G Substitution - Missense het 38 7:55202602-55202602 + - PATHOGENIC .96122 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Asp1038Gly ENST00000454757.6:c.3113A>G 7:g.55202602A>G EGFR ENST00000275493.6 3633 3236 TCGA-AX-A0J1-01 1783377 1687376 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99293276 COSM8941767 99405613 c.3458G>A p.S1153N Substitution - Missense 38 7:55205442-55205442 + - NEUTRAL .25647 Confirmed somatic variant 419 fresh/frozen - NOS primary 80 ENSP00000275493.2:p.Ser1153Asn ENST00000275493.6:c.3458G>A 7:g.55205442G>A EGFR ENST00000275493.6 3633 3236 1091702 1091702 1006524 lung NS NS NS carcinoma undifferentiated_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1113159 1113159 1026660 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 18450321 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 29 2605250 2466141 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 25376516 surgery - NOS NS 81 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2115522 2115522 1989766 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1010428 1010428 927602 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 17001163 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-VS083-T1 2869916 2724913 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51776967 COSM6963220 133218398 c.1795C>T p.P599S Substitution - Missense 38 7:55172993-55172993 + - PATHOGENIC .96242 Confirmed somatic variant 26950094 surgery - NOS NS 72 ENSP00000415559.1:p.Pro599Ser ENST00000455089.5:c.1795C>T 7:g.55172993C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 M702PT 2671818 2531377 pleura NS NS NS mesothelioma epithelial NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26928227 surgery fresh/frozen primary 30 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 XHDG25 2306032 2171303 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV51811244 COSM4767521 132551866 c.472G>A p.G158R Substitution - Missense 38 7:55151341-55151341 + - PATHOGENIC .99471 Confirmed somatic variant 24997986 NS NS ENSP00000395243.3:p.Gly158Arg ENST00000454757.6:c.472G>A 7:g.55151341G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004650-T01-IM5 2721049 2579870 NS NS NS NS malignant_melanoma NS NS NS n COSV51781521 COSM6912042 133258793 c.2920C>T p.P974S Substitution - Missense het 38 7:55201296-55201296 + - PATHOGENIC .99234 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Pro974Ser ENST00000455089.5:c.2920C>T 7:g.55201296C>T EGFR ENST00000275493.6 3633 3236 2901988 2901988 2756229 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1031893 1031893 948684 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17085664 NS metastasis 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471547 1471547 1395286 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1790523 1790523 1693502 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1109725 1109725 1023635 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 53 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 WD_09 2688643 2547625 skin hand NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51780206 COSM12373 133208468 c.2024C>T p.S675F Substitution - Missense het 38 7:55174018-55174018 + - PATHOGENIC .9768 Confirmed somatic variant 24662767 surgery fresh/frozen NS 58 ENSP00000415559.1:p.Ser675Phe ENST00000455089.5:c.2024C>T 7:g.55174018C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003317-T02-IM5 2719811 2578632 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008744-T01-IM5 2724793 2583614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152794 2152794 2021804 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206745 1206745 1118623 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1468626 1468626 1392377 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1087335 1087335 1002313 lung right_upper_lobe NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 17898810 surgery - NOS primary 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 DUMC-05 2748702 2607405 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 29802247 surgery fresh/frozen NS 51 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S001094 1027685 944661 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 P-0004795-T01-IM5 2721198 2580019 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS n COSV51783428 COSM6848064 99390890 c.2930G>A p.R977H Substitution - Missense het 38 7:55200397-55200397 + - PATHOGENIC .99379 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Arg977His ENST00000275493.6:c.2930G>A 7:g.55200397G>A EGFR ENST00000275493.6 3633 3236 982787 982787 898506 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766331 COSM12366 99418284 c.2572C>A p.L858M Substitution - Missense 38 7:55191821-55191821 + - PATHOGENIC .93782 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Met ENST00000275493.6:c.2572C>A 7:g.55191821C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 238 2131812 2005876 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 23619168 fresh/frozen - NOS NS 50 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801748 COSM3923814 133255895 c.2665C>T p.P889S Substitution - Missense 38 7:55198815-55198815 + - PATHOGENIC .94851 Confirmed somatic variant 540 NS NS 68 ENSP00000415559.1:p.Pro889Ser ENST00000455089.5:c.2665C>T 7:g.55198815C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-E5-A2PC-01 1898110 1786794 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51779680 COSM1313184 132574162 c.1016C>G p.T339S Substitution - Missense 38 7:55156776-55156776 + - PATHOGENIC .98418 Confirmed somatic variant 413 fresh/frozen - NOS primary 61 ENSP00000395243.3:p.Thr339Ser ENST00000454757.6:c.1016C>G 7:g.55156776C>G EGFR ENST00000275493.6 3633 3236 P-0002998-T01-IM3 2719207 2578028 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51805664 COSM6925533 99434978 c.1783T>G p.C595G Substitution - Missense het 38 7:55165340-55165340 + - PATHOGENIC .9957 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Cys595Gly ENST00000275493.6:c.1783T>G 7:g.55165340T>G ZBED4 ENST00000216268.5 3516 20721 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105863259 COSM10012948 98072721 c.2831G>T p.S944I Substitution - Missense 38 22:49886493-49886493 + - PATHOGENIC .95528 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000216268.4:p.Ser944Ile ENST00000216268.5:c.2831G>T 22:g.49886493G>T EGFR ENST00000275493.6 3633 3236 P-0011029-T02-IM5 2726667 2585488 skin mucosal vagina NS malignant_melanoma NS NS NS n COSV51814016 COSM6978576 99382835 c.3248A>G p.D1083G Substitution - Missense het 38 7:55202602-55202602 + - PATHOGENIC .96122 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Asp1083Gly ENST00000275493.6:c.3248A>G 7:g.55202602A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EXTERN_MELA_20140924_067 2839387 2695153 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV104577161 COSM9392986 133254055 c.1309G>A p.G437R Substitution - Missense 38 7:55160284-55160284 + - PATHOGENIC .93959 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000415559.1:p.Gly437Arg ENST00000455089.5:c.1309G>A 7:g.55160284G>A EGFR ENST00000275493.6 3633 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801748 COSM3923814 99432416 c.2800C>T p.P934S Substitution - Missense 38 7:55198815-55198815 + - PATHOGENIC .94851 Confirmed somatic variant 540 NS NS 68 ENSP00000275493.2:p.Pro934Ser ENST00000275493.6:c.2800C>T 7:g.55198815C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 16668 1423695 1333723 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790297 COSM48317 133260481 c.406C>A p.P136T Substitution - Missense het 38 7:55143470-55143470 + - PATHOGENIC .9933 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Pro136Thr ENST00000455089.5:c.406C>A 7:g.55143470C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 IGC-04-1052 2662293 2522417 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 HUB-02-B2-042 2607096 2466810 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51802097 COSM6047686 132596047 c.299C>A p.P100H Substitution - Missense 38 7:55143363-55143363 + - PATHOGENIC .9585 Confirmed somatic variant 670 organoid culture NS ENSP00000395243.3:p.Pro100His ENST00000454757.6:c.299C>A 7:g.55143363C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AC-A23H-01 2187848 2056126 breast NS NS NS carcinoma NS NS NS y COSV51765875 COSM3833029 132574962 c.3016G>A p.D1006N Substitution - Missense 38 7:55201771-55201771 + - NEUTRAL .4855 Confirmed somatic variant 414 NS NS 90 ENSP00000395243.3:p.Asp1006Asn ENST00000454757.6:c.3016G>A 7:g.55201771G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812078 2812078 2668549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51776947 COSM6910370 132564250 c.2362T>A p.L788M Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .36784 Confirmed somatic variant 31534501 pleural effusion NS 72 ENSP00000395243.3:p.Leu788Met ENST00000454757.6:c.2362T>A 7:g.55191746T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-S9-A6WN-01 2263420 2130404 central_nervous_system brain NS NS glioma NS NS NS y COSV99292726 COSM8266258 133230592 c.2537A>G p.Y846C Substitution - Missense 38 7:55192812-55192812 + - PATHOGENIC .89661 Confirmed somatic variant 545 NS primary 38 ENSP00000415559.1:p.Tyr846Cys ENST00000455089.5:c.2537A>G 7:g.55192812A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005337-T01-IM5 2721741 2580562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008577-T01-IM5 2724677 2583498 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CTS21 2393074 2255905 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A017-T-S11 2757376 2615994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 56 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1179549 1179549 1091511 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A001-T-S01 2757354 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489261 1489261 1412419 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 55 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-27-2528-01 1338071 1248456 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 surgery fresh/frozen NS 62 ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 16668 1423695 1333723 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790297 COSM48317 99437584 c.406C>A p.P136T Substitution - Missense het 38 7:55143470-55143470 + - PATHOGENIC .9933 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Pro136Thr ENST00000275493.6:c.406C>A 7:g.55143470C>A EGFR ENST00000275493.6 3633 3236 EXTERN_MELA_20140924_067 2839387 2695153 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV104577161 COSM9392986 99430658 c.1444G>A p.G482R Substitution - Missense 38 7:55160284-55160284 + - PATHOGENIC .93959 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000275493.2:p.Gly482Arg ENST00000275493.6:c.1444G>A 7:g.55160284G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004795-T01-IM5 2721198 2580019 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS n COSV51783428 COSM6848064 133218554 c.2795G>A p.R932H Substitution - Missense het 38 7:55200397-55200397 + - PATHOGENIC .99379 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Arg932His ENST00000455089.5:c.2795G>A 7:g.55200397G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MaPT10 2491641 2354282 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1690853 1690853 1599120 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 133216830 c.1341C>A p.S447R Substitution - Missense 38 7:55160316-55160316 + - NEUTRAL .35843 Confirmed somatic variant 22270724 surgery - NOS recurrent 52 ENSP00000415559.1:p.Ser447Arg ENST00000455089.5:c.1341C>A 7:g.55160316C>A EGFR ENST00000275493.6 3633 3236 TCGA-GM-A2DD-01 2187736 2056014 breast NS NS NS carcinoma NS NS NS y COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 414 NS NS 53 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 P-0004066-T01-IM5 2720468 2579289 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 P-0007319-T01-IM5 2723658 2582479 penis NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51785510 COSM6957413 99373603 c.1102G>A p.D368N Substitution - Missense het 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Asp368Asn ENST00000275493.6:c.1102G>A 7:g.55156628G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-28-1749-01 2178174 2046472 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 132560457 c.953C>T p.T318I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 NS NS 73 ENSP00000395243.3:p.Thr318Ile ENST00000454757.6:c.953C>T 7:g.55156614C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SJALL040461-D 2824035 2679863 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV104576718 COSM9280424 132560587 c.1457G>A p.R486Q Substitution - Missense 38 7:55161592-55161592 + - PATHOGENIC .99386 Confirmed somatic variant 31697823 blood-bone marrow NS 11.64 ENSP00000395243.3:p.Arg486Gln ENST00000454757.6:c.1457G>A 7:g.55161592G>A EGFR ENST00000275493.6 3633 3236 Br213T 1313043 1223952 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 surgery - NOS primary 71 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-28-5213-01 2120336 1994572 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 72 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 T578 2296255 2161858 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51788796 COSM4680390 99401501 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 25344691 NS NS 61.08 ENSP00000275493.2:p.Arg98Gln ENST00000275493.6:c.293G>A 7:g.55143357G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-28-5213-01 2120336 1994572 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 72 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 2591397 2591397 2452357 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2675074 2675074 2534349 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 29110836 surgery-fixed recurrent 37 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2115537 2115537 1989781 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 TCGA-14-0866-01 2178121 2046419 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99295486 COSM7482458 99402649 c.1139C>T p.S380F Substitution - Missense 38 7:55156764-55156764 + - NEUTRAL .25937 Confirmed somatic variant 329 NS NS 55 ENSP00000275493.2:p.Ser380Phe ENST00000275493.6:c.1139C>T 7:g.55156764C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Br229T 1313048 1223957 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51848573 COSM39565 132578013 c.796T>A p.C266S Substitution - Missense het 38 7:55155871-55155871 + - PATHOGENIC .98855 Confirmed somatic variant 18772396 surgery - NOS primary 28 ENSP00000395243.3:p.Cys266Ser ENST00000454757.6:c.796T>A 7:g.55155871T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T578 2658233 2518392 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51788796 COSM4680390 132569555 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 27149842 NS NS 61.08 ENSP00000395243.3:p.Arg98Gln ENST00000454757.6:c.293G>A 7:g.55143357G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Br229T 1313048 1223957 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51848573 COSM39565 133238176 c.796T>A p.C266S Substitution - Missense het 38 7:55155871-55155871 + - PATHOGENIC .98855 Confirmed somatic variant 18772396 surgery - NOS primary 28 ENSP00000415559.1:p.Cys266Ser ENST00000455089.5:c.796T>A 7:g.55155871T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DI-A1BU-01 2198300 2066578 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99287849 COSM8863291 133228974 c.1531A>G p.I511V Substitution - Missense 38 7:55163767-55163767 + - NEUTRAL .09266 Confirmed somatic variant 419 NS NS 55 ENSP00000415559.1:p.Ile511Val ENST00000455089.5:c.1531A>G 7:g.55163767A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51865345 COSM6970489 132611821 c.1042G>A p.D348N Substitution - Missense het 38 7:55156802-55156802 + - PATHOGENIC .91392 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Asp348Asn ENST00000454757.6:c.1042G>A 7:g.55156802G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SK-MEL-28 1998476 1883548 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm hairy_cell_leukaemia NS NS y COSV51778029 COSM6268 132554063 c.2122C>T p.P708S Substitution - Missense hom 38 7:55174794-55174794 + - PATHOGENIC .98527 Confirmed somatic variant 23856246 cell-line primary ENSP00000395243.3:p.Pro708Ser ENST00000454757.6:c.2122C>T 7:g.55174794C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007842-T01-IM5 2724054 2582875 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-14-0866-01 2178121 2046419 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99295486 COSM7482458 132570661 c.1004C>T p.S335F Substitution - Missense 38 7:55156764-55156764 + - NEUTRAL .25937 Confirmed somatic variant 329 NS NS 55 ENSP00000395243.3:p.Ser335Phe ENST00000454757.6:c.1004C>T 7:g.55156764C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003783-T01-IM5 2720274 2579095 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0749 2107988 1985849 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 TCGA-DI-A1BU-01 2198300 2066578 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99287857 COSM9051280 99403204 c.3281A>G p.N1094S Substitution - Missense 38 7:55205265-55205265 + - PATHOGENIC .98005 Confirmed somatic variant 419 NS NS 55 ENSP00000275493.2:p.Asn1094Ser ENST00000275493.6:c.3281A>G 7:g.55205265A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0174-01 1910190 1798481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51773690 COSM3412198 132602232 c.1706G>A p.G569D Substitution - Missense 38 7:55165398-55165398 + - NEUTRAL .00947 Confirmed somatic variant 329 fresh/frozen - NOS primary 54 ENSP00000395243.3:p.Gly569Asp ENST00000454757.6:c.1706G>A 7:g.55165398G>A EGFR ENST00000275493.6 3633 3236 7T 2473854 2336624 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51794834 COSM5575633 99386191 c.2873G>A p.R958H Substitution - Missense 38 7:55200340-55200340 + - PATHOGENIC .99504 Confirmed somatic variant 26489445 fixed - NOS NS ENSP00000275493.2:p.Arg958His ENST00000275493.6:c.2873G>A 7:g.55200340G>A EGFR ENST00000275493.6 3633 3236 EOSRC-IN-2785 2902114 2756352 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV105864249 COSM9977627 99425685 c.2411A>T p.E804V Substitution - Missense 38 7:55181420-55181420 + - PATHOGENIC .97936 Confirmed somatic variant 33262464 surgery - NOS NS 55 ENSP00000275493.2:p.Glu804Val ENST00000275493.6:c.2411A>T 7:g.55181420A>T EGFR ENST00000275493.6 3633 3236 3101B7_035_T 2390296 2253128 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51811266 COSM5041204 99407267 c.385A>G p.K129E Substitution - Missense 38 7:55143449-55143449 + - PATHOGENIC .9498 Confirmed somatic variant 25159915 NS NS ENSP00000275493.2:p.Lys129Glu ENST00000275493.6:c.385A>G 7:g.55143449A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812094 2812094 2668557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 31534501 pleural effusion NS 63 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876610 2876610 2731125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 132551401 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000395243.3:p.Arg731His ENST00000454757.6:c.2192G>A 7:g.55181336G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876034 2876034 2730549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 44 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-06-0876 2107991 1985852 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S07-39193-TP 2366575 2229458 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51792018 COSM4992972 132551365 c.2999C>T p.S1000F Substitution - Missense het 38 7:55201754-55201754 + - PATHOGENIC .97067 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000395243.3:p.Ser1000Phe ENST00000454757.6:c.2999C>T 7:g.55201754C>T EGFR ENST00000275493.6 3633 3236 TCGA-F1-6177-01 2198156 2066434 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51817351 COSM3881830 99397516 c.3092G>A p.R1031Q Substitution - Missense 38 7:55201333-55201333 + - PATHOGENIC .98371 Confirmed somatic variant 541 NS NS 90 ENSP00000275493.2:p.Arg1031Gln ENST00000275493.6:c.3092G>A 7:g.55201333G>A EGFR ENST00000275493.6 3633 3236 YUROC 2439362 2302203 skin NS NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 99383908 c.3025G>A p.D1009N Substitution - Missense het 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 50 ENSP00000275493.2:p.Asp1009Asn ENST00000275493.6:c.3025G>A 7:g.55201266G>A EGFR ENST00000275493.6 3633 3236 2152699 2152699 2021709 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 P-0011543-T01-IM5 2727115 2585936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51806727 COSM6978402 99387873 c.2318_2320delinsTCA p.H773_V774delinsLM Substitution - Missense het 38 7:55181327-55181329 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.His773_Val774delinsLeuMet ENST00000275493.6:c.2318_2320delinsTCA 7:g.55181327_55181329delinsTCA EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LICA-CN-HCC121T 2634168 2494564 liver NS NS NS other neoplasm NS NS y COSV51825459 COSM122789 133214097 c.1288A>G p.I430V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Confirmed somatic variant 660 NS primary 49 ENSP00000415559.1:p.Ile430Val ENST00000455089.5:c.1288A>G 7:g.55160263A>G EGFR ENST00000275493.6 3633 3236 1312394 1312394 1223303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 59 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 7T 2473854 2336624 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51797642 COSM5575634 132569549 c.3284A>G p.N1095S Substitution - Missense 38 7:55205403-55205403 + - PATHOGENIC .97276 Confirmed somatic variant 26489445 fixed - NOS NS ENSP00000395243.3:p.Asn1095Ser ENST00000454757.6:c.3284A>G 7:g.55205403A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011543-T01-IM5 2727115 2585936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51806727 COSM6978402 133215997 c.2183_2185delinsTCA p.H728_V729delinsLM Substitution - Missense het 38 7:55181327-55181329 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.His728_Val729delinsLeuMet ENST00000455089.5:c.2183_2185delinsTCA 7:g.55181327_55181329delinsTCA EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 132563575 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2255G>C 7:g.55181399G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51770694 COSM20891 132562677 c.2251G>A p.G751S Substitution - Missense 38 7:55181395-55181395 + Yes PATHOGENIC .98244 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000395243.3:p.Gly751Ser ENST00000454757.6:c.2251G>A 7:g.55181395G>A EGFR ENST00000275493.6 3633 3236 Br112X 1313001 1223910 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 18772396 xenograft primary 48 ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 P-0007381-T01-IM5 2723717 2582538 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51814979 COSM6957934 99416149 c.1335A>G p.I445M Substitution - Missense het 38 7:55160175-55160175 + - NEUTRAL .42702 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ile445Met ENST00000275493.6:c.1335A>G 7:g.55160175A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007663-T01-IM5 2723937 2582758 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458695 1458695 1382670 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009260-T01-IM5 2725217 2584038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004994 1004994 922206 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008705-T01-IM5 2724760 2583581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914584 914584 832033 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 80 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812090 2812090 2668555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 79 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004328-T01-IM5 2720736 2579557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982856 982856 898575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920021 920021 837100 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471567 1471567 1395306 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811961 2811961 2668496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 78 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003213-T01-IM5 2719708 2578529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211135 1211135 1123003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 53 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 R056-I1 2813481 2669873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289246 COSM8268187 133206444 c.653C>T p.T218I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 28263318 surgery fresh/frozen NS 42 ENSP00000415559.1:p.Thr218Ile ENST00000455089.5:c.653C>T 7:g.55154051C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007084-T02-IM5 2723457 2582278 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51779794 COSM53264 132559797 c.2039C>T p.T680M Substitution - Missense het 38 7:55174033-55174033 + - PATHOGENIC .97744 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr680Met ENST00000454757.6:c.2039C>T 7:g.55174033C>T EGFR ENST00000275493.6 3633 3236 GB066T 2634031 2494427 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51808309 COSM6355435 99393433 c.3550A>G p.N1184D Substitution - Missense 38 7:55205534-55205534 + - PATHOGENIC .97599 Confirmed somatic variant 672 NS primary ENSP00000275493.2:p.Asn1184Asp ENST00000275493.6:c.3550A>G 7:g.55205534A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812097 2812097 2668558 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 circulating tumour NS 78 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S_TBL200_R5 2757769 2616343 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29106415 autopsy - NOS metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876034 2876034 2730549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 133216269 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour recurrent 44 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2254T>A 7:g.55181398T>A EGFR ENST00000275493.6 3633 3236 WD_09 2688643 2547625 skin hand NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51780206 COSM12373 99380273 c.2159C>T p.S720F Substitution - Missense het 38 7:55174018-55174018 + - PATHOGENIC .9768 Confirmed somatic variant 24662767 surgery fresh/frozen NS 58 ENSP00000275493.2:p.Ser720Phe ENST00000275493.6:c.2159C>T 7:g.55174018C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DUMC-05 2748702 2607405 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 29802247 surgery fresh/frozen NS 51 ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876034 2876034 2730549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 133219834 c.2239C>T p.L747F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour recurrent 44 ENSP00000415559.1:p.Leu747Phe ENST00000455089.5:c.2239C>T 7:g.55181383C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 133219834 c.2239C>T p.L747F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000415559.1:p.Leu747Phe ENST00000455089.5:c.2239C>T 7:g.55181383C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-CA-5254-01 1651181 1565968 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV99289896 COSM7552012 132588132 c.2881G>A p.D961N Substitution - Missense 38 7:55201257-55201257 + - PATHOGENIC .98884 Confirmed somatic variant 376 NS NS 42 ENSP00000395243.3:p.Asp961Asn ENST00000454757.6:c.2881G>A 7:g.55201257G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-E5-A2PC-01 1898110 1786794 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51779680 COSM1313184 133232489 c.1016C>G p.T339S Substitution - Missense 38 7:55156776-55156776 + - PATHOGENIC .98418 Confirmed somatic variant 413 fresh/frozen - NOS primary 61 ENSP00000415559.1:p.Thr339Ser ENST00000455089.5:c.1016C>G 7:g.55156776C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 133219858 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2255G>C 7:g.55181399G>C EGFR ENST00000275493.6 3633 3236 2862443 2862443 2717611 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM9609403 178387249 c.? p.G632A Substitution - Missense + - Confirmed somatic variant 31694833 surgery-fixed metastasis 82 ENSP00000275493.2:p.Gly632Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876034 2876034 2730549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832145 COSM6493936 133233446 c.2254T>G p.C752G Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95801 Confirmed somatic variant 29506987 circulating tumour recurrent 44 ENSP00000415559.1:p.Cys752Gly ENST00000455089.5:c.2254T>G 7:g.55181398T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000348-T01-IM3 2715088 2573909 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 133205309 c.2104_2105delinsCC p.L702P Substitution - Missense het 38 7:55174776-55174777 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu702Pro ENST00000455089.5:c.2104_2105delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000454757 ENST00000454757.6 3498 3236 279 2748251 2606954 stomach NS NS NS carcinoma NS NS NS y COSV99290218 COSM8504937 132606489 c.3455A>G p.Y1152C Substitution - Missense 38 7:55205574-55205574 + - PATHOGENIC .97561 Confirmed somatic variant 683 NS primary ENSP00000395243.3:p.Tyr1152Cys ENST00000454757.6:c.3455A>G 7:g.55205574A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801757 COSM3923815 133255901 c.2737C>T p.R913C Substitution - Missense 38 7:55200339-55200339 + - PATHOGENIC .97155 Confirmed somatic variant 540 NS NS 68 ENSP00000415559.1:p.Arg913Cys ENST00000455089.5:c.2737C>T 7:g.55200339C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008215-T01-IM5 2830122 2685937 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51834499 COSM6845063 133203949 c.829G>A p.G277S Substitution - Missense 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 30205045 surgery-fixed primary 58 ENSP00000415559.1:p.Gly277Ser ENST00000455089.5:c.829G>A 7:g.55155904G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 10677523 2751151 2609847 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV105822269 COSM9522392 132567679 c.871G>C p.V291L Substitution - Missense 38 7:55155946-55155946 + - Confirmed somatic variant 29748005 circulating tumour NS ENSP00000395243.3:p.Val291Leu ENST00000454757.6:c.871G>C 7:g.55155946G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787534 COSM6191454 132549759 c.940T>C p.F314L Substitution - Missense 38 7:55156601-55156601 + - PATHOGENIC .99231 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000395243.3:p.Phe314Leu ENST00000454757.6:c.940T>C 7:g.55156601T>C EGFR ENST00000275493.6 3633 3236 1040349 1040349 956926 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_II NS NS n COSV51790148 COSM22555 99381470 c.2030G>A p.R677H Substitution - Missense 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000275493.2:p.Arg677His ENST00000275493.6:c.2030G>A 7:g.55173093G>A EGFR ENST00000275493.6 3633 3236 P-0000435-T01-IM3 2786865 2644288 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51776947 COSM6910370 99393548 c.2497T>A p.L833M Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .36784 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000275493.2:p.Leu833Met ENST00000275493.6:c.2497T>A 7:g.55191746T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009243-T01-IM5 2725202 2584023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51826157 COSM6967746 132622330 c.3188C>G p.P1063R Substitution - Missense het 38 7:55205307-55205307 + - PATHOGENIC .93931 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000395243.3:p.Pro1063Arg ENST00000454757.6:c.3188C>G 7:g.55205307C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002649-T01-IM3 2718895 2577716 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51794834 COSM5575633 132558496 c.2738G>A p.R913H Substitution - Missense het 38 7:55200340-55200340 + - PATHOGENIC .99504 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg913His ENST00000454757.6:c.2738G>A 7:g.55200340G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787865 COSM6191461 132549774 c.3389A>T p.D1130V Substitution - Missense 38 7:55205508-55205508 + - PATHOGENIC .89387 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000395243.3:p.Asp1130Val ENST00000454757.6:c.3389A>T 7:g.55205508A>T EGFR ENST00000275493.6 3633 3236 R056-I1 2813481 2669873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289246 COSM8268187 99378347 c.788C>T p.T263I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 28263318 surgery fresh/frozen NS 42 ENSP00000275493.2:p.Thr263Ile ENST00000275493.6:c.788C>T 7:g.55154051C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004066-T01-IM5 2720468 2579289 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 367-66 2605259 2466150 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 25376516 surgery - NOS NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-AD-6964-01 1651148 1565935 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51773844 COSM1451620 99425810 c.3289G>A p.V1097I Substitution - Missense 38 7:55205273-55205273 + - NEUTRAL .13302 Confirmed somatic variant 376 NS NS 58 ENSP00000275493.2:p.Val1097Ile ENST00000275493.6:c.3289G>A 7:g.55205273G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471563 1471563 1395302 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 TCGA-32-1970-01 1338089 1248474 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1194732 1194732 1106627 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206718 1206718 1118596 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876616 2876616 2731131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 surgery fresh/frozen NS 76 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008744-T02-IM5 2724794 2583615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1179551 1179551 1091513 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 55 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471534 1471534 1395273 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982850 982850 898569 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489255 1489255 1412413 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007084-T02-IM5 2723457 2582278 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51797839 COSM6958991 133240656 c.37G>A p.A13T Substitution - Missense het 38 7:55019314-55019314 + - NEUTRAL .01885 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ala13Thr ENST00000455089.5:c.37G>A 7:g.55019314G>A EGFR ENST00000275493.6 3633 3236 P-0007842-T01-IM5 2724054 2582875 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982787 982787 898506 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766331 COSM12366 133243522 c.2437C>A p.L813M Substitution - Missense 38 7:55191821-55191821 + - PATHOGENIC .93782 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Met ENST00000455089.5:c.2437C>A 7:g.55191821C>A EGFR ENST00000275493.6 3633 3236 1498504 1498504 1421382 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Confirmed somatic variant 21040950 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625912 2625912 2486324 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51840660 COSM6191463 132565784 c.3428A>C p.K1143T Substitution - Missense 38 7:55205547-55205547 + - PATHOGENIC .7653 Confirmed somatic variant 25617745 surgery-fixed NS 66 ENSP00000395243.3:p.Lys1143Thr ENST00000454757.6:c.3428A>C 7:g.55205547A>C EGFR ENST00000275493.6 3633 3236 5-RSII 2060462 1940669 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma Richter_transformation NS y COSV51773206 COSM28603 99389206 c.2293G>A p.V765M Substitution - Missense 38 7:55181302-55181302 + - PATHOGENIC .97963 Confirmed somatic variant 24127483 blood-bone marrow primary 70 ENSP00000275493.2:p.Val765Met ENST00000275493.6:c.2293G>A 7:g.55181302G>A EGFR ENST00000275493.6 3633 3236 TCGA-KK-A59Y-01 2340238 2205221 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51814881 COSM3929116 99399609 c.934G>T p.G312W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 435 NS primary 56 ENSP00000275493.2:p.Gly312Trp ENST00000275493.6:c.934G>T 7:g.55155874G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002091-T02-IM5 2719479 2578300 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1179730 1179730 1091692 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 19096324 NS primary 62 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006105-T01-IM5 2722481 2581302 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812096 2812096 2668558 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 pleural effusion NS 78 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211138 1211138 1123006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 85 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004650-T01-IM5 2721049 2579870 NS NS NS NS malignant_melanoma NS NS NS n COSV51781521 COSM6912042 132595592 c.2920C>T p.P974S Substitution - Missense het 38 7:55201296-55201296 + - PATHOGENIC .99234 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Pro974Ser ENST00000454757.6:c.2920C>T 7:g.55201296C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1113112 1113112 1026613 thymus NS NS NS thymoma NS NS NS n COSV51778659 COSM14070 132547729 c.2453G>A p.G818D Substitution - Missense het 38 7:55191837-55191837 + - PATHOGENIC .92688 Confirmed somatic variant 18448188 surgery-fixed NS 69 ENSP00000395243.3:p.Gly818Asp ENST00000454757.6:c.2453G>A 7:g.55191837G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EXTERN_MELA_20140924_131 2839485 2695251 skin scalp NS NS malignant_melanoma NS NS NS y COSV51806564 COSM6920868 132555861 c.1871G>A p.R624Q Substitution - Missense 38 7:55173069-55173069 + - PATHOGENIC .99699 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000395243.3:p.Arg624Gln ENST00000454757.6:c.1871G>A 7:g.55173069G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV51769815 COSM249886 132571782 c.1961C>T p.P654L Substitution - Missense 38 7:55173955-55173955 + - PATHOGENIC .97389 Confirmed somatic variant 540 NS NS 90 ENSP00000395243.3:p.Pro654Leu ENST00000454757.6:c.1961C>T 7:g.55173955C>T EGFR ENST00000275493.6 3633 3236 1031893 1031893 948684 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 99396060 c.2281G>T p.D761Y Substitution - Missense het 38 7:55174818-55174818 + Yes PATHOGENIC .99554 Confirmed somatic variant 17085664 NS metastasis 72 ENSP00000275493.2:p.Asp761Tyr ENST00000275493.6:c.2281G>T 7:g.55174818G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CRC334 2730827 2589596 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51767379 COSM85894 133213549 c.2392G>A p.V798I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 26416732 xenograft metastasis 65 ENSP00000415559.1:p.Val798Ile ENST00000455089.5:c.2392G>A 7:g.55191776G>A EGFR ENST00000275493.6 3633 3236 2862445 2862445 2717612 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM9609404 178378378 c.? p.D1009N Substitution - Missense + - Confirmed somatic variant 31694833 surgery-fixed primary 67 ENSP00000275493.2:p.Asp1009Asn EGFR ENST00000275493.6 3633 3236 Br229T 1313048 1223957 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51848573 COSM39565 99411590 c.931T>A p.C311S Substitution - Missense het 38 7:55155871-55155871 + - PATHOGENIC .98855 Confirmed somatic variant 18772396 surgery - NOS primary 28 ENSP00000275493.2:p.Cys311Ser ENST00000275493.6:c.931T>A 7:g.55155871T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DUMC-05 2748702 2607405 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 29802247 surgery fresh/frozen NS 51 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 P-0001278-T01-IM3 2716974 2575795 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51844468 COSM6916179 99399830 c.308A>T p.N103I Substitution - Missense het 38 7:55143372-55143372 + - PATHOGENIC .97828 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Asn103Ile ENST00000275493.6:c.308A>T 7:g.55143372A>T EGFR ENST00000275493.6 3633 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766880 COSM28516 99392483 c.2404G>T p.V802F Substitution - Missense 38 7:55181413-55181413 + - PATHOGENIC .89385 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000275493.2:p.Val802Phe ENST00000275493.6:c.2404G>T 7:g.55181413G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005076-T01-IM5 2721479 2580300 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51785733 COSM28575 132575807 c.2515G>A p.E839K Substitution - Missense het 38 7:55192790-55192790 + - PATHOGENIC .9655 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Glu839Lys ENST00000454757.6:c.2515G>A 7:g.55192790G>A EGFR ENST00000275493.6 3633 3236 2591465 2591465 2452425 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 TCGA-BR-6452-01 2197940 2066218 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51804028 COSM3881820 99386777 c.1507G>T p.G503C Substitution - Missense 38 7:55161507-55161507 + - NEUTRAL .38516 Confirmed somatic variant 541 NS NS 78 ENSP00000275493.2:p.Gly503Cys ENST00000275493.6:c.1507G>T 7:g.55161507G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T578 2296255 2161858 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51788796 COSM4680390 133226922 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 25344691 NS NS 61.08 ENSP00000415559.1:p.Arg98Gln ENST00000455089.5:c.293G>A 7:g.55143357G>A KIAA1549 ENST00000422774.1 5853 22219 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105841100 COSM10012915 122930982 c.2213C>T p.T738M Substitution - Missense 38 7:138917413-138917413 - - NEUTRAL .05255 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000416040.1:p.Thr738Met ENST00000422774.1:c.2213C>T 7:g.138917413G>A EGFR ENST00000275493.6 3633 3236 P-0004328-T01-IM5 2720736 2579557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876608 2876608 2731123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 132563558 c.2239C>T p.L747F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour NS ENSP00000395243.3:p.Leu747Phe ENST00000454757.6:c.2239C>T 7:g.55181383C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152774 2152774 2021784 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982885 982885 898604 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 16786 1423727 1333755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-EJ-5495-01 1797184 1698931 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51809907 COSM1131542 99402542 c.3554G>T p.G1185V Substitution - Missense 38 7:55205538-55205538 + - PATHOGENIC .94469 Confirmed somatic variant 435 fresh/frozen - NOS primary 68 ENSP00000275493.2:p.Gly1185Val ENST00000275493.6:c.3554G>T 7:g.55205538G>T EGFR ENST00000275493.6 3633 3236 2150418 2150418 2019487 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 58 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008179-T01-IM5 2724346 2583167 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 133209185 c.1639G>A p.V547I Substitution - Missense het 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Val547Ile ENST00000455089.5:c.1639G>A 7:g.55165331G>A EGFR ENST00000275493.6 3633 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 YUROC 2439362 2302203 skin NS NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 132556505 c.2890G>A p.D964N Substitution - Missense het 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 50 ENSP00000395243.3:p.Asp964Asn ENST00000454757.6:c.2890G>A 7:g.55201266G>A EGFR ENST00000275493.6 3633 3236 2812094 2812094 2668557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 99378223 c.2327G>A p.R776H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Confirmed somatic variant 31534501 pleural effusion NS 63 ENSP00000275493.2:p.Arg776His ENST00000275493.6:c.2327G>A 7:g.55181336G>A EGFR ENST00000275493.6 3633 3236 PD7043a 1504254 1427132 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia NS n COSV51852469 COSM4384119 99379887 c.1417A>G p.N473D Substitution - Missense 38 7:55160257-55160257 + - NEUTRAL .3314 Confirmed somatic variant 24030381 NS NS ENSP00000275493.2:p.Asn473Asp ENST00000275493.6:c.1417A>G 7:g.55160257A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002998-T01-IM3 2719207 2578028 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51805664 COSM6925533 133258058 c.1648T>G p.C550G Substitution - Missense het 38 7:55165340-55165340 + - PATHOGENIC .9957 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Cys550Gly ENST00000455089.5:c.1648T>G 7:g.55165340T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EXTERN_MELA_20140924_001 2839320 2695086 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51781835 COSM174732 132552286 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28467829 cell-line metastasis ENSP00000395243.3:p.Glu114Lys ENST00000454757.6:c.340G>A 7:g.55143404G>A EGFR ENST00000275493.6 3633 3236 P-0007100-T01-IM5 2830046 2685861 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51776957 COSM6955986 99424823 c.3121A>G p.T1041A Substitution - Missense 38 7:55201741-55201741 + - PATHOGENIC .92147 Confirmed somatic variant 30205045 surgery-fixed primary 50 ENSP00000275493.2:p.Thr1041Ala ENST00000275493.6:c.3121A>G 7:g.55201741A>G EGFR ENST00000275493.6 3633 3236 1498504 1498504 1421382 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Confirmed somatic variant 21040950 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914567 914567 832016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 15788655 surgery fresh/frozen primary 83 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008145-T02-IM5 2724310 2583131 breast NS NS NS carcinoma NS NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 GYWU_534 2771325 2629517 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV99291764 COSM7410245 99388167 c.2944C>A p.Q982K Substitution - Missense 38 7:55200411-55200411 + - PATHOGENIC .99148 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000275493.2:p.Gln982Lys ENST00000275493.6:c.2944C>A 7:g.55200411C>A EGFR ENST00000275493.6 3633 3236 TCGA-DI-A1BU-01 2198300 2066578 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99287849 COSM8863291 99403184 c.1666A>G p.I556V Substitution - Missense 38 7:55163767-55163767 + - NEUTRAL .09266 Confirmed somatic variant 419 NS NS 55 ENSP00000275493.2:p.Ile556Val ENST00000275493.6:c.1666A>G 7:g.55163767A>G EGFR ENST00000275493.6 3633 3236 TCGA-AC-A23H-01 2187848 2056126 breast NS NS NS carcinoma NS NS NS y COSV51765875 COSM3833029 99407066 c.3151G>A p.D1051N Substitution - Missense 38 7:55201771-55201771 + - NEUTRAL .4855 Confirmed somatic variant 414 NS NS 90 ENSP00000275493.2:p.Asp1051Asn ENST00000275493.6:c.3151G>A 7:g.55201771G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004328-T02-IM5 2720735 2579556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460138 1460138 1384015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 132549396 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000395243.3:p.Pro803Leu ENST00000454757.6:c.2408C>T 7:g.55191792C>T EGFR ENST00000275493.6 3633 3236 HUB-02-B2-042 2607096 2466810 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51802097 COSM6047686 99436429 c.299C>A p.P100H Substitution - Missense 38 7:55143363-55143363 + - PATHOGENIC .9585 Confirmed somatic variant 670 organoid culture NS ENSP00000275493.2:p.Pro100His ENST00000275493.6:c.299C>A 7:g.55143363C>A EGFR ENST00000275493.6 3633 3236 TCGA-76-6656-01 2120392 1994628 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51857475 COSM3412176 99424053 c.719G>A p.C240Y Substitution - Missense 38 7:55152636-55152636 + - PATHOGENIC .99504 Confirmed somatic variant 329 NS NS 66 ENSP00000275493.2:p.Cys240Tyr ENST00000275493.6:c.719G>A 7:g.55152636G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Br213T 1313043 1223952 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 surgery - NOS primary 71 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-28-1749-01 2178174 2046472 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 133216524 c.953C>T p.T318I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 NS NS 73 ENSP00000415559.1:p.Thr318Ile ENST00000455089.5:c.953C>T 7:g.55156614C>T EGFR ENST00000275493.6 3633 3236 1460148 1460148 1384025 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CH-LA9 2211435 2079638 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24449147 surgery fresh/frozen NS 51 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982879 982879 898598 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 909LC 2637299 2497672 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26503331 surgery fresh/frozen NS 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1005005 1005005 922217 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1211139 1211139 1123007 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19381876 surgery fresh/frozen NS 85 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV51769815 COSM249886 133229603 c.1961C>T p.P654L Substitution - Missense 38 7:55173955-55173955 + - PATHOGENIC .97389 Confirmed somatic variant 540 NS NS 90 ENSP00000415559.1:p.Pro654Leu ENST00000455089.5:c.1961C>T 7:g.55173955C>T EGFR ENST00000275493.6 3633 3236 1211138 1211138 1123006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 85 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2115520 2115520 1989764 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2150418 2150418 2019487 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 58 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1498500 1498500 1421378 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21040950 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2901983 2901983 2756227 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Leu861Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005943-T01-IM5 2829924 2685739 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51829196 COSM6947106 133217667 c.3068G>A p.R1023Q Substitution - Missense 38 7:55202557-55202557 + - PATHOGENIC .97786 Confirmed somatic variant 30205045 surgery-fixed metastasis 41 ENSP00000415559.1:p.Arg1023Gln ENST00000455089.5:c.3068G>A 7:g.55202557G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2665864 2665864 2525572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792237 COSM6842523 133214131 c.694_695delinsGA p.M232E Substitution - Missense het 38 7:55154092-55154093 + - Confirmed somatic variant 28979142 surgery - NOS NS 70 ENSP00000415559.1:p.Met232Glu ENST00000455089.5:c.694_695delinsGA 7:g.55154092_55154093delinsGA EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008285-T01-IM5 2724413 2583234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812093 2812093 2668556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 59 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005000 1005000 922212 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876056 2876056 2730571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 56 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 IGC-11-1112 2662356 2522480 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_C3 1863684 1754575 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 65 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_S25 1863736 1754627 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 78 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 99392449 c.2374C>T p.L792F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000275493.2:p.Leu792Phe ENST00000275493.6:c.2374C>T 7:g.55181383C>T EGFR ENST00000275493.6 3633 3236 2876034 2876034 2730549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 99392449 c.2374C>T p.L792F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour recurrent 44 ENSP00000275493.2:p.Leu792Phe ENST00000275493.6:c.2374C>T 7:g.55181383C>T EGFR ENST00000275493.6 3633 3236 P-0006105-T01-IM5 2722481 2581302 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1179730 1179730 1091692 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 19096324 NS primary 62 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2812096 2812096 2668558 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 pleural effusion NS 78 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0002091-T02-IM5 2719479 2578300 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1211138 1211138 1123006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 85 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 134 897200 814823 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876661 2876661 2731176 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CTS175 2393056 2255887 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 56 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152790 2152790 2021800 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A062-T-S11 2757397 2615999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982853 982853 898572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-13-0912-01 1474988 1398687 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51781835 COSM174732 133207258 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 21720365 331 NS primary 58 ENSP00000415559.1:p.Glu114Lys ENST00000455089.5:c.340G>A 7:g.55143404G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-13-0912-01 1474988 1398687 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51781835 COSM174732 133207258 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 331 NS primary 58 ENSP00000415559.1:p.Glu114Lys ENST00000455089.5:c.340G>A 7:g.55143404G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458690 1458690 1382665 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811978 2811978 2668502 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed NS 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007846-T01-IM5 2724058 2582879 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206715 1206715 1118593 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 pfg413T 2309709 2174911 stomach NS NS NS carcinoma intestinal_adenocarcinoma NS NS y COSV51771306 COSM1318972 132562649 c.1778C>T p.T593M Substitution - Missense het 38 7:55171207-55171207 + - NEUTRAL .03249 Confirmed somatic variant 24816253 surgery fresh/frozen NS 65 ENSP00000395243.3:p.Thr593Met ENST00000454757.6:c.1778C>T 7:g.55171207C>T EGFR ENST00000275493.6 3633 3236 TG88205 2823146 2679000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 28818608 surgery-fixed NS 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468640 1468640 1392391 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 99378725 c.787A>C p.T263P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr263Pro ENST00000275493.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004379-T01-IM5 2720790 2579611 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51857819 COSM6935325 133219642 c.1262A>C p.N421T Substitution - Missense het 38 7:55160237-55160237 + - PATHOGENIC .99346 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Asn421Thr ENST00000455089.5:c.1262A>C 7:g.55160237A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 M702PT 2671818 2531377 pleura NS NS NS mesothelioma epithelial NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26928227 surgery fresh/frozen primary 30 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 TCGA-BP-4341-01 2120462 1994698 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51785438 COSM3366978 99419308 c.2495G>A p.R832H Substitution - Missense 38 7:55191744-55191744 + - PATHOGENIC .9403 Confirmed somatic variant 416 NS NS 67 ENSP00000275493.2:p.Arg832His ENST00000275493.6:c.2495G>A 7:g.55191744G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-CV-6961-01 2193755 2062033 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51839851 COSM7340115 133230540 c.983C>A p.P328Q Substitution - Missense 38 7:55156644-55156644 + - PATHOGENIC .76649 Confirmed somatic variant 627 NS NS 61 ENSP00000415559.1:p.Pro328Gln ENST00000455089.5:c.983C>A 7:g.55156644C>A EGFR ENST00000275493.6 3633 3236 2777771 2777771 2635906 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSM7408754 178389248 c.? p.G283S Substitution - Missense + - Confirmed somatic variant 30041611 surgery-fixed NS EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV99296122 COSM7997831 132571788 c.2209C>T p.L737F Substitution - Missense 38 7:55181353-55181353 + - PATHOGENIC .94073 Confirmed somatic variant 540 NS NS 90 ENSP00000395243.3:p.Leu737Phe ENST00000454757.6:c.2209C>T 7:g.55181353C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A021-T-S20 2757382 2615995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 57 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004992 1004992 922204 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811999 2811999 2668509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed NS 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005011 1005011 922223 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-55-8096-01 2194781 2063059 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2777771 2777771 2635906 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSM7408753 178387928 c.? p.A118T Substitution - Missense + - Confirmed somatic variant 30041611 surgery-fixed NS EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV99296123 COSM7997803 132571794 c.2614G>A p.G872R Substitution - Missense 38 7:55198764-55198764 + - PATHOGENIC .97508 Confirmed somatic variant 540 NS NS 90 ENSP00000395243.3:p.Gly872Arg ENST00000454757.6:c.2614G>A 7:g.55198764G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2492703 2492703 2355318 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 132569945 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000395243.3:p.His47Tyr ENST00000454757.6:c.139C>T 7:g.55142336C>T EGFR ENST00000275493.6 3633 3236 pfg413T 2309709 2174911 stomach NS NS NS carcinoma intestinal_adenocarcinoma NS NS y COSV51771306 COSM1318972 99391332 c.1913C>T p.T638M Substitution - Missense het 38 7:55171207-55171207 + - NEUTRAL .03249 Confirmed somatic variant 24816253 surgery fresh/frozen NS 65 ENSP00000275493.2:p.Thr638Met ENST00000275493.6:c.1913C>T 7:g.55171207C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0155-01 1337821 1248206 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 132551380 c.775C>T p.H259Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 surgery fresh/frozen NS 61 ENSP00000395243.3:p.His259Tyr ENST00000454757.6:c.775C>T 7:g.55155850C>T EGFR ENST00000275493.6 3633 3236 R056-I1 2813481 2669873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 42 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766880 COSM28516 133219865 c.2269G>T p.V757F Substitution - Missense 38 7:55181413-55181413 + - PATHOGENIC .89385 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000415559.1:p.Val757Phe ENST00000455089.5:c.2269G>T 7:g.55181413G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1690853 1690853 1599120 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 132560744 c.1341C>A p.S447R Substitution - Missense 38 7:55160316-55160316 + - NEUTRAL .35843 Confirmed somatic variant 22270724 surgery - NOS recurrent 52 ENSP00000395243.3:p.Ser447Arg ENST00000454757.6:c.1341C>A 7:g.55160316C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000236-T01-IM3 2714879 2573700 ovary NS NS NS carcinoma serous_carcinoma NS NS n COSV51839606 COSM6909316 133220816 c.2399T>A p.V800E Substitution - Missense het 38 7:55191783-55191783 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Val800Glu ENST00000455089.5:c.2399T>A 7:g.55191783T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 HUB-02-B2-042 2607096 2466810 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51802097 COSM6047686 133259339 c.299C>A p.P100H Substitution - Missense 38 7:55143363-55143363 + - PATHOGENIC .9585 Confirmed somatic variant 670 organoid culture NS ENSP00000415559.1:p.Pro100His ENST00000455089.5:c.299C>A 7:g.55143363C>A EGFR ENST00000275493.6 3633 3236 HUB-02-B2-074 2607124 2466836 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51839532 COSM6040570 99381357 c.3313G>A p.V1105M Substitution - Missense 38 7:55205297-55205297 + - .69731 Confirmed somatic variant 670 organoid culture NS ENSP00000275493.2:p.Val1105Met ENST00000275493.6:c.3313G>A 7:g.55205297G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 238 2131812 2005876 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 23619168 fresh/frozen - NOS NS 50 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 MELA_34952 2760718 2619251 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV51785510 COSM6957413 99373603 c.1102G>A p.D368N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 30178487 surgery fresh/frozen metastasis 25 ENSP00000275493.2:p.Asp368Asn ENST00000275493.6:c.1102G>A 7:g.55156628G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194732 1194732 1106627 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-32-1970-01 1338089 1248474 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 128 2748100 2606803 stomach NS NS NS carcinoma NS NS NS y COSV99288147 COSM8566415 99446373 c.2831A>G p.Y944C Substitution - Missense 38 7:55198846-55198846 + - PATHOGENIC .98856 Confirmed somatic variant 683 NS primary ENSP00000275493.2:p.Tyr944Cys ENST00000275493.6:c.2831A>G 7:g.55198846A>G EGFR ENST00000275493.6 3633 3236 W016-S2 2732511 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Br213T 1313043 1223952 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 surgery - NOS primary 71 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471567 1471567 1395306 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1031893 1031893 948684 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 133222251 c.2146G>T p.D716Y Substitution - Missense het 38 7:55174818-55174818 + Yes PATHOGENIC .99554 Confirmed somatic variant 17085664 NS metastasis 72 ENSP00000415559.1:p.Asp716Tyr ENST00000455089.5:c.2146G>T 7:g.55174818G>T EGFR ENST00000275493.6 3633 3236 TCGA-27-2528-01 1338071 1248456 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 surgery fresh/frozen NS 62 ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 16668 1423695 1333723 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790297 COSM48317 132596939 c.406C>A p.P136T Substitution - Missense het 38 7:55143470-55143470 + - PATHOGENIC .9933 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Pro136Thr ENST00000454757.6:c.406C>A 7:g.55143470C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2076197 2076197 1955010 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 24396447 bronchoalveolar lavage fluid NS 78 ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 TCGA-CV-6961-01 2193755 2062033 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51839851 COSM7340115 99404654 c.1118C>A p.P373Q Substitution - Missense 38 7:55156644-55156644 + - PATHOGENIC .76649 Confirmed somatic variant 627 NS NS 61 ENSP00000275493.2:p.Pro373Gln ENST00000275493.6:c.1118C>A 7:g.55156644C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000236-T01-IM3 2714879 2573700 ovary NS NS NS carcinoma serous_carcinoma NS NS n COSV51839606 COSM6909316 132564443 c.2399T>A p.V800E Substitution - Missense het 38 7:55191783-55191783 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Val800Glu ENST00000454757.6:c.2399T>A 7:g.55191783T>A EGFR ENST00000275493.6 3633 3236 P-0007084-T02-IM5 2723457 2582278 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51779794 COSM53264 99387824 c.2174C>T p.T725M Substitution - Missense het 38 7:55174033-55174033 + - PATHOGENIC .97744 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr725Met ENST00000275493.6:c.2174C>T 7:g.55174033C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-QC-A7B5-01 2270128 2136896 soft_tissue NS NS NS sarcoma NS NS NS y COSV51772347 COSM17570 133206975 c.2087C>T p.P696L Substitution - Missense 38 7:55174759-55174759 + - PATHOGENIC .9905 Confirmed somatic variant 635 NS NS ENSP00000415559.1:p.Pro696Leu ENST00000455089.5:c.2087C>T 7:g.55174759C>T EGFR ENST00000275493.6 3633 3236 1170510 1170510 1082644 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 19117057 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 IGC-04-1052 2662293 2522417 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812078 2812078 2668549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 31534501 pleural effusion NS 72 ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460136 1460136 1384013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982860 982860 898579 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_C29 1863710 1754601 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920013 920013 837092 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51802272 COSM13425 132564786 c.2170G>A p.V724M Substitution - Missense het 38 7:55181314-55181314 + - PATHOGENIC .98024 Confirmed somatic variant 15623594 surgery fresh/frozen NS 62 ENSP00000395243.3:p.Val724Met ENST00000454757.6:c.2170G>A 7:g.55181314G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914592 914592 832041 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 82 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004999 1004999 922211 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007754-T01-IM5 2723998 2582819 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A001-T-S02 2757355 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489238 1489238 1412396 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0876 2107991 1985852 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 1468614 1468614 1392365 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM30754 178378833 c.? p.L747P Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu747Pro EGFR_ENST00000454757 ENST00000454757.6 3498 3236 B105-0-Tumor 2185749 2054046 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51776529 COSM1755314 132592444 c.1745G>A p.G582E Substitution - Missense 38 7:55165437-55165437 + - PATHOGENIC .99581 Confirmed somatic variant 581 NS NS ENSP00000395243.3:p.Gly582Glu ENST00000454757.6:c.1745G>A 7:g.55165437G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MaPT10 2491641 2354282 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004328-T02-IM5 2720735 2579556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DUMC-05 2748702 2607405 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 29802247 surgery fresh/frozen NS 51 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1165893 1165893 1078207 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16407879 cerebrospinal fluid metastasis 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PM02M 2653318 2513445 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS metastasis 75.8 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 3101B7_035_T 2390296 2253128 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51811266 COSM5041204 132575137 c.385A>G p.K129E Substitution - Missense 38 7:55143449-55143449 + - PATHOGENIC .9498 Confirmed somatic variant 25159915 NS NS ENSP00000395243.3:p.Lys129Glu ENST00000454757.6:c.385A>G 7:g.55143449A>G EGFR ENST00000275493.6 3633 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GYWU_828 2771354 2629545 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51794659 COSM6652247 132569255 c.1585C>T p.R529W Substitution - Missense 38 7:55163821-55163821 + - PATHOGENIC .97962 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000395243.3:p.Arg529Trp ENST00000454757.6:c.1585C>T 7:g.55163821C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-02-2485-01 1337809 1248194 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 133205223 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 NS NS 53 ENSP00000415559.1:p.Ala244Asp ENST00000455089.5:c.731C>A 7:g.55154129C>A EGFR ENST00000275493.6 3633 3236 2876624 2876624 2731139 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 29506987 surgery-fixed NS 48 ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0749 2107988 1985849 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003783-T01-IM5 2720274 2579095 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 2777771 2777771 2635906 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSM7408752 178389249 c.? p.S1064N Substitution - Missense + - Confirmed somatic variant 30041611 surgery-fixed NS ENSP00000275493.2:p.Ser1064Asn EGFR ENST00000275493.6 3633 3236 IGC-04-1052 2662293 2522417 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460138 1460138 1384015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790305 COSM13194 132551901 c.2405C>T p.T802I Substitution - Missense 38 7:55191789-55191789 + - PATHOGENIC .95119 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000395243.3:p.Thr802Ile ENST00000454757.6:c.2405C>T 7:g.55191789C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1790530 1790530 1693509 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51780429 COSM710350 133213787 c.2477C>T p.A826V Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .97911 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000415559.1:p.Ala826Val ENST00000455089.5:c.2477C>T 7:g.55191861C>T EGFR ENST00000275493.6 3633 3236 1113112 1113112 1026613 thymus NS NS NS thymoma NS NS NS n COSV51778659 COSM14070 99374271 c.2588G>A p.G863D Substitution - Missense het 38 7:55191837-55191837 + - PATHOGENIC .92688 Confirmed somatic variant 18448188 surgery-fixed NS 69 ENSP00000275493.2:p.Gly863Asp ENST00000275493.6:c.2588G>A 7:g.55191837G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876642 2876642 2731157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51789392 COSM3266633 133236370 c.2114C>A p.A705E Substitution - Missense 38 7:55174786-55174786 + - PATHOGENIC .9821 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000415559.1:p.Ala705Glu ENST00000455089.5:c.2114C>A 7:g.55174786C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787571 COSM6191458 133204737 c.1862T>C p.L621P Substitution - Missense 38 7:55173060-55173060 + - PATHOGENIC .99634 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000415559.1:p.Leu621Pro ENST00000455089.5:c.1862T>C 7:g.55173060T>C EGFR ENST00000275493.6 3633 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801711 COSM3923810 99432379 c.907G>A p.D303N Substitution - Missense 38 7:55155847-55155847 + - PATHOGENIC .99324 Confirmed somatic variant 540 NS NS 68 ENSP00000275493.2:p.Asp303Asn ENST00000275493.6:c.907G>A 7:g.55155847G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 R056-I1 2813481 2669873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 42 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2675062 2675062 2534337 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 29110836 surgery-fixed recurrent 36 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 T2457 2658705 2518864 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51789934 COSM6652266 99392068 c.3176C>T p.P1059L Substitution - Missense 38 7:55202530-55202530 + - PATHOGENIC .92486 Confirmed somatic variant 27149842 NS NS 75.08 ENSP00000275493.2:p.Pro1059Leu ENST00000275493.6:c.3176C>T 7:g.55202530C>T EGFR ENST00000275493.6 3633 3236 STC291 2404163 2267015 stomach NS NS NS carcinoma intestinal_adenocarcinoma NS NS y COSV51772123 COSM3266626 99378172 c.2029C>T p.R677C Substitution - Missense 38 7:55173092-55173092 + - PATHOGENIC .98355 Confirmed somatic variant 25042771 surgery fresh/frozen primary 75 ENSP00000275493.2:p.Arg677Cys ENST00000275493.6:c.2029C>T 7:g.55173092C>T EGFR ENST00000275493.6 3633 3236 2842026 2842026 2697575 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 99387971 c.1474A>C p.S492R Substitution - Missense 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000275493.2:p.Ser492Arg ENST00000275493.6:c.1474A>C 7:g.55160314A>C EGFR ENST00000275493.6 3633 3236 XHDG25 2306032 2171303 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV51811244 COSM4767521 99378712 c.607G>A p.G203R Substitution - Missense 38 7:55151341-55151341 + - PATHOGENIC .99471 Confirmed somatic variant 24997986 NS NS ENSP00000275493.2:p.Gly203Arg ENST00000275493.6:c.607G>A 7:g.55151341G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000913-T03-IM5 2719384 2578205 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 7T 2473854 2336624 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51794834 COSM5575633 133214600 c.2738G>A p.R913H Substitution - Missense 38 7:55200340-55200340 + - PATHOGENIC .99504 Confirmed somatic variant 26489445 fixed - NOS NS ENSP00000415559.1:p.Arg913His ENST00000455089.5:c.2738G>A 7:g.55200340G>A EGFR ENST00000275493.6 3633 3236 P-0003783-T01-IM5 2720274 2579095 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-0749 2107988 1985849 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008179-T02-IM5 2830115 2685930 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 133209185 c.1639G>A p.V547I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000415559.1:p.Val547Ile ENST00000455089.5:c.1639G>A 7:g.55165331G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD7043a 1504254 1427132 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia NS n COSV51852469 COSM4384119 133208076 c.1282A>G p.N428D Substitution - Missense 38 7:55160257-55160257 + - NEUTRAL .3314 Confirmed somatic variant 24030381 NS NS ENSP00000415559.1:p.Asn428Asp ENST00000455089.5:c.1282A>G 7:g.55160257A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005076-T01-IM5 2721479 2580300 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51836384 COSM6940904 132575800 c.2071G>A p.E691K Substitution - Missense het 38 7:55174743-55174743 + - PATHOGENIC .99879 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Glu691Lys ENST00000454757.6:c.2071G>A 7:g.55174743G>A EGFR ENST00000275493.6 3633 3236 CRC334 2730827 2589596 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51767379 COSM85894 99384993 c.2527G>A p.V843I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 26416732 xenograft metastasis 65 ENSP00000275493.2:p.Val843Ile ENST00000275493.6:c.2527G>A 7:g.55191776G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51841863 COSM6913649 132550692 c.3280C>T p.L1094F Substitution - Missense het 38 7:55205399-55205399 + - PATHOGENIC .96614 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu1094Phe ENST00000454757.6:c.3280C>T 7:g.55205399C>T EGFR ENST00000275493.6 3633 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV99296122 COSM7997831 99403867 c.2344C>T p.L782F Substitution - Missense 38 7:55181353-55181353 + - PATHOGENIC .94073 Confirmed somatic variant 540 NS NS 90 ENSP00000275493.2:p.Leu782Phe ENST00000275493.6:c.2344C>T 7:g.55181353C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787547 COSM6191455 133204726 c.991T>C p.F331L Substitution - Missense 38 7:55156652-55156652 + - PATHOGENIC .98052 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000415559.1:p.Phe331Leu ENST00000455089.5:c.991T>C 7:g.55156652T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-28-1752-01 2178270 2046568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 329 NS NS 42 ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 PD4604a 1356528 1266569 breast NS NS NS carcinoma lobular_carcinoma NS NS y COSV51822879 COSM4680399 99382634 c.2039G>A p.R680Q Substitution - Missense 38 7:55173102-55173102 + - PATHOGENIC .99814 Confirmed somatic variant 652 NS primary ENSP00000275493.2:p.Arg680Gln ENST00000275493.6:c.2039G>A 7:g.55173102G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876608 2876608 2731123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832145 COSM6493936 132574809 c.2254T>G p.C752G Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95801 Confirmed somatic variant 29506987 circulating tumour NS ENSP00000395243.3:p.Cys752Gly ENST00000454757.6:c.2254T>G 7:g.55181398T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-KK-A59Y-01 2340238 2205221 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51814881 COSM3929116 132567904 c.799G>T p.G267W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 435 NS primary 56 ENSP00000395243.3:p.Gly267Trp ENST00000454757.6:c.799G>T 7:g.55155874G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-14-0866-01 2178121 2046419 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99295486 COSM7482458 133228338 c.1004C>T p.S335F Substitution - Missense 38 7:55156764-55156764 + - NEUTRAL .25937 Confirmed somatic variant 329 NS NS 55 ENSP00000415559.1:p.Ser335Phe ENST00000455089.5:c.1004C>T 7:g.55156764C>T EGFR ENST00000275493.6 3633 3236 P-0002649-T01-IM3 2718895 2577716 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51794834 COSM5575633 99386191 c.2873G>A p.R958H Substitution - Missense het 38 7:55200340-55200340 + - PATHOGENIC .99504 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg958His ENST00000275493.6:c.2873G>A 7:g.55200340G>A EGFR ENST00000275493.6 3633 3236 2876642 2876642 2731157 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51789392 COSM3266633 99409252 c.2249C>A p.A750E Substitution - Missense 38 7:55174786-55174786 + - PATHOGENIC .9821 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000275493.2:p.Ala750Glu ENST00000275493.6:c.2249C>A 7:g.55174786C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DK-AA75-01 2385754 2248586 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51771467 COSM7104388 132562920 c.942C>A p.F314L Substitution - Missense 38 7:55156603-55156603 + - PATHOGENIC .96682 Confirmed somatic variant 413 NS primary 82 ENSP00000395243.3:p.Phe314Leu ENST00000454757.6:c.942C>A 7:g.55156603C>A EGFR ENST00000275493.6 3633 3236 P-0005943-T01-IM5 2829924 2685739 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51829196 COSM6947106 99389909 c.3203G>A p.R1068Q Substitution - Missense 38 7:55202557-55202557 + - PATHOGENIC .97786 Confirmed somatic variant 30205045 surgery-fixed metastasis 41 ENSP00000275493.2:p.Arg1068Gln ENST00000275493.6:c.3203G>A 7:g.55202557G>A EGFR ENST00000275493.6 3633 3236 2591411 2591411 2452371 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468630 1468630 1392381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010610-T01-IM5 2726309 2585130 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51839766 COSM6975560 132554442 c.1729C>G p.P577A Substitution - Missense het 38 7:55165421-55165421 + - NEUTRAL .24318 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Pro577Ala ENST00000454757.6:c.1729C>G 7:g.55165421C>G EGFR ENST00000275493.6 3633 3236 2862445 2862445 2717612 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 31694833 surgery-fixed primary 67 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 pfg413T 2309709 2174911 stomach NS NS NS carcinoma intestinal_adenocarcinoma NS NS y COSV51771306 COSM1318972 133218950 c.1778C>T p.T593M Substitution - Missense het 38 7:55171207-55171207 + - NEUTRAL .03249 Confirmed somatic variant 24816253 surgery fresh/frozen NS 65 ENSP00000415559.1:p.Thr593Met ENST00000455089.5:c.1778C>T 7:g.55171207C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2014_Lung_sq_15_T 2744886 2603589 lung NS NS NS carcinoma NS NS NS y COSV51805367 COSM3950642 132575213 c.904G>A p.D302N Substitution - Missense 38 7:55156565-55156565 + - PATHOGENIC .82248 Confirmed somatic variant 583 NS primary 72 ENSP00000395243.3:p.Asp302Asn ENST00000454757.6:c.904G>A 7:g.55156565G>A EGFR ENST00000275493.6 3633 3236 P-0004328-T02-IM5 2720735 2579556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 T_CCA_SG_13 2688086 2547068 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV51803429 COSM7002279 99384811 c.1280G>A p.R427H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Confirmed somatic variant 653 NS primary 60 ENSP00000275493.2:p.Arg427His ENST00000275493.6:c.1280G>A 7:g.55157735G>A EGFR ENST00000275493.6 3633 3236 T521 2658729 2518888 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51769243 COSM6652288 99431355 c.2302A>G p.S768G Substitution - Missense 38 7:55181311-55181311 + - PATHOGENIC .97311 Confirmed somatic variant 27149842 NS NS 62.83 ENSP00000275493.2:p.Ser768Gly ENST00000275493.6:c.2302A>G 7:g.55181311A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003512-T01-IM5 2719993 2578814 soft_tissue fibrous_tissue_and_uncertain_origin NS NS synovial_sarcoma NS NS NS n COSV51846648 COSM244213 132558577 c.2246C>A p.P749H Substitution - Missense het 38 7:55181390-55181390 + - PATHOGENIC .97291 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Pro749His ENST00000454757.6:c.2246C>A 7:g.55181390C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812078 2812078 2668549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51776947 COSM6910370 133220707 c.2362T>A p.L788M Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .36784 Confirmed somatic variant 31534501 pleural effusion NS 72 ENSP00000415559.1:p.Leu788Met ENST00000455089.5:c.2362T>A 7:g.55191746T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CTS21 2393074 2255905 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005337-T01-IM5 2721741 2580562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A017-T-S11 2757376 2615994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 56 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008577-T01-IM5 2724677 2583498 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1179549 1179549 1091511 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A001-T-S01 2757354 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489261 1489261 1412419 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 55 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0004650-T01-IM5 2721049 2579870 NS NS NS NS malignant_melanoma NS NS NS n COSV51781521 COSM6912042 99435886 c.3055C>T p.P1019S Substitution - Missense het 38 7:55201296-55201296 + - PATHOGENIC .99234 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Pro1019Ser ENST00000275493.6:c.3055C>T 7:g.55201296C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003512-T01-IM5 2719993 2578814 soft_tissue fibrous_tissue_and_uncertain_origin NS NS synovial_sarcoma NS NS NS n COSV51846648 COSM244213 133214685 c.2246C>A p.P749H Substitution - Missense het 38 7:55181390-55181390 + - PATHOGENIC .97291 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Pro749His ENST00000455089.5:c.2246C>A 7:g.55181390C>A EGFR ENST00000275493.6 3633 3236 TCGA-06-0876 2107991 1985852 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 TCGA-FG-A4MU-01 2194395 2062673 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 58 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787571 COSM6191458 132549771 c.1862T>C p.L621P Substitution - Missense 38 7:55173060-55173060 + - PATHOGENIC .99634 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000395243.3:p.Leu621Pro ENST00000454757.6:c.1862T>C 7:g.55173060T>C EGFR ENST00000275493.6 3633 3236 M702PT 2671818 2531377 pleura NS NS NS mesothelioma epithelial NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26928227 surgery fresh/frozen primary 30 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 P-0000236-T01-IM3 2714879 2573700 ovary NS NS NS carcinoma serous_carcinoma NS NS n COSV51839606 COSM6909316 99393741 c.2534T>A p.V845E Substitution - Missense het 38 7:55191783-55191783 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Val845Glu ENST00000275493.6:c.2534T>A 7:g.55191783T>A EGFR ENST00000275493.6 3633 3236 OSCC-GB_00130111 2121052 1995288 upper_aerodigestive_tract mouth NS NS carcinoma NS NS NS y COSV51815394 COSM3715755 99383912 c.738C>A p.S246R Substitution - Missense 38 7:55152655-55152655 + - NEUTRAL .15461 Confirmed somatic variant 539 NS NS ENSP00000275493.2:p.Ser246Arg ENST00000275493.6:c.738C>A 7:g.55152655C>A EGFR ENST00000275493.6 3633 3236 YUROG 2439363 2302204 skin NS NS NS malignant_melanoma NS NS NS y COSV51803218 COSM5407729 99453293 c.2407C>T p.R803W Substitution - Missense het 38 7:55181416-55181416 + - PATHOGENIC .85795 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 58 ENSP00000275493.2:p.Arg803Trp ENST00000275493.6:c.2407C>T 7:g.55181416C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982787 982787 898506 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766331 COSM12366 132582479 c.2437C>A p.L813M Substitution - Missense 38 7:55191821-55191821 + - PATHOGENIC .93782 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Met ENST00000454757.6:c.2437C>A 7:g.55191821C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-32-1970-01 1338089 1248474 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194732 1194732 1106627 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 14_S4 2902121 2756359 autonomic_ganglia NS NS NS neuroblastoma NS NS NS n COSV105863896 COSM9976114 132566017 c.683C>G p.T228S Substitution - Missense 38 7:55154081-55154081 + - PATHOGENIC .94747 Confirmed somatic variant 33381456 circulating tumour primary 7 ENSP00000395243.3:p.Thr228Ser ENST00000454757.6:c.683C>G 7:g.55154081C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211135 1211135 1123003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 53 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003213-T01-IM5 2719708 2578529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1079263 1079263 994483 soft_tissue fibrous_tissue_and_uncertain_origin kidney NS malignant_melanoma_of_soft_parts-clear_cell_sarcoma NS NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 17646270 surgery - NOS NS 1.8 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 238 2131812 2005876 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 23619168 fresh/frozen - NOS NS 50 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876596 2876596 2731111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 133219858 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 64 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2255G>C 7:g.55181399G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2492703 2492703 2355318 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 99401924 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000275493.2:p.His47Tyr ENST00000275493.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008346-T01-IM5 2724474 2583295 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51838649 COSM6962468 132582557 c.412A>G p.R138G Substitution - Missense het 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg138Gly ENST00000454757.6:c.412A>G 7:g.55143476A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T578 2296255 2161858 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51788796 COSM4680390 132569555 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 25344691 NS NS 61.08 ENSP00000395243.3:p.Arg98Gln ENST00000454757.6:c.293G>A 7:g.55143357G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCG-Testes_DFCI_3-Tumor-SM-4PDD6 2806592 2663310 testis NS NS NS germ_cell_tumour mixed NS NS y COSV99289610 COSM9116988 133216634 c.2944C>T p.P982S Substitution - Missense het 38 7:55201320-55201320 + - PATHOGENIC .99685 Confirmed somatic variant 27905446 fixed - NOS metastasis ENSP00000415559.1:p.Pro982Ser ENST00000455089.5:c.2944C>T 7:g.55201320C>T EGFR ENST00000275493.6 3633 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV99296123 COSM7997803 99403872 c.2749G>A p.G917R Substitution - Missense 38 7:55198764-55198764 + - PATHOGENIC .97508 Confirmed somatic variant 540 NS NS 90 ENSP00000275493.2:p.Gly917Arg ENST00000275493.6:c.2749G>A 7:g.55198764G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011333-T01-IM5 2726929 2585750 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51864136 COSM6980296 132554466 c.2890G>T p.D964Y Substitution - Missense het 38 7:55201266-55201266 + - PATHOGENIC .98461 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Asp964Tyr ENST00000454757.6:c.2890G>T 7:g.55201266G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-25-2404-01 1474989 1398688 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV99292585 COSM7509017 132560966 c.1246G>A p.V416M Substitution - Missense 38 7:55160221-55160221 + - PATHOGENIC .98193 Confirmed somatic variant 331 NS primary 38 ENSP00000395243.3:p.Val416Met ENST00000454757.6:c.1246G>A 7:g.55160221G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-25-2404-01 1474989 1398688 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV99292585 COSM7509017 132560966 c.1246G>A p.V416M Substitution - Missense 38 7:55160221-55160221 + - PATHOGENIC .98193 Confirmed somatic variant 21720365 331 NS primary 38 ENSP00000395243.3:p.Val416Met ENST00000454757.6:c.1246G>A 7:g.55160221G>A EGFR ENST00000275493.6 3633 3236 2876034 2876034 2730549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 99388191 c.2389T>A p.C797S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour recurrent 44 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2389T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MBC_174 2662675 2522799 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS y COSV51792227 COSM6582372 132554391 c.2524T>A p.L842I Substitution - Missense 38 7:55192799-55192799 + - PATHOGENIC .84827 Confirmed somatic variant 28027327 fresh/frozen - NOS NS ENSP00000395243.3:p.Leu842Ile ENST00000454757.6:c.2524T>A 7:g.55192799T>A EGFR ENST00000275493.6 3633 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 99392455 c.2375T>A p.L792H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000275493.2:p.Leu792His ENST00000275493.6:c.2375T>A 7:g.55181384T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KD826 1005019 922231 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 W016-S2 2732511 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T_CCA_SG_13 2688086 2547068 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV51803429 COSM7002279 133213353 c.1145G>A p.R382H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Confirmed somatic variant 653 NS primary 60 ENSP00000415559.1:p.Arg382His ENST00000455089.5:c.1145G>A 7:g.55157735G>A EGFR ENST00000275493.6 3633 3236 2690101 2690101 2549076 upper_aerodigestive_tract sinonasal_and_nasal_cavity NS NS carcinoma undifferentiated_carcinoma NS NS n COSM6904472 178378654 c.? p.M318I Substitution - Missense + - Confirmed somatic variant 28493366 surgery-fixed primary 48 ENSP00000275493.2:p.Met318Ile EGFR ENST00000275493.6 3633 3236 TCGA-06-6700-01 2120280 1994516 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772666 COSM3412205 99378959 c.2947G>A p.G983R Substitution - Missense 38 7:55201188-55201188 + - PATHOGENIC .98883 Confirmed somatic variant 329 NS NS 76 ENSP00000275493.2:p.Gly983Arg ENST00000275493.6:c.2947G>A 7:g.55201188G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1468098 1468098 1391944 peritoneum NS NS NS mesothelioma NS NS NS n COSV51801471 COSM53105 133208181 c.2357G>A p.R786H Substitution - Missense het 38 7:55191741-55191741 + - PATHOGENIC .96289 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000415559.1:p.Arg786His ENST00000455089.5:c.2357G>A 7:g.55191741G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51770694 COSM20891 133218993 c.2251G>A p.G751S Substitution - Missense 38 7:55181395-55181395 + Yes PATHOGENIC .98244 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000415559.1:p.Gly751Ser ENST00000455089.5:c.2251G>A 7:g.55181395G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CGCRC167 2434467 2297344 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV105863924 COSM10049276 132567478 c.905A>T p.D302V Substitution - Missense 38 7:55156566-55156566 + - PATHOGENIC .89104 Confirmed somatic variant 26416732 surgery - NOS primary 81 ENSP00000395243.3:p.Asp302Val ENST00000454757.6:c.905A>T 7:g.55156566A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007504-T01-IM5 2723789 2582610 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 2812094 2812094 2668557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 31534501 pleural effusion NS 63 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000435-T01-IM3 2786865 2644288 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51776947 COSM6910370 132564250 c.2362T>A p.L788M Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .36784 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000395243.3:p.Leu788Met ENST00000454757.6:c.2362T>A 7:g.55191746T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 B105-1 2097255 1975319 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV51787208 COSM327142 132549881 c.3217G>A p.A1073T Substitution - Missense 38 7:55205336-55205336 + - NEUTRAL .10522 Confirmed somatic variant 24121792 fresh/frozen - NOS NS ENSP00000395243.3:p.Ala1073Thr ENST00000454757.6:c.3217G>A 7:g.55205336G>A EGFR ENST00000275493.6 3633 3236 TCGA-BB-A5HY-01 2385721 2248553 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99289265 COSM8389919 99447293 c.1255G>C p.A419P Substitution - Missense 38 7:55157710-55157710 + - PATHOGENIC .9183 Confirmed somatic variant 627 NS primary 64 ENSP00000275493.2:p.Ala419Pro ENST00000275493.6:c.1255G>C 7:g.55157710G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876596 2876596 2731111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 64 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CCRF-CEM 1998437 1883509 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51787208 COSM327142 132549881 c.3217G>A p.A1073T Substitution - Missense het 38 7:55205336-55205336 + - NEUTRAL .10522 Confirmed somatic variant 23856246 cell-line primary ENSP00000395243.3:p.Ala1073Thr ENST00000454757.6:c.3217G>A 7:g.55205336G>A EGFR ENST00000275493.6 3633 3236 TCGA-A6-3809-01 1901050 1789730 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51844677 COSM6984453 99399892 c.2999C>T p.A1000V Substitution - Missense 38 7:55201240-55201240 + - PATHOGENIC .95761 Confirmed somatic variant 376 fresh/frozen - NOS primary 71 ENSP00000275493.2:p.Ala1000Val ENST00000275493.6:c.2999C>T 7:g.55201240C>T EGFR ENST00000275493.6 3633 3236 P-0008145-T02-IM5 2724310 2583131 breast NS NS NS carcinoma NS NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1040349 1040349 956926 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_II NS NS n COSV51790148 COSM22555 133209794 c.1895G>A p.R632H Substitution - Missense 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000415559.1:p.Arg632His ENST00000455089.5:c.1895G>A 7:g.55173093G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SK01600_P 1951898 1838690 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51835132 COSM1600351 132588213 c.842G>C p.C281S Substitution - Missense het 38 7:55155917-55155917 + - PATHOGENIC .99486 Confirmed somatic variant 23441165 surgery - NOS primary 57 ENSP00000395243.3:p.Cys281Ser ENST00000454757.6:c.842G>C 7:g.55155917G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 J36 2815364 2671744 central_nervous_system brain NS NS glioma astrocytoma_Grade_II fibrillary NS y COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 29263181 surgery fresh/frozen NS 48 ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008145-T02-IM5 2724310 2583131 breast NS NS NS carcinoma NS NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914567 914567 832016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 15788655 surgery fresh/frozen primary 83 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876596 2876596 2731111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 132563575 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 64 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2255G>C 7:g.55181399G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011543-T01-IM5 2727115 2585936 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51806727 COSM6978402 132559850 c.2183_2185delinsTCA p.H728_V729delinsLM Substitution - Missense het 38 7:55181327-55181329 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.His728_Val729delinsLeuMet ENST00000454757.6:c.2183_2185delinsTCA 7:g.55181327_55181329delinsTCA EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876034 2876034 2730549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 44 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 99392475 c.2390G>C p.C797S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2390G>C 7:g.55181399G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2076197 2076197 1955010 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 24396447 bronchoalveolar lavage fluid NS 78 ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 1468648 1468648 1392399 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1312391 1312391 1223300 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 71 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468653 1468653 1392404 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1139403 1139403 1051967 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 18317075 surgery - NOS metastasis 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1312387 1312387 1223296 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 945811 945811 862337 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 16144918 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KD514 1005018 922230 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 914567 914567 832016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 15788655 surgery fresh/frozen primary 83 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 P-0008145-T02-IM5 2724310 2583131 breast NS NS NS carcinoma NS NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1170507 1170507 1082641 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 19117057 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468625 1468625 1392376 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0004066-T01-IM5 2720468 2579289 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0010337-T01-IM5 2726104 2584925 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A021-T-S02 2757379 2615995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 57 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982877 982877 898596 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A114-T-S23 2757426 2616005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KD514 1005018 922230 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000280-T01-IM3 2714952 2573773 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489248 1489248 1412406 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001258 1001258 918481 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009864-T01-IM5 2725703 2584524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458701 1458701 1382676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920023 920023 837102 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 82 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004342-T01-IM5 2720749 2579570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876610 2876610 2731125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 112503 1520680 1443055 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20668451 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1063622 1063622 979667 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 53 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152773 2152773 2021783 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1044280 1044280 960621 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 41 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-F1-6177-01 2198156 2066434 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51817351 COSM3881830 133223235 c.2957G>A p.R986Q Substitution - Missense 38 7:55201333-55201333 + - PATHOGENIC .98371 Confirmed somatic variant 541 NS NS 90 ENSP00000415559.1:p.Arg986Gln ENST00000455089.5:c.2957G>A 7:g.55201333G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1790530 1790530 1693509 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51780429 COSM710350 132557726 c.2477C>T p.A826V Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .97911 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000395243.3:p.Ala826Val ENST00000454757.6:c.2477C>T 7:g.55191861C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GYWU_534 2771325 2629517 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV99291764 COSM7410245 132560189 c.2809C>A p.Q937K Substitution - Missense 38 7:55200411-55200411 + - PATHOGENIC .99148 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000395243.3:p.Gln937Lys ENST00000454757.6:c.2809C>A 7:g.55200411C>A EGFR ENST00000275493.6 3633 3236 982787 982787 898506 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV51769815 COSM249886 99403766 c.2096C>T p.P699L Substitution - Missense 38 7:55173955-55173955 + - PATHOGENIC .97389 Confirmed somatic variant 540 NS NS 90 ENSP00000275493.2:p.Pro699Leu ENST00000275493.6:c.2096C>T 7:g.55173955C>T EGFR ENST00000275493.6 3633 3236 TCG-Testes_DFCI_3-Tumor-SM-4PDD6 2806592 2663310 testis NS NS NS germ_cell_tumour mixed NS NS y COSV99289610 COSM9116988 99388693 c.3079C>T p.P1027S Substitution - Missense het 38 7:55201320-55201320 + - PATHOGENIC .99685 Confirmed somatic variant 27905446 fixed - NOS metastasis ENSP00000275493.2:p.Pro1027Ser ENST00000275493.6:c.3079C>T 7:g.55201320C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BR-6452-01 2197940 2066218 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51804028 COSM3881820 132558993 c.1372G>T p.G458C Substitution - Missense 38 7:55161507-55161507 + - NEUTRAL .38516 Confirmed somatic variant 541 NS NS 78 ENSP00000395243.3:p.Gly458Cys ENST00000454757.6:c.1372G>T 7:g.55161507G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812094 2812094 2668557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 31534501 pleural effusion NS 63 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1468096 1468096 1391942 peritoneum NS NS NS mesothelioma NS NS NS n COSV51771943 COSM22953 132569426 c.2266T>C p.Y756H Substitution - Missense het 38 7:55181410-55181410 + - PATHOGENIC .96426 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000395243.3:p.Tyr756His ENST00000454757.6:c.2266T>C 7:g.55181410T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 R056-I1 2813481 2669873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 42 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2749050 2749050 2607753 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS n COSV51827262 COSM53226 133217545 c.1964A>G p.N655S Substitution - Missense 38 7:55173958-55173958 + - PATHOGENIC .97158 Confirmed somatic variant 29360550 surgery-fixed NS 69 ENSP00000415559.1:p.Asn655Ser ENST00000455089.5:c.1964A>G 7:g.55173958A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S_TBL200_R5 2757769 2616343 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29106415 autopsy - NOS metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812097 2812097 2668558 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 circulating tumour NS 78 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152774 2152774 2021784 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982885 982885 898604 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 16786 1423727 1333755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EXTERN_MELA_20140924_131 2839485 2695251 skin scalp NS NS malignant_melanoma NS NS NS y COSV104576577 COSM9396332 132562107 c.1256C>T p.S419L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000395243.3:p.Ser419Leu ENST00000454757.6:c.1256C>T 7:g.55160231C>T EGFR ENST00000275493.6 3633 3236 279 2748251 2606954 stomach NS NS NS carcinoma NS NS NS y COSV99290218 COSM8504937 99447633 c.3590A>G p.Y1197C Substitution - Missense 38 7:55205574-55205574 + - PATHOGENIC .97561 Confirmed somatic variant 683 NS primary ENSP00000275493.2:p.Tyr1197Cys ENST00000275493.6:c.3590A>G 7:g.55205574A>G EGFR ENST00000275493.6 3633 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51781835 COSM174732 99379122 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Glu114Lys ENST00000275493.6:c.340G>A 7:g.55143404G>A EGFR ENST00000275493.6 3633 3236 TCGA-AD-6964-01 1651148 1565935 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51806191 COSM1451618 99425802 c.3094A>T p.T1032S Substitution - Missense 38 7:55201335-55201335 + - PATHOGENIC .99325 Confirmed somatic variant 376 NS NS 58 ENSP00000275493.2:p.Thr1032Ser ENST00000275493.6:c.3094A>T 7:g.55201335A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GYWU_828 2771354 2629545 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51794659 COSM6652247 133226550 c.1585C>T p.R529W Substitution - Missense 38 7:55163821-55163821 + - PATHOGENIC .97962 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000415559.1:p.Arg529Trp ENST00000455089.5:c.1585C>T 7:g.55163821C>T EGFR ENST00000275493.6 3633 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51860329 COSM13190 99392465 c.2375T>C p.L792P Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .95089 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000275493.2:p.Leu792Pro ENST00000275493.6:c.2375T>C 7:g.55181384T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-KK-A59Y-01 2340238 2205221 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51814881 COSM3929116 133224708 c.799G>T p.G267W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 435 NS primary 56 ENSP00000415559.1:p.Gly267Trp ENST00000455089.5:c.799G>T 7:g.55155874G>T EGFR ENST00000275493.6 3633 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A102-T-S37 2757415 2616002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458700 1458700 1382675 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876062 2876062 2730577 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 494 898391 816003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460138 1460138 1384015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206766 1206766 1118644 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001514-T01-IM3 2717445 2576266 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005034-T01-IM5 2721439 2580260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982871 982871 898590 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0004379-T01-IM5 2720790 2579611 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51857819 COSM6935325 99392104 c.1397A>C p.N466T Substitution - Missense het 38 7:55160237-55160237 + - PATHOGENIC .99346 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Asn466Thr ENST00000275493.6:c.1397A>C 7:g.55160237A>C EGFR ENST00000275493.6 3633 3236 TCGA-28-1752-01 2178270 2046568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 329 NS NS 42 ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 TCGA-43-A56U-01 2195058 2063336 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99290842 COSM8713904 99444885 c.575C>G p.P192R Substitution - Missense 38 7:55151309-55151309 + - PATHOGENIC .9684 Confirmed somatic variant 418 NS NS 76 ENSP00000275493.2:p.Pro192Arg ENST00000275493.6:c.575C>G 7:g.55151309C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005337-T01-IM5 2721741 2580562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007084-T02-IM5 2723457 2582278 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51779794 COSM53264 133215961 c.2039C>T p.T680M Substitution - Missense het 38 7:55174033-55174033 + - PATHOGENIC .97744 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr680Met ENST00000455089.5:c.2039C>T 7:g.55174033C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0750 2107989 1985850 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51807036 COSM2151966 133217490 c.1652C>G p.P551R Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99615 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Pro551Arg ENST00000455089.5:c.1652C>G 7:g.55165344C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1113112 1113112 1026613 thymus NS NS NS thymoma NS NS NS n COSV51778659 COSM14070 133202857 c.2453G>A p.G818D Substitution - Missense het 38 7:55191837-55191837 + - PATHOGENIC .92688 Confirmed somatic variant 18448188 surgery-fixed NS 69 ENSP00000415559.1:p.Gly818Asp ENST00000455089.5:c.2453G>A 7:g.55191837G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009852-T01-IM5 2725690 2584511 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51768139 COSM21685 132550339 c.731C>A p.A244D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Asp ENST00000454757.6:c.731C>A 7:g.55154129C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DA-A3F3-06 2121581 1995817 skin NS NS NS malignant_melanoma NS NS NS y COSV51816429 COSM1698693 132561822 c.1675A>G p.N559D Substitution - Missense 38 7:55165367-55165367 + - NEUTRAL .4812 Confirmed somatic variant 540 NS NS 52 ENSP00000395243.3:p.Asn559Asp ENST00000454757.6:c.1675A>G 7:g.55165367A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 133219841 c.2240T>A p.L747H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000415559.1:p.Leu747His ENST00000455089.5:c.2240T>A 7:g.55181384T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EOSRC-IN-2785 2902114 2756352 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV105864249 COSM9977627 132588034 c.2276A>T p.E759V Substitution - Missense 38 7:55181420-55181420 + - PATHOGENIC .97936 Confirmed somatic variant 33262464 surgery - NOS NS 55 ENSP00000395243.3:p.Glu759Val ENST00000454757.6:c.2276A>T 7:g.55181420A>T EGFR ENST00000275493.6 3633 3236 5-WS012-T2 2869948 2724945 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110279 COSM9809368 99456793 c.299C>T p.P100L Substitution - Missense 38 7:55143363-55143363 + - PATHOGENIC .96024 Confirmed somatic variant 26950094 surgery - NOS NS 82 ENSP00000275493.2:p.Pro100Leu ENST00000275493.6:c.299C>T 7:g.55143363C>T EGFR ENST00000275493.6 3633 3236 2876609 2876609 2731124 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876034 2876034 2730549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 44 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BP-4341-01 2120462 1994698 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51785438 COSM3366978 132583357 c.2360G>A p.R787H Substitution - Missense 38 7:55191744-55191744 + - PATHOGENIC .9403 Confirmed somatic variant 416 NS NS 67 ENSP00000395243.3:p.Arg787His ENST00000454757.6:c.2360G>A 7:g.55191744G>A EGFR ENST00000275493.6 3633 3236 082 1630826 1547696 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51769737 COSM145359 99419486 c.3502G>A p.D1168N Substitution - Missense 38 7:55205486-55205486 + - PATHOGENIC .97139 Confirmed somatic variant 22158541 blood-bone marrow NS ENSP00000275493.2:p.Asp1168Asn ENST00000275493.6:c.3502G>A 7:g.55205486G>A EGFR ENST00000275493.6 3633 3236 TCGA-24-2289-01 1475125 1398824 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51801941 COSM116797 99402122 c.2147A>G p.K716R Substitution - Missense het 38 7:55174006-55174006 + - PATHOGENIC .96091 Confirmed somatic variant 21720365 331 NS primary 68 ENSP00000275493.2:p.Lys716Arg ENST00000275493.6:c.2147A>G 7:g.55174006A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0876 2107991 1985852 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 P-0009852-T01-IM5 2725690 2584511 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51768139 COSM21685 99377226 c.866C>A p.A289D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Asp ENST00000275493.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 B72-S1 2732506 2591266 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 132560457 c.953C>T p.T318I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 29244145 surgery fresh/frozen primary 76.6 ENSP00000395243.3:p.Thr318Ile ENST00000454757.6:c.953C>T 7:g.55156614C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006863-T01-IM5 2723243 2582064 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51788393 COSM13979 132563273 c.2035G>A p.G679S Substitution - Missense het 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly679Ser ENST00000454757.6:c.2035G>A 7:g.55174029G>A EGFR ENST00000275493.6 3633 3236 1109725 1109725 1023635 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 53 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0008744-T01-IM5 2724793 2583614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471547 1471547 1395286 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152794 2152794 2021804 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1790523 1790523 1693502 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0003317-T02-IM5 2719811 2578632 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1031893 1031893 948684 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17085664 NS metastasis 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206745 1206745 1118623 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2901988 2901988 2756229 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Leu861Arg EGFR ENST00000275493.6 3633 3236 TCGA-19-5956-01 2178192 2046490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99292946 COSM7469776 99432554 c.461C>A p.P154H Substitution - Missense 38 7:55146642-55146642 + - PATHOGENIC .80234 Confirmed somatic variant 329 NS NS 53 ENSP00000275493.2:p.Pro154His ENST00000275493.6:c.461C>A 7:g.55146642C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004400-T01-IM5 2720811 2579632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 2812078 2812078 2668549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 31534501 pleural effusion NS 72 ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 EXTERN_MELA_20140524_020 2839454 2695220 skin trunk NS NS malignant_melanoma NS NS NS y COSV104577006 COSM9447599 99406135 c.3131A>G p.N1044S Substitution - Missense 38 7:55201751-55201751 + - NEUTRAL .35447 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000275493.2:p.Asn1044Ser ENST00000275493.6:c.3131A>G 7:g.55201751A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KD826 1005019 922231 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-26-5139 2108061 1985922 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51840469 COSM2157152 133257211 c.1748G>T p.C583F Substitution - Missense 38 7:55171177-55171177 + - PATHOGENIC .98352 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Cys583Phe ENST00000455089.5:c.1748G>T 7:g.55171177G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 W016-S2 2732511 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-D3-A8GC-06 2262878 2129862 skin NS NS NS malignant_melanoma NS NS NS y COSV51822525 COSM6922832 132581780 c.1205C>T p.S402F Substitution - Missense 38 7:55160180-55160180 + - .61329 Confirmed somatic variant 540 NS NS 48 ENSP00000395243.3:p.Ser402Phe ENST00000454757.6:c.1205C>T 7:g.55160180C>T EGFR ENST00000275493.6 3633 3236 1471567 1471567 1395306 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 CGCRC167 2434467 2297344 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV105863924 COSM10049276 99398907 c.1040A>T p.D347V Substitution - Missense 38 7:55156566-55156566 + - PATHOGENIC .89104 Confirmed somatic variant 26416732 surgery - NOS primary 81 ENSP00000275493.2:p.Asp347Val ENST00000275493.6:c.1040A>T 7:g.55156566A>T EGFR ENST00000275493.6 3633 3236 P-0000348-T01-IM3 2715088 2573909 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51782925 COSM24267 99377339 c.2239_2240delinsCC p.L747P Substitution - Missense het 38 7:55174776-55174777 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu747Pro ENST00000275493.6:c.2239_2240delinsCC 7:g.55174776_55174777delinsCC EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787547 COSM6191455 132549762 c.991T>C p.F331L Substitution - Missense 38 7:55156652-55156652 + - PATHOGENIC .98052 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000395243.3:p.Phe331Leu ENST00000454757.6:c.991T>C 7:g.55156652T>C EGFR ENST00000275493.6 3633 3236 S_TBL200_R5 2757769 2616343 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29106415 autopsy - NOS metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2812097 2812097 2668558 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 circulating tumour NS 78 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Br215T 1313044 1223953 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51785554 COSM21688 132548847 c.836G>T p.R279L Substitution - Missense het 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 18772396 surgery - NOS primary 50 ENSP00000395243.3:p.Arg279Leu ENST00000454757.6:c.836G>T 7:g.55155911G>T EGFR ENST00000275493.6 3633 3236 TCGA-32-1982-01 1338091 1248476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 76 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 XHDG25 2306032 2171303 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV51811244 COSM4767521 133206798 c.472G>A p.G158R Substitution - Missense 38 7:55151341-55151341 + - PATHOGENIC .99471 Confirmed somatic variant 24997986 NS NS ENSP00000415559.1:p.Gly158Arg ENST00000455089.5:c.472G>A 7:g.55151341G>A EGFR ENST00000275493.6 3633 3236 PD6511a 1491955 1415113 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_unilineage_dysplasia refractory_anaemia n COSV51792673 COSM4384113 99426470 c.523A>G p.N175D Substitution - Missense 38 7:55146704-55146704 + - PATHOGENIC .986 Confirmed somatic variant 24030381 NS NS ENSP00000275493.2:p.Asn175Asp ENST00000275493.6:c.523A>G 7:g.55146704A>G EGFR ENST00000275493.6 3633 3236 2749050 2749050 2607753 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS n COSV51827262 COSM53226 99389764 c.2099A>G p.N700S Substitution - Missense 38 7:55173958-55173958 + - PATHOGENIC .97158 Confirmed somatic variant 29360550 surgery-fixed NS 69 ENSP00000275493.2:p.Asn700Ser ENST00000275493.6:c.2099A>G 7:g.55173958A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-24-2289-01 1475125 1398824 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51801941 COSM116797 133227675 c.2012A>G p.K671R Substitution - Missense het 38 7:55174006-55174006 + - PATHOGENIC .96091 Confirmed somatic variant 21720365 331 NS primary 68 ENSP00000415559.1:p.Lys671Arg ENST00000455089.5:c.2012A>G 7:g.55174006A>G EGFR ENST00000275493.6 3633 3236 TCGA-DK-AA75-01 2385754 2248586 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51771467 COSM7104388 99391630 c.1077C>A p.F359L Substitution - Missense 38 7:55156603-55156603 + - PATHOGENIC .96682 Confirmed somatic variant 413 NS primary 82 ENSP00000275493.2:p.Phe359Leu ENST00000275493.6:c.1077C>A 7:g.55156603C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CHG-2015-31289T 2634363 2494759 liver NS NS NS other neoplasm NS NS y COSV51783393 COSM6237886 132550198 c.2340G>T p.M780I Substitution - Missense 38 7:55191724-55191724 + - PATHOGENIC .9903 Confirmed somatic variant 660 NS primary 45 ENSP00000395243.3:p.Met780Ile ENST00000454757.6:c.2340G>T 7:g.55191724G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594190 1594190 1515164 upper_aerodigestive_tract pharynx oropharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 19726454 surgery fresh/frozen primary 70 ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787865 COSM6191461 99376561 c.3524A>T p.D1175V Substitution - Missense 38 7:55205508-55205508 + - PATHOGENIC .89387 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000275493.2:p.Asp1175Val ENST00000275493.6:c.3524A>T 7:g.55205508A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD6313a 1483843 1407469 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_ringed_sideroblasts NS n COSV51819755 COSM4384123 132612691 c.1466A>C p.E489A Substitution - Missense 38 7:55161601-55161601 + - PATHOGENIC .82008 Confirmed somatic variant 24030381 NS NS ENSP00000395243.3:p.Glu489Ala ENST00000454757.6:c.1466A>C 7:g.55161601A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008145-T02-IM5 2724310 2583131 breast NS NS NS carcinoma NS NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1461 2602435 2463311 large_intestine right NS NS carcinoma adenocarcinoma NS NS n COSV51813913 COSM6023901 132555174 c.344A>C p.N115T Substitution - Missense 38 7:55143408-55143408 + - PATHOGENIC .92454 Confirmed somatic variant 27121310 surgery fresh/frozen NS 47 ENSP00000395243.3:p.Asn115Thr ENST00000454757.6:c.344A>C 7:g.55143408A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812133 2812133 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV99289025 COSM9179905 133209408 c.2116A>G p.T706A Substitution - Missense 38 7:55174788-55174788 + - PATHOGENIC .9946 Confirmed somatic variant 31534501 circulating tumour NS 77 ENSP00000415559.1:p.Thr706Ala ENST00000455089.5:c.2116A>G 7:g.55174788A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1656173 1656173 1570830 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51772347 COSM17570 132552045 c.2087C>T p.P696L Substitution - Missense het 38 7:55174759-55174759 + - PATHOGENIC .9905 Confirmed somatic variant 21771097 surgery-fixed NS 64 ENSP00000395243.3:p.Pro696Leu ENST00000454757.6:c.2087C>T 7:g.55174759C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003679-T01-IM5 2720169 2578990 stomach gastroesophageal_junction NS NS carcinoma adenocarcinoma NS NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-6700-01 2120280 1994516 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772666 COSM3412205 133207076 c.2812G>A p.G938R Substitution - Missense 38 7:55201188-55201188 + - PATHOGENIC .98883 Confirmed somatic variant 329 NS NS 76 ENSP00000415559.1:p.Gly938Arg ENST00000455089.5:c.2812G>A 7:g.55201188G>A EGFR ENST00000275493.6 3633 3236 2625912 2625912 2486324 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51840645 COSM6191462 99396014 c.3562A>G p.K1188E Substitution - Missense 38 7:55205546-55205546 + - PATHOGENIC .89998 Confirmed somatic variant 25617745 surgery-fixed NS 66 ENSP00000275493.2:p.Lys1188Glu ENST00000275493.6:c.3562A>G 7:g.55205546A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006124-T01-IM5 2722503 2581324 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51842040 COSM6948138 132582516 c.942C>G p.F314L Substitution - Missense het 38 7:55156603-55156603 + - PATHOGENIC .96894 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Phe314Leu ENST00000454757.6:c.942C>G 7:g.55156603C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876608 2876608 2731123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 132560202 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876610 2876610 2731125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 132560202 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2254T>A 7:g.55181398T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 STC291 2404163 2267015 stomach NS NS NS carcinoma intestinal_adenocarcinoma NS NS y COSV51772123 COSM3266626 133206269 c.1894C>T p.R632C Substitution - Missense 38 7:55173092-55173092 + - PATHOGENIC .98355 Confirmed somatic variant 25042771 surgery fresh/frozen primary 75 ENSP00000415559.1:p.Arg632Cys ENST00000455089.5:c.1894C>T 7:g.55173092C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812094 2812094 2668557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 133206317 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Confirmed somatic variant 31534501 pleural effusion NS 63 ENSP00000415559.1:p.Arg731His ENST00000455089.5:c.2192G>A 7:g.55181336G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0876 2107991 1985852 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FG-A4MU-01 2194395 2062673 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 58 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914583 914583 832032 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51861444 COSM13007 132548215 c.2200_2201delinsTT p.G734F Substitution - Missense hom 38 7:55181344-55181345 + - Confirmed somatic variant 15788655 surgery fresh/frozen primary 81 ENSP00000395243.3:p.Gly734Phe ENST00000454757.6:c.2200_2201delinsTT 7:g.55181344_55181345delinsTT EGFR ENST00000275493.6 3633 3236 P-0008215-T01-IM5 2724369 2583190 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51834499 COSM6845063 99375657 c.964G>A p.G322S Substitution - Missense het 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly322Ser ENST00000275493.6:c.964G>A 7:g.55155904G>A EGFR ENST00000275493.6 3633 3236 2876608 2876608 2731123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832145 COSM6493936 99406880 c.2389T>G p.C797G Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95801 Confirmed somatic variant 29506987 circulating tumour NS ENSP00000275493.2:p.Cys797Gly ENST00000275493.6:c.2389T>G 7:g.55181398T>G EGFR ENST00000275493.6 3633 3236 2876616 2876616 2731131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105110312 COSM9869917 99412251 c.2152C>G p.L718V Substitution - Missense 38 7:55174011-55174011 + Yes PATHOGENIC .92276 Confirmed somatic variant 29506987 surgery fresh/frozen NS 76 ENSP00000275493.2:p.Leu718Val ENST00000275493.6:c.2152C>G 7:g.55174011C>G EGFR ENST00000275493.6 3633 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787547 COSM6191455 99376540 c.1126T>C p.F376L Substitution - Missense 38 7:55156652-55156652 + - PATHOGENIC .98052 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000275493.2:p.Phe376Leu ENST00000275493.6:c.1126T>C 7:g.55156652T>C EGFR ENST00000275493.6 3633 3236 TCGA-QC-A7B5-01 2270128 2136896 soft_tissue NS NS NS sarcoma NS NS NS y COSV51772347 COSM17570 99378871 c.2222C>T p.P741L Substitution - Missense 38 7:55174759-55174759 + - PATHOGENIC .9905 Confirmed somatic variant 635 NS NS ENSP00000275493.2:p.Pro741Leu ENST00000275493.6:c.2222C>T 7:g.55174759C>T EGFR ENST00000275493.6 3633 3236 P-0007037-T01-IM5 2830039 2685854 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843415 COSM6955777 99413808 c.1239C>A p.N413K Substitution - Missense 38 7:55157694-55157694 + - PATHOGENIC .97853 Confirmed somatic variant 30205045 surgery-fixed metastasis 57 ENSP00000275493.2:p.Asn413Lys ENST00000275493.6:c.1239C>A 7:g.55157694C>A EGFR ENST00000275493.6 3633 3236 EXTERN_MELA_20140924_131 2839485 2695251 skin scalp NS NS malignant_melanoma NS NS NS y COSV51806564 COSM6920868 99383183 c.2006G>A p.R669Q Substitution - Missense 38 7:55173069-55173069 + - PATHOGENIC .99699 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000275493.2:p.Arg669Gln ENST00000275493.6:c.2006G>A 7:g.55173069G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV99296123 COSM7997803 133229616 c.2614G>A p.G872R Substitution - Missense 38 7:55198764-55198764 + - PATHOGENIC .97508 Confirmed somatic variant 540 NS NS 90 ENSP00000415559.1:p.Gly872Arg ENST00000455089.5:c.2614G>A 7:g.55198764G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S0514 897600 815223 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 15118125 surgery - NOS primary ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152701 2152701 2021711 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 P-0003679-T01-IM5 2720169 2578990 stomach gastroesophageal_junction NS NS carcinoma adenocarcinoma NS NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 YUROC 2439362 2302203 skin NS NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 133212507 c.2890G>A p.D964N Substitution - Missense het 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 50 ENSP00000415559.1:p.Asp964Asn ENST00000455089.5:c.2890G>A 7:g.55201266G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002999-T01-IM3 2719208 2578029 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 132555528 c.620G>A p.R207H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg207His ENST00000454757.6:c.620G>A 7:g.55154018G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009260-T01-IM5 2725217 2584038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51771864 COSM6226 133211629 c.2191C>T p.R731C Substitution - Missense het 38 7:55181335-55181335 + - PATHOGENIC .97187 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg731Cys ENST00000455089.5:c.2191C>T 7:g.55181335C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 10677523 2751151 2609847 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV105822270 COSM9522396 133224431 c.1649G>C p.C550S Substitution - Missense 38 7:55165341-55165341 + - Confirmed somatic variant 29748005 circulating tumour NS ENSP00000415559.1:p.Cys550Ser ENST00000455089.5:c.1649G>C 7:g.55165341G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2842026 2842026 2697575 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 132559938 c.1339A>C p.S447R Substitution - Missense 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000395243.3:p.Ser447Arg ENST00000454757.6:c.1339A>C 7:g.55160314A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004117-T01-IM5 2720518 2579339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 P-0002999-T01-IM3 2783044 2640827 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 99382805 c.755G>A p.R252H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28825054 surgery-fixed primary 57 ENSP00000275493.2:p.Arg252His ENST00000275493.6:c.755G>A 7:g.55154018G>A EGFR ENST00000275493.6 3633 3236 GYWU_828 2771354 2629545 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51794659 COSM6652247 99401191 c.1720C>T p.R574W Substitution - Missense 38 7:55163821-55163821 + - PATHOGENIC .97962 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000275493.2:p.Arg574Trp ENST00000275493.6:c.1720C>T 7:g.55163821C>T SSTR5 ENST00000293897.5 1095 11334 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105876213 COSM10012794 98675161 c.1022G>A p.R341Q Substitution - Missense 38 16:1079890-1079890 + - PATHOGENIC .98032 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000293897.4:p.Arg341Gln ENST00000293897.5:c.1022G>A 16:g.1079890G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008215-T01-IM5 2724369 2583190 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51834499 COSM6845063 132548992 c.829G>A p.G277S Substitution - Missense het 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly277Ser ENST00000454757.6:c.829G>A 7:g.55155904G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV51778830 COSM1698691 133207060 c.1063G>A p.E355K Substitution - Missense 38 7:55156823-55156823 + - PATHOGENIC .99571 Confirmed somatic variant 540 NS NS 90 ENSP00000415559.1:p.Glu355Lys ENST00000455089.5:c.1063G>A 7:g.55156823G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-0155-01 1337821 1248206 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 99378201 c.910C>T p.H304Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 surgery fresh/frozen NS 61 ENSP00000275493.2:p.His304Tyr ENST00000275493.6:c.910C>T 7:g.55155850C>T EGFR ENST00000275493.6 3633 3236 914583 914583 832032 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51861444 COSM13007 99374834 c.2335_2336delinsTT p.G779F Substitution - Missense hom 38 7:55181344-55181345 + - Confirmed somatic variant 15788655 surgery fresh/frozen primary 81 ENSP00000275493.2:p.Gly779Phe ENST00000275493.6:c.2335_2336delinsTT 7:g.55181344_55181345delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982790 982790 898509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471549 1471549 1395288 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005003 1005003 922215 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812000 2812000 2668509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471535 1471535 1395274 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-97-A4M1-01 2385678 2248510 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS primary 52 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920106 920106 837185 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery-fixed NS 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2246145 2246145 2113419 lung left_lower_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25176975 surgery - NOS primary 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004993 1004993 922205 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1044285 1044285 960626 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471545 1471545 1395284 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1790530 1790530 1693509 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51780429 COSM710350 99385283 c.2612C>T p.A871V Substitution - Missense 38 7:55191861-55191861 + - PATHOGENIC .97911 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000275493.2:p.Ala871Val ENST00000275493.6:c.2612C>T 7:g.55191861C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003108-T01-IM5 2829558 2685373 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51866279 COSM6926300 132551487 c.530G>A p.R177H Substitution - Missense 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 30205045 surgery-fixed metastasis 37 ENSP00000395243.3:p.Arg177His ENST00000454757.6:c.530G>A 7:g.55152582G>A EGFR ENST00000275493.6 3633 3236 SK01600_P 1951898 1838690 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51835132 COSM1600351 99425952 c.977G>C p.C326S Substitution - Missense het 38 7:55155917-55155917 + - PATHOGENIC .99486 Confirmed somatic variant 23441165 surgery - NOS primary 57 ENSP00000275493.2:p.Cys326Ser ENST00000275493.6:c.977G>C 7:g.55155917G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 B72-S1 2732506 2591266 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 133216524 c.953C>T p.T318I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 29244145 surgery fresh/frozen primary 76.6 ENSP00000415559.1:p.Thr318Ile ENST00000455089.5:c.953C>T 7:g.55156614C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LICA-CN-HCC055T 2634102 2494498 liver NS NS NS other neoplasm NS NS y COSV51829036 COSM5823994 133227817 c.866G>C p.R289P Substitution - Missense 38 7:55155941-55155941 + - PATHOGENIC .84442 Confirmed somatic variant 660 NS primary 65 ENSP00000415559.1:p.Arg289Pro ENST00000455089.5:c.866G>C 7:g.55155941G>C EGFR ENST00000275493.6 3633 3236 2812133 2812133 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV99289025 COSM9179905 99381097 c.2251A>G p.T751A Substitution - Missense 38 7:55174788-55174788 + - PATHOGENIC .9946 Confirmed somatic variant 31534501 circulating tumour NS 77 ENSP00000275493.2:p.Thr751Ala ENST00000275493.6:c.2251A>G 7:g.55174788A>G EGFR ENST00000275493.6 3633 3236 TCGA-14-1034-02 2120293 1994529 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51775191 COSM1451530 99377057 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 329 NS NS 60 ENSP00000275493.2:p.Gly63Arg ENST00000275493.6:c.187G>A 7:g.55142384G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EXTERN_MELA_20140924_131 2839485 2695251 skin scalp NS NS malignant_melanoma NS NS NS y COSV104576577 COSM9396332 133218349 c.1256C>T p.S419L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000415559.1:p.Ser419Leu ENST00000455089.5:c.1256C>T 7:g.55160231C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006441-T01-IM5 2722817 2581638 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51775191 COSM1451530 132550172 c.187G>A p.G63R Substitution - Missense het 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly63Arg ENST00000454757.6:c.187G>A 7:g.55142384G>A EGFR ENST00000275493.6 3633 3236 P-0009243-T01-IM5 2725202 2584023 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51826157 COSM6967746 99460872 c.3323C>G p.P1108R Substitution - Missense het 38 7:55205307-55205307 + - PATHOGENIC .93931 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000275493.2:p.Pro1108Arg ENST00000275493.6:c.3323C>G 7:g.55205307C>G EGFR ENST00000275493.6 3633 3236 1091706 1091706 1006528 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26136 178380446 c.? p.G863S Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS ENSP00000275493.2:p.Gly863Ser EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DK-AA6L-01 2385744 2248576 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51816076 COSM53287 132568521 c.1996G>A p.E666K Substitution - Missense 38 7:55173990-55173990 + - PATHOGENIC .97511 Confirmed somatic variant 413 NS primary 48 ENSP00000395243.3:p.Glu666Lys ENST00000454757.6:c.1996G>A 7:g.55173990G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005725-T01-IM5 2722109 2580930 NS NS NS NS malignant_melanoma NS NS NS n COSV51776559 COSM4892884 132554171 c.298C>T p.P100S Substitution - Missense het 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Pro100Ser ENST00000454757.6:c.298C>T 7:g.55143362C>T EGFR ENST00000275493.6 3633 3236 1002749 1002749 919966 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20847 178389584 c.? p.L718P Substitution - Missense het + - Confirmed somatic variant 16115929 surgery-fixed NS 60 ENSP00000275493.2:p.Leu718Pro EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460138 1460138 1384015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790305 COSM13194 133206846 c.2405C>T p.T802I Substitution - Missense 38 7:55191789-55191789 + - PATHOGENIC .95119 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000415559.1:p.Thr802Ile ENST00000455089.5:c.2405C>T 7:g.55191789C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982860 982860 898579 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002649-T01-IM3 2829504 2685319 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51794834 COSM5575633 132558496 c.2738G>A p.R913H Substitution - Missense 38 7:55200340-55200340 + - PATHOGENIC .99504 Confirmed somatic variant 30205045 surgery-fixed primary 53 ENSP00000395243.3:p.Arg913His ENST00000454757.6:c.2738G>A 7:g.55200340G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004999 1004999 922211 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_C29 1863710 1754601 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914592 914592 832041 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 82 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A001-T-S02 2757355 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460136 1460136 1384013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007754-T01-IM5 2723998 2582819 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489238 1489238 1412396 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CGCRC167 2434467 2297344 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV105863926 COSM10049280 132567494 c.2759T>A p.I920N Substitution - Missense 38 7:55200361-55200361 + - PATHOGENIC .96814 Confirmed somatic variant 26416732 surgery - NOS primary 81 ENSP00000395243.3:p.Ile920Asn ENST00000454757.6:c.2759T>A 7:g.55200361T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003096-T01-IM5 2719590 2578411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2729883 2729883 2588657 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS n COSM6997541 178388468 c.? p.D837Y Substitution - Missense + - Confirmed somatic variant 29487225 circulating tumour NS EGFR ENST00000275493.6 3633 3236 TCGA-25-2404-01 1474989 1398688 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV99292585 COSM7509017 99389217 c.1381G>A p.V461M Substitution - Missense 38 7:55160221-55160221 + - PATHOGENIC .98193 Confirmed somatic variant 331 NS primary 38 ENSP00000275493.2:p.Val461Met ENST00000275493.6:c.1381G>A 7:g.55160221G>A EGFR ENST00000275493.6 3633 3236 TCGA-25-2404-01 1474989 1398688 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV99292585 COSM7509017 99389217 c.1381G>A p.V461M Substitution - Missense 38 7:55160221-55160221 + - PATHOGENIC .98193 Confirmed somatic variant 21720365 331 NS primary 38 ENSP00000275493.2:p.Val461Met ENST00000275493.6:c.1381G>A 7:g.55160221G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002489-T01-IM3 2718761 2577582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 ILMN13 2816773 2673124 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51797307 COSM1090871 132567606 c.1175C>A p.S392Y Substitution - Missense 38 7:55160150-55160150 + - PATHOGENIC .98943 Confirmed somatic variant 29937994 surgery fresh/frozen NS 54 ENSP00000395243.3:p.Ser392Tyr ENST00000454757.6:c.1175C>A 7:g.55160150C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0013082-T01-IM5 2803825 2660575 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51769863 COSM1090888 133209747 c.2089G>A p.V697I Substitution - Missense het 38 7:55174761-55174761 + - PATHOGENIC .99624 Confirmed somatic variant 29316426 surgery-fixed primary 41 ENSP00000415559.1:p.Val697Ile ENST00000455089.5:c.2089G>A 7:g.55174761G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-A6-3809-01 1901050 1789730 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51844677 COSM6984453 133225084 c.2864C>T p.A955V Substitution - Missense 38 7:55201240-55201240 + - PATHOGENIC .95761 Confirmed somatic variant 376 fresh/frozen - NOS primary 71 ENSP00000415559.1:p.Ala955Val ENST00000455089.5:c.2864C>T 7:g.55201240C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T521 2658729 2518888 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51769243 COSM6652288 132592114 c.2167A>G p.S723G Substitution - Missense 38 7:55181311-55181311 + - PATHOGENIC .97311 Confirmed somatic variant 27149842 NS NS 62.83 ENSP00000395243.3:p.Ser723Gly ENST00000454757.6:c.2167A>G 7:g.55181311A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-76-6282-01 2120389 1994625 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51810174 COSM3412190 132554952 c.1577G>C p.C526S Substitution - Missense 38 7:55163813-55163813 + - PATHOGENIC .99637 Confirmed somatic variant 329 NS NS 63 ENSP00000395243.3:p.Cys526Ser ENST00000454757.6:c.1577G>C 7:g.55163813G>C EGFR ENST00000275493.6 3633 3236 2862938 2862938 2718100 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM4766152 178379591 c.? p.R324L Substitution - Missense + - Confirmed somatic variant 26486077 surgery fresh/frozen NS 74 ENSP00000275493.2:p.Arg324Leu EGFR ENST00000275493.6 3633 3236 TCGA-28-1752-01 2178270 2046568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 42 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-28-1752-01 2178270 2046568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 329 NS NS 42 ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 P-0006612-T01-IM5 2722991 2581812 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51843352 COSM6950555 99413778 c.530C>T p.S177L Substitution - Missense het 38 7:55146711-55146711 + - NEUTRAL .28714 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ser177Leu ENST00000275493.6:c.530C>T 7:g.55146711C>T EGFR ENST00000275493.6 3633 3236 TCGA-CA-5254-01 1651181 1565968 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV99289896 COSM7552012 99425819 c.3016G>A p.D1006N Substitution - Missense 38 7:55201257-55201257 + - PATHOGENIC .98884 Confirmed somatic variant 376 NS NS 42 ENSP00000275493.2:p.Asp1006Asn ENST00000275493.6:c.3016G>A 7:g.55201257G>A EGFR ENST00000275493.6 3633 3236 2812133 2812133 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51829458 COSM51497 99381092 c.2237_2238inv p.E746V Substitution - Missense 38 7:55174774-55174775 + - Confirmed somatic variant 31534501 circulating tumour NS 77 ENSP00000275493.2:p.Glu746Val ENST00000275493.6:c.2237_2238inv 7:g.55174774_55174775inv EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-OL-A5RZ-01 2187696 2055974 breast NS NS NS carcinoma NS NS NS y COSV99288978 COSM7695792 132566825 c.289G>C p.E97Q Substitution - Missense 38 7:55143353-55143353 + - PATHOGENIC .94007 Confirmed somatic variant 414 NS NS 57 ENSP00000395243.3:p.Glu97Gln ENST00000454757.6:c.289G>C 7:g.55143353G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876608 2876608 2731123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 132563564 c.2240T>A p.L747H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Confirmed somatic variant 29506987 circulating tumour NS ENSP00000395243.3:p.Leu747His ENST00000454757.6:c.2240T>A 7:g.55181384T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876610 2876610 2731125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 132563564 c.2240T>A p.L747H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000395243.3:p.Leu747His ENST00000454757.6:c.2240T>A 7:g.55181384T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007319-T01-IM5 2723658 2582479 penis NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51785510 COSM6957413 133202339 c.967G>A p.D323N Substitution - Missense het 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Asp323Asn ENST00000455089.5:c.967G>A 7:g.55156628G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002649-T01-IM3 2718895 2577716 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51794834 COSM5575633 133214600 c.2738G>A p.R913H Substitution - Missense het 38 7:55200340-55200340 + - PATHOGENIC .99504 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg913His ENST00000455089.5:c.2738G>A 7:g.55200340G>A EGFR ENST00000275493.6 3633 3236 TCGA-BR-8680-01 2197966 2066244 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51785413 COSM1176673 99382805 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 541 NS NS 45 ENSP00000275493.2:p.Arg252His ENST00000275493.6:c.755G>A 7:g.55154018G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AA-3518-01 1650979 1565766 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51816226 COSM291680 132585024 c.2389A>C p.N797H Substitution - Missense 38 7:55191773-55191773 + - PATHOGENIC .98756 Confirmed somatic variant 22810696 376 NS NS 81 ENSP00000395243.3:p.Asn797His ENST00000454757.6:c.2389A>C 7:g.55191773A>C EGFR ENST00000275493.6 3633 3236 P-0011226-T01-IM5 2726843 2585664 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51842174 COSM6979569 99384299 c.1610A>T p.D537V Substitution - Missense het 38 7:55161610-55161610 + - PATHOGENIC .78722 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Asp537Val ENST00000275493.6:c.1610A>T 7:g.55161610A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 J36 2815364 2671744 central_nervous_system brain NS NS glioma astrocytoma_Grade_II fibrillary NS y COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 29263181 surgery fresh/frozen NS 48 ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0174-01 1910190 1798481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51773690 COSM3412198 133266400 c.1706G>A p.G569D Substitution - Missense 38 7:55165398-55165398 + - NEUTRAL .00947 Confirmed somatic variant 329 fresh/frozen - NOS primary 54 ENSP00000415559.1:p.Gly569Asp ENST00000455089.5:c.1706G>A 7:g.55165398G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0876 2107991 1985852 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FG-A4MU-01 2194395 2062673 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 58 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-RS 2060455 1940662 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma Richter_transformation NS y COSV51773206 COSM28603 132560955 c.2158G>A p.V720M Substitution - Missense 38 7:55181302-55181302 + - PATHOGENIC .97963 Confirmed somatic variant 24127483 blood-bone marrow primary 69 ENSP00000395243.3:p.Val720Met ENST00000454757.6:c.2158G>A 7:g.55181302G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-A6-3809-01 1901050 1789730 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51844677 COSM6984453 132568098 c.2864C>T p.A955V Substitution - Missense 38 7:55201240-55201240 + - PATHOGENIC .95761 Confirmed somatic variant 376 fresh/frozen - NOS primary 71 ENSP00000395243.3:p.Ala955Val ENST00000454757.6:c.2864C>T 7:g.55201240C>T EGFR ENST00000275493.6 3633 3236 P-0006612-T01-IM5 2722991 2581812 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51843392 COSM6952229 99413800 c.3195C>A p.F1065L Substitution - Missense het 38 7:55202549-55202549 + - .58744 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Phe1065Leu ENST00000275493.6:c.3195C>A 7:g.55202549C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006713-T01-IM5 2723092 2581913 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51784387 COSM6953025 133269417 c.70G>T p.A24S Substitution - Missense het 38 7:55019347-55019347 + - NEUTRAL .37583 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ala24Ser ENST00000455089.5:c.70G>T 7:g.55019347G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1179542 1179542 1091504 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51768413 COSM25861 132592094 c.2139A>C p.E713D Substitution - Missense het 38 7:55174811-55174811 + - PATHOGENIC .88475 Confirmed somatic variant 18985444 surgery - NOS primary 72 ENSP00000395243.3:p.Glu713Asp ENST00000454757.6:c.2139A>C 7:g.55174811A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-28-1752-01 2178270 2046568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 42 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 P-0008179-T01-IM5 2724346 2583167 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 99380942 c.1774G>A p.V592I Substitution - Missense het 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Val592Ile ENST00000275493.6:c.1774G>A 7:g.55165331G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T1849 2658271 2518430 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51794620 COSM6652251 132592666 c.46G>A p.A16T Substitution - Missense 38 7:55019323-55019323 + - NEUTRAL .21777 Confirmed somatic variant 27149842 NS NS 79.25 ENSP00000395243.3:p.Ala16Thr ENST00000454757.6:c.46G>A 7:g.55019323G>A EGFR ENST00000275493.6 3633 3236 TCGA-E5-A2PC-01 1898110 1786794 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51779680 COSM1313184 99406235 c.1151C>G p.T384S Substitution - Missense 38 7:55156776-55156776 + - PATHOGENIC .98418 Confirmed somatic variant 413 fresh/frozen - NOS primary 61 ENSP00000275493.2:p.Thr384Ser ENST00000275493.6:c.1151C>G 7:g.55156776C>G EGFR ENST00000275493.6 3633 3236 P-0007037-T01-IM5 2723412 2582233 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843415 COSM6955777 99413808 c.1239C>A p.N413K Substitution - Missense het 38 7:55157694-55157694 + - PATHOGENIC .97853 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Asn413Lys ENST00000275493.6:c.1239C>A 7:g.55157694C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-32-1982-01 1338091 1248476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 76 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 J80_T 2194988 2063266 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51805367 COSM3950642 132575213 c.904G>A p.D302N Substitution - Missense 38 7:55156565-55156565 + - PATHOGENIC .82248 Confirmed somatic variant 583 NS NS ENSP00000395243.3:p.Asp302Asn ENST00000454757.6:c.904G>A 7:g.55156565G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BB-A5HY-01 2385721 2248553 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99289265 COSM8389919 132606133 c.1120G>C p.A374P Substitution - Missense 38 7:55157710-55157710 + - PATHOGENIC .9183 Confirmed somatic variant 627 NS primary 64 ENSP00000395243.3:p.Ala374Pro ENST00000454757.6:c.1120G>C 7:g.55157710G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BB-A5HY-01 2385721 2248553 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99289265 COSM8389919 133270747 c.1120G>C p.A374P Substitution - Missense 38 7:55157710-55157710 + - PATHOGENIC .9183 Confirmed somatic variant 627 NS primary 64 ENSP00000415559.1:p.Ala374Pro ENST00000455089.5:c.1120G>C 7:g.55157710G>C EGFR ENST00000275493.6 3633 3236 TCGA-A6-3809-01 1901050 1789730 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51814970 COSM6942061 99420537 c.3454G>A p.D1152N Substitution - Missense 38 7:55205438-55205438 + - .52145 Confirmed somatic variant 376 fresh/frozen - NOS primary 71 ENSP00000275493.2:p.Asp1152Asn ENST00000275493.6:c.3454G>A 7:g.55205438G>A EGFR ENST00000275493.6 3633 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51865283 COSM6970485 99452412 c.188G>A p.G63E Substitution - Missense het 38 7:55142385-55142385 + - PATHOGENIC .95671 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Gly63Glu ENST00000275493.6:c.188G>A 7:g.55142385G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000913-T03-IM5 2719384 2578205 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007037-T01-IM5 2830039 2685854 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843415 COSM6955777 132579240 c.1104C>A p.N368K Substitution - Missense 38 7:55157694-55157694 + - PATHOGENIC .97853 Confirmed somatic variant 30205045 surgery-fixed metastasis 57 ENSP00000395243.3:p.Asn368Lys ENST00000454757.6:c.1104C>A 7:g.55157694C>A EGFR ENST00000275493.6 3633 3236 TCGA-26-5139 2108061 1985922 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51840469 COSM2157152 99433926 c.1883G>T p.C628F Substitution - Missense 38 7:55171177-55171177 + - PATHOGENIC .98352 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Cys628Phe ENST00000275493.6:c.1883G>T 7:g.55171177G>T EGFR ENST00000275493.6 3633 3236 LICA-CN-HCC055T 2634102 2494498 liver NS NS NS other neoplasm NS NS y COSV51829036 COSM5823994 99402231 c.1001G>C p.R334P Substitution - Missense 38 7:55155941-55155941 + - PATHOGENIC .84442 Confirmed somatic variant 660 NS primary 65 ENSP00000275493.2:p.Arg334Pro ENST00000275493.6:c.1001G>C 7:g.55155941G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007100-T01-IM5 2723473 2582294 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51776957 COSM6955986 132587401 c.2986A>G p.T996A Substitution - Missense het 38 7:55201741-55201741 + - PATHOGENIC .92147 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr996Ala ENST00000454757.6:c.2986A>G 7:g.55201741A>G EGFR ENST00000275493.6 3633 3236 2150414 2150414 2019483 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 66 ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-26-5139 2108061 1985922 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51840469 COSM2157152 132594161 c.1748G>T p.C583F Substitution - Missense 38 7:55171177-55171177 + - PATHOGENIC .98352 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Cys583Phe ENST00000454757.6:c.1748G>T 7:g.55171177G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876643 2876643 2731158 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51795112 COSM23633 132573436 c.2141T>A p.I714N Substitution - Missense 38 7:55174813-55174813 + - PATHOGENIC .99182 Confirmed somatic variant 29506987 circulating tumour NS 36 ENSP00000395243.3:p.Ile714Asn ENST00000454757.6:c.2141T>A 7:g.55174813T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008450-T01-IM5 2724567 2583388 skin NS NS NS malignant_melanoma NS NS NS n COSV51822498 COSM3266565 132578509 c.782C>T p.S261L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ser261Leu ENST00000454757.6:c.782C>T 7:g.55155857C>T EGFR ENST00000275493.6 3633 3236 P-0008346-T01-IM5 2724474 2583295 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51838649 COSM6962468 99418377 c.412A>G p.R138G Substitution - Missense het 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg138Gly ENST00000275493.6:c.412A>G 7:g.55143476A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 3101B7_035_T 2390296 2253128 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51811266 COSM5041204 133233968 c.385A>G p.K129E Substitution - Missense 38 7:55143449-55143449 + - PATHOGENIC .9498 Confirmed somatic variant 25159915 NS NS ENSP00000415559.1:p.Lys129Glu ENST00000455089.5:c.385A>G 7:g.55143449A>G EGFR ENST00000275493.6 3633 3236 P-0009260-T01-IM5 2725217 2584038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51771864 COSM6226 99383011 c.2326C>T p.R776C Substitution - Missense het 38 7:55181335-55181335 + - PATHOGENIC .97187 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg776Cys ENST00000275493.6:c.2326C>T 7:g.55181335C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1165893 1165893 1078207 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51785733 COSM28575 133235090 c.2515G>A p.E839K Substitution - Missense het 38 7:55192790-55192790 + - PATHOGENIC .9655 Confirmed somatic variant 16407879 cerebrospinal fluid metastasis 70 ENSP00000415559.1:p.Glu839Lys ENST00000455089.5:c.2515G>A 7:g.55192790G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BH-A18U-01 1899961 1788645 breast NS NS NS carcinoma NS NS NS y COSV99294745 COSM7670588 132580251 c.634G>A p.E212K Substitution - Missense 38 7:55154032-55154032 + - PATHOGENIC .97243 Confirmed somatic variant 414 fresh/frozen - NOS primary 72 ENSP00000395243.3:p.Glu212Lys ENST00000454757.6:c.634G>A 7:g.55154032G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004944-T02-IM5 2721354 2580175 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843300 COSM6949613 132579197 c.802G>T p.A268S Substitution - Missense het 38 7:55155877-55155877 + - NEUTRAL .06397 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Ala268Ser ENST00000454757.6:c.802G>T 7:g.55155877G>T EGFR ENST00000275493.6 3633 3236 T1849 2658271 2518430 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51794620 COSM6652251 99431944 c.46G>A p.A16T Substitution - Missense 38 7:55019323-55019323 + - NEUTRAL .21777 Confirmed somatic variant 27149842 NS NS 79.25 ENSP00000275493.2:p.Ala16Thr ENST00000275493.6:c.46G>A 7:g.55019323G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-32-1982-01 1338091 1248476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 76 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 1091709 1091709 1006531 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26131 178380442 c.? p.E746V Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS ENSP00000275493.2:p.Glu746Val EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV99296122 COSM7997831 133229610 c.2209C>T p.L737F Substitution - Missense 38 7:55181353-55181353 + - PATHOGENIC .94073 Confirmed somatic variant 540 NS NS 90 ENSP00000415559.1:p.Leu737Phe ENST00000455089.5:c.2209C>T 7:g.55181353C>T EGFR ENST00000275493.6 3633 3236 TCGA-06-0174-01 1910190 1798481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 fresh/frozen - NOS primary 54 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T1849 2658271 2518430 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51794659 COSM6652247 132569255 c.1585C>T p.R529W Substitution - Missense 38 7:55163821-55163821 + - PATHOGENIC .97962 Confirmed somatic variant 27149842 NS NS 79.25 ENSP00000395243.3:p.Arg529Trp ENST00000454757.6:c.1585C>T 7:g.55163821C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801711 COSM3923810 133255860 c.772G>A p.D258N Substitution - Missense 38 7:55155847-55155847 + - PATHOGENIC .99324 Confirmed somatic variant 540 NS NS 68 ENSP00000415559.1:p.Asp258Asn ENST00000455089.5:c.772G>A 7:g.55155847G>A EGFR ENST00000275493.6 3633 3236 1471534 1471534 1395273 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0008744-T02-IM5 2724794 2583615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206718 1206718 1118596 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1179551 1179551 1091513 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 55 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982850 982850 898569 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489255 1489255 1412413 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876616 2876616 2731131 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 surgery fresh/frozen NS 76 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 EXTERN_MELA_20140924_001 2839320 2695086 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51781835 COSM174732 99379122 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28467829 cell-line metastasis ENSP00000275493.2:p.Glu114Lys ENST00000275493.6:c.340G>A 7:g.55143404G>A EGFR ENST00000275493.6 3633 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV99296117 COSM7998157 99403761 c.1950G>A p.M650I Substitution - Missense 38 7:55173013-55173013 + - NEUTRAL .06549 Confirmed somatic variant 540 NS NS 90 ENSP00000275493.2:p.Met650Ile ENST00000275493.6:c.1950G>A 7:g.55173013G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001278-T01-IM3 2716974 2575795 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51844468 COSM6916179 133225017 c.308A>T p.N103I Substitution - Missense het 38 7:55143372-55143372 + - PATHOGENIC .97828 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Asn103Ile ENST00000455089.5:c.308A>T 7:g.55143372A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1079263 1079263 994483 soft_tissue fibrous_tissue_and_uncertain_origin kidney NS malignant_melanoma_of_soft_parts-clear_cell_sarcoma NS NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 17646270 surgery - NOS NS 1.8 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003213-T01-IM5 2719708 2578529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211135 1211135 1123003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 53 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51781835 COSM174732 133207258 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Glu114Lys ENST00000455089.5:c.340G>A 7:g.55143404G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BP-4354-01 2120471 1994707 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51815927 COSM24971 132563635 c.2378T>C p.L793P Substitution - Missense 38 7:55191762-55191762 + - PATHOGENIC .97813 Confirmed somatic variant 416 NS NS 40 ENSP00000395243.3:p.Leu793Pro ENST00000454757.6:c.2378T>C 7:g.55191762T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003108-T01-IM5 2719604 2578425 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51866279 COSM6926300 133206418 c.530G>A p.R177H Substitution - Missense het 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000415559.1:p.Arg177His ENST00000455089.5:c.530G>A 7:g.55152582G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006612-T01-IM5 2722991 2581812 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51843392 COSM6952229 133240027 c.3060C>A p.F1020L Substitution - Missense het 38 7:55202549-55202549 + - .58744 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Phe1020Leu ENST00000455089.5:c.3060C>A 7:g.55202549C>A EGFR ENST00000275493.6 3633 3236 920013 920013 837092 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51802272 COSM13425 99394305 c.2305G>A p.V769M Substitution - Missense het 38 7:55181314-55181314 + - PATHOGENIC .98024 Confirmed somatic variant 15623594 surgery fresh/frozen NS 62 ENSP00000275493.2:p.Val769Met ENST00000275493.6:c.2305G>A 7:g.55181314G>A EGFR ENST00000275493.6 3633 3236 P-0000913-T03-IM5 2719384 2578205 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001261 1001261 918484 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982789 982789 898508 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006713-T01-IM5 2723092 2581913 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51784387 COSM6953025 132604790 c.70G>T p.A24S Substitution - Missense het 38 7:55019347-55019347 + - NEUTRAL .37583 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ala24Ser ENST00000454757.6:c.70G>T 7:g.55019347G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007037-T01-IM5 2723412 2582233 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843415 COSM6955777 132579240 c.1104C>A p.N368K Substitution - Missense het 38 7:55157694-55157694 + - PATHOGENIC .97853 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Asn368Lys ENST00000454757.6:c.1104C>A 7:g.55157694C>A EGFR ENST00000275493.6 3633 3236 KD514 1005018 922230 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 1690853 1690853 1599120 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 99388924 c.1476C>A p.S492R Substitution - Missense 38 7:55160316-55160316 + - NEUTRAL .35843 Confirmed somatic variant 22270724 surgery - NOS recurrent 52 ENSP00000275493.2:p.Ser492Arg ENST00000275493.6:c.1476C>A 7:g.55160316C>A EGFR ENST00000275493.6 3633 3236 1471563 1471563 1395302 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004117-T01-IM5 2720518 2579339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51865345 COSM6970489 133276015 c.1042G>A p.D348N Substitution - Missense het 38 7:55156802-55156802 + - PATHOGENIC .91392 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Asp348Asn ENST00000455089.5:c.1042G>A 7:g.55156802G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002999-T01-IM3 2783044 2640827 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 133211383 c.620G>A p.R207H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28825054 surgery-fixed primary 57 ENSP00000415559.1:p.Arg207His ENST00000455089.5:c.620G>A 7:g.55154018G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011226-T01-IM5 2726843 2585664 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51842174 COSM6979569 132556840 c.1475A>T p.D492V Substitution - Missense het 38 7:55161610-55161610 + - PATHOGENIC .78722 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Asp492Val ENST00000454757.6:c.1475A>T 7:g.55161610A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KD514 1005018 922230 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 CRC65 2730847 2589616 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV105863705 COSM10062224 99373747 c.193T>G p.L65V Substitution - Missense 38 7:55142390-55142390 + - PATHOGENIC .83273 Confirmed somatic variant 26416732 xenograft metastasis 45 ENSP00000275493.2:p.Leu65Val ENST00000275493.6:c.193T>G 7:g.55142390T>G EGFR ENST00000275493.6 3633 3236 PD6313a 1483843 1407469 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_ringed_sideroblasts NS n COSV51819755 COSM4384123 99453035 c.1601A>C p.E534A Substitution - Missense 38 7:55161601-55161601 + - PATHOGENIC .82008 Confirmed somatic variant 24030381 NS NS ENSP00000275493.2:p.Glu534Ala ENST00000275493.6:c.1601A>C 7:g.55161601A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002489-T01-IM3 2718761 2577582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001649-T01-IM3 2717717 2576538 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS n COSV51792269 COSM6918047 133239566 c.2308C>T p.L770F Substitution - Missense het 38 7:55181452-55181452 + - PATHOGENIC .96277 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu770Phe ENST00000455089.5:c.2308C>T 7:g.55181452C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000435-T01-IM3 2786865 2644288 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51776947 COSM6910370 133220707 c.2362T>A p.L788M Substitution - Missense 38 7:55191746-55191746 + - NEUTRAL .36784 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000415559.1:p.Leu788Met ENST00000455089.5:c.2362T>A 7:g.55191746T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982876 982876 898595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1044283 1044283 960624 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489249 1489249 1412407 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004996 1004996 922208 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471537 1471537 1395276 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152785 2152785 2021795 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876059 2876059 2730574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 77 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CGCRC167 2434467 2297344 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV105863924 COSM10049276 133224182 c.905A>T p.D302V Substitution - Missense 38 7:55156566-55156566 + - PATHOGENIC .89104 Confirmed somatic variant 26416732 surgery - NOS primary 81 ENSP00000415559.1:p.Asp302Val ENST00000455089.5:c.905A>T 7:g.55156566A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PCSI_0588_Pa_P_526 2507080 2369416 pancreas NS NS NS carcinoma NS NS NS y COSV51770777 COSM28286 132563968 c.2359C>T p.R787C Substitution - Missense 38 7:55191743-55191743 + - PATHOGENIC .95135 Confirmed somatic variant 382 NS primary 78 ENSP00000395243.3:p.Arg787Cys ENST00000454757.6:c.2359C>T 7:g.55191743C>T EGFR ENST00000275493.6 3633 3236 2876610 2876610 2731125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 99378223 c.2327G>A p.R776H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000275493.2:p.Arg776His ENST00000275493.6:c.2327G>A 7:g.55181336G>A EGFR ENST00000275493.6 3633 3236 P-0008179-T02-IM5 2830115 2685930 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 99380942 c.1774G>A p.V592I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000275493.2:p.Val592Ile ENST00000275493.6:c.1774G>A 7:g.55165331G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004688-T01-IM5 2721089 2579910 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51823965 COSM6937748 132572087 c.76G>A p.E26K Substitution - Missense het 38 7:55019353-55019353 + - PATHOGENIC .70393 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Glu26Lys ENST00000454757.6:c.76G>A 7:g.55019353G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SK01600_P 1951898 1838690 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51835132 COSM1600351 133249873 c.842G>C p.C281S Substitution - Missense het 38 7:55155917-55155917 + - PATHOGENIC .99486 Confirmed somatic variant 23441165 surgery - NOS primary 57 ENSP00000415559.1:p.Cys281Ser ENST00000455089.5:c.842G>C 7:g.55155917G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EXTERN_MELA_20140526_084 2839361 2695127 skin trunk NS NS malignant_melanoma NS NS NS y COSV104577151 COSM9446111 132565313 c.2087_2088delinsGT p.P696R Substitution - Missense 38 7:55174759-55174760 + - Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000395243.3:p.Pro696Arg ENST00000454757.6:c.2087_2088delinsGT 7:g.55174759_55174760delinsGT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-28-1752-01 2178270 2046568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 42 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 P-0007663-T01-IM5 2723937 2582758 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920021 920021 837100 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0003213-T01-IM5 2719708 2578529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1211135 1211135 1123003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 53 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2811961 2811961 2668496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 78 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471567 1471567 1395306 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 914584 914584 832033 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 80 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2812090 2812090 2668555 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 79 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458695 1458695 1382670 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982856 982856 898575 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1004994 1004994 922206 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0008705-T01-IM5 2724760 2583581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0009260-T01-IM5 2725217 2584038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0004328-T01-IM5 2720736 2579557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S06-38853-TP 2366573 2229456 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51792018 COSM4992972 132551365 c.2999C>T p.S1000F Substitution - Missense het 38 7:55201754-55201754 + - PATHOGENIC .97067 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000395243.3:p.Ser1000Phe ENST00000454757.6:c.2999C>T 7:g.55201754C>T EGFR ENST00000275493.6 3633 3236 2876596 2876596 2731111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 99392475 c.2390G>C p.C797S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 64 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2390G>C 7:g.55181399G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0142-01 2120247 1994483 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 81 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003070-T02-IM5 2719579 2578400 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2819297 2819297 2675596 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 30711944 pleural effusion recurrent 73 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468623 1468623 1392374 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM53179 178383575 c.? p.V834L Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Val834Leu EGFR ENST00000275493.6 3633 3236 2115533 2115533 1989777 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194726 1194726 1106621 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767280 COSM133183 132563720 c.2007G>C p.K669N Substitution - Missense 38 7:55174001-55174001 + - PATHOGENIC .89357 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000395243.3:p.Lys669Asn ENST00000454757.6:c.2007G>C 7:g.55174001G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876596 2876596 2731111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 64 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CRC65 2730847 2589616 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV105863705 COSM10062224 133202463 c.193T>G p.L65V Substitution - Missense 38 7:55142390-55142390 + - PATHOGENIC .83273 Confirmed somatic variant 26416732 xenograft metastasis 45 ENSP00000415559.1:p.Leu65Val ENST00000455089.5:c.193T>G 7:g.55142390T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-0707-01 2178095 2046393 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 132552126 c.674A>G p.Y225C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 329 NS NS 55 ENSP00000395243.3:p.Tyr225Cys ENST00000454757.6:c.674A>G 7:g.55154072A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801732 COSM3923812 133255873 c.956C>T p.S319F Substitution - Missense 38 7:55156617-55156617 + - NEUTRAL .433 Confirmed somatic variant 540 NS NS 68 ENSP00000415559.1:p.Ser319Phe ENST00000455089.5:c.956C>T 7:g.55156617C>T EGFR ENST00000275493.6 3633 3236 2777771 2777771 2635906 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSM7408751 178389264 c.? p.T302I Substitution - Missense + - Confirmed somatic variant 30041611 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51865345 COSM6970489 99452447 c.1177G>A p.D393N Substitution - Missense het 38 7:55156802-55156802 + - PATHOGENIC .91392 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Asp393Asn ENST00000275493.6:c.1177G>A 7:g.55156802G>A EGFR ENST00000275493.6 3633 3236 P-0013082-T01-IM5 2803825 2660575 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51769863 COSM1090888 99381430 c.2224G>A p.V742I Substitution - Missense het 38 7:55174761-55174761 + - PATHOGENIC .99624 Confirmed somatic variant 29316426 surgery-fixed primary 41 ENSP00000275493.2:p.Val742Ile ENST00000275493.6:c.2224G>A 7:g.55174761G>A EGFR ENST00000275493.6 3633 3236 P-0003213-T01-IM5 2719708 2578529 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1211135 1211135 1123003 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 53 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1079263 1079263 994483 soft_tissue fibrous_tissue_and_uncertain_origin kidney NS malignant_melanoma_of_soft_parts-clear_cell_sarcoma NS NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 17646270 surgery - NOS NS 1.8 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T3010 2658443 2518602 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 132556268 c.1445G>A p.R482Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 74.08 ENSP00000395243.3:p.Arg482Gln ENST00000454757.6:c.1445G>A 7:g.55161580G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EE-A2MR-06 2121688 1995924 skin NS NS NS malignant_melanoma NS NS NS y COSV51788720 COSM3639737 132594187 c.1399C>T p.P467S Substitution - Missense 38 7:55161534-55161534 + - NEUTRAL .03494 Confirmed somatic variant 540 NS NS 61 ENSP00000395243.3:p.Pro467Ser ENST00000454757.6:c.1399C>T 7:g.55161534C>T EGFR ENST00000275493.6 3633 3236 2150414 2150414 2019483 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 66 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471555 1471555 1395294 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005845-T02-IM5 2722231 2581052 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 25 897186 814809 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876066 2876066 2730581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489251 1489251 1412409 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920028 920028 837107 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 53 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003096-T01-IM5 2719590 2578411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 EXTERN_MELA_20140924_131 2839485 2695251 skin scalp NS NS malignant_melanoma NS NS NS y COSV104576577 COSM9396332 99390660 c.1391C>T p.S464L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000275493.2:p.Ser464Leu ENST00000275493.6:c.1391C>T 7:g.55160231C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MBC_174 2662675 2522799 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS y COSV51792227 COSM6582372 133209733 c.2524T>A p.L842I Substitution - Missense 38 7:55192799-55192799 + - PATHOGENIC .84827 Confirmed somatic variant 28027327 fresh/frozen - NOS NS ENSP00000415559.1:p.Leu842Ile ENST00000455089.5:c.2524T>A 7:g.55192799T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0174-01 1910190 1798481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 fresh/frozen - NOS primary 54 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BR-8680-01 2197966 2066244 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51785413 COSM1176673 133211383 c.620G>A p.R207H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 541 NS NS 45 ENSP00000415559.1:p.Arg207His ENST00000455089.5:c.620G>A 7:g.55154018G>A EGFR ENST00000275493.6 3633 3236 TCGA-AA-3966-01 1651077 1565864 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51801471 COSM53105 99379999 c.2492G>A p.R831H Substitution - Missense 38 7:55191741-55191741 + - PATHOGENIC .96289 Confirmed somatic variant 22810696 376 NS NS 89 ENSP00000275493.2:p.Arg831His ENST00000275493.6:c.2492G>A 7:g.55191741G>A EGFR ENST00000275493.6 3633 3236 1468096 1468096 1391942 peritoneum NS NS NS mesothelioma NS NS NS n COSV51771943 COSM22953 99401367 c.2401T>C p.Y801H Substitution - Missense het 38 7:55181410-55181410 + - PATHOGENIC .96426 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000275493.2:p.Tyr801His ENST00000275493.6:c.2401T>C 7:g.55181410T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489248 1489248 1412406 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000280-T01-IM3 2714952 2573773 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 112503 1520680 1443055 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20668451 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-06-0142-01 2120247 1994483 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 81 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004342-T01-IM5 2720749 2579570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1063622 1063622 979667 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 53 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KD514 1005018 922230 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876610 2876610 2731125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009864-T01-IM5 2725703 2584524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001258 1001258 918481 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920023 920023 837102 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 82 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458701 1458701 1382676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 IGC-02-1054 2662276 2522400 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51834398 COSM6536253 132620567 c.3144A>G p.I1048M Substitution - Missense 38 7:55205263-55205263 + - NEUTRAL .43211 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000395243.3:p.Ile1048Met ENST00000454757.6:c.3144A>G 7:g.55205263A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 IGC-03-1030 2662287 2522411 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51787961 COSM6530131 132575474 c.1760G>C p.G587A Substitution - Missense 38 7:55171189-55171189 + - PATHOGENIC .98448 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000395243.3:p.Gly587Ala ENST00000454757.6:c.1760G>C 7:g.55171189G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CHG-100T 2634282 2494678 liver NS NS NS other neoplasm NS NS y COSV51842976 COSM6287773 132547572 c.1217G>A p.R406H Substitution - Missense 38 7:55160192-55160192 + - PATHOGENIC .98594 Confirmed somatic variant 660 NS primary 65 ENSP00000395243.3:p.Arg406His ENST00000454757.6:c.1217G>A 7:g.55160192G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787534 COSM6191454 133204721 c.940T>C p.F314L Substitution - Missense 38 7:55156601-55156601 + - PATHOGENIC .99231 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000415559.1:p.Phe314Leu ENST00000455089.5:c.940T>C 7:g.55156601T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KD826 1005019 922231 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 P-0008285-T01-IM5 2724413 2583234 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876056 2876056 2730571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 56 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LC_S25 1863736 1754627 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 78 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1005000 1005000 922212 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 IGC-11-1112 2662356 2522480 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2812093 2812093 2668556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 59 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LC_C3 1863684 1754575 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 65 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006612-T01-IM5 2722991 2581812 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51843392 COSM6952229 132579237 c.3060C>A p.F1020L Substitution - Missense het 38 7:55202549-55202549 + - .58744 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Phe1020Leu ENST00000454757.6:c.3060C>A 7:g.55202549C>A EGFR ENST00000275493.6 3633 3236 10677523 2751151 2609847 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV105822269 COSM9522392 99399304 c.1006G>C p.V336L Substitution - Missense 38 7:55155946-55155946 + - Confirmed somatic variant 29748005 circulating tumour NS ENSP00000275493.2:p.Val336Leu ENST00000275493.6:c.1006G>C 7:g.55155946G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1040369 1040369 956946 central_nervous_system brain NS NS glioma oligoastrocytoma_Grade_III anaplastic NS n COSV51790148 COSM22555 132554437 c.1895G>A p.R632H Substitution - Missense 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000395243.3:p.Arg632His ENST00000454757.6:c.1895G>A 7:g.55173093G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1040370 1040370 956947 central_nervous_system brain NS NS glioma oligoastrocytoma_Grade_III anaplastic NS n COSV51790148 COSM22555 132554437 c.1895G>A p.R632H Substitution - Missense 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000395243.3:p.Arg632His ENST00000454757.6:c.1895G>A 7:g.55173093G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011333-T01-IM5 2726929 2585750 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51864136 COSM6980296 133209817 c.2890G>T p.D964Y Substitution - Missense het 38 7:55201266-55201266 + - PATHOGENIC .98461 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Asp964Tyr ENST00000455089.5:c.2890G>T 7:g.55201266G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 94271 2807578 2664279 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 24807215 surgery fresh/frozen primary 60 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DA-A3F3-06 2121581 1995817 skin NS NS NS malignant_melanoma NS NS NS y COSV51816429 COSM1698693 133218048 c.1675A>G p.N559D Substitution - Missense 38 7:55165367-55165367 + - NEUTRAL .4812 Confirmed somatic variant 540 NS NS 52 ENSP00000415559.1:p.Asn559Asp ENST00000455089.5:c.1675A>G 7:g.55165367A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812133 2812133 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51829458 COSM51497 132554096 c.2102_2103inv p.E701V Substitution - Missense 38 7:55174774-55174775 + - Confirmed somatic variant 31534501 circulating tumour NS 77 ENSP00000395243.3:p.Glu701Val ENST00000454757.6:c.2102_2103inv 7:g.55174774_55174775inv EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MELA_34952 2760718 2619251 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV51785510 COSM6957413 133202339 c.967G>A p.D323N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 30178487 surgery fresh/frozen metastasis 25 ENSP00000415559.1:p.Asp323Asn ENST00000455089.5:c.967G>A 7:g.55156628G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011544-T01-IM5 2727116 2585937 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51774354 COSM6981709 132611852 c.816G>C p.E272D Substitution - Missense het 38 7:55155891-55155891 + - PATHOGENIC .93673 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Glu272Asp ENST00000454757.6:c.816G>C 7:g.55155891G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51774667 COSM53194 132555352 c.2062C>T p.P688S Substitution - Missense het 38 7:55174734-55174734 + - PATHOGENIC .99806 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000395243.3:p.Pro688Ser ENST00000454757.6:c.2062C>T 7:g.55174734C>T EGFR ENST00000275493.6 3633 3236 1005011 1005011 922223 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2811999 2811999 2668509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed NS 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-55-8096-01 2194781 2063059 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A021-T-S20 2757382 2615995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 57 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1004992 1004992 922204 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007813-T01-IM5 2724038 2582859 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767730 COSM6548312 132554372 c.527G>T p.G176V Substitution - Missense het 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000395243.3:p.Gly176Val ENST00000454757.6:c.527G>T 7:g.55152579G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625912 2625912 2486324 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51840645 COSM6191462 132565778 c.3427A>G p.K1143E Substitution - Missense 38 7:55205546-55205546 + - PATHOGENIC .89998 Confirmed somatic variant 25617745 surgery-fixed NS 66 ENSP00000395243.3:p.Lys1143Glu ENST00000454757.6:c.3427A>G 7:g.55205546A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EX01T 2653305 2513432 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51816692 COSM6503372 132575469 c.2905G>A p.D969N Substitution - Missense 38 7:55201281-55201281 + - PATHOGENIC .99528 Confirmed somatic variant 26647728 NS primary 58.5 ENSP00000395243.3:p.Asp969Asn ENST00000454757.6:c.2905G>A 7:g.55201281G>A EGFR ENST00000275493.6 3633 3236 2876596 2876596 2731111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 64 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KD826 1005019 922231 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1165892 1165892 1078206 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51785733 COSM28575 132575807 c.2515G>A p.E839K Substitution - Missense het 38 7:55192790-55192790 + - PATHOGENIC .9655 Confirmed somatic variant 16407879 surgery - NOS metastasis 70 ENSP00000395243.3:p.Glu839Lys ENST00000454757.6:c.2515G>A 7:g.55192790G>A EGFR ENST00000275493.6 3633 3236 P-0003891-T01-IM5 2720383 2579204 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51822575 COSM6932208 99388446 c.2774C>T p.S925F Substitution - Missense het 38 7:55198789-55198789 + - NEUTRAL .37023 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ser925Phe ENST00000275493.6:c.2774C>T 7:g.55198789C>T EGFR ENST00000275493.6 3633 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787571 COSM6191458 99376554 c.1997T>C p.L666P Substitution - Missense 38 7:55173060-55173060 + - PATHOGENIC .99634 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000275493.2:p.Leu666Pro ENST00000275493.6:c.1997T>C 7:g.55173060T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 7C 2549418 2410873 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51792433 COSM6966446 132577379 c.1627G>A p.G543S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 646 NS primary 66 ENSP00000395243.3:p.Gly543Ser ENST00000454757.6:c.1627G>A 7:g.55165319G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001442-T02-IM5 2719422 2578243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 132565801 c.2146G>T p.D716Y Substitution - Missense het 38 7:55174818-55174818 + - PATHOGENIC .99554 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Asp716Tyr ENST00000454757.6:c.2146G>T 7:g.55174818G>T EGFR ENST00000275493.6 3633 3236 MBC_174 2662675 2522799 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS y COSV51792227 COSM6582372 99381421 c.2659T>A p.L887I Substitution - Missense 38 7:55192799-55192799 + - PATHOGENIC .84827 Confirmed somatic variant 28027327 fresh/frozen - NOS NS ENSP00000275493.2:p.Leu887Ile ENST00000275493.6:c.2659T>A 7:g.55192799T>A EGFR ENST00000275493.6 3633 3236 1595810 1595810 1516607 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS n COSV51789625 COSM13197 99376708 c.2590G>A p.A864T Substitution - Missense hom 38 7:55191839-55191839 + - PATHOGENIC .9615 Confirmed somatic variant 16551849 surgery-fixed NS 55 ENSP00000275493.2:p.Ala864Thr ENST00000275493.6:c.2590G>A 7:g.55191839G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914591 914591 832040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152786 2152786 2021796 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920035 920035 837114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 52 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914588 914588 832037 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489239 1489239 1412397 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 41 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152796 2152796 2021806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1165892 1165892 1078206 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16407879 surgery - NOS metastasis 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 961854 961854 878138 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16467080 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920013 920013 837092 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51802272 COSM13425 133221191 c.2170G>A p.V724M Substitution - Missense het 38 7:55181314-55181314 + - PATHOGENIC .98024 Confirmed somatic variant 15623594 surgery fresh/frozen NS 62 ENSP00000415559.1:p.Val724Met ENST00000455089.5:c.2170G>A 7:g.55181314G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MSU4-c 2809981 2666643 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV99291971 COSM9172239 132574422 c.1685T>C p.V562A Substitution - Missense 38 7:55165377-55165377 + - PATHOGENIC .99812 Confirmed somatic variant 26336987 surgery fresh/frozen primary 76 ENSP00000395243.3:p.Val562Ala ENST00000454757.6:c.1685T>C 7:g.55165377T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1322232 1322232 1233119 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51806057 COSM41603 132580496 c.1999T>C p.F667L Substitution - Missense 38 7:55173993-55173993 + - PATHOGENIC .92149 Confirmed somatic variant 19844187 surgery-fixed primary 43 ENSP00000395243.3:p.Phe667Leu ENST00000454757.6:c.1999T>C 7:g.55173993T>C EGFR ENST00000275493.6 3633 3236 P-0003108-T01-IM5 2719604 2578425 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51866279 COSM6926300 99378313 c.665G>A p.R222H Substitution - Missense het 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000275493.2:p.Arg222His ENST00000275493.6:c.665G>A 7:g.55152582G>A EGFR ENST00000275493.6 3633 3236 1194726 1194726 1106621 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-CA-5254-01 1651181 1565968 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV99289896 COSM7552012 133249775 c.2881G>A p.D961N Substitution - Missense 38 7:55201257-55201257 + - PATHOGENIC .98884 Confirmed somatic variant 376 NS NS 42 ENSP00000415559.1:p.Asp961Asn ENST00000455089.5:c.2881G>A 7:g.55201257G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LICA-CN-HCC055T 2634102 2494498 liver NS NS NS other neoplasm NS NS y COSV51829036 COSM5823994 132570248 c.866G>C p.R289P Substitution - Missense 38 7:55155941-55155941 + - PATHOGENIC .84442 Confirmed somatic variant 660 NS primary 65 ENSP00000395243.3:p.Arg289Pro ENST00000454757.6:c.866G>C 7:g.55155941G>C EGFR ENST00000275493.6 3633 3236 2777771 2777771 2635906 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSM7408755 178389259 c.? p.H584Q Substitution - Missense + - Confirmed somatic variant 30041611 surgery-fixed NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460138 1460138 1384015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206766 1206766 1118644 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005034-T01-IM5 2721439 2580260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001514-T01-IM3 2717445 2576266 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982871 982871 898590 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T1748 2658268 2518427 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51796395 COSM6652238 132598179 c.1109C>T p.T370M Substitution - Missense 38 7:55157699-55157699 + - PATHOGENIC .97374 Confirmed somatic variant 27149842 NS NS 85.08 ENSP00000395243.3:p.Thr370Met ENST00000454757.6:c.1109C>T 7:g.55157699C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007897-T01-IM5 2724108 2582929 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010754-T01-IM5 2787068 2644491 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51805749 COSM6976991 132548558 c.2509G>A p.A837T Substitution - Missense 38 7:55192784-55192784 + - PATHOGENIC .95513 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000395243.3:p.Ala837Thr ENST00000454757.6:c.2509G>A 7:g.55192784G>A EGFR ENST00000275493.6 3633 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51841863 COSM6913649 99377584 c.3415C>T p.L1139F Substitution - Missense het 38 7:55205399-55205399 + - PATHOGENIC .96614 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu1139Phe ENST00000275493.6:c.3415C>T 7:g.55205399C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003679-T01-IM5 2720169 2578990 stomach gastroesophageal_junction NS NS carcinoma adenocarcinoma NS NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767280 COSM133183 99392721 c.2142G>C p.K714N Substitution - Missense 38 7:55174001-55174001 + - PATHOGENIC .89357 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000275493.2:p.Lys714Asn ENST00000275493.6:c.2142G>C 7:g.55174001G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876608 2876608 2731123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206766 1206766 1118644 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005034-T01-IM5 2721439 2580260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-28-1752-01 2178270 2046568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 42 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982787 982787 898506 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EOSRC-IN-2785 2902114 2756352 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV105864249 COSM9977627 133249693 c.2276A>T p.E759V Substitution - Missense 38 7:55181420-55181420 + - PATHOGENIC .97936 Confirmed somatic variant 33262464 surgery - NOS NS 55 ENSP00000415559.1:p.Glu759Val ENST00000455089.5:c.2276A>T 7:g.55181420A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876610 2876610 2731125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0174-01 1910190 1798481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 fresh/frozen - NOS primary 54 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 EX01T 2653305 2513432 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51816692 COSM6503372 99407654 c.3040G>A p.D1014N Substitution - Missense 38 7:55201281-55201281 + - PATHOGENIC .99528 Confirmed somatic variant 26647728 NS primary 58.5 ENSP00000275493.2:p.Asp1014Asn ENST00000275493.6:c.3040G>A 7:g.55201281G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MSU4-c 2809981 2666643 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV99291971 COSM9172239 133232801 c.1685T>C p.V562A Substitution - Missense 38 7:55165377-55165377 + - PATHOGENIC .99812 Confirmed somatic variant 26336987 surgery fresh/frozen primary 76 ENSP00000415559.1:p.Val562Ala ENST00000455089.5:c.1685T>C 7:g.55165377T>C EGFR ENST00000275493.6 3633 3236 2901988 2901988 2756229 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM5010368 178378709 c.? p.C797S Substitution - Missense + Yes Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Cys797Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005337-T01-IM5 2721741 2580562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BR-6452-01 2197940 2066218 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51804028 COSM3881820 133215144 c.1372G>T p.G458C Substitution - Missense 38 7:55161507-55161507 + - NEUTRAL .38516 Confirmed somatic variant 541 NS NS 78 ENSP00000415559.1:p.Gly458Cys ENST00000455089.5:c.1372G>T 7:g.55161507G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EX01T 2653305 2513432 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS primary 58.5 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007037-T01-IM5 2830039 2685854 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843415 COSM6955777 133240031 c.1104C>A p.N368K Substitution - Missense 38 7:55157694-55157694 + - PATHOGENIC .97853 Confirmed somatic variant 30205045 surgery-fixed metastasis 57 ENSP00000415559.1:p.Asn368Lys ENST00000455089.5:c.1104C>A 7:g.55157694C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AM-5821-01 1651151 1565938 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV99291226 COSM7552389 132573051 c.989C>T p.A330V Substitution - Missense 38 7:55156650-55156650 + - PATHOGENIC .98971 Confirmed somatic variant 376 NS NS 68 ENSP00000395243.3:p.Ala330Val ENST00000454757.6:c.989C>T 7:g.55156650C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006561-T02-IM5 2722939 2581760 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1322267 1322267 1233154 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 84 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1322273 1322273 1233160 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 43 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-L9-A50W-01 2263346 2130330 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS primary 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-14-1034-02 2120293 1994529 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51775191 COSM1451530 133205080 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 329 NS NS 60 ENSP00000415559.1:p.Gly63Arg ENST00000455089.5:c.187G>A 7:g.55142384G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008577-T02-IM5 2724678 2583499 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982872 982872 898591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206735 1206735 1118613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_C24 1863705 1754596 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471539 1471539 1395278 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1165893 1165893 1078207 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51785733 COSM28575 99408096 c.2650G>A p.E884K Substitution - Missense het 38 7:55192790-55192790 + - PATHOGENIC .9655 Confirmed somatic variant 16407879 cerebrospinal fluid metastasis 70 ENSP00000275493.2:p.Glu884Lys ENST00000275493.6:c.2650G>A 7:g.55192790G>A EGFR ENST00000275493.6 3633 3236 SK-MEL-28 1998476 1883548 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm hairy_cell_leukaemia NS NS y COSV51778029 COSM6268 99381060 c.2257C>T p.P753S Substitution - Missense hom 38 7:55174794-55174794 + - PATHOGENIC .98527 Confirmed somatic variant 23856246 cell-line primary ENSP00000275493.2:p.Pro753Ser ENST00000275493.6:c.2257C>T 7:g.55174794C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001442-T02-IM5 2719422 2578243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001259 1001259 918482 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471542 1471542 1395281 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004714-T01-IM5 2721118 2579939 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A014-T-S55 2758141 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-OL-A5RZ-01 2187696 2055974 breast NS NS NS carcinoma NS NS NS y COSV99288978 COSM7695792 133223438 c.289G>C p.E97Q Substitution - Missense 38 7:55143353-55143353 + - PATHOGENIC .94007 Confirmed somatic variant 414 NS NS 57 ENSP00000415559.1:p.Glu97Gln ENST00000455089.5:c.289G>C 7:g.55143353G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 128 2748100 2606803 stomach NS NS NS carcinoma NS NS NS y COSV99288147 COSM8566415 133269781 c.2696A>G p.Y899C Substitution - Missense 38 7:55198846-55198846 + - PATHOGENIC .98856 Confirmed somatic variant 683 NS primary ENSP00000415559.1:p.Tyr899Cys ENST00000455089.5:c.2696A>G 7:g.55198846A>G EGFR ENST00000275493.6 3633 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801757 COSM3923815 99432423 c.2872C>T p.R958C Substitution - Missense 38 7:55200339-55200339 + - PATHOGENIC .97155 Confirmed somatic variant 540 NS NS 68 ENSP00000275493.2:p.Arg958Cys ENST00000275493.6:c.2872C>T 7:g.55200339C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812133 2812133 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV99289025 COSM9179905 132554109 c.2116A>G p.T706A Substitution - Missense 38 7:55174788-55174788 + - PATHOGENIC .9946 Confirmed somatic variant 31534501 circulating tumour NS 77 ENSP00000395243.3:p.Thr706Ala ENST00000454757.6:c.2116A>G 7:g.55174788A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 B103-S1 2732514 2591270 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV104576423 COSM9498532 132555570 c.1566G>T p.M522I Substitution - Missense 38 7:55163802-55163802 + - PATHOGENIC .93931 Confirmed somatic variant 29244145 surgery fresh/frozen primary 74.3 ENSP00000395243.3:p.Met522Ile ENST00000454757.6:c.1566G>T 7:g.55163802G>T EGFR ENST00000275493.6 3633 3236 2777771 2777771 2635906 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSM7408750 178389240 c.? p.A237V Substitution - Missense + - Confirmed somatic variant 30041611 surgery-fixed NS ENSP00000275493.2:p.Ala237Val EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007100-T01-IM5 2723473 2582294 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51776957 COSM6955986 133249041 c.2986A>G p.T996A Substitution - Missense het 38 7:55201741-55201741 + - PATHOGENIC .92147 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr996Ala ENST00000455089.5:c.2986A>G 7:g.55201741A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105111127 COSM9869918 132619110 c.2239C>G p.L747V Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .95352 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000395243.3:p.Leu747Val ENST00000454757.6:c.2239C>G 7:g.55181383C>G EGFR ENST00000275493.6 3633 3236 P-0005337-T01-IM5 2721741 2580562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CTS21 2393074 2255905 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0008577-T01-IM5 2724677 2583498 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A001-T-S01 2757354 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489261 1489261 1412419 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 55 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A017-T-S11 2757376 2615994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 56 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1179549 1179549 1091511 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0004328-T02-IM5 2720735 2579556 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1165893 1165893 1078207 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16407879 cerebrospinal fluid metastasis 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 PM02M 2653318 2513445 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS metastasis 75.8 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812133 2812133 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51829458 COSM51497 133209395 c.2102_2103inv p.E701V Substitution - Missense 38 7:55174774-55174775 + - Confirmed somatic variant 31534501 circulating tumour NS 77 ENSP00000415559.1:p.Glu701Val ENST00000455089.5:c.2102_2103inv 7:g.55174774_55174775inv EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2014_Lung_sq_82_T 2744953 2603656 lung NS NS NS carcinoma NS NS NS y COSV51818682 COSM7238574 132598279 c.2965C>A p.L989I Substitution - Missense 38 7:55201341-55201341 + - PATHOGENIC .99175 Confirmed somatic variant 583 NS primary 62 ENSP00000395243.3:p.Leu989Ile ENST00000454757.6:c.2965C>A 7:g.55201341C>A EGFR ENST00000275493.6 3633 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801732 COSM3923812 99432390 c.1091C>T p.S364F Substitution - Missense 38 7:55156617-55156617 + - NEUTRAL .433 Confirmed somatic variant 540 NS NS 68 ENSP00000275493.2:p.Ser364Phe ENST00000275493.6:c.1091C>T 7:g.55156617C>T EGFR ENST00000275493.6 3633 3236 TCGA-DA-A3F3-06 2121581 1995817 skin NS NS NS malignant_melanoma NS NS NS y COSV51816429 COSM1698693 99390361 c.1810A>G p.N604D Substitution - Missense 38 7:55165367-55165367 + - NEUTRAL .4812 Confirmed somatic variant 540 NS NS 52 ENSP00000275493.2:p.Asn604Asp ENST00000275493.6:c.1810A>G 7:g.55165367A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002783-T01-IM3 2719014 2577835 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004983 1004983 922195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103792 1103792 1018044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152772 2152772 2021782 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982862 982862 898581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 16724 1423709 1333737 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005264-T01-IM5 2721663 2580484 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 NS metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043303 1043303 959644 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17186532 surgery-fixed NS 57 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A028-T-S21 2757396 2615998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003573-T02-IM5 2720059 2578880 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787534 COSM6191454 99376533 c.1075T>C p.F359L Substitution - Missense 38 7:55156601-55156601 + - PATHOGENIC .99231 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000275493.2:p.Phe359Leu ENST00000275493.6:c.1075T>C 7:g.55156601T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008664-T01-IM5 2724728 2583549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A102-T-S29 2757413 2616002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0002649-T01-IM3 2829504 2685319 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51794834 COSM5575633 99386191 c.2873G>A p.R958H Substitution - Missense 38 7:55200340-55200340 + - PATHOGENIC .99504 Confirmed somatic variant 30205045 surgery-fixed primary 53 ENSP00000275493.2:p.Arg958His ENST00000275493.6:c.2873G>A 7:g.55200340G>A EGFR ENST00000275493.6 3633 3236 P-0005337-T01-IM5 2721741 2580562 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005076-T01-IM5 2721479 2580300 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51836384 COSM6940904 133235082 c.2071G>A p.E691K Substitution - Missense het 38 7:55174743-55174743 + - PATHOGENIC .99879 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Glu691Lys ENST00000455089.5:c.2071G>A 7:g.55174743G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 s_DS_scb_02_tumour 2861572 2716810 urinary_tract bladder NS NS carcinoma small_cell_carcinoma NS NS n COSV105109947 COSM9575249 132567381 c.538G>A p.G180S Substitution - Missense 38 7:55152590-55152590 + - PATHOGENIC .99676 Confirmed somatic variant 29180607 surgery-fixed NS 68 ENSP00000395243.3:p.Gly180Ser ENST00000454757.6:c.538G>A 7:g.55152590G>A EGFR ENST00000275493.6 3633 3236 1468623 1468623 1392374 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1170508 1170508 1082642 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 19117057 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 7C 2549418 2410873 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51792433 COSM6966446 133237386 c.1627G>A p.G543S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 646 NS primary 66 ENSP00000415559.1:p.Gly543Ser ENST00000455089.5:c.1627G>A 7:g.55165319G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-0750 2107989 1985850 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51807036 COSM2151966 99389686 c.1787C>G p.P596R Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99615 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Pro596Arg ENST00000275493.6:c.1787C>G 7:g.55165344C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460138 1460138 1384015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 133204348 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000415559.1:p.Pro803Leu ENST00000455089.5:c.2408C>T 7:g.55191792C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004706-T01-IM5 2721110 2579931 eye uveal_tract NS NS malignant_melanoma NS NS NS n COSV51862598 COSM6938266 132547606 c.1889G>A p.R630Q Substitution - Missense het 38 7:55173087-55173087 + - PATHOGENIC .98305 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Arg630Gln ENST00000454757.6:c.1889G>A 7:g.55173087G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S06-38853-TP 2366573 2229456 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51796296 COSM4992967 132593200 c.1505G>A p.R502K Substitution - Missense het 38 7:55163741-55163741 + - PATHOGENIC .992 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000395243.3:p.Arg502Lys ENST00000454757.6:c.1505G>A 7:g.55163741G>A EGFR ENST00000275493.6 3633 3236 134 897200 814823 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A062-T-S11 2757397 2615999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876661 2876661 2731176 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152790 2152790 2021800 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206715 1206715 1118593 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001914-T01-IM3 2718230 2577051 central_nervous_system brain NS NS glioma astrocytoma NS NS n COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense het 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-3650-01 2120284 1994520 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51845825 COSM3412188 132557485 c.1145G>T p.R382L Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .99702 Confirmed somatic variant 329 NS NS 46 ENSP00000395243.3:p.Arg382Leu ENST00000454757.6:c.1145G>T 7:g.55157735G>T EGFR ENST00000275493.6 3633 3236 P-0007846-T01-IM5 2724058 2582879 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982853 982853 898572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458690 1458690 1382665 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CTS175 2393056 2255887 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 56 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2811978 2811978 2668502 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed NS 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 S07-39193-TP 2366575 2229458 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51792018 COSM4992972 99378183 c.3134C>T p.S1045F Substitution - Missense het 38 7:55201754-55201754 + - PATHOGENIC .97067 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000275493.2:p.Ser1045Phe ENST00000275493.6:c.3134C>T 7:g.55201754C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787557 COSM6191456 133204732 c.1202C>T p.T401I Substitution - Missense 38 7:55160177-55160177 + - NEUTRAL .13103 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000415559.1:p.Thr401Ile ENST00000455089.5:c.1202C>T 7:g.55160177C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1040384 1040384 956961 central_nervous_system brain NS NS glioma oligoastrocytoma NS NS n COSV51790148 COSM22555 132554437 c.1895G>A p.R632H Substitution - Missense 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000395243.3:p.Arg632His ENST00000454757.6:c.1895G>A 7:g.55173093G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SJERG020309_D1 2565683 2427077 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51802051 COSM5986345 132584532 c.1858G>A p.G620S Substitution - Missense 38 7:55173056-55173056 + - PATHOGENIC .98464 Confirmed somatic variant 27776115 blood-bone marrow primary 17.5 ENSP00000395243.3:p.Gly620Ser ENST00000454757.6:c.1858G>A 7:g.55173056G>A EGFR ENST00000275493.6 3633 3236 1460138 1460138 1384015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 99376120 c.2543C>T p.P848L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000275493.2:p.Pro848Leu ENST00000275493.6:c.2543C>T 7:g.55191792C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2842026 2842026 2697575 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 133216074 c.1339A>C p.S447R Substitution - Missense 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000415559.1:p.Ser447Arg ENST00000455089.5:c.1339A>C 7:g.55160314A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-28-1757-01 2178083 2046381 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 71 ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EXTERN_MELA_20140924_001 2839320 2695086 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51781835 COSM174732 133207258 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28467829 cell-line metastasis ENSP00000415559.1:p.Glu114Lys ENST00000455089.5:c.340G>A 7:g.55143404G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2014_Lung_sq_82_T 2744953 2603656 lung NS NS NS carcinoma NS NS NS y COSV51818649 COSM7238502 132598259 c.1227G>T p.K409N Substitution - Missense 38 7:55160202-55160202 + - PATHOGENIC .92978 Confirmed somatic variant 583 NS primary 62 ENSP00000395243.3:p.Lys409Asn ENST00000454757.6:c.1227G>T 7:g.55160202G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 166 897193 814816 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920017 920017 837096 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982875 982875 898594 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-86-8668-01 2194764 2063042 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 61 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1790521 1790521 1693500 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 402 898388 816000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458699 1458699 1382674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982857 982857 898576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471541 1471541 1395280 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767280 COSM133183 133220067 c.2007G>C p.K669N Substitution - Missense 38 7:55174001-55174001 + - PATHOGENIC .89357 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000415559.1:p.Lys669Asn ENST00000455089.5:c.2007G>C 7:g.55174001G>C EGFR ENST00000275493.6 3633 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787557 COSM6191456 99376546 c.1337C>T p.T446I Substitution - Missense 38 7:55160177-55160177 + - NEUTRAL .13103 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000275493.2:p.Thr446Ile ENST00000275493.6:c.1337C>T 7:g.55160177C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BA-6872-01 2193616 2061894 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99294544 COSM8387616 132566632 c.436G>A p.D146N Substitution - Missense 38 7:55151305-55151305 + - PATHOGENIC .93234 Confirmed somatic variant 627 NS NS 47 ENSP00000395243.3:p.Asp146Asn ENST00000454757.6:c.436G>A 7:g.55151305G>A EGFR ENST00000275493.6 3633 3236 TCGA-BH-A18U-01 1899961 1788645 breast NS NS NS carcinoma NS NS NS y COSV99294745 COSM7670588 99415591 c.769G>A p.E257K Substitution - Missense 38 7:55154032-55154032 + - PATHOGENIC .97243 Confirmed somatic variant 414 fresh/frozen - NOS primary 72 ENSP00000275493.2:p.Glu257Lys ENST00000275493.6:c.769G>A 7:g.55154032G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2697837 2697837 2556741 breast NS NS NS carcinoma NS NS NS n COSV51811430 COSM6906106 132604769 c.1130A>G p.N377S Substitution - Missense 38 7:55157720-55157720 + - PATHOGENIC .99784 Confirmed somatic variant 29349598 NS NS ENSP00000395243.3:p.Asn377Ser ENST00000454757.6:c.1130A>G 7:g.55157720A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T1849 2658271 2518430 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51794659 COSM6652247 133226550 c.1585C>T p.R529W Substitution - Missense 38 7:55163821-55163821 + - PATHOGENIC .97962 Confirmed somatic variant 27149842 NS NS 79.25 ENSP00000415559.1:p.Arg529Trp ENST00000455089.5:c.1585C>T 7:g.55163821C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007037-T01-IM5 2723412 2582233 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843415 COSM6955777 133240031 c.1104C>A p.N368K Substitution - Missense het 38 7:55157694-55157694 + - PATHOGENIC .97853 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Asn368Lys ENST00000455089.5:c.1104C>A 7:g.55157694C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876608 2876608 2731123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 133216269 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2254T>A 7:g.55181398T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876610 2876610 2731125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 133216269 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812086 2812086 2668553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51823614 COSM4170219 132547383 c.2120C>T p.S707F Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98332 Confirmed somatic variant 31534501 pleural effusion NS 76 ENSP00000395243.3:p.Ser707Phe ENST00000454757.6:c.2120C>T 7:g.55174792C>T EGFR ENST00000275493.6 3633 3236 2777771 2777771 2635906 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSM7408757 178389235 c.? p.L1139F Substitution - Missense + - Confirmed somatic variant 30041611 surgery-fixed NS ENSP00000275493.2:p.Leu1139Phe EGFR ENST00000275493.6 3633 3236 TCGA-BP-4354-01 2120471 1994707 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51815927 COSM24971 99392587 c.2513T>C p.L838P Substitution - Missense 38 7:55191762-55191762 + - PATHOGENIC .97813 Confirmed somatic variant 416 NS NS 40 ENSP00000275493.2:p.Leu838Pro ENST00000275493.6:c.2513T>C 7:g.55191762T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876608 2876608 2731123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 133219834 c.2239C>T p.L747F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour NS ENSP00000415559.1:p.Leu747Phe ENST00000455089.5:c.2239C>T 7:g.55181383C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001506-T01-IM3 2717427 2576248 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51844512 COSM6917413 132573839 c.2700G>A p.M900I Substitution - Missense het 38 7:55198850-55198850 + - PATHOGENIC .99081 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Met900Ile ENST00000454757.6:c.2700G>A 7:g.55198850G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1044285 1044285 960626 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004993 1004993 922205 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471549 1471549 1395288 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005003 1005003 922215 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001328-T01-IM3 2717084 2575905 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920106 920106 837185 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery-fixed NS 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812000 2812000 2668509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-97-A4M1-01 2385678 2248510 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS primary 52 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471545 1471545 1395284 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2246145 2246145 2113419 lung left_lower_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25176975 surgery - NOS primary 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471535 1471535 1395274 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876608 2876608 2731123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832145 COSM6493936 133233446 c.2254T>G p.C752G Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95801 Confirmed somatic variant 29506987 circulating tumour NS ENSP00000415559.1:p.Cys752Gly ENST00000455089.5:c.2254T>G 7:g.55181398T>G EGFR ENST00000275493.6 3633 3236 PD42099a 2894830 2749318 skin head_neck NS NS malignant_melanoma lentigo_maligna NS NS y COSV105110419 COSM9894626 99415960 c.2974C>T p.P992S Substitution - Missense 38 7:55201215-55201215 + - PATHOGENIC .99346 Confirmed somatic variant 33024263 surgery-fixed metastasis 60 ENSP00000275493.2:p.Pro992Ser ENST00000275493.6:c.2974C>T 7:g.55201215C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DU-7006-01 2194244 2062522 central_nervous_system brain NS NS glioma NS NS NS y COSV51800797 COSM3412178 133213607 c.620G>C p.R207P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 545 NS NS 60 ENSP00000415559.1:p.Arg207Pro ENST00000455089.5:c.620G>C 7:g.55154018G>C EGFR ENST00000275493.6 3633 3236 Br124X 1313013 1223922 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 xenograft primary 44 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 P-0006150-T01-IM5 2722528 2581349 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51857876 COSM6948549 99390941 c.3352G>T p.A1118S Substitution - Missense het 38 7:55205336-55205336 + - NEUTRAL .12775 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Ala1118Ser ENST00000275493.6:c.3352G>T 7:g.55205336G>T EGFR ENST00000275493.6 3633 3236 1460138 1460138 1384015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790305 COSM13194 99378747 c.2540C>T p.T847I Substitution - Missense 38 7:55191789-55191789 + - PATHOGENIC .95119 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000275493.2:p.Thr847Ile ENST00000275493.6:c.2540C>T 7:g.55191789C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876611 2876611 2731126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 132563558 c.2239C>T p.L747F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000395243.3:p.Leu747Phe ENST00000454757.6:c.2239C>T 7:g.55181383C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876595 2876595 2731110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 132560202 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006714-T01-IM5 2723094 2581915 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51834490 COSM6953161 132592282 c.2494C>G p.P832A Substitution - Missense het 38 7:55192769-55192769 + - PATHOGENIC .95807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Pro832Ala ENST00000454757.6:c.2494C>G 7:g.55192769C>G EGFR ENST00000275493.6 3633 3236 MSU4-c 2809981 2666643 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV99291971 COSM9172239 99406449 c.1820T>C p.V607A Substitution - Missense 38 7:55165377-55165377 + - PATHOGENIC .99812 Confirmed somatic variant 26336987 surgery fresh/frozen primary 76 ENSP00000275493.2:p.Val607Ala ENST00000275493.6:c.1820T>C 7:g.55165377T>C EGFR ENST00000275493.6 3633 3236 1001261 1001261 918484 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 982789 982789 898508 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-RS 2060455 1940662 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma Richter_transformation NS y COSV51773206 COSM28603 133217070 c.2158G>A p.V720M Substitution - Missense 38 7:55181302-55181302 + - PATHOGENIC .97963 Confirmed somatic variant 24127483 blood-bone marrow primary 69 ENSP00000415559.1:p.Val720Met ENST00000455089.5:c.2158G>A 7:g.55181302G>A EGFR ENST00000275493.6 3633 3236 2812086 2812086 2668553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51823614 COSM4170219 99373800 c.2255C>T p.S752F Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98332 Confirmed somatic variant 31534501 pleural effusion NS 76 ENSP00000275493.2:p.Ser752Phe ENST00000275493.6:c.2255C>T 7:g.55174792C>T EGFR ENST00000275493.6 3633 3236 1322232 1322232 1233119 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51806057 COSM41603 99415829 c.2134T>C p.F712L Substitution - Missense 38 7:55173993-55173993 + - PATHOGENIC .92149 Confirmed somatic variant 19844187 surgery-fixed primary 43 ENSP00000275493.2:p.Phe712Leu ENST00000275493.6:c.2134T>C 7:g.55173993T>C EGFR ENST00000275493.6 3633 3236 TCGA-HT-8110-01 2194393 2062671 central_nervous_system brain NS NS glioma NS NS NS y COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 545 NS NS 57 ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 P-0002489-T01-IM3 2718761 2577582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005076-T01-IM5 2721479 2580300 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51785733 COSM28575 133235090 c.2515G>A p.E839K Substitution - Missense het 38 7:55192790-55192790 + - PATHOGENIC .9655 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Glu839Lys ENST00000455089.5:c.2515G>A 7:g.55192790G>A EGFR ENST00000275493.6 3633 3236 P-0010610-T01-IM5 2726309 2585130 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51839766 COSM6975560 99381474 c.1864C>G p.P622A Substitution - Missense het 38 7:55165421-55165421 + - NEUTRAL .24318 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Pro622Ala ENST00000275493.6:c.1864C>G 7:g.55165421C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005585-T01-IM5 2721978 2580799 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51837327 COSM6944624 132547612 c.2856C>G p.F952L Substitution - Missense het 38 7:55201232-55201232 + - NEUTRAL .42217 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Phe952Leu ENST00000454757.6:c.2856C>G 7:g.55201232C>G EGFR ENST00000275493.6 3633 3236 KD826 1005019 922231 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 P-0001649-T01-IM3 2717717 2576538 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS n COSV51792269 COSM6918047 99413285 c.2443C>T p.L815F Substitution - Missense het 38 7:55181452-55181452 + - PATHOGENIC .96277 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu815Phe ENST00000275493.6:c.2443C>T 7:g.55181452C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AA-3966-01 1651077 1565864 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51801471 COSM53105 132553118 c.2357G>A p.R786H Substitution - Missense 38 7:55191741-55191741 + - PATHOGENIC .96289 Confirmed somatic variant 22810696 376 NS NS 89 ENSP00000395243.3:p.Arg786His ENST00000454757.6:c.2357G>A 7:g.55191741G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2492703 2492703 2355318 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 133227476 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000415559.1:p.His47Tyr ENST00000455089.5:c.139C>T 7:g.55142336C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DU-7006-01 2194244 2062522 central_nervous_system brain NS NS glioma NS NS NS y COSV51800797 COSM3412178 132557507 c.620G>C p.R207P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 545 NS NS 60 ENSP00000395243.3:p.Arg207Pro ENST00000454757.6:c.620G>C 7:g.55154018G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003891-T01-IM5 2720383 2579204 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51822575 COSM6932208 132560387 c.2639C>T p.S880F Substitution - Missense het 38 7:55198789-55198789 + - NEUTRAL .37023 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ser880Phe ENST00000454757.6:c.2639C>T 7:g.55198789C>T EGFR ENST00000275493.6 3633 3236 2777771 2777771 2635906 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSM7408758 178389245 c.? p.V1200I Substitution - Missense + - Confirmed somatic variant 30041611 surgery-fixed NS EGFR_ENST00000454757 ENST00000454757.6 3498 3236 019T 2067099 1946896 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51840438 COSM1727959 132565624 c.374A>G p.Y125C Substitution - Missense 38 7:55143438-55143438 + - PATHOGENIC .99088 Confirmed somatic variant 23788652 surgery - NOS primary ENSP00000395243.3:p.Tyr125Cys ENST00000454757.6:c.374A>G 7:g.55143438A>G EGFR ENST00000275493.6 3633 3236 TCGA-OL-A5RZ-01 2187696 2055974 breast NS NS NS carcinoma NS NS NS y COSV99288978 COSM7695792 99397802 c.289G>C p.E97Q Substitution - Missense 38 7:55143353-55143353 + - PATHOGENIC .94007 Confirmed somatic variant 414 NS NS 57 ENSP00000275493.2:p.Glu97Gln ENST00000275493.6:c.289G>C 7:g.55143353G>C EGFR ENST00000275493.6 3633 3236 P-0012262-T01-IM5 2727369 2586190 salivary_gland major NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51794983 COSM1451619 99431548 c.3287C>T p.S1096F Substitution - Missense het 38 7:55205271-55205271 + - NEUTRAL .09807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ser1096Phe ENST00000275493.6:c.3287C>T 7:g.55205271C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EX01T 2653305 2513432 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51816692 COSM6503372 133234498 c.2905G>A p.D969N Substitution - Missense 38 7:55201281-55201281 + - PATHOGENIC .99528 Confirmed somatic variant 26647728 NS primary 58.5 ENSP00000415559.1:p.Asp969Asn ENST00000455089.5:c.2905G>A 7:g.55201281G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-28-1752-01 2178270 2046568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 42 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010610-T01-IM5 2726309 2585130 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51839766 COSM6975560 133209801 c.1729C>G p.P577A Substitution - Missense het 38 7:55165421-55165421 + - NEUTRAL .24318 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Pro577Ala ENST00000455089.5:c.1729C>G 7:g.55165421C>G EGFR ENST00000275493.6 3633 3236 TCGA-28-1752-01 2178270 2046568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 42 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 HCC827 2776313 2634449 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS y COSV51789379 COSM4362784 132565267 c.2102A>C p.E701A Substitution - Missense 38 7:55174774-55174774 + - PATHOGENIC .97548 Confirmed somatic variant 29681454 NS NS 38 ENSP00000395243.3:p.Glu701Ala ENST00000454757.6:c.2102A>C 7:g.55174774A>C EGFR ENST00000275493.6 3633 3236 1140654 1140654 1053102 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26138 178387145 c.? p.L692P Substitution - Missense + - Confirmed somatic variant 19238633 surgery-fixed metastasis 68 EGFR ENST00000275493.6 3633 3236 1468618 1468618 1392369 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM53173 178388741 c.? p.G779V Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-HT-8110-01 2194393 2062671 central_nervous_system brain NS NS glioma NS NS NS y COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 545 NS NS 57 ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Br124X 1313013 1223922 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 xenograft primary 44 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0142-01 2120247 1994483 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 81 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2876608 2876608 2731123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 99392449 c.2374C>T p.L792F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour NS ENSP00000275493.2:p.Leu792Phe ENST00000275493.6:c.2374C>T 7:g.55181383C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T1849 2658271 2518430 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51794620 COSM6652251 133255502 c.46G>A p.A16T Substitution - Missense 38 7:55019323-55019323 + - NEUTRAL .21777 Confirmed somatic variant 27149842 NS NS 79.25 ENSP00000415559.1:p.Ala16Thr ENST00000455089.5:c.46G>A 7:g.55019323G>A EGFR ENST00000275493.6 3633 3236 P-0005076-T01-IM5 2721479 2580300 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51836384 COSM6940904 99408090 c.2206G>A p.E736K Substitution - Missense het 38 7:55174743-55174743 + - PATHOGENIC .99879 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Glu736Lys ENST00000275493.6:c.2206G>A 7:g.55174743G>A EGFR ENST00000275493.6 3633 3236 1002741 1002741 919958 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense het + - Confirmed somatic variant 16115929 surgery-fixed NS 67 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 2076197 2076197 1955010 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 24396447 bronchoalveolar lavage fluid NS 78 ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 TCGA-DK-AA6L-01 2385744 2248576 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51816076 COSM53287 99400367 c.2131G>A p.E711K Substitution - Missense 38 7:55173990-55173990 + - PATHOGENIC .97511 Confirmed somatic variant 413 NS primary 48 ENSP00000275493.2:p.Glu711Lys ENST00000275493.6:c.2131G>A 7:g.55173990G>A EGFR ENST00000275493.6 3633 3236 TCGA-14-1455-01 2178074 2046372 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 99388542 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 NS NS 61 ENSP00000275493.2:p.Thr363Ile ENST00000275493.6:c.1088C>T 7:g.55156614C>T EGFR ENST00000275493.6 3633 3236 T1849 2658271 2518430 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51794659 COSM6652247 99401191 c.1720C>T p.R574W Substitution - Missense 38 7:55163821-55163821 + - PATHOGENIC .97962 Confirmed somatic variant 27149842 NS NS 79.25 ENSP00000275493.2:p.Arg574Trp ENST00000275493.6:c.1720C>T 7:g.55163821C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1595810 1595810 1516607 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS n COSV51789625 COSM13197 132549922 c.2455G>A p.A819T Substitution - Missense hom 38 7:55191839-55191839 + - PATHOGENIC .9615 Confirmed somatic variant 16551849 surgery-fixed NS 55 ENSP00000395243.3:p.Ala819Thr ENST00000454757.6:c.2455G>A 7:g.55191839G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194726 1194726 1106621 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 B105-0-Tumor 2185749 2054046 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51776529 COSM1755314 133255255 c.1745G>A p.G582E Substitution - Missense 38 7:55165437-55165437 + - PATHOGENIC .99581 Confirmed somatic variant 581 NS NS ENSP00000415559.1:p.Gly582Glu ENST00000455089.5:c.1745G>A 7:g.55165437G>A EGFR ENST00000275493.6 3633 3236 94271 2807578 2664279 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 24807215 surgery fresh/frozen primary 60 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 TCGA-76-6282-01 2120389 1994625 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51810174 COSM3412190 99382170 c.1712G>C p.C571S Substitution - Missense 38 7:55163813-55163813 + - PATHOGENIC .99637 Confirmed somatic variant 329 NS NS 63 ENSP00000275493.2:p.Cys571Ser ENST00000275493.6:c.1712G>C 7:g.55163813G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T521 2658729 2518888 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51769243 COSM6652288 133254885 c.2167A>G p.S723G Substitution - Missense 38 7:55181311-55181311 + - PATHOGENIC .97311 Confirmed somatic variant 27149842 NS NS 62.83 ENSP00000415559.1:p.Ser723Gly ENST00000455089.5:c.2167A>G 7:g.55181311A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811952 2811952 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 31534501 pleural effusion NS 69 ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV104369003 COSM9233187 132578308 c.2161A>T p.M721L Substitution - Missense het 38 7:55181305-55181305 + - PATHOGENIC .98406 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000395243.3:p.Met721Leu ENST00000454757.6:c.2161A>T 7:g.55181305A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876610 2876610 2731125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 133206317 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000415559.1:p.Arg731His ENST00000455089.5:c.2192G>A 7:g.55181336G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1468096 1468096 1391942 peritoneum NS NS NS mesothelioma NS NS NS n COSV51771943 COSM22953 133226746 c.2266T>C p.Y756H Substitution - Missense het 38 7:55181410-55181410 + - PATHOGENIC .96426 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000415559.1:p.Tyr756His ENST00000455089.5:c.2266T>C 7:g.55181410T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003116-T01-IM5 2719610 2578431 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51809537 COSM6926377 132562562 c.2906A>T p.D969V Substitution - Missense het 38 7:55201282-55201282 + - PATHOGENIC .99519 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Asp969Val ENST00000454757.6:c.2906A>T 7:g.55201282A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SJOS011_D 2372211 2235004 bone tibia NS NS osteosarcoma osteoblastic NS NS y COSV51845937 COSM5024343 132613210 c.2770T>C p.S924P Substitution - Missense 38 7:55200372-55200372 + - PATHOGENIC .91352 Confirmed somatic variant 24703847 NS primary 13 ENSP00000395243.3:p.Ser924Pro ENST00000454757.6:c.2770T>C 7:g.55200372T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007504-T01-IM5 2723789 2582610 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 2014_Lung_sq_82_T 2744953 2603656 lung NS NS NS carcinoma NS NS NS y COSV51818649 COSM7238502 99439041 c.1362G>T p.K454N Substitution - Missense 38 7:55160202-55160202 + - PATHOGENIC .92978 Confirmed somatic variant 583 NS primary 62 ENSP00000275493.2:p.Lys454Asn ENST00000275493.6:c.1362G>T 7:g.55160202G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-VQ-A8P2-01 2339964 2204947 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51820069 COSM6652271 132556093 c.1796C>T p.P599L Substitution - Missense 38 7:55172994-55172994 + - PATHOGENIC .98245 Confirmed somatic variant 541 NS primary 68 ENSP00000395243.3:p.Pro599Leu ENST00000454757.6:c.1796C>T 7:g.55172994C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008476-T01-IM5 2724590 2583411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1091707 1091707 1006529 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM26138 178387145 c.? p.L692P Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 2591495 2591495 2452455 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13447 178378778 c.? p.E709K Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Glu709Lys EGFR ENST00000275493.6 3633 3236 2876643 2876643 2731158 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51795112 COSM23633 99405507 c.2276T>A p.I759N Substitution - Missense 38 7:55174813-55174813 + - PATHOGENIC .99182 Confirmed somatic variant 29506987 circulating tumour NS 36 ENSP00000275493.2:p.Ile759Asn ENST00000275493.6:c.2276T>A 7:g.55174813T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CHG-100T 2634282 2494678 liver NS NS NS other neoplasm NS NS y COSV51842976 COSM6287773 133202708 c.1217G>A p.R406H Substitution - Missense 38 7:55160192-55160192 + - PATHOGENIC .98594 Confirmed somatic variant 660 NS primary 65 ENSP00000415559.1:p.Arg406His ENST00000455089.5:c.1217G>A 7:g.55160192G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BH-A18U-01 1899961 1788645 breast NS NS NS carcinoma NS NS NS y COSV99294745 COSM7670588 133241349 c.634G>A p.E212K Substitution - Missense 38 7:55154032-55154032 + - PATHOGENIC .97243 Confirmed somatic variant 414 fresh/frozen - NOS primary 72 ENSP00000415559.1:p.Glu212Lys ENST00000455089.5:c.634G>A 7:g.55154032G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD42101a 2894816 2749304 skin trunk NS NS malignant_melanoma superficial_spreading NS NS y COSV51793030 COSM133566 132578206 c.2372G>A p.R791H Substitution - Missense 38 7:55191756-55191756 + - PATHOGENIC .98912 Confirmed somatic variant 33024263 surgery-fixed metastasis ENSP00000395243.3:p.Arg791His ENST00000454757.6:c.2372G>A 7:g.55191756G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001328-T01-IM3 2717084 2575905 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51833335 COSM6916442 132562472 c.14G>C p.G5A Substitution - Missense het 38 7:55019291-55019291 + - NEUTRAL .0753 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly5Ala ENST00000454757.6:c.14G>C 7:g.55019291G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EE-A3AC-06 2121694 1995930 skin NS NS NS malignant_melanoma NS NS NS y COSV99295809 COSM7991924 132583245 c.2665C>A p.P889T Substitution - Missense 38 7:55198815-55198815 + - PATHOGENIC .96256 Confirmed somatic variant 540 NS NS 47 ENSP00000395243.3:p.Pro889Thr ENST00000454757.6:c.2665C>A 7:g.55198815C>A EGFR ENST00000275493.6 3633 3236 LC_C30 1863711 1754602 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 22975805 surgery fresh/frozen primary 38 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 TCGA-S9-A7IX-01 2263383 2130367 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 57 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001506-T01-IM3 2717427 2576248 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51844502 COSM6917412 132573836 c.2597G>C p.G866A Substitution - Missense het 38 7:55198747-55198747 + - PATHOGENIC .99519 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly866Ala ENST00000454757.6:c.2597G>C 7:g.55198747G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832120 COSM6493935 132583974 c.2251G>C p.G751R Substitution - Missense 38 7:55181395-55181395 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000395243.3:p.Gly751Arg ENST00000454757.6:c.2251G>C 7:g.55181395G>C EGFR ENST00000275493.6 3633 3236 P-0006124-T01-IM5 2722503 2581324 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51842040 COSM6948138 99418332 c.1077C>G p.F359L Substitution - Missense het 38 7:55156603-55156603 + - PATHOGENIC .96894 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Phe359Leu ENST00000275493.6:c.1077C>G 7:g.55156603C>G EGFR ENST00000275493.6 3633 3236 TCGA-14-1829-01 1338016 1248401 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 99388542 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 surgery fresh/frozen NS 57 ENSP00000275493.2:p.Thr363Ile ENST00000275493.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008215-T01-IM5 2724369 2583190 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51834499 COSM6845063 133203949 c.829G>A p.G277S Substitution - Missense het 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly277Ser ENST00000455089.5:c.829G>A 7:g.55155904G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003096-T01-IM5 2719590 2578411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Br215T 1313044 1223953 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51785554 COSM21688 133203816 c.836G>T p.R279L Substitution - Missense het 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 18772396 surgery - NOS primary 50 ENSP00000415559.1:p.Arg279Leu ENST00000455089.5:c.836G>T 7:g.55155911G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876643 2876643 2731158 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51795112 COSM23633 133231506 c.2141T>A p.I714N Substitution - Missense 38 7:55174813-55174813 + - PATHOGENIC .99182 Confirmed somatic variant 29506987 circulating tumour NS 36 ENSP00000415559.1:p.Ile714Asn ENST00000455089.5:c.2141T>A 7:g.55174813T>A EGFR ENST00000275493.6 3633 3236 1091698 1091698 1006520 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26133 178385018 c.? p.L747S Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS ENSP00000275493.2:p.Leu747Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD42099a 2894830 2749318 skin head_neck NS NS malignant_melanoma lentigo_maligna NS NS y COSV105110419 COSM9894626 133241674 c.2839C>T p.P947S Substitution - Missense 38 7:55201215-55201215 + - PATHOGENIC .99346 Confirmed somatic variant 33024263 surgery-fixed metastasis 60 ENSP00000415559.1:p.Pro947Ser ENST00000455089.5:c.2839C>T 7:g.55201215C>T EGFR ENST00000275493.6 3633 3236 1363-ca 2823137 2678991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 28818608 surgery-fixed NS 70 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 945812 945812 862338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 16144918 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1170517 1170517 1082651 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 19117057 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876611 2876611 2731126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105110312 COSM9869917 132578367 c.2017C>G p.L673V Substitution - Missense 38 7:55174011-55174011 + Yes PATHOGENIC .92276 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000395243.3:p.Leu673Val ENST00000454757.6:c.2017C>G 7:g.55174011C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD42099a 2894830 2749318 skin head_neck NS NS malignant_melanoma lentigo_maligna NS NS y COSV105110419 COSM9894626 132580589 c.2839C>T p.P947S Substitution - Missense 38 7:55201215-55201215 + - PATHOGENIC .99346 Confirmed somatic variant 33024263 surgery-fixed metastasis 60 ENSP00000395243.3:p.Pro947Ser ENST00000454757.6:c.2839C>T 7:g.55201215C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010754-T01-IM5 2787068 2644491 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51805749 COSM6976991 133203538 c.2509G>A p.A837T Substitution - Missense 38 7:55192784-55192784 + - PATHOGENIC .95513 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000415559.1:p.Ala837Thr ENST00000455089.5:c.2509G>A 7:g.55192784G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105110312 COSM9869917 132578367 c.2017C>G p.L673V Substitution - Missense 38 7:55174011-55174011 + Yes PATHOGENIC .92276 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000395243.3:p.Leu673Val ENST00000454757.6:c.2017C>G 7:g.55174011C>G EGFR ENST00000275493.6 3633 3236 TCGA-D3-A8GC-06 2262878 2129862 skin NS NS NS malignant_melanoma NS NS NS y COSV51822525 COSM6922832 99417488 c.1340C>T p.S447F Substitution - Missense 38 7:55160180-55160180 + - .61329 Confirmed somatic variant 540 NS NS 48 ENSP00000275493.2:p.Ser447Phe ENST00000275493.6:c.1340C>T 7:g.55160180C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1595810 1595810 1516607 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS n COSV51789625 COSM13197 133204854 c.2455G>A p.A819T Substitution - Missense hom 38 7:55191839-55191839 + - PATHOGENIC .9615 Confirmed somatic variant 16551849 surgery-fixed NS 55 ENSP00000415559.1:p.Ala819Thr ENST00000455089.5:c.2455G>A 7:g.55191839G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DK-AA75-01 2385754 2248586 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51771467 COSM7104388 133219211 c.942C>A p.F314L Substitution - Missense 38 7:55156603-55156603 + - PATHOGENIC .96682 Confirmed somatic variant 413 NS primary 82 ENSP00000415559.1:p.Phe314Leu ENST00000455089.5:c.942C>A 7:g.55156603C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009852-T01-IM5 2725690 2584511 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51768139 COSM21685 133205223 c.731C>A p.A244D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Asp ENST00000455089.5:c.731C>A 7:g.55154129C>A EGFR ENST00000275493.6 3633 3236 PCA0136 2580109 2441446 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51788967 COSM6005513 99424659 c.446G>A p.R149Q Substitution - Missense 38 7:55146627-55146627 + - PATHOGENIC .75281 Confirmed somatic variant 20579941 surgery fresh/frozen primary 54 ENSP00000275493.2:p.Arg149Gln ENST00000275493.6:c.446G>A 7:g.55146627G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920111 920111 837190 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 15623594 surgery-fixed NS 66 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876623 2876623 2731138 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 29506987 circulating tumour NS 86 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812133 2812133 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 circulating tumour NS 77 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-D3-A8GC-06 2262878 2129862 skin NS NS NS malignant_melanoma NS NS NS y COSV51822525 COSM6922832 133242841 c.1205C>T p.S402F Substitution - Missense 38 7:55160180-55160180 + - .61329 Confirmed somatic variant 540 NS NS 48 ENSP00000415559.1:p.Ser402Phe ENST00000455089.5:c.1205C>T 7:g.55160180C>T EGFR ENST00000275493.6 3633 3236 2150415 2150415 2019484 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 54 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591335 2591335 2452295 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591337 2591337 2452297 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 P-0003871-T01-IM5 2720365 2579186 skin NS NS NS malignant_melanoma NS NS NS n COSV51836372 COSM6931354 99435577 c.3010G>A p.E1004K Substitution - Missense het 38 7:55201251-55201251 + - PATHOGENIC .98827 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Glu1004Lys ENST00000275493.6:c.3010G>A 7:g.55201251G>A EGFR ENST00000275493.6 3633 3236 KD826 1005019 922231 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0155-01 1337821 1248206 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 133206295 c.775C>T p.H259Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 surgery fresh/frozen NS 61 ENSP00000415559.1:p.His259Tyr ENST00000455089.5:c.775C>T 7:g.55155850C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-EE-A2MR-06 2121688 1995924 skin NS NS NS malignant_melanoma NS NS NS y COSV51788720 COSM3639737 133257248 c.1399C>T p.P467S Substitution - Missense 38 7:55161534-55161534 + - NEUTRAL .03494 Confirmed somatic variant 540 NS NS 61 ENSP00000415559.1:p.Pro467Ser ENST00000455089.5:c.1399C>T 7:g.55161534C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV104369000 COSM9233361 132578288 c.352G>T p.A118S Substitution - Missense het 38 7:55143416-55143416 + - PATHOGENIC .99878 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000395243.3:p.Ala118Ser ENST00000454757.6:c.352G>T 7:g.55143416G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-25-2404-01 1474989 1398688 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV99292585 COSM7509017 133217081 c.1246G>A p.V416M Substitution - Missense 38 7:55160221-55160221 + - PATHOGENIC .98193 Confirmed somatic variant 21720365 331 NS primary 38 ENSP00000415559.1:p.Val416Met ENST00000455089.5:c.1246G>A 7:g.55160221G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-25-2404-01 1474989 1398688 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV99292585 COSM7509017 133217081 c.1246G>A p.V416M Substitution - Missense 38 7:55160221-55160221 + - PATHOGENIC .98193 Confirmed somatic variant 331 NS primary 38 ENSP00000415559.1:p.Val416Met ENST00000455089.5:c.1246G>A 7:g.55160221G>A EGFR ENST00000275493.6 3633 3236 P-0005585-T01-IM5 2721978 2580799 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51837327 COSM6944624 99374099 c.2991C>G p.F997L Substitution - Missense het 38 7:55201232-55201232 + - NEUTRAL .42217 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Phe997Leu ENST00000275493.6:c.2991C>G 7:g.55201232C>G EGFR ENST00000275493.6 3633 3236 B105-0-Tumor 2185749 2054046 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51776529 COSM1755314 99431721 c.1880G>A p.G627E Substitution - Missense 38 7:55165437-55165437 + - PATHOGENIC .99581 Confirmed somatic variant 581 NS NS ENSP00000275493.2:p.Gly627Glu ENST00000275493.6:c.1880G>A 7:g.55165437G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SJHYPO052-R 2590153 2451283 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 132554159 c.1144C>T p.R382C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 23334668 blood-bone marrow recurrent 16.3 ENSP00000395243.3:p.Arg382Cys ENST00000454757.6:c.1144C>T 7:g.55157734C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PCA1587 2861424 2716668 prostate NS NS NS carcinoma NS NS NS n COSV105111146 COSM9581090 132607756 c.1744G>C p.G582R Substitution - Missense 38 7:55165436-55165436 + - PATHOGENIC .99177 Confirmed somatic variant 32268276 circulating tumour NS ENSP00000395243.3:p.Gly582Arg ENST00000454757.6:c.1744G>C 7:g.55165436G>C EGFR ENST00000275493.6 3633 3236 TCGA-VQ-A8P2-01 2339964 2204947 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51820069 COSM6652271 99383430 c.1931C>T p.P644L Substitution - Missense 38 7:55172994-55172994 + - PATHOGENIC .98245 Confirmed somatic variant 541 NS primary 68 ENSP00000275493.2:p.Pro644Leu ENST00000275493.6:c.1931C>T 7:g.55172994C>T EGFR ENST00000275493.6 3633 3236 P-0004510-T01-IM5 2720910 2579731 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 P-0007897-T01-IM5 2724108 2582929 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982883 982883 898602 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011038-T01-IM5 2726676 2585497 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001328-T01-IM3 2717084 2575905 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471554 1471554 1395293 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A014-T-S52 2758140 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211140 1211140 1123008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0001914-T01-IM3 2718230 2577051 central_nervous_system brain NS NS glioma astrocytoma NS NS n COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense het 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 SJOS011_D 2372211 2235004 bone tibia NS NS osteosarcoma osteoblastic NS NS y COSV51845937 COSM5024343 99453482 c.2905T>C p.S969P Substitution - Missense 38 7:55200372-55200372 + - PATHOGENIC .91352 Confirmed somatic variant 24703847 NS primary 13 ENSP00000275493.2:p.Ser969Pro ENST00000275493.6:c.2905T>C 7:g.55200372T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007897-T01-IM5 2724108 2582929 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920032 920032 837111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense het 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 15623594 surgery fresh/frozen NS 76 ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004810 1004810 922022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16140420 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458683 1458683 1382658 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001296-T01-IM3 2717010 2575831 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876659 2876659 2731174 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002534-T01-IM3 2718800 2577621 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458679 1458679 1382654 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471544 1471544 1395283 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001252 1001252 918475 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152777 2152777 2021787 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920032 920032 837111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 76 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001123-T02-IM5 2719395 2578216 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982884 982884 898603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876652 2876652 2731167 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A001-T-S03 2757356 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2014_Lung_sq_82_T 2744953 2603656 lung NS NS NS carcinoma NS NS NS y COSV51818682 COSM7238574 133262059 c.2965C>A p.L989I Substitution - Missense 38 7:55201341-55201341 + - PATHOGENIC .99175 Confirmed somatic variant 583 NS primary 62 ENSP00000415559.1:p.Leu989Ile ENST00000455089.5:c.2965C>A 7:g.55201341C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007322-T01-IM5 2723661 2582482 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 J36 2815364 2671744 central_nervous_system brain NS NS glioma astrocytoma_Grade_II fibrillary NS y COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 29263181 surgery fresh/frozen NS 48 ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-2563-01 1337882 1248267 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 132553689 c.619C>T p.R207C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000395243.3:p.Arg207Cys ENST00000454757.6:c.619C>T 7:g.55154017C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1044283 1044283 960624 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152785 2152785 2021795 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876059 2876059 2730574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 77 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0008450-T01-IM5 2724567 2583388 skin NS NS NS malignant_melanoma NS NS NS n COSV51822498 COSM3266565 99412489 c.917C>T p.S306L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ser306Leu ENST00000275493.6:c.917C>T 7:g.55155857C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471537 1471537 1395276 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489249 1489249 1412407 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004996 1004996 922208 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982876 982876 898595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2150415 2150415 2019484 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 54 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0003512-T01-IM5 2719993 2578814 soft_tissue fibrous_tissue_and_uncertain_origin NS NS synovial_sarcoma NS NS NS n COSV51846648 COSM244213 99386285 c.2381C>A p.P794H Substitution - Missense het 38 7:55181390-55181390 + - PATHOGENIC .97291 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Pro794His ENST00000275493.6:c.2381C>A 7:g.55181390C>A EGFR ENST00000275493.6 3633 3236 2591335 2591335 2452295 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2591337 2591337 2452297 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2935-ca 2823135 2678989 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 28818608 surgery-fixed NS 60 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1170511 1170511 1082645 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 19117057 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DU-A5TT-01 2194423 2062701 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 70 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 P-0005076-T01-IM5 2721479 2580300 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51785733 COSM28575 99408096 c.2650G>A p.E884K Substitution - Missense het 38 7:55192790-55192790 + - PATHOGENIC .9655 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Glu884Lys ENST00000275493.6:c.2650G>A 7:g.55192790G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006863-T01-IM5 2723243 2582064 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51788393 COSM13979 133219516 c.2035G>A p.G679S Substitution - Missense het 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly679Ser ENST00000455089.5:c.2035G>A 7:g.55174029G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004400-T01-IM5 2720811 2579632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 2697837 2697837 2556741 breast NS NS NS carcinoma NS NS NS n COSV51811430 COSM6906106 99445979 c.1265A>G p.N422S Substitution - Missense 38 7:55157720-55157720 + - PATHOGENIC .99784 Confirmed somatic variant 29349598 NS NS ENSP00000275493.2:p.Asn422Ser ENST00000275493.6:c.1265A>G 7:g.55157720A>G EGFR ENST00000275493.6 3633 3236 2014_Lung_sq_82_T 2744953 2603656 lung NS NS NS carcinoma NS NS NS y COSV51818682 COSM7238574 99439059 c.3100C>A p.L1034I Substitution - Missense 38 7:55201341-55201341 + - PATHOGENIC .99175 Confirmed somatic variant 583 NS primary 62 ENSP00000275493.2:p.Leu1034Ile ENST00000275493.6:c.3100C>A 7:g.55201341C>A EGFR ENST00000275493.6 3633 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51770694 COSM20891 99391373 c.2386G>A p.G796S Substitution - Missense het 38 7:55181395-55181395 + - PATHOGENIC .98244 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000275493.2:p.Gly796Ser ENST00000275493.6:c.2386G>A 7:g.55181395G>A EGFR ENST00000275493.6 3633 3236 2777771 2777771 2635906 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSM26144 178389266 c.? p.G874S Substitution - Missense + - Confirmed somatic variant 30041611 surgery-fixed NS ENSP00000275493.2:p.Gly874Ser EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 132551512 c.2113G>C p.A705P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000395243.3:p.Ala705Pro ENST00000454757.6:c.2113G>C 7:g.55174785G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002649-T01-IM3 2829504 2685319 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51794834 COSM5575633 133214600 c.2738G>A p.R913H Substitution - Missense 38 7:55200340-55200340 + - PATHOGENIC .99504 Confirmed somatic variant 30205045 surgery-fixed primary 53 ENSP00000415559.1:p.Arg913His ENST00000455089.5:c.2738G>A 7:g.55200340G>A EGFR ENST00000275493.6 3633 3236 P-0006713-T01-IM5 2723092 2581913 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51784387 COSM6953025 99446005 c.70G>T p.A24S Substitution - Missense het 38 7:55019347-55019347 + - NEUTRAL .37583 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ala24Ser ENST00000275493.6:c.70G>T 7:g.55019347G>T EGFR ENST00000275493.6 3633 3236 T3010 2658443 2518602 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 99383629 c.1580G>A p.R527Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 74.08 ENSP00000275493.2:p.Arg527Gln ENST00000275493.6:c.1580G>A 7:g.55161580G>A EGFR ENST00000275493.6 3633 3236 2152774 2152774 2021784 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982885 982885 898604 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 16786 1423727 1333755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EE-A2M7-06 2121673 1995909 skin NS NS NS malignant_melanoma NS NS NS y COSV51790699 COSM3639729 132569857 c.656G>A p.C219Y Substitution - Missense 38 7:55154054-55154054 + - PATHOGENIC .99369 Confirmed somatic variant 540 NS NS 66 ENSP00000395243.3:p.Cys219Tyr ENST00000454757.6:c.656G>A 7:g.55154054G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0012262-T01-IM5 2727369 2586190 salivary_gland major NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51794983 COSM1451619 132592301 c.3152C>T p.S1051F Substitution - Missense het 38 7:55205271-55205271 + - NEUTRAL .09807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ser1051Phe ENST00000454757.6:c.3152C>T 7:g.55205271C>T EGFR ENST00000275493.6 3633 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51774667 COSM53194 99382658 c.2197C>T p.P733S Substitution - Missense het 38 7:55174734-55174734 + - PATHOGENIC .99806 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000275493.2:p.Pro733Ser ENST00000275493.6:c.2197C>T 7:g.55174734C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005725-T01-IM5 2722109 2580930 NS NS NS NS malignant_melanoma NS NS NS n COSV51776559 COSM4892884 133209480 c.298C>T p.P100S Substitution - Missense het 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Pro100Ser ENST00000455089.5:c.298C>T 7:g.55143362C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51865283 COSM6970485 133275963 c.188G>A p.G63E Substitution - Missense het 38 7:55142385-55142385 + - PATHOGENIC .95671 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Gly63Glu ENST00000455089.5:c.188G>A 7:g.55142385G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EXTERN_MELA_20140924_131 2839485 2695251 skin scalp NS NS malignant_melanoma NS NS NS y COSV51806564 COSM6920868 133211798 c.1871G>A p.R624Q Substitution - Missense 38 7:55173069-55173069 + - PATHOGENIC .99699 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000415559.1:p.Arg624Gln ENST00000455089.5:c.1871G>A 7:g.55173069G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003871-T01-IM5 2720365 2579186 skin NS NS NS malignant_melanoma NS NS NS n COSV51836372 COSM6931354 132595392 c.2875G>A p.E959K Substitution - Missense het 38 7:55201251-55201251 + - PATHOGENIC .98827 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Glu959Lys ENST00000454757.6:c.2875G>A 7:g.55201251G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BP-4354-01 2120471 1994707 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51815927 COSM24971 133219942 c.2378T>C p.L793P Substitution - Missense 38 7:55191762-55191762 + - PATHOGENIC .97813 Confirmed somatic variant 416 NS NS 40 ENSP00000415559.1:p.Leu793Pro ENST00000455089.5:c.2378T>C 7:g.55191762T>C EGFR ENST00000275493.6 3633 3236 TCGA-DU-A5TT-01 2194423 2062701 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 70 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 132557758 c.2018T>A p.L673Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000395243.3:p.Leu673Gln ENST00000454757.6:c.2018T>A 7:g.55174012T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003070-T02-IM5 2719579 2578400 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-2567-01 1337886 1248271 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51816377 COSM3412194 132548327 c.1651C>T p.P551S Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99531 Confirmed somatic variant 329 surgery fresh/frozen NS 65 ENSP00000395243.3:p.Pro551Ser ENST00000454757.6:c.1651C>T 7:g.55165343C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S07-39193-TP 2366575 2229458 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51792018 COSM4992972 133206283 c.2999C>T p.S1000F Substitution - Missense het 38 7:55201754-55201754 + - PATHOGENIC .97067 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000415559.1:p.Ser1000Phe ENST00000455089.5:c.2999C>T 7:g.55201754C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003693-T02-IM5 2720181 2579002 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51805704 COSM6930161 132551374 c.3237C>G p.H1079Q Substitution - Missense het 38 7:55205356-55205356 + - NEUTRAL .41128 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.His1079Gln ENST00000454757.6:c.3237C>G 7:g.55205356C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2014_Lung_sq_15_T 2744886 2603589 lung NS NS NS carcinoma NS NS NS y COSV51805367 COSM3950642 133234090 c.904G>A p.D302N Substitution - Missense 38 7:55156565-55156565 + - PATHOGENIC .82248 Confirmed somatic variant 583 NS primary 72 ENSP00000415559.1:p.Asp302Asn ENST00000455089.5:c.904G>A 7:g.55156565G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489251 1489251 1412409 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471555 1471555 1395294 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876066 2876066 2730581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920028 920028 837107 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 53 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005845-T02-IM5 2722231 2581052 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 25 897186 814809 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003096-T01-IM5 2719590 2578411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-D7-6521-01 2198059 2066337 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51778897 COSM3881800 132597165 c.253G>A p.V85M Substitution - Missense 38 7:55143317-55143317 + - PATHOGENIC .99051 Confirmed somatic variant 541 NS NS 65 ENSP00000395243.3:p.Val85Met ENST00000454757.6:c.253G>A 7:g.55143317G>A EGFR ENST00000275493.6 3633 3236 CHG-100T 2634282 2494678 liver NS NS NS other neoplasm NS NS y COSV51842976 COSM6287773 99374039 c.1352G>A p.R451H Substitution - Missense 38 7:55160192-55160192 + - PATHOGENIC .98594 Confirmed somatic variant 660 NS primary 65 ENSP00000275493.2:p.Arg451His ENST00000275493.6:c.1352G>A 7:g.55160192G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Pat_01_B 2492838 2355452 NS NS NS NS malignant_melanoma NS NS NS y COSV51817615 COSM5872885 132574294 c.2654G>A p.G885E Substitution - Missense 38 7:55198804-55198804 + - PATHOGENIC .99081 Confirmed somatic variant 24265153 surgery-fixed NS 45 ENSP00000395243.3:p.Gly885Glu ENST00000454757.6:c.2654G>A 7:g.55198804G>A EGFR ENST00000275493.6 3633 3236 TCGA-OX-A56R-01 2178260 2046558 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 68 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914583 914583 832032 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51861444 COSM13007 133203258 c.2200_2201delinsTT p.G734F Substitution - Missense hom 38 7:55181344-55181345 + - Confirmed somatic variant 15788655 surgery fresh/frozen primary 81 ENSP00000415559.1:p.Gly734Phe ENST00000455089.5:c.2200_2201delinsTT 7:g.55181344_55181345delinsTT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004688-T01-IM5 2721089 2579910 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51824002 COSM6937752 132572106 c.2659C>T p.R887C Substitution - Missense het 38 7:55198809-55198809 + - PATHOGENIC .91422 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Arg887Cys ENST00000454757.6:c.2659C>T 7:g.55198809C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471553 1471553 1395292 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006139-T01-IM5 2722519 2581340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458697 1458697 1382672 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A062-T-S27 2757400 2615999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152758 2152758 2021768 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152763 2152763 2021773 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460156 1460156 1384033 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876610 2876610 2731125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 99388191 c.2389T>A p.C797S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2389T>A 7:g.55181398T>A EGFR ENST00000275493.6 3633 3236 2876608 2876608 2731123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 99388191 c.2389T>A p.C797S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2389T>A 7:g.55181398T>A EGFR ENST00000275493.6 3633 3236 1312386 1312386 1223295 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 83 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2876610 2876610 2731125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 99392455 c.2375T>A p.L792H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000275493.2:p.Leu792His ENST00000275493.6:c.2375T>A 7:g.55181384T>A EGFR ENST00000275493.6 3633 3236 2876608 2876608 2731123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 99392455 c.2375T>A p.L792H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Confirmed somatic variant 29506987 circulating tumour NS ENSP00000275493.2:p.Leu792His ENST00000275493.6:c.2375T>A 7:g.55181384T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DK-AA6L-01 2385744 2248576 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51816076 COSM53287 133225558 c.1996G>A p.E666K Substitution - Missense 38 7:55173990-55173990 + - PATHOGENIC .97511 Confirmed somatic variant 413 NS primary 48 ENSP00000415559.1:p.Glu666Lys ENST00000455089.5:c.1996G>A 7:g.55173990G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P147 2072600 1951955 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 44 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Br140X 1313029 1223938 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 xenograft primary 41 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006210-T01-IM5 2722589 2581410 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 148 898384 815996 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458688 1458688 1382663 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811980 2811980 2668502 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003116-T01-IM5 2719610 2578431 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876611 2876611 2731126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471563 1471563 1395302 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1004999 1004999 922211 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489238 1489238 1412396 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LC_C29 1863710 1754601 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982860 982860 898579 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0007754-T01-IM5 2723998 2582819 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1460136 1460136 1384013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EX01T 2653305 2513432 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS primary 58.5 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 914592 914592 832041 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 82 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A001-T-S02 2757355 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0003096-T01-IM5 2719590 2578411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 Br215T 1313044 1223953 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51785554 COSM21688 99375522 c.971G>T p.R324L Substitution - Missense het 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 18772396 surgery - NOS primary 50 ENSP00000275493.2:p.Arg324Leu ENST00000275493.6:c.971G>T 7:g.55155911G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T3010 2658443 2518602 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 133212226 c.1445G>A p.R482Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 74.08 ENSP00000415559.1:p.Arg482Gln ENST00000455089.5:c.1445G>A 7:g.55161580G>A EGFR ENST00000275493.6 3633 3236 CC34 2856045 2711446 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSM9516329 178391378 c.? p.L933P Substitution - Missense + - Confirmed somatic variant 29665843 surgery fresh/frozen NS 69 ENSP00000275493.2:p.Leu933Pro EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004400-T01-IM5 2720811 2579632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006150-T01-IM5 2722528 2581349 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51857876 COSM6948549 132562329 c.3217G>T p.A1073S Substitution - Missense het 38 7:55205336-55205336 + - NEUTRAL .12775 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Ala1073Ser ENST00000454757.6:c.3217G>T 7:g.55205336G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Br124X 1313013 1223922 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 xenograft primary 44 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-2557-01 1337877 1248262 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 76 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1589266 1589266 1510420 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51851529 COSM133149 132551170 c.1985T>C p.L662S Substitution - Missense 38 7:55173979-55173979 + - PATHOGENIC .97336 Confirmed somatic variant 22026926 surgery fresh/frozen NS ENSP00000395243.3:p.Leu662Ser ENST00000454757.6:c.1985T>C 7:g.55173979T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1461 2602435 2463311 large_intestine right NS NS carcinoma adenocarcinoma NS NS n COSV51813913 COSM6023901 133211053 c.344A>C p.N115T Substitution - Missense 38 7:55143408-55143408 + - PATHOGENIC .92454 Confirmed somatic variant 27121310 surgery fresh/frozen NS 47 ENSP00000415559.1:p.Asn115Thr ENST00000455089.5:c.344A>C 7:g.55143408A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T3064 2296168 2161771 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51804131 COSM4680403 132560266 c.3475A>C p.S1159R Substitution - Missense 38 7:55205594-55205594 + - PATHOGENIC .82773 Confirmed somatic variant 25344691 NS NS 75.5 ENSP00000395243.3:p.Ser1159Arg ENST00000454757.6:c.3475A>C 7:g.55205594A>C EGFR ENST00000275493.6 3633 3236 P-0007100-T01-IM5 2723473 2582294 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51776957 COSM6955986 99424823 c.3121A>G p.T1041A Substitution - Missense het 38 7:55201741-55201741 + - PATHOGENIC .92147 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr1041Ala ENST00000275493.6:c.3121A>G 7:g.55201741A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2857072 2857072 2712372 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV105110417 COSM9522635 132580525 c.2371C>G p.R791G Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .96487 Confirmed somatic variant 31937902 surgery-fixed NS 17 ENSP00000395243.3:p.Arg791Gly ENST00000454757.6:c.2371C>G 7:g.55191755C>G EGFR ENST00000275493.6 3633 3236 P-0003070-T02-IM5 2719579 2578400 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876033 2876033 2730548 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 44 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008310-T01-IM5 2724436 2583257 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0007504-T01-IM5 2723789 2582610 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD23564a 2213146 2081276 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV51788393 COSM13979 132563273 c.2035G>A p.G679S Substitution - Missense 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 27135926 NS NS ENSP00000395243.3:p.Gly679Ser ENST00000454757.6:c.2035G>A 7:g.55174029G>A EGFR ENST00000275493.6 3633 3236 2591459 2591459 2452419 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468652 1468652 1392403 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1589269 1589269 1510423 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51843707 COSM28601 132551449 c.2000T>C p.F667S Substitution - Missense 38 7:55173994-55173994 + - PATHOGENIC .9621 Confirmed somatic variant 22026926 surgery fresh/frozen NS ENSP00000395243.3:p.Phe667Ser ENST00000454757.6:c.2000T>C 7:g.55173994T>C EGFR ENST00000275493.6 3633 3236 P-0004400-T01-IM5 2720811 2579632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1594190 1594190 1515164 upper_aerodigestive_tract pharynx oropharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 19726454 surgery fresh/frozen primary 70 ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2697837 2697837 2556741 breast NS NS NS carcinoma NS NS NS n COSV51811430 COSM6906106 133269395 c.1130A>G p.N377S Substitution - Missense 38 7:55157720-55157720 + - PATHOGENIC .99784 Confirmed somatic variant 29349598 NS NS ENSP00000415559.1:p.Asn377Ser ENST00000455089.5:c.1130A>G 7:g.55157720A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_C30 1863711 1754602 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 22975805 surgery fresh/frozen primary 38 ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1179542 1179542 1091504 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51768413 COSM25861 99431341 c.2274A>C p.E758D Substitution - Missense het 38 7:55174811-55174811 + - PATHOGENIC .88475 Confirmed somatic variant 18985444 surgery - NOS primary 72 ENSP00000275493.2:p.Glu758Asp ENST00000275493.6:c.2274A>C 7:g.55174811A>C EGFR ENST00000275493.6 3633 3236 2299102 2299102 2164430 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 24594201 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914588 914588 832037 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914591 914591 832040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 961854 961854 878138 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16467080 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1165892 1165892 1078206 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16407879 surgery - NOS metastasis 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489239 1489239 1412397 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 41 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920035 920035 837114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 52 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152796 2152796 2021806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152786 2152786 2021796 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002659-T01-IM3 2718905 2577726 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51775381 COSM6923532 132589979 c.914C>G p.S305C Substitution - Missense het 38 7:55156575-55156575 + - PATHOGENIC .99062 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ser305Cys ENST00000454757.6:c.914C>G 7:g.55156575C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-VQ-A8P2-01 2339964 2204947 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51820069 COSM6652271 133212046 c.1796C>T p.P599L Substitution - Missense 38 7:55172994-55172994 + - PATHOGENIC .98245 Confirmed somatic variant 541 NS primary 68 ENSP00000415559.1:p.Pro599Leu ENST00000455089.5:c.1796C>T 7:g.55172994C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EXTERN_MELA_20140526_084 2839361 2695127 skin trunk NS NS malignant_melanoma NS NS NS y COSV104577151 COSM9446111 133221742 c.2087_2088delinsGT p.P696R Substitution - Missense 38 7:55174759-55174760 + - Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000415559.1:p.Pro696Arg ENST00000455089.5:c.2087_2088delinsGT 7:g.55174759_55174760delinsGT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876066 2876066 2730581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 75 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009655-T01-IM5 2725548 2584369 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2115531 2115531 1989775 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003693-T01-IM5 2720182 2579003 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51805704 COSM6930161 132551374 c.3237C>G p.H1079Q Substitution - Missense het 38 7:55205356-55205356 + - NEUTRAL .41128 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.His1079Gln ENST00000454757.6:c.3237C>G 7:g.55205356C>G EGFR ENST00000275493.6 3633 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51767677 COSM25016 99381289 c.2335G>A p.G779S Substitution - Missense het 38 7:55181344-55181344 + - PATHOGENIC .98244 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000275493.2:p.Gly779Ser ENST00000275493.6:c.2335G>A 7:g.55181344G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-OX-A56R-01 2178260 2046558 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 68 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 IGC-03-1030 2662287 2522411 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51787961 COSM6530131 133234506 c.1760G>C p.G587A Substitution - Missense 38 7:55171189-55171189 + - PATHOGENIC .98448 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000415559.1:p.Gly587Ala ENST00000455089.5:c.1760G>C 7:g.55171189G>C EGFR ENST00000275493.6 3633 3236 P-0004944-T02-IM5 2721354 2580175 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843300 COSM6949613 99413737 c.937G>T p.A313S Substitution - Missense het 38 7:55155877-55155877 + - NEUTRAL .06397 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Ala313Ser ENST00000275493.6:c.937G>T 7:g.55155877G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004510-T01-IM5 2720910 2579731 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 Br140X 1313029 1223938 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 xenograft primary 41 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 P147 2072600 1951955 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 44 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 14_S4 2902121 2756359 autonomic_ganglia NS NS NS neuroblastoma NS NS NS n COSV105863896 COSM9976114 133222490 c.683C>G p.T228S Substitution - Missense 38 7:55154081-55154081 + - PATHOGENIC .94747 Confirmed somatic variant 33381456 circulating tumour primary 7 ENSP00000415559.1:p.Thr228Ser ENST00000455089.5:c.683C>G 7:g.55154081C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AX-A06F-01 2198328 2066606 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99294241 COSM8943299 132581245 c.575C>A p.A192D Substitution - Missense 38 7:55152627-55152627 + - PATHOGENIC .99353 Confirmed somatic variant 419 NS NS 59 ENSP00000395243.3:p.Ala192Asp ENST00000454757.6:c.575C>A 7:g.55152627C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PTC-7C 2185970 2054267 thyroid NS NS NS other neoplasm NS NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 589 NS NS ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-0174-01 1910190 1798481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51773690 COSM3412198 99443062 c.1841G>A p.G614D Substitution - Missense 38 7:55165398-55165398 + - NEUTRAL .00947 Confirmed somatic variant 329 fresh/frozen - NOS primary 54 ENSP00000275493.2:p.Gly614Asp ENST00000275493.6:c.1841G>A 7:g.55165398G>A EGFR ENST00000275493.6 3633 3236 P-0001506-T01-IM3 2717427 2576248 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51844512 COSM6917413 99405889 c.2835G>A p.M945I Substitution - Missense het 38 7:55198850-55198850 + - PATHOGENIC .99081 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Met945Ile ENST00000275493.6:c.2835G>A 7:g.55198850G>A EGFR ENST00000275493.6 3633 3236 2014_Lung_sq_15_T 2744886 2603589 lung NS NS NS carcinoma NS NS NS y COSV51805367 COSM3950642 99407361 c.1039G>A p.D347N Substitution - Missense 38 7:55156565-55156565 + - PATHOGENIC .82248 Confirmed somatic variant 583 NS primary 72 ENSP00000275493.2:p.Asp347Asn ENST00000275493.6:c.1039G>A 7:g.55156565G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005127-T01-IM5 2721532 2580353 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51800313 COSM5608354 132549848 c.2137G>A p.E713K Substitution - Missense het 38 7:55174809-55174809 + - PATHOGENIC .99476 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Glu713Lys ENST00000454757.6:c.2137G>A 7:g.55174809G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008577-T02-IM5 2724678 2583499 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-L9-A50W-01 2263346 2130330 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS primary 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_C24 1863705 1754596 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1322267 1322267 1233154 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 84 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1322273 1322273 1233160 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 43 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 5-RS 2060455 1940662 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma Richter_transformation NS y COSV51773206 COSM28603 99389206 c.2293G>A p.V765M Substitution - Missense 38 7:55181302-55181302 + - PATHOGENIC .97963 Confirmed somatic variant 24127483 blood-bone marrow primary 69 ENSP00000275493.2:p.Val765Met ENST00000275493.6:c.2293G>A 7:g.55181302G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-2565-01 1337884 1248269 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471539 1471539 1395278 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006561-T02-IM5 2722939 2581760 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982872 982872 898591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206735 1206735 1118613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001914-T01-IM3 2718230 2577051 central_nervous_system brain NS NS glioma astrocytoma NS NS n COSV51779794 COSM53264 132559797 c.2039C>T p.T680M Substitution - Missense het 38 7:55174033-55174033 + - PATHOGENIC .97744 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr680Met ENST00000454757.6:c.2039C>T 7:g.55174033C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001442-T02-IM5 2719422 2578243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011226-T01-IM5 2726843 2585664 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51842174 COSM6979569 133212868 c.1475A>T p.D492V Substitution - Missense het 38 7:55161610-55161610 + - PATHOGENIC .78722 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Asp492Val ENST00000455089.5:c.1475A>T 7:g.55161610A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876608 2876608 2731123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876610 2876610 2731125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001506-T01-IM3 2717427 2576248 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51844512 COSM6917413 133231956 c.2700G>A p.M900I Substitution - Missense het 38 7:55198850-55198850 + - PATHOGENIC .99081 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Met900Ile ENST00000455089.5:c.2700G>A 7:g.55198850G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206766 1206766 1118644 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005034-T01-IM5 2721439 2580260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 EX01T 2653305 2513432 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS primary 58.5 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A014-T-S55 2758141 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471542 1471542 1395281 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004714-T01-IM5 2721118 2579939 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001442-T02-IM5 2719422 2578243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001259 1001259 918482 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0002659-T01-IM3 2718905 2577726 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51775381 COSM6923532 99428513 c.1049C>G p.S350C Substitution - Missense het 38 7:55156575-55156575 + - PATHOGENIC .99062 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ser350Cys ENST00000275493.6:c.1049C>G 7:g.55156575C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV104369000 COSM9233361 133238526 c.352G>T p.A118S Substitution - Missense het 38 7:55143416-55143416 + - PATHOGENIC .99878 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000415559.1:p.Ala118Ser ENST00000455089.5:c.352G>T 7:g.55143416G>T EGFR ENST00000275493.6 3633 3236 2675050 2675050 2534325 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 29110836 surgery-fixed NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1002742 1002742 919959 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense hom + - Confirmed somatic variant 16115929 surgery-fixed NS 34 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2115521 2115521 1989765 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1091704 1091704 1006526 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0001514-T01-IM3 2717445 2576266 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0005034-T01-IM5 2721439 2580260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982871 982871 898590 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206766 1206766 1118644 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1460138 1460138 1384015 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0000280-T01-IM3 2714952 2573773 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0009864-T01-IM5 2725703 2584524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920023 920023 837102 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 82 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 KD514 1005018 922230 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458701 1458701 1382676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876610 2876610 2731125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD6313a 1483843 1407469 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_ringed_sideroblasts NS n COSV51819755 COSM4384123 133276758 c.1466A>C p.E489A Substitution - Missense 38 7:55161601-55161601 + - PATHOGENIC .82008 Confirmed somatic variant 24030381 NS NS ENSP00000415559.1:p.Glu489Ala ENST00000455089.5:c.1466A>C 7:g.55161601A>C EGFR ENST00000275493.6 3633 3236 112503 1520680 1443055 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20668451 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1001258 1001258 918481 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489248 1489248 1412406 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0004342-T01-IM5 2720749 2579570 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1063622 1063622 979667 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 53 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001914-T01-IM3 2718230 2577051 central_nervous_system brain NS NS glioma astrocytoma NS NS n COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense het 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007018-T01-IM5 2723393 2582214 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765787 COSM2149971 132551380 c.775C>T p.H259Y Substitution - Missense het 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.His259Tyr ENST00000454757.6:c.775C>T 7:g.55155850C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005511-T01-IM5 2721903 2580724 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51836402 COSM6944131 132566103 c.2219C>G p.T740S Substitution - Missense het 38 7:55181363-55181363 + - PATHOGENIC .951 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Thr740Ser ENST00000454757.6:c.2219C>G 7:g.55181363C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876595 2876595 2731110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 CHG-2015-31289T 2634363 2494759 liver NS NS NS other neoplasm NS NS y COSV51783393 COSM6237886 99377089 c.2475G>T p.M825I Substitution - Missense 38 7:55191724-55191724 + - PATHOGENIC .9903 Confirmed somatic variant 660 NS primary 45 ENSP00000275493.2:p.Met825Ile ENST00000275493.6:c.2475G>T 7:g.55191724G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PCA1587 2861424 2716668 prostate NS NS NS carcinoma NS NS NS n COSV105111146 COSM9581090 133272291 c.1744G>C p.G582R Substitution - Missense 38 7:55165436-55165436 + - PATHOGENIC .99177 Confirmed somatic variant 32268276 circulating tumour NS ENSP00000415559.1:p.Gly582Arg ENST00000455089.5:c.1744G>C 7:g.55165436G>C EGFR ENST00000275493.6 3633 3236 P-0011333-T01-IM5 2726929 2585750 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51864136 COSM6980296 99381488 c.3025G>T p.D1009Y Substitution - Missense het 38 7:55201266-55201266 + - PATHOGENIC .98461 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Asp1009Tyr ENST00000275493.6:c.3025G>T 7:g.55201266G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV104369001 COSM9233242 132578298 c.2011A>G p.K671E Substitution - Missense het 38 7:55174005-55174005 + - PATHOGENIC .95934 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000395243.3:p.Lys671Glu ENST00000454757.6:c.2011A>G 7:g.55174005A>G EGFR ENST00000275493.6 3633 3236 P-0011544-T01-IM5 2727116 2585937 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51774354 COSM6981709 99452468 c.951G>C p.E317D Substitution - Missense het 38 7:55155891-55155891 + - PATHOGENIC .93673 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Glu317Asp ENST00000275493.6:c.951G>C 7:g.55155891G>C EGFR ENST00000275493.6 3633 3236 019T 2067099 1946896 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51840438 COSM1727959 99395756 c.374A>G p.Y125C Substitution - Missense 38 7:55143438-55143438 + - PATHOGENIC .99088 Confirmed somatic variant 23788652 surgery - NOS primary ENSP00000275493.2:p.Tyr125Cys ENST00000275493.6:c.374A>G 7:g.55143438A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD8934a 1595624 1516507 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51847987 COSM4384128 132558569 c.2731G>A p.D911N Substitution - Missense 38 7:55200333-55200333 + - PATHOGENIC .99504 Confirmed somatic variant 24030381 NS NS ENSP00000395243.3:p.Asp911Asn ENST00000454757.6:c.2731G>A 7:g.55200333G>A EGFR ENST00000275493.6 3633 3236 2876610 2876610 2731125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876608 2876608 2731123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0005034-T01-IM5 2721439 2580260 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1206766 1206766 1118644 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PCSI_0588_Pa_P_526 2507080 2369416 pancreas NS NS NS carcinoma NS NS NS y COSV51770777 COSM28286 133220429 c.2359C>T p.R787C Substitution - Missense 38 7:55191743-55191743 + - PATHOGENIC .95135 Confirmed somatic variant 382 NS primary 78 ENSP00000415559.1:p.Arg787Cys ENST00000455089.5:c.2359C>T 7:g.55191743C>T EGFR ENST00000275493.6 3633 3236 P-0007813-T01-IM5 2724038 2582859 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767730 COSM6548312 99381402 c.662G>T p.G221V Substitution - Missense het 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000275493.2:p.Gly221Val ENST00000275493.6:c.662G>T 7:g.55152579G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A102-T-S29 2757413 2616002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002783-T01-IM3 2719014 2577835 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 16724 1423709 1333737 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008664-T01-IM5 2724728 2583549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982862 982862 898581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103792 1103792 1018044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003573-T02-IM5 2720059 2578880 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004983 1004983 922195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005264-T01-IM5 2721663 2580484 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 NS metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A028-T-S21 2757396 2615998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152772 2152772 2021782 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043303 1043303 959644 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17186532 surgery-fixed NS 57 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PCA1587 2861424 2716668 prostate NS NS NS carcinoma NS NS NS n COSV105111148 COSM9581094 132607780 c.1885G>T p.V629F Substitution - Missense 38 7:55173083-55173083 + - PATHOGENIC .97182 Confirmed somatic variant 32268276 circulating tumour NS ENSP00000395243.3:p.Val629Phe ENST00000454757.6:c.1885G>T 7:g.55173083G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-14-1829-01 1338016 1248401 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 132560457 c.953C>T p.T318I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 surgery fresh/frozen NS 57 ENSP00000395243.3:p.Thr318Ile ENST00000454757.6:c.953C>T 7:g.55156614C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PCSI_0590_Pa_P_526 2507081 2369417 pancreas NS NS NS carcinoma NS NS NS y COSV51771539 COSM5760860 132616788 c.1570A>G p.I524V Substitution - Missense 38 7:55163806-55163806 + - NEUTRAL .01956 Confirmed somatic variant 382 NS primary 73 ENSP00000395243.3:p.Ile524Val ENST00000454757.6:c.1570A>G 7:g.55163806A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1322232 1322232 1233119 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51806057 COSM41603 133241556 c.1999T>C p.F667L Substitution - Missense 38 7:55173993-55173993 + - PATHOGENIC .92149 Confirmed somatic variant 19844187 surgery-fixed primary 43 ENSP00000415559.1:p.Phe667Leu ENST00000455089.5:c.1999T>C 7:g.55173993T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SC-her2-051 2313868 2179064 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51850832 COSM4943273 132613191 c.705C>A p.N235K Substitution - Missense 38 7:55154103-55154103 + - PATHOGENIC .93631 Confirmed somatic variant 24185512 surgery fresh/frozen metastasis ENSP00000395243.3:p.Asn235Lys ENST00000454757.6:c.705C>A 7:g.55154103C>A EGFR ENST00000275493.6 3633 3236 PCSI_0590_Pa_P_526 2507081 2369417 pancreas NS NS NS carcinoma NS NS NS y COSV51771539 COSM5760860 99456194 c.1705A>G p.I569V Substitution - Missense 38 7:55163806-55163806 + - NEUTRAL .01956 Confirmed somatic variant 382 NS primary 73 ENSP00000275493.2:p.Ile569Val ENST00000275493.6:c.1705A>G 7:g.55163806A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-S9-A7IX-01 2263383 2130367 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 57 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_C30 1863711 1754602 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 22975805 surgery fresh/frozen primary 38 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206723 1206723 1118601 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766928 COSM12718 132551704 c.2045A>G p.Y682C Substitution - Missense 38 7:55174039-55174039 + - PATHOGENIC .97626 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Tyr682Cys ENST00000454757.6:c.2045A>G 7:g.55174039A>G EGFR ENST00000275493.6 3633 3236 P-0004400-T01-IM5 2720811 2579632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006124-T01-IM5 2722503 2581324 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51842040 COSM6948138 133243559 c.942C>G p.F314L Substitution - Missense het 38 7:55156603-55156603 + - PATHOGENIC .96894 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Phe314Leu ENST00000455089.5:c.942C>G 7:g.55156603C>G EGFR ENST00000275493.6 3633 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 99385331 c.2153T>A p.L718Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000275493.2:p.Leu718Gln ENST00000275493.6:c.2153T>A 7:g.55174012T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002783-T01-IM3 2719014 2577835 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-14-1455-01 2178074 2046372 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 132560457 c.953C>T p.T318I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 NS NS 61 ENSP00000395243.3:p.Thr318Ile ENST00000454757.6:c.953C>T 7:g.55156614C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0649-01 1337849 1248234 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51791901 COSM2151461 132581011 c.856G>A p.G286R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .96902 Confirmed somatic variant 329 surgery fresh/frozen NS 73 ENSP00000395243.3:p.Gly286Arg ENST00000454757.6:c.856G>A 7:g.55155931G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152758 2152758 2021768 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51836903 COSM3734670 132552557 c.2294G>C p.G765A Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98511 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Gly765Ala ENST00000454757.6:c.2294G>C 7:g.55181438G>C EGFR ENST00000275493.6 3633 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105111127 COSM9869918 99458034 c.2374C>G p.L792V Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .95352 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000275493.2:p.Leu792Val ENST00000275493.6:c.2374C>G 7:g.55181383C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003108-T01-IM5 2829558 2685373 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51866279 COSM6926300 133206418 c.530G>A p.R177H Substitution - Missense 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 30205045 surgery-fixed metastasis 37 ENSP00000415559.1:p.Arg177His ENST00000455089.5:c.530G>A 7:g.55152582G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51767677 COSM25016 132554273 c.2200G>A p.G734S Substitution - Missense het 38 7:55181344-55181344 + - PATHOGENIC .98244 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000395243.3:p.Gly734Ser ENST00000454757.6:c.2200G>A 7:g.55181344G>A EGFR ENST00000275493.6 3633 3236 1091712 1091712 1006534 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26141 178391800 c.? p.V726M Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004510-T01-IM5 2720910 2579731 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 TCGA-06-2565-01 1337884 1248269 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772147 COSM375343 99393933 c.1934C>G p.S645C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000275493.2:p.Ser645Cys ENST00000275493.6:c.1934C>G 7:g.55172997C>G EGFR ENST00000275493.6 3633 3236 2811952 2811952 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 31534501 pleural effusion NS 69 ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876608 2876608 2731123 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 133219841 c.2240T>A p.L747H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Confirmed somatic variant 29506987 circulating tumour NS ENSP00000415559.1:p.Leu747His ENST00000455089.5:c.2240T>A 7:g.55181384T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876610 2876610 2731125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832111 COSM6493934 133219841 c.2240T>A p.L747H Substitution - Missense 38 7:55181384-55181384 + Yes PATHOGENIC .92802 Confirmed somatic variant 29506987 circulating tumour NS 62 ENSP00000415559.1:p.Leu747His ENST00000455089.5:c.2240T>A 7:g.55181384T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-L9-A50W-01 2263346 2130330 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 417 NS primary 75 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920108 920108 837187 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51816100 COSM13430 132569804 c.2380G>A p.A794T Substitution - Missense hom 38 7:55191764-55191764 + - PATHOGENIC .98912 Confirmed somatic variant 15623594 surgery-fixed NS 59 ENSP00000395243.3:p.Ala794Thr ENST00000454757.6:c.2380G>A 7:g.55191764G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003955-T01-IM3 2719291 2578112 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51841887 COSM6949297 132565246 c.1819G>A p.G607R Substitution - Missense het 38 7:55173017-55173017 + - PATHOGENIC .99728 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly607Arg ENST00000454757.6:c.1819G>A 7:g.55173017G>A EGFR ENST00000275493.6 3633 3236 T3064 2296168 2161771 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51804131 COSM4680403 99388284 c.3610A>C p.S1204R Substitution - Missense 38 7:55205594-55205594 + - PATHOGENIC .82773 Confirmed somatic variant 25344691 NS NS 75.5 ENSP00000275493.2:p.Ser1204Arg ENST00000275493.6:c.3610A>C 7:g.55205594A>C EGFR ENST00000275493.6 3633 3236 2857072 2857072 2712372 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV105110417 COSM9522635 99415865 c.2506C>G p.R836G Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .96487 Confirmed somatic variant 31937902 surgery-fixed NS 17 ENSP00000275493.2:p.Arg836Gly ENST00000275493.6:c.2506C>G 7:g.55191755C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920017 920017 837096 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471541 1471541 1395280 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-86-8668-01 2194764 2063042 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 61 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 402 898388 816000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982857 982857 898576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982875 982875 898594 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001821-T01-IM3 2718057 2576878 soft_tissue smooth_muscle endometrium NS leiomyosarcoma NS NS NS n COSV51806557 COSM6919399 132588470 c.2660G>A p.R887H Substitution - Missense het 38 7:55198810-55198810 + - PATHOGENIC .99081 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Arg887His ENST00000454757.6:c.2660G>A 7:g.55198810G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 166 897193 814816 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1790521 1790521 1693500 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458699 1458699 1382674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SC-her2-051 2313868 2179064 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51850832 COSM4943273 133277300 c.705C>A p.N235K Substitution - Missense 38 7:55154103-55154103 + - PATHOGENIC .93631 Confirmed somatic variant 24185512 surgery fresh/frozen metastasis ENSP00000415559.1:p.Asn235Lys ENST00000455089.5:c.705C>A 7:g.55154103C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GCTK_424_T 2747457 2606160 stomach NS NS NS carcinoma NS NS NS y COSV99292647 COSM8533690 132567268 c.2282A>C p.K761T Substitution - Missense 38 7:55181426-55181426 + - PATHOGENIC .92579 Confirmed somatic variant 683 NS primary ENSP00000395243.3:p.Lys761Thr ENST00000454757.6:c.2282A>C 7:g.55181426A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003739-T01-IM5 2720227 2579048 soft_tissue blood_vessel skin NS angiosarcoma NS NS NS n COSV51783517 COSM3639743 132546885 c.1729C>T p.P577S Substitution - Missense het 38 7:55165421-55165421 + - NEUTRAL .20892 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Pro577Ser ENST00000454757.6:c.1729C>T 7:g.55165421C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002329-T01-IM3 2718615 2577436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1656173 1656173 1570830 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51772347 COSM17570 133206975 c.2087C>T p.P696L Substitution - Missense het 38 7:55174759-55174759 + - PATHOGENIC .9905 Confirmed somatic variant 21771097 surgery-fixed NS 64 ENSP00000415559.1:p.Pro696Leu ENST00000455089.5:c.2087C>T 7:g.55174759C>T EGFR ENST00000275493.6 3633 3236 B103-S1 2732514 2591270 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV104576423 COSM9498532 99382841 c.1701G>T p.M567I Substitution - Missense 38 7:55163802-55163802 + - PATHOGENIC .93931 Confirmed somatic variant 29244145 surgery fresh/frozen primary 74.3 ENSP00000275493.2:p.Met567Ile ENST00000275493.6:c.1701G>T 7:g.55163802G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-HT-8110-01 2194393 2062671 central_nervous_system brain NS NS glioma NS NS NS y COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 545 NS NS 57 ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EE-A2MI-06 2121680 1995916 skin NS NS NS malignant_melanoma NS NS NS y COSV51783517 COSM3639743 132546885 c.1729C>T p.P577S Substitution - Missense 38 7:55165421-55165421 + - NEUTRAL .20892 Confirmed somatic variant 540 NS NS 43 ENSP00000395243.3:p.Pro577Ser ENST00000454757.6:c.1729C>T 7:g.55165421C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-D7-6521-01 2198059 2066337 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51778897 COSM3881800 133260762 c.253G>A p.V85M Substitution - Missense 38 7:55143317-55143317 + - PATHOGENIC .99051 Confirmed somatic variant 541 NS NS 65 ENSP00000415559.1:p.Val85Met ENST00000455089.5:c.253G>A 7:g.55143317G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-2565-01 1337884 1248269 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772147 COSM375343 132564558 c.1799C>G p.S600C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000395243.3:p.Ser600Cys ENST00000454757.6:c.1799C>G 7:g.55172997C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LICA-CN-HCC131T 2634178 2494574 liver NS NS NS other neoplasm NS NS y COSV51799496 COSM5824594 133230058 c.244A>T p.I82F Substitution - Missense 38 7:55143308-55143308 + - PATHOGENIC .99415 Confirmed somatic variant 660 NS primary 49 ENSP00000415559.1:p.Ile82Phe ENST00000455089.5:c.244A>T 7:g.55143308A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_C30 1863711 1754602 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 22975805 surgery fresh/frozen primary 38 ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811952 2811952 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 132551897 c.2447T>G p.L816R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 31534501 pleural effusion NS 69 ENSP00000395243.3:p.Leu816Arg ENST00000454757.6:c.2447T>G 7:g.55191831T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-OX-A56R-01 2178260 2046558 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 68 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 P-0002489-T01-IM3 2718761 2577582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-2565-01 1337884 1248269 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005051-T01-IM5 2721455 2580276 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 TCGA-AA-3518-01 1650979 1565766 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51816226 COSM291680 99421703 c.2524A>C p.N842H Substitution - Missense 38 7:55191773-55191773 + - PATHOGENIC .98756 Confirmed somatic variant 22810696 376 NS NS 81 ENSP00000275493.2:p.Asn842His ENST00000275493.6:c.2524A>C 7:g.55191773A>C EGFR ENST00000275493.6 3633 3236 P-0005725-T01-IM5 2722109 2580930 NS NS NS NS malignant_melanoma NS NS NS n COSV51776559 COSM4892884 99381163 c.298C>T p.P100S Substitution - Missense het 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Pro100Ser ENST00000275493.6:c.298C>T 7:g.55143362C>T EGFR ENST00000275493.6 3633 3236 1091704 1091704 1006526 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM22420 178383004 c.? p.V843I Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS ENSP00000275493.2:p.Val843Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105111127 COSM9869918 133282247 c.2239C>G p.L747V Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .95352 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000415559.1:p.Leu747Val ENST00000455089.5:c.2239C>G 7:g.55181383C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 133206440 c.2113G>C p.A705P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000415559.1:p.Ala705Pro ENST00000455089.5:c.2113G>C 7:g.55174785G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 961769 961769 878053 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51865841 COSM14243 132612609 c.2099A>G p.K700R Substitution - Missense het 38 7:55174771-55174771 + - PATHOGENIC .99591 Confirmed somatic variant 16324836 fixed - NOS NS 72 ENSP00000395243.3:p.Lys700Arg ENST00000454757.6:c.2099A>G 7:g.55174771A>G EGFR ENST00000275493.6 3633 3236 TCGA-14-1455 2108036 1985897 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 99388542 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Thr363Ile ENST00000275493.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594190 1594190 1515164 upper_aerodigestive_tract pharynx oropharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 19726454 surgery fresh/frozen primary 70 ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD6112a 1480266 1403925 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51812104 COSM4384126 132581058 c.2413C>G p.H805D Substitution - Missense 38 7:55191797-55191797 + - PATHOGENIC .98487 Confirmed somatic variant 24030381 NS NS ENSP00000395243.3:p.His805Asp ENST00000454757.6:c.2413C>G 7:g.55191797C>G EGFR ENST00000275493.6 3633 3236 SC-her2-051 2313868 2179064 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51850832 COSM4943273 99453467 c.840C>A p.N280K Substitution - Missense 38 7:55154103-55154103 + - PATHOGENIC .93631 Confirmed somatic variant 24185512 surgery fresh/frozen metastasis ENSP00000275493.2:p.Asn280Lys ENST00000275493.6:c.840C>A 7:g.55154103C>A EGFR ENST00000275493.6 3633 3236 TCGA-12-0707-01 2178095 2046393 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 99378964 c.809A>G p.Y270C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 329 NS NS 55 ENSP00000275493.2:p.Tyr270Cys ENST00000275493.6:c.809A>G 7:g.55154072A>G EGFR ENST00000275493.6 3633 3236 P-0004117-T01-IM5 2720518 2579339 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense het 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876595 2876595 2731110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 133216269 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1472949 1472949 1396648 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51773206 COSM28603 132560955 c.2158G>A p.V720M Substitution - Missense 38 7:55181302-55181302 + - PATHOGENIC .97963 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000395243.3:p.Val720Met ENST00000454757.6:c.2158G>A 7:g.55181302G>A EGFR ENST00000275493.6 3633 3236 2901990 2901990 2756229 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005127-T01-IM5 2721532 2580353 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51794869 COSM4362780 133204758 c.439C>T p.P147S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Pro147Ser ENST00000455089.5:c.439C>T 7:g.55151308C>T EGFR ENST00000275493.6 3633 3236 TCGA-EE-A3AC-06 2121694 1995930 skin NS NS NS malignant_melanoma NS NS NS y COSV99295809 COSM7991924 99419179 c.2800C>A p.P934T Substitution - Missense 38 7:55198815-55198815 + - PATHOGENIC .96256 Confirmed somatic variant 540 NS NS 47 ENSP00000275493.2:p.Pro934Thr ENST00000275493.6:c.2800C>A 7:g.55198815C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-28-5207-01 2120332 1994568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 71 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 P-0001442-T02-IM5 2719422 2578243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 99396060 c.2281G>T p.D761Y Substitution - Missense het 38 7:55174818-55174818 + - PATHOGENIC .99554 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Asp761Tyr ENST00000275493.6:c.2281G>T 7:g.55174818G>T EGFR ENST00000275493.6 3633 3236 1040370 1040370 956947 central_nervous_system brain NS NS glioma oligoastrocytoma_Grade_III anaplastic NS n COSV51790148 COSM22555 99381470 c.2030G>A p.R677H Substitution - Missense 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000275493.2:p.Arg677His ENST00000275493.6:c.2030G>A 7:g.55173093G>A EGFR ENST00000275493.6 3633 3236 1040369 1040369 956946 central_nervous_system brain NS NS glioma oligoastrocytoma_Grade_III anaplastic NS n COSV51790148 COSM22555 99381470 c.2030G>A p.R677H Substitution - Missense 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000275493.2:p.Arg677His ENST00000275493.6:c.2030G>A 7:g.55173093G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000785-T01-IM3 2715984 2574805 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767730 COSM6548312 132554372 c.527G>T p.G176V Substitution - Missense het 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly176Val ENST00000454757.6:c.527G>T 7:g.55152579G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-A4-7583-01 2194049 2062327 kidney NS NS NS carcinoma papillary_renal_cell_carcinoma NS NS y COSV99289232 COSM8238800 132567926 c.3331C>A p.H1111N Substitution - Missense 38 7:55205450-55205450 + - NEUTRAL .21235 Confirmed somatic variant 543 NS NS 60 ENSP00000395243.3:p.His1111Asn ENST00000454757.6:c.3331C>A 7:g.55205450C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206723 1206723 1118601 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766928 COSM12718 133206642 c.2045A>G p.Y682C Substitution - Missense 38 7:55174039-55174039 + - PATHOGENIC .97626 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Tyr682Cys ENST00000455089.5:c.2045A>G 7:g.55174039A>G EGFR ENST00000275493.6 3633 3236 1589266 1589266 1510420 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51851529 COSM133149 99377960 c.2120T>C p.L707S Substitution - Missense 38 7:55173979-55173979 + - PATHOGENIC .97336 Confirmed somatic variant 22026926 surgery fresh/frozen NS ENSP00000275493.2:p.Leu707Ser ENST00000275493.6:c.2120T>C 7:g.55173979T>C EGFR ENST00000275493.6 3633 3236 2591495 2591495 2452455 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 P-0003108-T01-IM5 2829558 2685373 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51866279 COSM6926300 99378313 c.665G>A p.R222H Substitution - Missense 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 30205045 surgery-fixed metastasis 37 ENSP00000275493.2:p.Arg222His ENST00000275493.6:c.665G>A 7:g.55152582G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003393-T01-IM5 2829603 2685418 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51792310 COSM6928197 132554409 c.50C>T p.A17V Substitution - Missense 38 7:55019327-55019327 + - NEUTRAL .01177 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000395243.3:p.Ala17Val ENST00000454757.6:c.50C>T 7:g.55019327C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV104369002 COSM9233243 132578306 c.2095A>T p.I699F Substitution - Missense het 38 7:55174767-55174767 + - PATHOGENIC .99604 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000395243.3:p.Ile699Phe ENST00000454757.6:c.2095A>T 7:g.55174767A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LICA-CN-HCC131T 2634178 2494574 liver NS NS NS other neoplasm NS NS y COSV51799496 COSM5824594 132572208 c.244A>T p.I82F Substitution - Missense 38 7:55143308-55143308 + - PATHOGENIC .99415 Confirmed somatic variant 660 NS primary 49 ENSP00000395243.3:p.Ile82Phe ENST00000454757.6:c.244A>T 7:g.55143308A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 132550339 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000395243.3:p.Ala244Asp ENST00000454757.6:c.731C>A 7:g.55154129C>A EGFR ENST00000275493.6 3633 3236 2152758 2152758 2021768 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51836903 COSM3734670 99379420 c.2429G>C p.G810A Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98511 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Gly810Ala ENST00000275493.6:c.2429G>C 7:g.55181438G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004688-T01-IM5 2721089 2579910 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51824002 COSM6937752 133229963 c.2659C>T p.R887C Substitution - Missense het 38 7:55198809-55198809 + - PATHOGENIC .91422 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Arg887Cys ENST00000455089.5:c.2659C>T 7:g.55198809C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S06-38853-TP 2366573 2229456 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51796296 COSM4992967 133256102 c.1505G>A p.R502K Substitution - Missense het 38 7:55163741-55163741 + - PATHOGENIC .992 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000415559.1:p.Arg502Lys ENST00000455089.5:c.1505G>A 7:g.55163741G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DU-A5TT-01 2194423 2062701 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 70 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51770694 COSM20891 132562677 c.2251G>A p.G751S Substitution - Missense het 38 7:55181395-55181395 + - PATHOGENIC .98244 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000395243.3:p.Gly751Ser ENST00000454757.6:c.2251G>A 7:g.55181395G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002329-T01-IM3 2718615 2577436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004225-T01-IM5 2720632 2579453 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV51771772 COSM6934070 132621034 c.1164T>A p.H388Q Substitution - Missense het 38 7:55160139-55160139 + - PATHOGENIC .93122 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.His388Gln ENST00000454757.6:c.1164T>A 7:g.55160139T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DD-A73A-01 2194652 2062930 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51846765 COSM4916543 132554138 c.1097C>G p.P366R Substitution - Missense 38 7:55157687-55157687 + - PATHOGENIC .99735 Confirmed somatic variant 628 NS NS 71 ENSP00000395243.3:p.Pro366Arg ENST00000454757.6:c.1097C>G 7:g.55157687C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV104369001 COSM9233242 133238541 c.2011A>G p.K671E Substitution - Missense het 38 7:55174005-55174005 + - PATHOGENIC .95934 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000415559.1:p.Lys671Glu ENST00000455089.5:c.2011A>G 7:g.55174005A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001042-T01-IM3 2716511 2575332 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 2901985 2901985 2756228 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed metastasis 60 ENSP00000275493.2:p.Leu861Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PCSI_0590_Pa_P_526 2507081 2369417 pancreas NS NS NS carcinoma NS NS NS y COSV51771539 COSM5760860 133280290 c.1570A>G p.I524V Substitution - Missense 38 7:55163806-55163806 + - NEUTRAL .01956 Confirmed somatic variant 382 NS primary 73 ENSP00000415559.1:p.Ile524Val ENST00000455089.5:c.1570A>G 7:g.55163806A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007813-T01-IM5 2724038 2582859 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767730 COSM6548312 133209712 c.527G>T p.G176V Substitution - Missense het 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000415559.1:p.Gly176Val ENST00000455089.5:c.527G>T 7:g.55152579G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004944-T02-IM5 2721354 2580175 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843300 COSM6949613 133239979 c.802G>T p.A268S Substitution - Missense het 38 7:55155877-55155877 + - NEUTRAL .06397 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Ala268Ser ENST00000455089.5:c.802G>T 7:g.55155877G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 s_DS_scb_02_tumour 2861572 2716810 urinary_tract bladder NS NS carcinoma small_cell_carcinoma NS NS n COSV105109947 COSM9575249 133224077 c.538G>A p.G180S Substitution - Missense 38 7:55152590-55152590 + - PATHOGENIC .99676 Confirmed somatic variant 29180607 surgery-fixed NS 68 ENSP00000415559.1:p.Gly180Ser ENST00000455089.5:c.538G>A 7:g.55152590G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625889 2625889 2486301 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51800917 COSM6191460 132566346 c.1892A>G p.K631R Substitution - Missense 38 7:55173090-55173090 + - PATHOGENIC .99801 Confirmed somatic variant 25617745 surgery-fixed NS 47 ENSP00000395243.3:p.Lys631Arg ENST00000454757.6:c.1892A>G 7:g.55173090A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 YUKLAB 2013569 1896201 skin NS NS NS malignant_melanoma NS NS NS y COSV51796177 COSM1698689 132584382 c.1054A>T p.T352S Substitution - Missense het 38 7:55156814-55156814 + - PATHOGENIC .9893 Confirmed somatic variant 22842228 surgery fresh/frozen metastasis 84 ENSP00000395243.3:p.Thr352Ser ENST00000454757.6:c.1054A>T 7:g.55156814A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AA-3982-01 1651089 1565876 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51769747 COSM297803 132576756 c.772G>C p.D258H Substitution - Missense 38 7:55155847-55155847 + - PATHOGENIC .99461 Confirmed somatic variant 22810696 376 NS NS 75 ENSP00000395243.3:p.Asp258His ENST00000454757.6:c.772G>C 7:g.55155847G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812082 2812082 2668551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 132551512 c.2113G>C p.A705P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Confirmed somatic variant 31534501 pleural effusion NS 68 ENSP00000395243.3:p.Ala705Pro ENST00000454757.6:c.2113G>C 7:g.55174785G>C EGFR ENST00000275493.6 3633 3236 1022 2491916 2354545 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS y COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 26437033 surgery fresh/frozen NS 55 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 LC_C30 1863711 1754602 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 22975805 surgery fresh/frozen primary 38 ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 TG95755 2823143 2678997 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Confirmed somatic variant 28818608 surgery-fixed NS 63 ENSP00000275493.2:p.Leu861Gln EGFR ENST00000275493.6 3633 3236 P-0005511-T01-IM5 2721903 2580724 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51836402 COSM6944131 99396528 c.2354C>G p.T785S Substitution - Missense het 38 7:55181363-55181363 + - PATHOGENIC .951 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Thr785Ser ENST00000275493.6:c.2354C>G 7:g.55181363C>G EGFR ENST00000275493.6 3633 3236 CGCRC167 2434467 2297344 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV105863926 COSM10049280 99398932 c.2894T>A p.I965N Substitution - Missense 38 7:55200361-55200361 + - PATHOGENIC .96814 Confirmed somatic variant 26416732 surgery - NOS primary 81 ENSP00000275493.2:p.Ile965Asn ENST00000275493.6:c.2894T>A 7:g.55200361T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 WGC003608 2785119 2645235 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS y COSV99286188 COSM7420903 132595220 c.1435G>T p.V479F Substitution - Missense 38 7:55161570-55161570 + - .6767 Confirmed somatic variant 25526346 surgery fresh/frozen primary 54 ENSP00000395243.3:p.Val479Phe ENST00000454757.6:c.1435G>T 7:g.55161570G>T EGFR ENST00000275493.6 3633 3236 2811952 2811952 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 99378740 c.2582T>G p.L861R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 31534501 pleural effusion NS 69 ENSP00000275493.2:p.Leu861Arg ENST00000275493.6:c.2582T>G 7:g.55191831T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011029-T01-IM5 2726666 2585487 skin mucosal vagina NS malignant_melanoma NS NS NS n COSV51814016 COSM6978576 132555558 c.3113A>G p.D1038G Substitution - Missense het 38 7:55202602-55202602 + - PATHOGENIC .96122 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Asp1038Gly ENST00000454757.6:c.3113A>G 7:g.55202602A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CRC396 2730836 2589605 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV105863800 COSM10061888 132558337 c.1847C>G p.A616G Substitution - Missense 38 7:55173045-55173045 + - .53009 Confirmed somatic variant 26416732 xenograft metastasis 57 ENSP00000395243.3:p.Ala616Gly ENST00000454757.6:c.1847C>G 7:g.55173045C>G EGFR ENST00000275493.6 3633 3236 SJALL040461-R 2824036 2679864 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV104576718 COSM9280424 99388710 c.1592G>A p.R531Q Substitution - Missense 38 7:55161592-55161592 + - PATHOGENIC .99386 Confirmed somatic variant 31697823 blood-bone marrow recurrent 11.64 ENSP00000275493.2:p.Arg531Gln ENST00000275493.6:c.1592G>A 7:g.55161592G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-2567-01 1337886 1248271 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51816377 COSM3412194 99374959 c.1786C>T p.P596S Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99531 Confirmed somatic variant 329 surgery fresh/frozen NS 65 ENSP00000275493.2:p.Pro596Ser ENST00000275493.6:c.1786C>T 7:g.55165343C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 IGC-10-1053 2662337 2522461 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51767730 COSM6548312 132554372 c.527G>T p.G176V Substitution - Missense 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000395243.3:p.Gly176Val ENST00000454757.6:c.527G>T 7:g.55152579G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SJERG020309_D1 2565683 2427077 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51802051 COSM5986345 133245748 c.1858G>A p.G620S Substitution - Missense 38 7:55173056-55173056 + - PATHOGENIC .98464 Confirmed somatic variant 27776115 blood-bone marrow primary 17.5 ENSP00000415559.1:p.Gly620Ser ENST00000455089.5:c.1858G>A 7:g.55173056G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004400-T01-IM5 2720811 2579632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001506-T01-IM3 2717427 2576248 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51844502 COSM6917412 133231950 c.2597G>C p.G866A Substitution - Missense het 38 7:55198747-55198747 + - PATHOGENIC .99519 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly866Ala ENST00000455089.5:c.2597G>C 7:g.55198747G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-VS092-T1 2869925 2724922 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110023 COSM9807078 132555171 c.3271C>T p.P1091S Substitution - Missense 38 7:55205390-55205390 + - PATHOGENIC .97468 Confirmed somatic variant 26950094 surgery - NOS NS 77 ENSP00000395243.3:p.Pro1091Ser ENST00000454757.6:c.3271C>T 7:g.55205390C>T EGFR ENST00000275493.6 3633 3236 2901982 2901982 2756227 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008145-T01-IM5 2724309 2583130 breast NS NS NS carcinoma NS NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003116-T01-IM5 2719610 2578431 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51809537 COSM6926377 133218861 c.2906A>T p.D969V Substitution - Missense het 38 7:55201282-55201282 + - PATHOGENIC .99519 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Asp969Val ENST00000455089.5:c.2906A>T 7:g.55201282A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001262 1001262 918485 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1179547 1179547 1091509 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458689 1458689 1382664 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004794 1004794 922006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16140420 surgery - NOS primary 53 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-62-8394-01 2194776 2063054 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 65 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A114-T-S43 2757428 2616005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 61 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152767 2152767 2021777 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920032 920032 837111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense het 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 15623594 surgery fresh/frozen NS 76 ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CGCRC167 2434467 2297344 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV105863926 COSM10049280 133224199 c.2759T>A p.I920N Substitution - Missense 38 7:55200361-55200361 + - PATHOGENIC .96814 Confirmed somatic variant 26416732 surgery - NOS primary 81 ENSP00000415559.1:p.Ile920Asn ENST00000455089.5:c.2759T>A 7:g.55200361T>A EGFR ENST00000275493.6 3633 3236 2625912 2625912 2486324 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51840660 COSM6191463 99396021 c.3563A>C p.K1188T Substitution - Missense 38 7:55205547-55205547 + - PATHOGENIC .7653 Confirmed somatic variant 25617745 surgery-fixed NS 66 ENSP00000275493.2:p.Lys1188Thr ENST00000275493.6:c.3563A>C 7:g.55205547A>C EGFR ENST00000275493.6 3633 3236 TCGA-06-2557-01 1337877 1248262 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 76 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 1040384 1040384 956961 central_nervous_system brain NS NS glioma oligoastrocytoma NS NS n COSV51790148 COSM22555 99381470 c.2030G>A p.R677H Substitution - Missense 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000275493.2:p.Arg677His ENST00000275493.6:c.2030G>A 7:g.55173093G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005127-T01-IM5 2721532 2580353 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51802355 COSM6941144 132549822 c.1019C>T p.P340L Substitution - Missense het 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Pro340Leu ENST00000454757.6:c.1019C>T 7:g.55156779C>T EGFR ENST00000275493.6 3633 3236 P-0001328-T01-IM3 2717084 2575905 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51833335 COSM6916442 99391117 c.14G>C p.G5A Substitution - Missense het 38 7:55019291-55019291 + - NEUTRAL .0753 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly5Ala ENST00000275493.6:c.14G>C 7:g.55019291G>C EGFR ENST00000275493.6 3633 3236 TCGA-AM-5821-01 1651151 1565938 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV99291226 COSM7552389 99405137 c.1124C>T p.A375V Substitution - Missense 38 7:55156650-55156650 + - PATHOGENIC .98971 Confirmed somatic variant 376 NS NS 68 ENSP00000275493.2:p.Ala375Val ENST00000275493.6:c.1124C>T 7:g.55156650C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Br140X 1313029 1223938 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 xenograft primary 41 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1461 2602435 2463311 large_intestine right NS NS carcinoma adenocarcinoma NS NS n COSV51813913 COSM6023901 99382436 c.344A>C p.N115T Substitution - Missense 38 7:55143408-55143408 + - PATHOGENIC .92454 Confirmed somatic variant 27121310 surgery fresh/frozen NS 47 ENSP00000275493.2:p.Asn115Thr ENST00000275493.6:c.344A>C 7:g.55143408A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P147 2072600 1951955 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 44 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 Pat_01_B 2492838 2355452 NS NS NS NS malignant_melanoma NS NS NS y COSV51817615 COSM5872885 99406337 c.2789G>A p.G930E Substitution - Missense 38 7:55198804-55198804 + - PATHOGENIC .99081 Confirmed somatic variant 24265153 surgery-fixed NS 45 ENSP00000275493.2:p.Gly930Glu ENST00000275493.6:c.2789G>A 7:g.55198804G>A EGFR ENST00000275493.6 3633 3236 PCSI_0588_Pa_P_526 2507080 2369416 pancreas NS NS NS carcinoma NS NS NS y COSV51770777 COSM28286 99393107 c.2494C>T p.R832C Substitution - Missense 38 7:55191743-55191743 + - PATHOGENIC .95135 Confirmed somatic variant 382 NS primary 78 ENSP00000275493.2:p.Arg832Cys ENST00000275493.6:c.2494C>T 7:g.55191743C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005127-T01-IM5 2721532 2580353 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51794869 COSM4362780 132549800 c.439C>T p.P147S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Pro147Ser ENST00000454757.6:c.439C>T 7:g.55151308C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AA-3518-01 1650979 1565766 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51816226 COSM291680 133246367 c.2389A>C p.N797H Substitution - Missense 38 7:55191773-55191773 + - PATHOGENIC .98756 Confirmed somatic variant 22810696 376 NS NS 81 ENSP00000415559.1:p.Asn797His ENST00000455089.5:c.2389A>C 7:g.55191773A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-3650-01 2120284 1994520 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 46 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 P-0001821-T01-IM3 2718057 2576878 soft_tissue smooth_muscle endometrium NS leiomyosarcoma NS NS NS n COSV51806557 COSM6919399 99426383 c.2795G>A p.R932H Substitution - Missense het 38 7:55198810-55198810 + - PATHOGENIC .99081 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Arg932His ENST00000275493.6:c.2795G>A 7:g.55198810G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1179542 1179542 1091504 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51768413 COSM25861 133254868 c.2139A>C p.E713D Substitution - Missense het 38 7:55174811-55174811 + - PATHOGENIC .88475 Confirmed somatic variant 18985444 surgery - NOS primary 72 ENSP00000415559.1:p.Glu713Asp ENST00000455089.5:c.2139A>C 7:g.55174811A>C EGFR ENST00000275493.6 3633 3236 PCA1587 2861424 2716668 prostate NS NS NS carcinoma NS NS NS n COSV105111148 COSM9581094 99449171 c.2020G>T p.V674F Substitution - Missense 38 7:55173083-55173083 + - PATHOGENIC .97182 Confirmed somatic variant 32268276 circulating tumour NS ENSP00000275493.2:p.Val674Phe ENST00000275493.6:c.2020G>T 7:g.55173083G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-14-0786-01 1337986 1248371 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2150407 2150407 2019476 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 P-0004688-T01-IM5 2721089 2579910 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51824002 COSM6937752 99404206 c.2794C>T p.R932C Substitution - Missense het 38 7:55198809-55198809 + - PATHOGENIC .91422 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Arg932Cys ENST00000275493.6:c.2794C>T 7:g.55198809C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002489-T01-IM3 2718761 2577582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 P-0009459-T01-IM5 2725386 2584207 testis NS NS NS germ_cell_tumour mixed NS NS n COSV51822613 COSM6968786 99388474 c.92G>T p.C31F Substitution - Missense het 38 7:55142289-55142289 + - PATHOGENIC .99814 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Cys31Phe ENST00000275493.6:c.92G>T 7:g.55142289G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-2557-01 1337877 1248262 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 76 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 60 2699441 2558345 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51859123 COSM6906662 132574652 c.1903C>T p.R635W Substitution - Missense het 38 7:55173101-55173101 + - PATHOGENIC .98228 Confirmed somatic variant 29420467 surgery-fixed NS ENSP00000395243.3:p.Arg635Trp ENST00000454757.6:c.1903C>T 7:g.55173101C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811972 2811972 2668500 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 31534501 surgery-fixed metastasis 64 ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003316-T01-IM5 2719809 2578630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 TCGA-EE-A2MR-06 2121688 1995924 skin NS NS NS malignant_melanoma NS NS NS y COSV51788720 COSM3639737 99433957 c.1534C>T p.P512S Substitution - Missense 38 7:55161534-55161534 + - NEUTRAL .03494 Confirmed somatic variant 540 NS NS 61 ENSP00000275493.2:p.Pro512Ser ENST00000275493.6:c.1534C>T 7:g.55161534C>T EGFR ENST00000275493.6 3633 3236 P-0001914-T01-IM3 2718230 2577051 central_nervous_system brain NS NS glioma astrocytoma NS NS n COSV51779794 COSM53264 99387824 c.2174C>T p.T725M Substitution - Missense het 38 7:55174033-55174033 + - PATHOGENIC .97744 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr725Met ENST00000275493.6:c.2174C>T 7:g.55174033C>T EGFR ENST00000275493.6 3633 3236 2755733 2755733 2614426 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM1166943 178385114 c.? p.V769L Substitution - Missense + - Confirmed somatic variant 29935845 surgery - NOS metastasis 68 ENSP00000275493.2:p.Val769Leu EGFR ENST00000275493.6 3633 3236 P-0006441-T01-IM5 2722817 2581638 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51775191 COSM1451530 99377057 c.187G>A p.G63R Substitution - Missense het 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly63Arg ENST00000275493.6:c.187G>A 7:g.55142384G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812086 2812086 2668553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51823614 COSM4170219 133202511 c.2120C>T p.S707F Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98332 Confirmed somatic variant 31534501 pleural effusion NS 76 ENSP00000415559.1:p.Ser707Phe ENST00000455089.5:c.2120C>T 7:g.55174792C>T EGFR ENST00000275493.6 3633 3236 IGC-03-1030 2662287 2522411 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51787961 COSM6530131 99407659 c.1895G>C p.G632A Substitution - Missense 38 7:55171189-55171189 + - PATHOGENIC .98448 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000275493.2:p.Gly632Ala ENST00000275493.6:c.1895G>C 7:g.55171189G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2014_Lung_sq_82_T 2744953 2603656 lung NS NS NS carcinoma NS NS NS y COSV51818649 COSM7238502 133262042 c.1227G>T p.K409N Substitution - Missense 38 7:55160202-55160202 + - PATHOGENIC .92978 Confirmed somatic variant 583 NS primary 62 ENSP00000415559.1:p.Lys409Asn ENST00000455089.5:c.1227G>T 7:g.55160202G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD42110c 2894819 2749307 skin extremity NS NS malignant_melanoma nodular NS NS y COSV105111084 COSM9905470 132578520 c.1885G>A p.V629I Substitution - Missense 38 7:55173083-55173083 + - PATHOGENIC .9014 Confirmed somatic variant 33024263 surgery-fixed metastasis ENSP00000395243.3:p.Val629Ile ENST00000454757.6:c.1885G>A 7:g.55173083G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1022 2491916 2354545 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS y COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 26437033 surgery fresh/frozen NS 55 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-14-1455 2108036 1985897 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 132560457 c.953C>T p.T318I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Thr318Ile ENST00000454757.6:c.953C>T 7:g.55156614C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920032 920032 837111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense het 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 15623594 surgery fresh/frozen NS 76 ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010967-T01-IM5 2726608 2585429 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51856949 COSM6978220 132613043 c.413G>T p.R138I Substitution - Missense het 38 7:55143477-55143477 + - PATHOGENIC .94211 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg138Ile ENST00000454757.6:c.413G>T 7:g.55143477G>T EGFR ENST00000275493.6 3633 3236 1206723 1206723 1118601 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51766928 COSM12718 99378527 c.2180A>G p.Y727C Substitution - Missense 38 7:55174039-55174039 + - PATHOGENIC .97626 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Tyr727Cys ENST00000275493.6:c.2180A>G 7:g.55174039A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD6780a 1503990 1426868 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia_with_ringed_sideroblasts NS n COSV51791654 COSM4384111 132581541 c.95A>G p.Q32R Substitution - Missense 38 7:55142292-55142292 + - PATHOGENIC .96882 Confirmed somatic variant 24030381 NS NS ENSP00000395243.3:p.Gln32Arg ENST00000454757.6:c.95A>G 7:g.55142292A>G EGFR ENST00000275493.6 3633 3236 2150407 2150407 2019476 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451155 1451155 1375298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005059-T01-IM5 2721463 2580284 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001328-T01-IM3 2717084 2575905 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211140 1211140 1123008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 54 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003393-T01-IM5 2719877 2578698 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51792310 COSM6928197 132554409 c.50C>T p.A17V Substitution - Missense het 38 7:55019327-55019327 + - NEUTRAL .01177 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ala17Val ENST00000454757.6:c.50C>T 7:g.55019327C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001328-T01-IM3 2717084 2575905 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51833335 COSM6916442 133218763 c.14G>C p.G5A Substitution - Missense het 38 7:55019291-55019291 + - NEUTRAL .0753 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly5Ala ENST00000455089.5:c.14G>C 7:g.55019291G>C EGFR ENST00000275493.6 3633 3236 1468628 1468628 1392379 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S0377 897601 815224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 15118125 surgery - NOS primary ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-D1-A2G5-01 2198276 2066554 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99295137 COSM8817249 132582272 c.1738A>G p.T580A Substitution - Missense 38 7:55165430-55165430 + - PATHOGENIC .99619 Confirmed somatic variant 419 NS NS 50 ENSP00000395243.3:p.Thr580Ala ENST00000454757.6:c.1738A>G 7:g.55165430A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009459-T01-IM5 2725386 2584207 testis NS NS NS germ_cell_tumour mixed NS NS n COSV51822613 COSM6968786 132560408 c.92G>T p.C31F Substitution - Missense het 38 7:55142289-55142289 + - PATHOGENIC .99814 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Cys31Phe ENST00000454757.6:c.92G>T 7:g.55142289G>T EGFR ENST00000275493.6 3633 3236 14_S4 2902121 2756359 autonomic_ganglia NS NS NS neuroblastoma NS NS NS n COSV105863896 COSM9976114 99396376 c.818C>G p.T273S Substitution - Missense 38 7:55154081-55154081 + - PATHOGENIC .94747 Confirmed somatic variant 33381456 circulating tumour primary 7 ENSP00000275493.2:p.Thr273Ser ENST00000275493.6:c.818C>G 7:g.55154081C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005585-T01-IM5 2721978 2580799 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51837327 COSM6944624 133202746 c.2856C>G p.F952L Substitution - Missense het 38 7:55201232-55201232 + - NEUTRAL .42217 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Phe952Leu ENST00000455089.5:c.2856C>G 7:g.55201232C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 132562107 c.1256C>T p.S419L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000395243.3:p.Ser419Leu ENST00000454757.6:c.1256C>T 7:g.55160231C>T EGFR ENST00000275493.6 3633 3236 P-0004688-T01-IM5 2721089 2579910 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51823965 COSM6937748 99404185 c.76G>A p.E26K Substitution - Missense het 38 7:55019353-55019353 + - PATHOGENIC .70393 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Glu26Lys ENST00000275493.6:c.76G>A 7:g.55019353G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876611 2876611 2731126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105110312 COSM9869917 133238641 c.2017C>G p.L673V Substitution - Missense 38 7:55174011-55174011 + Yes PATHOGENIC .92276 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000415559.1:p.Leu673Val ENST00000455089.5:c.2017C>G 7:g.55174011C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008476-T01-IM5 2724590 2583411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 P-0010754-T01-IM5 2787068 2644491 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51805749 COSM6976991 99375210 c.2644G>A p.A882T Substitution - Missense 38 7:55192784-55192784 + - PATHOGENIC .95513 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000275493.2:p.Ala882Thr ENST00000275493.6:c.2644G>A 7:g.55192784G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105110312 COSM9869917 133238641 c.2017C>G p.L673V Substitution - Missense 38 7:55174011-55174011 + Yes PATHOGENIC .92276 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000415559.1:p.Leu673Val ENST00000455089.5:c.2017C>G 7:g.55174011C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD42101a 2894816 2749304 skin trunk NS NS malignant_melanoma superficial_spreading NS NS y COSV51793030 COSM133566 133238435 c.2372G>A p.R791H Substitution - Missense 38 7:55191756-55191756 + - PATHOGENIC .98912 Confirmed somatic variant 33024263 surgery-fixed metastasis ENSP00000415559.1:p.Arg791His ENST00000455089.5:c.2372G>A 7:g.55191756G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008927-T01-IM5 2724943 2583764 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51768139 COSM21685 132550339 c.731C>A p.A244D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Asp ENST00000454757.6:c.731C>A 7:g.55154129C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001442-T02-IM5 2719422 2578243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 133222251 c.2146G>T p.D716Y Substitution - Missense het 38 7:55174818-55174818 + - PATHOGENIC .99554 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Asp716Tyr ENST00000455089.5:c.2146G>T 7:g.55174818G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AX-A06F-01 2198328 2066606 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51827490 COSM39163 132566663 c.1772G>A p.C591Y Substitution - Missense 38 7:55171201-55171201 + - PATHOGENIC .98251 Confirmed somatic variant 419 NS NS 59 ENSP00000395243.3:p.Cys591Tyr ENST00000454757.6:c.1772G>A 7:g.55171201G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005378-T01-IM5 2721782 2580603 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51862161 COSM6943352 132547184 c.73C>G p.L25V Substitution - Missense het 38 7:55019350-55019350 + - NEUTRAL .21138 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Leu25Val ENST00000454757.6:c.73C>G 7:g.55019350C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SJALL040461-R 2824036 2679864 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV104576718 COSM9280424 132560587 c.1457G>A p.R486Q Substitution - Missense 38 7:55161592-55161592 + - PATHOGENIC .99386 Confirmed somatic variant 31697823 blood-bone marrow recurrent 11.64 ENSP00000395243.3:p.Arg486Gln ENST00000454757.6:c.1457G>A 7:g.55161592G>A EGFR ENST00000275493.6 3633 3236 7C 2549418 2410873 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51792433 COSM6966446 99410412 c.1762G>A p.G588S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 646 NS primary 66 ENSP00000275493.2:p.Gly588Ser ENST00000275493.6:c.1762G>A 7:g.55165319G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 R074-R1 2813496 2669888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99297135 COSM9212199 132566217 c.730G>T p.A244S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 41 ENSP00000395243.3:p.Ala244Ser ENST00000454757.6:c.730G>T 7:g.55154128G>T EGFR ENST00000275493.6 3633 3236 2665865 2665865 2525573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM6842524 178391281 c.? p.V159E Substitution - Missense + - Confirmed somatic variant 28979142 surgery - NOS NS EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51776247 COSM6110417 132563707 c.1258G>A p.G420R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000395243.3:p.Gly420Arg ENST00000454757.6:c.1258G>A 7:g.55160233G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SJALL040461-R 2824036 2679864 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV104576718 COSM9280424 133216650 c.1457G>A p.R486Q Substitution - Missense 38 7:55161592-55161592 + - PATHOGENIC .99386 Confirmed somatic variant 31697823 blood-bone marrow recurrent 11.64 ENSP00000415559.1:p.Arg486Gln ENST00000455089.5:c.1457G>A 7:g.55161592G>A EGFR ENST00000275493.6 3633 3236 1656173 1656173 1570830 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51772347 COSM17570 99378871 c.2222C>T p.P741L Substitution - Missense het 38 7:55174759-55174759 + - PATHOGENIC .9905 Confirmed somatic variant 21771097 surgery-fixed NS 64 ENSP00000275493.2:p.Pro741Leu ENST00000275493.6:c.2222C>T 7:g.55174759C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-76-6282-01 2120389 1994625 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51810174 COSM3412190 133210629 c.1577G>C p.C526S Substitution - Missense 38 7:55163813-55163813 + - PATHOGENIC .99637 Confirmed somatic variant 329 NS NS 63 ENSP00000415559.1:p.Cys526Ser ENST00000455089.5:c.1577G>C 7:g.55163813G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001262 1001262 918485 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CHG-2015-31289T 2634363 2494759 liver NS NS NS other neoplasm NS NS y COSV51783393 COSM6237886 133205110 c.2340G>T p.M780I Substitution - Missense 38 7:55191724-55191724 + - PATHOGENIC .9903 Confirmed somatic variant 660 NS primary 45 ENSP00000415559.1:p.Met780Ile ENST00000455089.5:c.2340G>T 7:g.55191724G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CHC1774T 2340683 2205666 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51807517 COSM4802395 132590361 c.67C>T p.R23W Substitution - Missense 38 7:55019344-55019344 + - NEUTRAL .00803 Confirmed somatic variant 381 NS primary 65 ENSP00000395243.3:p.Arg23Trp ENST00000454757.6:c.67C>T 7:g.55019344C>T EGFR ENST00000275493.6 3633 3236 TCGA-12-3650-01 2120284 1994520 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 46 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV104369002 COSM9233243 99412112 c.2230A>T p.I744F Substitution - Missense het 38 7:55174767-55174767 + - PATHOGENIC .99604 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000275493.2:p.Ile744Phe ENST00000275493.6:c.2230A>T 7:g.55174767A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 007 2640411 2500713 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS y COSV51815598 COSM6471954 132564281 c.1190G>T p.S397I Substitution - Missense 38 7:55160165-55160165 + - NEUTRAL .44157 Confirmed somatic variant 27545006 fixed - NOS NS 57 ENSP00000395243.3:p.Ser397Ile ENST00000454757.6:c.1190G>T 7:g.55160165G>T EGFR ENST00000275493.6 3633 3236 P-0006863-T01-IM5 2723243 2582064 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51788393 COSM13979 99391974 c.2170G>A p.G724S Substitution - Missense het 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly724Ser ENST00000275493.6:c.2170G>A 7:g.55174029G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812133 2812133 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 circulating tumour NS 77 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-B5-A11E-01 1783399 1687398 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99287802 COSM9037443 99433727 c.529T>C p.S177P Substitution - Missense 38 7:55146710-55146710 + - NEUTRAL .17589 Confirmed somatic variant 419 fresh/frozen - NOS primary 53 ENSP00000275493.2:p.Ser177Pro ENST00000275493.6:c.529T>C 7:g.55146710T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-14-1455-01 2178074 2046372 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 133216524 c.953C>T p.T318I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 NS NS 61 ENSP00000415559.1:p.Thr318Ile ENST00000455089.5:c.953C>T 7:g.55156614C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876049 2876049 2730564 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 44 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876611 2876611 2731126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1471549 1471549 1395288 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2246145 2246145 2113419 lung left_lower_lobe NS NS carcinoma acinar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25176975 surgery - NOS primary 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1005003 1005003 922215 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920106 920106 837185 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery-fixed NS 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2812000 2812000 2668509 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471535 1471535 1395274 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1004993 1004993 922205 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471545 1471545 1395284 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1044285 1044285 960626 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-97-A4M1-01 2385678 2248510 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS primary 52 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006960-T01-IM5 2723335 2582156 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51767379 COSM85894 132557468 c.2392G>A p.V798I Substitution - Missense het 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Val798Ile ENST00000454757.6:c.2392G>A 7:g.55191776G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005016 1005016 922228 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 P-0001506-T01-IM3 2717427 2576248 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51844502 COSM6917412 99405883 c.2732G>C p.G911A Substitution - Missense het 38 7:55198747-55198747 + - PATHOGENIC .99519 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly911Ala ENST00000275493.6:c.2732G>C 7:g.55198747G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211130 1211130 1122998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen metastasis 59 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876652 2876652 2731167 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 67 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-14-1829-01 1338016 1248401 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 133216524 c.953C>T p.T318I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 surgery fresh/frozen NS 57 ENSP00000415559.1:p.Thr318Ile ENST00000455089.5:c.953C>T 7:g.55156614C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008476-T01-IM5 2724590 2583411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458683 1458683 1382658 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471544 1471544 1395283 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152777 2152777 2021787 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002534-T01-IM3 2718800 2577621 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876652 2876652 2731167 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982884 982884 898603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001123-T02-IM5 2719395 2578216 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920032 920032 837111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 76 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458679 1458679 1382654 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A001-T-S03 2757356 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876659 2876659 2731174 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001252 1001252 918475 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001296-T01-IM3 2717010 2575831 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007322-T01-IM5 2723661 2582482 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004810 1004810 922022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16140420 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007901-T01-IM5 2724112 2582933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 s_DS_scb_02_tumour 2861572 2716810 urinary_tract bladder NS NS carcinoma small_cell_carcinoma NS NS n COSV105109947 COSM9575249 99398758 c.673G>A p.G225S Substitution - Missense 38 7:55152590-55152590 + - PATHOGENIC .99676 Confirmed somatic variant 29180607 surgery-fixed NS 68 ENSP00000275493.2:p.Gly225Ser ENST00000275493.6:c.673G>A 7:g.55152590G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008476-T01-IM5 2724590 2583411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982883 982883 898602 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011038-T01-IM5 2726676 2585497 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001328-T01-IM3 2717084 2575905 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471554 1471554 1395293 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211140 1211140 1123008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A014-T-S52 2758140 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PCA1587 2861424 2716668 prostate NS NS NS carcinoma NS NS NS n COSV105111148 COSM9581094 133272306 c.1885G>T p.V629F Substitution - Missense 38 7:55173083-55173083 + - PATHOGENIC .97182 Confirmed somatic variant 32268276 circulating tumour NS ENSP00000415559.1:p.Val629Phe ENST00000455089.5:c.1885G>T 7:g.55173083G>T EGFR ENST00000275493.6 3633 3236 P-0006714-T01-IM5 2723094 2581915 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51834490 COSM6953161 99431522 c.2629C>G p.P877A Substitution - Missense het 38 7:55192769-55192769 + - PATHOGENIC .95807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Pro877Ala ENST00000275493.6:c.2629C>G 7:g.55192769C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007994-T01-IM5 2724178 2582999 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51811471 COSM6960839 132582539 c.380C>A p.A127E Substitution - Missense het 38 7:55143444-55143444 + - NEUTRAL .44126 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ala127Glu ENST00000454757.6:c.380C>A 7:g.55143444C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-28-1757-01 2178083 2046381 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 71 ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 2755733 2755733 2614426 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM18486 178378420 c.? p.S768I Substitution - Missense + - Confirmed somatic variant 29935845 surgery - NOS metastasis 68 ENSP00000275493.2:p.Ser768Ile EGFR ENST00000275493.6 3633 3236 2812133 2812133 2668576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 circulating tumour NS 77 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-DU-7006-01 2194244 2062522 central_nervous_system brain NS NS glioma NS NS NS y COSV51800797 COSM3412178 99385042 c.755G>C p.R252P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 545 NS NS 60 ENSP00000275493.2:p.Arg252Pro ENST00000275493.6:c.755G>C 7:g.55154018G>C EGFR ENST00000275493.6 3633 3236 1468633 1468633 1392384 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1312384 1312384 1223293 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2115513 2115513 1989757 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1140654 1140654 1053102 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM27625 178391749 c.? p.V717A Substitution - Missense + - Confirmed somatic variant 19238633 surgery-fixed metastasis 68 ENSP00000275493.2:p.Val717Ala EGFR ENST00000275493.6 3633 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 99377226 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000275493.2:p.Ala289Asp ENST00000275493.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011029-T01-IM5 2726666 2585487 skin mucosal vagina NS malignant_melanoma NS NS NS n COSV51814016 COSM6978576 133211427 c.3113A>G p.D1038G Substitution - Missense het 38 7:55202602-55202602 + - PATHOGENIC .96122 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Asp1038Gly ENST00000455089.5:c.3113A>G 7:g.55202602A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A014-T-S47 2758139 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471558 1471558 1395297 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Pat_28_B 2513795 2376164 NS NS NS NS malignant_melanoma NS NS NS y COSV51792098 COSM5872886 132554316 c.3224G>A p.S1075N Substitution - Missense 38 7:55205343-55205343 + - NEUTRAL .13132 Confirmed somatic variant 24265153 surgery-fixed NS 58 ENSP00000395243.3:p.Ser1075Asn ENST00000454757.6:c.3224G>A 7:g.55205343G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 J80_T 2194988 2063266 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51805367 COSM3950642 133234090 c.904G>A p.D302N Substitution - Missense 38 7:55156565-55156565 + - PATHOGENIC .82248 Confirmed somatic variant 583 NS NS ENSP00000415559.1:p.Asp302Asn ENST00000455089.5:c.904G>A 7:g.55156565G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920018 920018 837097 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876654 2876654 2731169 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 63 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 42 897188 814811 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152761 2152761 2021771 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460154 1460154 1384031 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489254 1489254 1412412 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152768 2152768 2021778 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010836-T01-IM5 2726504 2585325 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0005127-T01-IM5 2721532 2580353 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51802355 COSM6941144 99376606 c.1154C>T p.P385L Substitution - Missense het 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Pro385Leu ENST00000275493.6:c.1154C>T 7:g.55156779C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008927-T01-IM5 2724943 2583764 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51767495 COSM35752 132553689 c.619C>T p.R207C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg207Cys ENST00000454757.6:c.619C>T 7:g.55154017C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003739-T01-IM5 2720227 2579048 soft_tissue blood_vessel skin NS angiosarcoma NS NS NS n COSV51783517 COSM3639743 133202037 c.1729C>T p.P577S Substitution - Missense het 38 7:55165421-55165421 + - NEUTRAL .20892 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Pro577Ser ENST00000455089.5:c.1729C>T 7:g.55165421C>T EGFR ENST00000275493.6 3633 3236 P-0011029-T01-IM5 2726666 2585487 skin mucosal vagina NS malignant_melanoma NS NS NS n COSV51814016 COSM6978576 99382835 c.3248A>G p.D1083G Substitution - Missense het 38 7:55202602-55202602 + - PATHOGENIC .96122 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Asp1083Gly ENST00000275493.6:c.3248A>G 7:g.55202602A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-EE-A2MI-06 2121680 1995916 skin NS NS NS malignant_melanoma NS NS NS y COSV51783517 COSM3639743 133202037 c.1729C>T p.P577S Substitution - Missense 38 7:55165421-55165421 + - NEUTRAL .20892 Confirmed somatic variant 540 NS NS 43 ENSP00000415559.1:p.Pro577Ser ENST00000455089.5:c.1729C>T 7:g.55165421C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005127-T01-IM5 2721532 2580353 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51800313 COSM5608354 133204795 c.2137G>A p.E713K Substitution - Missense het 38 7:55174809-55174809 + - PATHOGENIC .99476 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Glu713Lys ENST00000455089.5:c.2137G>A 7:g.55174809G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003175-T01-IM5 2719668 2578489 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51836358 COSM6926707 132621269 c.1923G>C p.R641S Substitution - Missense het 38 7:55173121-55173121 + - PATHOGENIC .86375 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Arg641Ser ENST00000454757.6:c.1923G>C 7:g.55173121G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AA-3966-01 1651077 1565864 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51801471 COSM53105 133208181 c.2357G>A p.R786H Substitution - Missense 38 7:55191741-55191741 + - PATHOGENIC .96289 Confirmed somatic variant 22810696 376 NS NS 89 ENSP00000415559.1:p.Arg786His ENST00000455089.5:c.2357G>A 7:g.55191741G>A EGFR ENST00000275493.6 3633 3236 P-0002999-T01-IM3 2719208 2578029 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 99382805 c.755G>A p.R252H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg252His ENST00000275493.6:c.755G>A 7:g.55154018G>A EGFR ENST00000275493.6 3633 3236 P-0003693-T02-IM5 2720181 2579002 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51805704 COSM6930161 99378196 c.3372C>G p.H1124Q Substitution - Missense het 38 7:55205356-55205356 + - NEUTRAL .41128 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.His1124Gln ENST00000275493.6:c.3372C>G 7:g.55205356C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1589266 1589266 1510420 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51851529 COSM133149 133206047 c.1985T>C p.L662S Substitution - Missense 38 7:55173979-55173979 + - PATHOGENIC .97336 Confirmed somatic variant 22026926 surgery fresh/frozen NS ENSP00000415559.1:p.Leu662Ser ENST00000455089.5:c.1985T>C 7:g.55173979T>C EGFR ENST00000275493.6 3633 3236 TCGA-14-0786-01 1337986 1248371 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 PD8934a 1595624 1516507 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51847987 COSM4384128 99386272 c.2866G>A p.D956N Substitution - Missense 38 7:55200333-55200333 + - PATHOGENIC .99504 Confirmed somatic variant 24030381 NS NS ENSP00000275493.2:p.Asp956Asn ENST00000275493.6:c.2866G>A 7:g.55200333G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD24225a 2234144 2101649 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV51817351 COSM3881830 132566658 c.2957G>A p.R986Q Substitution - Missense 38 7:55201333-55201333 + - PATHOGENIC .98371 Confirmed somatic variant 652 NS NS ENSP00000395243.3:p.Arg986Gln ENST00000454757.6:c.2957G>A 7:g.55201333G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-EE-A3AC-06 2121694 1995930 skin NS NS NS malignant_melanoma NS NS NS y COSV99295809 COSM7991924 133244278 c.2665C>A p.P889T Substitution - Missense 38 7:55198815-55198815 + - PATHOGENIC .96256 Confirmed somatic variant 540 NS NS 47 ENSP00000415559.1:p.Pro889Thr ENST00000455089.5:c.2665C>A 7:g.55198815C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV104369003 COSM9233187 133238555 c.2161A>T p.M721L Substitution - Missense het 38 7:55181305-55181305 + - PATHOGENIC .98406 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000415559.1:p.Met721Leu ENST00000455089.5:c.2161A>T 7:g.55181305A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T1748 2658268 2518427 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51796395 COSM6652238 133261886 c.1109C>T p.T370M Substitution - Missense 38 7:55157699-55157699 + - PATHOGENIC .97374 Confirmed somatic variant 27149842 NS NS 85.08 ENSP00000415559.1:p.Thr370Met ENST00000455089.5:c.1109C>T 7:g.55157699C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006622-T01-IM5 2829996 2685811 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51845994 COSM5530405 132547619 c.1498G>A p.E500K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 30205045 surgery-fixed primary 43 ENSP00000395243.3:p.Glu500Lys ENST00000454757.6:c.1498G>A 7:g.55163734G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S10-24679-TP 2366580 2229463 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51808100 COSM4992964 132606086 c.683C>T p.T228I Substitution - Missense het 38 7:55154081-55154081 + - PATHOGENIC .9224 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000395243.3:p.Thr228Ile ENST00000454757.6:c.683C>T 7:g.55154081C>T EGFR ENST00000275493.6 3633 3236 T1748 2658268 2518427 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51796395 COSM6652238 99438958 c.1244C>T p.T415M Substitution - Missense 38 7:55157699-55157699 + - PATHOGENIC .97374 Confirmed somatic variant 27149842 NS NS 85.08 ENSP00000275493.2:p.Thr415Met ENST00000275493.6:c.1244C>T 7:g.55157699C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577026 COSM9413136 132621873 c.1258G>C p.G420R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .4176 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000395243.3:p.Gly420Arg ENST00000454757.6:c.1258G>C 7:g.55160233G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S001071 1027700 944676 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 P-0003955-T01-IM3 2719291 2578112 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51841887 COSM6949297 99395129 c.1954G>A p.G652R Substitution - Missense het 38 7:55173017-55173017 + - PATHOGENIC .99728 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly652Arg ENST00000275493.6:c.1954G>A 7:g.55173017G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1165892 1165892 1078206 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51785733 COSM28575 133235090 c.2515G>A p.E839K Substitution - Missense het 38 7:55192790-55192790 + - PATHOGENIC .9655 Confirmed somatic variant 16407879 surgery - NOS metastasis 70 ENSP00000415559.1:p.Glu839Lys ENST00000455089.5:c.2515G>A 7:g.55192790G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EE-A17X-06 2121618 1995854 skin NS NS NS malignant_melanoma NS NS NS y COSV51781835 COSM174732 132552286 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 540 NS NS 54 ENSP00000395243.3:p.Glu114Lys ENST00000454757.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002659-T01-IM3 2718905 2577726 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51775381 COSM6923532 133251948 c.914C>G p.S305C Substitution - Missense het 38 7:55156575-55156575 + - PATHOGENIC .99062 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ser305Cys ENST00000455089.5:c.914C>G 7:g.55156575C>G EGFR ENST00000275493.6 3633 3236 P-0001328-T01-IM3 2717084 2575905 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 P-0008476-T01-IM5 2724590 2583411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001042-T01-IM3 2716511 2575332 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51787557 COSM6191456 132549765 c.1202C>T p.T401I Substitution - Missense het 38 7:55160177-55160177 + - NEUTRAL .13103 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr401Ile ENST00000454757.6:c.1202C>T 7:g.55160177C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-A6S1-01 2263260 2130244 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS primary 53 ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982889 982889 898608 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982888 982888 898607 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003891-T01-IM5 2720383 2579204 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51822575 COSM6932208 133216451 c.2639C>T p.S880F Substitution - Missense het 38 7:55198789-55198789 + - NEUTRAL .37023 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ser880Phe ENST00000455089.5:c.2639C>T 7:g.55198789C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982791 982791 898510 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51779524 COSM18425 132552477 c.2021G>A p.G674D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Asp ENST00000454757.6:c.2021G>A 7:g.55174015G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51774667 COSM53194 133211250 c.2062C>T p.P688S Substitution - Missense het 38 7:55174734-55174734 + - PATHOGENIC .99806 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000415559.1:p.Pro688Ser ENST00000455089.5:c.2062C>T 7:g.55174734C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 XHDG25C 2321255 2186409 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV51811244 COSM4767521 132551866 c.472G>A p.G158R Substitution - Missense 38 7:55151341-55151341 + - PATHOGENIC .99471 Confirmed somatic variant 24997986 NS NS 77 ENSP00000395243.3:p.Gly158Arg ENST00000454757.6:c.472G>A 7:g.55151341G>A EGFR ENST00000275493.6 3633 3236 2876595 2876595 2731110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 99388191 c.2389T>A p.C797S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2389T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006960-T01-IM5 2723335 2582156 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51787507 COSM13188 132557864 c.2146G>A p.D716N Substitution - Missense het 38 7:55174818-55174818 + - PATHOGENIC .99476 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Asp716Asn ENST00000454757.6:c.2146G>A 7:g.55174818G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AM-5821-01 1651151 1565938 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV99291226 COSM7552389 133231100 c.989C>T p.A330V Substitution - Missense 38 7:55156650-55156650 + - PATHOGENIC .98971 Confirmed somatic variant 376 NS NS 68 ENSP00000415559.1:p.Ala330Val ENST00000455089.5:c.989C>T 7:g.55156650C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001261 1001261 918484 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982789 982789 898508 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001821-T01-IM3 2718057 2576878 soft_tissue smooth_muscle endometrium NS leiomyosarcoma NS NS NS n COSV51806557 COSM6919399 133250140 c.2660G>A p.R887H Substitution - Missense het 38 7:55198810-55198810 + - PATHOGENIC .99081 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Arg887His ENST00000455089.5:c.2660G>A 7:g.55198810G>A EGFR ENST00000275493.6 3633 3236 920108 920108 837187 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51816100 COSM13430 99401741 c.2515G>A p.A839T Substitution - Missense hom 38 7:55191764-55191764 + - PATHOGENIC .98912 Confirmed somatic variant 15623594 surgery-fixed NS 59 ENSP00000275493.2:p.Ala839Thr ENST00000275493.6:c.2515G>A 7:g.55191764G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008450-T01-IM5 2724567 2583388 skin NS NS NS malignant_melanoma NS NS NS n COSV51822498 COSM3266565 133238887 c.782C>T p.S261L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ser261Leu ENST00000455089.5:c.782C>T 7:g.55155857C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A062-T-S27 2757400 2615999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152758 2152758 2021768 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460156 1460156 1384033 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458697 1458697 1382672 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006139-T01-IM5 2722519 2581340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152763 2152763 2021773 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471553 1471553 1395292 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811980 2811980 2668502 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006210-T01-IM5 2722589 2581410 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003116-T01-IM5 2719610 2578431 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876611 2876611 2731126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 148 898384 815996 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458688 1458688 1382663 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004837-T01-IM5 2721240 2580061 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51812540 COSM1451536 132566366 c.322A>G p.R108G Substitution - Missense het 38 7:55143386-55143386 + - PATHOGENIC .72671 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Arg108Gly ENST00000454757.6:c.322A>G 7:g.55143386A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AR-A2LR-01 2187807 2056085 breast NS NS NS carcinoma NS NS NS y COSV51781835 COSM174732 132552286 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 414 NS NS 49 ENSP00000395243.3:p.Glu114Lys ENST00000454757.6:c.340G>A 7:g.55143404G>A EGFR ENST00000275493.6 3633 3236 S06-38853-TP 2366573 2229456 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51792018 COSM4992972 99378183 c.3134C>T p.S1045F Substitution - Missense het 38 7:55201754-55201754 + - PATHOGENIC .97067 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000275493.2:p.Ser1045Phe ENST00000275493.6:c.3134C>T 7:g.55201754C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-2565-01 1337884 1248269 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-S9-A7IX-01 2263383 2130367 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 57 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_C30 1863711 1754602 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 22975805 surgery fresh/frozen primary 38 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-VS026-T1 2869846 2724843 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV51846033 COSM5530399 132568942 c.2621C>T p.P874L Substitution - Missense 38 7:55198771-55198771 + - PATHOGENIC .97363 Confirmed somatic variant 26950094 surgery fresh/frozen NS 58 ENSP00000395243.3:p.Pro874Leu ENST00000454757.6:c.2621C>T 7:g.55198771C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PTC-7C 2185970 2054267 thyroid NS NS NS other neoplasm NS NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 589 NS NS ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1881391 1881391 1771542 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM28574 178384302 c.? p.P848L Substitution - Missense + - Confirmed somatic variant 23362162 surgery-fixed NS ENSP00000275493.2:p.Pro848Leu EGFR_ENST00000454757 ENST00000454757.6 3498 3236 YUSCO 2013686 1896318 skin NS NS NS malignant_melanoma NS NS NS y COSV51778830 COSM1698691 132552104 c.1063G>A p.E355K Substitution - Missense het 38 7:55156823-55156823 + - PATHOGENIC .99571 Confirmed somatic variant 22842228 NS NS ENSP00000395243.3:p.Glu355Lys ENST00000454757.6:c.1063G>A 7:g.55156823G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003350-T01-IM5 2719841 2578662 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51815967 COSM39522 132550299 c.520T>G p.C174G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Cys174Gly ENST00000454757.6:c.520T>G 7:g.55152572T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S0361 897613 815236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15118125 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460151 1460151 1384028 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489244 1489244 1412402 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152771 2152771 2021781 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 961851 961851 878135 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16467080 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A017-T-S16 2757377 2615994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 56 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489242 1489242 1412400 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 65 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004982 1004982 922194 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009623-T01-IM5 2725517 2584338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1063624 1063624 979669 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004678-T01-IM5 2721078 2579899 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A028-T-S18 2757395 2615998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876667 2876667 2731182 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 71 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 IGC-04-1168 2662309 2522433 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812082 2812082 2668551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 133206440 c.2113G>C p.A705P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Confirmed somatic variant 31534501 pleural effusion NS 68 ENSP00000415559.1:p.Ala705Pro ENST00000455089.5:c.2113G>C 7:g.55174785G>C EGFR ENST00000275493.6 3633 3236 TCGA-BA-6872-01 2193616 2061894 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99294544 COSM8387616 99397476 c.571G>A p.D191N Substitution - Missense 38 7:55151305-55151305 + - PATHOGENIC .93234 Confirmed somatic variant 627 NS NS 47 ENSP00000275493.2:p.Asp191Asn ENST00000275493.6:c.571G>A 7:g.55151305G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2503528 2503528 2365878 autonomic_ganglia sinonasal_and_nasal_cavity NS NS olfactory_neuroblastoma NS NS NS n COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense het 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 27149458 surgery - NOS NS 44 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MTP18_T2 2875798 2730360 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 32796935 surgery-fixed NS 74 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AM-5820-01 1651150 1565937 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 376 NS NS 59 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1004996 1004996 922208 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982876 982876 898595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152785 2152785 2021795 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876059 2876059 2730574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 77 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471537 1471537 1395276 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1044283 1044283 960624 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489249 1489249 1412407 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006290-T01-IM5 2722667 2581488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51839751 COSM6949885 132564475 c.1791G>T p.K597N Substitution - Missense het 38 7:55172989-55172989 + - PATHOGENIC .95891 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Lys597Asn ENST00000454757.6:c.1791G>T 7:g.55172989G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EXTERN_MELA_20140514_002 2839308 2695074 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51866168 COSM3266611 132567358 c.1705G>A p.G569S Substitution - Missense 38 7:55165397-55165397 + - NEUTRAL .00559 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000395243.3:p.Gly569Ser ENST00000454757.6:c.1705G>A 7:g.55165397G>A EGFR ENST00000275493.6 3633 3236 TCGA-28-5207-01 2120332 1994568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 71 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S001073 1027682 944658 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008310-T01-IM5 2724436 2583257 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876033 2876033 2730548 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 44 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 J80_T 2194988 2063266 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51805367 COSM3950642 99407361 c.1039G>A p.D347N Substitution - Missense 38 7:55156565-55156565 + - PATHOGENIC .82248 Confirmed somatic variant 583 NS NS ENSP00000275493.2:p.Asp347Asn ENST00000275493.6:c.1039G>A 7:g.55156565G>A EGFR ENST00000275493.6 3633 3236 ILMN13 2816773 2673124 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51797307 COSM1090871 99399215 c.1310C>A p.S437Y Substitution - Missense 38 7:55160150-55160150 + - PATHOGENIC .98943 Confirmed somatic variant 29937994 surgery fresh/frozen NS 54 ENSP00000275493.2:p.Ser437Tyr ENST00000275493.6:c.1310C>A 7:g.55160150C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010634-T01-IM5 2726322 2585143 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51847135 COSM6975718 132598036 c.3074G>C p.S1025T Substitution - Missense het 38 7:55202563-55202563 + - PATHOGENIC .94366 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ser1025Thr ENST00000454757.6:c.3074G>C 7:g.55202563G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152784 2152784 2021794 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206717 1206717 1118595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002207-T01-IM3 2718499 2577320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003316-T01-IM5 2719809 2578630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000785-T01-IM3 2715984 2574805 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152787 2152787 2021797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002489-T01-IM3 2718761 2577582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005370-T01-IM5 2721774 2580595 skin NS NS NS malignant_melanoma NS NS NS n COSV51794869 COSM4362780 133204758 c.439C>T p.P147S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Pro147Ser ENST00000455089.5:c.439C>T 7:g.55151308C>T EGFR ENST00000275493.6 3633 3236 TCGA-D7-6521-01 2198059 2066337 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51778897 COSM3881800 99437868 c.253G>A p.V85M Substitution - Missense 38 7:55143317-55143317 + - PATHOGENIC .99051 Confirmed somatic variant 541 NS NS 65 ENSP00000275493.2:p.Val85Met ENST00000275493.6:c.253G>A 7:g.55143317G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982775 982775 898494 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001245 1001245 918468 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 2876033 2876033 2730548 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 44 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0008310-T01-IM5 2724436 2583257 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-28-1757-01 2178083 2046381 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 71 ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 1468618 1468618 1392369 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM53177 178381723 c.? p.G779C Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Gly779Cys EGFR ENST00000275493.6 3633 3236 SJHYPO052-R 2590153 2451283 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 99381154 c.1279C>T p.R427C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 23334668 blood-bone marrow recurrent 16.3 ENSP00000275493.2:p.Arg427Cys ENST00000275493.6:c.1279C>T 7:g.55157734C>T EGFR ENST00000275493.6 3633 3236 HCC827 2776313 2634449 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS y COSV51789379 COSM4362784 99395153 c.2237A>C p.E746A Substitution - Missense 38 7:55174774-55174774 + - PATHOGENIC .97548 Confirmed somatic variant 29681454 NS NS 38 ENSP00000275493.2:p.Glu746Ala ENST00000275493.6:c.2237A>C 7:g.55174774A>C EGFR ENST00000275493.6 3633 3236 P-0003693-T01-IM5 2720182 2579003 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51805704 COSM6930161 99378196 c.3372C>G p.H1124Q Substitution - Missense het 38 7:55205356-55205356 + - NEUTRAL .41128 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.His1124Gln ENST00000275493.6:c.3372C>G 7:g.55205356C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1040369 1040369 956946 central_nervous_system brain NS NS glioma oligoastrocytoma_Grade_III anaplastic NS n COSV51790148 COSM22555 133209794 c.1895G>A p.R632H Substitution - Missense 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000415559.1:p.Arg632His ENST00000455089.5:c.1895G>A 7:g.55173093G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1040370 1040370 956947 central_nervous_system brain NS NS glioma oligoastrocytoma_Grade_III anaplastic NS n COSV51790148 COSM22555 133209794 c.1895G>A p.R632H Substitution - Missense 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000415559.1:p.Arg632His ENST00000455089.5:c.1895G>A 7:g.55173093G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577025 COSM9413133 132621863 c.1191C>G p.S397R Substitution - Missense 38 7:55160166-55160166 + - NEUTRAL .15107 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000395243.3:p.Ser397Arg ENST00000454757.6:c.1191C>G 7:g.55160166C>G EGFR ENST00000275493.6 3633 3236 P-0007018-T01-IM5 2723393 2582214 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765787 COSM2149971 99378201 c.910C>T p.H304Y Substitution - Missense het 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.His304Tyr ENST00000275493.6:c.910C>T 7:g.55155850C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 896925 896925 814548 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51771864 COSM6226 132555722 c.2191C>T p.R731C Substitution - Missense 38 7:55181335-55181335 + - PATHOGENIC .97187 Confirmed somatic variant 15329413 surgery-fixed NS ENSP00000395243.3:p.Arg731Cys ENST00000454757.6:c.2191C>T 7:g.55181335C>T EGFR ENST00000275493.6 3633 3236 P-0005845-T02-IM5 2722231 2581052 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 25 897186 814809 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471555 1471555 1395294 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876066 2876066 2730581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920028 920028 837107 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 53 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489251 1489251 1412409 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0003096-T01-IM5 2719590 2578411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005114-T01-IM5 2721517 2580338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780877 COSM26717 132548732 c.2444A>T p.K815I Substitution - Missense het 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Lys815Ile ENST00000454757.6:c.2444A>T 7:g.55191828A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1109718 1109718 1023628 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51780877 COSM26717 132548732 c.2444A>T p.K815I Substitution - Missense het 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 18372921 surgery-fixed primary 88 ENSP00000395243.3:p.Lys815Ile ENST00000454757.6:c.2444A>T 7:g.55191828A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 M692PT 2671812 2531371 pleura NS NS NS mesothelioma epithelial NS NS n COSV51783428 COSM6848064 132562284 c.2795G>A p.R932H Substitution - Missense 38 7:55200397-55200397 + - PATHOGENIC .99379 Confirmed somatic variant 26928227 surgery fresh/frozen primary 69 ENSP00000395243.3:p.Arg932His ENST00000454757.6:c.2795G>A 7:g.55200397G>A EGFR ENST00000275493.6 3633 3236 PTC-7C 2185970 2054267 thyroid NS NS NS other neoplasm NS NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 589 NS NS ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-28-5207-01 2120332 1994568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 71 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009655-T01-IM5 2725548 2584369 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876066 2876066 2730581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 75 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0005127-T01-IM5 2721532 2580353 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51794869 COSM4362780 99376586 c.574C>T p.P192S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Pro192Ser ENST00000275493.6:c.574C>T 7:g.55151308C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1505362 1505362 1428240 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51797142 COSM87246 132608647 c.2426C>T p.T809I Substitution - Missense 38 7:55191810-55191810 + - PATHOGENIC .97885 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000395243.3:p.Thr809Ile ENST00000454757.6:c.2426C>T 7:g.55191810C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920108 920108 837187 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51816100 COSM13430 133227287 c.2380G>A p.A794T Substitution - Missense hom 38 7:55191764-55191764 + - PATHOGENIC .98912 Confirmed somatic variant 15623594 surgery-fixed NS 59 ENSP00000415559.1:p.Ala794Thr ENST00000455089.5:c.2380G>A 7:g.55191764G>A EGFR ENST00000275493.6 3633 3236 2876066 2876066 2730581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 75 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0009655-T01-IM5 2725548 2584369 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 19T 2745856 2604559 liver NS NS NS other neoplasm NS NS y COSV51840438 COSM1727959 132565624 c.374A>G p.Y125C Substitution - Missense 38 7:55143438-55143438 + - PATHOGENIC .99088 Confirmed somatic variant 660 NS primary 71 ENSP00000395243.3:p.Tyr125Cys ENST00000454757.6:c.374A>G 7:g.55143438A>G EGFR ENST00000275493.6 3633 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV104369003 COSM9233187 99412118 c.2296A>T p.M766L Substitution - Missense het 38 7:55181305-55181305 + - PATHOGENIC .98406 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000275493.2:p.Met766Leu ENST00000275493.6:c.2296A>T 7:g.55181305A>T EGFR ENST00000275493.6 3633 3236 P-0008927-T01-IM5 2724943 2583764 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51768139 COSM21685 99377226 c.866C>A p.A289D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Asp ENST00000275493.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV104369002 COSM9233243 133238550 c.2095A>T p.I699F Substitution - Missense het 38 7:55174767-55174767 + - PATHOGENIC .99604 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000415559.1:p.Ile699Phe ENST00000455089.5:c.2095A>T 7:g.55174767A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010345-T02-IM5 2726112 2584933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790040 COSM6978158 132564742 c.2364_2365delinsTT p.L788_V789delinsFL Substitution - Missense het 38 7:55191748-55191749 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu788_Val789delinsPheLeu ENST00000454757.6:c.2364_2365delinsTT 7:g.55191748_55191749delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Pat_01_B 2492838 2355452 NS NS NS NS malignant_melanoma NS NS NS y COSV51817615 COSM5872885 133232635 c.2654G>A p.G885E Substitution - Missense 38 7:55198804-55198804 + - PATHOGENIC .99081 Confirmed somatic variant 24265153 surgery-fixed NS 45 ENSP00000415559.1:p.Gly885Glu ENST00000455089.5:c.2654G>A 7:g.55198804G>A EGFR ENST00000275493.6 3633 3236 P-0008476-T01-IM5 2724590 2583411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003871-T01-IM5 2720365 2579186 skin NS NS NS malignant_melanoma NS NS NS n COSV51836372 COSM6931354 133258543 c.2875G>A p.E959K Substitution - Missense het 38 7:55201251-55201251 + - PATHOGENIC .98827 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Glu959Lys ENST00000455089.5:c.2875G>A 7:g.55201251G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1589269 1589269 1510423 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51843707 COSM28601 133206370 c.2000T>C p.F667S Substitution - Missense 38 7:55173994-55173994 + - PATHOGENIC .9621 Confirmed somatic variant 22026926 surgery fresh/frozen NS ENSP00000415559.1:p.Phe667Ser ENST00000455089.5:c.2000T>C 7:g.55173994T>C EGFR ENST00000275493.6 3633 3236 920111 920111 837190 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 15623594 surgery-fixed NS 66 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2876623 2876623 2731138 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 29506987 circulating tumour NS 86 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 019T 2067099 1946896 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51840438 COSM1727959 133222062 c.374A>G p.Y125C Substitution - Missense 38 7:55143438-55143438 + - PATHOGENIC .99088 Confirmed somatic variant 23788652 surgery - NOS primary ENSP00000415559.1:p.Tyr125Cys ENST00000455089.5:c.374A>G 7:g.55143438A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2014_Lung_sq_06_T 2744877 2603580 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 77 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 RS33T 2653643 2513765 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS primary 67.09 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001246 1001246 918469 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 S06-38853-TP 2366573 2229456 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51796296 COSM4992967 99432637 c.1640G>A p.R547K Substitution - Missense het 38 7:55163741-55163741 + - PATHOGENIC .992 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000275493.2:p.Arg547Lys ENST00000275493.6:c.1640G>A 7:g.55163741G>A EGFR ENST00000275493.6 3633 3236 P-0003739-T01-IM5 2720227 2579048 soft_tissue blood_vessel skin NS angiosarcoma NS NS NS n COSV51783517 COSM3639743 99373241 c.1864C>T p.P622S Substitution - Missense het 38 7:55165421-55165421 + - NEUTRAL .20892 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Pro622Ser ENST00000275493.6:c.1864C>T 7:g.55165421C>T EGFR ENST00000275493.6 3633 3236 P-0001442-T02-IM5 2719422 2578243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1001259 1001259 918482 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0004714-T01-IM5 2721118 2579939 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471542 1471542 1395281 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A014-T-S55 2758141 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0649-01 1337849 1248234 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51791901 COSM2151461 133242102 c.856G>A p.G286R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .96902 Confirmed somatic variant 329 surgery fresh/frozen NS 73 ENSP00000415559.1:p.Gly286Arg ENST00000455089.5:c.856G>A 7:g.55155931G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2857072 2857072 2712372 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV105110417 COSM9522635 133241595 c.2371C>G p.R791G Substitution - Missense 38 7:55191755-55191755 + - PATHOGENIC .96487 Confirmed somatic variant 31937902 surgery-fixed NS 17 ENSP00000415559.1:p.Arg791Gly ENST00000455089.5:c.2371C>G 7:g.55191755C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005701-T01-IM5 2722086 2580907 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EE-A20C-06 2121628 1995864 skin NS NS NS malignant_melanoma NS NS NS y COSV51765811 COSM3639748 132552757 c.2074A>G p.K692E Substitution - Missense 38 7:55174746-55174746 + - PATHOGENIC .92243 Confirmed somatic variant 540 NS NS 59 ENSP00000395243.3:p.Lys692Glu ENST00000454757.6:c.2074A>G 7:g.55174746A>G EGFR ENST00000275493.6 3633 3236 1165892 1165892 1078206 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51785733 COSM28575 99408096 c.2650G>A p.E884K Substitution - Missense het 38 7:55192790-55192790 + - PATHOGENIC .9655 Confirmed somatic variant 16407879 surgery - NOS metastasis 70 ENSP00000275493.2:p.Glu884Lys ENST00000275493.6:c.2650G>A 7:g.55192790G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577024 COSM9413134 132621856 c.1187T>A p.V396D Substitution - Missense 38 7:55160162-55160162 + - PATHOGENIC .92743 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000395243.3:p.Val396Asp ENST00000454757.6:c.1187T>A 7:g.55160162T>A EGFR ENST00000275493.6 3633 3236 2901990 2901990 2756229 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Leu861Arg EGFR ENST00000275493.6 3633 3236 TCGA-EE-A2MI-06 2121680 1995916 skin NS NS NS malignant_melanoma NS NS NS y COSV51783517 COSM3639743 99373241 c.1864C>T p.P622S Substitution - Missense 38 7:55165421-55165421 + - NEUTRAL .20892 Confirmed somatic variant 540 NS NS 43 ENSP00000275493.2:p.Pro622Ser ENST00000275493.6:c.1864C>T 7:g.55165421C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-MT-A67A-01 2193588 2061866 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51853450 COSM53290 132553338 c.2480A>G p.E827G Substitution - Missense 38 7:55191864-55191864 + - PATHOGENIC .986 Confirmed somatic variant 627 NS NS 85 ENSP00000395243.3:p.Glu827Gly ENST00000454757.6:c.2480A>G 7:g.55191864A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460101 1460101 1383978 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51799041 COSM52931 132576030 c.2060T>C p.I687T Substitution - Missense 38 7:55174732-55174732 + - PATHOGENIC .98814 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000395243.3:p.Ile687Thr ENST00000454757.6:c.2060T>C 7:g.55174732T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-0670-01 2178104 2046402 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 132551880 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 NS NS 60 ENSP00000395243.3:p.Thr218Pro ENST00000454757.6:c.652A>C 7:g.55154050A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004837-T01-IM5 2721240 2580061 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 ATL020 2488648 2351297 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm adult_T_cell_lymphoma-leukaemia NS NS y COSV51770269 COSM5710629 132578546 c.880G>A p.G294R Substitution - Missense 38 7:55156541-55156541 + - PATHOGENIC .9949 Confirmed somatic variant 26437031 NS NS 63 ENSP00000395243.3:p.Gly294Arg ENST00000454757.6:c.880G>A 7:g.55156541G>A EGFR ENST00000275493.6 3633 3236 S001073 1027682 944658 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 P-0001442-T02-IM5 2719422 2578243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1040384 1040384 956961 central_nervous_system brain NS NS glioma oligoastrocytoma NS NS n COSV51790148 COSM22555 133209794 c.1895G>A p.R632H Substitution - Missense 38 7:55173093-55173093 + - PATHOGENIC .99822 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000415559.1:p.Arg632His ENST00000455089.5:c.1895G>A 7:g.55173093G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 ILMN13 2816773 2673124 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51797307 COSM1090871 133224328 c.1175C>A p.S392Y Substitution - Missense 38 7:55160150-55160150 + - PATHOGENIC .98943 Confirmed somatic variant 29937994 surgery fresh/frozen NS 54 ENSP00000415559.1:p.Ser392Tyr ENST00000455089.5:c.1175C>A 7:g.55160150C>A EGFR ENST00000275493.6 3633 3236 P-0004706-T01-IM5 2721110 2579931 eye uveal_tract NS NS malignant_melanoma NS NS NS n COSV51862598 COSM6938266 99374093 c.2024G>A p.R675Q Substitution - Missense het 38 7:55173087-55173087 + - PATHOGENIC .98305 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Arg675Gln ENST00000275493.6:c.2024G>A 7:g.55173087G>A EGFR ENST00000275493.6 3633 3236 920035 920035 837114 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 52 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 914588 914588 832037 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1165892 1165892 1078206 lung right_middle_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16407879 surgery - NOS metastasis 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152786 2152786 2021796 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 961854 961854 878138 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16467080 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489239 1489239 1412397 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 41 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 914591 914591 832040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152796 2152796 2021806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 94271 2807578 2664279 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 24807215 surgery fresh/frozen primary 60 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811925 2811925 2668484 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51823614 COSM4170219 132547383 c.2120C>T p.S707F Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98332 Confirmed somatic variant 31534501 pleural effusion NS 61 ENSP00000395243.3:p.Ser707Phe ENST00000454757.6:c.2120C>T 7:g.55174792C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001442-T02-IM5 2719422 2578243 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011544-T01-IM5 2727116 2585937 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51774354 COSM6981709 133276040 c.816G>C p.E272D Substitution - Missense het 38 7:55155891-55155891 + - PATHOGENIC .93673 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Glu272Asp ENST00000455089.5:c.816G>C 7:g.55155891G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1472949 1472949 1396648 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51773206 COSM28603 133217070 c.2158G>A p.V720M Substitution - Missense 38 7:55181302-55181302 + - PATHOGENIC .97963 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000415559.1:p.Val720Met ENST00000455089.5:c.2158G>A 7:g.55181302G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005370-T01-IM5 2721774 2580595 skin NS NS NS malignant_melanoma NS NS NS n COSV51794869 COSM4362780 132549800 c.439C>T p.P147S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Pro147Ser ENST00000454757.6:c.439C>T 7:g.55151308C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005255 1005255 922467 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51773392 COSM20892 132592219 c.2276A>G p.E759G Substitution - Missense 38 7:55181420-55181420 + - PATHOGENIC .9793 Confirmed somatic variant 16720329 surgery-fixed primary 62 ENSP00000395243.3:p.Glu759Gly ENST00000454757.6:c.2276A>G 7:g.55181420A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0012056-T01-IM5 2727199 2586020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51827170 COSM6982292 132611872 c.3418G>A p.G1140S Substitution - Missense het 38 7:55205537-55205537 + - PATHOGENIC .9751 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly1140Ser ENST00000454757.6:c.3418G>A 7:g.55205537G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876595 2876595 2731110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010345-T02-IM5 2726112 2584933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 65 897198 814821 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982878 982878 898597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005016 1005016 922228 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A021-T-S14 2757380 2615995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 57 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812108 2812108 2668564 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 59 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458703 1458703 1382678 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004691-T02-IM5 2721093 2579914 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-2563 2108004 1985865 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 132553689 c.619C>T p.R207C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Arg207Cys ENST00000454757.6:c.619C>T 7:g.55154017C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876611 2876611 2731126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 133219834 c.2239C>T p.L747F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000415559.1:p.Leu747Phe ENST00000455089.5:c.2239C>T 7:g.55181383C>T EGFR ENST00000275493.6 3633 3236 2876595 2876595 2731110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001914-T01-IM3 2718230 2577051 central_nervous_system brain NS NS glioma astrocytoma NS NS n COSV51779794 COSM53264 133215961 c.2039C>T p.T680M Substitution - Missense het 38 7:55174033-55174033 + - PATHOGENIC .97744 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr680Met ENST00000455089.5:c.2039C>T 7:g.55174033C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1468095 1468095 1391941 peritoneum NS NS NS mesothelioma NS NS NS n COSV51818388 COSM53104 132574245 c.2255G>A p.C752Y Substitution - Missense het 38 7:55181399-55181399 + - PATHOGENIC .98244 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000395243.3:p.Cys752Tyr ENST00000454757.6:c.2255G>A 7:g.55181399G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006541-T01-IM5 2722916 2581737 NS NS NS NS malignant_melanoma NS NS NS n COSV51823220 COSM13179 132558313 c.1945C>T p.P649S Substitution - Missense het 38 7:55173939-55173939 + - PATHOGENIC .97389 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Pro649Ser ENST00000454757.6:c.1945C>T 7:g.55173939C>T EGFR ENST00000275493.6 3633 3236 2901982 2901982 2756227 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Leu861Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001328-T01-IM3 2717084 2575905 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SJOS011_D 2372211 2235004 bone tibia NS NS osteosarcoma osteoblastic NS NS y COSV51845937 COSM5024343 133277314 c.2770T>C p.S924P Substitution - Missense 38 7:55200372-55200372 + - PATHOGENIC .91352 Confirmed somatic variant 24703847 NS primary 13 ENSP00000415559.1:p.Ser924Pro ENST00000455089.5:c.2770T>C 7:g.55200372T>C EGFR ENST00000275493.6 3633 3236 16724 1423709 1333737 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1103792 1103792 1018044 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0005264-T01-IM5 2721663 2580484 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 NS metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1043303 1043303 959644 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17186532 surgery-fixed NS 57 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982862 982862 898581 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1004983 1004983 922195 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A102-T-S29 2757413 2616002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152772 2152772 2021782 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A028-T-S21 2757396 2615998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0003573-T02-IM5 2720059 2578880 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0002783-T01-IM3 2719014 2577835 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0008664-T01-IM5 2724728 2583549 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SJHYPO052-R 2590153 2451283 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 133209467 c.1144C>T p.R382C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 23334668 blood-bone marrow recurrent 16.3 ENSP00000415559.1:p.Arg382Cys ENST00000455089.5:c.1144C>T 7:g.55157734C>T EGFR ENST00000275493.6 3633 3236 TCGA-A4-7583-01 2194049 2062327 kidney NS NS NS carcinoma papillary_renal_cell_carcinoma NS NS y COSV99289232 COSM8238800 99399642 c.3466C>A p.H1156N Substitution - Missense 38 7:55205450-55205450 + - NEUTRAL .21235 Confirmed somatic variant 543 NS NS 60 ENSP00000275493.2:p.His1156Asn ENST00000275493.6:c.3466C>A 7:g.55205450C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-0707-01 2178095 2046393 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 133207083 c.674A>G p.Y225C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 329 NS NS 55 ENSP00000415559.1:p.Tyr225Cys ENST00000455089.5:c.674A>G 7:g.55154072A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 YUKLAB 2013569 1896201 skin NS NS NS malignant_melanoma NS NS NS y COSV51796177 COSM1698689 133245563 c.1054A>T p.T352S Substitution - Missense het 38 7:55156814-55156814 + - PATHOGENIC .9893 Confirmed somatic variant 22842228 surgery fresh/frozen metastasis 84 ENSP00000415559.1:p.Thr352Ser ENST00000455089.5:c.1054A>T 7:g.55156814A>T EGFR ENST00000275493.6 3633 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV104369001 COSM9233242 99412102 c.2146A>G p.K716E Substitution - Missense het 38 7:55174005-55174005 + - PATHOGENIC .95934 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000275493.2:p.Lys716Glu ENST00000275493.6:c.2146A>G 7:g.55174005A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BR-4256-01 2198141 2066419 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51797215 COSM145360 132558158 c.832G>A p.V278I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 541 NS NS 80 ENSP00000395243.3:p.Val278Ile ENST00000454757.6:c.832G>A 7:g.55155907G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SC-her2-025 2313847 2179043 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51850822 COSM4771564 132562913 c.2461G>C p.E821Q Substitution - Missense 38 7:55191845-55191845 + - PATHOGENIC .99128 Confirmed somatic variant 24185512 surgery fresh/frozen metastasis ENSP00000395243.3:p.Glu821Gln ENST00000454757.6:c.2461G>C 7:g.55191845G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-2567-01 1337886 1248271 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51816377 COSM3412194 133203358 c.1651C>T p.P551S Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99531 Confirmed somatic variant 329 surgery fresh/frozen NS 65 ENSP00000415559.1:p.Pro551Ser ENST00000455089.5:c.1651C>T 7:g.55165343C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577027 COSM9413135 132564218 c.1259G>A p.G420E Substitution - Missense 38 7:55160234-55160234 + - NEUTRAL .11765 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000395243.3:p.Gly420Glu ENST00000454757.6:c.1259G>A 7:g.55160234G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0125-02 2120245 1994481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 64 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-26-1439-01 2120320 1994556 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 63 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 P-0008577-T02-IM5 2724678 2583499 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206735 1206735 1118613 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-L9-A50W-01 2263346 2130330 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS primary 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471539 1471539 1395278 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0002783-T01-IM3 2719014 2577835 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006622-T01-IM5 2829996 2685811 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51845994 COSM5530405 133202750 c.1498G>A p.E500K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 30205045 surgery-fixed primary 43 ENSP00000415559.1:p.Glu500Lys ENST00000455089.5:c.1498G>A 7:g.55163734G>A EGFR ENST00000275493.6 3633 3236 1322273 1322273 1233160 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 43 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LC_C24 1863705 1754596 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982872 982872 898591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0006561-T02-IM5 2722939 2581760 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1322267 1322267 1233154 lung NS NS NS other hyperplasia NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 84 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876611 2876611 2731126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 99392449 c.2374C>T p.L792F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000275493.2:p.Leu792Phe ENST00000275493.6:c.2374C>T 7:g.55181383C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002783-T01-IM3 2719014 2577835 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152758 2152758 2021768 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51836903 COSM3734670 133207578 c.2294G>C p.G765A Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98511 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Gly765Ala ENST00000455089.5:c.2294G>C 7:g.55181438G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152698 2152698 2021708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 PCA1587 2861424 2716668 prostate NS NS NS carcinoma NS NS NS n COSV105111146 COSM9581090 99449139 c.1879G>C p.G627R Substitution - Missense 38 7:55165436-55165436 + - PATHOGENIC .99177 Confirmed somatic variant 32268276 circulating tumour NS ENSP00000275493.2:p.Gly627Arg ENST00000275493.6:c.1879G>C 7:g.55165436G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BA-6872-01 2193616 2061894 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99294544 COSM8387616 133223205 c.436G>A p.D146N Substitution - Missense 38 7:55151305-55151305 + - PATHOGENIC .93234 Confirmed somatic variant 627 NS NS 47 ENSP00000415559.1:p.Asp146Asn ENST00000455089.5:c.436G>A 7:g.55151305G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-2563-01 1337882 1248267 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 99380629 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000275493.2:p.Arg252Cys ENST00000275493.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1109720 1109720 1023630 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 18372921 surgery-fixed primary 72 ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 18195 2422953 2285875 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV51779680 COSM1313184 132574162 c.1016C>G p.T339S Substitution - Missense 38 7:55156776-55156776 + - PATHOGENIC .98418 Confirmed somatic variant 24469795 NS NS 61 ENSP00000395243.3:p.Thr339Ser ENST00000454757.6:c.1016C>G 7:g.55156776C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006441-T01-IM5 2722817 2581638 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51775191 COSM1451530 133205080 c.187G>A p.G63R Substitution - Missense het 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly63Arg ENST00000455089.5:c.187G>A 7:g.55142384G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-3650-01 2120284 1994520 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 46 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-L9-A50W-01 2263346 2130330 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 417 NS primary 75 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 245 898397 816009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1790527 1790527 1693506 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51815927 COSM24971 132563635 c.2378T>C p.L793P Substitution - Missense 38 7:55191762-55191762 + - PATHOGENIC .97813 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000395243.3:p.Leu793Pro ENST00000454757.6:c.2378T>C 7:g.55191762T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-28-5209-01 2120334 1994570 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51808387 COSM3412196 132564457 c.1658G>C p.G553A Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 329 NS NS 66 ENSP00000395243.3:p.Gly553Ala ENST00000454757.6:c.1658G>C 7:g.55165350G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-EE-A20C-06 2121628 1995864 skin NS NS NS malignant_melanoma NS NS NS y COSV51765811 COSM3639748 133207801 c.2074A>G p.K692E Substitution - Missense 38 7:55174746-55174746 + - PATHOGENIC .92243 Confirmed somatic variant 540 NS NS 59 ENSP00000415559.1:p.Lys692Glu ENST00000455089.5:c.2074A>G 7:g.55174746A>G EGFR ENST00000275493.6 3633 3236 TCGA-L9-A50W-01 2263346 2130330 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 417 NS primary 75 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002614-T01-IM3 2718868 2577689 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense het 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006714-T01-IM5 2723094 2581915 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51834490 COSM6953161 133255080 c.2494C>G p.P832A Substitution - Missense het 38 7:55192769-55192769 + - PATHOGENIC .95807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Pro832Ala ENST00000455089.5:c.2494C>G 7:g.55192769C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A065-T-S22 2757404 2616000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002403-T01-IM3 2718680 2577501 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0012076-T01-IM5 2727219 2586040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489247 1489247 1412405 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982869 982869 898588 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876602 2876602 2731117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 57 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1322264 1322264 1233151 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 52 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002999-T01-IM3 2719208 2578029 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 133211383 c.620G>A p.R207H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg207His ENST00000455089.5:c.620G>A 7:g.55154018G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-2563-01 1337882 1248267 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 133208833 c.619C>T p.R207C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000415559.1:p.Arg207Cys ENST00000455089.5:c.619C>T 7:g.55154017C>T EGFR ENST00000275493.6 3633 3236 S0377 897601 815224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 15118125 surgery - NOS primary ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 P-0000154-T01-IM3 2714713 2573534 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51819471 COSM6909030 99399807 c.1273A>C p.I425L Substitution - Missense het 38 7:55157728-55157728 + - PATHOGENIC .99224 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ile425Leu ENST00000275493.6:c.1273A>C 7:g.55157728A>C EGFR ENST00000275493.6 3633 3236 P-0005378-T01-IM5 2721782 2580603 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51862161 COSM6943352 99373581 c.73C>G p.L25V Substitution - Missense het 38 7:55019350-55019350 + - NEUTRAL .21138 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Leu25Val ENST00000275493.6:c.73C>G 7:g.55019350C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51767677 COSM25016 133209614 c.2200G>A p.G734S Substitution - Missense het 38 7:55181344-55181344 + - PATHOGENIC .98244 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000415559.1:p.Gly734Ser ENST00000455089.5:c.2200G>A 7:g.55181344G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 TCGA-26-1439-01 2120320 1994556 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 63 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 TCGA-06-0125-02 2120245 1994481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 64 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51770694 COSM20891 133218993 c.2251G>A p.G751S Substitution - Missense het 38 7:55181395-55181395 + - PATHOGENIC .98244 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000415559.1:p.Gly751Ser ENST00000455089.5:c.2251G>A 7:g.55181395G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-14-1455 2108036 1985897 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 133216524 c.953C>T p.T318I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Thr318Ile ENST00000455089.5:c.953C>T 7:g.55156614C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-14-0786-01 1337986 1248371 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1438353 1438353 1346127 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 132551897 c.2447T>G p.L816R Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 20823418 surgery fresh/frozen primary 76 ENSP00000395243.3:p.Leu816Arg ENST00000454757.6:c.2447T>G 7:g.55191831T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1790518 1790518 1693497 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51844033 COSM707173 132568428 c.2138A>G p.E713G Substitution - Missense 38 7:55174810-55174810 + - PATHOGENIC .9946 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000395243.3:p.Glu713Gly ENST00000454757.6:c.2138A>G 7:g.55174810A>G EGFR ENST00000275493.6 3633 3236 2862937 2862937 2718099 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM6843698 178388877 c.? p.A289D Substitution - Missense + - Confirmed somatic variant 26486077 surgery fresh/frozen NS 64 ENSP00000275493.2:p.Ala289Asp EGFR ENST00000275493.6 3633 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577025 COSM9413133 99460430 c.1326C>G p.S442R Substitution - Missense 38 7:55160166-55160166 + - NEUTRAL .15107 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000275493.2:p.Ser442Arg ENST00000275493.6:c.1326C>G 7:g.55160166C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002780-T01-IM3 2719011 2577832 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002768-T01-IM3 2719000 2577821 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 003 2640407 2500709 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 27545006 NS NS 66 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1468092 1468092 1391938 peritoneum NS NS NS mesothelioma NS NS NS n COSV51816047 COSM53101 132559524 c.2057G>T p.W686L Substitution - Missense het 38 7:55174729-55174729 + - PATHOGENIC .99891 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000395243.3:p.Trp686Leu ENST00000454757.6:c.2057G>T 7:g.55174729G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 133218349 c.1256C>T p.S419L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000415559.1:p.Ser419Leu ENST00000455089.5:c.1256C>T 7:g.55160231C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1894611 1894611 1783303 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51837871 COSM1238072 132620153 c.1501C>T p.P501S Substitution - Missense hom 38 7:55163737-55163737 + - PATHOGENIC .99252 Confirmed somatic variant 23578570 surgery-fixed NS 33 ENSP00000395243.3:p.Pro501Ser ENST00000454757.6:c.1501C>T 7:g.55163737C>T EGFR ENST00000275493.6 3633 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV104369000 COSM9233361 99412087 c.352G>T p.A118S Substitution - Missense het 38 7:55143416-55143416 + - PATHOGENIC .99878 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000275493.2:p.Ala118Ser ENST00000275493.6:c.352G>T 7:g.55143416G>T EGFR ENST00000275493.6 3633 3236 P-0004837-T01-IM5 2721240 2580061 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 P-0003116-T01-IM5 2719610 2578431 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51809537 COSM6926377 99391213 c.3041A>T p.D1014V Substitution - Missense het 38 7:55201282-55201282 + - PATHOGENIC .99519 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Asp1014Val ENST00000275493.6:c.3041A>T 7:g.55201282A>T EGFR ENST00000275493.6 3633 3236 PD42101a 2894816 2749304 skin trunk NS NS malignant_melanoma superficial_spreading NS NS y COSV51793030 COSM133566 99411956 c.2507G>A p.R836H Substitution - Missense 38 7:55191756-55191756 + - PATHOGENIC .98912 Confirmed somatic variant 33024263 surgery-fixed metastasis ENSP00000275493.2:p.Arg836His ENST00000275493.6:c.2507G>A 7:g.55191756G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152760 2152760 2021770 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 132551401 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Arg731His ENST00000454757.6:c.2192G>A 7:g.55181336G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CHG-12-12649T 2634294 2494690 liver NS NS NS other neoplasm NS NS y COSV51767687 COSM6191352 132547106 c.1612G>A p.A538T Substitution - Missense 38 7:55165304-55165304 + - PATHOGENIC .98656 Confirmed somatic variant 660 NS primary 50 ENSP00000395243.3:p.Ala538Thr ENST00000454757.6:c.1612G>A 7:g.55165304G>A EGFR ENST00000275493.6 3633 3236 SC-her2-025 2313847 2179043 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51850822 COSM4771564 99391623 c.2596G>C p.E866Q Substitution - Missense 38 7:55191845-55191845 + - PATHOGENIC .99128 Confirmed somatic variant 24185512 surgery fresh/frozen metastasis ENSP00000275493.2:p.Glu866Gln ENST00000275493.6:c.2596G>C 7:g.55191845G>C EGFR ENST00000275493.6 3633 3236 2876654 2876654 2731169 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 circulating tumour NS 63 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460147 1460147 1384024 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982775 982775 898494 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2906646 2906646 2760897 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29616327 surgery-fixed metastasis 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 702 898393 816005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001246 1001246 918469 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005845-T01-IM5 2722230 2581051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004998 1004998 922210 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005001 1005001 922213 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005010 1005010 922222 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004607-T03-IM5 2721003 2579824 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489259 1489259 1412417 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001245 1001245 918468 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002329-T01-IM3 2718615 2577436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 166 897193 814816 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982857 982857 898576 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-86-8668-01 2194764 2063042 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 61 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1790521 1790521 1693500 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 402 898388 816000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T521 2296252 2161855 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51822020 COSM4745530 132596116 c.2166_2167delinsGG p.S723G Substitution - Missense 38 7:55181310-55181311 + - Confirmed somatic variant 25344691 NS NS 62.83 ENSP00000395243.3:p.Ser723Gly ENST00000454757.6:c.2166_2167delinsGG 7:g.55181310_55181311delinsGG EGFR ENST00000275493.6 3633 3236 2150413 2150413 2019482 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 65 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2150420 2150420 2019489 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1471541 1471541 1395280 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982875 982875 898594 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458699 1458699 1382674 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920017 920017 837096 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004688-T01-IM5 2721089 2579910 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51823965 COSM6937748 133229941 c.76G>A p.E26K Substitution - Missense het 38 7:55019353-55019353 + - PATHOGENIC .70393 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Glu26Lys ENST00000455089.5:c.76G>A 7:g.55019353G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811952 2811952 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 133206840 c.2447T>G p.L816R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 31534501 pleural effusion NS 69 ENSP00000415559.1:p.Leu816Arg ENST00000455089.5:c.2447T>G 7:g.55191831T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011107-T01-IM5 2726736 2585557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 EXTERN_MELA_20140526_084 2839361 2695127 skin trunk NS NS malignant_melanoma NS NS NS y COSV104577151 COSM9446111 99395227 c.2222_2223delinsGT p.P741R Substitution - Missense 38 7:55174759-55174760 + - Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000275493.2:p.Pro741Arg ENST00000275493.6:c.2222_2223delinsGT 7:g.55174759_55174760delinsGT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152698 2152698 2021708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009459-T01-IM5 2725386 2584207 testis NS NS NS germ_cell_tumour mixed NS NS n COSV51822613 COSM6968786 133216470 c.92G>T p.C31F Substitution - Missense het 38 7:55142289-55142289 + - PATHOGENIC .99814 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Cys31Phe ENST00000455089.5:c.92G>T 7:g.55142289G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1487000 1487000 1410618 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51807094 COSM20893 132564889 c.2387G>A p.R796K Substitution - Missense 38 7:55191771-55191771 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 58 ENSP00000395243.3:p.Arg796Lys ENST00000454757.6:c.2387G>A 7:g.55191771G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 pfg043T 2309624 2174826 stomach NS NS NS carcinoma intestinal_adenocarcinoma NS NS y COSV51790826 COSM4755611 132552161 c.431A>C p.K144T Substitution - Missense het 38 7:55151300-55151300 + - PATHOGENIC .93585 Confirmed somatic variant 24816253 surgery fresh/frozen NS 76 ENSP00000395243.3:p.Lys144Thr ENST00000454757.6:c.431A>C 7:g.55151300A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002329-T01-IM3 2718615 2577436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 HCC-JP-457-T 2746985 2605688 liver NS NS NS other neoplasm NS NS y COSV51770509 COSM7191105 132578623 c.1735T>G p.C579G Substitution - Missense 38 7:55165427-55165427 + - PATHOGENIC .99836 Confirmed somatic variant 323 NS primary 77 ENSP00000395243.3:p.Cys579Gly ENST00000454757.6:c.1735T>G 7:g.55165427T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003350-T01-IM5 2719841 2578662 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51815967 COSM39522 133205184 c.520T>G p.C174G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Cys174Gly ENST00000455089.5:c.520T>G 7:g.55152572T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A065-T-S18 2757403 2616000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000154-T01-IM3 2714713 2573534 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51819471 COSM6909030 132568040 c.1138A>C p.I380L Substitution - Missense het 38 7:55157728-55157728 + - PATHOGENIC .99224 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ile380Leu ENST00000454757.6:c.1138A>C 7:g.55157728A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD6112a 1480266 1403925 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51812104 COSM4384126 133242146 c.2413C>G p.H805D Substitution - Missense 38 7:55191797-55191797 + - PATHOGENIC .98487 Confirmed somatic variant 24030381 NS NS ENSP00000415559.1:p.His805Asp ENST00000455089.5:c.2413C>G 7:g.55191797C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-0670 2108025 1985886 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 132551880 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Thr218Pro ENST00000454757.6:c.652A>C 7:g.55154050A>C EGFR ENST00000275493.6 3633 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 99378340 c.2248G>C p.A750P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000275493.2:p.Ala750Pro ENST00000275493.6:c.2248G>C 7:g.55174785G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1472952 1472952 1396651 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51848710 COSM26438 132561077 c.2485G>A p.G829S Substitution - Missense 38 7:55191869-55191869 + - PATHOGENIC .98912 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000395243.3:p.Gly829Ser ENST00000454757.6:c.2485G>A 7:g.55191869G>A EGFR ENST00000275493.6 3633 3236 2811925 2811925 2668484 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51823614 COSM4170219 99373800 c.2255C>T p.S752F Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98332 Confirmed somatic variant 31534501 pleural effusion NS 61 ENSP00000275493.2:p.Ser752Phe ENST00000275493.6:c.2255C>T 7:g.55174792C>T EGFR ENST00000275493.6 3633 3236 1312378 1312378 1223287 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM24429 178380423 c.? p.E709G Substitution - Missense + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 51 ENSP00000275493.2:p.Glu709Gly EGFR ENST00000275493.6 3633 3236 2150413 2150413 2019482 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2150420 2150420 2019489 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 53 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EE-A29D-06 2121635 1995871 skin NS NS NS malignant_melanoma NS NS NS y COSV51799159 COSM747427 132570646 c.1631C>T p.P544L Substitution - Missense 38 7:55165323-55165323 + - PATHOGENIC .95834 Confirmed somatic variant 540 NS NS 87 ENSP00000395243.3:p.Pro544Leu ENST00000454757.6:c.1631C>T 7:g.55165323C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010967-T01-IM5 2726608 2585429 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51856949 COSM6978220 133277117 c.413G>T p.R138I Substitution - Missense het 38 7:55143477-55143477 + - PATHOGENIC .94211 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg138Ile ENST00000455089.5:c.413G>T 7:g.55143477G>T EGFR ENST00000275493.6 3633 3236 2591401 2591401 2452361 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-06-0649-01 1337849 1248234 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51791901 COSM2151461 99416512 c.991G>A p.G331R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .96902 Confirmed somatic variant 329 surgery fresh/frozen NS 73 ENSP00000275493.2:p.Gly331Arg ENST00000275493.6:c.991G>A 7:g.55155931G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 961769 961769 878053 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51865841 COSM14243 133276689 c.2099A>G p.K700R Substitution - Missense het 38 7:55174771-55174771 + - PATHOGENIC .99591 Confirmed somatic variant 16324836 fixed - NOS NS 72 ENSP00000415559.1:p.Lys700Arg ENST00000455089.5:c.2099A>G 7:g.55174771A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004837-T01-IM5 2721240 2580061 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51812540 COSM1451536 133222895 c.322A>G p.R108G Substitution - Missense het 38 7:55143386-55143386 + - PATHOGENIC .72671 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Arg108Gly ENST00000455089.5:c.322A>G 7:g.55143386A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-EE-A2M7-06 2121673 1995909 skin NS NS NS malignant_melanoma NS NS NS y COSV51790699 COSM3639729 133227375 c.656G>A p.C219Y Substitution - Missense 38 7:55154054-55154054 + - PATHOGENIC .99369 Confirmed somatic variant 540 NS NS 66 ENSP00000415559.1:p.Cys219Tyr ENST00000455089.5:c.656G>A 7:g.55154054G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006029-T01-IM5 2722410 2581231 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51862288 COSM6947601 132583027 c.2599T>G p.S867A Substitution - Missense het 38 7:55198749-55198749 + - PATHOGENIC .906 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Ser867Ala ENST00000454757.6:c.2599T>G 7:g.55198749T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000154-T01-IM3 2714713 2573534 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51819471 COSM6909030 133224992 c.1138A>C p.I380L Substitution - Missense het 38 7:55157728-55157728 + - PATHOGENIC .99224 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ile380Leu ENST00000455089.5:c.1138A>C 7:g.55157728A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0013704-T01-IM5 2803863 2660613 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51781835 COSM174732 132552286 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 29316426 surgery-fixed primary 71 ENSP00000395243.3:p.Glu114Lys ENST00000454757.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1022 2491916 2354545 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS y COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 26437033 surgery fresh/frozen NS 55 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 P-0000785-T01-IM3 2715984 2574805 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767730 COSM6548312 99381402 c.662G>T p.G221V Substitution - Missense het 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly221Val ENST00000275493.6:c.662G>T 7:g.55152579G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005511-T01-IM5 2721903 2580724 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51836402 COSM6944131 133222597 c.2219C>G p.T740S Substitution - Missense het 38 7:55181363-55181363 + - PATHOGENIC .951 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Thr740Ser ENST00000455089.5:c.2219C>G 7:g.55181363C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876654 2876654 2731169 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 circulating tumour NS 63 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811952 2811952 2668493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 31534501 pleural effusion NS 69 ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832120 COSM6493935 99420070 c.2386G>C p.G796R Substitution - Missense 38 7:55181395-55181395 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000275493.2:p.Gly796Arg ENST00000275493.6:c.2386G>C 7:g.55181395G>C EGFR ENST00000275493.6 3633 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105110312 COSM9869917 99412251 c.2152C>G p.L718V Substitution - Missense 38 7:55174011-55174011 + Yes PATHOGENIC .92276 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000275493.2:p.Leu718Val ENST00000275493.6:c.2152C>G 7:g.55174011C>G EGFR ENST00000275493.6 3633 3236 P-0010634-T01-IM5 2726322 2585143 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51847135 COSM6975718 99438798 c.3209G>C p.S1070T Substitution - Missense het 38 7:55202563-55202563 + - PATHOGENIC .94366 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ser1070Thr ENST00000275493.6:c.3209G>C 7:g.55202563G>C EGFR ENST00000275493.6 3633 3236 2876611 2876611 2731126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105110312 COSM9869917 99412251 c.2152C>G p.L718V Substitution - Missense 38 7:55174011-55174011 + Yes PATHOGENIC .92276 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000275493.2:p.Leu718Val ENST00000275493.6:c.2152C>G 7:g.55174011C>G EGFR ENST00000275493.6 3633 3236 1468656 1468656 1392407 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152756 2152756 2021766 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51845233 COSM3734669 132553198 c.2083A>G p.I695V Substitution - Missense 38 7:55174755-55174755 + - PATHOGENIC .99591 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Ile695Val ENST00000454757.6:c.2083A>G 7:g.55174755A>G EGFR ENST00000275493.6 3633 3236 P-0006960-T01-IM5 2723335 2582156 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51787507 COSM13188 99385457 c.2281G>A p.D761N Substitution - Missense het 38 7:55174818-55174818 + - PATHOGENIC .99476 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Asp761Asn ENST00000275493.6:c.2281G>A 7:g.55174818G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Br306T 1313064 1223973 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 surgery - NOS primary 51 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010754-T01-IM5 2726435 2585256 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51805749 COSM6976991 132548558 c.2509G>A p.A837T Substitution - Missense het 38 7:55192784-55192784 + - PATHOGENIC .95513 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala837Thr ENST00000454757.6:c.2509G>A 7:g.55192784G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD23564a 2213146 2081276 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV51788393 COSM13979 133219516 c.2035G>A p.G679S Substitution - Missense 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 27135926 NS NS ENSP00000415559.1:p.Gly679Ser ENST00000455089.5:c.2035G>A 7:g.55174029G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM_IV-35 2354292 2218450 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577028 COSM9413137 132621887 c.1337T>A p.I446K Substitution - Missense 38 7:55160312-55160312 + - NEUTRAL .08768 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000395243.3:p.Ile446Lys ENST00000454757.6:c.1337T>A 7:g.55160312T>A EGFR ENST00000275493.6 3633 3236 2625889 2625889 2486301 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51800917 COSM6191460 99396938 c.2027A>G p.K676R Substitution - Missense 38 7:55173090-55173090 + - PATHOGENIC .99801 Confirmed somatic variant 25617745 surgery-fixed NS 47 ENSP00000275493.2:p.Lys676Arg ENST00000275493.6:c.2027A>G 7:g.55173090A>G EGFR ENST00000275493.6 3633 3236 P-0004225-T01-IM5 2720632 2579453 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV51771772 COSM6934070 99459709 c.1299T>A p.H433Q Substitution - Missense het 38 7:55160139-55160139 + - PATHOGENIC .93122 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.His433Gln ENST00000275493.6:c.1299T>A 7:g.55160139T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD42110c 2894819 2749307 skin extremity NS NS malignant_melanoma nodular NS NS y COSV51822879 COSM4680399 132555327 c.1904G>A p.R635Q Substitution - Missense 38 7:55173102-55173102 + - PATHOGENIC .99814 Confirmed somatic variant 33024263 surgery-fixed metastasis ENSP00000395243.3:p.Arg635Gln ENST00000454757.6:c.1904G>A 7:g.55173102G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 945536 945536 862171 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51788393 COSM13979 132563273 c.2035G>A p.G679S Substitution - Missense het 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 16166444 surgery-fixed primary 57 ENSP00000395243.3:p.Gly679Ser ENST00000454757.6:c.2035G>A 7:g.55174029G>A EGFR ENST00000275493.6 3633 3236 P-0002329-T01-IM3 2718615 2577436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2591401 2591401 2452361 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1235342 178378585 c.? p.L62R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu62Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982863 982863 898582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1790518 1790518 1693497 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM7-I1 2813443 2669835 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489246 1489246 1412404 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811960 2811960 2668496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed NS 78 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004979 1004979 922191 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A014-T-S44 2758138 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152798 2152798 2021808 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001707-T01-IM3 2717834 2576655 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_C35 1863716 1754607 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460135 1460135 1384012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1044284 1044284 960625 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876058 2876058 2730573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 56 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004991 1004991 922203 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458682 1458682 1382657 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A014-T-S39 2758137 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LICA-CN-HCC131T 2634178 2494574 liver NS NS NS other neoplasm NS NS y COSV51799496 COSM5824594 99404323 c.244A>T p.I82F Substitution - Missense 38 7:55143308-55143308 + - PATHOGENIC .99415 Confirmed somatic variant 660 NS primary 49 ENSP00000275493.2:p.Ile82Phe ENST00000275493.6:c.244A>T 7:g.55143308A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876602 2876602 2731117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 132560202 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 57 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-GF-A6C9-06 2339468 2204451 skin NS NS NS malignant_melanoma NS NS NS y COSV51778029 COSM6268 132554063 c.2122C>T p.P708S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Confirmed somatic variant 540 NS NS 78 ENSP00000395243.3:p.Pro708Ser ENST00000454757.6:c.2122C>T 7:g.55174794C>T EGFR ENST00000275493.6 3633 3236 P-0003175-T01-IM5 2719668 2578489 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51836358 COSM6926707 99459903 c.2058G>C p.R686S Substitution - Missense het 38 7:55173121-55173121 + - PATHOGENIC .86375 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Arg686Ser ENST00000275493.6:c.2058G>C 7:g.55173121G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-0670-01 2178104 2046402 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 133206822 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 NS NS 60 ENSP00000415559.1:p.Thr218Pro ENST00000455089.5:c.652A>C 7:g.55154050A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003393-T01-IM5 2829603 2685418 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51792310 COSM6928197 133209757 c.50C>T p.A17V Substitution - Missense 38 7:55019327-55019327 + - NEUTRAL .01177 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000415559.1:p.Ala17Val ENST00000455089.5:c.50C>T 7:g.55019327C>T EGFR ENST00000275493.6 3633 3236 GBM7-I2 2813444 2669836 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99293015 COSM9210724 99398643 c.1871G>C p.C624S Substitution - Missense 38 7:55165428-55165428 + - PATHOGENIC .99908 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000275493.2:p.Cys624Ser ENST00000275493.6:c.1871G>C 7:g.55165428G>C EGFR ENST00000275493.6 3633 3236 P-0006622-T01-IM5 2829996 2685811 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51845994 COSM5530405 99374106 c.1633G>A p.E545K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 30205045 surgery-fixed primary 43 ENSP00000275493.2:p.Glu545Lys ENST00000275493.6:c.1633G>A 7:g.55163734G>A EGFR ENST00000275493.6 3633 3236 1438353 1438353 1346127 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 99378740 c.2582T>G p.L861R Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 20823418 surgery fresh/frozen primary 76 ENSP00000275493.2:p.Leu861Arg ENST00000275493.6:c.2582T>G 7:g.55191831T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2492701 2492701 2355316 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 132569945 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000395243.3:p.His47Tyr ENST00000454757.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982779 982779 898498 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51865051 COSM18442 132611125 c.2106_2109delinsCCCG p.L702_R703delinsFP Substitution - Missense 38 7:55174778-55174781 + - Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu702_Arg703delinsPhePro ENST00000454757.6:c.2106_2109delinsCCCG 7:g.55174778_55174781delinsCCCG EGFR ENST00000275493.6 3633 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 99390660 c.1391C>T p.S464L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000275493.2:p.Ser464Leu ENST00000275493.6:c.1391C>T 7:g.55160231C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876591 2876591 2731106 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 132560202 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 74 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2757166 2757166 2615808 haematopoietic_and_lymphoid_tissue skin NS NS lymphoid_neoplasm mycosis_fungoides-Sezary_syndrome NS NS y COSV104576496 COSM9308820 132591768 c.1111G>A p.D371N Substitution - Missense 38 7:55157701-55157701 + - PATHOGENIC .96223 Confirmed somatic variant 26551670 blood-bone marrow secondary ENSP00000395243.3:p.Asp371Asn ENST00000454757.6:c.1111G>A 7:g.55157701G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DY-A1DF-01 1651675 1566462 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51776282 COSM1168015 132547141 c.2123C>T p.P708L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Confirmed somatic variant 375 NS primary 73 ENSP00000395243.3:p.Pro708Leu ENST00000454757.6:c.2123C>T 7:g.55174795C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458689 1458689 1382664 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0006541-T01-IM5 2722916 2581737 NS NS NS NS malignant_melanoma NS NS NS n COSV51823220 COSM13179 99386001 c.2080C>T p.P694S Substitution - Missense het 38 7:55173939-55173939 + - PATHOGENIC .97389 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Pro694Ser ENST00000275493.6:c.2080C>T 7:g.55173939C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A114-T-S43 2757428 2616005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 61 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1179547 1179547 1091509 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152767 2152767 2021777 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004794 1004794 922006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16140420 surgery - NOS primary 53 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-62-8394-01 2194776 2063054 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 65 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 YUKLAB 2013569 1896201 skin NS NS NS malignant_melanoma NS NS NS y COSV51796177 COSM1698689 99420789 c.1189A>T p.T397S Substitution - Missense het 38 7:55156814-55156814 + - PATHOGENIC .9893 Confirmed somatic variant 22842228 surgery fresh/frozen metastasis 84 ENSP00000275493.2:p.Thr397Ser ENST00000275493.6:c.1189A>T 7:g.55156814A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 B103-S1 2732514 2591270 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV104576423 COSM9498532 133211437 c.1566G>T p.M522I Substitution - Missense 38 7:55163802-55163802 + - PATHOGENIC .93931 Confirmed somatic variant 29244145 surgery fresh/frozen primary 74.3 ENSP00000415559.1:p.Met522Ile ENST00000455089.5:c.1566G>T 7:g.55163802G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM18-I2 2813454 2669846 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769451 COSM26036 132598302 c.2471A>G p.Y824C Substitution - Missense 38 7:55191855-55191855 + - PATHOGENIC .986 Confirmed somatic variant 28263318 surgery fresh/frozen NS 40 ENSP00000395243.3:p.Tyr824Cys ENST00000454757.6:c.2471A>G 7:g.55191855A>G EGFR ENST00000275493.6 3633 3236 1589269 1589269 1510423 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51843707 COSM28601 99378273 c.2135T>C p.F712S Substitution - Missense 38 7:55173994-55173994 + - PATHOGENIC .9621 Confirmed somatic variant 22026926 surgery fresh/frozen NS ENSP00000275493.2:p.Phe712Ser ENST00000275493.6:c.2135T>C 7:g.55173994T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008346-T01-IM5 2830127 2685942 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51838649 COSM6962468 133243598 c.412A>G p.R138G Substitution - Missense 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 30205045 surgery-fixed primary 61 ENSP00000415559.1:p.Arg138Gly ENST00000455089.5:c.412A>G 7:g.55143476A>G EGFR ENST00000275493.6 3633 3236 GBM_IV-35 2354292 2218450 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 P-0003350-T01-IM5 2719841 2578662 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51815967 COSM39522 99377187 c.655T>G p.C219G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Cys219Gly ENST00000275493.6:c.655T>G 7:g.55152572T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM7-I2 2813444 2669836 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 123 2748095 2606798 stomach NS NS NS carcinoma NS NS NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 683 NS primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576891 COSM9396331 132561609 c.1265A>C p.K422T Substitution - Missense 38 7:55160240-55160240 + - NEUTRAL .10442 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000395243.3:p.Lys422Thr ENST00000454757.6:c.1265A>C 7:g.55160240A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GCTK_424_T 2747457 2606160 stomach NS NS NS carcinoma NS NS NS y COSV99292647 COSM8533690 133223971 c.2282A>C p.K761T Substitution - Missense 38 7:55181426-55181426 + - PATHOGENIC .92579 Confirmed somatic variant 683 NS primary ENSP00000415559.1:p.Lys761Thr ENST00000455089.5:c.2282A>C 7:g.55181426A>C EGFR ENST00000275493.6 3633 3236 P-0005127-T01-IM5 2721532 2580353 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51800313 COSM5608354 99376626 c.2272G>A p.E758K Substitution - Missense het 38 7:55174809-55174809 + - PATHOGENIC .99476 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Glu758Lys ENST00000275493.6:c.2272G>A 7:g.55174809G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920109 920109 837188 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51862985 COSM13431 132613391 c.2402A>G p.K801R Substitution - Missense het 38 7:55191786-55191786 + - PATHOGENIC .97673 Confirmed somatic variant 15623594 surgery-fixed NS 60 ENSP00000395243.3:p.Lys801Arg ENST00000454757.6:c.2402A>G 7:g.55191786A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-A6S1-01 2263260 2130244 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 329 NS primary 53 ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577027 COSM9413135 133220677 c.1259G>A p.G420E Substitution - Missense 38 7:55160234-55160234 + - NEUTRAL .11765 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000415559.1:p.Gly420Glu ENST00000455089.5:c.1259G>A 7:g.55160234G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM18-I2 2813454 2669846 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769451 COSM26036 133262088 c.2471A>G p.Y824C Substitution - Missense 38 7:55191855-55191855 + - PATHOGENIC .986 Confirmed somatic variant 28263318 surgery fresh/frozen NS 40 ENSP00000415559.1:p.Tyr824Cys ENST00000455089.5:c.2471A>G 7:g.55191855A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S06-38853-TP 2366573 2229456 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51792018 COSM4992972 133206283 c.2999C>T p.S1000F Substitution - Missense het 38 7:55201754-55201754 + - PATHOGENIC .97067 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000415559.1:p.Ser1000Phe ENST00000455089.5:c.2999C>T 7:g.55201754C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876052 2876052 2730567 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 78 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PC-9ER 2015225 1897433 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 23733853 cell-line NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 IGC-10-1053 2662337 2522461 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51767730 COSM6548312 99381402 c.662G>T p.G221V Substitution - Missense 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000275493.2:p.Gly221Val ENST00000275493.6:c.662G>T 7:g.55152579G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 R056-R1 2813482 2669874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289246 COSM8268187 132551517 c.653C>T p.T218I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 42 ENSP00000395243.3:p.Thr218Ile ENST00000454757.6:c.653C>T 7:g.55154051C>T EGFR ENST00000275493.6 3633 3236 TCGA-12-3650-01 2120284 1994520 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51845825 COSM3412188 99385017 c.1280G>T p.R427L Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .99702 Confirmed somatic variant 329 NS NS 46 ENSP00000275493.2:p.Arg427Leu ENST00000275493.6:c.1280G>T 7:g.55157735G>T EGFR ENST00000275493.6 3633 3236 YUSCO 2013686 1896318 skin NS NS NS malignant_melanoma NS NS NS y COSV51778830 COSM1698691 99378942 c.1198G>A p.E400K Substitution - Missense het 38 7:55156823-55156823 + - PATHOGENIC .99571 Confirmed somatic variant 22842228 NS NS ENSP00000275493.2:p.Glu400Lys ENST00000275493.6:c.1198G>A 7:g.55156823G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD8733a 1588462 1509633 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia_with_ringed_sideroblasts NS n COSV51795335 COSM53232 132581114 c.1987A>G p.K663E Substitution - Missense 38 7:55173981-55173981 + - PATHOGENIC .98155 Confirmed somatic variant 24030381 NS NS ENSP00000395243.3:p.Lys663Glu ENST00000454757.6:c.1987A>G 7:g.55173981A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM7-I2 2813444 2669836 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99293015 COSM9210724 132567311 c.1736G>C p.C579S Substitution - Missense 38 7:55165428-55165428 + - PATHOGENIC .99908 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000395243.3:p.Cys579Ser ENST00000454757.6:c.1736G>C 7:g.55165428G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001247 1001247 918470 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920029 920029 837108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 40 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 896925 896925 814548 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982881 982881 898600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1179552 1179552 1091514 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005114-T01-IM5 2721517 2580338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1109718 1109718 1023628 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 88 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206767 1206767 1118645 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001256 1001256 918479 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004981 1004981 922193 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577024 COSM9413134 99460426 c.1322T>A p.V441D Substitution - Missense 38 7:55160162-55160162 + - PATHOGENIC .92743 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000275493.2:p.Val441Asp ENST00000275493.6:c.1322T>A 7:g.55160162T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-EE-A29D-06 2121635 1995871 skin NS NS NS malignant_melanoma NS NS NS y COSV51799159 COSM747427 133228317 c.1631C>T p.P544L Substitution - Missense 38 7:55165323-55165323 + - PATHOGENIC .95834 Confirmed somatic variant 540 NS NS 87 ENSP00000415559.1:p.Pro544Leu ENST00000455089.5:c.1631C>T 7:g.55165323C>T EGFR ENST00000275493.6 3633 3236 TCSR-T 2823142 2678996 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 28818608 surgery fresh/frozen NS 49 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD42110c 2894819 2749307 skin extremity NS NS malignant_melanoma nodular NS NS y COSV51822879 COSM4680399 133211230 c.1904G>A p.R635Q Substitution - Missense 38 7:55173102-55173102 + - PATHOGENIC .99814 Confirmed somatic variant 33024263 surgery-fixed metastasis ENSP00000415559.1:p.Arg635Gln ENST00000455089.5:c.1904G>A 7:g.55173102G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000657-T02-IM5 2719370 2578191 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 132564457 c.1658G>C p.G553A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Gly553Ala ENST00000454757.6:c.1658G>C 7:g.55165350G>C EGFR ENST00000275493.6 3633 3236 P-0001328-T01-IM3 2717084 2575905 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1211140 1211140 1123008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471554 1471554 1395293 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0011038-T01-IM5 2726676 2585497 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982883 982883 898602 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A014-T-S52 2758140 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-28-5209-01 2120334 1994570 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51808387 COSM3412196 99393769 c.1793G>C p.G598A Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 329 NS NS 66 ENSP00000275493.2:p.Gly598Ala ENST00000275493.6:c.1793G>C 7:g.55165350G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-RD-A7BT-01 2263044 2130028 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99295752 COSM8178996 132570717 c.580G>A p.G194S Substitution - Missense 38 7:55152632-55152632 + - PATHOGENIC .99504 Confirmed somatic variant 541 NS primary 66 ENSP00000395243.3:p.Gly194Ser ENST00000454757.6:c.580G>A 7:g.55152632G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 16678 1423698 1333726 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51812036 COSM48318 132601198 c.1654G>A p.A552T Substitution - Missense het 38 7:55165346-55165346 + - NEUTRAL .27484 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Ala552Thr ENST00000454757.6:c.1654G>A 7:g.55165346G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008262-T01-IM5 2724401 2583222 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-19-1789-01 2178219 2046517 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51850088 COSM2156010 132570613 c.865C>T p.R289C Substitution - Missense 38 7:55155940-55155940 + - PATHOGENIC .91604 Confirmed somatic variant 329 NS NS 69 ENSP00000395243.3:p.Arg289Cys ENST00000454757.6:c.865C>T 7:g.55155940C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577026 COSM9413136 133285181 c.1258G>C p.G420R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .4176 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000415559.1:p.Gly420Arg ENST00000455089.5:c.1258G>C 7:g.55160233G>C EGFR ENST00000275493.6 3633 3236 CRC396 2730836 2589605 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV105863800 COSM10061888 99386028 c.1982C>G p.A661G Substitution - Missense 38 7:55173045-55173045 + - .53009 Confirmed somatic variant 26416732 xenograft metastasis 57 ENSP00000275493.2:p.Ala661Gly ENST00000275493.6:c.1982C>G 7:g.55173045C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0125-02 2120245 1994481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 64 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-26-1439-01 2120320 1994556 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 63 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T3174 2658322 2518481 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 132556268 c.1445G>A p.R482Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 74.41 ENSP00000395243.3:p.Arg482Gln ENST00000454757.6:c.1445G>A 7:g.55161580G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194735 1194735 1106630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-16-0849-01 2178109 2046407 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 54 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-2565-01 1337884 1248269 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772147 COSM375343 133220930 c.1799C>G p.S600C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000415559.1:p.Ser600Cys ENST00000455089.5:c.1799C>G 7:g.55172997C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211136 1211136 1123004 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 53 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004695-T01-IM5 2721097 2579918 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-WS012-T3 2869949 2724946 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110652 COSM9809446 132617389 c.2620C>T p.P874S Substitution - Missense 38 7:55198770-55198770 + - PATHOGENIC .97205 Confirmed somatic variant 26950094 surgery - NOS NS 82 ENSP00000395243.3:p.Pro874Ser ENST00000454757.6:c.2620C>T 7:g.55198770C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 171T 2473937 2336707 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 26489445 fixed - NOS NS ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 2150409 2150409 2019478 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 64 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2150412 2150412 2019481 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 P-0001328-T01-IM3 2717084 2575905 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 98019 1520664 1443039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51786915 COSM94179 132559530 c.475G>A p.E159K Substitution - Missense 38 7:55151344-55151344 + - NEUTRAL .0681 Confirmed somatic variant 20668451 NS primary ENSP00000395243.3:p.Glu159Lys ENST00000454757.6:c.475G>A 7:g.55151344G>A EGFR ENST00000275493.6 3633 3236 1211140 1211140 1123008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 54 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0005059-T01-IM5 2721463 2580284 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 IGC-02-1054 2662276 2522400 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51834398 COSM6536253 99459341 c.3279A>G p.I1093M Substitution - Missense 38 7:55205263-55205263 + - NEUTRAL .43211 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000275493.2:p.Ile1093Met ENST00000275493.6:c.3279A>G 7:g.55205263A>G EGFR ENST00000275493.6 3633 3236 P-0005370-T01-IM5 2721774 2580595 skin NS NS NS malignant_melanoma NS NS NS n COSV51794869 COSM4362780 99376586 c.574C>T p.P192S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Pro192Ser ENST00000275493.6:c.574C>T 7:g.55151308C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1284797 1284797 1196075 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51821681 COSM12989 132559479 c.2168G>A p.S723N Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98539 Confirmed somatic variant 19786660 surgery-fixed NS ENSP00000395243.3:p.Ser723Asn ENST00000454757.6:c.2168G>A 7:g.55181312G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM7-I1 2813443 2669835 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772147 COSM375343 132564558 c.1799C>G p.S600C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000395243.3:p.Ser600Cys ENST00000454757.6:c.1799C>G 7:g.55172997C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001262 1001262 918485 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 2901990 2901990 2756229 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM5010368 178378709 c.? p.C797S Substitution - Missense + Yes Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Cys797Ser EGFR ENST00000275493.6 3633 3236 TCSR-T 2823142 2678996 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 28818608 surgery fresh/frozen NS 49 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 70 2605252 2466143 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 25376516 surgery - NOS NS 68 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005127-T01-IM5 2721532 2580353 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51802355 COSM6941144 133204776 c.1019C>T p.P340L Substitution - Missense het 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Pro340Leu ENST00000455089.5:c.1019C>T 7:g.55156779C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008346-T01-IM5 2830127 2685942 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51838649 COSM6962468 132582557 c.412A>G p.R138G Substitution - Missense 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 30205045 surgery-fixed primary 61 ENSP00000395243.3:p.Arg138Gly ENST00000454757.6:c.412A>G 7:g.55143476A>G EGFR ENST00000275493.6 3633 3236 TCGA-AX-A06F-01 2198328 2066606 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51827490 COSM39163 99397529 c.1907G>A p.C636Y Substitution - Missense 38 7:55171201-55171201 + - PATHOGENIC .98251 Confirmed somatic variant 419 NS NS 59 ENSP00000275493.2:p.Cys636Tyr ENST00000275493.6:c.1907G>A 7:g.55171201G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001328-T01-IM3 2717084 2575905 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005059-T01-IM5 2721463 2580284 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211140 1211140 1123008 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 54 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 HCC827 2776313 2634449 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS y COSV51789379 COSM4362784 133221688 c.2102A>C p.E701A Substitution - Missense 38 7:55174774-55174774 + - PATHOGENIC .97548 Confirmed somatic variant 29681454 NS NS 38 ENSP00000415559.1:p.Glu701Ala ENST00000455089.5:c.2102A>C 7:g.55174774A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008145-T01-IM5 2724309 2583130 breast NS NS NS carcinoma NS NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 TCGA-16-0849-01 2178109 2046407 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 54 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 1194735 1194735 1106630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 007 2640411 2500713 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS y COSV51815598 COSM6471954 133220741 c.1190G>T p.S397I Substitution - Missense 38 7:55160165-55160165 + - NEUTRAL .44157 Confirmed somatic variant 27545006 fixed - NOS NS 57 ENSP00000415559.1:p.Ser397Ile ENST00000455089.5:c.1190G>T 7:g.55160165G>T EGFR ENST00000275493.6 3633 3236 R074-R1 2813496 2669888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99297135 COSM9212199 99396720 c.865G>T p.A289S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 41 ENSP00000275493.2:p.Ala289Ser ENST00000275493.6:c.865G>T 7:g.55154128G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1894611 1894611 1783303 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51837887 COSM1238071 132620158 c.1978A>G p.R660G Substitution - Missense hom 38 7:55173972-55173972 + - PATHOGENIC .89723 Confirmed somatic variant 23578570 surgery-fixed NS 33 ENSP00000395243.3:p.Arg660Gly ENST00000454757.6:c.1978A>G 7:g.55173972A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001262 1001262 918485 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2150409 2150409 2019478 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 64 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1312397 1312397 1223306 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 58 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625889 2625889 2486301 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51800917 COSM6191460 133222873 c.1892A>G p.K631R Substitution - Missense 38 7:55173090-55173090 + - PATHOGENIC .99801 Confirmed somatic variant 25617745 surgery-fixed NS 47 ENSP00000415559.1:p.Lys631Arg ENST00000455089.5:c.1892A>G 7:g.55173090A>G EGFR ENST00000275493.6 3633 3236 P-0004837-T01-IM5 2721240 2580061 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51812540 COSM1451536 99396971 c.322A>G p.R108G Substitution - Missense het 38 7:55143386-55143386 + - PATHOGENIC .72671 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Arg108Gly ENST00000275493.6:c.322A>G 7:g.55143386A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876593 2876593 2731108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 132560202 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2254T>A 7:g.55181398T>A EGFR ENST00000275493.6 3633 3236 P-0002329-T01-IM3 2718615 2577436 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CC28 2766422 2624641 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV99034446 COSM7342224 132578951 c.2286C>A p.D762E Substitution - Missense 38 7:55181430-55181430 + - PATHOGENIC .94178 Confirmed somatic variant 29844865 surgery fresh/frozen NS 56 ENSP00000395243.3:p.Asp762Glu ENST00000454757.6:c.2286C>A 7:g.55181430C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Br302T 1313062 1223971 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51803656 COSM39614 132550878 c.2769C>G p.F923L Substitution - Missense het 38 7:55200371-55200371 + - PATHOGENIC .95135 Confirmed somatic variant 18772396 surgery - NOS primary 61 ENSP00000395243.3:p.Phe923Leu ENST00000454757.6:c.2769C>G 7:g.55200371C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EA-A410-01 2262924 2129908 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51769145 COSM3266559 132580106 c.739G>A p.V247M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 415 NS primary 51 ENSP00000395243.3:p.Val247Met ENST00000454757.6:c.739G>A 7:g.55154137G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832120 COSM6493935 133245088 c.2251G>C p.G751R Substitution - Missense 38 7:55181395-55181395 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000415559.1:p.Gly751Arg ENST00000455089.5:c.2251G>C 7:g.55181395G>C EGFR ENST00000275493.6 3633 3236 587342 1766789 1671109 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51777851 COSM1205052 99395067 c.494G>A p.R165Q Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .0375 Confirmed somatic variant 22895193 surgery fresh/frozen primary ENSP00000275493.2:p.Arg165Gln ENST00000275493.6:c.494G>A 7:g.55146675G>A EGFR ENST00000275493.6 3633 3236 1458697 1458697 1382672 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A062-T-S27 2757400 2615999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152763 2152763 2021773 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0006139-T01-IM5 2722519 2581340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471553 1471553 1395292 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1460156 1460156 1384033 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152758 2152758 2021768 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004706-T01-IM5 2721110 2579931 eye uveal_tract NS NS malignant_melanoma NS NS NS n COSV51862598 COSM6938266 133202738 c.1889G>A p.R630Q Substitution - Missense het 38 7:55173087-55173087 + - PATHOGENIC .98305 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Arg630Gln ENST00000455089.5:c.1889G>A 7:g.55173087G>A EGFR ENST00000275493.6 3633 3236 TCGA-AX-A06F-01 2198328 2066606 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99294241 COSM8943299 99416803 c.710C>A p.A237D Substitution - Missense 38 7:55152627-55152627 + - PATHOGENIC .99353 Confirmed somatic variant 419 NS NS 59 ENSP00000275493.2:p.Ala237Asp ENST00000275493.6:c.710C>A 7:g.55152627C>A EGFR ENST00000275493.6 3633 3236 SJERG020309_D1 2565683 2427077 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51802051 COSM5986345 99421004 c.1993G>A p.G665S Substitution - Missense 38 7:55173056-55173056 + - PATHOGENIC .98464 Confirmed somatic variant 27776115 blood-bone marrow primary 17.5 ENSP00000275493.2:p.Gly665Ser ENST00000275493.6:c.1993G>A 7:g.55173056G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD6780a 1503990 1426868 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia_with_ringed_sideroblasts NS n COSV51791654 COSM4384111 133242640 c.95A>G p.Q32R Substitution - Missense 38 7:55142292-55142292 + - PATHOGENIC .96882 Confirmed somatic variant 24030381 NS NS ENSP00000415559.1:p.Gln32Arg ENST00000455089.5:c.95A>G 7:g.55142292A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000785-T01-IM3 2715984 2574805 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767730 COSM6548312 133209712 c.527G>T p.G176V Substitution - Missense het 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly176Val ENST00000455089.5:c.527G>T 7:g.55152579G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625883 2625883 2486295 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51796381 COSM6191457 133261873 c.1732A>T p.N578Y Substitution - Missense 38 7:55165424-55165424 + - PATHOGENIC .99705 Confirmed somatic variant 25617745 surgery-fixed NS 61 ENSP00000415559.1:p.Asn578Tyr ENST00000455089.5:c.1732A>T 7:g.55165424A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD6883a 1504094 1426972 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia NS n COSV51850592 COSM4384117 132557412 c.619C>G p.R207G Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .93941 Confirmed somatic variant 24030381 NS NS ENSP00000395243.3:p.Arg207Gly ENST00000454757.6:c.619C>G 7:g.55154017C>G EGFR ENST00000275493.6 3633 3236 2901989 2901989 2756229 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 Br306T 1313064 1223973 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 surgery - NOS primary 51 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2876611 2876611 2731126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0006210-T01-IM5 2722589 2581410 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2811980 2811980 2668502 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 circulating tumour NS 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458688 1458688 1382663 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 148 898384 815996 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0003116-T01-IM5 2719610 2578431 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876597 2876597 2731112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211145 1211145 1123013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 38 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000347-T01-IM3 2715085 2573906 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1472949 1472949 1396648 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51773206 COSM28603 99389206 c.2293G>A p.V765M Substitution - Missense 38 7:55181302-55181302 + - PATHOGENIC .97963 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000275493.2:p.Val765Met ENST00000275493.6:c.2293G>A 7:g.55181302G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006437-T01-IM5 2722813 2581634 skin NS NS NS adnexal_tumour malignant_adnexal_tumour NS NS n COSV51788796 COSM4680390 132569555 c.293G>A p.R98Q Substitution - Missense het 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg98Gln ENST00000454757.6:c.293G>A 7:g.55143357G>A EGFR ENST00000275493.6 3633 3236 96737 1973055 1859299 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSV51777851 COSM1205052 99395067 c.494G>A p.R165Q Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .0375 Confirmed somatic variant 23680147 surgery - NOS primary ENSP00000275493.2:p.Arg165Gln ENST00000275493.6:c.494G>A 7:g.55146675G>A EGFR ENST00000275493.6 3633 3236 1471544 1471544 1395283 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920032 920032 837111 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 76 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A001-T-S03 2757356 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458679 1458679 1382654 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152777 2152777 2021787 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0002534-T01-IM3 2718800 2577621 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1004810 1004810 922022 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16140420 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0007322-T01-IM5 2723661 2582482 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458683 1458683 1382658 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876659 2876659 2731174 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876652 2876652 2731167 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0001296-T01-IM3 2717010 2575831 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0001123-T02-IM5 2719395 2578216 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1001252 1001252 918475 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982884 982884 898603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0006437-T01-IM5 2722813 2581634 skin NS NS NS adnexal_tumour malignant_adnexal_tumour NS NS n COSV51788796 COSM4680390 99401501 c.293G>A p.R98Q Substitution - Missense het 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg98Gln ENST00000275493.6:c.293G>A 7:g.55143357G>A EGFR ENST00000275493.6 3633 3236 2152756 2152756 2021766 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51845233 COSM3734669 99380080 c.2218A>G p.I740V Substitution - Missense 38 7:55174755-55174755 + - PATHOGENIC .99591 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Ile740Val ENST00000275493.6:c.2218A>G 7:g.55174755A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51834362 COSM6503269 133213822 c.2018T>A p.L673Q Substitution - Missense 38 7:55174012-55174012 + Yes PATHOGENIC .96343 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000415559.1:p.Leu673Gln ENST00000455089.5:c.2018T>A 7:g.55174012T>A EGFR ENST00000275493.6 3633 3236 T521 2296252 2161855 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51822020 COSM4745530 99436523 c.2301_2302delinsGG p.S768G Substitution - Missense 38 7:55181310-55181311 + - Confirmed somatic variant 25344691 NS NS 62.83 ENSP00000275493.2:p.Ser768Gly ENST00000275493.6:c.2301_2302delinsGG 7:g.55181310_55181311delinsGG EGFR ENST00000275493.6 3633 3236 Br302T 1313062 1223971 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51803656 COSM39614 99377758 c.2904C>G p.F968L Substitution - Missense het 38 7:55200371-55200371 + - PATHOGENIC .95135 Confirmed somatic variant 18772396 surgery - NOS primary 61 ENSP00000275493.2:p.Phe968Leu ENST00000275493.6:c.2904C>G 7:g.55200371C>G EGFR ENST00000275493.6 3633 3236 2876611 2876611 2731126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876049 2876049 2730564 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 44 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2492723 2492723 2355338 skin NS NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 132556505 c.2890G>A p.D964N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000395243.3:p.Asp964Asn ENST00000454757.6:c.2890G>A 7:g.55201266G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002709-T01-IM3 2718949 2577770 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51766357 COSM6924089 132604777 c.2893G>T p.V965L Substitution - Missense het 38 7:55201269-55201269 + - PATHOGENIC .82061 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Val965Leu ENST00000454757.6:c.2893G>T 7:g.55201269G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FR-A8YC-06 2263445 2130429 skin NS NS NS malignant_melanoma NS NS NS y COSV51772860 COSM5872872 132580122 c.548C>T p.P183L Substitution - Missense 38 7:55152600-55152600 + - PATHOGENIC .99115 Confirmed somatic variant 540 NS NS 78 ENSP00000395243.3:p.Pro183Leu ENST00000454757.6:c.548C>T 7:g.55152600C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-CJ-4868-01 2120501 1994737 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51791922 COSM3366979 132577144 c.2377C>A p.L793M Substitution - Missense 38 7:55191761-55191761 + - PATHOGENIC .88511 Confirmed somatic variant 416 NS NS 42 ENSP00000395243.3:p.Leu793Met ENST00000454757.6:c.2377C>A 7:g.55191761C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AX-A06F-01 2198328 2066606 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51827490 COSM39163 133223244 c.1772G>A p.C591Y Substitution - Missense 38 7:55171201-55171201 + - PATHOGENIC .98251 Confirmed somatic variant 419 NS NS 59 ENSP00000415559.1:p.Cys591Tyr ENST00000455089.5:c.1772G>A 7:g.55171201G>A EGFR ENST00000275493.6 3633 3236 2876652 2876652 2731167 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 67 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1211130 1211130 1122998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen metastasis 59 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876613 2876613 2731128 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T197 2658249 2518408 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51792018 COSM4992972 132551365 c.2999C>T p.S1000F Substitution - Missense 38 7:55201754-55201754 + - PATHOGENIC .97067 Confirmed somatic variant 27149842 NS NS 67.58 ENSP00000395243.3:p.Ser1000Phe ENST00000454757.6:c.2999C>T 7:g.55201754C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM7-I2 2813444 2669836 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99293015 COSM9210724 133224013 c.1736G>C p.C579S Substitution - Missense 38 7:55165428-55165428 + - PATHOGENIC .99908 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000415559.1:p.Cys579Ser ENST00000455089.5:c.1736G>C 7:g.55165428G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2749088 2749088 2607791 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51779794 COSM53264 132559797 c.2039C>T p.T680M Substitution - Missense 38 7:55174033-55174033 + - PATHOGENIC .97744 Confirmed somatic variant 29360550 surgery-fixed NS 67 ENSP00000395243.3:p.Thr680Met ENST00000454757.6:c.2039C>T 7:g.55174033C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1713239 1713239 1620973 pleura NS NS NS mesothelioma epithelial NS NS n COSV51779794 COSM53264 132559797 c.2039C>T p.T680M Substitution - Missense het 38 7:55174033-55174033 + - PATHOGENIC .97744 Confirmed somatic variant 22412050 surgery-fixed NS 59 ENSP00000395243.3:p.Thr680Met ENST00000454757.6:c.2039C>T 7:g.55174033C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876652 2876652 2731167 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 67 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211130 1211130 1122998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen metastasis 59 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 PD24225a 2234144 2101649 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV51817351 COSM3881830 99397516 c.3092G>A p.R1031Q Substitution - Missense 38 7:55201333-55201333 + - PATHOGENIC .98371 Confirmed somatic variant 652 NS NS ENSP00000275493.2:p.Arg1031Gln ENST00000275493.6:c.3092G>A 7:g.55201333G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876611 2876611 2731126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 50 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876049 2876049 2730564 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 44 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-XR-A8TF-01 2457496 2320333 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV99288624 COSM8419655 132582799 c.3349A>T p.S1117C Substitution - Missense 38 7:55205468-55205468 + - NEUTRAL .21616 Confirmed somatic variant 628 NS primary 74 ENSP00000395243.3:p.Ser1117Cys ENST00000454757.6:c.3349A>T 7:g.55205468A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003425-T01-IM5 2719907 2578728 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 133205223 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000415559.1:p.Ala244Asp ENST00000455089.5:c.731C>A 7:g.55154129C>A EGFR ENST00000275493.6 3633 3236 1001262 1001262 918485 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2115530 2115530 1989774 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1054302 1054302 970373 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 17409862 surgery - NOS primary 46 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 R074-R1 2813496 2669888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 41 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2115501 2115501 1989745 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003393-T01-IM5 2719877 2578698 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51792310 COSM6928197 133209757 c.50C>T p.A17V Substitution - Missense het 38 7:55019327-55019327 + - NEUTRAL .01177 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ala17Val ENST00000455089.5:c.50C>T 7:g.55019327C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008145-T01-IM5 2724309 2583130 breast NS NS NS carcinoma NS NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1120295 1120295 1033451 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51774569 COSM27096 132583855 c.2899G>C p.D967H Substitution - Missense 38 7:55201275-55201275 + - PATHOGENIC .99621 Confirmed somatic variant 18478265 surgery fresh/frozen NS ENSP00000395243.3:p.Asp967His ENST00000454757.6:c.2899G>C 7:g.55201275G>C EGFR ENST00000275493.6 3633 3236 2150410 2150410 2019479 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 45 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591441 2591441 2452401 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 19T 2745856 2604559 liver NS NS NS other neoplasm NS NS y COSV51840438 COSM1727959 99395756 c.374A>G p.Y125C Substitution - Missense 38 7:55143438-55143438 + - PATHOGENIC .99088 Confirmed somatic variant 660 NS primary 71 ENSP00000275493.2:p.Tyr125Cys ENST00000275493.6:c.374A>G 7:g.55143438A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1505362 1505362 1428240 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51779291 COSM26446 132560907 c.2389A>G p.N797D Substitution - Missense 38 7:55191773-55191773 + - PATHOGENIC .986 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000395243.3:p.Asn797Asp ENST00000454757.6:c.2389A>G 7:g.55191773A>G EGFR ENST00000275493.6 3633 3236 2492723 2492723 2355338 skin NS NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 99383908 c.3025G>A p.D1009N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000275493.2:p.Asp1009Asn ENST00000275493.6:c.3025G>A 7:g.55201266G>A EGFR ENST00000275493.6 3633 3236 1317186 1317186 1228087 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20126411 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1516753 1516753 1439347 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21575252 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 GBM7-I1 2813443 2669835 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772147 COSM375343 99393933 c.1934C>G p.S645C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000275493.2:p.Ser645Cys ENST00000275493.6:c.1934C>G 7:g.55172997C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005051-T01-IM5 2721455 2580276 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 16678 1423698 1333726 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51812036 COSM48318 99442099 c.1789G>A p.A597T Substitution - Missense het 38 7:55165346-55165346 + - NEUTRAL .27484 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Ala597Thr ENST00000275493.6:c.1789G>A 7:g.55165346G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008246-T02-IM5 2724392 2583213 skin NS NS NS malignant_melanoma NS NS NS n COSV51776967 COSM6963220 132562155 c.1795C>T p.P599S Substitution - Missense het 38 7:55172993-55172993 + - PATHOGENIC .96242 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Pro599Ser ENST00000454757.6:c.1795C>T 7:g.55172993C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A014-T-S47 2758139 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471558 1471558 1395297 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 XHDG25C 2321255 2186409 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV51811244 COSM4767521 99378712 c.607G>A p.G203R Substitution - Missense 38 7:55151341-55151341 + - PATHOGENIC .99471 Confirmed somatic variant 24997986 NS NS 77 ENSP00000275493.2:p.Gly203Arg ENST00000275493.6:c.607G>A 7:g.55151341G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625883 2625883 2486295 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51796371 COSM6191453 132598162 c.203C>T p.T68I Substitution - Missense 38 7:55142400-55142400 + - PATHOGENIC .99116 Confirmed somatic variant 25617745 surgery-fixed NS 61 ENSP00000395243.3:p.Thr68Ile ENST00000454757.6:c.203C>T 7:g.55142400C>T EGFR ENST00000275493.6 3633 3236 M692PT 2671812 2531371 pleura NS NS NS mesothelioma epithelial NS NS n COSV51783428 COSM6848064 99390890 c.2930G>A p.R977H Substitution - Missense 38 7:55200397-55200397 + - PATHOGENIC .99379 Confirmed somatic variant 26928227 surgery fresh/frozen primary 69 ENSP00000275493.2:p.Arg977His ENST00000275493.6:c.2930G>A 7:g.55200397G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000922-T01-IM3 2716264 2575085 skin NS NS NS malignant_melanoma NS NS NS n COSV51862272 COSM6913539 132598705 c.2567G>A p.G856E Substitution - Missense het 38 7:55198717-55198717 + - PATHOGENIC .99414 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Gly856Glu ENST00000454757.6:c.2567G>A 7:g.55198717G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S001073 1027682 944658 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 2150410 2150410 2019479 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 45 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2115511 2115511 1989755 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0006119-T01-IM5 2722498 2581319 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51836444 COSM6948255 99445189 c.496G>A p.D166N Substitution - Missense het 38 7:55146677-55146677 + - PATHOGENIC .99816 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Asp166Asn ENST00000275493.6:c.496G>A 7:g.55146677G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 42 897188 814811 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489254 1489254 1412412 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460154 1460154 1384031 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152761 2152761 2021771 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920018 920018 837097 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876654 2876654 2731169 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 63 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152768 2152768 2021778 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010836-T01-IM5 2726504 2585325 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-3650-01 2120284 1994520 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51845825 COSM3412188 133213578 c.1145G>T p.R382L Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .99702 Confirmed somatic variant 329 NS NS 46 ENSP00000415559.1:p.Arg382Leu ENST00000455089.5:c.1145G>T 7:g.55157735G>T EGFR ENST00000275493.6 3633 3236 P-0000657-T02-IM5 2719370 2578191 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 99393769 c.1793G>C p.G598A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Gly598Ala ENST00000275493.6:c.1793G>C 7:g.55165350G>C EGFR ENST00000275493.6 3633 3236 1790527 1790527 1693506 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51815927 COSM24971 99392587 c.2513T>C p.L838P Substitution - Missense 38 7:55191762-55191762 + - PATHOGENIC .97813 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000275493.2:p.Leu838Pro ENST00000275493.6:c.2513T>C 7:g.55191762T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914581 914581 832030 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 132549057 c.2183A>T p.H728L Substitution - Missense het 38 7:55181327-55181327 + - PATHOGENIC .98404 Confirmed somatic variant 15788655 surgery fresh/frozen primary 72 ENSP00000395243.3:p.His728Leu ENST00000454757.6:c.2183A>T 7:g.55181327A>T EGFR ENST00000275493.6 3633 3236 961769 961769 878053 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51865841 COSM14243 99452968 c.2234A>G p.K745R Substitution - Missense het 38 7:55174771-55174771 + - PATHOGENIC .99591 Confirmed somatic variant 16324836 fixed - NOS NS 72 ENSP00000275493.2:p.Lys745Arg ENST00000275493.6:c.2234A>G 7:g.55174771A>G EGFR ENST00000275493.6 3633 3236 98019 1520664 1443039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51786915 COSM94179 99387546 c.610G>A p.E204K Substitution - Missense 38 7:55151344-55151344 + - NEUTRAL .0681 Confirmed somatic variant 20668451 NS primary ENSP00000275493.2:p.Glu204Lys ENST00000275493.6:c.610G>A 7:g.55151344G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MTP18_T2 2875798 2730360 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 32796935 surgery-fixed NS 74 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2503528 2503528 2365878 autonomic_ganglia sinonasal_and_nasal_cavity NS NS olfactory_neuroblastoma NS NS NS n COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense het 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 27149458 surgery - NOS NS 44 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 123 2748095 2606798 stomach NS NS NS carcinoma NS NS NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 683 NS primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 GBM7-I2 2813444 2669836 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AM-5820-01 1651150 1565937 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 376 NS NS 59 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1109720 1109720 1023630 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 18372921 surgery-fixed primary 72 ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CRC177post 2730751 2589520 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51776247 COSM6110417 132563707 c.1258G>A p.G420R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Confirmed somatic variant 26416732 xenograft metastasis 59 ENSP00000395243.3:p.Gly420Arg ENST00000454757.6:c.1258G>A 7:g.55160233G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CS1-C 2898363 2752647 endometrium NS NS NS carcinoma carcinosarcoma-malignant_mesodermal_mixed_tumour NS NS y COSV51806667 COSM6987130 132569004 c.1804G>A p.A602T Substitution - Missense 38 7:55173002-55173002 + - PATHOGENIC .99609 Confirmed somatic variant 33021035 surgery fresh/frozen NS 84 ENSP00000395243.3:p.Ala602Thr ENST00000454757.6:c.1804G>A 7:g.55173002G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003955-T01-IM3 2719291 2578112 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51841887 COSM6949297 133221673 c.1819G>A p.G607R Substitution - Missense het 38 7:55173017-55173017 + - PATHOGENIC .99728 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly607Arg ENST00000455089.5:c.1819G>A 7:g.55173017G>A EGFR ENST00000275493.6 3633 3236 GBM7-I1 2813443 2669835 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002964-T02-IM3 2719172 2577993 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51843252 COSM6925373 132590293 c.2887G>T p.D963Y Substitution - Missense het 38 7:55201263-55201263 + - PATHOGENIC .98531 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Asp963Tyr ENST00000454757.6:c.2887G>T 7:g.55201263G>T EGFR ENST00000275493.6 3633 3236 171T 2473937 2336707 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 26489445 fixed - NOS NS ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-76-4927-01 2120379 1994615 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 58 ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MELA_20076 2760731 2619264 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 132553183 c.1033C>A p.Q345K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 30178487 surgery fresh/frozen metastasis 30 ENSP00000395243.3:p.Gln345Lys ENST00000454757.6:c.1033C>A 7:g.55156793C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EE-A3AB-06 2121693 1995929 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 132553183 c.1033C>A p.Q345K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 540 NS NS 30 ENSP00000395243.3:p.Gln345Lys ENST00000454757.6:c.1033C>A 7:g.55156793C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005114-T01-IM5 2721517 2580338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51817830 COSM6941076 132574341 c.2465A>C p.K822T Substitution - Missense het 38 7:55191849-55191849 + - PATHOGENIC .9501 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Lys822Thr ENST00000454757.6:c.2465A>C 7:g.55191849A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920111 920111 837190 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 15623594 surgery-fixed NS 66 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876623 2876623 2731138 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 29506987 circulating tumour NS 86 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD8934a 1595624 1516507 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51847987 COSM4384128 133214675 c.2731G>A p.D911N Substitution - Missense 38 7:55200333-55200333 + - PATHOGENIC .99504 Confirmed somatic variant 24030381 NS NS ENSP00000415559.1:p.Asp911Asn ENST00000455089.5:c.2731G>A 7:g.55200333G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 WGC003608 2785119 2645235 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS y COSV99286188 COSM7420903 133258322 c.1435G>T p.V479F Substitution - Missense 38 7:55161570-55161570 + - .6767 Confirmed somatic variant 25526346 surgery fresh/frozen primary 54 ENSP00000415559.1:p.Val479Phe ENST00000455089.5:c.1435G>T 7:g.55161570G>T EGFR ENST00000275493.6 3633 3236 1468560 1468560 1392311 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Gly719Cys EGFR ENST00000275493.6 3633 3236 1004793 1004793 922005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM20881 178378330 c.? p.G719C Substitution - Missense + - Confirmed somatic variant 16140420 surgery - NOS primary 61 ENSP00000275493.2:p.Gly719Cys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 ESCC_74 2479576 2342336 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51766168 COSM1716256 132551981 c.2093C>T p.A698V Substitution - Missense 38 7:55174765-55174765 + - PATHOGENIC .99382 Confirmed somatic variant 26873401 NS NS 61 ENSP00000395243.3:p.Ala698Val ENST00000454757.6:c.2093C>T 7:g.55174765C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 IGC-10-1053 2662337 2522461 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51767730 COSM6548312 133209712 c.527G>T p.G176V Substitution - Missense 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000415559.1:p.Gly176Val ENST00000455089.5:c.527G>T 7:g.55152579G>T EGFR ENST00000275493.6 3633 3236 P-0008262-T01-IM5 2724401 2583222 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 18195 2422953 2285875 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV51779680 COSM1313184 133232489 c.1016C>G p.T339S Substitution - Missense 38 7:55156776-55156776 + - PATHOGENIC .98418 Confirmed somatic variant 24469795 NS NS 61 ENSP00000415559.1:p.Thr339Ser ENST00000455089.5:c.1016C>G 7:g.55156776C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 99 2630349 2490733 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51802602 COSM13181 132564438 c.2063C>T p.P688L Substitution - Missense 38 7:55174735-55174735 + - PATHOGENIC .99806 Confirmed somatic variant 27756406 surgery-fixed metastasis 61 ENSP00000395243.3:p.Pro688Leu ENST00000454757.6:c.2063C>T 7:g.55174735C>T EGFR ENST00000275493.6 3633 3236 5-WS012-T3 2869949 2724946 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110652 COSM9809446 99456683 c.2755C>T p.P919S Substitution - Missense 38 7:55198770-55198770 + - PATHOGENIC .97205 Confirmed somatic variant 26950094 surgery - NOS NS 82 ENSP00000275493.2:p.Pro919Ser ENST00000275493.6:c.2755C>T 7:g.55198770C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T1803 2658686 2518845 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51850996 COSM6652242 132562694 c.1057G>A p.V353I Substitution - Missense 38 7:55156817-55156817 + - PATHOGENIC .99161 Confirmed somatic variant 27149842 NS NS 63 ENSP00000395243.3:p.Val353Ile ENST00000454757.6:c.1057G>A 7:g.55156817G>A EGFR ENST00000275493.6 3633 3236 2503528 2503528 2365878 autonomic_ganglia sinonasal_and_nasal_cavity NS NS olfactory_neuroblastoma NS NS NS n COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense het 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 27149458 surgery - NOS NS 44 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 TCGA-AM-5820-01 1651150 1565937 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 376 NS NS 59 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 MTP18_T2 2875798 2730360 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 32796935 surgery-fixed NS 74 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-5413-01 2120265 1994501 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51805324 COSM3412202 133264032 c.2392G>C p.V798L Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .99128 Confirmed somatic variant 329 NS NS 67 ENSP00000415559.1:p.Val798Leu ENST00000455089.5:c.2392G>C 7:g.55191776G>C EGFR ENST00000275493.6 3633 3236 TCGA-14-2554-01 1338017 1248402 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 52 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM_IV-35 2354292 2218450 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AA-3982-01 1651089 1565876 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51769747 COSM297803 133236604 c.772G>C p.D258H Substitution - Missense 38 7:55155847-55155847 + - PATHOGENIC .99461 Confirmed somatic variant 22810696 376 NS NS 75 ENSP00000415559.1:p.Asp258His ENST00000455089.5:c.772G>C 7:g.55155847G>C EGFR ENST00000275493.6 3633 3236 TCGA-AA-3982-01 1651089 1565876 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51769747 COSM297803 99409471 c.907G>C p.D303H Substitution - Missense 38 7:55155847-55155847 + - PATHOGENIC .99461 Confirmed somatic variant 22810696 376 NS NS 75 ENSP00000275493.2:p.Asp303His ENST00000275493.6:c.907G>C 7:g.55155847G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010130-T01-IM5 2725937 2584758 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51788796 COSM4680390 132569555 c.293G>A p.R98Q Substitution - Missense het 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Arg98Gln ENST00000454757.6:c.293G>A 7:g.55143357G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004104-T01-IM5 2829691 2685506 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51846321 COSM6933335 132607120 c.1773T>G p.C591W Substitution - Missense 38 7:55171202-55171202 + - .63273 Confirmed somatic variant 30205045 surgery-fixed metastasis 32 ENSP00000395243.3:p.Cys591Trp ENST00000454757.6:c.1773T>G 7:g.55171202T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2625883 2625883 2486295 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51796381 COSM6191457 132598169 c.1732A>T p.N578Y Substitution - Missense 38 7:55165424-55165424 + - PATHOGENIC .99705 Confirmed somatic variant 25617745 surgery-fixed NS 61 ENSP00000395243.3:p.Asn578Tyr ENST00000454757.6:c.1732A>T 7:g.55165424A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A017-T-S16 2757377 2615994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 56 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 IGC-04-1168 2662309 2522433 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152771 2152771 2021781 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 961851 961851 878135 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16467080 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489242 1489242 1412400 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 65 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489244 1489244 1412402 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460151 1460151 1384028 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006054-T01-IM5 2722434 2581255 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 P-0010130-T01-IM5 2725937 2584758 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51788796 COSM4680390 99401501 c.293G>A p.R98Q Substitution - Missense het 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Arg98Gln ENST00000275493.6:c.293G>A 7:g.55143357G>A EGFR ENST00000275493.6 3633 3236 99 2630349 2490733 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51802602 COSM13181 99393727 c.2198C>T p.P733L Substitution - Missense 38 7:55174735-55174735 + - PATHOGENIC .99806 Confirmed somatic variant 27756406 surgery-fixed metastasis 61 ENSP00000275493.2:p.Pro733Leu ENST00000275493.6:c.2198C>T 7:g.55174735C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EXTERN_MELA_20140514_002 2839308 2695074 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51866168 COSM3266611 133224058 c.1705G>A p.G569S Substitution - Missense 38 7:55165397-55165397 + - NEUTRAL .00559 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000415559.1:p.Gly569Ser ENST00000455089.5:c.1705G>A 7:g.55165397G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-C5-A1BM-01 2193409 2061687 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51807983 COSM4826463 132594228 c.2297C>G p.S766C Substitution - Missense 38 7:55181441-55181441 + - PATHOGENIC .97792 Confirmed somatic variant 415 NS NS 78 ENSP00000395243.3:p.Ser766Cys ENST00000454757.6:c.2297C>G 7:g.55181441C>G EGFR ENST00000275493.6 3633 3236 2675084 2675084 2534359 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 29110836 surgery-fixed recurrent 66 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2625883 2625883 2486295 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51796381 COSM6191457 99438943 c.1867A>T p.N623Y Substitution - Missense 38 7:55165424-55165424 + - PATHOGENIC .99705 Confirmed somatic variant 25617745 surgery-fixed NS 61 ENSP00000275493.2:p.Asn623Tyr ENST00000275493.6:c.1867A>T 7:g.55165424A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1894611 1894611 1783303 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51837887 COSM1238071 133283354 c.1978A>G p.R660G Substitution - Missense hom 38 7:55173972-55173972 + - PATHOGENIC .89723 Confirmed somatic variant 23578570 surgery-fixed NS 33 ENSP00000415559.1:p.Arg660Gly ENST00000455089.5:c.1978A>G 7:g.55173972A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0012402-T01-IM5 2727458 2586279 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51850996 COSM6652242 132562694 c.1057G>A p.V353I Substitution - Missense het 38 7:55156817-55156817 + - PATHOGENIC .99161 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Val353Ile ENST00000454757.6:c.1057G>A 7:g.55156817G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-SL-A6JA-01 2386253 2249085 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99293220 COSM8830926 132585485 c.2420A>C p.K807T Substitution - Missense 38 7:55191804-55191804 + - PATHOGENIC .98276 Confirmed somatic variant 419 NS primary 77 ENSP00000395243.3:p.Lys807Thr ENST00000454757.6:c.2420A>C 7:g.55191804A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006029-T01-IM5 2722410 2581231 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51862288 COSM6947601 133244074 c.2599T>G p.S867A Substitution - Missense het 38 7:55198749-55198749 + - PATHOGENIC .906 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Ser867Ala ENST00000455089.5:c.2599T>G 7:g.55198749T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2772383 2772383 2630573 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV99290341 COSM7347800 132592803 c.881G>A p.G294E Substitution - Missense 38 7:55156542-55156542 + - PATHOGENIC .99668 Confirmed somatic variant 29807833 circulating tumour NS ENSP00000395243.3:p.Gly294Glu ENST00000454757.6:c.881G>A 7:g.55156542G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001248-T01-IM3 2716920 2575741 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51855488 COSM4166393 132562300 c.575C>T p.A192V Substitution - Missense het 38 7:55152627-55152627 + - PATHOGENIC .99229 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ala192Val ENST00000454757.6:c.575C>T 7:g.55152627C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003705-T01-IM5 2720193 2579014 large_intestine appendix NS NS carcinoma adenocarcinoma NS NS n COSV51812036 COSM48318 132601198 c.1654G>A p.A552T Substitution - Missense het 38 7:55165346-55165346 + - NEUTRAL .27484 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ala552Thr ENST00000454757.6:c.1654G>A 7:g.55165346G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1063624 1063624 979669 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S0361 897613 815236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15118125 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004982 1004982 922194 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A028-T-S18 2757395 2615998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004678-T01-IM5 2721078 2579899 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876667 2876667 2731182 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 71 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009623-T01-IM5 2725517 2584338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1001262 1001262 918485 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 S10-24679-TP 2366580 2229463 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51808100 COSM4992964 99447259 c.818C>T p.T273I Substitution - Missense het 38 7:55154081-55154081 + - PATHOGENIC .9224 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000275493.2:p.Thr273Ile ENST00000275493.6:c.818C>T 7:g.55154081C>T EGFR ENST00000275493.6 3633 3236 pfg043T 2309624 2174826 stomach NS NS NS carcinoma intestinal_adenocarcinoma NS NS y COSV51790826 COSM4755611 99378993 c.566A>C p.K189T Substitution - Missense het 38 7:55151300-55151300 + - PATHOGENIC .93585 Confirmed somatic variant 24816253 surgery fresh/frozen NS 76 ENSP00000275493.2:p.Lys189Thr ENST00000275493.6:c.566A>C 7:g.55151300A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2014_Lung_sq_06_T 2744877 2603580 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 77 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 RS33T 2653643 2513765 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS primary 67.09 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005378-T01-IM5 2721782 2580603 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51862161 COSM6943352 133202322 c.73C>G p.L25V Substitution - Missense het 38 7:55019350-55019350 + - NEUTRAL .21138 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Leu25Val ENST00000455089.5:c.73C>G 7:g.55019350C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003569-T01-IM5 2720054 2578875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004607-T02-IM5 2721004 2579825 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152760 2152760 2021770 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152789 2152789 2021799 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1468092 1468092 1391938 peritoneum NS NS NS mesothelioma NS NS NS n COSV51816047 COSM53101 133215679 c.2057G>T p.W686L Substitution - Missense het 38 7:55174729-55174729 + - PATHOGENIC .99891 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000415559.1:p.Trp686Leu ENST00000455089.5:c.2057G>T 7:g.55174729G>T EGFR ENST00000275493.6 3633 3236 P-0002614-T01-IM3 2718868 2577689 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense het 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576891 COSM9396331 99390041 c.1400A>C p.K467T Substitution - Missense 38 7:55160240-55160240 + - NEUTRAL .10442 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000275493.2:p.Lys467Thr ENST00000275493.6:c.1400A>C 7:g.55160240A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-GF-A6C9-06 2339468 2204451 skin NS NS NS malignant_melanoma NS NS NS y COSV51778029 COSM6268 133209348 c.2122C>T p.P708S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Confirmed somatic variant 540 NS NS 78 ENSP00000415559.1:p.Pro708Ser ENST00000455089.5:c.2122C>T 7:g.55174794C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002207-T01-IM3 2718499 2577320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152787 2152787 2021797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2812082 2812082 2668551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 99378340 c.2248G>C p.A750P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Confirmed somatic variant 31534501 pleural effusion NS 68 ENSP00000275493.2:p.Ala750Pro ENST00000275493.6:c.2248G>C 7:g.55174785G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206717 1206717 1118595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003316-T01-IM5 2719809 2578630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152784 2152784 2021794 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000785-T01-IM3 2715984 2574805 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DU-A5TY-01 2194202 2062480 central_nervous_system brain NS NS glioma NS NS NS y COSV51765881 COSM3929118 132597731 c.814G>A p.E272K Substitution - Missense 38 7:55155889-55155889 + - PATHOGENIC .99356 Confirmed somatic variant 545 NS NS 46 ENSP00000395243.3:p.Glu272Lys ENST00000454757.6:c.814G>A 7:g.55155889G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S001018 1027698 944674 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 1312390 1312390 1223299 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 50 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003417-T01-IM5 2719901 2578722 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS n COSV51815967 COSM39522 132550299 c.520T>G p.C174G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Cys174Gly ENST00000454757.6:c.520T>G 7:g.55152572T>G EGFR ENST00000275493.6 3633 3236 1312378 1312378 1223287 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 51 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1010432 1010432 927606 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 17001163 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005701-T01-IM5 2722086 2580907 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 TCGA-BR-4256-01 2198141 2066419 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51797215 COSM145360 99385818 c.967G>A p.V323I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 541 NS NS 80 ENSP00000275493.2:p.Val323Ile ENST00000275493.6:c.967G>A 7:g.55155907G>A EGFR ENST00000275493.6 3633 3236 GCTK_424_T 2747457 2606160 stomach NS NS NS carcinoma NS NS NS y COSV99292647 COSM8533690 99398572 c.2417A>C p.K806T Substitution - Missense 38 7:55181426-55181426 + - PATHOGENIC .92579 Confirmed somatic variant 683 NS primary ENSP00000275493.2:p.Lys806Thr ENST00000275493.6:c.2417A>C 7:g.55181426A>C EGFR ENST00000275493.6 3633 3236 PD42110c 2894819 2749307 skin extremity NS NS malignant_melanoma nodular NS NS y COSV105111084 COSM9905470 99412512 c.2020G>A p.V674I Substitution - Missense 38 7:55173083-55173083 + - PATHOGENIC .9014 Confirmed somatic variant 33024263 surgery-fixed metastasis ENSP00000275493.2:p.Val674Ile ENST00000275493.6:c.2020G>A 7:g.55173083G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-5413-01 2120265 1994501 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51805324 COSM3412202 99440828 c.2527G>C p.V843L Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .99128 Confirmed somatic variant 329 NS NS 67 ENSP00000275493.2:p.Val843Leu ENST00000275493.6:c.2527G>C 7:g.55191776G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-0670 2108025 1985886 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 133206822 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Thr218Pro ENST00000455089.5:c.652A>C 7:g.55154050A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S10-24679-TP 2366580 2229463 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51808100 COSM4992964 133270719 c.683C>T p.T228I Substitution - Missense het 38 7:55154081-55154081 + - PATHOGENIC .9224 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000415559.1:p.Thr228Ile ENST00000455089.5:c.683C>T 7:g.55154081C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-5413-01 2120265 1994501 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51805324 COSM3412202 132599942 c.2392G>C p.V798L Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .99128 Confirmed somatic variant 329 NS NS 67 ENSP00000395243.3:p.Val798Leu ENST00000454757.6:c.2392G>C 7:g.55191776G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004837-T01-IM5 2721240 2580061 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2625883 2625883 2486295 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51796371 COSM6191453 133261867 c.203C>T p.T68I Substitution - Missense 38 7:55142400-55142400 + - PATHOGENIC .99116 Confirmed somatic variant 25617745 surgery-fixed NS 61 ENSP00000415559.1:p.Thr68Ile ENST00000455089.5:c.203C>T 7:g.55142400C>T EGFR ENST00000275493.6 3633 3236 P-0011107-T01-IM5 2726736 2585557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DU-7292-01 2194421 2062699 central_nervous_system brain NS NS glioma NS NS NS y COSV51800797 COSM3412178 132557507 c.620G>C p.R207P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 545 NS NS 69 ENSP00000395243.3:p.Arg207Pro ENST00000454757.6:c.620G>C 7:g.55154018G>C EGFR ENST00000275493.6 3633 3236 1468654 1468654 1392405 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BR-4256-01 2198141 2066419 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51797215 COSM145360 133214261 c.832G>A p.V278I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 541 NS NS 80 ENSP00000415559.1:p.Val278Ile ENST00000455089.5:c.832G>A 7:g.55155907G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982774 982774 898493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 P-0007901-T01-IM5 2724112 2582933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2591403 2591403 2452363 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 P-0005051-T01-IM5 2721455 2580276 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002614-T01-IM3 2718868 2577689 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 RS33T 2653643 2513765 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS primary 67.09 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2014_Lung_sq_06_T 2744877 2603580 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 77 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 P-0001248-T01-IM3 2716920 2575741 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51855488 COSM4166393 99390906 c.710C>T p.A237V Substitution - Missense het 38 7:55152627-55152627 + - PATHOGENIC .99229 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ala237Val ENST00000275493.6:c.710C>T 7:g.55152627C>T EGFR ENST00000275493.6 3633 3236 1113155 1113155 1026656 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM27047 178387518 c.? p.H773_V774delinsLM Substitution - Missense + - Confirmed somatic variant 18450321 surgery - NOS NS ENSP00000275493.2:p.His773_Val774delinsLeuMet EGFR ENST00000275493.6 3633 3236 P-0006290-T01-IM5 2722667 2581488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51839751 COSM6949885 99393798 c.1926G>T p.K642N Substitution - Missense het 38 7:55172989-55172989 + - PATHOGENIC .95891 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Lys642Asn ENST00000275493.6:c.1926G>T 7:g.55172989G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-VS098-T1 2869935 2724932 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110457 COSM9807780 132574783 c.1030C>T p.P344S Substitution - Missense 38 7:55156790-55156790 + - PATHOGENIC .99297 Confirmed somatic variant 26950094 surgery - NOS NS 84 ENSP00000395243.3:p.Pro344Ser ENST00000454757.6:c.1030C>T 7:g.55156790C>T EGFR ENST00000275493.6 3633 3236 P-0008145-T01-IM5 2724309 2583130 breast NS NS NS carcinoma NS NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 2492701 2492701 2355316 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 99401924 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000275493.2:p.His47Tyr ENST00000275493.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1468093 1468093 1391939 peritoneum NS NS NS mesothelioma NS NS NS n COSV51847876 COSM53102 132607393 c.2065G>C p.E689Q Substitution - Missense het 38 7:55174737-55174737 + - PATHOGENIC .99895 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000395243.3:p.Glu689Gln ENST00000454757.6:c.2065G>C 7:g.55174737G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 M692PT 2671812 2531371 pleura NS NS NS mesothelioma epithelial NS NS n COSV51783428 COSM6848064 133218554 c.2795G>A p.R932H Substitution - Missense 38 7:55200397-55200397 + - PATHOGENIC .99379 Confirmed somatic variant 26928227 surgery fresh/frozen primary 69 ENSP00000415559.1:p.Arg932His ENST00000455089.5:c.2795G>A 7:g.55200397G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-MT-A67A-01 2193588 2061866 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51853450 COSM53290 133208421 c.2480A>G p.E827G Substitution - Missense 38 7:55191864-55191864 + - PATHOGENIC .986 Confirmed somatic variant 627 NS NS 85 ENSP00000415559.1:p.Glu827Gly ENST00000455089.5:c.2480A>G 7:g.55191864A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-16-0849-01 2178109 2046407 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 54 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194735 1194735 1106630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008927-T01-IM5 2724943 2583764 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51768139 COSM21685 133205223 c.731C>A p.A244D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Asp ENST00000455089.5:c.731C>A 7:g.55154129C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001042-T01-IM3 2716511 2575332 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1109718 1109718 1023628 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51780877 COSM26717 133203719 c.2444A>T p.K815I Substitution - Missense het 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 18372921 surgery-fixed primary 88 ENSP00000415559.1:p.Lys815Ile ENST00000455089.5:c.2444A>T 7:g.55191828A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005114-T01-IM5 2721517 2580338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780877 COSM26717 133203719 c.2444A>T p.K815I Substitution - Missense het 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Lys815Ile ENST00000455089.5:c.2444A>T 7:g.55191828A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006846-T01-IM5 2723226 2582047 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51781750 COSM6954369 132569998 c.819G>A p.M273I Substitution - Missense het 38 7:55155894-55155894 + - PATHOGENIC .91367 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Met273Ile ENST00000454757.6:c.819G>A 7:g.55155894G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006437-T01-IM5 2722813 2581634 skin NS NS NS adnexal_tumour malignant_adnexal_tumour NS NS n COSV51788796 COSM4680390 133226922 c.293G>A p.R98Q Substitution - Missense het 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg98Gln ENST00000455089.5:c.293G>A 7:g.55143357G>A EGFR ENST00000275493.6 3633 3236 1333486 1333486 1243960 kidney NS NS NS carcinoma papillary_renal_cell_carcinoma NS NS n COSM21945 178380161 c.? p.V802I Substitution - Missense + - Confirmed somatic variant 20346742 surgery - NOS metastasis 32 ENSP00000275493.2:p.Val802Ile EGFR ENST00000275493.6 3633 3236 R074-R1 2813496 2669888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 41 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 1472952 1472952 1396651 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51848710 COSM26438 99389356 c.2620G>A p.G874S Substitution - Missense 38 7:55191869-55191869 + - PATHOGENIC .98912 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000275493.2:p.Gly874Ser ENST00000275493.6:c.2620G>A 7:g.55191869G>A EGFR ENST00000275493.6 3633 3236 P-0003316-T01-IM5 2719809 2578630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 2811972 2811972 2668500 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 31534501 surgery-fixed metastasis 64 ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002580-T01-IM3 2718839 2577660 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TARGET-30-PALUDH-01A-01W 2195523 2063801 autonomic_ganglia NS NS NS neuroblastoma NS NS NS y COSV51767481 COSM1284692 132557901 c.1787C>A p.P596H Substitution - Missense 38 7:55172985-55172985 + - PATHOGENIC .97992 Confirmed somatic variant 584 NS NS ENSP00000395243.3:p.Pro596His ENST00000454757.6:c.1787C>A 7:g.55172985C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 D023M059 2788448 2645740 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSV51802272 COSM13425 132564786 c.2170G>A p.V724M Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .98024 Confirmed somatic variant 28120820 surgery-fixed metastasis ENSP00000395243.3:p.Val724Met ENST00000454757.6:c.2170G>A 7:g.55181314G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-IR-A3LA-01 2193391 2061669 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51796224 COSM4844514 132584404 c.1513G>C p.V505L Substitution - Missense 38 7:55163749-55163749 + - PATHOGENIC .98124 Confirmed somatic variant 415 NS NS 60 ENSP00000395243.3:p.Val505Leu ENST00000454757.6:c.1513G>C 7:g.55163749G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920037 920037 837116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 15623594 surgery fresh/frozen NS 76 ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BK0016 2237570 2105074 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51768262 COSM26445 132550179 c.2165C>T p.A722V Substitution - Missense 38 7:55181309-55181309 + - PATHOGENIC .97799 Confirmed somatic variant 24504440 surgery - NOS NS ENSP00000395243.3:p.Ala722Val ENST00000454757.6:c.2165C>T 7:g.55181309C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876045 2876045 2730560 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105111126 COSM9862211 132574528 c.1888C>T p.R630W Substitution - Missense 38 7:55173086-55173086 + - PATHOGENIC .96778 Confirmed somatic variant 29506987 NS recurrent 52 ENSP00000395243.3:p.Arg630Trp ENST00000454757.6:c.1888C>T 7:g.55173086C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001248-T01-IM3 2716920 2575741 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51855488 COSM4166393 133218567 c.575C>T p.A192V Substitution - Missense het 38 7:55152627-55152627 + - PATHOGENIC .99229 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ala192Val ENST00000455089.5:c.575C>T 7:g.55152627C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006119-T01-IM5 2722498 2581319 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51836484 COSM6948259 132604142 c.722G>A p.S241N Substitution - Missense het 38 7:55154120-55154120 + - PATHOGENIC .95351 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Ser241Asn ENST00000454757.6:c.722G>A 7:g.55154120G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003572-T01-IM5 2720057 2578878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 982791 982791 898510 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51779524 COSM18425 99379336 c.2156G>A p.G719D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Asp ENST00000275493.6:c.2156G>A 7:g.55174015G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-CV-7252-01 2193523 2061801 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 627 NS NS 62 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 P-0008145-T01-IM5 2724309 2583130 breast NS NS NS carcinoma NS NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009711-T01-IM5 2725587 2584408 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 EXTERN_MELA_20140514_002 2839308 2695074 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51866168 COSM3266611 99398718 c.1840G>A p.G614S Substitution - Missense 38 7:55165397-55165397 + - NEUTRAL .00559 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000275493.2:p.Gly614Ser ENST00000275493.6:c.1840G>A 7:g.55165397G>A EGFR ENST00000275493.6 3633 3236 1468647 1468647 1392398 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2035-ca 2823133 2678987 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 28818608 surgery-fixed NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0003393-T01-IM5 2829603 2685418 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51792310 COSM6928197 99381439 c.50C>T p.A17V Substitution - Missense 38 7:55019327-55019327 + - NEUTRAL .01177 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000275493.2:p.Ala17Val ENST00000275493.6:c.50C>T 7:g.55019327C>T EGFR ENST00000275493.6 3633 3236 PD23564a 2213146 2081276 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV51788393 COSM13979 99391974 c.2170G>A p.G724S Substitution - Missense 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 27135926 NS NS ENSP00000275493.2:p.Gly724Ser ENST00000275493.6:c.2170G>A 7:g.55174029G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002614-T01-IM3 2718868 2577689 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense het 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 99 2630349 2490733 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51802602 COSM13181 133220811 c.2063C>T p.P688L Substitution - Missense 38 7:55174735-55174735 + - PATHOGENIC .99806 Confirmed somatic variant 27756406 surgery-fixed metastasis 61 ENSP00000415559.1:p.Pro688Leu ENST00000455089.5:c.2063C>T 7:g.55174735C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005255 1005255 922467 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51773392 COSM20892 133254998 c.2276A>G p.E759G Substitution - Missense 38 7:55181420-55181420 + - PATHOGENIC .9793 Confirmed somatic variant 16720329 surgery-fixed primary 62 ENSP00000415559.1:p.Glu759Gly ENST00000455089.5:c.2276A>G 7:g.55181420A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 16678 1423698 1333726 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51812036 COSM48318 133265354 c.1654G>A p.A552T Substitution - Missense het 38 7:55165346-55165346 + - NEUTRAL .27484 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Ala552Thr ENST00000455089.5:c.1654G>A 7:g.55165346G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Br302T 1313062 1223971 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51803656 COSM39614 133205805 c.2769C>G p.F923L Substitution - Missense het 38 7:55200371-55200371 + - PATHOGENIC .95135 Confirmed somatic variant 18772396 surgery - NOS primary 61 ENSP00000415559.1:p.Phe923Leu ENST00000455089.5:c.2769C>G 7:g.55200371C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 AH29 2906938 2761105 endometrium NS NS NS hyperplasia atypical NS NS y COSV51832348 COSM6974705 132584044 c.3467C>T p.A1156V Substitution - Missense 38 7:55205586-55205586 + - PATHOGENIC .8173 Confirmed somatic variant 33016334 surgery-fixed NS ENSP00000395243.3:p.Ala1156Val ENST00000454757.6:c.3467C>T 7:g.55205586C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 17747 1423850 1333878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 TCGA-EE-A17X-06 2121618 1995854 skin NS NS NS malignant_melanoma NS NS NS y COSV51781835 COSM174732 99379122 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 540 NS NS 54 ENSP00000275493.2:p.Glu114Lys ENST00000275493.6:c.340G>A 7:g.55143404G>A EGFR ENST00000275493.6 3633 3236 1790518 1790518 1693497 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51844033 COSM707173 99400253 c.2273A>G p.E758G Substitution - Missense 38 7:55174810-55174810 + - PATHOGENIC .9946 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000275493.2:p.Glu758Gly ENST00000275493.6:c.2273A>G 7:g.55174810A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007018-T01-IM5 2723393 2582214 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765787 COSM2149971 133206295 c.775C>T p.H259Y Substitution - Missense het 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.His259Tyr ENST00000455089.5:c.775C>T 7:g.55155850C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CHC1774T 2340683 2205666 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51807517 COSM4802395 133252492 c.67C>T p.R23W Substitution - Missense 38 7:55019344-55019344 + - NEUTRAL .00803 Confirmed somatic variant 381 NS primary 65 ENSP00000415559.1:p.Arg23Trp ENST00000455089.5:c.67C>T 7:g.55019344C>T EGFR ENST00000275493.6 3633 3236 S001018 1027698 944674 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1194723 1194723 1106618 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51853292 COSM29339 132592258 c.271A>C p.I91L Substitution - Missense 38 7:55143335-55143335 + - PATHOGENIC .99037 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000395243.3:p.Ile91Leu ENST00000454757.6:c.271A>C 7:g.55143335A>C EGFR ENST00000275493.6 3633 3236 1005255 1005255 922467 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51773392 COSM20892 99431457 c.2411A>G p.E804G Substitution - Missense 38 7:55181420-55181420 + - PATHOGENIC .9793 Confirmed somatic variant 16720329 surgery-fixed primary 62 ENSP00000275493.2:p.Glu804Gly ENST00000275493.6:c.2411A>G 7:g.55181420A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011219-T01-IM5 2726835 2585656 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827895 COSM3412174 132552248 c.550A>T p.S184C Substitution - Missense het 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ser184Cys ENST00000454757.6:c.550A>T 7:g.55152602A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460101 1460101 1383978 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51799041 COSM52931 133235462 c.2060T>C p.I687T Substitution - Missense 38 7:55174732-55174732 + - PATHOGENIC .98814 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000415559.1:p.Ile687Thr ENST00000455089.5:c.2060T>C 7:g.55174732T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-15-0742-01 1338018 1248403 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51827490 COSM39163 132566663 c.1772G>A p.C591Y Substitution - Missense 38 7:55171201-55171201 + - PATHOGENIC .98251 Confirmed somatic variant 329 surgery fresh/frozen NS 65 ENSP00000395243.3:p.Cys591Tyr ENST00000454757.6:c.1772G>A 7:g.55171201G>A EGFR ENST00000275493.6 3633 3236 P-0008927-T01-IM5 2724943 2583764 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51767495 COSM35752 99380629 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg252Cys ENST00000275493.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-14-2554-01 1338017 1248402 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 52 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 95504 1973048 1859292 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSV51812284 COSM1651737 132588963 c.686C>T p.T229M Substitution - Missense 38 7:55154084-55154084 + - PATHOGENIC .92031 Confirmed somatic variant 23680147 surgery - NOS primary ENSP00000395243.3:p.Thr229Met ENST00000454757.6:c.686C>T 7:g.55154084C>T EGFR ENST00000275493.6 3633 3236 60 2699441 2558345 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51859123 COSM6906662 99406695 c.2038C>T p.R680W Substitution - Missense het 38 7:55173101-55173101 + - PATHOGENIC .98228 Confirmed somatic variant 29420467 surgery-fixed NS ENSP00000275493.2:p.Arg680Trp ENST00000275493.6:c.2038C>T 7:g.55173101C>T EGFR ENST00000275493.6 3633 3236 TCGA-DD-A73A-01 2194652 2062930 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51846765 COSM4916543 99381130 c.1232C>G p.P411R Substitution - Missense 38 7:55157687-55157687 + - PATHOGENIC .99735 Confirmed somatic variant 628 NS NS 71 ENSP00000275493.2:p.Pro411Arg ENST00000275493.6:c.1232C>G 7:g.55157687C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832145 COSM6493936 132574809 c.2254T>G p.C752G Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95801 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000395243.3:p.Cys752Gly ENST00000454757.6:c.2254T>G 7:g.55181398T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458703 1458703 1382678 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A021-T-S14 2757380 2615995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 57 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004691-T02-IM5 2721093 2579914 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982878 982878 898597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010345-T02-IM5 2726112 2584933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812108 2812108 2668564 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 59 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005016 1005016 922228 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 65 897198 814821 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CS1-C 2898363 2752647 endometrium NS NS NS carcinoma carcinosarcoma-malignant_mesodermal_mixed_tumour NS NS y COSV51806667 COSM6987130 133226220 c.1804G>A p.A602T Substitution - Missense 38 7:55173002-55173002 + - PATHOGENIC .99609 Confirmed somatic variant 33021035 surgery fresh/frozen NS 84 ENSP00000415559.1:p.Ala602Thr ENST00000455089.5:c.1804G>A 7:g.55173002G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 R074-R1 2813496 2669888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99297135 COSM9212199 133222727 c.730G>T p.A244S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 41 ENSP00000415559.1:p.Ala244Ser ENST00000455089.5:c.730G>T 7:g.55154128G>T EGFR ENST00000275493.6 3633 3236 S001071 1027700 944676 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 TCGA-EE-A2M7-06 2121673 1995909 skin NS NS NS malignant_melanoma NS NS NS y COSV51790699 COSM3639729 99401816 c.791G>A p.C264Y Substitution - Missense 38 7:55154054-55154054 + - PATHOGENIC .99369 Confirmed somatic variant 540 NS NS 66 ENSP00000275493.2:p.Cys264Tyr ENST00000275493.6:c.791G>A 7:g.55154054G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 88 2630342 2490726 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51769145 COSM3266559 132580106 c.739G>A p.V247M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 27756406 surgery-fixed primary 48 ENSP00000395243.3:p.Val247Met ENST00000454757.6:c.739G>A 7:g.55154137G>A EGFR ENST00000275493.6 3633 3236 P-0009711-T01-IM5 2725587 2584408 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AX-A06F-01 2198328 2066606 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99294241 COSM8943299 133242314 c.575C>A p.A192D Substitution - Missense 38 7:55152627-55152627 + - PATHOGENIC .99353 Confirmed somatic variant 419 NS NS 59 ENSP00000415559.1:p.Ala192Asp ENST00000455089.5:c.575C>A 7:g.55152627C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 17747 1423850 1333878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 982889 982889 898608 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 982888 982888 898607 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DU-A5TY-01 2194202 2062480 central_nervous_system brain NS NS glioma NS NS NS y COSV51765897 COSM3929120 132597743 c.826G>T p.D276Y Substitution - Missense 38 7:55155901-55155901 + - PATHOGENIC .95198 Confirmed somatic variant 545 NS NS 46 ENSP00000395243.3:p.Asp276Tyr ENST00000454757.6:c.826G>T 7:g.55155901G>T EGFR ENST00000275493.6 3633 3236 TCGA-06-A6S1-01 2263260 2130244 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 329 NS primary 53 ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002614-T01-IM3 2718868 2577689 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001971-T01-IM3 2718279 2577100 central_nervous_system brain NS NS glioma astrocytoma NS NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 TCGA-AR-A2LR-01 2187807 2056085 breast NS NS NS carcinoma NS NS NS y COSV51781835 COSM174732 99379122 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 414 NS NS 49 ENSP00000275493.2:p.Glu114Lys ENST00000275493.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006119-T01-IM5 2722498 2581319 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51836484 COSM6948259 133268700 c.722G>A p.S241N Substitution - Missense het 38 7:55154120-55154120 + - PATHOGENIC .95351 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Ser241Asn ENST00000455089.5:c.722G>A 7:g.55154120G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007994-T01-IM5 2724178 2582999 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51811471 COSM6960839 133243578 c.380C>A p.A127E Substitution - Missense het 38 7:55143444-55143444 + - NEUTRAL .44126 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ala127Glu ENST00000455089.5:c.380C>A 7:g.55143444C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Br306T 1313064 1223973 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 surgery - NOS primary 51 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-CN-4742-01 2193489 2061767 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825459 COSM122789 132558008 c.1288A>G p.I430V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Confirmed somatic variant 627 NS NS 48 ENSP00000395243.3:p.Ile430Val ENST00000454757.6:c.1288A>G 7:g.55160263A>G EGFR ENST00000275493.6 3633 3236 ESCC_74 2479576 2342336 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51766168 COSM1716256 99378822 c.2228C>T p.A743V Substitution - Missense 38 7:55174765-55174765 + - PATHOGENIC .99382 Confirmed somatic variant 26873401 NS NS 61 ENSP00000275493.2:p.Ala743Val ENST00000275493.6:c.2228C>T 7:g.55174765C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-OL-A97C-01 2386126 2248958 breast NS NS NS carcinoma NS NS NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 414 NS primary 67 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SF268 1998472 1883544 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 23856246 cell-line primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008927-T01-IM5 2724943 2583764 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51767495 COSM35752 133208833 c.619C>T p.R207C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg207Cys ENST00000455089.5:c.619C>T 7:g.55154017C>T EGFR ENST00000275493.6 3633 3236 TCGA-EE-A29D-06 2121635 1995871 skin NS NS NS malignant_melanoma NS NS NS y COSV51799159 COSM747427 99402636 c.1766C>T p.P589L Substitution - Missense 38 7:55165323-55165323 + - PATHOGENIC .95834 Confirmed somatic variant 540 NS NS 87 ENSP00000275493.2:p.Pro589Leu ENST00000275493.6:c.1766C>T 7:g.55165323C>T EGFR ENST00000275493.6 3633 3236 1894611 1894611 1783303 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51837871 COSM1238072 99459033 c.1636C>T p.P546S Substitution - Missense hom 38 7:55163737-55163737 + - PATHOGENIC .99252 Confirmed somatic variant 23578570 surgery-fixed NS 33 ENSP00000275493.2:p.Pro546Ser ENST00000275493.6:c.1636C>T 7:g.55163737C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-D3-A8GB-06 2262876 2129860 skin NS NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 132554177 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 540 NS NS 48 ENSP00000395243.3:p.Ser116Phe ENST00000454757.6:c.347C>T 7:g.55143411C>T EGFR ENST00000275493.6 3633 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577027 COSM9413135 99393507 c.1394G>A p.G465E Substitution - Missense 38 7:55160234-55160234 + - NEUTRAL .11765 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000275493.2:p.Gly465Glu ENST00000275493.6:c.1394G>A 7:g.55160234G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1468094 1468094 1391940 peritoneum NS NS NS mesothelioma NS NS NS n COSV51772198 COSM53103 132573399 c.2218A>G p.T740A Substitution - Missense het 38 7:55181362-55181362 + - PATHOGENIC .94016 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000395243.3:p.Thr740Ala ENST00000454757.6:c.2218A>G 7:g.55181362A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 245 898397 816009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 1005016 1005016 922228 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 1451153 1451153 1375296 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468631 1468631 1392382 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862413 2862413 2717596 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 31694833 surgery-fixed primary 58 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1502212 1502212 1425091 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21457545 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A062-T-S19 2757398 2615999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920034 920034 837113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 127 898383 815995 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489240 1489240 1412398 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 65 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004986 1004986 922198 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982852 982852 898571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1109742 1109742 1023652 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 54 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000352-T01-IM3 2715098 2573919 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003572-T01-IM5 2720057 2578878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982779 982779 898498 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51865051 COSM18442 133275344 c.2106_2109delinsCCCG p.L702_R703delinsFP Substitution - Missense 38 7:55174778-55174781 + - Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu702_Arg703delinsPhePro ENST00000455089.5:c.2106_2109delinsCCCG 7:g.55174778_55174781delinsCCCG EGFR ENST00000275493.6 3633 3236 1468615 1468615 1392366 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM53175 178381745 c.? p.I740T Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Ile740Thr EGFR ENST00000275493.6 3633 3236 2150406 2150406 2019475 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 24729716 surgery fresh/frozen primary 66 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591477 2591477 2452437 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 TCGA-EA-A410-01 2262924 2129908 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51769145 COSM3266559 99415380 c.874G>A p.V292M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 415 NS primary 51 ENSP00000275493.2:p.Val292Met ENST00000275493.6:c.874G>A 7:g.55154137G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001246 1001246 918469 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 P-0001971-T01-IM3 2718279 2577100 central_nervous_system brain NS NS glioma astrocytoma NS NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982869 982869 898588 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002403-T01-IM3 2718680 2577501 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876602 2876602 2731117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 57 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A065-T-S22 2757404 2616000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1322264 1322264 1233151 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 52 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489247 1489247 1412405 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0012076-T01-IM5 2727219 2586040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 APGI-AMP-2890 2866039 2721116 pancreas ampulla_of_Vater NS NS carcinoma ductal_carcinoma NS NS y COSV105111099 COSM9620623 132587507 c.526G>A p.G176R Substitution - Missense 38 7:55152578-55152578 + - NEUTRAL .36671 Confirmed somatic variant 26804919 surgery fresh/frozen NS ENSP00000395243.3:p.Gly176Arg ENST00000454757.6:c.526G>A 7:g.55152578G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 XHDG25C 2321255 2186409 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV51811244 COSM4767521 133206798 c.472G>A p.G158R Substitution - Missense 38 7:55151341-55151341 + - PATHOGENIC .99471 Confirmed somatic variant 24997986 NS NS 77 ENSP00000415559.1:p.Gly158Arg ENST00000455089.5:c.472G>A 7:g.55151341G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1284797 1284797 1196075 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51821681 COSM12989 133215634 c.2168G>A p.S723N Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98539 Confirmed somatic variant 19786660 surgery-fixed NS ENSP00000415559.1:p.Ser723Asn ENST00000455089.5:c.2168G>A 7:g.55181312G>A EGFR ENST00000275493.6 3633 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51776247 COSM6110417 99392696 c.1393G>A p.G465R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000275493.2:p.Gly465Arg ENST00000275493.6:c.1393G>A 7:g.55160233G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DU-7292-01 2194421 2062699 central_nervous_system brain NS NS glioma NS NS NS y COSV51800797 COSM3412178 133213607 c.620G>C p.R207P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 545 NS NS 69 ENSP00000415559.1:p.Arg207Pro ENST00000455089.5:c.620G>C 7:g.55154018G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577028 COSM9413137 133285200 c.1337T>A p.I446K Substitution - Missense 38 7:55160312-55160312 + - NEUTRAL .08768 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000415559.1:p.Ile446Lys ENST00000455089.5:c.1337T>A 7:g.55160312T>A EGFR ENST00000275493.6 3633 3236 TCGA-12-0670-01 2178104 2046402 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 99378725 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 NS NS 60 ENSP00000275493.2:p.Thr263Pro ENST00000275493.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010130-T01-IM5 2725937 2584758 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51788796 COSM4680390 133226922 c.293G>A p.R98Q Substitution - Missense het 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Arg98Gln ENST00000455089.5:c.293G>A 7:g.55143357G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-32-1991-01 2120347 1994583 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 60 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011107-T01-IM5 2726736 2585557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577024 COSM9413134 133285159 c.1187T>A p.V396D Substitution - Missense 38 7:55160162-55160162 + - PATHOGENIC .92743 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000415559.1:p.Val396Asp ENST00000455089.5:c.1187T>A 7:g.55160162T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-C5-A1BM-01 2193409 2061687 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51807972 COSM4826400 132594219 c.2232C>G p.I744M Substitution - Missense 38 7:55181376-55181376 + - PATHOGENIC .85141 Confirmed somatic variant 415 NS NS 78 ENSP00000395243.3:p.Ile744Met ENST00000454757.6:c.2232C>G 7:g.55181376C>G EGFR ENST00000275493.6 3633 3236 GBM18-I2 2813454 2669846 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769451 COSM26036 99439084 c.2606A>G p.Y869C Substitution - Missense 38 7:55191855-55191855 + - PATHOGENIC .986 Confirmed somatic variant 28263318 surgery fresh/frozen NS 40 ENSP00000275493.2:p.Tyr869Cys ENST00000275493.6:c.2606A>G 7:g.55191855A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MELA_20076 2760731 2619264 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 133208246 c.1033C>A p.Q345K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 30178487 surgery fresh/frozen metastasis 30 ENSP00000415559.1:p.Gln345Lys ENST00000455089.5:c.1033C>A 7:g.55156793C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-EE-A3AB-06 2121693 1995929 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 133208246 c.1033C>A p.Q345K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 540 NS NS 30 ENSP00000415559.1:p.Gln345Lys ENST00000455089.5:c.1033C>A 7:g.55156793C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0211-01 1910206 1798497 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 132551880 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 fresh/frozen - NOS primary 48 ENSP00000395243.3:p.Thr218Pro ENST00000454757.6:c.652A>C 7:g.55154050A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006960-T01-IM5 2723335 2582156 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51767379 COSM85894 133213549 c.2392G>A p.V798I Substitution - Missense het 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Val798Ile ENST00000455089.5:c.2392G>A 7:g.55191776G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471564 1471564 1395303 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812111 2812111 2668565 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 31534501 circulating tumour NS 73 ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FS-A1Z0-06 2121749 1995985 skin NS NS NS malignant_melanoma NS NS NS y COSV99293884 COSM7977358 132591645 c.3457C>A p.L1153I Substitution - Missense 38 7:55205576-55205576 + - PATHOGENIC .87661 Confirmed somatic variant 540 NS NS 32 ENSP00000395243.3:p.Leu1153Ile ENST00000454757.6:c.3457C>A 7:g.55205576C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876602 2876602 2731117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 57 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S_TBL200_R7 2757771 2616345 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29106415 autopsy - NOS metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2150406 2150406 2019475 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 66 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468635 1468635 1392386 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1002743 1002743 919960 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Confirmed somatic variant 16115929 surgery-fixed NS 61 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 P-0006054-T01-IM5 2722434 2581255 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 982779 982779 898498 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51865051 COSM18442 99451915 c.2241_2244delinsCCCG p.L747_R748delinsFP Substitution - Missense 38 7:55174778-55174781 + - Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu747_Arg748delinsPhePro ENST00000275493.6:c.2241_2244delinsCCCG 7:g.55174778_55174781delinsCCCG EGFR ENST00000275493.6 3633 3236 P-0003705-T01-IM5 2720193 2579014 large_intestine appendix NS NS carcinoma adenocarcinoma NS NS n COSV51812036 COSM48318 99442099 c.1789G>A p.A597T Substitution - Missense het 38 7:55165346-55165346 + - NEUTRAL .27484 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ala597Thr ENST00000275493.6:c.1789G>A 7:g.55165346G>A EGFR ENST00000275493.6 3633 3236 P-0011107-T01-IM5 2726736 2585557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0012043-T01-IM5 2727190 2586011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 007 2640411 2500713 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS y COSV51815598 COSM6471954 99393578 c.1325G>T p.S442I Substitution - Missense 38 7:55160165-55160165 + - NEUTRAL .44157 Confirmed somatic variant 27545006 fixed - NOS NS 57 ENSP00000275493.2:p.Ser442Ile ENST00000275493.6:c.1325G>T 7:g.55160165G>T EGFR ENST00000275493.6 3633 3236 2152767 2152767 2021777 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-62-8394-01 2194776 2063054 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 65 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1179547 1179547 1091509 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A114-T-S43 2757428 2616005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458689 1458689 1382664 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876058 2876058 2730573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 56 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876593 2876593 2731108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1004794 1004794 922006 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16140420 surgery - NOS primary 53 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000352-T01-IM3 2715098 2573919 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 1468095 1468095 1391941 peritoneum NS NS NS mesothelioma NS NS NS n COSV51818388 COSM53104 99406297 c.2390G>A p.C797Y Substitution - Missense het 38 7:55181399-55181399 + - PATHOGENIC .98244 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000275493.2:p.Cys797Tyr ENST00000275493.6:c.2390G>A 7:g.55181399G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010754-T01-IM5 2726435 2585256 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51805749 COSM6976991 133203538 c.2509G>A p.A837T Substitution - Missense het 38 7:55192784-55192784 + - PATHOGENIC .95513 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala837Thr ENST00000455089.5:c.2509G>A 7:g.55192784G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Pat_01_A 2492837 2355451 NS NS NS NS malignant_melanoma NS NS NS y COSV51817615 COSM5872885 132574294 c.2654G>A p.G885E Substitution - Missense 38 7:55198804-55198804 + - PATHOGENIC .99081 Confirmed somatic variant 24265153 surgery-fixed NS 45 ENSP00000395243.3:p.Gly885Glu ENST00000454757.6:c.2654G>A 7:g.55198804G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A014-T-S35 2758136 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CTS25 2393067 2255898 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 25189529 surgery fresh/frozen NS 67 ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A102-T-S33 2757414 2616002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471540 1471540 1395279 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CTS25 2393067 2255898 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0005114-T01-IM5 2721517 2580338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780877 COSM26717 99375410 c.2579A>T p.K860I Substitution - Missense het 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Lys860Ile ENST00000275493.6:c.2579A>T 7:g.55191828A>T EGFR ENST00000275493.6 3633 3236 1109718 1109718 1023628 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51780877 COSM26717 99375410 c.2579A>T p.K860I Substitution - Missense het 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 18372921 surgery-fixed primary 88 ENSP00000275493.2:p.Lys860Ile ENST00000275493.6:c.2579A>T 7:g.55191828A>T EGFR ENST00000275493.6 3633 3236 R056-R1 2813482 2669874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289246 COSM8268187 99378347 c.788C>T p.T263I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 42 ENSP00000275493.2:p.Thr263Ile ENST00000275493.6:c.788C>T 7:g.55154051C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460095 1460095 1383972 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471562 1471562 1395301 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206716 1206716 1118594 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003551-T01-IM5 2720036 2578857 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008442-T01-IM5 2724559 2583380 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009042-T01-IM5 2725031 2583852 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 132551512 c.2113G>C p.A705P Substitution - Missense het 38 7:55174785-55174785 + - PATHOGENIC .99356 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala705Pro ENST00000454757.6:c.2113G>C 7:g.55174785G>C EGFR ENST00000275493.6 3633 3236 P-0002780-T01-IM3 2719011 2577832 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0002768-T01-IM3 2719000 2577821 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 003 2640407 2500709 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 27545006 NS NS 66 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1001246 1001246 918469 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 123 2748095 2606798 stomach NS NS NS carcinoma NS NS NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 683 NS primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM7-I2 2813444 2669836 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 P-0006119-T01-IM5 2722498 2581319 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51836484 COSM6948259 99445210 c.857G>A p.S286N Substitution - Missense het 38 7:55154120-55154120 + - PATHOGENIC .95351 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Ser286Asn ENST00000275493.6:c.857G>A 7:g.55154120G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876654 2876654 2731169 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 circulating tumour NS 63 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876630 2876630 2731145 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51795112 COSM23633 132573436 c.2141T>A p.I714N Substitution - Missense 38 7:55174813-55174813 + - PATHOGENIC .99182 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000395243.3:p.Ile714Asn ENST00000454757.6:c.2141T>A 7:g.55174813T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD7044a 1504255 1427133 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51826432 COSM4384121 132581066 c.1435G>A p.V479I Substitution - Missense 38 7:55161570-55161570 + - PATHOGENIC .78109 Confirmed somatic variant 24030381 NS NS ENSP00000395243.3:p.Val479Ile ENST00000454757.6:c.1435G>A 7:g.55161570G>A EGFR ENST00000275493.6 3633 3236 1713239 1713239 1620973 pleura NS NS NS mesothelioma epithelial NS NS n COSV51779794 COSM53264 99387824 c.2174C>T p.T725M Substitution - Missense het 38 7:55174033-55174033 + - PATHOGENIC .97744 Confirmed somatic variant 22412050 surgery-fixed NS 59 ENSP00000275493.2:p.Thr725Met ENST00000275493.6:c.2174C>T 7:g.55174033C>T EGFR ENST00000275493.6 3633 3236 2749088 2749088 2607791 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51779794 COSM53264 99387824 c.2174C>T p.T725M Substitution - Missense 38 7:55174033-55174033 + - PATHOGENIC .97744 Confirmed somatic variant 29360550 surgery-fixed NS 67 ENSP00000275493.2:p.Thr725Met ENST00000275493.6:c.2174C>T 7:g.55174033C>T EGFR ENST00000275493.6 3633 3236 TCGA-RD-A7BT-01 2263044 2130028 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99295752 COSM8178996 99402706 c.715G>A p.G239S Substitution - Missense 38 7:55152632-55152632 + - PATHOGENIC .99504 Confirmed somatic variant 541 NS primary 66 ENSP00000275493.2:p.Gly239Ser ENST00000275493.6:c.715G>A 7:g.55152632G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002085-T02-IM5 2719477 2578298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767827 COSM1235378 132569177 c.2425A>T p.T809S Substitution - Missense het 38 7:55191809-55191809 + - PATHOGENIC .98595 Confirmed somatic variant 28481359 NS metastasis ENSP00000395243.3:p.Thr809Ser ENST00000454757.6:c.2425A>T 7:g.55191809A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010180-T01-IM5 2725979 2584800 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006960-T01-IM5 2723335 2582156 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51787507 COSM13188 133213942 c.2146G>A p.D716N Substitution - Missense het 38 7:55174818-55174818 + - PATHOGENIC .99476 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Asp716Asn ENST00000455089.5:c.2146G>A 7:g.55174818G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SC_9028 2467372 2330203 prostate NS NS NS carcinoma NS NS NS y COSV51850909 COSM5557485 132562424 c.2203A>G p.I735V Substitution - Missense het 38 7:55181347-55181347 + - PATHOGENIC .9793 Confirmed somatic variant 26000489 surgery - NOS metastasis 71 ENSP00000395243.3:p.Ile735Val ENST00000454757.6:c.2203A>G 7:g.55181347A>G EGFR ENST00000275493.6 3633 3236 P-0001042-T01-IM3 2716511 2575332 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1790527 1790527 1693506 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51815927 COSM24971 133219942 c.2378T>C p.L793P Substitution - Missense 38 7:55191762-55191762 + - PATHOGENIC .97813 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000415559.1:p.Leu793Pro ENST00000455089.5:c.2378T>C 7:g.55191762T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001442-T01-IM3 2717305 2576126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 132565801 c.2146G>T p.D716Y Substitution - Missense het 38 7:55174818-55174818 + - PATHOGENIC .99554 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000395243.3:p.Asp716Tyr ENST00000454757.6:c.2146G>T 7:g.55174818G>T EGFR ENST00000275493.6 3633 3236 TCGA-IR-A3LA-01 2193391 2061669 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51796224 COSM4844514 99420826 c.1648G>C p.V550L Substitution - Missense 38 7:55163749-55163749 + - PATHOGENIC .98124 Confirmed somatic variant 415 NS NS 60 ENSP00000275493.2:p.Val550Leu ENST00000275493.6:c.1648G>C 7:g.55163749G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471559 1471559 1395298 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1505378 1505378 1428252 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A014-T-S25 2758134 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009957-T01-IM5 2725784 2584605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 16913 1423755 1333783 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-71-8520-01 2194759 2063037 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001248 1001248 918471 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008145-T01-IM5 2724309 2583130 breast NS NS NS carcinoma NS NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 P-0012056-T01-IM5 2727199 2586020 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51827170 COSM6982292 99452487 c.3553G>A p.G1185S Substitution - Missense het 38 7:55205537-55205537 + - PATHOGENIC .9751 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly1185Ser ENST00000275493.6:c.3553G>A 7:g.55205537G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008262-T01-IM5 2724401 2583222 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-14-2554-01 1338017 1248402 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 52 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152698 2152698 2021708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-MV-A51V-01 2193279 2061557 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51815409 COSM7143473 132562190 c.1034A>G p.Q345R Substitution - Missense 38 7:55156794-55156794 + - NEUTRAL .3199 Confirmed somatic variant 413 NS NS 75 ENSP00000395243.3:p.Gln345Arg ENST00000454757.6:c.1034A>G 7:g.55156794A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811972 2811972 2668500 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 31534501 surgery-fixed metastasis 64 ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003316-T01-IM5 2719809 2578630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense het 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 2772383 2772383 2630573 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV99290341 COSM7347800 99432066 c.1016G>A p.G339E Substitution - Missense 38 7:55156542-55156542 + - PATHOGENIC .99668 Confirmed somatic variant 29807833 circulating tumour NS ENSP00000275493.2:p.Gly339Glu ENST00000275493.6:c.1016G>A 7:g.55156542G>A EGFR ENST00000275493.6 3633 3236 TCGA-FR-A8YC-06 2263445 2130429 skin NS NS NS malignant_melanoma NS NS NS y COSV51772860 COSM5872872 99415407 c.683C>T p.P228L Substitution - Missense 38 7:55152600-55152600 + - PATHOGENIC .99115 Confirmed somatic variant 540 NS NS 78 ENSP00000275493.2:p.Pro228Leu ENST00000275493.6:c.683C>T 7:g.55152600C>T EGFR ENST00000275493.6 3633 3236 1312381 1312381 1223290 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense het + - Confirmed somatic variant 19723643 surgery fresh/frozen NS 76 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2115534 2115534 1989778 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002768-T01-IM3 2719000 2577821 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 003 2640407 2500709 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 27545006 NS NS 66 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002780-T01-IM3 2719011 2577832 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1139401 1139401 1051965 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 18317075 surgery - NOS primary 75 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010864-T01-IM5 2726533 2585354 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51864573 COSM6977465 132556431 c.982C>T p.P328S Substitution - Missense het 38 7:55156643-55156643 + - PATHOGENIC .91736 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Pro328Ser ENST00000454757.6:c.982C>T 7:g.55156643C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-D1-A2G5-01 2198276 2066554 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99295137 COSM8817249 133243321 c.1738A>G p.T580A Substitution - Missense 38 7:55165430-55165430 + - PATHOGENIC .99619 Confirmed somatic variant 419 NS NS 50 ENSP00000415559.1:p.Thr580Ala ENST00000455089.5:c.1738A>G 7:g.55165430A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002085-T02-IM5 2719477 2578298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 NS metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A062-T-S31 2757401 2615999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211044 1211044 1122912 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001300-T01-IM3 2717020 2575841 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009661-T01-IM5 2725553 2584374 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004691-T01-IM5 2721092 2579913 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KD591 1004977 922189 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary 50 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007779-T01-IM5 2724014 2582835 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004812 1004812 922024 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16140420 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471560 1471560 1395299 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0010345-T02-IM5 2726112 2584933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790040 COSM6978158 99394234 c.2499_2500delinsTT p.L833_V834delinsFL Substitution - Missense het 38 7:55191748-55191749 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu833_Val834delinsPheLeu ENST00000275493.6:c.2499_2500delinsTT 7:g.55191748_55191749delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152698 2152698 2021708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577028 COSM9413137 99460459 c.1472T>A p.I491K Substitution - Missense 38 7:55160312-55160312 + - NEUTRAL .08768 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000275493.2:p.Ile491Lys ENST00000275493.6:c.1472T>A 7:g.55160312T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836288 COSM6348843 132575756 c.2207G>T p.C736F Substitution - Missense 38 7:55181351-55181351 + - PATHOGENIC .98402 Confirmed somatic variant 660 NS primary 46 ENSP00000395243.3:p.Cys736Phe ENST00000454757.6:c.2207G>T 7:g.55181351G>T EGFR ENST00000275493.6 3633 3236 P-0003393-T01-IM5 2719877 2578698 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51792310 COSM6928197 99381439 c.50C>T p.A17V Substitution - Missense het 38 7:55019327-55019327 + - NEUTRAL .01177 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ala17Val ENST00000275493.6:c.50C>T 7:g.55019327C>T EGFR ENST00000275493.6 3633 3236 1074387 1074387 989641 bone fibula NS NS osteosarcoma NS NS NS n COSV51796850 COSM24846 99415765 c.2491C>T p.R831C Substitution - Missense het 38 7:55191740-55191740 + - PATHOGENIC .9406 Confirmed somatic variant 17509661 fixed - NOS NS 44 ENSP00000275493.2:p.Arg831Cys ENST00000275493.6:c.2491C>T 7:g.55191740C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 702 898393 816005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001246 1001246 918469 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982775 982775 898494 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004607-T03-IM5 2721003 2579824 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460147 1460147 1384024 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005845-T01-IM5 2722230 2581051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2906646 2906646 2760897 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29616327 surgery-fixed metastasis 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005010 1005010 922222 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001245 1001245 918468 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005001 1005001 922213 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004998 1004998 922210 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489259 1489259 1412417 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SC-her2-025 2313847 2179043 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51850822 COSM4771564 133219201 c.2461G>C p.E821Q Substitution - Missense 38 7:55191845-55191845 + - PATHOGENIC .99128 Confirmed somatic variant 24185512 surgery fresh/frozen metastasis ENSP00000415559.1:p.Glu821Gln ENST00000455089.5:c.2461G>C 7:g.55191845G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-A6S1-01 2263260 2130244 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS primary 53 ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811925 2811925 2668484 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51823614 COSM4170219 133202511 c.2120C>T p.S707F Substitution - Missense 38 7:55174792-55174792 + - PATHOGENIC .98332 Confirmed somatic variant 31534501 pleural effusion NS 61 ENSP00000415559.1:p.Ser707Phe ENST00000455089.5:c.2120C>T 7:g.55174792C>T EGFR ENST00000275493.6 3633 3236 5-VS092-T1 2869925 2724922 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110023 COSM9807078 99382431 c.3406C>T p.P1136S Substitution - Missense 38 7:55205390-55205390 + - PATHOGENIC .97468 Confirmed somatic variant 26950094 surgery - NOS NS 77 ENSP00000275493.2:p.Pro1136Ser ENST00000275493.6:c.3406C>T 7:g.55205390C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2696517 2696517 2555421 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28201779 surgery fresh/frozen NS 60 ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 P-0006960-T01-IM5 2723335 2582156 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51767379 COSM85894 99384993 c.2527G>A p.V843I Substitution - Missense het 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Val843Ile ENST00000275493.6:c.2527G>A 7:g.55191776G>A EGFR ENST00000275493.6 3633 3236 P-0002614-T01-IM3 2718868 2577689 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1438353 1438353 1346127 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS n COSV51766618 COSM12374 133206840 c.2447T>G p.L816R Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 20823418 surgery fresh/frozen primary 76 ENSP00000415559.1:p.Leu816Arg ENST00000455089.5:c.2447T>G 7:g.55191831T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD24225a 2234144 2101649 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV51817351 COSM3881830 133223235 c.2957G>A p.R986Q Substitution - Missense 38 7:55201333-55201333 + - PATHOGENIC .98371 Confirmed somatic variant 652 NS NS ENSP00000415559.1:p.Arg986Gln ENST00000455089.5:c.2957G>A 7:g.55201333G>A EGFR ENST00000275493.6 3633 3236 P-0010967-T01-IM5 2726608 2585429 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51856949 COSM6978220 99453333 c.413G>T p.R138I Substitution - Missense het 38 7:55143477-55143477 + - PATHOGENIC .94211 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg138Ile ENST00000275493.6:c.413G>T 7:g.55143477G>T EGFR ENST00000275493.6 3633 3236 2390066 2390066 2252898 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM5033534 178387739 c.? p.R675Q Substitution - Missense + - Confirmed somatic variant 25740784 surgery - NOS NS 42 ENSP00000275493.2:p.Arg675Gln EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914581 914581 832030 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense het 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 15788655 surgery fresh/frozen primary 72 ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0012043-T01-IM5 2727190 2586011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-GN-A269-01 2121799 1996035 skin NS NS NS malignant_melanoma NS NS NS y COSV51823432 COSM3639727 132561830 c.566A>G p.N189S Substitution - Missense 38 7:55152618-55152618 + - PATHOGENIC .95999 Confirmed somatic variant 540 NS NS 70 ENSP00000395243.3:p.Asn189Ser ENST00000454757.6:c.566A>G 7:g.55152618A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-CD-A4MG-01 2198123 2066401 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51852047 COSM3881818 132564599 c.1154C>T p.T385I Substitution - Missense 38 7:55157744-55157744 + - PATHOGENIC .99429 Confirmed somatic variant 541 NS NS 76 ENSP00000395243.3:p.Thr385Ile ENST00000454757.6:c.1154C>T 7:g.55157744C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003016-T01-IM3 2719225 2578046 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51839629 COSM6925694 132578916 c.389C>T p.T130I Substitution - Missense het 38 7:55143453-55143453 + - NEUTRAL .47678 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr130Ile ENST00000454757.6:c.389C>T 7:g.55143453C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458684 1458684 1382659 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876045 2876045 2730560 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 52 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A065-T-S26 2757405 2616000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914586 914586 832035 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001442-T01-IM3 2717305 2576126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 R056-R1 2813482 2669874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289246 COSM8268187 133206444 c.653C>T p.T218I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 42 ENSP00000415559.1:p.Thr218Ile ENST00000455089.5:c.653C>T 7:g.55154051C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003417-T01-IM5 2719901 2578722 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS n COSV51815967 COSM39522 133205184 c.520T>G p.C174G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Cys174Gly ENST00000455089.5:c.520T>G 7:g.55152572T>G EGFR ENST00000275493.6 3633 3236 1001245 1001245 918468 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 982775 982775 898494 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372112 2372112 2234905 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_III anaplastic NS n COSV51822289 COSM42977 132570284 c.315G>T p.Q105H Substitution - Missense 38 7:55143379-55143379 + - PATHOGENIC .90579 Confirmed somatic variant 25694352 surgery fresh/frozen NS 28 ENSP00000395243.3:p.Gln105His ENST00000454757.6:c.315G>T 7:g.55143379G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-E1-A7YD-01 2386254 2249086 central_nervous_system brain NS NS glioma NS NS NS y COSV51785554 COSM21688 132548847 c.836G>T p.R279L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 545 NS primary 57 ENSP00000395243.3:p.Arg279Leu ENST00000454757.6:c.836G>T 7:g.55155911G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MTP6_T1 2875766 2730344 pancreas NS NS NS other dysplasia-in_situ_neoplasm NS NS y COSV51779524 COSM18425 132552477 c.2021G>A p.G674D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Confirmed somatic variant 32796935 surgery-fixed NS 65 ENSP00000395243.3:p.Gly674Asp ENST00000454757.6:c.2021G>A 7:g.55174015G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A065-T-S18 2757403 2616000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1451165 1451165 1375308 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 132560202 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005889-T01-IM5 2722273 2581094 testis NS NS NS germ_cell_tumour seminoma NS NS n COSV51857848 COSM6946731 132552853 c.1319G>A p.G440D Substitution - Missense het 38 7:55160294-55160294 + - NEUTRAL .16911 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Gly440Asp ENST00000454757.6:c.1319G>A 7:g.55160294G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2757166 2757166 2615808 haematopoietic_and_lymphoid_tissue skin NS NS lymphoid_neoplasm mycosis_fungoides-Sezary_syndrome NS NS y COSV104576496 COSM9308820 133254438 c.1111G>A p.D371N Substitution - Missense 38 7:55157701-55157701 + - PATHOGENIC .96223 Confirmed somatic variant 26551670 blood-bone marrow secondary ENSP00000415559.1:p.Asp371Asn ENST00000455089.5:c.1111G>A 7:g.55157701G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM7-I1 2813443 2669835 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 P-0007994-T01-IM5 2724178 2582999 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51811471 COSM6960839 99418358 c.380C>A p.A127E Substitution - Missense het 38 7:55143444-55143444 + - NEUTRAL .44126 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ala127Glu ENST00000275493.6:c.380C>A 7:g.55143444C>A EGFR ENST00000275493.6 3633 3236 P-0005701-T01-IM5 2722086 2580907 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD42110c 2894819 2749307 skin extremity NS NS malignant_melanoma nodular NS NS y COSV105111084 COSM9905470 133238907 c.1885G>A p.V629I Substitution - Missense 38 7:55173083-55173083 + - PATHOGENIC .9014 Confirmed somatic variant 33024263 surgery-fixed metastasis ENSP00000415559.1:p.Val629Ile ENST00000455089.5:c.1885G>A 7:g.55173083G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 23 2699404 2558308 skin NS NS NS malignant_melanoma NS NS NS n COSV51774288 COSM6906389 132560534 c.1121_1122delinsTT p.A374V Substitution - Missense het 38 7:55157711-55157712 + - Confirmed somatic variant 29420467 surgery-fixed NS ENSP00000395243.3:p.Ala374Val ENST00000454757.6:c.1121_1122delinsTT 7:g.55157711_55157712delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 60 2699441 2558345 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51859123 COSM6906662 133233177 c.1903C>T p.R635W Substitution - Missense het 38 7:55173101-55173101 + - PATHOGENIC .98228 Confirmed somatic variant 29420467 surgery-fixed NS ENSP00000415559.1:p.Arg635Trp ENST00000455089.5:c.1903C>T 7:g.55173101C>T EGFR ENST00000275493.6 3633 3236 1894611 1894611 1783303 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51837887 COSM1238071 99459039 c.2113A>G p.R705G Substitution - Missense hom 38 7:55173972-55173972 + - PATHOGENIC .89723 Confirmed somatic variant 23578570 surgery-fixed NS 33 ENSP00000275493.2:p.Arg705Gly ENST00000275493.6:c.2113A>G 7:g.55173972A>G EGFR ENST00000275493.6 3633 3236 2152698 2152698 2021708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S0377 897601 815224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 15118125 surgery - NOS primary ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S001018 1027698 944674 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1472947 1472947 1396646 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51816076 COSM53287 132568521 c.1996G>A p.E666K Substitution - Missense 38 7:55173990-55173990 + - PATHOGENIC .97511 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000395243.3:p.Glu666Lys ENST00000454757.6:c.1996G>A 7:g.55173990G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-2563 2108004 1985865 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 99380629 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Arg252Cys ENST00000275493.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1472951 1472951 1396650 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51853438 COSM53289 132586238 c.2263G>A p.D755N Substitution - Missense 38 7:55181407-55181407 + - PATHOGENIC .96481 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000395243.3:p.Asp755Asn ENST00000454757.6:c.2263G>A 7:g.55181407G>A EGFR ENST00000275493.6 3633 3236 1505362 1505362 1428240 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51797142 COSM87246 99450056 c.2561C>T p.T854I Substitution - Missense 38 7:55191810-55191810 + - PATHOGENIC .97885 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000275493.2:p.Thr854Ile ENST00000275493.6:c.2561C>T 7:g.55191810C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DK-A3WW-01 2193226 2061504 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51790783 COSM3778506 132569877 c.3100G>A p.E1034K Substitution - Missense 38 7:55202589-55202589 + - PATHOGENIC .973 Confirmed somatic variant 413 NS NS 57 ENSP00000395243.3:p.Glu1034Lys ENST00000454757.6:c.3100G>A 7:g.55202589G>A EGFR ENST00000275493.6 3633 3236 Pat_28_B 2513795 2376164 NS NS NS NS malignant_melanoma NS NS NS y COSV51792098 COSM5872886 99381328 c.3359G>A p.S1120N Substitution - Missense 38 7:55205343-55205343 + - NEUTRAL .13132 Confirmed somatic variant 24265153 surgery-fixed NS 58 ENSP00000275493.2:p.Ser1120Asn ENST00000275493.6:c.3359G>A 7:g.55205343G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1894611 1894611 1783303 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51837871 COSM1238072 133283348 c.1501C>T p.P501S Substitution - Missense hom 38 7:55163737-55163737 + - PATHOGENIC .99252 Confirmed somatic variant 23578570 surgery-fixed NS 33 ENSP00000415559.1:p.Pro501Ser ENST00000455089.5:c.1501C>T 7:g.55163737C>T EGFR ENST00000275493.6 3633 3236 1052765 1052765 968836 soft_tissue fibrous_tissue_and_uncertain_origin NS NS fibrosarcoma myxofibrosarcoma NS NS n COSM24271 178382727 c.? p.E734K Substitution - Missense + - Confirmed somatic variant 17376509 surgery - NOS NS ENSP00000275493.2:p.Glu734Lys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T3265 2658621 2518780 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51815655 COSM6652276 132621472 c.778G>A p.G260S Substitution - Missense 38 7:55155853-55155853 + - PATHOGENIC .97718 Confirmed somatic variant 27149842 NS NS 74.91 ENSP00000395243.3:p.Gly260Ser ENST00000454757.6:c.778G>A 7:g.55155853G>A EGFR ENST00000275493.6 3633 3236 2625883 2625883 2486295 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51796371 COSM6191453 99438939 c.203C>T p.T68I Substitution - Missense 38 7:55142400-55142400 + - PATHOGENIC .99116 Confirmed somatic variant 25617745 surgery-fixed NS 61 ENSP00000275493.2:p.Thr68Ile ENST00000275493.6:c.203C>T 7:g.55142400C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577026 COSM9413136 99460444 c.1393G>C p.G465R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .4176 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000275493.2:p.Gly465Arg ENST00000275493.6:c.1393G>C 7:g.55160233G>C EGFR ENST00000275493.6 3633 3236 245 898397 816009 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EXTERN_MELA_20140924_049 2839381 2695147 skin neck NS NS malignant_melanoma NS NS NS y COSV104576959 COSM9291837 132588413 c.3316T>A p.F1106I Substitution - Missense 38 7:55205435-55205435 + - NEUTRAL .31568 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000395243.3:p.Phe1106Ile ENST00000454757.6:c.3316T>A 7:g.55205435T>A EGFR ENST00000275493.6 3633 3236 CHC1774T 2340683 2205666 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51807517 COSM4802395 99429114 c.67C>T p.R23W Substitution - Missense 38 7:55019344-55019344 + - NEUTRAL .00803 Confirmed somatic variant 381 NS primary 65 ENSP00000275493.2:p.Arg23Trp ENST00000275493.6:c.67C>T 7:g.55019344C>T EGFR ENST00000275493.6 3633 3236 PD8733a 1588462 1509633 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia_with_ringed_sideroblasts NS n COSV51795335 COSM53232 99416647 c.2122A>G p.K708E Substitution - Missense 38 7:55173981-55173981 + - PATHOGENIC .98155 Confirmed somatic variant 24030381 NS NS ENSP00000275493.2:p.Lys708Glu ENST00000275493.6:c.2122A>G 7:g.55173981A>G EGFR ENST00000275493.6 3633 3236 TCGA-12-0670 2108025 1985886 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 99378725 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Thr263Pro ENST00000275493.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 KD534 1004976 922188 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811937 2811937 2668488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion metastasis 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489241 1489241 1412399 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458680 1458680 1382655 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009451-T01-IM5 2725378 2584199 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51781835 COSM174732 132552286 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Glu114Lys ENST00000454757.6:c.340G>A 7:g.55143404G>A EGFR ENST00000275493.6 3633 3236 1505362 1505362 1428240 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51779291 COSM26446 99389123 c.2524A>G p.N842D Substitution - Missense 38 7:55191773-55191773 + - PATHOGENIC .986 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000275493.2:p.Asn842Asp ENST00000275493.6:c.2524A>G 7:g.55191773A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003456-T01-IM5 2719933 2578754 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 132553689 c.619C>T p.R207C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg207Cys ENST00000454757.6:c.619C>T 7:g.55154017C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152756 2152756 2021766 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51845233 COSM3734669 133208259 c.2083A>G p.I695V Substitution - Missense 38 7:55174755-55174755 + - PATHOGENIC .99591 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Ile695Val ENST00000455089.5:c.2083A>G 7:g.55174755A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2372112 2372112 2234905 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_III anaplastic NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 25694352 surgery fresh/frozen NS 28 ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000918-T01-IM3 2716255 2575076 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577025 COSM9413133 133285165 c.1191C>G p.S397R Substitution - Missense 38 7:55160166-55160166 + - NEUTRAL .15107 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000415559.1:p.Ser397Arg ENST00000455089.5:c.1191C>G 7:g.55160166C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1074387 1074387 989641 bone fibula NS NS osteosarcoma NS NS NS n COSV51796850 COSM24846 132580433 c.2356C>T p.R786C Substitution - Missense het 38 7:55191740-55191740 + - PATHOGENIC .9406 Confirmed somatic variant 17509661 fixed - NOS NS 44 ENSP00000395243.3:p.Arg786Cys ENST00000454757.6:c.2356C>T 7:g.55191740C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EXTERN_MELA_20140514_008 2839310 2695076 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV104577177 COSM9365746 132615373 c.1861C>T p.L621F Substitution - Missense 38 7:55173059-55173059 + - PATHOGENIC .98429 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000395243.3:p.Leu621Phe ENST00000454757.6:c.1861C>T 7:g.55173059C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM12 2144553 2013767 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 24285547 surgery fresh/frozen primary 64 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920037 920037 837116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777782 COSM6227 132554599 c.2369A>T p.H790L Substitution - Missense het 38 7:55191753-55191753 + - PATHOGENIC .98607 Confirmed somatic variant 15623594 surgery fresh/frozen NS 76 ENSP00000395243.3:p.His790Leu ENST00000454757.6:c.2369A>T 7:g.55191753A>T EGFR ENST00000275493.6 3633 3236 TCGA-OL-A97C-01 2386126 2248958 breast NS NS NS carcinoma NS NS NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 414 NS primary 67 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 SF268 1998472 1883544 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 23856246 cell-line primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 T3174 2658322 2518481 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 99383629 c.1580G>A p.R527Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 74.41 ENSP00000275493.2:p.Arg527Gln ENST00000275493.6:c.1580G>A 7:g.55161580G>A EGFR ENST00000275493.6 3633 3236 P-0008346-T01-IM5 2830127 2685942 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51838649 COSM6962468 99418377 c.412A>G p.R138G Substitution - Missense 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 30205045 surgery-fixed primary 61 ENSP00000275493.2:p.Arg138Gly ENST00000275493.6:c.412A>G 7:g.55143476A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006541-T01-IM5 2722916 2581737 NS NS NS NS malignant_melanoma NS NS NS n COSV51823220 COSM13179 133214404 c.1945C>T p.P649S Substitution - Missense het 38 7:55173939-55173939 + - PATHOGENIC .97389 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Pro649Ser ENST00000455089.5:c.1945C>T 7:g.55173939C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 132551380 c.775C>T p.H259Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000395243.3:p.His259Tyr ENST00000454757.6:c.775C>T 7:g.55155850C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876602 2876602 2731117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 133216269 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 57 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM12 2144553 2013767 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 24285547 surgery fresh/frozen primary 64 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1790528 1790528 1693507 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767379 COSM85894 132557468 c.2392G>A p.V798I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000395243.3:p.Val798Ile ENST00000454757.6:c.2392G>A 7:g.55191776G>A EGFR ENST00000275493.6 3633 3236 2757166 2757166 2615808 haematopoietic_and_lymphoid_tissue skin NS NS lymphoid_neoplasm mycosis_fungoides-Sezary_syndrome NS NS y COSV104576496 COSM9308820 99430966 c.1246G>A p.D416N Substitution - Missense 38 7:55157701-55157701 + - PATHOGENIC .96223 Confirmed somatic variant 26551670 blood-bone marrow secondary ENSP00000275493.2:p.Asp416Asn ENST00000275493.6:c.1246G>A 7:g.55157701G>A EGFR ENST00000275493.6 3633 3236 2901989 2901989 2756229 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Leu861Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 ATL020 2488648 2351297 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm adult_T_cell_lymphoma-leukaemia NS NS y COSV51770269 COSM5710629 133238945 c.880G>A p.G294R Substitution - Missense 38 7:55156541-55156541 + - PATHOGENIC .9949 Confirmed somatic variant 26437031 NS NS 63 ENSP00000415559.1:p.Gly294Arg ENST00000455089.5:c.880G>A 7:g.55156541G>A EGFR ENST00000275493.6 3633 3236 5-VS026-T1 2869846 2724843 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV51846033 COSM5530399 99400841 c.2756C>T p.P919L Substitution - Missense 38 7:55198771-55198771 + - PATHOGENIC .97363 Confirmed somatic variant 26950094 surgery fresh/frozen NS 58 ENSP00000275493.2:p.Pro919Leu ENST00000275493.6:c.2756C>T 7:g.55198771C>T EGFR ENST00000275493.6 3633 3236 TCGA-EE-A20C-06 2121628 1995864 skin NS NS NS malignant_melanoma NS NS NS y COSV51765811 COSM3639748 99379625 c.2209A>G p.K737E Substitution - Missense 38 7:55174746-55174746 + - PATHOGENIC .92243 Confirmed somatic variant 540 NS NS 59 ENSP00000275493.2:p.Lys737Glu ENST00000275493.6:c.2209A>G 7:g.55174746A>G EGFR ENST00000275493.6 3633 3236 TCGA-06-A6S1-01 2263260 2130244 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS primary 53 ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001707-T01-IM3 2717834 2576655 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004979 1004979 922191 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_C35 1863716 1754607 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1790518 1790518 1693497 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811960 2811960 2668496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed NS 78 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489246 1489246 1412404 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1044284 1044284 960625 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460135 1460135 1384012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004991 1004991 922203 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458682 1458682 1382657 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A014-T-S39 2758137 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152798 2152798 2021808 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982863 982863 898582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A014-T-S44 2758138 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876058 2876058 2730573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 56 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-EE-A3AB-06 2121693 1995929 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 99380065 c.1168C>A p.Q390K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 540 NS NS 30 ENSP00000275493.2:p.Gln390Lys ENST00000275493.6:c.1168C>A 7:g.55156793C>A EGFR ENST00000275493.6 3633 3236 MELA_20076 2760731 2619264 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 99380065 c.1168C>A p.Q390K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 30178487 surgery fresh/frozen metastasis 30 ENSP00000275493.2:p.Gln390Lys ENST00000275493.6:c.1168C>A 7:g.55156793C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003705-T01-IM5 2720193 2579014 large_intestine appendix NS NS carcinoma adenocarcinoma NS NS n COSV51812036 COSM48318 133265354 c.1654G>A p.A552T Substitution - Missense het 38 7:55165346-55165346 + - NEUTRAL .27484 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ala552Thr ENST00000455089.5:c.1654G>A 7:g.55165346G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836185 COSM4884832 132575704 c.604G>T p.D202Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 660 NS primary 46 ENSP00000395243.3:p.Asp202Tyr ENST00000454757.6:c.604G>T 7:g.55152656G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-WS012-T3 2869949 2724946 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110652 COSM9809446 133280813 c.2620C>T p.P874S Substitution - Missense 38 7:55198770-55198770 + - PATHOGENIC .97205 Confirmed somatic variant 26950094 surgery - NOS NS 82 ENSP00000415559.1:p.Pro874Ser ENST00000455089.5:c.2620C>T 7:g.55198770C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 R074-R1 2813496 2669888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 41 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2152761 2152761 2021771 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489254 1489254 1412412 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1460154 1460154 1384031 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0010836-T01-IM5 2726504 2585325 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152768 2152768 2021778 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 42 897188 814811 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876654 2876654 2731169 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 63 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920018 920018 837097 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 PD6112a 1480266 1403925 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51812104 COSM4384126 99416572 c.2548C>G p.H850D Substitution - Missense 38 7:55191797-55191797 + - PATHOGENIC .98487 Confirmed somatic variant 24030381 NS NS ENSP00000275493.2:p.His850Asp ENST00000275493.6:c.2548C>G 7:g.55191797C>G EGFR ENST00000275493.6 3633 3236 GBM12 2144553 2013767 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 24285547 surgery fresh/frozen primary 64 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 171T 2473937 2336707 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 26489445 fixed - NOS NS ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006290-T01-IM5 2722667 2581488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51839751 COSM6949885 133220850 c.1791G>T p.K597N Substitution - Missense het 38 7:55172989-55172989 + - PATHOGENIC .95891 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Lys597Asn ENST00000455089.5:c.1791G>T 7:g.55172989G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005016 1005016 922228 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-A6S1-01 2263260 2130244 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 329 NS primary 53 ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1472947 1472947 1396646 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51816063 COSM53286 132584886 c.1963A>T p.N655Y Substitution - Missense 38 7:55173957-55173957 + - PATHOGENIC .98177 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000395243.3:p.Asn655Tyr ENST00000454757.6:c.1963A>T 7:g.55173957A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004870 1007062 924270 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 16863509 NS NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010345-T01-IM5 2726113 2584934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-EE-A17X-06 2121618 1995854 skin NS NS NS malignant_melanoma NS NS NS y COSV51781835 COSM174732 133207258 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 540 NS NS 54 ENSP00000415559.1:p.Glu114Lys ENST00000455089.5:c.340G>A 7:g.55143404G>A EGFR ENST00000275493.6 3633 3236 2675054 2675054 2534329 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM1169669 178386037 c.? p.T263P Substitution - Missense + - Confirmed somatic variant 29110836 surgery-fixed NS 53 ENSP00000275493.2:p.Thr263Pro EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51808387 COSM3412196 132564457 c.1658G>C p.G553A Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000395243.3:p.Gly553Ala ENST00000454757.6:c.1658G>C 7:g.55165350G>C EGFR ENST00000275493.6 3633 3236 PC-9ER 2015225 1897433 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 23733853 cell-line NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876052 2876052 2730567 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 78 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-2563 2108004 1985865 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 133208833 c.619C>T p.R207C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Arg207Cys ENST00000455089.5:c.619C>T 7:g.55154017C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 19T 2745856 2604559 liver NS NS NS other neoplasm NS NS y COSV51840438 COSM1727959 133222062 c.374A>G p.Y125C Substitution - Missense 38 7:55143438-55143438 + - PATHOGENIC .99088 Confirmed somatic variant 660 NS primary 71 ENSP00000415559.1:p.Tyr125Cys ENST00000455089.5:c.374A>G 7:g.55143438A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 ESCC_61 2479566 2342326 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51828987 COSM5632947 132552333 c.2006A>C p.K669T Substitution - Missense 38 7:55174000-55174000 + - PATHOGENIC .9691 Confirmed somatic variant 26873401 NS NS 53 ENSP00000395243.3:p.Lys669Thr ENST00000454757.6:c.2006A>C 7:g.55174000A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 98019 1520664 1443039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51786915 COSM94179 133215685 c.475G>A p.E159K Substitution - Missense 38 7:55151344-55151344 + - NEUTRAL .0681 Confirmed somatic variant 20668451 NS primary ENSP00000415559.1:p.Glu159Lys ENST00000455089.5:c.475G>A 7:g.55151344G>A EGFR ENST00000275493.6 3633 3236 P-0005114-T01-IM5 2721517 2580338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51817830 COSM6941076 99406389 c.2600A>C p.K867T Substitution - Missense het 38 7:55191849-55191849 + - PATHOGENIC .9501 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Lys867Thr ENST00000275493.6:c.2600A>C 7:g.55191849A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009239-T01-IM5 2725198 2584019 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51792469 COSM6967655 132569219 c.1472T>A p.V491E Substitution - Missense het 38 7:55161607-55161607 + - PATHOGENIC .99007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Val491Glu ENST00000454757.6:c.1472T>A 7:g.55161607T>A EGFR ENST00000275493.6 3633 3236 ATL020 2488648 2351297 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm adult_T_cell_lymphoma-leukaemia NS NS y COSV51770269 COSM5710629 99412561 c.1015G>A p.G339R Substitution - Missense 38 7:55156541-55156541 + - PATHOGENIC .9949 Confirmed somatic variant 26437031 NS NS 63 ENSP00000275493.2:p.Gly339Arg ENST00000275493.6:c.1015G>A 7:g.55156541G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876591 2876591 2731106 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 133216269 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 74 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2254T>A 7:g.55181398T>A EGFR ENST00000275493.6 3633 3236 1471558 1471558 1395297 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A014-T-S47 2758139 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1487000 1487000 1410618 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51807094 COSM20893 99394489 c.2522G>A p.R841K Substitution - Missense 38 7:55191771-55191771 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 58 ENSP00000275493.2:p.Arg841Lys ENST00000275493.6:c.2522G>A 7:g.55191771G>A EGFR ENST00000275493.6 3633 3236 P-0008257-T01-IM5 2724396 2583217 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766389 COSM43067 99404429 c.874G>T p.V292L Substitution - Missense het 38 7:55154137-55154137 + - PATHOGENIC .98997 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Val292Leu ENST00000275493.6:c.874G>T 7:g.55154137G>T EGFR ENST00000275493.6 3633 3236 PD6780a 1503990 1426868 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia_with_ringed_sideroblasts NS n COSV51791654 COSM4384111 99417205 c.95A>G p.Q32R Substitution - Missense 38 7:55142292-55142292 + - PATHOGENIC .96882 Confirmed somatic variant 24030381 NS NS ENSP00000275493.2:p.Gln32Arg ENST00000275493.6:c.95A>G 7:g.55142292A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1589268 1589268 1510422 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51809033 COSM133147 132557426 c.1997_1998inv p.E666V Substitution - Missense 38 7:55173991-55173992 + - Confirmed somatic variant 22026926 surgery fresh/frozen NS ENSP00000395243.3:p.Glu666Val ENST00000454757.6:c.1997_1998inv 7:g.55173991_55173992inv EGFR ENST00000275493.6 3633 3236 P-0003417-T01-IM5 2719901 2578722 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS n COSV51815967 COSM39522 99377187 c.655T>G p.C219G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Cys219Gly ENST00000275493.6:c.655T>G 7:g.55152572T>G EGFR ENST00000275493.6 3633 3236 2901986 2901986 2756229 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 APGI-AMP-2890 2866039 2721116 pancreas ampulla_of_Vater NS NS carcinoma ductal_carcinoma NS NS y COSV105111099 COSM9620623 133249162 c.526G>A p.G176R Substitution - Missense 38 7:55152578-55152578 + - NEUTRAL .36671 Confirmed somatic variant 26804919 surgery fresh/frozen NS ENSP00000415559.1:p.Gly176Arg ENST00000455089.5:c.526G>A 7:g.55152578G>A EGFR ENST00000275493.6 3633 3236 TCGA-CJ-4868-01 2120501 1994737 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51791922 COSM3366979 99410018 c.2512C>A p.L838M Substitution - Missense 38 7:55191761-55191761 + - PATHOGENIC .88511 Confirmed somatic variant 416 NS NS 42 ENSP00000275493.2:p.Leu838Met ENST00000275493.6:c.2512C>A 7:g.55191761C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003175-T01-IM5 2719668 2578489 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51836358 COSM6926707 133284445 c.1923G>C p.R641S Substitution - Missense het 38 7:55173121-55173121 + - PATHOGENIC .86375 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Arg641Ser ENST00000455089.5:c.1923G>C 7:g.55173121G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1109718 1109718 1023628 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 88 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982881 982881 898600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001256 1001256 918479 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005114-T01-IM5 2721517 2580338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001247 1001247 918470 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920029 920029 837108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 40 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206767 1206767 1118645 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 896925 896925 814548 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1179552 1179552 1091514 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004981 1004981 922193 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T3174 2296192 2161795 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 132556268 c.1445G>A p.R482Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 25344691 NS NS 74.41 ENSP00000395243.3:p.Arg482Gln ENST00000454757.6:c.1445G>A 7:g.55161580G>A EGFR ENST00000275493.6 3633 3236 18195 2422953 2285875 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV51779680 COSM1313184 99406235 c.1151C>G p.T384S Substitution - Missense 38 7:55156776-55156776 + - PATHOGENIC .98418 Confirmed somatic variant 24469795 NS NS 61 ENSP00000275493.2:p.Thr384Ser ENST00000275493.6:c.1151C>G 7:g.55156776C>G EGFR ENST00000275493.6 3633 3236 P-0004695-T01-IM5 2721097 2579918 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1211136 1211136 1123004 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 53 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51776247 COSM6110417 133220044 c.1258G>A p.G420R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000415559.1:p.Gly420Arg ENST00000455089.5:c.1258G>A 7:g.55160233G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812083 2812083 2668551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 132551512 c.2113G>C p.A705P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Confirmed somatic variant 31534501 circulating tumour NS 68 ENSP00000395243.3:p.Ala705Pro ENST00000454757.6:c.2113G>C 7:g.55174785G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001971-T01-IM3 2718279 2577100 central_nervous_system brain NS NS glioma astrocytoma NS NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 2152698 2152698 2021708 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 920109 920109 837188 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51862985 COSM13431 99453632 c.2537A>G p.K846R Substitution - Missense het 38 7:55191786-55191786 + - PATHOGENIC .97673 Confirmed somatic variant 15623594 surgery-fixed NS 60 ENSP00000275493.2:p.Lys846Arg ENST00000275493.6:c.2537A>G 7:g.55191786A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010181-T01-IM5 2725980 2584801 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-DY-A1DF-01 1651675 1566462 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51776282 COSM1168015 99373518 c.2258C>T p.P753L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Confirmed somatic variant 375 NS primary 73 ENSP00000275493.2:p.Pro753Leu ENST00000275493.6:c.2258C>T 7:g.55174795C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009948-T02-IM5 2725775 2584596 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 P-0013704-T01-IM5 2803863 2660613 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51781835 COSM174732 99379122 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 29316426 surgery-fixed primary 71 ENSP00000275493.2:p.Glu114Lys ENST00000275493.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1790518 1790518 1693497 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51844033 COSM707173 133225427 c.2138A>G p.E713G Substitution - Missense 38 7:55174810-55174810 + - PATHOGENIC .9946 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000415559.1:p.Glu713Gly ENST00000455089.5:c.2138A>G 7:g.55174810A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PC-9ER 2015225 1897433 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 23733853 cell-line NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876052 2876052 2730567 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 78 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-D1-A2G5-01 2198276 2066554 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99295137 COSM8817249 99418051 c.1873A>G p.T625A Substitution - Missense 38 7:55165430-55165430 + - PATHOGENIC .99619 Confirmed somatic variant 419 NS NS 50 ENSP00000275493.2:p.Thr625Ala ENST00000275493.6:c.1873A>G 7:g.55165430A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-28-5209-01 2120334 1994570 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51808387 COSM3412196 133220832 c.1658G>C p.G553A Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 329 NS NS 66 ENSP00000415559.1:p.Gly553Ala ENST00000455089.5:c.1658G>C 7:g.55165350G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982791 982791 898510 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51779524 COSM18425 133207486 c.2021G>A p.G674D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Asp ENST00000455089.5:c.2021G>A 7:g.55174015G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-A2-A4S3-01 2187874 2056152 breast NS NS NS carcinoma NS NS NS y COSV51810209 COSM3833026 132552575 c.806A>G p.D269G Substitution - Missense 38 7:55155881-55155881 + - PATHOGENIC .96368 Confirmed somatic variant 414 NS NS 59 ENSP00000395243.3:p.Asp269Gly ENST00000454757.6:c.806A>G 7:g.55155881A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 pfg043T 2309624 2174826 stomach NS NS NS carcinoma intestinal_adenocarcinoma NS NS y COSV51790826 COSM4755611 133207124 c.431A>C p.K144T Substitution - Missense het 38 7:55151300-55151300 + - PATHOGENIC .93585 Confirmed somatic variant 24816253 surgery fresh/frozen NS 76 ENSP00000415559.1:p.Lys144Thr ENST00000455089.5:c.431A>C 7:g.55151300A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458685 1458685 1382660 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206714 1206714 1118592 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489250 1489250 1412408 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876666 2876666 2731181 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 pleural effusion NS 64 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004997 1004997 922209 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982854 982854 898573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876655 2876655 2731170 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 70 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458698 1458698 1382673 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 198 898387 815999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0006029-T01-IM5 2722410 2581231 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51862288 COSM6947601 99418938 c.2734T>G p.S912A Substitution - Missense het 38 7:55198749-55198749 + - PATHOGENIC .906 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Ser912Ala ENST00000275493.6:c.2734T>G 7:g.55198749T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 17234 1423805 1333833 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010267-T01-IM5 2726054 2584875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 IGC-04-1168 2662309 2522433 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 961851 961851 878135 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16467080 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152771 2152771 2021781 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489244 1489244 1412402 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1460151 1460151 1384028 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489242 1489242 1412400 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 65 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A017-T-S16 2757377 2615994 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 56 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1690841 1690841 1599108 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 132559938 c.1339A>C p.S447R Substitution - Missense het 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 22270724 surgery - NOS recurrent 64 ENSP00000395243.3:p.Ser447Arg ENST00000454757.6:c.1339A>C 7:g.55160314A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-B0-4849-01 2120441 1994677 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51791922 COSM3366979 132577144 c.2377C>A p.L793M Substitution - Missense 38 7:55191761-55191761 + - PATHOGENIC .88511 Confirmed somatic variant 416 NS NS 51 ENSP00000395243.3:p.Leu793Met ENST00000454757.6:c.2377C>A 7:g.55191761C>A EGFR ENST00000275493.6 3633 3236 1063624 1063624 979669 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17487277 surgery fresh/frozen NS 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 S0361 897613 815236 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15118125 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0009623-T01-IM5 2725517 2584338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A028-T-S18 2757395 2615998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876667 2876667 2731182 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 71 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0004678-T01-IM5 2721078 2579899 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1004982 1004982 922194 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211136 1211136 1123004 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 53 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004695-T01-IM5 2721097 2579918 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002709-T01-IM3 2718949 2577770 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51766357 COSM6924089 133269403 c.2893G>T p.V965L Substitution - Missense het 38 7:55201269-55201269 + - PATHOGENIC .82061 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Val965Leu ENST00000455089.5:c.2893G>T 7:g.55201269G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T521 2296252 2161855 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51822020 COSM4745530 133259424 c.2166_2167delinsGG p.S723G Substitution - Missense 38 7:55181310-55181311 + - Confirmed somatic variant 25344691 NS NS 62.83 ENSP00000415559.1:p.Ser723Gly ENST00000455089.5:c.2166_2167delinsGG 7:g.55181310_55181311delinsGG EGFR ENST00000275493.6 3633 3236 88 2630342 2490726 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51769145 COSM3266559 99415380 c.874G>A p.V292M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 27756406 surgery-fixed primary 48 ENSP00000275493.2:p.Val292Met ENST00000275493.6:c.874G>A 7:g.55154137G>A EGFR ENST00000275493.6 3633 3236 BK0016 2237570 2105074 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51768262 COSM26445 99377063 c.2300C>T p.A767V Substitution - Missense 38 7:55181309-55181309 + - PATHOGENIC .97799 Confirmed somatic variant 24504440 surgery - NOS NS ENSP00000275493.2:p.Ala767Val ENST00000275493.6:c.2300C>T 7:g.55181309C>T EGFR ENST00000275493.6 3633 3236 PD42110c 2894819 2749307 skin extremity NS NS malignant_melanoma nodular NS NS y COSV51822879 COSM4680399 99382634 c.2039G>A p.R680Q Substitution - Missense 38 7:55173102-55173102 + - PATHOGENIC .99814 Confirmed somatic variant 33024263 surgery-fixed metastasis ENSP00000275493.2:p.Arg680Gln ENST00000275493.6:c.2039G>A 7:g.55173102G>A EGFR ENST00000275493.6 3633 3236 2876597 2876597 2731112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010345-T02-IM5 2726112 2584933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790040 COSM6978158 133221155 c.2364_2365delinsTT p.L788_V789delinsFL Substitution - Missense het 38 7:55191748-55191749 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu788_Val789delinsPheLeu ENST00000455089.5:c.2364_2365delinsTT 7:g.55191748_55191749delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T3174 2658322 2518481 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 133212226 c.1445G>A p.R482Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 74.41 ENSP00000415559.1:p.Arg482Gln ENST00000455089.5:c.1445G>A 7:g.55161580G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009711-T01-IM5 2725587 2584408 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812807 2812807 2669221 liver NS NS NS other adenoma NS NS n COSV51845994 COSM5530405 132547619 c.1498G>A p.E500K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 31189995 surgery-fixed NS 9 ENSP00000395243.3:p.Glu500Lys ENST00000454757.6:c.1498G>A 7:g.55163734G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-0656-01 2178172 2046470 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 132550339 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 NS NS 48 ENSP00000395243.3:p.Ala244Asp ENST00000454757.6:c.731C>A 7:g.55154129C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-RD-A7BT-01 2263044 2130028 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99295752 COSM8178996 133228403 c.580G>A p.G194S Substitution - Missense 38 7:55152632-55152632 + - PATHOGENIC .99504 Confirmed somatic variant 541 NS primary 66 ENSP00000415559.1:p.Gly194Ser ENST00000455089.5:c.580G>A 7:g.55152632G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006054-T01-IM5 2722434 2581255 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000918-T01-IM3 2716255 2575076 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51799159 COSM747427 132570646 c.1631C>T p.P544L Substitution - Missense het 38 7:55165323-55165323 + - PATHOGENIC .95834 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Pro544Leu ENST00000454757.6:c.1631C>T 7:g.55165323C>T EGFR ENST00000275493.6 3633 3236 P-0000347-T01-IM3 2715085 2573906 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1211145 1211145 1123013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 38 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-MT-A67A-01 2193588 2061866 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51853450 COSM53290 99380220 c.2615A>G p.E872G Substitution - Missense 38 7:55191864-55191864 + - PATHOGENIC .986 Confirmed somatic variant 627 NS NS 85 ENSP00000275493.2:p.Glu872Gly ENST00000275493.6:c.2615A>G 7:g.55191864A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982775 982775 898494 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001245 1001245 918468 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011107-T01-IM5 2726736 2585557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 NB-1204 1898491 1787175 autonomic_ganglia NS NS NS neuroblastoma NS NS NS y COSV51767481 COSM1284692 132557901 c.1787C>A p.P596H Substitution - Missense 38 7:55172985-55172985 + - PATHOGENIC .97992 Confirmed somatic variant 23334666 NS NS ENSP00000395243.3:p.Pro596His ENST00000454757.6:c.1787C>A 7:g.55172985C>A EGFR ENST00000275493.6 3633 3236 1206717 1206717 1118595 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0000785-T01-IM3 2715984 2574805 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0002207-T01-IM3 2718499 2577320 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0003316-T01-IM5 2719809 2578630 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152787 2152787 2021797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152784 2152784 2021794 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2772383 2772383 2630573 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV99290341 COSM7347800 133255621 c.881G>A p.G294E Substitution - Missense 38 7:55156542-55156542 + - PATHOGENIC .99668 Confirmed somatic variant 29807833 circulating tumour NS ENSP00000415559.1:p.Gly294Glu ENST00000455089.5:c.881G>A 7:g.55156542G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SJHYPO052-D 2590140 2451270 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 132554159 c.1144C>T p.R382C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 23334668 blood-bone marrow NS 16.3 ENSP00000395243.3:p.Arg382Cys ENST00000454757.6:c.1144C>T 7:g.55157734C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 587220 1766747 1671067 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51792177 COSM1205050 132554159 c.1144C>T p.R382C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 22895193 surgery fresh/frozen primary ENSP00000395243.3:p.Arg382Cys ENST00000454757.6:c.1144C>T 7:g.55157734C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576891 COSM9396331 133217776 c.1265A>C p.K422T Substitution - Missense 38 7:55160240-55160240 + - NEUTRAL .10442 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000415559.1:p.Lys422Thr ENST00000455089.5:c.1265A>C 7:g.55160240A>C EGFR ENST00000275493.6 3633 3236 1284797 1284797 1196075 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51821681 COSM12989 99387485 c.2303G>A p.S768N Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98539 Confirmed somatic variant 19786660 surgery-fixed NS ENSP00000275493.2:p.Ser768Asn ENST00000275493.6:c.2303G>A 7:g.55181312G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876593 2876593 2731108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 133216269 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-76-4926-01 2120378 1994614 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 68 ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003850-T01-IM5 2720342 2579163 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD8733a 1588462 1509633 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia_with_ringed_sideroblasts NS n COSV51795335 COSM53232 133242193 c.1987A>G p.K663E Substitution - Missense 38 7:55173981-55173981 + - PATHOGENIC .98155 Confirmed somatic variant 24030381 NS NS ENSP00000415559.1:p.Lys663Glu ENST00000455089.5:c.1987A>G 7:g.55173981A>G EGFR ENST00000275493.6 3633 3236 TCGA-06-2561-01 1337880 1248265 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51841003 COSM3412168 99438249 c.445C>T p.R149W Substitution - Missense 38 7:55146626-55146626 + - PATHOGENIC .93775 Confirmed somatic variant 329 surgery fresh/frozen NS 53 ENSP00000275493.2:p.Arg149Trp ENST00000275493.6:c.445C>T 7:g.55146626C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 YUOTHO 2439352 2302193 skin NS NS NS malignant_melanoma NS NS NS y COSV51848994 COSM5407724 132561227 c.1566G>A p.M522I Substitution - Missense het 38 7:55163802-55163802 + - PATHOGENIC .89204 Confirmed somatic variant 26214590 fresh/frozen - NOS primary 87 ENSP00000395243.3:p.Met522Ile ENST00000454757.6:c.1566G>A 7:g.55163802G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010345-T01-IM5 2726113 2584934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1595812 1595812 1516609 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51767379 COSM85894 132557468 c.2392G>A p.V798I Substitution - Missense het 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 16551849 surgery-fixed NS 60 ENSP00000395243.3:p.Val798Ile ENST00000454757.6:c.2392G>A 7:g.55191776G>A EGFR ENST00000275493.6 3633 3236 P-0003425-T01-IM5 2719907 2578728 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51812540 COSM1451536 132566366 c.322A>G p.R108G Substitution - Missense 38 7:55143386-55143386 + - PATHOGENIC .72671 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000395243.3:p.Arg108Gly ENST00000454757.6:c.322A>G 7:g.55143386A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008757-T01-IM5 2724807 2583628 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 TCGA-CV-7252-01 2193523 2061801 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 627 NS NS 62 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 17234 1423805 1333833 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-IR-A3LA-01 2193391 2061669 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51796224 COSM4844514 133245588 c.1513G>C p.V505L Substitution - Missense 38 7:55163749-55163749 + - PATHOGENIC .98124 Confirmed somatic variant 415 NS NS 60 ENSP00000415559.1:p.Val505Leu ENST00000455089.5:c.1513G>C 7:g.55163749G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S001102 1027688 944664 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 132551880 c.652A>C p.T218P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Thr218Pro ENST00000454757.6:c.652A>C 7:g.55154050A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004225-T01-IM5 2720632 2579453 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV51771772 COSM6934070 133284198 c.1164T>A p.H388Q Substitution - Missense het 38 7:55160139-55160139 + - PATHOGENIC .93122 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.His388Gln ENST00000455089.5:c.1164T>A 7:g.55160139T>A EGFR ENST00000275493.6 3633 3236 2150408 2150408 2019477 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 66 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 CS1-C 2898363 2752647 endometrium NS NS NS carcinoma carcinosarcoma-malignant_mesodermal_mixed_tumour NS NS y COSV51806667 COSM6987130 99400907 c.1939G>A p.A647T Substitution - Missense 38 7:55173002-55173002 + - PATHOGENIC .99609 Confirmed somatic variant 33021035 surgery fresh/frozen NS 84 ENSP00000275493.2:p.Ala647Thr ENST00000275493.6:c.1939G>A 7:g.55173002G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010634-T01-IM5 2726322 2585143 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51847135 COSM6975718 133261714 c.3074G>C p.S1025T Substitution - Missense het 38 7:55202563-55202563 + - PATHOGENIC .94366 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ser1025Thr ENST00000455089.5:c.3074G>C 7:g.55202563G>C EGFR ENST00000275493.6 3633 3236 95504 1973048 1859292 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSV51812284 COSM1651737 99427251 c.821C>T p.T274M Substitution - Missense 38 7:55154084-55154084 + - PATHOGENIC .92031 Confirmed somatic variant 23680147 surgery - NOS primary ENSP00000275493.2:p.Thr274Met ENST00000275493.6:c.821C>T 7:g.55154084C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007901-T01-IM5 2724112 2582933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-28-1745-01 2178166 2046464 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99288542 COSM7459054 133244332 c.2897T>A p.V966E Substitution - Missense 38 7:55201273-55201273 + - PATHOGENIC .99252 Confirmed somatic variant 329 NS NS 76 ENSP00000415559.1:p.Val966Glu ENST00000455089.5:c.2897T>A 7:g.55201273T>A EGFR ENST00000275493.6 3633 3236 2152760 2152760 2021770 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 99378223 c.2327G>A p.R776H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Arg776His ENST00000275493.6:c.2327G>A 7:g.55181336G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876597 2876597 2731112 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-VS026-T1 2869846 2724843 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV51846033 COSM5530399 133226145 c.2621C>T p.P874L Substitution - Missense 38 7:55198771-55198771 + - PATHOGENIC .97363 Confirmed somatic variant 26950094 surgery fresh/frozen NS 58 ENSP00000415559.1:p.Pro874Leu ENST00000455089.5:c.2621C>T 7:g.55198771C>T EGFR ENST00000275493.6 3633 3236 1091705 1091705 1006527 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26136 178380446 c.? p.G863S Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS ENSP00000275493.2:p.Gly863Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CRC396 2730836 2589605 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV105863800 COSM10061888 133214431 c.1847C>G p.A616G Substitution - Missense 38 7:55173045-55173045 + - .53009 Confirmed somatic variant 26416732 xenograft metastasis 57 ENSP00000415559.1:p.Ala616Gly ENST00000455089.5:c.1847C>G 7:g.55173045C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S_TBL200_R6 2757770 2616344 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29106415 autopsy - NOS metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2696517 2696517 2555421 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28201779 surgery fresh/frozen NS 60 ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AR-A2LR-01 2187807 2056085 breast NS NS NS carcinoma NS NS NS y COSV51781835 COSM174732 133207258 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 414 NS NS 49 ENSP00000415559.1:p.Glu114Lys ENST00000455089.5:c.340G>A 7:g.55143404G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007076-T03-IM5 2723450 2582271 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS n COSV51860919 COSM6961890 132620937 c.458G>A p.S153N Substitution - Missense het 38 7:55151327-55151327 + - PATHOGENIC .89951 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ser153Asn ENST00000454757.6:c.458G>A 7:g.55151327G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152782 2152782 2021792 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 860 898395 816007 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 4991 915993 833392 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0012079-T01-IM5 2727221 2586042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 911963 911963 829455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15780185 NS NS 50 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DD-AAE3-01 2339647 2204630 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51766284 COSM28512 132550675 c.2095A>G p.I699V Substitution - Missense 38 7:55174767-55174767 + - PATHOGENIC .99591 Confirmed somatic variant 628 NS primary 50 ENSP00000395243.3:p.Ile699Val ENST00000454757.6:c.2095A>G 7:g.55174767A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-E1-A7YQ-01 2386259 2249091 central_nervous_system brain NS NS glioma NS NS NS y COSV99286607 COSM8256230 132619575 c.1859G>A p.G620D Substitution - Missense 38 7:55173057-55173057 + - PATHOGENIC .9747 Confirmed somatic variant 545 NS primary 58 ENSP00000395243.3:p.Gly620Asp ENST00000454757.6:c.1859G>A 7:g.55173057G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-VS091-T1 2869923 2724920 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51822575 COSM6932208 132560387 c.2639C>T p.S880F Substitution - Missense 38 7:55198789-55198789 + - NEUTRAL .37023 Confirmed somatic variant 26950094 surgery - NOS NS 90 ENSP00000395243.3:p.Ser880Phe ENST00000454757.6:c.2639C>T 7:g.55198789C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982774 982774 898493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51788343 COSM18441 132609147 c.2019_2020delinsTT p.G674C Substitution - Missense 38 7:55174013-55174014 + - Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2019_2020delinsTT 7:g.55174013_55174014delinsTT EGFR ENST00000275493.6 3633 3236 EXTERN_MELA_20140514_008 2839310 2695076 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV104577177 COSM9365746 99455188 c.1996C>T p.L666F Substitution - Missense 38 7:55173059-55173059 + - PATHOGENIC .98429 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000275493.2:p.Leu666Phe ENST00000275493.6:c.1996C>T 7:g.55173059C>T EGFR ENST00000275493.6 3633 3236 P-0001042-T01-IM3 2716511 2575332 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51787557 COSM6191456 99376546 c.1337C>T p.T446I Substitution - Missense het 38 7:55160177-55160177 + - NEUTRAL .13103 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr446Ile ENST00000275493.6:c.1337C>T 7:g.55160177C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GYWU_937 2771256 2629453 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211145 1211145 1123013 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 38 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000347-T01-IM3 2715085 2573906 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-XR-A8TF-01 2457496 2320333 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV99288624 COSM8419655 99418640 c.3484A>T p.S1162C Substitution - Missense 38 7:55205468-55205468 + - NEUTRAL .21616 Confirmed somatic variant 628 NS primary 74 ENSP00000275493.2:p.Ser1162Cys ENST00000275493.6:c.3484A>T 7:g.55205468A>T EGFR ENST00000275493.6 3633 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 CHG-98T 2634280 2494676 liver NS NS NS other neoplasm NS NS y COSV51850174 COSM6307834 99403493 c.350A>G p.Y117C Substitution - Missense 38 7:55143414-55143414 + - PATHOGENIC .98157 Confirmed somatic variant 660 NS primary 51 ENSP00000275493.2:p.Tyr117Cys ENST00000275493.6:c.350A>G 7:g.55143414A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD11341a 1749312 1654153 breast NS NS NS carcinoma ductal_carcinoma mucinous NS y COSV51807785 COSM5782738 132594001 c.1855A>T p.I619F Substitution - Missense 38 7:55173053-55173053 + - PATHOGENIC .88741 Confirmed somatic variant 652 NS NS ENSP00000395243.3:p.Ile619Phe ENST00000454757.6:c.1855A>T 7:g.55173053A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-GN-A266-06 2121796 1996032 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 132569945 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 540 NS NS 45 ENSP00000395243.3:p.His47Tyr ENST00000454757.6:c.139C>T 7:g.55142336C>T EGFR ENST00000275493.6 3633 3236 2115526 2115526 1989770 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451157 1451157 1375300 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2862414 2862414 2717596 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 31694833 circulating tumour primary 58 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51816377 COSM3412194 132548327 c.1651C>T p.P551S Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99531 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000395243.3:p.Pro551Ser ENST00000454757.6:c.1651C>T 7:g.55165343C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MSU3-c 2809980 2666642 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV99292326 COSM9176305 132574682 c.1444C>T p.R482W Substitution - Missense 38 7:55161579-55161579 + - NEUTRAL .28879 Confirmed somatic variant 26336987 surgery fresh/frozen primary 51 ENSP00000395243.3:p.Arg482Trp ENST00000454757.6:c.1444C>T 7:g.55161579C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004523-T01-IM5 2829761 2685576 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51780877 COSM26717 132548732 c.2444A>T p.K815I Substitution - Missense 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 30205045 surgery-fixed metastasis 58 ENSP00000395243.3:p.Lys815Ile ENST00000454757.6:c.2444A>T 7:g.55191828A>T EGFR ENST00000275493.6 3633 3236 APGI-AMP-2890 2866039 2721116 pancreas ampulla_of_Vater NS NS carcinoma ductal_carcinoma NS NS y COSV105111099 COSM9620623 99424953 c.661G>A p.G221R Substitution - Missense 38 7:55152578-55152578 + - NEUTRAL .36671 Confirmed somatic variant 26804919 surgery fresh/frozen NS ENSP00000275493.2:p.Gly221Arg ENST00000275493.6:c.661G>A 7:g.55152578G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DD-A73A-01 2194652 2062930 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51846765 COSM4916543 133209445 c.1097C>G p.P366R Substitution - Missense 38 7:55157687-55157687 + - PATHOGENIC .99735 Confirmed somatic variant 628 NS NS 71 ENSP00000415559.1:p.Pro366Arg ENST00000455089.5:c.1097C>G 7:g.55157687C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DY-A1DF-01 1651675 1566462 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV51776282 COSM1168015 133202278 c.2123C>T p.P708L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Confirmed somatic variant 375 NS primary 73 ENSP00000415559.1:p.Pro708Leu ENST00000455089.5:c.2123C>T 7:g.55174795C>T EGFR ENST00000275493.6 3633 3236 P-0010754-T01-IM5 2726435 2585256 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51805749 COSM6976991 99375210 c.2644G>A p.A882T Substitution - Missense het 38 7:55192784-55192784 + - PATHOGENIC .95513 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala882Thr ENST00000275493.6:c.2644G>A 7:g.55192784G>A EGFR ENST00000275493.6 3633 3236 TCGA-32-1991-01 2120347 1994583 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 60 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 2675054 2675054 2534329 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Confirmed somatic variant 29110836 surgery-fixed NS 53 ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-GN-A266-06 2121796 1996032 skin NS NS NS malignant_melanoma NS NS NS y COSV51830943 COSM3639753 132581709 c.2629G>A p.E877K Substitution - Missense 38 7:55198779-55198779 + - PATHOGENIC .98622 Confirmed somatic variant 540 NS NS 45 ENSP00000395243.3:p.Glu877Lys ENST00000454757.6:c.2629G>A 7:g.55198779G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-VS034-T2 2869859 2724856 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51802355 COSM6941144 132549822 c.1019C>T p.P340L Substitution - Missense 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 26950094 surgery - NOS NS 75 ENSP00000395243.3:p.Pro340Leu ENST00000454757.6:c.1019C>T 7:g.55156779C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003425-T01-IM5 2719907 2578728 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832145 COSM6493936 99406880 c.2389T>G p.C797G Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95801 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000275493.2:p.Cys797Gly ENST00000275493.6:c.2389T>G 7:g.55181398T>G EGFR ENST00000275493.6 3633 3236 1468560 1468560 1392311 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM28739 178379146 c.? p.D761Y Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Asp761Tyr EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009661-T01-IM5 2725553 2584374 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 P-0000918-T01-IM3 2716255 2575076 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 2372112 2372112 2234905 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_III anaplastic NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 25694352 surgery fresh/frozen NS 28 ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PC-9BRc1 2015227 1897435 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 23733853 cell-line NS ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812111 2812111 2668565 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 circulating tumour NS 73 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005763-T01-IM5 2722150 2580971 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1194723 1194723 1106618 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51853292 COSM29339 99431496 c.271A>C p.I91L Substitution - Missense 38 7:55143335-55143335 + - PATHOGENIC .99037 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000275493.2:p.Ile91Leu ENST00000275493.6:c.271A>C 7:g.55143335A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006846-T01-IM5 2723226 2582047 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T1154 2296082 2161685 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51814845 COSM4680396 132606330 c.1562C>T p.A521V Substitution - Missense 38 7:55163798-55163798 + - NEUTRAL .08918 Confirmed somatic variant 25344691 NS NS 68.33 ENSP00000395243.3:p.Ala521Val ENST00000454757.6:c.1562C>T 7:g.55163798C>T EGFR ENST00000275493.6 3633 3236 GBM12 2144553 2013767 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 24285547 surgery fresh/frozen primary 64 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 17747 1423850 1333878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1713239 1713239 1620973 pleura NS NS NS mesothelioma epithelial NS NS n COSV51779794 COSM53264 133215961 c.2039C>T p.T680M Substitution - Missense het 38 7:55174033-55174033 + - PATHOGENIC .97744 Confirmed somatic variant 22412050 surgery-fixed NS 59 ENSP00000415559.1:p.Thr680Met ENST00000455089.5:c.2039C>T 7:g.55174033C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2749088 2749088 2607791 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51779794 COSM53264 133215961 c.2039C>T p.T680M Substitution - Missense 38 7:55174033-55174033 + - PATHOGENIC .97744 Confirmed somatic variant 29360550 surgery-fixed NS 67 ENSP00000415559.1:p.Thr680Met ENST00000455089.5:c.2039C>T 7:g.55174033C>T EGFR ENST00000275493.6 3633 3236 TCGA-C5-A1BM-01 2193409 2061687 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51807983 COSM4826463 99433997 c.2432C>G p.S811C Substitution - Missense 38 7:55181441-55181441 + - PATHOGENIC .97792 Confirmed somatic variant 415 NS NS 78 ENSP00000275493.2:p.Ser811Cys ENST00000275493.6:c.2432C>G 7:g.55181441C>G EGFR ENST00000275493.6 3633 3236 P-0010345-T02-IM5 2726112 2584933 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0004691-T02-IM5 2721093 2579914 lung NS NS NS carcinoma mixed_adenosquamous_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 65 897198 814821 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A021-T-S14 2757380 2615995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 57 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2812108 2812108 2668564 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion NS 59 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1005016 1005016 922228 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982878 982878 898597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458703 1458703 1382678 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1109720 1109720 1023630 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 18372921 surgery-fixed primary 72 ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 2638656 2638656 2499029 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM4389219 178384668 c.? p.G796D Substitution - Missense + Yes Confirmed somatic variant 28572531 circulating tumour recurrent 56 ENSP00000275493.2:p.Gly796Asp EGFR ENST00000275493.6 3633 3236 1460101 1460101 1383978 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51799041 COSM52931 99408351 c.2195T>C p.I732T Substitution - Missense 38 7:55174732-55174732 + - PATHOGENIC .98814 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000275493.2:p.Ile732Thr ENST00000275493.6:c.2195T>C 7:g.55174732T>C EGFR ENST00000275493.6 3633 3236 2876591 2876591 2731106 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 99388191 c.2389T>A p.C797S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 74 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2389T>A 7:g.55181398T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2492723 2492723 2355338 skin NS NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 133212507 c.2890G>A p.D964N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000415559.1:p.Asp964Asn ENST00000455089.5:c.2890G>A 7:g.55201266G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471565 1471565 1395304 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S003577 1027697 944673 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 132548259 c.1652C>T p.P551L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000395243.3:p.Pro551Leu ENST00000454757.6:c.1652C>T 7:g.55165344C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S001071 1027700 944676 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 TCGA-71-8520-01 2194759 2063037 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 417 NS NS 60 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982888 982888 898607 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982889 982889 898608 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 PD7044a 1504255 1427133 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51826432 COSM4384121 99416578 c.1570G>A p.V524I Substitution - Missense 38 7:55161570-55161570 + - PATHOGENIC .78109 Confirmed somatic variant 24030381 NS NS ENSP00000275493.2:p.Val524Ile ENST00000275493.6:c.1570G>A 7:g.55161570G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836217 COSM7314292 132575719 c.1279G>T p.A427S Substitution - Missense 38 7:55160254-55160254 + - PATHOGENIC .97432 Confirmed somatic variant 660 NS primary 46 ENSP00000395243.3:p.Ala427Ser ENST00000454757.6:c.1279G>T 7:g.55160254G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008757-T01-IM5 2724807 2583628 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51859662 COSM6964726 132556704 c.2106A>C p.L702F Substitution - Missense het 38 7:55174778-55174778 + - PATHOGENIC .7109 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu702Phe ENST00000454757.6:c.2106A>C 7:g.55174778A>C EGFR ENST00000275493.6 3633 3236 TG77905 2823147 2679001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM97027 178382712 c.? p.L858M Substitution - Missense + - Confirmed somatic variant 28818608 surgery-fixed NS 74 ENSP00000275493.2:p.Leu858Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1505362 1505362 1428240 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51779291 COSM26446 133217001 c.2389A>G p.N797D Substitution - Missense 38 7:55191773-55191773 + - PATHOGENIC .986 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000415559.1:p.Asn797Asp ENST00000455089.5:c.2389A>G 7:g.55191773A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DUMC-18 2748715 2607418 central_nervous_system frontoparietal NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 29802247 surgery fresh/frozen NS 52 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FG-A87Q-01 2339613 2204596 central_nervous_system brain NS NS glioma NS NS NS y COSV99289246 COSM8268187 132551517 c.653C>T p.T218I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 545 NS primary 61 ENSP00000395243.3:p.Thr218Ile ENST00000454757.6:c.653C>T 7:g.55154051C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CTS177 2393057 2255888 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002524-T01-IM3 2718790 2577611 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-55-8506-01 2194766 2063044 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 62 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206722 1206722 1118600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876063 2876063 2730578 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A014-T-S30 2758135 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0016773-T01-IM6 2830871 2686686 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV104577017 COSM9359622 99396619 c.743G>A p.C248Y Substitution - Missense 38 7:55152660-55152660 + - PATHOGENIC .99504 Confirmed somatic variant 30205045 surgery-fixed primary 77 ENSP00000275493.2:p.Cys248Tyr ENST00000275493.6:c.743G>A 7:g.55152660G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T164221 2658574 2518733 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51767379 COSM85894 132557468 c.2392G>A p.V798I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 27149842 NS NS 72.66 ENSP00000395243.3:p.Val798Ile ENST00000454757.6:c.2392G>A 7:g.55191776G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-CV-7252-01 2193523 2061801 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 627 NS NS 62 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 PD6883a 1504094 1426972 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia NS n COSV51850592 COSM4384117 99384930 c.754C>G p.R252G Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .93941 Confirmed somatic variant 24030381 NS NS ENSP00000275493.2:p.Arg252Gly ENST00000275493.6:c.754C>G 7:g.55154017C>G EGFR ENST00000275493.6 3633 3236 P-0006846-T01-IM5 2723226 2582047 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51781750 COSM6954369 99401988 c.954G>A p.M318I Substitution - Missense het 38 7:55155894-55155894 + - PATHOGENIC .91367 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Met318Ile ENST00000275493.6:c.954G>A 7:g.55155894G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471551 1471551 1395290 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005006 1005006 922218 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982868 982868 898587 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471546 1471546 1395285 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 914589 914589 832038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920107 920107 837186 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery-fixed NS 37 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103780 1103780 1018032 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 914581 914581 832030 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 99375713 c.2318A>T p.H773L Substitution - Missense het 38 7:55181327-55181327 + - PATHOGENIC .98404 Confirmed somatic variant 15788655 surgery fresh/frozen primary 72 ENSP00000275493.2:p.His773Leu ENST00000275493.6:c.2318A>T 7:g.55181327A>T EGFR ENST00000275493.6 3633 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-28-1745-01 2178166 2046464 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99288542 COSM7459054 132583285 c.2897T>A p.V966E Substitution - Missense 38 7:55201273-55201273 + - PATHOGENIC .99252 Confirmed somatic variant 329 NS NS 76 ENSP00000395243.3:p.Val966Glu ENST00000454757.6:c.2897T>A 7:g.55201273T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1595812 1595812 1516609 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51848710 COSM26438 132561077 c.2485G>A p.G829S Substitution - Missense het 38 7:55191869-55191869 + - PATHOGENIC .98912 Confirmed somatic variant 16551849 surgery-fixed NS 60 ENSP00000395243.3:p.Gly829Ser ENST00000454757.6:c.2485G>A 7:g.55191869G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0016773-T01-IM6 2830871 2686686 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV104577017 COSM9359622 132566157 c.608G>A p.C203Y Substitution - Missense 38 7:55152660-55152660 + - PATHOGENIC .99504 Confirmed somatic variant 30205045 surgery-fixed primary 77 ENSP00000395243.3:p.Cys203Tyr ENST00000454757.6:c.608G>A 7:g.55152660G>A EGFR ENST00000275493.6 3633 3236 2665866 2665866 2525574 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM6842525 178387763 c.? p.Q181H Substitution - Missense + - Confirmed somatic variant 28979142 surgery - NOS NS EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001042-T01-IM3 2716511 2575332 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51787557 COSM6191456 133204732 c.1202C>T p.T401I Substitution - Missense het 38 7:55160177-55160177 + - NEUTRAL .13103 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr401Ile ENST00000455089.5:c.1202C>T 7:g.55160177C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-71-8520-01 2194759 2063037 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 417 NS NS 60 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CHG-98T 2634280 2494676 liver NS NS NS other neoplasm NS NS y COSV51850174 COSM6307834 132571495 c.350A>G p.Y117C Substitution - Missense 38 7:55143414-55143414 + - PATHOGENIC .98157 Confirmed somatic variant 660 NS primary 51 ENSP00000395243.3:p.Tyr117Cys ENST00000454757.6:c.350A>G 7:g.55143414A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 YUSCO 2013686 1896318 skin NS NS NS malignant_melanoma NS NS NS y COSV51778830 COSM1698691 133207060 c.1063G>A p.E355K Substitution - Missense het 38 7:55156823-55156823 + - PATHOGENIC .99571 Confirmed somatic variant 22842228 NS NS ENSP00000415559.1:p.Glu355Lys ENST00000455089.5:c.1063G>A 7:g.55156823G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1505362 1505362 1428240 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51797142 COSM87246 133273200 c.2426C>T p.T809I Substitution - Missense 38 7:55191810-55191810 + - PATHOGENIC .97885 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000415559.1:p.Thr809Ile ENST00000455089.5:c.2426C>T 7:g.55191810C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1472952 1472952 1396651 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51848710 COSM26438 133217212 c.2485G>A p.G829S Substitution - Missense 38 7:55191869-55191869 + - PATHOGENIC .98912 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000415559.1:p.Gly829Ser ENST00000455089.5:c.2485G>A 7:g.55191869G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM_IV-19 2354288 2218446 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009042-T01-IM5 2725031 2583852 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 133206440 c.2113G>C p.A705P Substitution - Missense het 38 7:55174785-55174785 + - PATHOGENIC .99356 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala705Pro ENST00000455089.5:c.2113G>C 7:g.55174785G>C EGFR ENST00000275493.6 3633 3236 CHG-12-12649T 2634294 2494690 liver NS NS NS other neoplasm NS NS y COSV51767687 COSM6191352 99373482 c.1747G>A p.A583T Substitution - Missense 38 7:55165304-55165304 + - PATHOGENIC .98656 Confirmed somatic variant 660 NS primary 50 ENSP00000275493.2:p.Ala583Thr ENST00000275493.6:c.1747G>A 7:g.55165304G>A EGFR ENST00000275493.6 3633 3236 P-0009661-T01-IM5 2725553 2584374 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 2862457 2862457 2717620 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSM24273 178386680 c.? p.R748K Substitution - Missense + - Confirmed somatic variant 31694833 surgery-fixed primary 62 ENSP00000275493.2:p.Arg748Lys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002085-T02-IM5 2719477 2578298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 NS metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002491-T01-IM3 2718763 2577584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005511-T02-IM5 2721904 2580725 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51836402 COSM6944131 132566103 c.2219C>G p.T740S Substitution - Missense het 38 7:55181363-55181363 + - PATHOGENIC .951 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Thr740Ser ENST00000454757.6:c.2219C>G 7:g.55181363C>G EGFR ENST00000275493.6 3633 3236 P-0004104-T01-IM5 2829691 2685506 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51846321 COSM6933335 99448223 c.1908T>G p.C636W Substitution - Missense 38 7:55171202-55171202 + - .63273 Confirmed somatic variant 30205045 surgery-fixed metastasis 32 ENSP00000275493.2:p.Cys636Trp ENST00000275493.6:c.1908T>G 7:g.55171202T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006952-T01-IM5 2723330 2582151 skin NS NS NS malignant_melanoma NS NS NS n COSV51774288 COSM6906389 132560534 c.1121_1122delinsTT p.A374V Substitution - Missense het 38 7:55157711-55157712 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala374Val ENST00000454757.6:c.1121_1122delinsTT 7:g.55157711_55157712delinsTT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0016773-T01-IM6 2830871 2686686 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV104577018 COSM9359626 132566173 c.3082C>A p.P1028T Substitution - Missense 38 7:55202571-55202571 + - PATHOGENIC .97286 Confirmed somatic variant 30205045 surgery-fixed primary 77 ENSP00000395243.3:p.Pro1028Thr ENST00000454757.6:c.3082C>A 7:g.55202571C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-HD-7832-01 2193665 2061943 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99286255 COSM8295362 132588656 c.2765A>C p.E922A Substitution - Missense 38 7:55200367-55200367 + - PATHOGENIC .99358 Confirmed somatic variant 627 NS NS 52 ENSP00000395243.3:p.Glu922Ala ENST00000454757.6:c.2765A>C 7:g.55200367A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005114-T01-IM5 2721517 2580338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51817830 COSM6941076 133232705 c.2465A>C p.K822T Substitution - Missense het 38 7:55191849-55191849 + - PATHOGENIC .9501 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Lys822Thr ENST00000455089.5:c.2465A>C 7:g.55191849A>C EGFR ENST00000275493.6 3633 3236 1008291 1008291 925485 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM21336 178386265 c.? p.G729E Substitution - Missense + - Confirmed somatic variant 16547470 surgery-fixed primary ENSP00000275493.2:p.Gly729Glu EGFR ENST00000275493.6 3633 3236 23 2699404 2558308 skin NS NS NS malignant_melanoma NS NS NS n COSV51774288 COSM6906389 99388629 c.1256_1257delinsTT p.A419V Substitution - Missense het 38 7:55157711-55157712 + - Confirmed somatic variant 29420467 surgery-fixed NS ENSP00000275493.2:p.Ala419Val ENST00000275493.6:c.1256_1257delinsTT 7:g.55157711_55157712delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-32-1991-01 2120347 1994583 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 60 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876666 2876666 2731181 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51789261 COSM12986 132561937 c.2294G>A p.G765D Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98244 Confirmed somatic variant 29506987 pleural effusion NS 64 ENSP00000395243.3:p.Gly765Asp ENST00000454757.6:c.2294G>A 7:g.55181438G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 945536 945536 862171 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51788393 COSM13979 133219516 c.2035G>A p.G679S Substitution - Missense het 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 16166444 surgery-fixed primary 57 ENSP00000415559.1:p.Gly679Ser ENST00000455089.5:c.2035G>A 7:g.55174029G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008257-T01-IM5 2724396 2583217 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766389 COSM43067 132572320 c.739G>T p.V247L Substitution - Missense het 38 7:55154137-55154137 + - PATHOGENIC .98997 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Val247Leu ENST00000454757.6:c.739G>T 7:g.55154137G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 100097 2807613 2664314 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51841863 COSM6913649 132550692 c.3280C>T p.L1094F Substitution - Missense 38 7:55205399-55205399 + - PATHOGENIC .96614 Confirmed somatic variant 24807215 surgery fresh/frozen primary 62 ENSP00000395243.3:p.Leu1094Phe ENST00000454757.6:c.3280C>T 7:g.55205399C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1595807 1595807 1516604 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51841095 COSM133588 132567838 c.2135A>G p.K712R Substitution - Missense hom 38 7:55174807-55174807 + - PATHOGENIC .9946 Confirmed somatic variant 16551849 surgery-fixed NS 66 ENSP00000395243.3:p.Lys712Arg ENST00000454757.6:c.2135A>G 7:g.55174807A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006115-T01-IM5 2722495 2581316 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51836136 COSM5574310 132566153 c.2764G>A p.E922K Substitution - Missense het 38 7:55200366-55200366 + - PATHOGENIC .99379 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Glu922Lys ENST00000454757.6:c.2764G>A 7:g.55200366G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SJALL043850-R 2824118 2679946 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV51836136 COSM5574310 132566153 c.2764G>A p.E922K Substitution - Missense 38 7:55200366-55200366 + - PATHOGENIC .99379 Confirmed somatic variant 31697823 blood-bone marrow recurrent 12.84 ENSP00000395243.3:p.Glu922Lys ENST00000454757.6:c.2764G>A 7:g.55200366G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SF268 1998472 1883544 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 23856246 cell-line primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-OL-A97C-01 2386126 2248958 breast NS NS NS carcinoma NS NS NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 414 NS primary 67 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-FG-A87Q-01 2339613 2204596 central_nervous_system brain NS NS glioma NS NS NS y COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 545 NS primary 61 ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003456-T01-IM5 2719933 2578754 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-QH-A6XC-01 2263268 2130252 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS primary 48 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 TCGA-GF-A6C9-06 2339468 2204451 skin NS NS NS malignant_melanoma NS NS NS y COSV51778029 COSM6268 99381060 c.2257C>T p.P753S Substitution - Missense 38 7:55174794-55174794 + - PATHOGENIC .98527 Confirmed somatic variant 540 NS NS 78 ENSP00000275493.2:p.Pro753Ser ENST00000275493.6:c.2257C>T 7:g.55174794C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 ESCC_61 2479566 2342326 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51828987 COSM5632947 133207303 c.2006A>C p.K669T Substitution - Missense 38 7:55174000-55174000 + - PATHOGENIC .9691 Confirmed somatic variant 26873401 NS NS 53 ENSP00000415559.1:p.Lys669Thr ENST00000455089.5:c.2006A>C 7:g.55174000A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005094-T01-IM5 2721497 2580318 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 Pat_01_A 2492837 2355451 NS NS NS NS malignant_melanoma NS NS NS y COSV51817615 COSM5872885 99406337 c.2789G>A p.G930E Substitution - Missense 38 7:55198804-55198804 + - PATHOGENIC .99081 Confirmed somatic variant 24265153 surgery-fixed NS 45 ENSP00000275493.2:p.Gly930Glu ENST00000275493.6:c.2789G>A 7:g.55198804G>A EGFR ENST00000275493.6 3633 3236 914581 914581 832030 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense het 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 15788655 surgery fresh/frozen primary 72 ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 HCC-JP-457-T 2746985 2605688 liver NS NS NS other neoplasm NS NS y COSV51770509 COSM7191105 99412718 c.1870T>G p.C624G Substitution - Missense 38 7:55165427-55165427 + - PATHOGENIC .99836 Confirmed somatic variant 323 NS primary 77 ENSP00000275493.2:p.Cys624Gly ENST00000275493.6:c.1870T>G 7:g.55165427T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0211-01 1910206 1798497 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 133206822 c.652A>C p.T218P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 fresh/frozen - NOS primary 48 ENSP00000415559.1:p.Thr218Pro ENST00000455089.5:c.652A>C 7:g.55154050A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003169-T01-IM5 2719662 2578483 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 A065-T-S18 2757403 2616000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876602 2876602 2731117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 99388191 c.2389T>A p.C797S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 57 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2389T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Au2 2466841 2329672 skin scalp NS NS malignant_melanoma desmoplastic NS NS y COSV51779748 COSM3639716 132569945 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26343386 surgery fresh/frozen NS 85 ENSP00000395243.3:p.His47Tyr ENST00000454757.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM7-I1 2813443 2669835 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772147 COSM375343 133220930 c.1799C>G p.S600C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000415559.1:p.Ser600Cys ENST00000455089.5:c.1799C>G 7:g.55172997C>G EGFR ENST00000275493.6 3633 3236 TARGET-30-PALUDH-01A-01W 2195523 2063801 autonomic_ganglia NS NS NS neuroblastoma NS NS NS y COSV51767481 COSM1284692 99385507 c.1922C>A p.P641H Substitution - Missense 38 7:55172985-55172985 + - PATHOGENIC .97992 Confirmed somatic variant 584 NS NS ENSP00000275493.2:p.Pro641His ENST00000275493.6:c.1922C>A 7:g.55172985C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005913-T01-IM5 2722296 2581117 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS n COSV51859214 COSM6946886 132549856 c.3461G>C p.R1154T Substitution - Missense het 38 7:55205580-55205580 + - PATHOGENIC .9752 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Arg1154Thr ENST00000454757.6:c.3461G>C 7:g.55205580G>C EGFR ENST00000275493.6 3633 3236 P-0002964-T02-IM3 2719172 2577993 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51843252 COSM6925373 99429011 c.3022G>T p.D1008Y Substitution - Missense het 38 7:55201263-55201263 + - PATHOGENIC .98531 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Asp1008Tyr ENST00000275493.6:c.3022G>T 7:g.55201263G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 HCC-JP-457-T 2746985 2605688 liver NS NS NS other neoplasm NS NS y COSV51770509 COSM7191105 133239095 c.1735T>G p.C579G Substitution - Missense 38 7:55165427-55165427 + - PATHOGENIC .99836 Confirmed somatic variant 323 NS primary 77 ENSP00000415559.1:p.Cys579Gly ENST00000455089.5:c.1735T>G 7:g.55165427T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T1244 2658449 2518608 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 132556268 c.1445G>A p.R482Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 62.75 ENSP00000395243.3:p.Arg482Gln ENST00000454757.6:c.1445G>A 7:g.55161580G>A EGFR ENST00000275493.6 3633 3236 1120295 1120295 1033451 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51774569 COSM27096 99419937 c.3034G>C p.D1012H Substitution - Missense 38 7:55201275-55201275 + - PATHOGENIC .99621 Confirmed somatic variant 18478265 surgery fresh/frozen NS ENSP00000275493.2:p.Asp1012His ENST00000275493.6:c.3034G>C 7:g.55201275G>C EGFR ENST00000275493.6 3633 3236 P-0002580-T01-IM3 2718839 2577660 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004607-T02-IM5 2721004 2579825 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152789 2152789 2021799 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003569-T01-IM5 2720054 2578875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152760 2152760 2021770 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-C5-A1BM-01 2193409 2061687 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51807972 COSM4826400 99433991 c.2367C>G p.I789M Substitution - Missense 38 7:55181376-55181376 + - PATHOGENIC .85141 Confirmed somatic variant 415 NS NS 78 ENSP00000275493.2:p.Ile789Met ENST00000275493.6:c.2367C>G 7:g.55181376C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876606 2876606 2731121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 132563558 c.2239C>T p.L747F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000395243.3:p.Leu747Phe ENST00000454757.6:c.2239C>T 7:g.55181383C>T EGFR ENST00000275493.6 3633 3236 P-0004607-T03-IM5 2721003 2579824 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1460147 1460147 1384024 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1001245 1001245 918468 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0005845-T01-IM5 2722230 2581051 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489259 1489259 1412417 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1001246 1001246 918469 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1005001 1005001 922213 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2906646 2906646 2760897 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29616327 surgery-fixed metastasis 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1004998 1004998 922210 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982775 982775 898494 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1005010 1005010 922222 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 702 898393 816005 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004104-T01-IM5 2829691 2685506 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51846321 COSM6933335 133271699 c.1773T>G p.C591W Substitution - Missense 38 7:55171202-55171202 + - .63273 Confirmed somatic variant 30205045 surgery-fixed metastasis 32 ENSP00000415559.1:p.Cys591Trp ENST00000455089.5:c.1773T>G 7:g.55171202T>G EGFR ENST00000275493.6 3633 3236 1690841 1690841 1599108 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 99387971 c.1474A>C p.S492R Substitution - Missense het 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 22270724 surgery - NOS recurrent 64 ENSP00000275493.2:p.Ser492Arg ENST00000275493.6:c.1474A>C 7:g.55160314A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0008849-T01-IM5 2724881 2583702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51786456 COSM6954013 132578470 c.2129C>G p.A710G Substitution - Missense het 38 7:55174801-55174801 + - PATHOGENIC .99346 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala710Gly ENST00000454757.6:c.2129C>G 7:g.55174801C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1120295 1120295 1033451 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51774569 COSM27096 133244959 c.2899G>C p.D967H Substitution - Missense 38 7:55201275-55201275 + - PATHOGENIC .99621 Confirmed somatic variant 18478265 surgery fresh/frozen NS ENSP00000415559.1:p.Asp967His ENST00000455089.5:c.2899G>C 7:g.55201275G>C EGFR ENST00000275493.6 3633 3236 TCGA-12-0656-01 2178172 2046470 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 99377226 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 NS NS 48 ENSP00000275493.2:p.Ala289Asp ENST00000275493.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009239-T01-IM5 2725198 2584019 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51792469 COSM6967655 133226504 c.1472T>A p.V491E Substitution - Missense het 38 7:55161607-55161607 + - PATHOGENIC .99007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Val491Glu ENST00000455089.5:c.1472T>A 7:g.55161607T>A EGFR ENST00000275493.6 3633 3236 SC_9028 2467372 2330203 prostate NS NS NS carcinoma NS NS NS y COSV51850909 COSM5557485 99391067 c.2338A>G p.I780V Substitution - Missense het 38 7:55181347-55181347 + - PATHOGENIC .9793 Confirmed somatic variant 26000489 surgery - NOS metastasis 71 ENSP00000275493.2:p.Ile780Val ENST00000275493.6:c.2338A>G 7:g.55181347A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 MM18T 2457741 2320578 endometrium NS NS NS carcinoma carcinosarcoma-malignant_mesodermal_mixed_tumour NS NS n COSV51810684 COSM5415932 132562232 c.2854T>G p.F952V Substitution - Missense 38 7:55201230-55201230 + - PATHOGENIC .9773 Confirmed somatic variant 25233892 surgery-fixed primary 59 ENSP00000395243.3:p.Phe952Val ENST00000454757.6:c.2854T>G 7:g.55201230T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FR-A8YC-06 2263445 2130429 skin NS NS NS malignant_melanoma NS NS NS y COSV51772860 COSM5872872 133241196 c.548C>T p.P183L Substitution - Missense 38 7:55152600-55152600 + - PATHOGENIC .99115 Confirmed somatic variant 540 NS NS 78 ENSP00000415559.1:p.Pro183Leu ENST00000455089.5:c.548C>T 7:g.55152600C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000922-T01-IM3 2716264 2575085 skin NS NS NS malignant_melanoma NS NS NS n COSV51862272 COSM6913539 133262517 c.2567G>A p.G856E Substitution - Missense het 38 7:55198717-55198717 + - PATHOGENIC .99414 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Gly856Glu ENST00000455089.5:c.2567G>A 7:g.55198717G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51808387 COSM3412196 99393769 c.1793G>C p.G598A Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000275493.2:p.Gly598Ala ENST00000275493.6:c.1793G>C 7:g.55165350G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2014_Lung_sq_70_T 2744941 2603644 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 48 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 2876593 2876593 2731108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 99388191 c.2389T>A p.C797S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2389T>A 7:g.55181398T>A EGFR ENST00000275493.6 3633 3236 PD11341a 1749312 1654153 breast NS NS NS carcinoma ductal_carcinoma mucinous NS y COSV51807785 COSM5782738 99433719 c.1990A>T p.I664F Substitution - Missense 38 7:55173053-55173053 + - PATHOGENIC .88741 Confirmed somatic variant 652 NS NS ENSP00000275493.2:p.Ile664Phe ENST00000275493.6:c.1990A>T 7:g.55173053A>T EGFR ENST00000275493.6 3633 3236 TCGA-SL-A6JA-01 2386253 2249085 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99293220 COSM8830926 99422355 c.2555A>C p.K852T Substitution - Missense 38 7:55191804-55191804 + - PATHOGENIC .98276 Confirmed somatic variant 419 NS primary 77 ENSP00000275493.2:p.Lys852Thr ENST00000275493.6:c.2555A>C 7:g.55191804A>C EGFR ENST00000275493.6 3633 3236 CC28 2766422 2624641 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV99034446 COSM7342224 99413359 c.2421C>A p.D807E Substitution - Missense 38 7:55181430-55181430 + - PATHOGENIC .94178 Confirmed somatic variant 29844865 surgery fresh/frozen NS 56 ENSP00000275493.2:p.Asp807Glu ENST00000275493.6:c.2421C>A 7:g.55181430C>A EGFR ENST00000275493.6 3633 3236 1451156 1451156 1375299 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 945815 945815 862341 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 16144918 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 945809 945809 862335 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 16144918 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468634 1468634 1392385 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2115516 2115516 1989760 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2115527 2115527 1989771 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-15-0742-01 1338018 1248403 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51827490 COSM39163 99397529 c.1907G>A p.C636Y Substitution - Missense 38 7:55171201-55171201 + - PATHOGENIC .98251 Confirmed somatic variant 329 surgery fresh/frozen NS 65 ENSP00000275493.2:p.Cys636Tyr ENST00000275493.6:c.1907G>A 7:g.55171201G>A EGFR ENST00000275493.6 3633 3236 2665869 2665869 2525577 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM6842528 178389849 c.? p.N528D Substitution - Missense + - Confirmed somatic variant 28979142 surgery - NOS NS EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EE-A2GO-06 2121665 1995901 skin NS NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 132556505 c.2890G>A p.D964N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 540 NS NS 66 ENSP00000395243.3:p.Asp964Asn ENST00000454757.6:c.2890G>A 7:g.55201266G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003169-T01-IM5 2719662 2578483 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004987 1004987 922199 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982786 982786 898505 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-MP-A4SW-01 2194827 2063105 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 53 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CH-LA8 2211434 2079637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24449147 surgery fresh/frozen NS 67 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 961852 961852 878136 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16467080 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1103793 1103793 1018045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1489243 1489243 1412401 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 69 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CT207 2393063 2255894 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 71 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876042 2876042 2730557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 43 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876665 2876665 2731180 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 42 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AR-A0TV-01 1779493 1683492 breast NS NS NS carcinoma NS NS NS y COSV99293406 COSM7679798 132581148 c.1442G>C p.C481S Substitution - Missense 38 7:55161577-55161577 + - PATHOGENIC .9951 Confirmed somatic variant 414 fresh/frozen - NOS primary 66 ENSP00000395243.3:p.Cys481Ser ENST00000454757.6:c.1442G>C 7:g.55161577G>C EGFR ENST00000275493.6 3633 3236 D023M059 2788448 2645740 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSV51802272 COSM13425 99394305 c.2305G>A p.V769M Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .98024 Confirmed somatic variant 28120820 surgery-fixed metastasis ENSP00000275493.2:p.Val769Met ENST00000275493.6:c.2305G>A 7:g.55181314G>A EGFR ENST00000275493.6 3633 3236 TCGA-A2-A4S3-01 2187874 2056152 breast NS NS NS carcinoma NS NS NS y COSV51810209 COSM3833026 99379437 c.941A>G p.D314G Substitution - Missense 38 7:55155881-55155881 + - PATHOGENIC .96368 Confirmed somatic variant 414 NS NS 59 ENSP00000275493.2:p.Asp314Gly ENST00000275493.6:c.941A>G 7:g.55155881A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876630 2876630 2731145 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S_TBL200_R3 2757767 2616341 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29106415 surgery - NOS metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876051 2876051 2730566 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 78 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 CTS25 2393067 2255898 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 25189529 surgery fresh/frozen NS 67 ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DD-A1EK-01 2194557 2062835 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51801820 COSM4934357 132595049 c.3313A>T p.T1105S Substitution - Missense 38 7:55205432-55205432 + - NEUTRAL .25214 Confirmed somatic variant 628 NS NS 64 ENSP00000395243.3:p.Thr1105Ser ENST00000454757.6:c.3313A>T 7:g.55205432A>T EGFR ENST00000275493.6 3633 3236 1091699 1091699 1006521 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM23613 178378830 c.? p.G719D Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS ENSP00000275493.2:p.Gly719Asp EGFR ENST00000275493.6 3633 3236 P-0003702-T02-IM5 2829639 2685454 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51831642 COSM1496684 99388394 c.988G>A p.E330K Substitution - Missense 38 7:55155928-55155928 + - PATHOGENIC .94538 Confirmed somatic variant 30205045 surgery-fixed metastasis 50 ENSP00000275493.2:p.Glu330Lys ENST00000275493.6:c.988G>A 7:g.55155928G>A EGFR ENST00000275493.6 3633 3236 P-0008246-T02-IM5 2724392 2583213 skin NS NS NS malignant_melanoma NS NS NS n COSV51776967 COSM6963220 99390712 c.1930C>T p.P644S Substitution - Missense het 38 7:55172993-55172993 + - PATHOGENIC .96242 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Pro644Ser ENST00000275493.6:c.1930C>T 7:g.55172993C>T EGFR ENST00000275493.6 3633 3236 5-VS091-T1 2869923 2724920 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51822575 COSM6932208 99388446 c.2774C>T p.S925F Substitution - Missense 38 7:55198789-55198789 + - NEUTRAL .37023 Confirmed somatic variant 26950094 surgery - NOS NS 90 ENSP00000275493.2:p.Ser925Phe ENST00000275493.6:c.2774C>T 7:g.55198789C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000657-T02-IM5 2719370 2578191 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 133220832 c.1658G>C p.G553A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Gly553Ala ENST00000455089.5:c.1658G>C 7:g.55165350G>C EGFR ENST00000275493.6 3633 3236 2591469 2591469 2452429 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2730911 2730911 2589680 skin acral NS NS malignant_melanoma in_situ_melanotic_neoplasm NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 28870692 surgery - NOS NS 50 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2372112 2372112 2234905 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_III anaplastic NS n COSV51822289 COSM42977 99402277 c.315G>T p.Q105H Substitution - Missense 38 7:55143379-55143379 + - PATHOGENIC .90579 Confirmed somatic variant 25694352 surgery fresh/frozen NS 28 ENSP00000275493.2:p.Gln105His ENST00000275493.6:c.315G>T 7:g.55143379G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002580-T01-IM3 2718839 2577660 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2675078 2675078 2534353 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 29110836 surgery-fixed recurrent 70 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591421 2591421 2452381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 DUMC-18 2748715 2607418 central_nervous_system frontoparietal NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 29802247 surgery fresh/frozen NS 52 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 2901989 2901989 2756229 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM5010368 178378709 c.? p.C797S Substitution - Missense + Yes Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Cys797Ser EGFR ENST00000275493.6 3633 3236 2901986 2901986 2756229 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Leu861Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-SL-A6JA-01 2386253 2249085 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99293220 COSM8830926 133246892 c.2420A>C p.K807T Substitution - Missense 38 7:55191804-55191804 + - PATHOGENIC .98276 Confirmed somatic variant 419 NS primary 77 ENSP00000415559.1:p.Lys807Thr ENST00000455089.5:c.2420A>C 7:g.55191804A>C EGFR ENST00000275493.6 3633 3236 P-0002709-T01-IM3 2718949 2577770 lung NS NS NS carcinoma large_cell_carcinoma NS NS n COSV51766357 COSM6924089 99445990 c.3028G>T p.V1010L Substitution - Missense het 38 7:55201269-55201269 + - PATHOGENIC .82061 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Val1010Leu ENST00000275493.6:c.3028G>T 7:g.55201269G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-EA-A410-01 2262924 2129908 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51769145 COSM3266559 133241176 c.739G>A p.V247M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 415 NS primary 51 ENSP00000415559.1:p.Val247Met ENST00000455089.5:c.739G>A 7:g.55154137G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0650-01 2120258 1994494 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 329 NS NS 39 ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 P-0006115-T01-IM5 2722495 2581316 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51836136 COSM5574310 99396611 c.2899G>A p.E967K Substitution - Missense het 38 7:55200366-55200366 + - PATHOGENIC .99379 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Glu967Lys ENST00000275493.6:c.2899G>A 7:g.55200366G>A EGFR ENST00000275493.6 3633 3236 SJALL043850-R 2824118 2679946 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV51836136 COSM5574310 99396611 c.2899G>A p.E967K Substitution - Missense 38 7:55200366-55200366 + - PATHOGENIC .99379 Confirmed somatic variant 31697823 blood-bone marrow recurrent 12.84 ENSP00000275493.2:p.Glu967Lys ENST00000275493.6:c.2899G>A 7:g.55200366G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2492701 2492701 2355316 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 133227476 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000415559.1:p.His47Tyr ENST00000455089.5:c.139C>T 7:g.55142336C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460139 1460139 1384016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 132549396 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000395243.3:p.Pro803Leu ENST00000454757.6:c.2408C>T 7:g.55191792C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0013704-T01-IM5 2803863 2660613 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51781835 COSM174732 133207258 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 29316426 surgery-fixed primary 71 ENSP00000415559.1:p.Glu114Lys ENST00000455089.5:c.340G>A 7:g.55143404G>A EGFR ENST00000275493.6 3633 3236 2675071 2675071 2534346 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 29110836 surgery-fixed NS 65 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451159 1451159 1375302 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451162 1451162 1375305 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1317182 1317182 1228083 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20126411 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EXTERN_MELA_20140514_008 2839310 2695076 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV104577177 COSM9365746 133279135 c.1861C>T p.L621F Substitution - Missense 38 7:55173059-55173059 + - PATHOGENIC .98429 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000415559.1:p.Leu621Phe ENST00000455089.5:c.1861C>T 7:g.55173059C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000400-T01-IM3 2715204 2574025 urinary_tract urethra NS NS carcinoma adenocarcinoma NS NS n COSV51859563 COSM6910210 132549516 c.2374G>A p.D792N Substitution - Missense het 38 7:55191758-55191758 + - PATHOGENIC .98912 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Asp792Asn ENST00000454757.6:c.2374G>A 7:g.55191758G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-B0-4822-01 2120426 1994662 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51848907 COSM3366976 132568355 c.841T>C p.C281R Substitution - Missense 38 7:55155916-55155916 + - PATHOGENIC .98755 Confirmed somatic variant 416 NS NS 78 ENSP00000395243.3:p.Cys281Arg ENST00000454757.6:c.841T>C 7:g.55155916T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-HT-8104-01 2194218 2062496 central_nervous_system brain NS NS glioma NS NS NS y COSV51788393 COSM13979 132563273 c.2035G>A p.G679S Substitution - Missense 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 545 NS NS 51 ENSP00000395243.3:p.Gly679Ser ENST00000454757.6:c.2035G>A 7:g.55174029G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 23 2699404 2558308 skin NS NS NS malignant_melanoma NS NS NS n COSV51774288 COSM6906389 133216589 c.1121_1122delinsTT p.A374V Substitution - Missense het 38 7:55157711-55157712 + - Confirmed somatic variant 29420467 surgery-fixed NS ENSP00000415559.1:p.Ala374Val ENST00000455089.5:c.1121_1122delinsTT 7:g.55157711_55157712delinsTT EGFR ENST00000275493.6 3633 3236 TCGA-FS-A1Z0-06 2121749 1995985 skin NS NS NS malignant_melanoma NS NS NS y COSV99293884 COSM7977358 99430840 c.3592C>A p.L1198I Substitution - Missense 38 7:55205576-55205576 + - PATHOGENIC .87661 Confirmed somatic variant 540 NS NS 32 ENSP00000275493.2:p.Leu1198Ile ENST00000275493.6:c.3592C>A 7:g.55205576C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AA-3811-01 1651034 1565821 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 376 NS NS 84 ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0154 2107952 1985813 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-56-8304-01 2385872 2248704 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99294789 COSM8694245 132570759 c.259G>T p.G87C Substitution - Missense 38 7:55143323-55143323 + - PATHOGENIC .99526 Confirmed somatic variant 418 NS primary 73 ENSP00000395243.3:p.Gly87Cys ENST00000454757.6:c.259G>T 7:g.55143323G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-19-1789-01 2178219 2046517 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51850088 COSM2156010 133228282 c.865C>T p.R289C Substitution - Missense 38 7:55155940-55155940 + - PATHOGENIC .91604 Confirmed somatic variant 329 NS NS 69 ENSP00000415559.1:p.Arg289Cys ENST00000455089.5:c.865C>T 7:g.55155940C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 95504 1973048 1859292 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSV51812284 COSM1651737 133250712 c.686C>T p.T229M Substitution - Missense 38 7:55154084-55154084 + - PATHOGENIC .92031 Confirmed somatic variant 23680147 surgery - NOS primary ENSP00000415559.1:p.Thr229Met ENST00000455089.5:c.686C>T 7:g.55154084C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-VS098-T1 2869935 2724932 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110457 COSM9807780 133233397 c.1030C>T p.P344S Substitution - Missense 38 7:55156790-55156790 + - PATHOGENIC .99297 Confirmed somatic variant 26950094 surgery - NOS NS 84 ENSP00000415559.1:p.Pro344Ser ENST00000455089.5:c.1030C>T 7:g.55156790C>T EGFR ENST00000275493.6 3633 3236 2115523 2115523 1989767 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2591421 2591421 2452381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1139402 1139402 1051966 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 18317075 surgery - NOS primary 63 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 82 2605253 2466144 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 25376516 surgery - NOS NS 68 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TG77905 2823147 2679001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 28818608 surgery-fixed NS 74 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1170509 1170509 1082643 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 19117057 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1317184 1317184 1228085 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20126411 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 945814 945814 862340 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 16144918 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 TCGA-19-1789-01 2178219 2046517 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51850088 COSM2156010 99402616 c.1000C>T p.R334C Substitution - Missense 38 7:55155940-55155940 + - PATHOGENIC .91604 Confirmed somatic variant 329 NS NS 69 ENSP00000275493.2:p.Arg334Cys ENST00000275493.6:c.1000C>T 7:g.55155940C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003016-T01-IM3 2719225 2578046 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51839629 COSM6925694 133239571 c.389C>T p.T130I Substitution - Missense het 38 7:55143453-55143453 + - NEUTRAL .47678 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr130Ile ENST00000455089.5:c.389C>T 7:g.55143453C>T EGFR ENST00000275493.6 3633 3236 WGC003608 2785119 2645235 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS y COSV99286188 COSM7420903 99435316 c.1570G>T p.V524F Substitution - Missense 38 7:55161570-55161570 + - .6767 Confirmed somatic variant 25526346 surgery fresh/frozen primary 54 ENSP00000275493.2:p.Val524Phe ENST00000275493.6:c.1570G>T 7:g.55161570G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1487000 1487000 1410618 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51807094 COSM20893 133221314 c.2387G>A p.R796K Substitution - Missense 38 7:55191771-55191771 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 58 ENSP00000415559.1:p.Arg796Lys ENST00000455089.5:c.2387G>A 7:g.55191771G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008849-T01-IM5 2724881 2583702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51786456 COSM6954013 133238799 c.2129C>G p.A710G Substitution - Missense het 38 7:55174801-55174801 + - PATHOGENIC .99346 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala710Gly ENST00000455089.5:c.2129C>G 7:g.55174801C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DU-5852-01 2194247 2062525 central_nervous_system brain NS NS glioma NS NS NS y COSV51787357 COSM3929123 132558981 c.2806A>T p.I936F Substitution - Missense 38 7:55200408-55200408 + - PATHOGENIC .9931 Confirmed somatic variant 545 NS NS 61 ENSP00000395243.3:p.Ile936Phe ENST00000454757.6:c.2806A>T 7:g.55200408A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000918-T01-IM3 2716255 2575076 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51799159 COSM747427 133228317 c.1631C>T p.P544L Substitution - Missense het 38 7:55165323-55165323 + - PATHOGENIC .95834 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Pro544Leu ENST00000455089.5:c.1631C>T 7:g.55165323C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920109 920109 837188 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51862985 COSM13431 133277464 c.2402A>G p.K801R Substitution - Missense het 38 7:55191786-55191786 + - PATHOGENIC .97673 Confirmed somatic variant 15623594 surgery-fixed NS 60 ENSP00000415559.1:p.Lys801Arg ENST00000455089.5:c.2402A>G 7:g.55191786A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876606 2876606 2731121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105111204 COSM9926231 132619277 c.2245C>T p.P749S Substitution - Missense 38 7:55181389-55181389 + - PATHOGENIC .97194 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000395243.3:p.Pro749Ser ENST00000454757.6:c.2245C>T 7:g.55181389C>T EGFR ENST00000275493.6 3633 3236 2876630 2876630 2731145 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51795112 COSM23633 99405507 c.2276T>A p.I759N Substitution - Missense 38 7:55174813-55174813 + - PATHOGENIC .99182 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000275493.2:p.Ile759Asn ENST00000275493.6:c.2276T>A 7:g.55174813T>A EGFR ENST00000275493.6 3633 3236 P-0000922-T01-IM3 2716264 2575085 skin NS NS NS malignant_melanoma NS NS NS n COSV51862272 COSM6913539 99439452 c.2702G>A p.G901E Substitution - Missense het 38 7:55198717-55198717 + - PATHOGENIC .99414 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Gly901Glu ENST00000275493.6:c.2702G>A 7:g.55198717G>A EGFR ENST00000275493.6 3633 3236 1170516 1170516 1082650 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 19117057 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1002744 1002744 919961 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense hom + - Confirmed somatic variant 16115929 surgery-fixed NS 49 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920037 920037 837116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 15623594 surgery fresh/frozen NS 76 ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 2150405 2150405 2019474 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 53 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591345 2591345 2452305 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 TCGA-DU-A5TY-01 2194202 2062480 central_nervous_system brain NS NS glioma NS NS NS y COSV51765897 COSM3929120 99438541 c.961G>T p.D321Y Substitution - Missense 38 7:55155901-55155901 + - PATHOGENIC .95198 Confirmed somatic variant 545 NS NS 46 ENSP00000275493.2:p.Asp321Tyr ENST00000275493.6:c.961G>T 7:g.55155901G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010499-T01-IM5 2726216 2585037 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS n COSV51832348 COSM6974705 132584044 c.3467C>T p.A1156V Substitution - Missense het 38 7:55205586-55205586 + - PATHOGENIC .8173 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala1156Val ENST00000454757.6:c.3467C>T 7:g.55205586C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003572-T01-IM5 2720057 2578878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 119 2218448 2086459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM1169667 178383005 c.? p.C620Y Substitution - Missense + - Confirmed somatic variant 25078279 surgery fresh/frozen recurrent 70 ENSP00000275493.2:p.Cys620Tyr EGFR ENST00000275493.6 3633 3236 TCGA-CN-4742-01 2193489 2061767 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825459 COSM122789 99385632 c.1423A>G p.I475V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Confirmed somatic variant 627 NS NS 48 ENSP00000275493.2:p.Ile475Val ENST00000275493.6:c.1423A>G 7:g.55160263A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Sample_1 2367134 2229992 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51788393 COSM13979 132563273 c.2035G>A p.G679S Substitution - Missense hom 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 24894453 NS NS ENSP00000395243.3:p.Gly679Ser ENST00000454757.6:c.2035G>A 7:g.55174029G>A EGFR ENST00000275493.6 3633 3236 982869 982869 898588 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1322264 1322264 1233151 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19844187 surgery-fixed primary 52 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489247 1489247 1412405 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876602 2876602 2731117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 57 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A065-T-S22 2757404 2616000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0012076-T01-IM5 2727219 2586040 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD7044a 1504255 1427133 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51826432 COSM4384121 133242153 c.1435G>A p.V479I Substitution - Missense 38 7:55161570-55161570 + - PATHOGENIC .78109 Confirmed somatic variant 24030381 NS NS ENSP00000415559.1:p.Val479Ile ENST00000455089.5:c.1435G>A 7:g.55161570G>A EGFR ENST00000275493.6 3633 3236 P-0002403-T01-IM3 2718680 2577501 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920020 920020 837099 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 72 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458687 1458687 1382662 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460155 1460155 1384032 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 3595 915982 833381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982867 982867 898586 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006876-T01-IM5 2723256 2582077 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BT-A42E-01 2193275 2061553 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51814701 COSM7084541 132549335 c.361G>T p.V121F Substitution - Missense 38 7:55143425-55143425 + - PATHOGENIC .99041 Confirmed somatic variant 413 NS NS 74 ENSP00000395243.3:p.Val121Phe ENST00000454757.6:c.361G>T 7:g.55143425G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 896925 896925 814548 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51771864 COSM6226 133211629 c.2191C>T p.R731C Substitution - Missense 38 7:55181335-55181335 + - PATHOGENIC .97187 Confirmed somatic variant 15329413 surgery-fixed NS ENSP00000415559.1:p.Arg731Cys ENST00000455089.5:c.2191C>T 7:g.55181335C>T EGFR ENST00000275493.6 3633 3236 17747 1423850 1333878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-NB016-T1 2869816 2724813 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV51776967 COSM6963220 132562155 c.1795C>T p.P599S Substitution - Missense 38 7:55172993-55172993 + - PATHOGENIC .96242 Confirmed somatic variant 26950094 surgery fresh/frozen NS 74 ENSP00000395243.3:p.Pro599Ser ENST00000454757.6:c.1795C>T 7:g.55172993C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD42098a 2894843 2749331 skin trunk NS NS malignant_melanoma nodular NS NS y COSV51776967 COSM6963220 132562155 c.1795C>T p.P599S Substitution - Missense 38 7:55172993-55172993 + - PATHOGENIC .96242 Confirmed somatic variant 33024263 surgery-fixed metastasis 42 ENSP00000395243.3:p.Pro599Ser ENST00000454757.6:c.1795C>T 7:g.55172993C>T EGFR ENST00000275493.6 3633 3236 1468092 1468092 1391938 peritoneum NS NS NS mesothelioma NS NS NS n COSV51816047 COSM53101 99387539 c.2192G>T p.W731L Substitution - Missense het 38 7:55174729-55174729 + - PATHOGENIC .99891 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000275493.2:p.Trp731Leu ENST00000275493.6:c.2192G>T 7:g.55174729G>T EGFR ENST00000275493.6 3633 3236 896925 896925 814548 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51771864 COSM6226 99383011 c.2326C>T p.R776C Substitution - Missense 38 7:55181335-55181335 + - PATHOGENIC .97187 Confirmed somatic variant 15329413 surgery-fixed NS ENSP00000275493.2:p.Arg776Cys ENST00000275493.6:c.2326C>T 7:g.55181335C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005094-T01-IM5 2721497 2580318 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 zcc203 2873641 2728634 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS y COSV99297135 COSM9212199 132566217 c.730G>T p.A244S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 33020650 surgery fresh/frozen NS ENSP00000395243.3:p.Ala244Ser ENST00000454757.6:c.730G>T 7:g.55154128G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003572-T01-IM5 2720057 2578878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009451-T01-IM5 2725378 2584199 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002265-T02-IM5 2719496 2578317 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 2591417 2591417 2452377 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451163 1451163 1375306 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1472951 1472951 1396650 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51853450 COSM53290 132553338 c.2480A>G p.E827G Substitution - Missense 38 7:55191864-55191864 + - PATHOGENIC .986 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000395243.3:p.Glu827Gly ENST00000454757.6:c.2480A>G 7:g.55191864A>G EGFR ENST00000275493.6 3633 3236 A014-T-S44 2758138 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152798 2152798 2021808 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458682 1458682 1382657 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489246 1489246 1412404 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1790518 1790518 1693497 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2811960 2811960 2668496 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed NS 78 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1004979 1004979 922191 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982863 982863 898582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1460135 1460135 1384012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1004991 1004991 922203 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876058 2876058 2730573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 56 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LC_C35 1863716 1754607 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0001707-T01-IM3 2717834 2576655 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1044284 1044284 960625 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 17321325 surgery fresh/frozen primary 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A014-T-S39 2758137 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011107-T01-IM5 2726736 2585557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 MSU3-c 2809980 2666642 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV99292326 COSM9176305 99406722 c.1579C>T p.R527W Substitution - Missense 38 7:55161579-55161579 + - NEUTRAL .28879 Confirmed somatic variant 26336987 surgery fresh/frozen primary 51 ENSP00000275493.2:p.Arg527Trp ENST00000275493.6:c.1579C>T 7:g.55161579C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-15-0742-01 1338018 1248403 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51827490 COSM39163 133223244 c.1772G>A p.C591Y Substitution - Missense 38 7:55171201-55171201 + - PATHOGENIC .98251 Confirmed somatic variant 329 surgery fresh/frozen NS 65 ENSP00000415559.1:p.Cys591Tyr ENST00000455089.5:c.1772G>A 7:g.55171201G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 17747 1423850 1333878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 SJHGG023_D 2307355 2172559 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 24705251 surgery - NOS NS 4 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 5-VS034-T2 2869859 2724856 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51802355 COSM6941144 99376606 c.1154C>T p.P385L Substitution - Missense 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 26950094 surgery - NOS NS 75 ENSP00000275493.2:p.Pro385Leu ENST00000275493.6:c.1154C>T 7:g.55156779C>T EGFR ENST00000275493.6 3633 3236 2876602 2876602 2731117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 57 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 S_TBL200_R7 2757771 2616345 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29106415 autopsy - NOS metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876058 2876058 2730573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 56 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876593 2876593 2731108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1091701 1091701 1006523 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26134 178388659 c.? p.P691S Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS ENSP00000275493.2:p.Pro691Ser EGFR ENST00000275493.6 3633 3236 P-0003572-T01-IM5 2720057 2578878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 TCGA-DU-7292-01 2194421 2062699 central_nervous_system brain NS NS glioma NS NS NS y COSV51800797 COSM3412178 99385042 c.755G>C p.R252P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 545 NS NS 69 ENSP00000275493.2:p.Arg252Pro ENST00000275493.6:c.755G>C 7:g.55154018G>C EGFR ENST00000275493.6 3633 3236 TCGA-B0-4822-01 2120426 1994662 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51848907 COSM3366976 99400150 c.976T>C p.C326R Substitution - Missense 38 7:55155916-55155916 + - PATHOGENIC .98755 Confirmed somatic variant 416 NS NS 78 ENSP00000275493.2:p.Cys326Arg ENST00000275493.6:c.976T>C 7:g.55155916T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-KT-A7W1-01 2262770 2129754 central_nervous_system brain NS NS glioma NS NS NS y COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 545 NS primary 45 ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CTS25 2393067 2255898 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 25189529 surgery fresh/frozen NS 67 ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DK-A3WW-01 2193226 2061504 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51790783 COSM3778506 133227399 c.3100G>A p.E1034K Substitution - Missense 38 7:55202589-55202589 + - PATHOGENIC .973 Confirmed somatic variant 413 NS NS 57 ENSP00000415559.1:p.Glu1034Lys ENST00000455089.5:c.3100G>A 7:g.55202589G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-CJ-4868-01 2120501 1994737 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51791922 COSM3366979 133237031 c.2377C>A p.L793M Substitution - Missense 38 7:55191761-55191761 + - PATHOGENIC .88511 Confirmed somatic variant 416 NS NS 42 ENSP00000415559.1:p.Leu793Met ENST00000455089.5:c.2377C>A 7:g.55191761C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812807 2812807 2669221 liver NS NS NS other adenoma NS NS n COSV51845994 COSM5530405 133202750 c.1498G>A p.E500K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 31189995 surgery-fixed NS 9 ENSP00000415559.1:p.Glu500Lys ENST00000455089.5:c.1498G>A 7:g.55163734G>A EGFR ENST00000275493.6 3633 3236 TCGA-QH-A6XC-01 2263268 2130252 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS primary 48 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 P-0003456-T01-IM5 2719933 2578754 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CHG-12-12649T 2634294 2494690 liver NS NS NS other neoplasm NS NS y COSV51767687 COSM6191352 133202248 c.1612G>A p.A538T Substitution - Missense 38 7:55165304-55165304 + - PATHOGENIC .98656 Confirmed somatic variant 660 NS primary 50 ENSP00000415559.1:p.Ala538Thr ENST00000455089.5:c.1612G>A 7:g.55165304G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1502212 1502212 1425091 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21457545 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 127 898383 815995 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0006846-T01-IM5 2723226 2582047 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489240 1489240 1412398 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 65 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000352-T01-IM3 2715098 2573919 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982852 982852 898571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920034 920034 837113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A062-T-S19 2757398 2615999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1109742 1109742 1023652 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 54 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004986 1004986 922198 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812083 2812083 2668551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 133206440 c.2113G>C p.A705P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Confirmed somatic variant 31534501 circulating tumour NS 68 ENSP00000415559.1:p.Ala705Pro ENST00000455089.5:c.2113G>C 7:g.55174785G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-76-4927-01 2120379 1994615 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 58 ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BK0016 2237570 2105074 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51768262 COSM26445 133205089 c.2165C>T p.A722V Substitution - Missense 38 7:55181309-55181309 + - PATHOGENIC .97799 Confirmed somatic variant 24504440 surgery - NOS NS ENSP00000415559.1:p.Ala722Val ENST00000455089.5:c.2165C>T 7:g.55181309C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 R074-I1 2813495 2669887 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99297135 COSM9212199 132566217 c.730G>T p.A244S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 28263318 surgery fresh/frozen NS 41 ENSP00000395243.3:p.Ala244Ser ENST00000454757.6:c.730G>T 7:g.55154128G>T EGFR ENST00000275493.6 3633 3236 920037 920037 837116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 15623594 surgery fresh/frozen NS 76 ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 P-0011553-T01-IM5 2727125 2585946 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51843499 COSM6981763 99402337 c.3321T>G p.N1107K Substitution - Missense het 38 7:55205305-55205305 + - PATHOGENIC .83021 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Asn1107Lys ENST00000275493.6:c.3321T>G 7:g.55205305T>G EGFR ENST00000275493.6 3633 3236 1179552 1179552 1091514 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18985444 surgery - NOS primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 896925 896925 814548 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15329413 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206767 1206767 1118645 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982881 982881 898600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1004981 1004981 922193 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1001256 1001256 918479 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920029 920029 837108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 40 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1001247 1001247 918470 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0005114-T01-IM5 2721517 2580338 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1109718 1109718 1023628 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 88 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982774 982774 898493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876602 2876602 2731117 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 57 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S_TBL200_R7 2757771 2616345 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29106415 autopsy - NOS metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 S003577 1027697 944673 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 99374883 c.1787C>T p.P596L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Pro596Leu ENST00000275493.6:c.1787C>T 7:g.55165344C>T EGFR ENST00000275493.6 3633 3236 TCGA-GN-A266-06 2121796 1996032 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 99401924 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 540 NS NS 45 ENSP00000275493.2:p.His47Tyr ENST00000275493.6:c.139C>T 7:g.55142336C>T EGFR ENST00000275493.6 3633 3236 2591345 2591345 2452305 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM3718342 178387182 c.? p.S752F Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Ser752Phe EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM12 2144553 2013767 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 24285547 surgery fresh/frozen primary 64 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 T197 2658249 2518408 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51792018 COSM4992972 99378183 c.3134C>T p.S1045F Substitution - Missense 38 7:55201754-55201754 + - PATHOGENIC .97067 Confirmed somatic variant 27149842 NS NS 67.58 ENSP00000275493.2:p.Ser1045Phe ENST00000275493.6:c.3134C>T 7:g.55201754C>T EGFR ENST00000275493.6 3633 3236 CRC177post 2730751 2589520 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51776247 COSM6110417 99392696 c.1393G>A p.G465R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Confirmed somatic variant 26416732 xenograft metastasis 59 ENSP00000275493.2:p.Gly465Arg ENST00000275493.6:c.1393G>A 7:g.55160233G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-0211-01 1910206 1798497 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 99378725 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 fresh/frozen - NOS primary 48 ENSP00000275493.2:p.Thr263Pro ENST00000275493.6:c.787A>C 7:g.55154050A>C EGFR ENST00000275493.6 3633 3236 1595807 1595807 1516604 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51841095 COSM133588 99399494 c.2270A>G p.K757R Substitution - Missense hom 38 7:55174807-55174807 + - PATHOGENIC .9946 Confirmed somatic variant 16551849 surgery-fixed NS 66 ENSP00000275493.2:p.Lys757Arg ENST00000275493.6:c.2270A>G 7:g.55174807A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000573-T01-IM3 2715544 2574365 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51795632 COSM26509 132565559 c.2092G>A p.A698T Substitution - Missense het 38 7:55174764-55174764 + - PATHOGENIC .99624 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ala698Thr ENST00000454757.6:c.2092G>A 7:g.55174764G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1505360 1505360 1428238 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51802570 COSM87245 132584186 c.2096T>C p.I699T Substitution - Missense 38 7:55174768-55174768 + - PATHOGENIC .99336 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000395243.3:p.Ile699Thr ENST00000454757.6:c.2096T>C 7:g.55174768T>C EGFR ENST00000275493.6 3633 3236 1091715 1091715 1006537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM26142 178386157 c.? p.G857E Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS ENSP00000275493.2:p.Gly857Glu EGFR ENST00000275493.6 3633 3236 5-VS098-T1 2869935 2724932 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110457 COSM9807780 99406853 c.1165C>T p.P389S Substitution - Missense 38 7:55156790-55156790 + - PATHOGENIC .99297 Confirmed somatic variant 26950094 surgery - NOS NS 84 ENSP00000275493.2:p.Pro389Ser ENST00000275493.6:c.1165C>T 7:g.55156790C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0012360-T01-IM5 2727428 2586249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 132550822 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Arg108Lys ENST00000454757.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006846-T01-IM5 2723226 2582047 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51781750 COSM6954369 133227541 c.819G>A p.M273I Substitution - Missense het 38 7:55155894-55155894 + - PATHOGENIC .91367 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Met273Ile ENST00000455089.5:c.819G>A 7:g.55155894G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1004985 1004985 922197 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011308-T01-IM5 2726911 2585732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A102-T-S04 2757412 2616002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 73 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0012083-T01-IM5 2727225 2586046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DU-5852-01 2194247 2062525 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 132553689 c.619C>T p.R207C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS NS 61 ENSP00000395243.3:p.Arg207Cys ENST00000454757.6:c.619C>T 7:g.55154017C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-E1-A7YJ-01 2457421 2320258 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 132553689 c.619C>T p.R207C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS primary 55 ENSP00000395243.3:p.Arg207Cys ENST00000454757.6:c.619C>T 7:g.55154017C>T EGFR ENST00000275493.6 3633 3236 YUOTHO 2439352 2302193 skin NS NS NS malignant_melanoma NS NS NS y COSV51848994 COSM5407724 99389532 c.1701G>A p.M567I Substitution - Missense het 38 7:55163802-55163802 + - PATHOGENIC .89204 Confirmed somatic variant 26214590 fresh/frozen - NOS primary 87 ENSP00000275493.2:p.Met567Ile ENST00000275493.6:c.1701G>A 7:g.55163802G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S001102 1027688 944664 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 133206822 c.652A>C p.T218P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Thr218Pro ENST00000455089.5:c.652A>C 7:g.55154050A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1595809 1595809 1516606 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 16551849 surgery-fixed NS 61 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011553-T01-IM5 2727125 2585946 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51843499 COSM6981763 132570338 c.3186T>G p.N1062K Substitution - Missense het 38 7:55205305-55205305 + - PATHOGENIC .83021 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Asn1062Lys ENST00000454757.6:c.3186T>G 7:g.55205305T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000316-T01-IM3 2715020 2573841 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792237 COSM6842523 132558035 c.694_695delinsGA p.M232E Substitution - Missense het 38 7:55154092-55154093 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Met232Glu ENST00000454757.6:c.694_695delinsGA 7:g.55154092_55154093delinsGA EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CC28 2766422 2624641 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV99034446 COSM7342224 133239638 c.2286C>A p.D762E Substitution - Missense 38 7:55181430-55181430 + - PATHOGENIC .94178 Confirmed somatic variant 29844865 surgery fresh/frozen NS 56 ENSP00000415559.1:p.Asp762Glu ENST00000455089.5:c.2286C>A 7:g.55181430C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002200-T01-IM3 2718492 2577313 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS n COSV51837290 COSM6921325 132566177 c.3200A>G p.N1067S Substitution - Missense het 38 7:55205319-55205319 + - PATHOGENIC .95172 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Asn1067Ser ENST00000454757.6:c.3200A>G 7:g.55205319A>G EGFR ENST00000275493.6 3633 3236 P-0005913-T01-IM5 2722296 2581117 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS n COSV51859214 COSM6946886 99376632 c.3596G>C p.R1199T Substitution - Missense het 38 7:55205580-55205580 + - PATHOGENIC .9752 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Arg1199Thr ENST00000275493.6:c.3596G>C 7:g.55205580G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876593 2876593 2731108 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 61 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876058 2876058 2730573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour recurrent 56 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460139 1460139 1384016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790305 COSM13194 132551901 c.2405C>T p.T802I Substitution - Missense 38 7:55191789-55191789 + - PATHOGENIC .95119 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000395243.3:p.Thr802Ile ENST00000454757.6:c.2405C>T 7:g.55191789C>T EGFR ENST00000275493.6 3633 3236 1054311 1054311 970382 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 17409862 surgery - NOS primary 49 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206716 1206716 1118594 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CTS25 2393067 2255898 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471562 1471562 1395301 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471540 1471540 1395279 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A014-T-S35 2758136 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A102-T-S33 2757414 2616002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008442-T01-IM5 2724559 2583380 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003551-T01-IM5 2720036 2578857 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460095 1460095 1383972 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1074387 1074387 989641 bone fibula NS NS osteosarcoma NS NS NS n COSV51796850 COSM24846 133241496 c.2356C>T p.R786C Substitution - Missense het 38 7:55191740-55191740 + - PATHOGENIC .9406 Confirmed somatic variant 17509661 fixed - NOS NS 44 ENSP00000415559.1:p.Arg786Cys ENST00000455089.5:c.2356C>T 7:g.55191740C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-EB-A431-01 2121600 1995836 skin NS NS NS malignant_melanoma NS NS NS y COSV51820698 COSM3639725 132572896 c.545C>T p.S182F Substitution - Missense 38 7:55152597-55152597 + - NEUTRAL .18615 Confirmed somatic variant 540 NS NS 34 ENSP00000395243.3:p.Ser182Phe ENST00000454757.6:c.545C>T 7:g.55152597C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S04-45633-TP 2366567 2229450 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51801932 COSM4992971 132586514 c.2153C>T p.A718V Substitution - Missense het 38 7:55181297-55181297 + - PATHOGENIC .97799 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000395243.3:p.Ala718Val ENST00000454757.6:c.2153C>T 7:g.55181297C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2696517 2696517 2555421 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28201779 surgery fresh/frozen NS 60 ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982786 982786 898505 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767386 COSM18423 132564484 c.2365G>T p.V789L Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .9903 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Val789Leu ENST00000454757.6:c.2365G>T 7:g.55191749G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T1803 2658686 2518845 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51850996 COSM6652242 133219008 c.1057G>A p.V353I Substitution - Missense 38 7:55156817-55156817 + - PATHOGENIC .99161 Confirmed somatic variant 27149842 NS NS 63 ENSP00000415559.1:p.Val353Ile ENST00000455089.5:c.1057G>A 7:g.55156817G>A EGFR ENST00000275493.6 3633 3236 TCGA-76-4927-01 2120379 1994615 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 58 ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 ESCC_74 2479576 2342336 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51766168 COSM1716256 133206916 c.2093C>T p.A698V Substitution - Missense 38 7:55174765-55174765 + - PATHOGENIC .99382 Confirmed somatic variant 26873401 NS NS 61 ENSP00000415559.1:p.Ala698Val ENST00000455089.5:c.2093C>T 7:g.55174765C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-71-8520-01 2194759 2063037 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001248 1001248 918471 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1505378 1505378 1428252 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471559 1471559 1395298 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0007076-T03-IM5 2723450 2582271 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS n COSV51860919 COSM6961890 99459614 c.593G>A p.S198N Substitution - Missense het 38 7:55151327-55151327 + - PATHOGENIC .89951 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ser198Asn ENST00000275493.6:c.593G>A 7:g.55151327G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A014-T-S25 2758134 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 16913 1423755 1333783 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009957-T01-IM5 2725784 2584605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-A2-A4S3-01 2187874 2056152 breast NS NS NS carcinoma NS NS NS y COSV51810209 COSM3833026 133207600 c.806A>G p.D269G Substitution - Missense 38 7:55155881-55155881 + - PATHOGENIC .96368 Confirmed somatic variant 414 NS NS 59 ENSP00000415559.1:p.Asp269Gly ENST00000455089.5:c.806A>G 7:g.55155881A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876630 2876630 2731145 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51795112 COSM23633 133231506 c.2141T>A p.I714N Substitution - Missense 38 7:55174813-55174813 + - PATHOGENIC .99182 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000415559.1:p.Ile714Asn ENST00000455089.5:c.2141T>A 7:g.55174813T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152760 2152760 2021770 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51780730 COSM22940 133206317 c.2192G>A p.R731H Substitution - Missense 38 7:55181336-55181336 + - PATHOGENIC .981 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Arg731His ENST00000455089.5:c.2192G>A 7:g.55181336G>A EGFR ENST00000275493.6 3633 3236 920037 920037 837116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777782 COSM6227 99381636 c.2504A>T p.H835L Substitution - Missense het 38 7:55191753-55191753 + - PATHOGENIC .98607 Confirmed somatic variant 15623594 surgery fresh/frozen NS 76 ENSP00000275493.2:p.His835Leu ENST00000275493.6:c.2504A>T 7:g.55191753A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002450-T01-IM3 2718725 2577546 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51777313 COSM13006 132549065 c.2185G>A p.V729M Substitution - Missense het 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Val729Met ENST00000454757.6:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BF-A1PU-01 2262877 2129861 skin NS NS NS malignant_melanoma NS NS NS y COSV99285705 COSM7864762 132560884 c.2666C>A p.P889H Substitution - Missense 38 7:55198816-55198816 + - PATHOGENIC .98141 Confirmed somatic variant 540 NS primary 46 ENSP00000395243.3:p.Pro889His ENST00000454757.6:c.2666C>A 7:g.55198816C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914581 914581 832030 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense het 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 15788655 surgery fresh/frozen primary 72 ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982788 982788 898507 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-GN-A269-01 2121799 1996035 skin NS NS NS malignant_melanoma NS NS NS y COSV51823432 COSM3639727 133218057 c.566A>G p.N189S Substitution - Missense 38 7:55152618-55152618 + - PATHOGENIC .95999 Confirmed somatic variant 540 NS NS 70 ENSP00000415559.1:p.Asn189Ser ENST00000455089.5:c.566A>G 7:g.55152618A>G EGFR ENST00000275493.6 3633 3236 GBM_IV-19 2354288 2218446 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2812807 2812807 2669221 liver NS NS NS other adenoma NS NS n COSV51845994 COSM5530405 99374106 c.1633G>A p.E545K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 31189995 surgery-fixed NS 9 ENSP00000275493.2:p.Glu545Lys ENST00000275493.6:c.1633G>A 7:g.55163734G>A EGFR ENST00000275493.6 3633 3236 1091703 1091703 1006525 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM26135 178382880 c.? p.K860E Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 1471564 1471564 1395303 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 2812111 2812111 2668565 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 31534501 circulating tumour NS 73 ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 1472947 1472947 1396646 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51816076 COSM53287 99400367 c.2131G>A p.E711K Substitution - Missense 38 7:55173990-55173990 + - PATHOGENIC .97511 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000275493.2:p.Glu711Lys ENST00000275493.6:c.2131G>A 7:g.55173990G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001300-T01-IM3 2717020 2575841 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004812 1004812 922024 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16140420 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009661-T01-IM5 2725553 2584374 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004691-T01-IM5 2721092 2579913 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KD591 1004977 922189 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary 50 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A062-T-S31 2757401 2615999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471560 1471560 1395299 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2760843 2760843 2619352 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM23613 178378830 c.? p.G719D Substitution - Missense + - Confirmed somatic variant 29416795 surgery - NOS primary 57 ENSP00000275493.2:p.Gly719Asp EGFR ENST00000275493.6 3633 3236 P-0005094-T01-IM5 2721497 2580318 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007779-T01-IM5 2724014 2582835 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002085-T02-IM5 2719477 2578298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 NS metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211044 1211044 1122912 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 945536 945536 862171 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51788393 COSM13979 99391974 c.2170G>A p.G724S Substitution - Missense het 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 16166444 surgery-fixed primary 57 ENSP00000275493.2:p.Gly724Ser ENST00000275493.6:c.2170G>A 7:g.55174029G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CHG-98T 2634280 2494676 liver NS NS NS other neoplasm NS NS y COSV51850174 COSM6307834 133229305 c.350A>G p.Y117C Substitution - Missense 38 7:55143414-55143414 + - PATHOGENIC .98157 Confirmed somatic variant 660 NS primary 51 ENSP00000415559.1:p.Tyr117Cys ENST00000455089.5:c.350A>G 7:g.55143414A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 77 897189 814812 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51777782 COSM6227 132554599 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000395243.3:p.His790Leu ENST00000454757.6:c.2369A>T 7:g.55191753A>T EGFR ENST00000275493.6 3633 3236 TCGA-BF-A1PU-01 2262877 2129861 skin NS NS NS malignant_melanoma NS NS NS y COSV99285705 COSM7864762 99389091 c.2801C>A p.P934H Substitution - Missense 38 7:55198816-55198816 + - PATHOGENIC .98141 Confirmed somatic variant 540 NS primary 46 ENSP00000275493.2:p.Pro934His ENST00000275493.6:c.2801C>A 7:g.55198816C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0016773-T01-IM6 2830871 2686686 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV104577017 COSM9359622 133222655 c.608G>A p.C203Y Substitution - Missense 38 7:55152660-55152660 + - PATHOGENIC .99504 Confirmed somatic variant 30205045 surgery-fixed primary 77 ENSP00000415559.1:p.Cys203Tyr ENST00000455089.5:c.608G>A 7:g.55152660G>A EGFR ENST00000275493.6 3633 3236 TCGA-GN-A266-06 2121796 1996032 skin NS NS NS malignant_melanoma NS NS NS y COSV51830943 COSM3639753 99417416 c.2764G>A p.E922K Substitution - Missense 38 7:55198779-55198779 + - PATHOGENIC .98622 Confirmed somatic variant 540 NS NS 45 ENSP00000275493.2:p.Glu922Lys ENST00000275493.6:c.2764G>A 7:g.55198779G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0012402-T01-IM5 2727458 2586279 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51850996 COSM6652242 133219008 c.1057G>A p.V353I Substitution - Missense het 38 7:55156817-55156817 + - PATHOGENIC .99161 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Val353Ile ENST00000455089.5:c.1057G>A 7:g.55156817G>A EGFR ENST00000275493.6 3633 3236 T1154 2296082 2161685 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51814845 COSM4680396 99447476 c.1697C>T p.A566V Substitution - Missense 38 7:55163798-55163798 + - NEUTRAL .08918 Confirmed somatic variant 25344691 NS NS 68.33 ENSP00000275493.2:p.Ala566Val ENST00000275493.6:c.1697C>T 7:g.55163798C>T EGFR ENST00000275493.6 3633 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 99378201 c.910C>T p.H304Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000275493.2:p.His304Tyr ENST00000275493.6:c.910C>T 7:g.55155850C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 17739 1423845 1333873 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A001-T-S04 2757357 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0005511-T02-IM5 2721904 2580725 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51836402 COSM6944131 99396528 c.2354C>G p.T785S Substitution - Missense het 38 7:55181363-55181363 + - PATHOGENIC .951 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Thr785Ser ENST00000275493.6:c.2354C>G 7:g.55181363C>G EGFR ENST00000275493.6 3633 3236 P-0012043-T01-IM5 2727190 2586011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008257-T01-IM5 2724396 2583217 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766389 COSM43067 133230198 c.739G>T p.V247L Substitution - Missense het 38 7:55154137-55154137 + - PATHOGENIC .98997 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Val247Leu ENST00000455089.5:c.739G>T 7:g.55154137G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 D023M059 2788448 2645740 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSV51802272 COSM13425 133221191 c.2170G>A p.V724M Substitution - Missense 38 7:55181314-55181314 + - PATHOGENIC .98024 Confirmed somatic variant 28120820 surgery-fixed metastasis ENSP00000415559.1:p.Val724Met ENST00000455089.5:c.2170G>A 7:g.55181314G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0012043-T01-IM5 2727190 2586011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001224 1001224 918447 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0013010-T01-IM5 2803821 2660571 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51866279 COSM6926300 132551487 c.530G>A p.R177H Substitution - Missense het 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 29316426 surgery-fixed primary 64 ENSP00000395243.3:p.Arg177His ENST00000454757.6:c.530G>A 7:g.55152582G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876045 2876045 2730560 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105111126 COSM9862211 133232972 c.1888C>T p.R630W Substitution - Missense 38 7:55173086-55173086 + - PATHOGENIC .96778 Confirmed somatic variant 29506987 NS recurrent 52 ENSP00000415559.1:p.Arg630Trp ENST00000455089.5:c.1888C>T 7:g.55173086C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000352-T01-IM3 2715098 2573919 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 P-0002265-T02-IM5 2719496 2578317 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 P-0009451-T01-IM5 2725378 2584199 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 P-0003572-T01-IM5 2720057 2578878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A065-T-S26 2757405 2616000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876045 2876045 2730560 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 52 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458684 1458684 1382659 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 SJHGG023_D 2307355 2172559 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 24705251 surgery - NOS NS 4 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001442-T01-IM3 2717305 2576126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914586 914586 832035 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003079-T01-IM5 2719588 2578409 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 pfg068T 2309636 2174838 stomach NS NS NS carcinoma intestinal_adenocarcinoma NS NS y COSV51767379 COSM85894 132557468 c.2392G>A p.V798I Substitution - Missense het 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 24816253 surgery fresh/frozen NS 74 ENSP00000395243.3:p.Val798Ile ENST00000454757.6:c.2392G>A 7:g.55191776G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006402-T01-IM5 2722778 2581599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 132547172 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Gly674Ser ENST00000454757.6:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372112 2372112 2234905 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_III anaplastic NS n COSV51822289 COSM42977 133227861 c.315G>T p.Q105H Substitution - Missense 38 7:55143379-55143379 + - PATHOGENIC .90579 Confirmed somatic variant 25694352 surgery fresh/frozen NS 28 ENSP00000415559.1:p.Gln105His ENST00000455089.5:c.315G>T 7:g.55143379G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000918-T01-IM3 2716255 2575076 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2372112 2372112 2234905 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_III anaplastic NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 25694352 surgery fresh/frozen NS 28 ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR ENST00000275493.6 3633 3236 2876045 2876045 2730560 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105111126 COSM9862211 99406560 c.2023C>T p.R675W Substitution - Missense 38 7:55173086-55173086 + - PATHOGENIC .96778 Confirmed somatic variant 29506987 NS recurrent 52 ENSP00000275493.2:p.Arg675Trp ENST00000275493.6:c.2023C>T 7:g.55173086C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0650-01 2120258 1994494 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779524 COSM18425 132552477 c.2021G>A p.G674D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Confirmed somatic variant 329 NS NS 39 ENSP00000395243.3:p.Gly674Asp ENST00000454757.6:c.2021G>A 7:g.55174015G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM12 2144553 2013767 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 24285547 surgery fresh/frozen primary 64 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1468095 1468095 1391941 peritoneum NS NS NS mesothelioma NS NS NS n COSV51818388 COSM53104 133232583 c.2255G>A p.C752Y Substitution - Missense het 38 7:55181399-55181399 + - PATHOGENIC .98244 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000415559.1:p.Cys752Tyr ENST00000455089.5:c.2255G>A 7:g.55181399G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Pat_01_A 2492837 2355451 NS NS NS NS malignant_melanoma NS NS NS y COSV51817615 COSM5872885 133232635 c.2654G>A p.G885E Substitution - Missense 38 7:55198804-55198804 + - PATHOGENIC .99081 Confirmed somatic variant 24265153 surgery-fixed NS 45 ENSP00000415559.1:p.Gly885Glu ENST00000455089.5:c.2654G>A 7:g.55198804G>A EGFR ENST00000275493.6 3633 3236 2665870 2665870 2525578 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM6842529 178386715 c.? p.V592I Substitution - Missense + - Confirmed somatic variant 28979142 surgery - NOS NS ENSP00000275493.2:p.Val592Ile EGFR_ENST00000454757 ENST00000454757.6 3498 3236 17739 1423845 1333873 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 132548975 c.2362T>G p.L788V Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Leu788Val ENST00000454757.6:c.2362T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 T3265 2658621 2518780 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51815655 COSM6652276 99460075 c.913G>A p.G305S Substitution - Missense 38 7:55155853-55155853 + - PATHOGENIC .97718 Confirmed somatic variant 27149842 NS NS 74.91 ENSP00000275493.2:p.Gly305Ser ENST00000275493.6:c.913G>A 7:g.55155853G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0012043-T01-IM5 2727190 2586011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 P-0001442-T01-IM3 2717305 2576126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 99396060 c.2281G>T p.D761Y Substitution - Missense het 38 7:55174818-55174818 + - PATHOGENIC .99554 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000275493.2:p.Asp761Tyr ENST00000275493.6:c.2281G>T 7:g.55174818G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DD-A11B-01 2194657 2062935 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51826802 COSM4934162 132553346 c.3116A>G p.D1039G Substitution - Missense 38 7:55202605-55202605 + - PATHOGENIC .91743 Confirmed somatic variant 628 NS NS 73 ENSP00000395243.3:p.Asp1039Gly ENST00000454757.6:c.3116A>G 7:g.55202605A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836251 COSM6348839 132575736 c.1392G>T p.L464F Substitution - Missense 38 7:55161527-55161527 + - PATHOGENIC .8964 Confirmed somatic variant 660 NS primary 46 ENSP00000395243.3:p.Leu464Phe ENST00000454757.6:c.1392G>T 7:g.55161527G>T EGFR ENST00000275493.6 3633 3236 P-0006952-T01-IM5 2723330 2582151 skin NS NS NS malignant_melanoma NS NS NS n COSV51774288 COSM6906389 99388629 c.1256_1257delinsTT p.A419V Substitution - Missense het 38 7:55157711-55157712 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala419Val ENST00000275493.6:c.1256_1257delinsTT 7:g.55157711_55157712delinsTT EGFR ENST00000275493.6 3633 3236 P-0000352-T01-IM3 2715098 2573919 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 255 2218456 2086467 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_III anaplastic NS n COSM4169570 178386630 c.? p.Y117C Substitution - Missense + - Confirmed somatic variant 25078279 surgery fresh/frozen recurrent 31 ENSP00000275493.2:p.Tyr117Cys EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003702-T02-IM5 2829639 2685454 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51831642 COSM1496684 132560351 c.853G>A p.E285K Substitution - Missense 38 7:55155928-55155928 + - PATHOGENIC .94538 Confirmed somatic variant 30205045 surgery-fixed metastasis 50 ENSP00000395243.3:p.Glu285Lys ENST00000454757.6:c.853G>A 7:g.55155928G>A EGFR ENST00000275493.6 3633 3236 P-0010180-T01-IM5 2725979 2584800 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1483443 1483443 1407069 upper_aerodigestive_tract head_neck NS NS carcinoma NS NS NS n COSV51767379 COSM85894 132557468 c.2392G>A p.V798I Substitution - Missense het 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 21274259 surgery-fixed NS 72 ENSP00000395243.3:p.Val798Ile ENST00000454757.6:c.2392G>A 7:g.55191776G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1472947 1472947 1396646 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51816063 COSM53286 133246309 c.1963A>T p.N655Y Substitution - Missense 38 7:55173957-55173957 + - PATHOGENIC .98177 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000415559.1:p.Asn655Tyr ENST00000455089.5:c.1963A>T 7:g.55173957A>T EGFR ENST00000275493.6 3633 3236 2876666 2876666 2731181 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51789261 COSM12986 99390495 c.2429G>A p.G810D Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98244 Confirmed somatic variant 29506987 pleural effusion NS 64 ENSP00000275493.2:p.Gly810Asp ENST00000275493.6:c.2429G>A 7:g.55181438G>A EGFR ENST00000275493.6 3633 3236 P-0003079-T01-IM5 2719588 2578409 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-IQ-7630-01 2193638 2061916 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51792433 COSM6966446 132577379 c.1627G>A p.G543S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 627 NS NS 49 ENSP00000395243.3:p.Gly543Ser ENST00000454757.6:c.1627G>A 7:g.55165319G>A EGFR ENST00000275493.6 3633 3236 TCGA-HD-7832-01 2193665 2061943 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99286255 COSM8295362 99426724 c.2900A>C p.E967A Substitution - Missense 38 7:55200367-55200367 + - PATHOGENIC .99358 Confirmed somatic variant 627 NS NS 52 ENSP00000275493.2:p.Glu967Ala ENST00000275493.6:c.2900A>C 7:g.55200367A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-26-5139-01 2120327 1994563 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51856614 COSM3412172 132594149 c.533G>A p.C178Y Substitution - Missense 38 7:55152585-55152585 + - PATHOGENIC .99676 Confirmed somatic variant 329 NS NS 65 ENSP00000395243.3:p.Cys178Tyr ENST00000454757.6:c.533G>A 7:g.55152585G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008246-T02-IM5 2724392 2583213 skin NS NS NS malignant_melanoma NS NS NS n COSV51776967 COSM6963220 133218398 c.1795C>T p.P599S Substitution - Missense het 38 7:55172993-55172993 + - PATHOGENIC .96242 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Pro599Ser ENST00000455089.5:c.1795C>T 7:g.55172993C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 HUB-02-B2-075 2607140 2466852 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51804558 COSM6040422 132596177 c.2244G>T p.M748I Substitution - Missense 38 7:55181388-55181388 + - PATHOGENIC .98402 Confirmed somatic variant 670 organoid culture NS ENSP00000395243.3:p.Met748Ile ENST00000454757.6:c.2244G>T 7:g.55181388G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 133216269 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2254T>A 7:g.55181398T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51812540 COSM1451536 133222895 c.322A>G p.R108G Substitution - Missense 38 7:55143386-55143386 + - PATHOGENIC .72671 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000415559.1:p.Arg108Gly ENST00000455089.5:c.322A>G 7:g.55143386A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982774 982774 898493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51788343 COSM18441 133273681 c.2019_2020delinsTT p.G674C Substitution - Missense 38 7:55174013-55174014 + - Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2019_2020delinsTT 7:g.55174013_55174014delinsTT EGFR ENST00000275493.6 3633 3236 MTP6_T1 2875766 2730344 pancreas NS NS NS other dysplasia-in_situ_neoplasm NS NS y COSV51779524 COSM18425 99379336 c.2156G>A p.G719D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Confirmed somatic variant 32796935 surgery-fixed NS 65 ENSP00000275493.2:p.Gly719Asp ENST00000275493.6:c.2156G>A 7:g.55174015G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832145 COSM6493936 133233446 c.2254T>G p.C752G Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95801 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000415559.1:p.Cys752Gly ENST00000455089.5:c.2254T>G 7:g.55181398T>G EGFR ENST00000275493.6 3633 3236 T3174 2296192 2161795 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 99383629 c.1580G>A p.R527Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 25344691 NS NS 74.41 ENSP00000275493.2:p.Arg527Gln ENST00000275493.6:c.1580G>A 7:g.55161580G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-D3-A8GB-06 2262876 2129860 skin NS NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 133209492 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 540 NS NS 48 ENSP00000415559.1:p.Ser116Phe ENST00000455089.5:c.347C>T 7:g.55143411C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T407 2658314 2518473 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51776282 COSM1168015 132547141 c.2123C>T p.P708L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Confirmed somatic variant 27149842 NS NS 69.16 ENSP00000395243.3:p.Pro708Leu ENST00000454757.6:c.2123C>T 7:g.55174795C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876606 2876606 2731121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 132560202 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982782 982782 898501 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S_TBL200_R4 2757768 2616342 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29106415 autopsy - NOS metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003274-T01-IM5 2719770 2578591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011219-T01-IM5 2726835 2585656 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827895 COSM3412174 133207223 c.550A>T p.S184C Substitution - Missense het 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ser184Cys ENST00000455089.5:c.550A>T 7:g.55152602A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DUMC-18 2748715 2607418 central_nervous_system frontoparietal NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 29802247 surgery fresh/frozen NS 52 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 1472947 1472947 1396646 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51816063 COSM53286 99421632 c.2098A>T p.N700Y Substitution - Missense 38 7:55173957-55173957 + - PATHOGENIC .98177 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000275493.2:p.Asn700Tyr ENST00000275493.6:c.2098A>T 7:g.55173957A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2492700 2492700 2355315 skin face NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 132569945 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen primary ENSP00000395243.3:p.His47Tyr ENST00000454757.6:c.139C>T 7:g.55142336C>T EGFR ENST00000275493.6 3633 3236 TCGA-EE-A2GO-06 2121665 1995901 skin NS NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 99383908 c.3025G>A p.D1009N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 540 NS NS 66 ENSP00000275493.2:p.Asp1009Asn ENST00000275493.6:c.3025G>A 7:g.55201266G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-VS094-T1 2869927 2724924 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51776578 COSM4893368 132554177 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 26950094 surgery - NOS NS 84 ENSP00000395243.3:p.Ser116Phe ENST00000454757.6:c.347C>T 7:g.55143411C>T EGFR ENST00000275493.6 3633 3236 1595812 1595812 1516609 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51848710 COSM26438 99389356 c.2620G>A p.G874S Substitution - Missense het 38 7:55191869-55191869 + - PATHOGENIC .98912 Confirmed somatic variant 16551849 surgery-fixed NS 60 ENSP00000275493.2:p.Gly874Ser ENST00000275493.6:c.2620G>A 7:g.55191869G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51816377 COSM3412194 99374959 c.1786C>T p.P596S Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99531 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000275493.2:p.Pro596Ser ENST00000275493.6:c.1786C>T 7:g.55165343C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006402-T01-IM5 2722778 2581599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 132547357 c.1991A>C p.E664A Substitution - Missense het 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Glu664Ala ENST00000454757.6:c.1991A>C 7:g.55173985A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876067 2876067 2730582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A028-T-S06 2757394 2615998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 75 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001253 1001253 918476 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460152 1460152 1384029 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206719 1206719 1118597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876064 2876064 2730579 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001826-T01-IM3 2718069 2576890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206772 1206772 1118650 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152792 2152792 2021802 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 88 2630342 2490726 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51769145 COSM3266559 133241176 c.739G>A p.V247M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 27756406 surgery-fixed primary 48 ENSP00000415559.1:p.Val247Met ENST00000455089.5:c.739G>A 7:g.55154137G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006155-T02-IM5 2722533 2581354 skin NS NS NS malignant_melanoma NS NS NS n COSV51769325 COSM6950792 132592193 c.2948_2949delinsTG p.S983L Substitution - Missense het 38 7:55201324-55201325 + - Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Ser983Leu ENST00000454757.6:c.2948_2949delinsTG 7:g.55201324_55201325delinsTG EGFR ENST00000275493.6 3633 3236 P-0000918-T01-IM3 2716255 2575076 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51799159 COSM747427 99402636 c.1766C>T p.P589L Substitution - Missense het 38 7:55165323-55165323 + - PATHOGENIC .95834 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Pro589Leu ENST00000275493.6:c.1766C>T 7:g.55165323C>T EGFR ENST00000275493.6 3633 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836185 COSM4884832 99407985 c.739G>T p.D247Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 660 NS primary 46 ENSP00000275493.2:p.Asp247Tyr ENST00000275493.6:c.739G>T 7:g.55152656G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000583-T01-IM3 2715566 2574387 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 TCGA-DU-A5TY-01 2194202 2062480 central_nervous_system brain NS NS glioma NS NS NS y COSV51765881 COSM3929118 99438536 c.949G>A p.E317K Substitution - Missense 38 7:55155889-55155889 + - PATHOGENIC .99356 Confirmed somatic variant 545 NS NS 46 ENSP00000275493.2:p.Glu317Lys ENST00000275493.6:c.949G>A 7:g.55155889G>A EGFR ENST00000275493.6 3633 3236 P-0012043-T01-IM5 2727190 2586011 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 P-0011219-T01-IM5 2726835 2585656 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827895 COSM3412174 99379092 c.685A>T p.S229C Substitution - Missense het 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ser229Cys ENST00000275493.6:c.685A>T 7:g.55152602A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S003577 1027697 944673 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 133203297 c.1652C>T p.P551L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000415559.1:p.Pro551Leu ENST00000455089.5:c.1652C>T 7:g.55165344C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 KD534 1004976 922188 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458680 1458680 1382655 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AA-A00N-01 1651102 1565889 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51852585 COSM274945 132559389 c.791G>A p.R264Q Substitution - Missense 38 7:55155866-55155866 + - PATHOGENIC .98601 Confirmed somatic variant 22810696 376 NS NS 75 ENSP00000395243.3:p.Arg264Gln ENST00000454757.6:c.791G>A 7:g.55155866G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489241 1489241 1412399 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811937 2811937 2668488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion metastasis 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-DK-A3WW-01 2193226 2061504 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51790783 COSM3778506 99401840 c.3235G>A p.E1079K Substitution - Missense 38 7:55202589-55202589 + - PATHOGENIC .973 Confirmed somatic variant 413 NS NS 57 ENSP00000275493.2:p.Glu1079Lys ENST00000275493.6:c.3235G>A 7:g.55202589G>A EGFR ENST00000275493.6 3633 3236 P-0009449-T01-IM5 2725376 2584197 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003068-T01-IM5 2719577 2578398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51843270 COSM6926023 132570294 c.953C>A p.T318N Substitution - Missense het 38 7:55156614-55156614 + - PATHOGENIC .99429 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr318Asn ENST00000454757.6:c.953C>A 7:g.55156614C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010107-T01-IM5 2725918 2584739 genital_tract extragonadal soft_tissue NS germ_cell_tumour yolk_sac_tumour NS NS n COSV51834570 COSM6972645 132557826 c.1720C>A p.L574M Substitution - Missense het 38 7:55165412-55165412 + - PATHOGENIC .9982 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Leu574Met ENST00000454757.6:c.1720C>A 7:g.55165412C>A EGFR ENST00000275493.6 3633 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51812540 COSM1451536 99396971 c.322A>G p.R108G Substitution - Missense 38 7:55143386-55143386 + - PATHOGENIC .72671 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000275493.2:p.Arg108Gly ENST00000275493.6:c.322A>G 7:g.55143386A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GYWU_937 2771256 2629453 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV99290440 COSM7410173 133243622 c.3038G>A p.C1013Y Substitution - Missense 38 7:55202527-55202527 + - NEUTRAL .29295 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000415559.1:p.Cys1013Tyr ENST00000455089.5:c.3038G>A 7:g.55202527G>A EGFR ENST00000275493.6 3633 3236 TCGA-B0-4849-01 2120441 1994677 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51791922 COSM3366979 99410018 c.2512C>A p.L838M Substitution - Missense 38 7:55191761-55191761 + - PATHOGENIC .88511 Confirmed somatic variant 416 NS NS 51 ENSP00000275493.2:p.Leu838Met ENST00000275493.6:c.2512C>A 7:g.55191761C>A EGFR ENST00000275493.6 3633 3236 Au2 2466841 2329672 skin scalp NS NS malignant_melanoma desmoplastic NS NS y COSV51779748 COSM3639716 99401924 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26343386 surgery fresh/frozen NS 85 ENSP00000275493.2:p.His47Tyr ENST00000275493.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836185 COSM4884832 133234939 c.604G>T p.D202Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 660 NS primary 46 ENSP00000415559.1:p.Asp202Tyr ENST00000455089.5:c.604G>T 7:g.55152656G>T EGFR ENST00000275493.6 3633 3236 2665871 2665871 2525579 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM6842529 178386715 c.? p.V592I Substitution - Missense + - Confirmed somatic variant 28979142 surgery - NOS NS ENSP00000275493.2:p.Val592Ile EGFR_ENST00000454757 ENST00000454757.6 3498 3236 ILMN12 2816772 2673123 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV104369087 COSM9238851 132576562 c.1702G>A p.A568T Substitution - Missense 38 7:55165394-55165394 + - PATHOGENIC .87498 Confirmed somatic variant 29937994 surgery fresh/frozen NS 45 ENSP00000395243.3:p.Ala568Thr ENST00000454757.6:c.1702G>A 7:g.55165394G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004227-T01-IM5 2720634 2579455 pancreas NS NS NS carcinoma acinar_carcinoma NS NS n COSV51849414 COSM6934088 132592187 c.3406G>C p.A1136P Substitution - Missense het 38 7:55205525-55205525 + - PATHOGENIC .73179 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ala1136Pro ENST00000454757.6:c.3406G>C 7:g.55205525G>C EGFR ENST00000275493.6 3633 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876038 2876038 2730553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 60 898380 815992 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152776 2152776 2021786 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920024 920024 837103 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000370-T01-IM3 2715141 2573962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 A021-T-S23 2757383 2615995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 57 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152788 2152788 2021798 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152793 2152793 2021803 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206737 1206737 1118615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GYWU_937 2771256 2629453 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV99290440 COSM7410173 132582578 c.3038G>A p.C1013Y Substitution - Missense 38 7:55202527-55202527 + - NEUTRAL .29295 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000395243.3:p.Cys1013Tyr ENST00000454757.6:c.3038G>A 7:g.55202527G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_C1 1863682 1754573 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51772009 COSM26704 132553247 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 22975805 surgery fresh/frozen primary 54 ENSP00000395243.3:p.Leu702Ser ENST00000454757.6:c.2105T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 TCGA-FG-A87Q-01 2339613 2204596 central_nervous_system brain NS NS glioma NS NS NS y COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 545 NS primary 61 ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 TCGA-EB-A431-01 2121600 1995836 skin NS NS NS malignant_melanoma NS NS NS y COSV51820698 COSM3639725 99404973 c.680C>T p.S227F Substitution - Missense 38 7:55152597-55152597 + - NEUTRAL .18615 Confirmed somatic variant 540 NS NS 34 ENSP00000275493.2:p.Ser227Phe ENST00000275493.6:c.680C>T 7:g.55152597C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982778 982778 898497 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005435-T01-IM5 2721825 2580646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 P-0008849-T01-IM5 2724881 2583702 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51786456 COSM6954013 99412394 c.2264C>G p.A755G Substitution - Missense het 38 7:55174801-55174801 + - PATHOGENIC .99346 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala755Gly ENST00000275493.6:c.2264C>G 7:g.55174801C>G EGFR ENST00000275493.6 3633 3236 P-0004607-T02-IM5 2721004 2579825 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152789 2152789 2021799 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0003569-T01-IM5 2720054 2578875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152760 2152760 2021770 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1001224 1001224 918447 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005464-T01-IM5 2721855 2580676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2811942 2811942 2668490 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed NS 55 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876057 2876057 2730572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 56 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1790519 1790519 1693498 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 773 898394 816006 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 16784 1423726 1333754 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002861-T01-IM3 2719087 2577908 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876662 2876662 2731177 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 74 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-TQ-A7RP-01 2457441 2320278 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 132553689 c.619C>T p.R207C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS primary 66 ENSP00000395243.3:p.Arg207Cys ENST00000454757.6:c.619C>T 7:g.55154017C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T660 2296260 2161863 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51781835 COSM174732 132552286 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 25344691 NS NS 66.58 ENSP00000395243.3:p.Glu114Lys ENST00000454757.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914581 914581 832030 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792805 COSM13005 133203995 c.2183A>T p.H728L Substitution - Missense het 38 7:55181327-55181327 + - PATHOGENIC .98404 Confirmed somatic variant 15788655 surgery fresh/frozen primary 72 ENSP00000415559.1:p.His728Leu ENST00000455089.5:c.2183A>T 7:g.55181327A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594193 1594193 1515167 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51804843 COSM12429 132553900 c.2438_2439delinsGT p.L813R Substitution - Missense het 38 7:55191822-55191823 + - Confirmed somatic variant 19726454 surgery fresh/frozen primary 58 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438_2439delinsGT 7:g.55191822_55191823delinsGT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009449-T01-IM5 2725376 2584197 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982774 982774 898493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 RS40M 2653649 2513771 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 132547472 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS metastasis 41.32 ENSP00000395243.3:p.Arg476Lys ENST00000454757.6:c.1427G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 P-0010181-T01-IM5 2725980 2584801 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1468655 1468655 1392406 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-QH-A6XC-01 2263268 2130252 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS primary 48 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003456-T01-IM5 2719933 2578754 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 TCGA-D3-A8GB-06 2262876 2129860 skin NS NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 99381173 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 540 NS NS 48 ENSP00000275493.2:p.Ser116Phe ENST00000275493.6:c.347C>T 7:g.55143411C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005889-T01-IM5 2722273 2581094 testis NS NS NS germ_cell_tumour seminoma NS NS n COSV51857848 COSM6946731 133207903 c.1319G>A p.G440D Substitution - Missense het 38 7:55160294-55160294 + - NEUTRAL .16911 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Gly440Asp ENST00000455089.5:c.1319G>A 7:g.55160294G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0012358-T01-IM5 2727426 2586247 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51844677 COSM6984453 132568098 c.2864C>T p.A955V Substitution - Missense het 38 7:55201240-55201240 + - PATHOGENIC .95761 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Ala955Val ENST00000454757.6:c.2864C>T 7:g.55201240C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1468100 1468100 1391946 peritoneum NS NS NS mesothelioma NS NS NS n COSV51815934 COSM28607 132551460 c.2468A>G p.E823G Substitution - Missense het 38 7:55191852-55191852 + - PATHOGENIC .96745 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000395243.3:p.Glu823Gly ENST00000454757.6:c.2468A>G 7:g.55191852A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 LC_C12 1863693 1754584 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460139 1460139 1384016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152795 2152795 2021805 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206725 1206725 1118603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920031 920031 837110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 59 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0007236-T01-IM5 2723596 2582417 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 4163 915992 833391 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-KT-A7W1-01 2262770 2129754 central_nervous_system brain NS NS glioma NS NS NS y COSV51779524 COSM18425 132552477 c.2021G>A p.G674D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Confirmed somatic variant 545 NS primary 45 ENSP00000395243.3:p.Gly674Asp ENST00000454757.6:c.2021G>A 7:g.55174015G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1043243 1043243 959584 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51779524 COSM18425 132552477 c.2021G>A p.G674D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Confirmed somatic variant 17142003 surgery fresh/frozen primary ENSP00000395243.3:p.Gly674Asp ENST00000454757.6:c.2021G>A 7:g.55174015G>A EGFR ENST00000275493.6 3633 3236 CH-LA8 2211434 2079637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51855488 COSM4166393 99390906 c.710C>T p.A237V Substitution - Missense 38 7:55152627-55152627 + - PATHOGENIC .99229 Confirmed somatic variant 24449147 surgery fresh/frozen NS 67 ENSP00000275493.2:p.Ala237Val ENST00000275493.6:c.710C>T 7:g.55152627C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P121 2072581 1951936 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51785554 COSM21688 132548847 c.836G>T p.R279L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 57.59 ENSP00000395243.3:p.Arg279Leu ENST00000454757.6:c.836G>T 7:g.55155911G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 S02-14875-TP 2366560 2229443 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51780206 COSM12373 132553376 c.2024C>T p.S675F Substitution - Missense het 38 7:55174018-55174018 + - PATHOGENIC .9768 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000395243.3:p.Ser675Phe ENST00000454757.6:c.2024C>T 7:g.55174018C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 5-2A 2746100 2604803 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51847285 COSM7284415 132595743 c.2893G>A p.V965M Substitution - Missense 38 7:55201269-55201269 + - PATHOGENIC .72324 Confirmed somatic variant 646 NS primary 51 ENSP00000395243.3:p.Val965Met ENST00000454757.6:c.2893G>A 7:g.55201269G>A EGFR ENST00000275493.6 3633 3236 P-0009042-T01-IM5 2725031 2583852 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 99378340 c.2248G>C p.A750P Substitution - Missense het 38 7:55174785-55174785 + - PATHOGENIC .99356 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala750Pro ENST00000275493.6:c.2248G>C 7:g.55174785G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CH-LA8 2211434 2079637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51855488 COSM4166393 132562300 c.575C>T p.A192V Substitution - Missense 38 7:55152627-55152627 + - PATHOGENIC .99229 Confirmed somatic variant 24449147 surgery fresh/frozen NS 67 ENSP00000395243.3:p.Ala192Val ENST00000454757.6:c.575C>T 7:g.55152627C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0006924-T01-IM5 2723304 2582125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773712 COSM13433 132558066 c.2183A>G p.H728R Substitution - Missense het 38 7:55181327-55181327 + - PATHOGENIC .98391 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.His728Arg ENST00000454757.6:c.2183A>G 7:g.55181327A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-12-0616 2108021 1985882 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011293-T01-IM5 2726897 2585718 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51862653 COSM6980033 132547658 c.1665G>T p.M555I Substitution - Missense het 38 7:55165357-55165357 + - PATHOGENIC .94832 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Met555Ile ENST00000454757.6:c.1665G>T 7:g.55165357G>T EGFR ENST00000275493.6 3633 3236 1170514 1170514 1082648 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 19117057 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451164 1451164 1375307 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-76-4931-01 2120382 1994618 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 70 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DU-7013-01 2194399 2062677 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 59 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-HT-A5RC-01 2194260 2062538 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 70 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BC85-ctDNA 2668219 2527792 breast NS NS NS carcinoma NS NS NS y COSV51834499 COSM6845063 132548992 c.829G>A p.G277S Substitution - Missense het 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 27535334 circulating tumour metastasis ENSP00000395243.3:p.Gly277Ser ENST00000454757.6:c.829G>A 7:g.55155904G>A EGFR ENST00000275493.6 3633 3236 TCGA-VS-A9UA-01 2386196 2249028 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99290048 COSM8641365 99417880 c.528G>C p.M176I Substitution - Missense 38 7:55146709-55146709 + - NEUTRAL .34467 Confirmed somatic variant 415 NS primary 60 ENSP00000275493.2:p.Met176Ile ENST00000275493.6:c.528G>C 7:g.55146709G>C EGFR ENST00000275493.6 3633 3236 P-0003016-T01-IM3 2719225 2578046 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51839629 COSM6925694 99413294 c.389C>T p.T130I Substitution - Missense het 38 7:55143453-55143453 + - NEUTRAL .47678 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr130Ile ENST00000275493.6:c.389C>T 7:g.55143453C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006952-T01-IM5 2723330 2582151 skin NS NS NS malignant_melanoma NS NS NS n COSV51774288 COSM6906389 133216589 c.1121_1122delinsTT p.A374V Substitution - Missense het 38 7:55157711-55157712 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala374Val ENST00000455089.5:c.1121_1122delinsTT 7:g.55157711_55157712delinsTT EGFR ENST00000275493.6 3633 3236 TCGA-FG-A87Q-01 2339613 2204596 central_nervous_system brain NS NS glioma NS NS NS y COSV99289246 COSM8268187 99378347 c.788C>T p.T263I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 545 NS primary 61 ENSP00000275493.2:p.Thr263Ile ENST00000275493.6:c.788C>T 7:g.55154051C>T EGFR ENST00000275493.6 3633 3236 AH29 2906938 2761105 endometrium NS NS NS hyperplasia atypical NS NS y COSV51832348 COSM6974705 99420157 c.3602C>T p.A1201V Substitution - Missense 38 7:55205586-55205586 + - PATHOGENIC .8173 Confirmed somatic variant 33016334 surgery-fixed NS ENSP00000275493.2:p.Ala1201Val ENST00000275493.6:c.3602C>T 7:g.55205586C>T EGFR ENST00000275493.6 3633 3236 TCGA-GN-A269-01 2121799 1996035 skin NS NS NS malignant_melanoma NS NS NS y COSV51823432 COSM3639727 99390373 c.701A>G p.N234S Substitution - Missense 38 7:55152618-55152618 + - PATHOGENIC .95999 Confirmed somatic variant 540 NS NS 70 ENSP00000275493.2:p.Asn234Ser ENST00000275493.6:c.701A>G 7:g.55152618A>G EGFR ENST00000275493.6 3633 3236 P-0009239-T01-IM5 2725198 2584019 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51792469 COSM6967655 99401154 c.1607T>A p.V536E Substitution - Missense het 38 7:55161607-55161607 + - PATHOGENIC .99007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Val536Glu ENST00000275493.6:c.1607T>A 7:g.55161607T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1005022 1005022 922234 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766618 COSM12374 132551897 c.2447T>G p.L816R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000395243.3:p.Leu816Arg ENST00000454757.6:c.2447T>G 7:g.55191831T>G EGFR ENST00000275493.6 3633 3236 P-0003456-T01-IM5 2719933 2578754 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 99380629 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg252Cys ENST00000275493.6:c.754C>T 7:g.55154017C>T EGFR ENST00000275493.6 3633 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 99388191 c.2389T>A p.C797S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2389T>A 7:g.55181398T>A EGFR ENST00000275493.6 3633 3236 P-0012360-T01-IM5 2727428 2586249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 99377698 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg108Lys ENST00000275493.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001817-T02-IM5 2719456 2578277 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 NB-1204 1898491 1787175 autonomic_ganglia NS NS NS neuroblastoma NS NS NS y COSV51767481 COSM1284692 99385507 c.1922C>A p.P641H Substitution - Missense 38 7:55172985-55172985 + - PATHOGENIC .97992 Confirmed somatic variant 23334666 NS NS ENSP00000275493.2:p.Pro641His ENST00000275493.6:c.1922C>A 7:g.55172985C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CRC177post 2730751 2589520 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51776247 COSM6110417 133220044 c.1258G>A p.G420R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Confirmed somatic variant 26416732 xenograft metastasis 59 ENSP00000415559.1:p.Gly420Arg ENST00000455089.5:c.1258G>A 7:g.55160233G>A EGFR ENST00000275493.6 3633 3236 1002754 1002754 919971 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 16115929 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1451149 1451149 1375292 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2862278 2862278 2717468 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV105110411 COSM9581267 132551079 c.3302G>C p.C1101S Substitution - Missense 38 7:55205421-55205421 + - NEUTRAL .16376 Confirmed somatic variant 32578376 surgery fresh/frozen primary 69 ENSP00000395243.3:p.Cys1101Ser ENST00000454757.6:c.3302G>C 7:g.55205421G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CH-LA8 2211434 2079637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51855488 COSM4166393 133218567 c.575C>T p.A192V Substitution - Missense 38 7:55152627-55152627 + - PATHOGENIC .99229 Confirmed somatic variant 24449147 surgery fresh/frozen NS 67 ENSP00000415559.1:p.Ala192Val ENST00000455089.5:c.575C>T 7:g.55152627C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-TM-A7C3-01 2262979 2129963 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 43 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TARGET-30-PALUDH-01A-01W 2195523 2063801 autonomic_ganglia NS NS NS neuroblastoma NS NS NS y COSV51767481 COSM1284692 133213976 c.1787C>A p.P596H Substitution - Missense 38 7:55172985-55172985 + - PATHOGENIC .97992 Confirmed somatic variant 584 NS NS ENSP00000415559.1:p.Pro596His ENST00000455089.5:c.1787C>A 7:g.55172985C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MSU3-c 2809980 2666642 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV99292326 COSM9176305 133233205 c.1444C>T p.R482W Substitution - Missense 38 7:55161579-55161579 + - NEUTRAL .28879 Confirmed somatic variant 26336987 surgery fresh/frozen primary 51 ENSP00000415559.1:p.Arg482Trp ENST00000455089.5:c.1444C>T 7:g.55161579C>T EGFR ENST00000275493.6 3633 3236 P-0009451-T01-IM5 2725378 2584199 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51781835 COSM174732 99379122 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Glu114Lys ENST00000275493.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SC_9028 2467372 2330203 prostate NS NS NS carcinoma NS NS NS y COSV51850909 COSM5557485 133218719 c.2203A>G p.I735V Substitution - Missense het 38 7:55181347-55181347 + - PATHOGENIC .9793 Confirmed somatic variant 26000489 surgery - NOS metastasis 71 ENSP00000415559.1:p.Ile735Val ENST00000455089.5:c.2203A>G 7:g.55181347A>G EGFR ENST00000275493.6 3633 3236 2864405 2864405 2719563 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 31761448 circulating tumour recurrent 60 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1589268 1589268 1510422 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51809033 COSM133147 133213510 c.1997_1998inv p.E666V Substitution - Missense 38 7:55173991-55173992 + - Confirmed somatic variant 22026926 surgery fresh/frozen NS ENSP00000415559.1:p.Glu666Val ENST00000455089.5:c.1997_1998inv 7:g.55173991_55173992inv EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010765-T01-IM5 2726446 2585267 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010864-T01-IM5 2726533 2585354 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51864573 COSM6977465 133212428 c.982C>T p.P328S Substitution - Missense het 38 7:55156643-55156643 + - PATHOGENIC .91736 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Pro328Ser ENST00000455089.5:c.982C>T 7:g.55156643C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010345-T01-IM5 2726113 2584934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010181-T01-IM5 2725980 2584801 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T3174 2296192 2161795 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 133212226 c.1445G>A p.R482Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 25344691 NS NS 74.41 ENSP00000415559.1:p.Arg482Gln ENST00000455089.5:c.1445G>A 7:g.55161580G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006846-T01-IM5 2723226 2582047 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920037 920037 837116 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777782 COSM6227 133210005 c.2369A>T p.H790L Substitution - Missense het 38 7:55191753-55191753 + - PATHOGENIC .98607 Confirmed somatic variant 15623594 surgery fresh/frozen NS 76 ENSP00000415559.1:p.His790Leu ENST00000455089.5:c.2369A>T 7:g.55191753A>T EGFR ENST00000275493.6 3633 3236 P-0016773-T01-IM6 2830871 2686686 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV104577018 COSM9359626 99396642 c.3217C>A p.P1073T Substitution - Missense 38 7:55202571-55202571 + - PATHOGENIC .97286 Confirmed somatic variant 30205045 surgery-fixed primary 77 ENSP00000275493.2:p.Pro1073Thr ENST00000275493.6:c.3217C>A 7:g.55202571C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD42095c 2894834 2749322 skin extremity NS NS malignant_melanoma in_situ_melanotic_neoplasm NS NS y COSV51767260 COSM12988 132547166 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 33024263 surgery-fixed metastasis 56 ENSP00000395243.3:p.Glu664Lys ENST00000454757.6:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 982774 982774 898493 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51788343 COSM18441 99450460 c.2154_2155delinsTT p.G719C Substitution - Missense 38 7:55174013-55174014 + - Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2154_2155delinsTT 7:g.55174013_55174014delinsTT EGFR ENST00000275493.6 3633 3236 127 898383 815995 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489240 1489240 1412398 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 65 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1109742 1109742 1023652 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18372921 surgery-fixed primary 54 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1502212 1502212 1425091 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21457545 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A062-T-S19 2757398 2615999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920034 920034 837113 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982852 982852 898571 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0000352-T01-IM3 2715098 2573919 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836288 COSM6348843 99408048 c.2342G>T p.C781F Substitution - Missense 38 7:55181351-55181351 + - PATHOGENIC .98402 Confirmed somatic variant 660 NS primary 46 ENSP00000275493.2:p.Cys781Phe ENST00000275493.6:c.2342G>T 7:g.55181351G>T EGFR ENST00000275493.6 3633 3236 1004986 1004986 922198 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920031 920031 837110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51866622 COSM13426 132601484 c.2377C>G p.L793V Substitution - Missense het 38 7:55191761-55191761 + - PATHOGENIC .89306 Confirmed somatic variant 15623594 surgery fresh/frozen NS 59 ENSP00000395243.3:p.Leu793Val ENST00000454757.6:c.2377C>G 7:g.55191761C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1472947 1472947 1396646 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51816076 COSM53287 133225558 c.1996G>A p.E666K Substitution - Missense 38 7:55173990-55173990 + - PATHOGENIC .97511 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000415559.1:p.Glu666Lys ENST00000455089.5:c.1996G>A 7:g.55173990G>A EGFR ENST00000275493.6 3633 3236 T1803 2658686 2518845 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51850996 COSM6652242 99391393 c.1192G>A p.V398I Substitution - Missense 38 7:55156817-55156817 + - PATHOGENIC .99161 Confirmed somatic variant 27149842 NS NS 63 ENSP00000275493.2:p.Val398Ile ENST00000275493.6:c.1192G>A 7:g.55156817G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010267-T01-IM5 2726054 2584875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 17234 1423805 1333833 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458685 1458685 1382660 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982854 982854 898573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876655 2876655 2731170 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 70 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876666 2876666 2731181 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 pleural effusion NS 64 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206714 1206714 1118592 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489250 1489250 1412408 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004997 1004997 922209 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 198 898387 815999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458698 1458698 1382673 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0005889-T01-IM5 2722273 2581094 testis NS NS NS germ_cell_tumour seminoma NS NS n COSV51857848 COSM6946731 99379729 c.1454G>A p.G485D Substitution - Missense het 38 7:55160294-55160294 + - NEUTRAL .16911 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Gly485Asp ENST00000275493.6:c.1454G>A 7:g.55160294G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1690841 1690841 1599108 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 133216074 c.1339A>C p.S447R Substitution - Missense het 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 22270724 surgery - NOS recurrent 64 ENSP00000415559.1:p.Ser447Arg ENST00000455089.5:c.1339A>C 7:g.55160314A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004870 1007062 924270 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 16863509 NS NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010345-T01-IM5 2726113 2584934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1010436 1010436 927610 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 17001163 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002085-T02-IM5 2719477 2578298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767827 COSM1235378 133226447 c.2425A>T p.T809S Substitution - Missense het 38 7:55191809-55191809 + - PATHOGENIC .98595 Confirmed somatic variant 28481359 NS metastasis ENSP00000415559.1:p.Thr809Ser ENST00000455089.5:c.2425A>T 7:g.55191809A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005553-T01-IM5 2721946 2580767 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876042 2876042 2730557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 43 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2812102 2812102 2668561 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 pleural effusion NS 58 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 S_TBL200_R6 2757770 2616344 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29106415 autopsy - NOS metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1486993 1486993 1410611 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51789362 COSM13184 132574086 c.2101G>A p.E701K Substitution - Missense 38 7:55174773-55174773 + - PATHOGENIC .99624 Confirmed somatic variant 16567021 surgery-fixed primary 44 ENSP00000395243.3:p.Glu701Lys ENST00000454757.6:c.2101G>A 7:g.55174773G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2872355 2872355 2727352 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS n COSV105864558 COSM9946366 132605273 c.3466G>A p.A1156T Substitution - Missense 38 7:55205585-55205585 + - PATHOGENIC .85295 Confirmed somatic variant 31648313 blood-bone marrow recurrent 2.5 ENSP00000395243.3:p.Ala1156Thr ENST00000454757.6:c.3466G>A 7:g.55205585G>A EGFR ENST00000275493.6 3633 3236 TCGA-DD-AAE3-01 2339647 2204630 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51766284 COSM28512 99377567 c.2230A>G p.I744V Substitution - Missense 38 7:55174767-55174767 + - PATHOGENIC .99591 Confirmed somatic variant 628 NS primary 50 ENSP00000275493.2:p.Ile744Val ENST00000275493.6:c.2230A>G 7:g.55174767A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1486987 1486987 1410605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777202 COSM20896 132585150 c.2365G>A p.V789M Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 58 ENSP00000395243.3:p.Val789Met ENST00000454757.6:c.2365G>A 7:g.55191749G>A EGFR ENST00000275493.6 3633 3236 P-0003169-T01-IM5 2719662 2578483 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 P-0000316-T01-IM3 2715020 2573841 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792237 COSM6842523 99385661 c.829_830delinsGA p.M277E Substitution - Missense het 38 7:55154092-55154093 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Met277Glu ENST00000275493.6:c.829_830delinsGA 7:g.55154092_55154093delinsGA EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-DU-8158-01 2194237 2062515 central_nervous_system brain NS NS glioma NS NS NS y COSV51771223 COSM3929114 132554477 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 545 NS NS 57 ENSP00000395243.3:p.Glu84Val ENST00000454757.6:c.251A>T 7:g.55143315A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-BR-A4QL-01 2197931 2066209 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51771306 COSM1318972 132562649 c.1778C>T p.T593M Substitution - Missense 38 7:55171207-55171207 + - NEUTRAL .03249 Confirmed somatic variant 541 NS NS 75 ENSP00000395243.3:p.Thr593Met ENST00000454757.6:c.1778C>T 7:g.55171207C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920041 920041 837120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 132552328 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 15623594 surgery fresh/frozen NS 75 ENSP00000395243.3:p.Ser723Ile ENST00000454757.6:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 P-0012402-T01-IM5 2727458 2586279 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51850996 COSM6652242 99391393 c.1192G>A p.V398I Substitution - Missense het 38 7:55156817-55156817 + - PATHOGENIC .99161 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Val398Ile ENST00000275493.6:c.1192G>A 7:g.55156817G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD6883a 1504094 1426972 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia NS n COSV51850592 COSM4384117 133213492 c.619C>G p.R207G Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .93941 Confirmed somatic variant 24030381 NS NS ENSP00000415559.1:p.Arg207Gly ENST00000455089.5:c.619C>G 7:g.55154017C>G EGFR ENST00000275493.6 3633 3236 TCGA-76-4931-01 2120382 1994618 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 70 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 TCGA-DU-7013-01 2194399 2062677 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 59 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 TCGA-HT-A5RC-01 2194260 2062538 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 70 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-C5-A1BM-01 2193409 2061687 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51807983 COSM4826463 133257283 c.2297C>G p.S766C Substitution - Missense 38 7:55181441-55181441 + - PATHOGENIC .97792 Confirmed somatic variant 415 NS NS 78 ENSP00000415559.1:p.Ser766Cys ENST00000455089.5:c.2297C>G 7:g.55181441C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0011503-T01-IM5 2727075 2585896 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 132564457 c.1658G>C p.G553A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly553Ala ENST00000454757.6:c.1658G>C 7:g.55165350G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DU-A5TY-01 2194202 2062480 central_nervous_system brain NS NS glioma NS NS NS y COSV51765897 COSM3929120 133261415 c.826G>T p.D276Y Substitution - Missense 38 7:55155901-55155901 + - PATHOGENIC .95198 Confirmed somatic variant 545 NS NS 46 ENSP00000415559.1:p.Asp276Tyr ENST00000455089.5:c.826G>T 7:g.55155901G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1468094 1468094 1391940 peritoneum NS NS NS mesothelioma NS NS NS n COSV51772198 COSM53103 133231452 c.2218A>G p.T740A Substitution - Missense het 38 7:55181362-55181362 + - PATHOGENIC .94016 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000415559.1:p.Thr740Ala ENST00000455089.5:c.2218A>G 7:g.55181362A>G EGFR ENST00000275493.6 3633 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0003551-T01-IM5 2720036 2578857 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0008442-T01-IM5 2724559 2583380 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A102-T-S33 2757414 2616002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CTS25 2393067 2255898 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206716 1206716 1118594 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009661-T01-IM5 2725553 2584374 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 A014-T-S35 2758136 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471540 1471540 1395279 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471562 1471562 1395301 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1460095 1460095 1383972 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 YUMER 2013650 1896282 skin NS NS NS malignant_melanoma NS NS NS y COSV51841339 COSM1698695 132552751 c.1879C>T p.H627Y Substitution - Missense het 38 7:55173077-55173077 + - PATHOGENIC .95363 Confirmed somatic variant 22842228 NS NS ENSP00000395243.3:p.His627Tyr ENST00000454757.6:c.1879C>T 7:g.55173077C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001442-T01-IM3 2717305 2576126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772923 COSM21984 133222251 c.2146G>T p.D716Y Substitution - Missense het 38 7:55174818-55174818 + - PATHOGENIC .99554 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000415559.1:p.Asp716Tyr ENST00000455089.5:c.2146G>T 7:g.55174818G>T EGFR ENST00000275493.6 3633 3236 P-0009948-T02-IM5 2725775 2584596 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 255 2218456 2086467 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_III anaplastic NS n COSM34166 178380439 c.? p.R108K Substitution - Missense + - Confirmed somatic variant 25078279 surgery fresh/frozen recurrent 31 ENSP00000275493.2:p.Arg108Lys EGFR ENST00000275493.6 3633 3236 P-0010345-T01-IM5 2726113 2584934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982788 982788 898507 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766331 COSM12366 132582479 c.2437C>A p.L813M Substitution - Missense 38 7:55191821-55191821 + - PATHOGENIC .93782 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Met ENST00000454757.6:c.2437C>A 7:g.55191821C>A EGFR ENST00000275493.6 3633 3236 1004870 1007062 924270 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 16863509 NS NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 ESCC_61 2479566 2342326 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51828987 COSM5632947 99379165 c.2141A>C p.K714T Substitution - Missense 38 7:55174000-55174000 + - PATHOGENIC .9691 Confirmed somatic variant 26873401 NS NS 53 ENSP00000275493.2:p.Lys714Thr ENST00000275493.6:c.2141A>C 7:g.55174000A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-E1-A7YD-01 2386254 2249086 central_nervous_system brain NS NS glioma NS NS NS y COSV51785554 COSM21688 133203816 c.836G>T p.R279L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 545 NS primary 57 ENSP00000415559.1:p.Arg279Leu ENST00000455089.5:c.836G>T 7:g.55155911G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM_IV-19 2354288 2218446 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 TCGA-CD-A4MG-01 2198123 2066401 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51852047 COSM3881818 99393989 c.1289C>T p.T430I Substitution - Missense 38 7:55157744-55157744 + - PATHOGENIC .99429 Confirmed somatic variant 541 NS NS 76 ENSP00000275493.2:p.Thr430Ile ENST00000275493.6:c.1289C>T 7:g.55157744C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SJHGG023_D 2307355 2172559 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 24705251 surgery - NOS NS 4 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 GYWU_937 2771256 2629453 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV99290440 COSM7410173 99418403 c.3173G>A p.C1058Y Substitution - Missense 38 7:55202527-55202527 + - NEUTRAL .29295 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000275493.2:p.Cys1058Tyr ENST00000275493.6:c.3173G>A 7:g.55202527G>A EGFR ENST00000275493.6 3633 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 PC-9BRc1 2015227 1897435 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 23733853 cell-line NS ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0005763-T01-IM5 2722150 2580971 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2812111 2812111 2668565 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 circulating tumour NS 73 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-MV-A51V-01 2193279 2061557 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51815409 COSM7143473 99390764 c.1169A>G p.Q390R Substitution - Missense 38 7:55156794-55156794 + - NEUTRAL .3199 Confirmed somatic variant 413 NS NS 75 ENSP00000275493.2:p.Gln390Arg ENST00000275493.6:c.1169A>G 7:g.55156794A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 17747 1423850 1333878 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 P-0002085-T02-IM5 2719477 2578298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767827 COSM1235378 99401095 c.2560A>T p.T854S Substitution - Missense het 38 7:55191809-55191809 + - PATHOGENIC .98595 Confirmed somatic variant 28481359 NS metastasis ENSP00000275493.2:p.Thr854Ser ENST00000275493.6:c.2560A>T 7:g.55191809A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-71-8520-01 2194759 2063037 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 417 NS NS 60 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876649 2876649 2731164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105111022 COSM9869939 132618255 c.2140A>C p.I714L Substitution - Missense 38 7:55174812-55174812 + - PATHOGENIC .99492 Confirmed somatic variant 29506987 circulating tumour NS 48 ENSP00000395243.3:p.Ile714Leu ENST00000454757.6:c.2140A>C 7:g.55174812A>C EGFR ENST00000275493.6 3633 3236 TCGA-56-8304-01 2385872 2248704 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99294789 COSM8694245 99402749 c.259G>T p.G87C Substitution - Missense 38 7:55143323-55143323 + - PATHOGENIC .99526 Confirmed somatic variant 418 NS primary 73 ENSP00000275493.2:p.Gly87Cys ENST00000275493.6:c.259G>T 7:g.55143323G>T EGFR ENST00000275493.6 3633 3236 TCGA-DD-A1EK-01 2194557 2062835 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51801820 COSM4934357 99435065 c.3448A>T p.T1150S Substitution - Missense 38 7:55205432-55205432 + - NEUTRAL .25214 Confirmed somatic variant 628 NS NS 64 ENSP00000275493.2:p.Thr1150Ser ENST00000275493.6:c.3448A>T 7:g.55205432A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GB052T 2634017 2494413 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 132547806 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 672 NS primary ENSP00000395243.3:p.Arg177Cys ENST00000454757.6:c.529C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003456-T01-IM5 2719933 2578754 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 133208833 c.619C>T p.R207C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg207Cys ENST00000455089.5:c.619C>T 7:g.55154017C>T EGFR ENST00000275493.6 3633 3236 TCGA-28-1745-01 2178166 2046464 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99288542 COSM7459054 99419228 c.3032T>A p.V1011E Substitution - Missense 38 7:55201273-55201273 + - PATHOGENIC .99252 Confirmed somatic variant 329 NS NS 76 ENSP00000275493.2:p.Val1011Glu ENST00000275493.6:c.3032T>A 7:g.55201273T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 DUMC-22 2748718 2607421 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51771223 COSM3929114 132554477 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 29802247 surgery fresh/frozen NS 62 ENSP00000395243.3:p.Glu84Val ENST00000454757.6:c.251A>T 7:g.55143315A>T EGFR ENST00000275493.6 3633 3236 587220 1766747 1671067 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51792177 COSM1205050 99381154 c.1279C>T p.R427C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 22895193 surgery fresh/frozen primary ENSP00000275493.2:p.Arg427Cys ENST00000275493.6:c.1279C>T 7:g.55157734C>T EGFR ENST00000275493.6 3633 3236 SJHYPO052-D 2590140 2451270 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 99381154 c.1279C>T p.R427C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 23334668 blood-bone marrow NS 16.3 ENSP00000275493.2:p.Arg427Cys ENST00000275493.6:c.1279C>T 7:g.55157734C>T EGFR ENST00000275493.6 3633 3236 TCGA-E1-A7YD-01 2386254 2249086 central_nervous_system brain NS NS glioma NS NS NS y COSV51785554 COSM21688 99375522 c.971G>T p.R324L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 545 NS primary 57 ENSP00000275493.2:p.Arg324Leu ENST00000275493.6:c.971G>T 7:g.55155911G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 R074-I1 2813495 2669887 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 41 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T197 2658249 2518408 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51792018 COSM4992972 133206283 c.2999C>T p.S1000F Substitution - Missense 38 7:55201754-55201754 + - PATHOGENIC .97067 Confirmed somatic variant 27149842 NS NS 67.58 ENSP00000415559.1:p.Ser1000Phe ENST00000455089.5:c.2999C>T 7:g.55201754C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FG-A87Q-01 2339613 2204596 central_nervous_system brain NS NS glioma NS NS NS y COSV99289246 COSM8268187 133206444 c.653C>T p.T218I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 545 NS primary 61 ENSP00000415559.1:p.Thr218Ile ENST00000455089.5:c.653C>T 7:g.55154051C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876606 2876606 2731121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2156364 2156364 2025373 lung right_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 24752053 surgery - NOS primary 48 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1194723 1194723 1106618 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51853292 COSM29339 133255054 c.271A>C p.I91L Substitution - Missense 38 7:55143335-55143335 + - PATHOGENIC .99037 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000415559.1:p.Ile91Leu ENST00000455089.5:c.271A>C 7:g.55143335A>C EGFR ENST00000275493.6 3633 3236 P-0012358-T01-IM5 2727426 2586247 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51844677 COSM6984453 99399892 c.2999C>T p.A1000V Substitution - Missense het 38 7:55201240-55201240 + - PATHOGENIC .95761 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ala1000Val ENST00000275493.6:c.2999C>T 7:g.55201240C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-GN-A266-06 2121796 1996032 skin NS NS NS malignant_melanoma NS NS NS y COSV51830943 COSM3639753 133242786 c.2629G>A p.E877K Substitution - Missense 38 7:55198779-55198779 + - PATHOGENIC .98622 Confirmed somatic variant 540 NS NS 45 ENSP00000415559.1:p.Glu877Lys ENST00000455089.5:c.2629G>A 7:g.55198779G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-26-5139-01 2120327 1994563 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51840469 COSM2157152 132594161 c.1748G>T p.C583F Substitution - Missense 38 7:55171177-55171177 + - PATHOGENIC .98352 Confirmed somatic variant 329 NS NS 65 ENSP00000395243.3:p.Cys583Phe ENST00000454757.6:c.1748G>T 7:g.55171177G>T EGFR ENST00000275493.6 3633 3236 S001102 1027688 944664 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 99378725 c.787A>C p.T263P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000275493.2:p.Thr263Pro ENST00000275493.6:c.787A>C 7:g.55154050A>C EGFR ENST00000275493.6 3633 3236 1468094 1468094 1391940 peritoneum NS NS NS mesothelioma NS NS NS n COSV51772198 COSM53103 99405468 c.2353A>G p.T785A Substitution - Missense het 38 7:55181362-55181362 + - PATHOGENIC .94016 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000275493.2:p.Thr785Ala ENST00000275493.6:c.2353A>G 7:g.55181362A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920041 920041 837120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 132547597 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15623594 surgery fresh/frozen NS 75 ENSP00000395243.3:p.Gly674Cys ENST00000454757.6:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 2591475 2591475 2452435 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-MV-A51V-01 2193279 2061557 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51815409 COSM7143473 133218448 c.1034A>G p.Q345R Substitution - Missense 38 7:55156794-55156794 + - NEUTRAL .3199 Confirmed somatic variant 413 NS NS 75 ENSP00000415559.1:p.Gln345Arg ENST00000455089.5:c.1034A>G 7:g.55156794A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CHC892T 2340454 2205437 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51854735 COSM4794914 132579459 c.3007G>A p.A1003T Substitution - Missense 38 7:55201762-55201762 + - NEUTRAL .20234 Confirmed somatic variant 381 NS primary 72 ENSP00000395243.3:p.Ala1003Thr ENST00000454757.6:c.3007G>A 7:g.55201762G>A EGFR ENST00000275493.6 3633 3236 P-0000400-T01-IM3 2715204 2574025 urinary_tract urethra NS NS carcinoma adenocarcinoma NS NS n COSV51859563 COSM6910210 99376263 c.2509G>A p.D837N Substitution - Missense het 38 7:55191758-55191758 + - PATHOGENIC .98912 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Asp837Asn ENST00000275493.6:c.2509G>A 7:g.55191758G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1468097 1468097 1391943 peritoneum NS NS NS mesothelioma NS NS NS n COSV51801471 COSM53105 132553118 c.2357G>A p.R786H Substitution - Missense het 38 7:55191741-55191741 + - PATHOGENIC .96289 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000395243.3:p.Arg786His ENST00000454757.6:c.2357G>A 7:g.55191741G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CHG-13-09220T 2634310 2494706 liver NS NS NS other neoplasm NS NS y COSV51802176 COSM6258054 132617514 c.111G>T p.K37N Substitution - Missense 38 7:55142308-55142308 + - PATHOGENIC .84286 Confirmed somatic variant 660 NS primary 67 ENSP00000395243.3:p.Lys37Asn ENST00000454757.6:c.111G>T 7:g.55142308G>T EGFR ENST00000275493.6 3633 3236 1468093 1468093 1391939 peritoneum NS NS NS mesothelioma NS NS NS n COSV51847876 COSM53102 99448637 c.2200G>C p.E734Q Substitution - Missense het 38 7:55174737-55174737 + - PATHOGENIC .99895 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000275493.2:p.Glu734Gln ENST00000275493.6:c.2200G>C 7:g.55174737G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S_TBL200_R6 2757770 2616344 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29106415 autopsy - NOS metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152782 2152782 2021792 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 911963 911963 829455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15780185 NS NS 50 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0012079-T01-IM5 2727221 2586042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 4991 915993 833392 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 860 898395 816007 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007076-T03-IM5 2723450 2582271 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS n COSV51860919 COSM6961890 133284109 c.458G>A p.S153N Substitution - Missense het 38 7:55151327-55151327 + - PATHOGENIC .89951 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ser153Asn ENST00000455089.5:c.458G>A 7:g.55151327G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010053-T01-IM5 2725865 2584686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 132549293 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu816Gln ENST00000454757.6:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152755 2152755 2021765 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766268 COSM13183 132550670 c.2090T>C p.V697A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Val697Ala ENST00000454757.6:c.2090T>C 7:g.55174762T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0004666-T01-IM5 2721066 2579887 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 132559938 c.1339A>C p.S447R Substitution - Missense het 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Ser447Arg ENST00000454757.6:c.1339A>C 7:g.55160314A>C EGFR ENST00000275493.6 3633 3236 P-0008757-T01-IM5 2724807 2583628 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000686-T01-IM3 2715784 2574605 skin NS NS NS malignant_melanoma NS NS NS n COSV51781503 COSM5608352 132568875 c.1774C>T p.P592S Substitution - Missense het 38 7:55171203-55171203 + - NEUTRAL .1586 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Pro592Ser ENST00000454757.6:c.1774C>T 7:g.55171203C>T EGFR ENST00000275493.6 3633 3236 KD591 1004977 922189 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary 50 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471560 1471560 1395299 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1211044 1211044 1122912 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0007779-T01-IM5 2724014 2582835 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 T1244 2658449 2518608 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 99383629 c.1580G>A p.R527Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 62.75 ENSP00000275493.2:p.Arg527Gln ENST00000275493.6:c.1580G>A 7:g.55161580G>A EGFR ENST00000275493.6 3633 3236 1004812 1004812 922024 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16140420 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0001300-T01-IM3 2717020 2575841 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0004691-T01-IM5 2721092 2579913 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0009661-T01-IM5 2725553 2584374 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0002085-T02-IM5 2719477 2578298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 NS metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A062-T-S31 2757401 2615999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982778 982778 898497 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51798694 COSM18419 132613501 c.2065G>A p.E689K Substitution - Missense 38 7:55174737-55174737 + - PATHOGENIC .99879 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Glu689Lys ENST00000454757.6:c.2065G>A 7:g.55174737G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0001826-T01-IM3 2718069 2576890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1468632 1468632 1392383 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468649 1468649 1392400 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1498496 1498496 1421374 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21040950 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004523-T01-IM5 2829761 2685576 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51780877 COSM26717 133203719 c.2444A>T p.K815I Substitution - Missense 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 30205045 surgery-fixed metastasis 58 ENSP00000415559.1:p.Lys815Ile ENST00000455089.5:c.2444A>T 7:g.55191828A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002964-T02-IM3 2719172 2577993 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51843252 COSM6925373 133252392 c.2887G>T p.D963Y Substitution - Missense het 38 7:55201263-55201263 + - PATHOGENIC .98531 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Asp963Tyr ENST00000455089.5:c.2887G>T 7:g.55201263G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003311-T01-IM5 2719805 2578626 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51794846 COSM6927745 132592742 c.3182A>T p.Q1061L Substitution - Missense het 38 7:55205301-55205301 + - PATHOGENIC .70456 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gln1061Leu ENST00000454757.6:c.3182A>T 7:g.55205301A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471543 1471543 1395282 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1790520 1790520 1693499 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1458693 1458693 1382668 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1471533 1471533 1395272 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PM02T 2653317 2513444 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS primary 75.8 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CTS149 2393053 2255884 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 66 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 982882 982882 898601 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876603 2876603 2731118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 60 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-AA-3811-01 1651034 1565821 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51779162 COSM21689 132548259 c.1652C>T p.P551L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 376 NS NS 84 ENSP00000395243.3:p.Pro551Leu ENST00000454757.6:c.1652C>T 7:g.55165344C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-14-1827-01 2178235 2046533 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99295901 COSM7467664 132593735 c.368C>T p.S123F Substitution - Missense 38 7:55143432-55143432 + - PATHOGENIC .82087 Confirmed somatic variant 329 NS NS 51 ENSP00000395243.3:p.Ser123Phe ENST00000454757.6:c.368C>T 7:g.55143432C>T EGFR ENST00000275493.6 3633 3236 P-0002491-T01-IM3 2718763 2577584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0002085-T02-IM5 2719477 2578298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 NS metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006115-T01-IM5 2722495 2581316 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51836136 COSM5574310 133222649 c.2764G>A p.E922K Substitution - Missense het 38 7:55200366-55200366 + - PATHOGENIC .99379 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Glu922Lys ENST00000455089.5:c.2764G>A 7:g.55200366G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SJALL043850-R 2824118 2679946 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV51836136 COSM5574310 133222649 c.2764G>A p.E922K Substitution - Missense 38 7:55200366-55200366 + - PATHOGENIC .99379 Confirmed somatic variant 31697823 blood-bone marrow recurrent 12.84 ENSP00000415559.1:p.Glu922Lys ENST00000455089.5:c.2764G>A 7:g.55200366G>A EGFR ENST00000275493.6 3633 3236 914586 914586 832035 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A065-T-S26 2757405 2616000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458684 1458684 1382659 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0001442-T01-IM3 2717305 2576126 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876045 2876045 2730560 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 52 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 17234 1423805 1333833 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 zcc203 2873641 2728634 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 33020650 surgery fresh/frozen NS ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-KT-A7W1-01 2262770 2129754 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 45 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206722 1206722 1118600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002524-T01-IM3 2718790 2577611 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A014-T-S30 2758135 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CTS177 2393057 2255888 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876063 2876063 2730578 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-55-8506-01 2194766 2063044 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 62 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51808387 COSM3412196 133220832 c.1658G>C p.G553A Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000415559.1:p.Gly553Ala ENST00000455089.5:c.1658G>C 7:g.55165350G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0237 2107974 1985835 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 23917401 NS NS ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008757-T01-IM5 2724807 2583628 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51859662 COSM6964726 133212723 c.2106A>C p.L702F Substitution - Missense het 38 7:55174778-55174778 + - PATHOGENIC .7109 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu702Phe ENST00000455089.5:c.2106A>C 7:g.55174778A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-2A 2746100 2604803 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51847285 COSM7284415 133258989 c.2893G>A p.V965M Substitution - Missense 38 7:55201269-55201269 + - PATHOGENIC .72324 Confirmed somatic variant 646 NS primary 51 ENSP00000415559.1:p.Val965Met ENST00000455089.5:c.2893G>A 7:g.55201269G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM9-I2 2813459 2669851 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005852-T02-IM5 2722238 2581059 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000370-T01-IM3 2715141 2573962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51849071 COSM6910043 132605042 c.696_697delinsTT p.M232_D233delinsIY Substitution - Missense het 38 7:55154094-55154095 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Met232_Asp233delinsIleTyr ENST00000454757.6:c.696_697delinsTT 7:g.55154094_55154095delinsTT EGFR_ENST00000454757 ENST00000454757.6 3498 3236 83 898378 815990 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51766331 COSM12366 132582479 c.2437C>A p.L813M Substitution - Missense 38 7:55191821-55191821 + - PATHOGENIC .93782 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000395243.3:p.Leu813Met ENST00000454757.6:c.2437C>A 7:g.55191821C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836217 COSM7314292 133234965 c.1279G>T p.A427S Substitution - Missense 38 7:55160254-55160254 + - PATHOGENIC .97432 Confirmed somatic variant 660 NS primary 46 ENSP00000415559.1:p.Ala427Ser ENST00000455089.5:c.1279G>T 7:g.55160254G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-E1-A7YQ-01 2386259 2249091 central_nervous_system brain NS NS glioma NS NS NS y COSV99286607 COSM8256230 133282757 c.1859G>A p.G620D Substitution - Missense 38 7:55173057-55173057 + - PATHOGENIC .9747 Confirmed somatic variant 545 NS primary 58 ENSP00000415559.1:p.Gly620Asp ENST00000455089.5:c.1859G>A 7:g.55173057G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-32-2632-01 2120352 1994588 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 132549948 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 329 NS NS 80 ENSP00000395243.3:p.Leu62Arg ENST00000454757.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2696711 2696711 2555615 oesophagus upper_third NS NS other metaplasia epidermoid NS n COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28731047 surgery-fixed primary 62 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812111 2812111 2668565 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 circulating tumour NS 73 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005763-T01-IM5 2722150 2580971 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PC-9BRc1 2015227 1897435 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 23733853 cell-line NS ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2014_Lung_sq_70_T 2744941 2603644 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 48 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2014_Lung_sq_70_T 2744941 2603644 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 48 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005464-T01-IM5 2721855 2580676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876057 2876057 2730572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 56 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211131 1211131 1122999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen metastasis 45 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009272-T01-IM5 2725229 2584050 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51806679 COSM6967939 132593551 c.3145A>T p.N1049Y Substitution - Missense het 38 7:55205264-55205264 + - PATHOGENIC .98082 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Asn1049Tyr ENST00000454757.6:c.3145A>T 7:g.55205264A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-B0-4822-01 2120426 1994662 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51848907 COSM3366976 133225328 c.841T>C p.C281R Substitution - Missense 38 7:55155916-55155916 + - PATHOGENIC .98755 Confirmed somatic variant 416 NS NS 78 ENSP00000415559.1:p.Cys281Arg ENST00000455089.5:c.841T>C 7:g.55155916T>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876603 2876603 2731118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 132560202 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 60 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2254T>A 7:g.55181398T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM9-I2 2813459 2669851 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005303-T01-IM5 2721704 2580525 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51769031 COSM21690 132546897 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000395243.3:p.Gly553Val ENST00000454757.6:c.1658G>T 7:g.55165350G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000686-T01-IM3 2715784 2574605 skin NS NS NS malignant_melanoma NS NS NS n COSV51781521 COSM6912042 132595592 c.2920C>T p.P974S Substitution - Missense het 38 7:55201296-55201296 + - PATHOGENIC .99234 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Pro974Ser ENST00000454757.6:c.2920C>T 7:g.55201296C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1131222 1131222 1044000 upper_aerodigestive_tract pharynx oropharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51770694 COSM20891 132562677 c.2251G>A p.G751S Substitution - Missense het 38 7:55181395-55181395 + - PATHOGENIC .98244 Confirmed somatic variant 18528899 fresh/frozen - NOS NS 53 ENSP00000395243.3:p.Gly751Ser ENST00000454757.6:c.2251G>A 7:g.55181395G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-CN-4742-01 2193489 2061767 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825459 COSM122789 133214097 c.1288A>G p.I430V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Confirmed somatic variant 627 NS NS 48 ENSP00000415559.1:p.Ile430Val ENST00000455089.5:c.1288A>G 7:g.55160263A>G EGFR ENST00000275493.6 3633 3236 TCGA-12-0616 2108021 1985882 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 1091710 1091710 1006532 lung NS NS NS carcinoma undifferentiated_carcinoma NS NS n COSM26140 178384130 c.? p.G729R Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS EGFR ENST00000275493.6 3633 3236 5-2A 2746100 2604803 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51847285 COSM7284415 99436105 c.3028G>A p.V1010M Substitution - Missense 38 7:55201269-55201269 + - PATHOGENIC .72324 Confirmed somatic variant 646 NS primary 51 ENSP00000275493.2:p.Val1010Met ENST00000275493.6:c.3028G>A 7:g.55201269G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1790528 1790528 1693507 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767379 COSM85894 133213549 c.2392G>A p.V798I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000415559.1:p.Val798Ile ENST00000455089.5:c.2392G>A 7:g.55191776G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005006 1005006 922218 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982868 982868 898587 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103780 1103780 1018032 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471546 1471546 1395285 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471551 1471551 1395290 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920107 920107 837186 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery-fixed NS 37 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 914589 914589 832038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0003170-T01-IM5 2719663 2578484 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51841905 COSM6926730 132550703 c.796T>C p.C266R Substitution - Missense het 38 7:55155871-55155871 + - PATHOGENIC .98694 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Cys266Arg ENST00000454757.6:c.796T>C 7:g.55155871T>C EGFR ENST00000275493.6 3633 3236 TCGA-E1-A7YQ-01 2386259 2249091 central_nervous_system brain NS NS glioma NS NS NS y COSV99286607 COSM8256230 99458524 c.1994G>A p.G665D Substitution - Missense 38 7:55173057-55173057 + - PATHOGENIC .9747 Confirmed somatic variant 545 NS primary 58 ENSP00000275493.2:p.Gly665Asp ENST00000275493.6:c.1994G>A 7:g.55173057G>A EGFR ENST00000275493.6 3633 3236 17234 1423805 1333833 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1460124 1460124 1384001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51770762 COSM52933 132600024 c.2396T>C p.L799P Substitution - Missense 38 7:55191780-55191780 + - PATHOGENIC .97813 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000395243.3:p.Leu799Pro ENST00000454757.6:c.2396T>C 7:g.55191780T>C EGFR ENST00000275493.6 3633 3236 P-0004523-T01-IM5 2829761 2685576 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51780877 COSM26717 99375410 c.2579A>T p.K860I Substitution - Missense 38 7:55191828-55191828 + - PATHOGENIC .95726 Confirmed somatic variant 30205045 surgery-fixed metastasis 58 ENSP00000275493.2:p.Lys860Ile ENST00000275493.6:c.2579A>T 7:g.55191828A>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 86770 1520642 1443017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51850613 COSM94183 132600052 c.2135A>T p.K712M Substitution - Missense 38 7:55174807-55174807 + - PATHOGENIC .99468 Confirmed somatic variant 20668451 NS primary ENSP00000395243.3:p.Lys712Met ENST00000454757.6:c.2135A>T 7:g.55174807A>T EGFR ENST00000275493.6 3633 3236 TCGA-71-8520-01 2194759 2063037 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1001248 1001248 918471 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471559 1471559 1395298 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A014-T-S25 2758134 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 16913 1423755 1333783 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense hom 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0009957-T01-IM5 2725784 2584605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1505378 1505378 1428252 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000583-T01-IM3 2715566 2574387 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1206737 1206737 1118615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 CHG-13-09220T 2634310 2494706 liver NS NS NS other neoplasm NS NS y COSV51802176 COSM6258054 99456774 c.111G>T p.K37N Substitution - Missense 38 7:55142308-55142308 + - PATHOGENIC .84286 Confirmed somatic variant 660 NS primary 67 ENSP00000275493.2:p.Lys37Asn ENST00000275493.6:c.111G>T 7:g.55142308G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GYWU_937 2771256 2629453 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 GYWU_937 2771256 2629453 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-FG-A87Q-01 2339613 2204596 central_nervous_system brain NS NS glioma NS NS NS y COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 545 NS primary 61 ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR ENST00000275493.6 3633 3236 1594193 1594193 1515167 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51804843 COSM12429 99380902 c.2573_2574delinsGT p.L858R Substitution - Missense het 38 7:55191822-55191823 + - Confirmed somatic variant 19726454 surgery fresh/frozen primary 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573_2574delinsGT 7:g.55191822_55191823delinsGT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-VS034-T2 2869859 2724856 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51802355 COSM6941144 133204776 c.1019C>T p.P340L Substitution - Missense 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 26950094 surgery - NOS NS 75 ENSP00000415559.1:p.Pro340Leu ENST00000455089.5:c.1019C>T 7:g.55156779C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0009535-T01-IM5 2725452 2584273 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BF-A1PU-01 2262877 2129861 skin NS NS NS malignant_melanoma NS NS NS y COSV99285705 COSM7864762 133216970 c.2666C>A p.P889H Substitution - Missense 38 7:55198816-55198816 + - PATHOGENIC .98141 Confirmed somatic variant 540 NS primary 46 ENSP00000415559.1:p.Pro889His ENST00000455089.5:c.2666C>A 7:g.55198816C>A EGFR ENST00000275493.6 3633 3236 1790528 1790528 1693507 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51767379 COSM85894 99384993 c.2527G>A p.V843I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000275493.2:p.Val843Ile ENST00000275493.6:c.2527G>A 7:g.55191776G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1472951 1472951 1396650 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51853438 COSM53289 133247821 c.2263G>A p.D755N Substitution - Missense 38 7:55181407-55181407 + - PATHOGENIC .96481 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000415559.1:p.Asp755Asn ENST00000455089.5:c.2263G>A 7:g.55181407G>A EGFR ENST00000275493.6 3633 3236 P-0005945-T01-IM5 2722328 2581149 haematopoietic_and_lymphoid_tissue lymph_node NS NS lymphoid_neoplasm follicular_lymphoma NS NS n COSV51837186 COSM1090861 99388940 c.442G>A p.V148M Substitution - Missense het 38 7:55146623-55146623 + - PATHOGENIC .99004 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Val148Met ENST00000275493.6:c.442G>A 7:g.55146623G>A EGFR ENST00000275493.6 3633 3236 2812083 2812083 2668551 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51830861 COSM6219 99378340 c.2248G>C p.A750P Substitution - Missense 38 7:55174785-55174785 + - PATHOGENIC .99356 Confirmed somatic variant 31534501 circulating tumour NS 68 ENSP00000275493.2:p.Ala750Pro ENST00000275493.6:c.2248G>C 7:g.55174785G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1713253 1713253 1620987 peritoneum NS NS NS mesothelioma epithelial NS NS n COSV51793933 COSM250050 132603810 c.2435G>A p.G812E Substitution - Missense het 38 7:55191819-55191819 + - PATHOGENIC .98882 Confirmed somatic variant 22412050 surgery-fixed NS 41 ENSP00000395243.3:p.Gly812Glu ENST00000454757.6:c.2435G>A 7:g.55191819G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-EB-A431-01 2121600 1995836 skin NS NS NS malignant_melanoma NS NS NS y COSV51820698 COSM3639725 133230901 c.545C>T p.S182F Substitution - Missense 38 7:55152597-55152597 + - NEUTRAL .18615 Confirmed somatic variant 540 NS NS 34 ENSP00000415559.1:p.Ser182Phe ENST00000455089.5:c.545C>T 7:g.55152597C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T116 2658237 2518396 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51773524 COSM1090858 132549299 c.418T>G p.L140V Substitution - Missense 38 7:55143482-55143482 + - NEUTRAL .25717 Confirmed somatic variant 27149842 NS NS 52.58 ENSP00000395243.3:p.Leu140Val ENST00000454757.6:c.418T>G 7:g.55143482T>G EGFR ENST00000275493.6 3633 3236 EXTERN_MELA_20140924_049 2839381 2695147 skin neck NS NS malignant_melanoma NS NS NS y COSV104576959 COSM9291837 99426280 c.3451T>A p.F1151I Substitution - Missense 38 7:55205435-55205435 + - NEUTRAL .31568 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000275493.2:p.Phe1151Ile ENST00000275493.6:c.3451T>A 7:g.55205435T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812111 2812111 2668565 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 31534501 circulating tumour NS 73 ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471564 1471564 1395303 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 EOPC-126_tumor_01 2633717 2494113 prostate NS NS NS carcinoma NS NS NS y COSV51793336 COSM6214981 132580644 c.1528T>C p.C510R Substitution - Missense 38 7:55163764-55163764 + - PATHOGENIC .99407 Confirmed somatic variant 534 NS primary 47 ENSP00000395243.3:p.Cys510Arg ENST00000454757.6:c.1528T>C 7:g.55163764T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MTP6_T1 2875766 2730344 pancreas NS NS NS other dysplasia-in_situ_neoplasm NS NS y COSV51779524 COSM18425 133207486 c.2021G>A p.G674D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Confirmed somatic variant 32796935 surgery-fixed NS 65 ENSP00000415559.1:p.Gly674Asp ENST00000455089.5:c.2021G>A 7:g.55174015G>A EGFR ENST00000275493.6 3633 3236 2638655 2638655 2499028 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 28572531 circulating tumour recurrent 56 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-VQ-A8P5-01 2339762 2204745 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51780766 COSM219795 132546924 c.2456C>T p.A819V Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .93098 Confirmed somatic variant 541 NS primary 67 ENSP00000395243.3:p.Ala819Val ENST00000454757.6:c.2456C>T 7:g.55191840C>T EGFR ENST00000275493.6 3633 3236 1471565 1471565 1395304 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 982788 982788 898507 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766331 COSM12366 99418284 c.2572C>A p.L858M Substitution - Missense 38 7:55191821-55191821 + - PATHOGENIC .93782 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Met ENST00000275493.6:c.2572C>A 7:g.55191821C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009449-T01-IM5 2725376 2584197 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 P-0010345-T01-IM5 2726113 2584934 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-C5-A1BM-01 2193409 2061687 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51807972 COSM4826400 133257275 c.2232C>G p.I744M Substitution - Missense 38 7:55181376-55181376 + - PATHOGENIC .85141 Confirmed somatic variant 415 NS NS 78 ENSP00000415559.1:p.Ile744Met ENST00000455089.5:c.2232C>G 7:g.55181376C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 GBM18-I1 2813453 2669845 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769451 COSM26036 132598302 c.2471A>G p.Y824C Substitution - Missense 38 7:55191855-55191855 + - PATHOGENIC .986 Confirmed somatic variant 28263318 surgery fresh/frozen NS 40 ENSP00000395243.3:p.Tyr824Cys ENST00000454757.6:c.2471A>G 7:g.55191855A>G EGFR ENST00000275493.6 3633 3236 1458680 1458680 1382655 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489241 1489241 1412399 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 KD534 1004976 922188 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2811937 2811937 2668488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 pleural effusion metastasis 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DU-A5TY-01 2194202 2062480 central_nervous_system brain NS NS glioma NS NS NS y COSV51765881 COSM3929118 133261401 c.814G>A p.E272K Substitution - Missense 38 7:55155889-55155889 + - PATHOGENIC .99356 Confirmed somatic variant 545 NS NS 46 ENSP00000415559.1:p.Glu272Lys ENST00000455089.5:c.814G>A 7:g.55155889G>A EGFR ENST00000275493.6 3633 3236 2591485 2591485 2452445 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1468100 1468100 1391946 peritoneum NS NS NS mesothelioma NS NS NS n COSV51815934 COSM28607 133206383 c.2468A>G p.E823G Substitution - Missense het 38 7:55191852-55191852 + - PATHOGENIC .96745 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000415559.1:p.Glu823Gly ENST00000455089.5:c.2468A>G 7:g.55191852A>G EGFR ENST00000275493.6 3633 3236 P-0008757-T01-IM5 2724807 2583628 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51859662 COSM6964726 99384141 c.2241A>C p.L747F Substitution - Missense het 38 7:55174778-55174778 + - PATHOGENIC .7109 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu747Phe ENST00000275493.6:c.2241A>C 7:g.55174778A>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 T116 2658237 2518396 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51787894 COSM6652229 132578797 c.84G>T p.K28N Substitution - Missense 38 7:55019361-55019361 + - NEUTRAL .32765 Confirmed somatic variant 27149842 NS NS 52.58 ENSP00000395243.3:p.Lys28Asn ENST00000454757.6:c.84G>T 7:g.55019361G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 s_IG_thy_023_P 2760359 2618892 thyroid NS NS NS carcinoma NS NS NS n COSV51860085 COSM7339210 132588407 c.3367G>T p.D1123Y Substitution - Missense 38 7:55205486-55205486 + - PATHOGENIC .97405 Confirmed somatic variant 28634282 surgery-fixed primary ENSP00000395243.3:p.Asp1123Tyr ENST00000454757.6:c.3367G>T 7:g.55205486G>T EGFR ENST00000275493.6 3633 3236 2862370 2862370 2717557 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSM9609581 178380982 c.? p.A698T Substitution - Missense + - Confirmed somatic variant 29535832 surgery-fixed NS 67 ENSP00000275493.2:p.Ala698Thr EGFR_ENST00000454757 ENST00000454757.6 3498 3236 86770 1520642 1443017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20668451 NS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0002523-T01-IM3 2718789 2577610 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0010131-T01-IM5 2725939 2584760 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876044 2876044 2730559 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 52 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920025 920025 837104 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 52 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2152770 2152770 2021780 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 CT241 2393070 2255901 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 55 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 920019 920019 837098 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 132546859 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 68 ENSP00000395243.3:p.Leu813Arg ENST00000454757.6:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0002450-T01-IM3 2718725 2577546 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51777313 COSM13006 99375717 c.2320G>A p.V774M Substitution - Missense het 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Val774Met ENST00000275493.6:c.2320G>A 7:g.55181329G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 17218 1423801 1333829 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51785911 COSM48912 132608605 c.1216_1217delinsTT p.R406F Substitution - Missense het 38 7:55160191-55160192 + - Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000395243.3:p.Arg406Phe ENST00000454757.6:c.1216_1217delinsTT 7:g.55160191_55160192delinsTT EGFR ENST00000275493.6 3633 3236 2876051 2876051 2730566 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 78 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876630 2876630 2731145 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 S_TBL200_R3 2757767 2616341 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29106415 surgery - NOS metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002491-T01-IM3 2718763 2577584 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002085-T02-IM5 2719477 2578298 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 NS metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1594195 1594195 1515169 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51786984 COSM133564 132588749 c.2929G>A p.G977S Substitution - Missense hom 38 7:55201305-55201305 + - PATHOGENIC .97265 Confirmed somatic variant 19726454 surgery fresh/frozen primary 61 ENSP00000395243.3:p.Gly977Ser ENST00000454757.6:c.2929G>A 7:g.55201305G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1040346 1040346 956923 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_II NS NS n COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 2591427 2591427 2452387 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2638655 2638655 2499028 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 28572531 circulating tumour recurrent 56 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-B0-4849-01 2120441 1994677 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51791922 COSM3366979 133237031 c.2377C>A p.L793M Substitution - Missense 38 7:55191761-55191761 + - PATHOGENIC .88511 Confirmed somatic variant 416 NS NS 51 ENSP00000415559.1:p.Leu793Met ENST00000455089.5:c.2377C>A 7:g.55191761C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211143 1211143 1123011 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 50 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876048 2876048 2730563 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 44 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1211144 1211144 1123012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen metastasis 70 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876626 2876626 2731141 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 69 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876603 2876603 2731118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 60 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1468097 1468097 1391943 peritoneum NS NS NS mesothelioma NS NS NS n COSV51801471 COSM53105 99379999 c.2492G>A p.R831H Substitution - Missense het 38 7:55191741-55191741 + - PATHOGENIC .96289 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000275493.2:p.Arg831His ENST00000275493.6:c.2492G>A 7:g.55191741G>A EGFR ENST00000275493.6 3633 3236 2308781 2308781 2173984 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM4745830 178383780 c.? p.E866D Substitution - Missense + - Confirmed somatic variant 24510240 surgery - NOS NS ENSP00000275493.2:p.Glu866Asp EGFR_ENST00000454757 ENST00000454757.6 3498 3236 BK0004 2237563 2105067 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51826868 COSM4185521 132585468 c.2505G>T p.W835C Substitution - Missense 38 7:55192780-55192780 + - PATHOGENIC .96888 Confirmed somatic variant 24504440 surgery - NOS NS ENSP00000395243.3:p.Trp835Cys ENST00000454757.6:c.2505G>T 7:g.55192780G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 PD5757a 1465371 1389218 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51785945 COSM4384127 132593579 c.2591C>G p.T864S Substitution - Missense 38 7:55198741-55198741 + - PATHOGENIC .992 Confirmed somatic variant 24030381 NS NS ENSP00000395243.3:p.Thr864Ser ENST00000454757.6:c.2591C>G 7:g.55198741C>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 RK308_C01 2194686 2062964 liver NS NS NS carcinoma NS NS NS y COSV51780206 COSM12373 132553376 c.2024C>T p.S675F Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .9768 Confirmed somatic variant 322 NS NS ENSP00000395243.3:p.Ser675Phe ENST00000454757.6:c.2024C>T 7:g.55174018C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0005943-T01-IM5 2722326 2581147 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51829196 COSM6947106 132561496 c.3068G>A p.R1023Q Substitution - Missense het 38 7:55202557-55202557 + - PATHOGENIC .97786 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000395243.3:p.Arg1023Gln ENST00000454757.6:c.3068G>A 7:g.55202557G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-56-8304-01 2385872 2248704 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99294789 COSM8694245 133228453 c.259G>T p.G87C Substitution - Missense 38 7:55143323-55143323 + - PATHOGENIC .99526 Confirmed somatic variant 418 NS primary 73 ENSP00000415559.1:p.Gly87Cys ENST00000455089.5:c.259G>T 7:g.55143323G>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-4W-AA9T-01 2339571 2204554 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 132550940 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS primary 54 ENSP00000395243.3:p.Ala244Val ENST00000454757.6:c.731C>T 7:g.55154129C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0012194-T01-IM5 2727317 2586138 skin NS NS NS malignant_melanoma NS NS NS n COSV51860991 COSM6983544 132555763 c.97_98delinsAA p.G33N Substitution - Missense het 38 7:55142294-55142295 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000395243.3:p.Gly33Asn ENST00000454757.6:c.97_98delinsAA 7:g.55142294_55142295delinsAA EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0016773-T01-IM6 2830871 2686686 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV104577018 COSM9359626 133222673 c.3082C>A p.P1028T Substitution - Missense 38 7:55202571-55202571 + - PATHOGENIC .97286 Confirmed somatic variant 30205045 surgery-fixed primary 77 ENSP00000415559.1:p.Pro1028Thr ENST00000455089.5:c.3082C>A 7:g.55202571C>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 P-0000681-T02-IM5 2719371 2578192 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 132547947 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000395243.3:p.Gly674Ala ENST00000454757.6:c.2021G>C 7:g.55174015G>C EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-A8-A094-01 1779383 1683382 breast NS NS NS carcinoma NS NS NS y COSV51768800 COSM6499385 132568179 c.709G>A p.E237K Substitution - Missense 38 7:55154107-55154107 + - PATHOGENIC .81806 Confirmed somatic variant 414 fresh/frozen - NOS primary 75 ENSP00000395243.3:p.Glu237Lys ENST00000454757.6:c.709G>A 7:g.55154107G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51816377 COSM3412194 133203358 c.1651C>T p.P551S Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99531 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000415559.1:p.Pro551Ser ENST00000455089.5:c.1651C>T 7:g.55165343C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 1486996 1486996 1410614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51811013 COSM85960 132615107 c.2126A>G p.K709R Substitution - Missense 38 7:55174798-55174798 + - PATHOGENIC .9918 Confirmed somatic variant 16567021 surgery-fixed primary 68 ENSP00000395243.3:p.Lys709Arg ENST00000454757.6:c.2126A>G 7:g.55174798A>G EGFR_ENST00000454757 ENST00000454757.6 3498 3236 TCGA-06-0878-01 1337866 1248251 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 132547099 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 74 ENSP00000395243.3:p.Ala244Thr ENST00000454757.6:c.730G>A 7:g.55154128G>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 Case6 1943622 1830532 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 23563269 NS NS 75 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876600 2876600 2731115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 132546873 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 42 ENSP00000395243.3:p.Thr745Met ENST00000454757.6:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010180-T01-IM5 2725979 2584800 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000454757 ENST00000454757.6 3498 3236 2876600 2876600 2731115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 132563575 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 42 ENSP00000395243.3:p.Cys752Ser ENST00000454757.6:c.2255G>C 7:g.55181399G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 587220 1766747 1671067 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51792177 COSM1205050 133209467 c.1144C>T p.R382C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 22895193 surgery fresh/frozen primary ENSP00000415559.1:p.Arg382Cys ENST00000455089.5:c.1144C>T 7:g.55157734C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 SJHYPO052-D 2590140 2451270 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 133209467 c.1144C>T p.R382C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 23334668 blood-bone marrow NS 16.3 ENSP00000415559.1:p.Arg382Cys ENST00000455089.5:c.1144C>T 7:g.55157734C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T1244 2658449 2518608 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 133212226 c.1445G>A p.R482Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 62.75 ENSP00000415559.1:p.Arg482Gln ENST00000455089.5:c.1445G>A 7:g.55161580G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836251 COSM6348839 133234999 c.1392G>T p.L464F Substitution - Missense 38 7:55161527-55161527 + - PATHOGENIC .8964 Confirmed somatic variant 660 NS primary 46 ENSP00000415559.1:p.Leu464Phe ENST00000455089.5:c.1392G>T 7:g.55161527G>T EGFR ENST00000275493.6 3633 3236 2856498 2856498 2711825 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSM9522567 178379362 c.? p.A871T Substitution - Missense + - Confirmed somatic variant 31799787 surgery-fixed NS ENSP00000275493.2:p.Ala871Thr EGFR ENST00000275493.6 3633 3236 P-0003169-T01-IM5 2719662 2578483 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 2492700 2492700 2355315 skin face NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 99401924 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen primary ENSP00000275493.2:p.His47Tyr ENST00000275493.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-VS091-T1 2869923 2724920 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51822575 COSM6932208 133216451 c.2639C>T p.S880F Substitution - Missense 38 7:55198789-55198789 + - NEUTRAL .37023 Confirmed somatic variant 26950094 surgery - NOS NS 90 ENSP00000415559.1:p.Ser880Phe ENST00000455089.5:c.2639C>T 7:g.55198789C>T EGFR ENST00000275493.6 3633 3236 S04-45633-TP 2366567 2229450 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51801932 COSM4992971 99423745 c.2288C>T p.A763V Substitution - Missense het 38 7:55181297-55181297 + - PATHOGENIC .97799 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000275493.2:p.Ala763Val ENST00000275493.6:c.2288C>T 7:g.55181297C>T EGFR ENST00000275493.6 3633 3236 TCGA-DU-5852-01 2194247 2062525 central_nervous_system brain NS NS glioma NS NS NS y COSV51787357 COSM3929123 99386759 c.2941A>T p.I981F Substitution - Missense 38 7:55200408-55200408 + - PATHOGENIC .9931 Confirmed somatic variant 545 NS NS 61 ENSP00000275493.2:p.Ile981Phe ENST00000275493.6:c.2941A>T 7:g.55200408A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T3265 2658621 2518780 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51815655 COSM6652276 133284664 c.778G>A p.G260S Substitution - Missense 38 7:55155853-55155853 + - PATHOGENIC .97718 Confirmed somatic variant 27149842 NS NS 74.91 ENSP00000415559.1:p.Gly260Ser ENST00000455089.5:c.778G>A 7:g.55155853G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CH-LA8 2211434 2079637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24449147 surgery fresh/frozen NS 67 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876665 2876665 2731180 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 42 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 961852 961852 878136 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16467080 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CT207 2393063 2255894 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 71 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004987 1004987 922199 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1489243 1489243 1412401 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 69 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1103793 1103793 1018045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-MP-A4SW-01 2194827 2063105 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 53 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982786 982786 898505 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876042 2876042 2730557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 43 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-26-5139-01 2120327 1994563 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51856614 COSM3412172 99433908 c.668G>A p.C223Y Substitution - Missense 38 7:55152585-55152585 + - PATHOGENIC .99676 Confirmed somatic variant 329 NS NS 65 ENSP00000275493.2:p.Cys223Tyr ENST00000275493.6:c.668G>A 7:g.55152585G>A EGFR ENST00000275493.6 3633 3236 CHC892T 2340454 2205437 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51854735 COSM4794914 99414214 c.3142G>A p.A1048T Substitution - Missense 38 7:55201762-55201762 + - NEUTRAL .20234 Confirmed somatic variant 381 NS primary 72 ENSP00000275493.2:p.Ala1048Thr ENST00000275493.6:c.3142G>A 7:g.55201762G>A EGFR ENST00000275493.6 3633 3236 100097 2807613 2664314 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51841863 COSM6913649 99377584 c.3415C>T p.L1139F Substitution - Missense 38 7:55205399-55205399 + - PATHOGENIC .96614 Confirmed somatic variant 24807215 surgery fresh/frozen primary 62 ENSP00000275493.2:p.Leu1139Phe ENST00000275493.6:c.3415C>T 7:g.55205399C>T EGFR ENST00000275493.6 3633 3236 P-0010864-T01-IM5 2726533 2585354 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51864573 COSM6977465 99383821 c.1117C>T p.P373S Substitution - Missense het 38 7:55156643-55156643 + - PATHOGENIC .91736 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Pro373Ser ENST00000275493.6:c.1117C>T 7:g.55156643C>T EGFR ENST00000275493.6 3633 3236 2591375 2591375 2452335 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 1589268 1589268 1510422 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51809033 COSM133147 99384947 c.2132_2133inv p.E711V Substitution - Missense 38 7:55173991-55173992 + - Confirmed somatic variant 22026926 surgery fresh/frozen NS ENSP00000275493.2:p.Glu711Val ENST00000275493.6:c.2132_2133inv 7:g.55173991_55173992inv EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009451-T01-IM5 2725378 2584199 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002265-T02-IM5 2719496 2578317 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD11341a 1749312 1654153 breast NS NS NS carcinoma ductal_carcinoma mucinous NS y COSV51807785 COSM5782738 133257041 c.1855A>T p.I619F Substitution - Missense 38 7:55173053-55173053 + - PATHOGENIC .88741 Confirmed somatic variant 652 NS NS ENSP00000415559.1:p.Ile619Phe ENST00000455089.5:c.1855A>T 7:g.55173053A>T EGFR ENST00000275493.6 3633 3236 P-0006402-T01-IM5 2722778 2581599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 99373561 c.2155G>A p.G719S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Gly719Ser ENST00000275493.6:c.2155G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 YUMER 2013650 1896282 skin NS NS NS malignant_melanoma NS NS NS y COSV51841339 COSM1698695 99379619 c.2014C>T p.H672Y Substitution - Missense het 38 7:55173077-55173077 + - PATHOGENIC .95363 Confirmed somatic variant 22842228 NS NS ENSP00000275493.2:p.His672Tyr ENST00000275493.6:c.2014C>T 7:g.55173077C>T EGFR ENST00000275493.6 3633 3236 83 898378 815990 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51766331 COSM12366 99418284 c.2572C>A p.L858M Substitution - Missense 38 7:55191821-55191821 + - PATHOGENIC .93782 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Met ENST00000275493.6:c.2572C>A 7:g.55191821C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876630 2876630 2731145 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876051 2876051 2730566 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 78 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S_TBL200_R3 2757767 2616341 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29106415 surgery - NOS metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-06-0237 2107974 1985835 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 P-0011293-T01-IM5 2726897 2585718 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51862653 COSM6980033 99374163 c.1800G>T p.M600I Substitution - Missense het 38 7:55165357-55165357 + - PATHOGENIC .94832 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Met600Ile ENST00000275493.6:c.1800G>T 7:g.55165357G>T EGFR ENST00000275493.6 3633 3236 I2L-P16-Tumor-Organoid 2433496 2296377 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51814923 COSM5358036 99380300 c.559T>C p.C187R Substitution - Missense het 38 7:55146740-55146740 + - PATHOGENIC .98691 Confirmed somatic variant 25957691 NS NS 67 ENSP00000275493.2:p.Cys187Arg ENST00000275493.6:c.559T>C 7:g.55146740T>C EGFR ENST00000275493.6 3633 3236 1005022 1005022 922234 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766618 COSM12374 99378740 c.2582T>G p.L861R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Arg ENST00000275493.6:c.2582T>G 7:g.55191831T>G EGFR ENST00000275493.6 3633 3236 2115502 2115502 1989746 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2591375 2591375 2452335 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 zcc203 2873641 2728634 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS y COSV99297135 COSM9212199 99396720 c.865G>T p.A289S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 33020650 surgery fresh/frozen NS ENSP00000275493.2:p.Ala289Ser ENST00000275493.6:c.865G>T 7:g.55154128G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003169-T01-IM5 2719662 2578483 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-76-4926-01 2120378 1994614 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 68 ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003850-T01-IM5 2720342 2579163 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-0656-01 2178172 2046470 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 133205223 c.731C>A p.A244D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 NS NS 48 ENSP00000415559.1:p.Ala244Asp ENST00000455089.5:c.731C>A 7:g.55154129C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000573-T01-IM3 2715544 2574365 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51795632 COSM26509 133221986 c.2092G>A p.A698T Substitution - Missense het 38 7:55174764-55174764 + - PATHOGENIC .99624 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ala698Thr ENST00000455089.5:c.2092G>A 7:g.55174764G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1595812 1595812 1516609 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51767379 COSM85894 133213549 c.2392G>A p.V798I Substitution - Missense het 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 16551849 surgery-fixed NS 60 ENSP00000415559.1:p.Val798Ile ENST00000455089.5:c.2392G>A 7:g.55191776G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DU-5852-01 2194247 2062525 central_nervous_system brain NS NS glioma NS NS NS y COSV51787357 COSM3929123 133215132 c.2806A>T p.I936F Substitution - Missense 38 7:55200408-55200408 + - PATHOGENIC .9931 Confirmed somatic variant 545 NS NS 61 ENSP00000415559.1:p.Ile936Phe ENST00000455089.5:c.2806A>T 7:g.55200408A>T EGFR ENST00000275493.6 3633 3236 2901991 2901991 2756229 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 P-0003850-T01-IM5 2720342 2579163 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 TCGA-76-4926-01 2120378 1994614 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 68 ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 1595812 1595812 1516609 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51767379 COSM85894 99384993 c.2527G>A p.V843I Substitution - Missense het 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 16551849 surgery-fixed NS 60 ENSP00000275493.2:p.Val843Ile ENST00000275493.6:c.2527G>A 7:g.55191776G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-HT-A5RC-01 2194260 2062538 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 70 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DU-7013-01 2194399 2062677 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 59 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-76-4931-01 2120382 1994618 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 70 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1472951 1472951 1396650 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51853450 COSM53290 133208421 c.2480A>G p.E827G Substitution - Missense 38 7:55191864-55191864 + - PATHOGENIC .986 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000415559.1:p.Glu827Gly ENST00000455089.5:c.2480A>G 7:g.55191864A>G EGFR ENST00000275493.6 3633 3236 TCGA-TM-A7C3-01 2262979 2129963 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 43 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 982786 982786 898505 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767386 COSM18423 99393803 c.2500G>T p.V834L Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .9903 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Val834Leu ENST00000275493.6:c.2500G>T 7:g.55191749G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-IQ-7630-01 2193638 2061916 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51792433 COSM6966446 133237386 c.1627G>A p.G543S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 627 NS NS 49 ENSP00000415559.1:p.Gly543Ser ENST00000455089.5:c.1627G>A 7:g.55165319G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011293-T01-IM5 2726897 2585718 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51862653 COSM6980033 133202790 c.1665G>T p.M555I Substitution - Missense het 38 7:55165357-55165357 + - PATHOGENIC .94832 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Met555Ile ENST00000455089.5:c.1665G>T 7:g.55165357G>T EGFR ENST00000275493.6 3633 3236 1468657 1468657 1392408 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-EE-A2GO-06 2121665 1995901 skin NS NS NS malignant_melanoma NS NS NS y COSV51784231 COSM3639757 133212507 c.2890G>A p.D964N Substitution - Missense 38 7:55201266-55201266 + - PATHOGENIC .98192 Confirmed somatic variant 540 NS NS 66 ENSP00000415559.1:p.Asp964Asn ENST00000455089.5:c.2890G>A 7:g.55201266G>A EGFR ENST00000275493.6 3633 3236 TCGA-32-2632-01 2120352 1994588 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 99376737 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 329 NS NS 80 ENSP00000275493.2:p.Leu62Arg ENST00000275493.6:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 R074-I1 2813495 2669887 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99297135 COSM9212199 99396720 c.865G>T p.A289S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 28263318 surgery fresh/frozen NS 41 ENSP00000275493.2:p.Ala289Ser ENST00000275493.6:c.865G>T 7:g.55154128G>T EGFR ENST00000275493.6 3633 3236 1468558 1468558 1392309 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1595807 1595807 1516604 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51841095 COSM133588 133224594 c.2135A>G p.K712R Substitution - Missense hom 38 7:55174807-55174807 + - PATHOGENIC .9946 Confirmed somatic variant 16551849 surgery-fixed NS 66 ENSP00000415559.1:p.Lys712Arg ENST00000455089.5:c.2135A>G 7:g.55174807A>G EGFR ENST00000275493.6 3633 3236 2675068 2675068 2534343 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 29110836 surgery-fixed recurrent 55 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591353 2591353 2452313 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 P-0006924-T01-IM5 2723304 2582125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773712 COSM13433 99385694 c.2318A>G p.H773R Substitution - Missense het 38 7:55181327-55181327 + - PATHOGENIC .98391 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.His773Arg ENST00000275493.6:c.2318A>G 7:g.55181327A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876666 2876666 2731181 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51789261 COSM12986 133218176 c.2294G>A p.G765D Substitution - Missense 38 7:55181438-55181438 + - PATHOGENIC .98244 Confirmed somatic variant 29506987 pleural effusion NS 64 ENSP00000415559.1:p.Gly765Asp ENST00000455089.5:c.2294G>A 7:g.55181438G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1468093 1468093 1391939 peritoneum NS NS NS mesothelioma NS NS NS n COSV51847876 COSM53102 133271975 c.2065G>C p.E689Q Substitution - Missense het 38 7:55174737-55174737 + - PATHOGENIC .99895 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000415559.1:p.Glu689Gln ENST00000455089.5:c.2065G>C 7:g.55174737G>C EGFR ENST00000275493.6 3633 3236 BC85-ctDNA 2668219 2527792 breast NS NS NS carcinoma NS NS NS y COSV51834499 COSM6845063 99375657 c.964G>A p.G322S Substitution - Missense het 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 27535334 circulating tumour metastasis ENSP00000275493.2:p.Gly322Ser ENST00000275493.6:c.964G>A 7:g.55155904G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 133206295 c.775C>T p.H259Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000415559.1:p.His259Tyr ENST00000455089.5:c.775C>T 7:g.55155850C>T EGFR ENST00000275493.6 3633 3236 945817 945817 862343 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 16144918 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005511-T02-IM5 2721904 2580725 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51836402 COSM6944131 133222597 c.2219C>G p.T740S Substitution - Missense het 38 7:55181363-55181363 + - PATHOGENIC .951 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Thr740Ser ENST00000455089.5:c.2219C>G 7:g.55181363C>G EGFR ENST00000275493.6 3633 3236 1113157 1113157 1026658 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 18450321 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468639 1468639 1392390 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 198 898387 815999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458685 1458685 1382660 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876655 2876655 2731170 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 70 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 17234 1423805 1333833 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982854 982854 898573 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489250 1489250 1412408 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206714 1206714 1118592 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0010267-T01-IM5 2726054 2584875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458698 1458698 1382673 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876666 2876666 2731181 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 pleural effusion NS 64 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1004997 1004997 922209 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009451-T01-IM5 2725378 2584199 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51781835 COSM174732 133207258 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Glu114Lys ENST00000455089.5:c.340G>A 7:g.55143404G>A EGFR ENST00000275493.6 3633 3236 1498503 1498503 1421381 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Confirmed somatic variant 21040950 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Ser EGFR ENST00000275493.6 3633 3236 P-0012079-T01-IM5 2727221 2586042 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 4991 915993 833392 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152782 2152782 2021792 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 911963 911963 829455 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15780185 NS NS 50 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 860 898395 816007 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2308793 2308793 2173996 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM4745832 178390162 c.? p.A597P Substitution - Missense + - Confirmed somatic variant 24510240 surgery - NOS NS ENSP00000275493.2:p.Ala597Pro EGFR ENST00000275493.6 3633 3236 P-0004666-T01-IM5 2721066 2579887 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 99387971 c.1474A>C p.S492R Substitution - Missense het 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Ser492Arg ENST00000275493.6:c.1474A>C 7:g.55160314A>C EGFR ENST00000275493.6 3633 3236 77 897189 814812 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51777782 COSM6227 99381636 c.2504A>T p.H835L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000275493.2:p.His835Leu ENST00000275493.6:c.2504A>T 7:g.55191753A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 3595 915982 833381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920020 920020 837099 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 72 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460155 1460155 1384032 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982867 982867 898586 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458687 1458687 1382662 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0000573-T01-IM3 2715544 2574365 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51795632 COSM26509 99395627 c.2227G>A p.A743T Substitution - Missense het 38 7:55174764-55174764 + - PATHOGENIC .99624 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ala743Thr ENST00000275493.6:c.2227G>A 7:g.55174764G>A EGFR ENST00000275493.6 3633 3236 1595809 1595809 1516606 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 16551849 surgery-fixed NS 61 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0012360-T01-IM5 2727428 2586249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 133205744 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg108Lys ENST00000455089.5:c.323G>A 7:g.55143387G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0012358-T01-IM5 2727426 2586247 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51844677 COSM6984453 133225084 c.2864C>T p.A955V Substitution - Missense het 38 7:55201240-55201240 + - PATHOGENIC .95761 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Ala955Val ENST00000455089.5:c.2864C>T 7:g.55201240C>T EGFR ENST00000275493.6 3633 3236 1505360 1505360 1428238 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51802570 COSM87245 99420464 c.2231T>C p.I744T Substitution - Missense 38 7:55174768-55174768 + - PATHOGENIC .99336 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000275493.2:p.Ile744Thr ENST00000275493.6:c.2231T>C 7:g.55174768T>C EGFR ENST00000275493.6 3633 3236 TCGA-BR-A4QL-01 2197931 2066209 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51771306 COSM1318972 99391332 c.1913C>T p.T638M Substitution - Missense 38 7:55171207-55171207 + - NEUTRAL .03249 Confirmed somatic variant 541 NS NS 75 ENSP00000275493.2:p.Thr638Met ENST00000275493.6:c.1913C>T 7:g.55171207C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006924-T01-IM5 2723304 2582125 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773712 COSM13433 133214162 c.2183A>G p.H728R Substitution - Missense het 38 7:55181327-55181327 + - PATHOGENIC .98391 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.His728Arg ENST00000455089.5:c.2183A>G 7:g.55181327A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876606 2876606 2731121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105111204 COSM9926231 133282397 c.2245C>T p.P749S Substitution - Missense 38 7:55181389-55181389 + - PATHOGENIC .97194 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000415559.1:p.Pro749Ser ENST00000455089.5:c.2245C>T 7:g.55181389C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-26-5139-01 2120327 1994563 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51840469 COSM2157152 133257211 c.1748G>T p.C583F Substitution - Missense 38 7:55171177-55171177 + - PATHOGENIC .98352 Confirmed somatic variant 329 NS NS 65 ENSP00000415559.1:p.Cys583Phe ENST00000455089.5:c.1748G>T 7:g.55171177G>T EGFR ENST00000275493.6 3633 3236 2152755 2152755 2021765 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766268 COSM13183 99377562 c.2225T>C p.V742A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Val742Ala ENST00000275493.6:c.2225T>C 7:g.55174762T>C EGFR ENST00000275493.6 3633 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836217 COSM7314292 99408006 c.1414G>T p.A472S Substitution - Missense 38 7:55160254-55160254 + - PATHOGENIC .97432 Confirmed somatic variant 660 NS primary 46 ENSP00000275493.2:p.Ala472Ser ENST00000275493.6:c.1414G>T 7:g.55160254G>T EGFR ENST00000275493.6 3633 3236 P-0011503-T01-IM5 2727075 2585896 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 99393769 c.1793G>C p.G598A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly598Ala ENST00000275493.6:c.1793G>C 7:g.55165350G>C EGFR ENST00000275493.6 3633 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836251 COSM6348839 99408026 c.1527G>T p.L509F Substitution - Missense 38 7:55161527-55161527 + - PATHOGENIC .8964 Confirmed somatic variant 660 NS primary 46 ENSP00000275493.2:p.Leu509Phe ENST00000275493.6:c.1527G>T 7:g.55161527G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T1154 2296082 2161685 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51814845 COSM4680396 133270956 c.1562C>T p.A521V Substitution - Missense 38 7:55163798-55163798 + - NEUTRAL .08918 Confirmed somatic variant 25344691 NS NS 68.33 ENSP00000415559.1:p.Ala521Val ENST00000455089.5:c.1562C>T 7:g.55163798C>T EGFR ENST00000275493.6 3633 3236 1131222 1131222 1044000 upper_aerodigestive_tract pharynx oropharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51770694 COSM20891 99391373 c.2386G>A p.G796S Substitution - Missense het 38 7:55181395-55181395 + - PATHOGENIC .98244 Confirmed somatic variant 18528899 fresh/frozen - NOS NS 53 ENSP00000275493.2:p.Gly796Ser ENST00000275493.6:c.2386G>A 7:g.55181395G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-12-0616 2108021 1985882 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 TCGA-AR-A0TV-01 1779493 1683492 breast NS NS NS carcinoma NS NS NS y COSV99293406 COSM7679798 99416691 c.1577G>C p.C526S Substitution - Missense 38 7:55161577-55161577 + - PATHOGENIC .9951 Confirmed somatic variant 414 fresh/frozen - NOS primary 66 ENSP00000275493.2:p.Cys526Ser ENST00000275493.6:c.1577G>C 7:g.55161577G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 YUOTHO 2439352 2302193 skin NS NS NS malignant_melanoma NS NS NS y COSV51848994 COSM5407724 133217351 c.1566G>A p.M522I Substitution - Missense het 38 7:55163802-55163802 + - PATHOGENIC .89204 Confirmed somatic variant 26214590 fresh/frozen - NOS primary 87 ENSP00000415559.1:p.Met522Ile ENST00000455089.5:c.1566G>A 7:g.55163802G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DD-AAE3-01 2339647 2204630 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51766284 COSM28512 133205611 c.2095A>G p.I699V Substitution - Missense 38 7:55174767-55174767 + - PATHOGENIC .99591 Confirmed somatic variant 628 NS primary 50 ENSP00000415559.1:p.Ile699Val ENST00000455089.5:c.2095A>G 7:g.55174767A>G EGFR ENST00000275493.6 3633 3236 1713253 1713253 1620987 peritoneum NS NS NS mesothelioma epithelial NS NS n COSV51793933 COSM250050 99444781 c.2570G>A p.G857E Substitution - Missense het 38 7:55191819-55191819 + - PATHOGENIC .98882 Confirmed somatic variant 22412050 surgery-fixed NS 41 ENSP00000275493.2:p.Gly857Glu ENST00000275493.6:c.2570G>A 7:g.55191819G>A EGFR ENST00000275493.6 3633 3236 TCGA-26-5139-01 2120327 1994563 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51840469 COSM2157152 99433926 c.1883G>T p.C628F Substitution - Missense 38 7:55171177-55171177 + - PATHOGENIC .98352 Confirmed somatic variant 329 NS NS 65 ENSP00000275493.2:p.Cys628Phe ENST00000275493.6:c.1883G>T 7:g.55171177G>T EGFR ENST00000275493.6 3633 3236 P-0006402-T01-IM5 2722778 2581599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 99373772 c.2126A>C p.E709A Substitution - Missense het 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Glu709Ala ENST00000275493.6:c.2126A>C 7:g.55173985A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460139 1460139 1384016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790305 COSM13194 133206846 c.2405C>T p.T802I Substitution - Missense 38 7:55191789-55191789 + - PATHOGENIC .95119 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000415559.1:p.Thr802Ile ENST00000455089.5:c.2405C>T 7:g.55191789C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003079-T01-IM5 2719588 2578409 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR ENST00000275493.6 3633 3236 ILMN12 2816772 2673123 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV104369087 COSM9238851 99409114 c.1837G>A p.A613T Substitution - Missense 38 7:55165394-55165394 + - PATHOGENIC .87498 Confirmed somatic variant 29937994 surgery fresh/frozen NS 45 ENSP00000275493.2:p.Ala613Thr ENST00000275493.6:c.1837G>A 7:g.55165394G>A EGFR ENST00000275493.6 3633 3236 P-0005303-T01-IM5 2721704 2580525 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 GBM9-I2 2813459 2669851 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 99373258 c.1793G>T p.G598V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000275493.2:p.Gly598Val ENST00000275493.6:c.1793G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 S02-14875-TP 2366560 2229443 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51780206 COSM12373 99380273 c.2159C>T p.S720F Substitution - Missense het 38 7:55174018-55174018 + - PATHOGENIC .9768 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000275493.2:p.Ser720Phe ENST00000275493.6:c.2159C>T 7:g.55174018C>T EGFR ENST00000275493.6 3633 3236 TCGA-06-0650-01 2120258 1994494 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 329 NS NS 39 ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 P-0002200-T01-IM3 2718492 2577313 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS n COSV51837290 COSM6921325 99396647 c.3335A>G p.N1112S Substitution - Missense het 38 7:55205319-55205319 + - PATHOGENIC .95172 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Asn1112Ser ENST00000275493.6:c.3335A>G 7:g.55205319A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011308-T01-IM5 2726911 2585732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982788 982788 898507 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766331 COSM12366 133243522 c.2437C>A p.L813M Substitution - Missense 38 7:55191821-55191821 + - PATHOGENIC .93782 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Met ENST00000455089.5:c.2437C>A 7:g.55191821C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A102-T-S04 2757412 2616002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 73 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1004985 1004985 922197 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2864407 2864407 2719565 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 31761448 circulating tumour recurrent 63 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591429 2591429 2452389 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2591455 2591455 2452415 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0012083-T01-IM5 2727225 2586046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 ILMN12 2816772 2673123 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV104369087 COSM9238851 133236257 c.1702G>A p.A568T Substitution - Missense 38 7:55165394-55165394 + - PATHOGENIC .87498 Confirmed somatic variant 29937994 surgery fresh/frozen NS 45 ENSP00000415559.1:p.Ala568Thr ENST00000455089.5:c.1702G>A 7:g.55165394G>A EGFR ENST00000275493.6 3633 3236 1113158 1113158 1026659 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 18450321 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468636 1468636 1392387 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1170512 1170512 1082646 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 19117057 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T164221 2658574 2518733 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51767379 COSM85894 133213549 c.2392G>A p.V798I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 27149842 NS NS 72.66 ENSP00000415559.1:p.Val798Ile ENST00000455089.5:c.2392G>A 7:g.55191776G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002450-T01-IM3 2718725 2577546 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51777313 COSM13006 133204004 c.2185G>A p.V729M Substitution - Missense het 38 7:55181329-55181329 + - PATHOGENIC .96725 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Val729Met ENST00000455089.5:c.2185G>A 7:g.55181329G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1595809 1595809 1516606 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 16551849 surgery-fixed NS 61 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 PD42098a 2894843 2749331 skin trunk NS NS malignant_melanoma nodular NS NS y COSV51776967 COSM6963220 99390712 c.1930C>T p.P644S Substitution - Missense 38 7:55172993-55172993 + - PATHOGENIC .96242 Confirmed somatic variant 33024263 surgery-fixed metastasis 42 ENSP00000275493.2:p.Pro644Ser ENST00000275493.6:c.1930C>T 7:g.55172993C>T EGFR ENST00000275493.6 3633 3236 5-NB016-T1 2869816 2724813 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV51776967 COSM6963220 99390712 c.1930C>T p.P644S Substitution - Missense 38 7:55172993-55172993 + - PATHOGENIC .96242 Confirmed somatic variant 26950094 surgery fresh/frozen NS 74 ENSP00000275493.2:p.Pro644Ser ENST00000275493.6:c.1930C>T 7:g.55172993C>T EGFR ENST00000275493.6 3633 3236 P-0003311-T01-IM5 2719805 2578626 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51794846 COSM6927745 99432011 c.3317A>T p.Q1106L Substitution - Missense het 38 7:55205301-55205301 + - PATHOGENIC .70456 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gln1106Leu ENST00000275493.6:c.3317A>T 7:g.55205301A>T EGFR ENST00000275493.6 3633 3236 1451151 1451151 1375294 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1936-ca 2823131 2678985 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 28818608 surgery-fixed NS 55 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1054312 1054312 970383 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 17409862 surgery - NOS primary 69 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1014237 1014237 931411 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 17047397 fixed - NOS primary 65 ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982786 982786 898505 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767386 COSM18423 133220856 c.2365G>T p.V789L Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .9903 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Val789Leu ENST00000455089.5:c.2365G>T 7:g.55191749G>T EGFR ENST00000275493.6 3633 3236 2675070 2675070 2534345 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 29110836 surgery-fixed recurrent 67 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2150411 2150411 2019480 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 62 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2150416 2150416 2019485 lung NS NS NS carcinoma micropapillary_adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 57 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 R074-I1 2813495 2669887 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 41 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 T164221 2658574 2518733 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51767379 COSM85894 99384993 c.2527G>A p.V843I Substitution - Missense 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 27149842 NS NS 72.66 ENSP00000275493.2:p.Val843Ile ENST00000275493.6:c.2527G>A 7:g.55191776G>A EGFR ENST00000275493.6 3633 3236 1472951 1472951 1396650 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51853438 COSM53289 99423412 c.2398G>A p.D800N Substitution - Missense 38 7:55181407-55181407 + - PATHOGENIC .96481 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000275493.2:p.Asp800Asn ENST00000275493.6:c.2398G>A 7:g.55181407G>A EGFR ENST00000275493.6 3633 3236 2591455 2591455 2452415 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM6022951 178383830 c.? p.N826S Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Asn826Ser EGFR ENST00000275493.6 3633 3236 1451158 1451158 1375301 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152755 2152755 2021765 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766268 COSM13183 133205606 c.2090T>C p.V697A Substitution - Missense 38 7:55174762-55174762 + - PATHOGENIC .99336 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Val697Ala ENST00000455089.5:c.2090T>C 7:g.55174762T>C EGFR ENST00000275493.6 3633 3236 1103780 1103780 1018032 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471551 1471551 1395290 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1005006 1005006 922218 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982868 982868 898587 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 914589 914589 832038 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15788655 surgery fresh/frozen primary 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920107 920107 837186 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery-fixed NS 37 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471546 1471546 1395285 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1595812 1595812 1516609 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51848710 COSM26438 133217212 c.2485G>A p.G829S Substitution - Missense het 38 7:55191869-55191869 + - PATHOGENIC .98912 Confirmed somatic variant 16551849 surgery-fixed NS 60 ENSP00000415559.1:p.Gly829Ser ENST00000455089.5:c.2485G>A 7:g.55191869G>A EGFR ENST00000275493.6 3633 3236 MM18T 2457741 2320578 endometrium NS NS NS carcinoma carcinosarcoma-malignant_mesodermal_mixed_tumour NS NS n COSV51810684 COSM5415932 99390833 c.2989T>G p.F997V Substitution - Missense 38 7:55201230-55201230 + - PATHOGENIC .9773 Confirmed somatic variant 25233892 surgery-fixed primary 59 ENSP00000275493.2:p.Phe997Val ENST00000275493.6:c.2989T>G 7:g.55201230T>G EGFR ENST00000275493.6 3633 3236 TCGA-DU-5852-01 2194247 2062525 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 99380629 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS NS 61 ENSP00000275493.2:p.Arg252Cys ENST00000275493.6:c.754C>T 7:g.55154017C>T EGFR ENST00000275493.6 3633 3236 TCGA-E1-A7YJ-01 2457421 2320258 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 99380629 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS primary 55 ENSP00000275493.2:p.Arg252Cys ENST00000275493.6:c.754C>T 7:g.55154017C>T EGFR ENST00000275493.6 3633 3236 2675070 2675070 2534345 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 29110836 surgery-fixed recurrent 67 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2115525 2115525 1989769 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2150411 2150411 2019480 lung NS NS NS carcinoma acinar_adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 24729716 surgery fresh/frozen primary 62 ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 982788 982788 898507 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 TCGA-KT-A7W1-01 2262770 2129754 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 45 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 zcc203 2873641 2728634 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 33020650 surgery fresh/frozen NS ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 982782 982782 898501 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0003274-T01-IM5 2719770 2578591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 S_TBL200_R4 2757768 2616342 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29106415 autopsy - NOS metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1468100 1468100 1391946 peritoneum NS NS NS mesothelioma NS NS NS n COSV51815934 COSM28607 99378283 c.2603A>G p.E868G Substitution - Missense het 38 7:55191852-55191852 + - PATHOGENIC .96745 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000275493.2:p.Glu868Gly ENST00000275493.6:c.2603A>G 7:g.55191852A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009948-T02-IM5 2725775 2584596 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 NB-1204 1898491 1787175 autonomic_ganglia NS NS NS neuroblastoma NS NS NS y COSV51767481 COSM1284692 133213976 c.1787C>A p.P596H Substitution - Missense 38 7:55172985-55172985 + - PATHOGENIC .97992 Confirmed somatic variant 23334666 NS NS ENSP00000415559.1:p.Pro596His ENST00000455089.5:c.1787C>A 7:g.55172985C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A001-T-S04 2757357 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 17739 1423845 1333873 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-06-0650-01 2120258 1994494 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779524 COSM18425 99379336 c.2156G>A p.G719D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Confirmed somatic variant 329 NS NS 39 ENSP00000275493.2:p.Gly719Asp ENST00000275493.6:c.2156G>A 7:g.55174015G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S02-14875-TP 2366560 2229443 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51780206 COSM12373 133208468 c.2024C>T p.S675F Substitution - Missense het 38 7:55174018-55174018 + - PATHOGENIC .9768 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000415559.1:p.Ser675Phe ENST00000455089.5:c.2024C>T 7:g.55174018C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0008757-T01-IM5 2724807 2583628 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 TCGA-DU-8158-01 2194237 2062515 central_nervous_system brain NS NS glioma NS NS NS y COSV51771223 COSM3929114 99381499 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 545 NS NS 57 ENSP00000275493.2:p.Glu84Val ENST00000275493.6:c.251A>T 7:g.55143315A>T EGFR ENST00000275493.6 3633 3236 1001224 1001224 918447 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 GBM9-I2 2813459 2669851 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 P-0005852-T02-IM5 2722238 2581059 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2876606 2876606 2731121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 99392449 c.2374C>T p.L792F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000275493.2:p.Leu792Phe ENST00000275493.6:c.2374C>T 7:g.55181383C>T EGFR ENST00000275493.6 3633 3236 TCGA-DD-A11B-01 2194657 2062935 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51826802 COSM4934162 99380234 c.3251A>G p.D1084G Substitution - Missense 38 7:55202605-55202605 + - PATHOGENIC .91743 Confirmed somatic variant 628 NS NS 73 ENSP00000275493.2:p.Asp1084Gly ENST00000275493.6:c.3251A>G 7:g.55202605A>G EGFR ENST00000275493.6 3633 3236 TCGA-06-0154 2107952 1985813 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 23917401 NS NS ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 TCGA-AA-3811-01 1651034 1565821 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 376 NS NS 84 ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 TCGA-AA-3811-01 1651034 1565821 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51779162 COSM21689 99374883 c.1787C>T p.P596L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 376 NS NS 84 ENSP00000275493.2:p.Pro596Leu ENST00000275493.6:c.1787C>T 7:g.55165344C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_C1 1863682 1754573 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51772009 COSM26704 133208315 c.2105T>C p.L702S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 22975805 surgery fresh/frozen primary 54 ENSP00000415559.1:p.Leu702Ser ENST00000455089.5:c.2105T>C 7:g.55174777T>C EGFR ENST00000275493.6 3633 3236 RS40M 2653649 2513771 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 99373905 c.1562G>A p.R521K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS metastasis 41.32 ENSP00000275493.2:p.Arg521Lys ENST00000275493.6:c.1562G>A 7:g.55161562G>A EGFR ENST00000275493.6 3633 3236 1091697 1091697 1006519 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSM22420 178383004 c.? p.V843I Substitution - Missense + - Confirmed somatic variant 18000506 surgery-fixed NS ENSP00000275493.2:p.Val843Ile EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-GN-A266-06 2121796 1996032 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 133227476 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 540 NS NS 45 ENSP00000415559.1:p.His47Tyr ENST00000455089.5:c.139C>T 7:g.55142336C>T EGFR ENST00000275493.6 3633 3236 1486987 1486987 1410605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777202 COSM20896 99421874 c.2500G>A p.V834M Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 58 ENSP00000275493.2:p.Val834Met ENST00000275493.6:c.2500G>A 7:g.55191749G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 83 898378 815990 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51766331 COSM12366 133243522 c.2437C>A p.L813M Substitution - Missense 38 7:55191821-55191821 + - PATHOGENIC .93782 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Met ENST00000455089.5:c.2437C>A 7:g.55191821C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836288 COSM6348843 133235022 c.2207G>T p.C736F Substitution - Missense 38 7:55181351-55181351 + - PATHOGENIC .98402 Confirmed somatic variant 660 NS primary 46 ENSP00000415559.1:p.Cys736Phe ENST00000455089.5:c.2207G>T 7:g.55181351G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AA-3811-01 1651034 1565821 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 376 NS NS 84 ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0154 2107952 1985813 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 2872355 2872355 2727352 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS n COSV105864558 COSM9946366 99446518 c.3601G>A p.A1201T Substitution - Missense 38 7:55205585-55205585 + - PATHOGENIC .85295 Confirmed somatic variant 31648313 blood-bone marrow recurrent 2.5 ENSP00000275493.2:p.Ala1201Thr ENST00000275493.6:c.3601G>A 7:g.55205585G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003702-T02-IM5 2829639 2685454 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51831642 COSM1496684 133216418 c.853G>A p.E285K Substitution - Missense 38 7:55155928-55155928 + - PATHOGENIC .94538 Confirmed somatic variant 30205045 surgery-fixed metastasis 50 ENSP00000415559.1:p.Glu285Lys ENST00000455089.5:c.853G>A 7:g.55155928G>A EGFR ENST00000275493.6 3633 3236 P-0000686-T01-IM3 2715784 2574605 skin NS NS NS malignant_melanoma NS NS NS n COSV51781503 COSM5608352 99400773 c.1909C>T p.P637S Substitution - Missense het 38 7:55171203-55171203 + - NEUTRAL .1586 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Pro637Ser ENST00000275493.6:c.1909C>T 7:g.55171203C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S04-45633-TP 2366567 2229450 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51801932 COSM4992971 133248115 c.2153C>T p.A718V Substitution - Missense het 38 7:55181297-55181297 + - PATHOGENIC .97799 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000415559.1:p.Ala718Val ENST00000455089.5:c.2153C>T 7:g.55181297C>T EGFR ENST00000275493.6 3633 3236 TCGA-KT-A7W1-01 2262770 2129754 central_nervous_system brain NS NS glioma NS NS NS y COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 545 NS primary 45 ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006402-T01-IM5 2722778 2581599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51772956 COSM13427 133202486 c.1991A>C p.E664A Substitution - Missense het 38 7:55173985-55173985 + - PATHOGENIC .97621 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Glu664Ala ENST00000455089.5:c.1991A>C 7:g.55173985A>C EGFR ENST00000275493.6 3633 3236 T407 2658314 2518473 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51776282 COSM1168015 99373518 c.2258C>T p.P753L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Confirmed somatic variant 27149842 NS NS 69.16 ENSP00000275493.2:p.Pro753Leu ENST00000275493.6:c.2258C>T 7:g.55174795C>T EGFR ENST00000275493.6 3633 3236 982778 982778 898497 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51798694 COSM18419 99453865 c.2200G>A p.E734K Substitution - Missense 38 7:55174737-55174737 + - PATHOGENIC .99879 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Glu734Lys ENST00000275493.6:c.2200G>A 7:g.55174737G>A EGFR ENST00000275493.6 3633 3236 HUB-02-B2-075 2607140 2466852 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51804558 COSM6040422 99436616 c.2379G>T p.M793I Substitution - Missense 38 7:55181388-55181388 + - PATHOGENIC .98402 Confirmed somatic variant 670 organoid culture NS ENSP00000275493.2:p.Met793Ile ENST00000275493.6:c.2379G>T 7:g.55181388G>T EGFR ENST00000275493.6 3633 3236 P-0006876-T01-IM5 2723256 2582077 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 1594195 1594195 1515169 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51786984 COSM133564 99426822 c.3064G>A p.G1022S Substitution - Missense hom 38 7:55201305-55201305 + - PATHOGENIC .97265 Confirmed somatic variant 19726454 surgery fresh/frozen primary 61 ENSP00000275493.2:p.Gly1022Ser ENST00000275493.6:c.3064G>A 7:g.55201305G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 YUMER 2013650 1896282 skin NS NS NS malignant_melanoma NS NS NS y COSV51841339 COSM1698695 133207794 c.1879C>T p.H627Y Substitution - Missense het 38 7:55173077-55173077 + - PATHOGENIC .95363 Confirmed somatic variant 22842228 NS NS ENSP00000415559.1:p.His627Tyr ENST00000455089.5:c.1879C>T 7:g.55173077C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001224 1001224 918447 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006876-T01-IM5 2723256 2582077 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T EGFR ENST00000275493.6 3633 3236 17739 1423845 1333873 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 99375641 c.2497T>G p.L833V Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Leu833Val ENST00000275493.6:c.2497T>G 7:g.55191746T>G EGFR ENST00000275493.6 3633 3236 P-0003068-T01-IM5 2719577 2578398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51843270 COSM6926023 99402285 c.1088C>A p.T363N Substitution - Missense het 38 7:55156614-55156614 + - PATHOGENIC .99429 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr363Asn ENST00000275493.6:c.1088C>A 7:g.55156614C>A EGFR ENST00000275493.6 3633 3236 P-0010107-T01-IM5 2725918 2584739 genital_tract extragonadal soft_tissue NS germ_cell_tumour yolk_sac_tumour NS NS n COSV51834570 COSM6972645 99385417 c.1855C>A p.L619M Substitution - Missense het 38 7:55165412-55165412 + - PATHOGENIC .9982 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu619Met ENST00000275493.6:c.1855C>A 7:g.55165412C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 17739 1423845 1333873 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773059 COSM13424 133203931 c.2362T>G p.L788V Substitution - Missense het 38 7:55191746-55191746 + - NEUTRAL .38826 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Leu788Val ENST00000455089.5:c.2362T>G 7:g.55191746T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876606 2876606 2731121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 133216269 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2254T>A 7:g.55181398T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-HT-8104-01 2194218 2062496 central_nervous_system brain NS NS glioma NS NS NS y COSV51788393 COSM13979 133219516 c.2035G>A p.G679S Substitution - Missense 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 545 NS NS 51 ENSP00000415559.1:p.Gly679Ser ENST00000455089.5:c.2035G>A 7:g.55174029G>A EGFR ENST00000275493.6 3633 3236 TCGA-BT-A42E-01 2193275 2061553 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51814701 COSM7084541 99376045 c.361G>T p.V121F Substitution - Missense 38 7:55143425-55143425 + - PATHOGENIC .99041 Confirmed somatic variant 413 NS NS 74 ENSP00000275493.2:p.Val121Phe ENST00000275493.6:c.361G>T 7:g.55143425G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982782 982782 898501 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003274-T01-IM5 2719770 2578591 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 S_TBL200_R4 2757768 2616342 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29106415 autopsy - NOS metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1460139 1460139 1384016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 99376120 c.2543C>T p.P848L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000275493.2:p.Pro848Leu ENST00000275493.6:c.2543C>T 7:g.55191792C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876606 2876606 2731121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51832101 COSM6493933 133219834 c.2239C>T p.L747F Substitution - Missense 38 7:55181383-55181383 + Yes PATHOGENIC .93168 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000415559.1:p.Leu747Phe ENST00000455089.5:c.2239C>T 7:g.55181383C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-TM-A7C3-01 2262979 2129963 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 43 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 DUMC-22 2748718 2607421 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51771223 COSM3929114 99381499 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 29802247 surgery fresh/frozen NS 62 ENSP00000275493.2:p.Glu84Val ENST00000275493.6:c.251A>T 7:g.55143315A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 77 897189 814812 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51777782 COSM6227 133210005 c.2369A>T p.H790L Substitution - Missense 38 7:55191753-55191753 + - PATHOGENIC .98607 Confirmed somatic variant 15329413 surgery fresh/frozen primary ENSP00000415559.1:p.His790Leu ENST00000455089.5:c.2369A>T 7:g.55191753A>T EGFR ENST00000275493.6 3633 3236 2876063 2876063 2730578 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0002524-T01-IM3 2718790 2577611 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206722 1206722 1118600 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-55-8506-01 2194766 2063044 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 62 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A014-T-S30 2758135 2616706 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CTS177 2393057 2255888 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1468559 1468559 1392310 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206772 1206772 1118650 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001253 1001253 918476 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001826-T01-IM3 2718069 2576890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A028-T-S06 2757394 2615998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460152 1460152 1384029 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876067 2876067 2730582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 75 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152792 2152792 2021802 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206719 1206719 1118597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876064 2876064 2730579 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 R074-I1 2813495 2669887 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99297135 COSM9212199 133222727 c.730G>T p.A244S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 28263318 surgery fresh/frozen NS 41 ENSP00000415559.1:p.Ala244Ser ENST00000455089.5:c.730G>T 7:g.55154128G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Au2 2466841 2329672 skin scalp NS NS malignant_melanoma desmoplastic NS NS y COSV51779748 COSM3639716 133227476 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26343386 surgery fresh/frozen NS 85 ENSP00000415559.1:p.His47Tyr ENST00000455089.5:c.139C>T 7:g.55142336C>T EGFR ENST00000275493.6 3633 3236 P-0004227-T01-IM5 2720634 2579455 pancreas NS NS NS carcinoma acinar_carcinoma NS NS n COSV51849414 COSM6934088 99431419 c.3541G>C p.A1181P Substitution - Missense het 38 7:55205525-55205525 + - PATHOGENIC .73179 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Ala1181Pro ENST00000275493.6:c.3541G>C 7:g.55205525G>C EGFR ENST00000275493.6 3633 3236 CHC892T 2340454 2205437 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51853321 COSM3412170 99414200 c.478G>A p.E160K Substitution - Missense 38 7:55146659-55146659 + - PATHOGENIC .9774 Confirmed somatic variant 381 NS primary 72 ENSP00000275493.2:p.Glu160Lys ENST00000275493.6:c.478G>A 7:g.55146659G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DU-5852-01 2194247 2062525 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 133208833 c.619C>T p.R207C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS NS 61 ENSP00000415559.1:p.Arg207Cys ENST00000455089.5:c.619C>T 7:g.55154017C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-E1-A7YJ-01 2457421 2320258 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 133208833 c.619C>T p.R207C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS primary 55 ENSP00000415559.1:p.Arg207Cys ENST00000455089.5:c.619C>T 7:g.55154017C>T EGFR ENST00000275493.6 3633 3236 S04-45633-TP 2366567 2229450 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51801901 COSM4992959 99423725 c.448T>G p.F150V Substitution - Missense het 38 7:55146629-55146629 + - PATHOGENIC .92059 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000275493.2:p.Phe150Val ENST00000275493.6:c.448T>G 7:g.55146629T>G EGFR ENST00000275493.6 3633 3236 1451167 1451167 1375310 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13173 178378411 c.? p.L861Q Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Leu861Gln EGFR_ENST00000455089 ENST00000455089.5 3276 3236 RS40M 2653649 2513771 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 133202597 c.1427G>A p.R476K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS metastasis 41.32 ENSP00000415559.1:p.Arg476Lys ENST00000455089.5:c.1427G>A 7:g.55161562G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BR-A4QL-01 2197931 2066209 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51771306 COSM1318972 133218950 c.1778C>T p.T593M Substitution - Missense 38 7:55171207-55171207 + - NEUTRAL .03249 Confirmed somatic variant 541 NS NS 75 ENSP00000415559.1:p.Thr593Met ENST00000455089.5:c.1778C>T 7:g.55171207C>T EGFR ENST00000275493.6 3633 3236 2308791 2308791 2173994 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSM4745831 178381722 c.? p.P589L Substitution - Missense + - Confirmed somatic variant 24510240 surgery - NOS NS ENSP00000275493.2:p.Pro589Leu EGFR ENST00000275493.6 3633 3236 P-0000583-T01-IM3 2715566 2574387 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006155-T02-IM5 2722533 2581354 skin NS NS NS malignant_melanoma NS NS NS n COSV51769325 COSM6950792 133254971 c.2948_2949delinsTG p.S983L Substitution - Missense het 38 7:55201324-55201325 + - Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Ser983Leu ENST00000455089.5:c.2948_2949delinsTG 7:g.55201324_55201325delinsTG EGFR ENST00000275493.6 3633 3236 P-0001817-T02-IM5 2719456 2578277 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Sample_1 2367134 2229992 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51788393 COSM13979 133219516 c.2035G>A p.G679S Substitution - Missense hom 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 24894453 NS NS ENSP00000415559.1:p.Gly679Ser ENST00000455089.5:c.2035G>A 7:g.55174029G>A EGFR ENST00000275493.6 3633 3236 3595 915982 833381 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920020 920020 837099 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 72 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982867 982867 898586 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458687 1458687 1382662 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1460155 1460155 1384032 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920024 920024 837103 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152788 2152788 2021798 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 A021-T-S23 2757383 2615995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 57 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206737 1206737 1118615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000370-T01-IM3 2715141 2573962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152793 2152793 2021803 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152776 2152776 2021786 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 60 898380 815992 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876038 2876038 2730553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1460139 1460139 1384016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790305 COSM13194 99378747 c.2540C>T p.T847I Substitution - Missense 38 7:55191789-55191789 + - PATHOGENIC .95119 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000275493.2:p.Thr847Ile ENST00000275493.6:c.2540C>T 7:g.55191789C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 zcc203 2873641 2728634 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS y COSV99297135 COSM9212199 133222727 c.730G>T p.A244S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 33020650 surgery fresh/frozen NS ENSP00000415559.1:p.Ala244Ser ENST00000455089.5:c.730G>T 7:g.55154128G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-HD-7832-01 2193665 2061943 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99286255 COSM8295362 133250359 c.2765A>C p.E922A Substitution - Missense 38 7:55200367-55200367 + - PATHOGENIC .99358 Confirmed somatic variant 627 NS NS 52 ENSP00000415559.1:p.Glu922Ala ENST00000455089.5:c.2765A>C 7:g.55200367A>C EGFR ENST00000275493.6 3633 3236 2901991 2901991 2756229 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM21390 178378619 c.? p.L861R Substitution - Missense + - Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Leu861Arg EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DD-A11B-01 2194657 2062935 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51826802 COSM4934162 133208433 c.3116A>G p.D1039G Substitution - Missense 38 7:55202605-55202605 + - PATHOGENIC .91743 Confirmed somatic variant 628 NS NS 73 ENSP00000415559.1:p.Asp1039Gly ENST00000455089.5:c.3116A>G 7:g.55202605A>G EGFR ENST00000275493.6 3633 3236 P-0010765-T01-IM5 2726446 2585267 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1451167 1451167 1375310 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM13983 178378239 c.? p.G719S Substitution - Missense + - Confirmed somatic variant 20855837 surgery fresh/frozen NS ENSP00000275493.2:p.Gly719Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471565 1471565 1395304 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 TCGA-KT-A7W1-01 2262770 2129754 central_nervous_system brain NS NS glioma NS NS NS y COSV51779524 COSM18425 99379336 c.2156G>A p.G719D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Confirmed somatic variant 545 NS primary 45 ENSP00000275493.2:p.Gly719Asp ENST00000275493.6:c.2156G>A 7:g.55174015G>A EGFR ENST00000275493.6 3633 3236 1043243 1043243 959584 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51779524 COSM18425 99379336 c.2156G>A p.G719D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Confirmed somatic variant 17142003 surgery fresh/frozen primary ENSP00000275493.2:p.Gly719Asp ENST00000275493.6:c.2156G>A 7:g.55174015G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 16784 1423726 1333754 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005464-T01-IM5 2721855 2580676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002861-T01-IM3 2719087 2577908 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1790519 1790519 1693498 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876662 2876662 2731177 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 74 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2811942 2811942 2668490 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed NS 55 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876057 2876057 2730572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 56 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1001224 1001224 918447 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 773 898394 816006 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2591375 2591375 2452335 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM5010368 178378709 c.? p.C797S Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Cys797Ser EGFR ENST00000275493.6 3633 3236 2591485 2591485 2452445 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM86998 178379356 c.? p.R776C Substitution - Missense + - Confirmed somatic variant 27528220 NS recurrent ENSP00000275493.2:p.Arg776Cys EGFR ENST00000275493.6 3633 3236 982786 982786 898505 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1103793 1103793 1018045 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18089646 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 961852 961852 878136 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16467080 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876665 2876665 2731180 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 42 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CT207 2393063 2255894 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 71 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1489243 1489243 1412401 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20881644 surgery fresh/frozen primary 69 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 TCGA-MP-A4SW-01 2194827 2063105 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 417 NS NS 53 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1004987 1004987 922199 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876042 2876042 2730557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 43 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000316-T01-IM3 2715020 2573841 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792237 COSM6842523 133214131 c.694_695delinsGA p.M232E Substitution - Missense het 38 7:55154092-55154093 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Met232Glu ENST00000455089.5:c.694_695delinsGA 7:g.55154092_55154093delinsGA EGFR ENST00000275493.6 3633 3236 CH-LA8 2211434 2079637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24449147 surgery fresh/frozen NS 67 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 982778 982778 898497 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 P-0005435-T01-IM5 2721825 2580646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 T660 2296260 2161863 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51781835 COSM174732 99379122 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 25344691 NS NS 66.58 ENSP00000275493.2:p.Glu114Lys ENST00000275493.6:c.340G>A 7:g.55143404G>A EGFR ENST00000275493.6 3633 3236 P-0010499-T01-IM5 2726216 2585037 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS n COSV51832348 COSM6974705 99420157 c.3602C>T p.A1201V Substitution - Missense het 38 7:55205586-55205586 + - PATHOGENIC .8173 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Ala1201Val ENST00000275493.6:c.3602C>T 7:g.55205586C>T EGFR ENST00000275493.6 3633 3236 TCGA-IQ-7630-01 2193638 2061916 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51792433 COSM6966446 99410412 c.1762G>A p.G588S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 627 NS NS 49 ENSP00000275493.2:p.Gly588Ser ENST00000275493.6:c.1762G>A 7:g.55165319G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206725 1206725 1118603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 4163 915992 833391 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0007236-T01-IM5 2723596 2582417 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920031 920031 837110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 59 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152795 2152795 2021805 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460139 1460139 1384016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 LC_C12 1863693 1754584 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0005553-T01-IM5 2721946 2580767 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2812102 2812102 2668561 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 pleural effusion NS 58 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876042 2876042 2730557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 43 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 TCGA-14-1827-01 2178235 2046533 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99295901 COSM7467664 99433420 c.368C>T p.S123F Substitution - Missense 38 7:55143432-55143432 + - PATHOGENIC .82087 Confirmed somatic variant 329 NS NS 51 ENSP00000275493.2:p.Ser123Phe ENST00000275493.6:c.368C>T 7:g.55143432C>T EGFR ENST00000275493.6 3633 3236 920031 920031 837110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51866622 COSM13426 99442337 c.2512C>G p.L838V Substitution - Missense het 38 7:55191761-55191761 + - PATHOGENIC .89306 Confirmed somatic variant 15623594 surgery fresh/frozen NS 59 ENSP00000275493.2:p.Leu838Val ENST00000275493.6:c.2512C>G 7:g.55191761C>G EGFR ENST00000275493.6 3633 3236 1472951 1472951 1396650 lung NS NS NS carcinoma lymphoepithelioma_like_carcinoma NS NS n COSV51853450 COSM53290 99380220 c.2615A>G p.E872G Substitution - Missense 38 7:55191864-55191864 + - PATHOGENIC .986 Confirmed somatic variant 21070477 surgery-fixed NS ENSP00000275493.2:p.Glu872Gly ENST00000275493.6:c.2615A>G 7:g.55191864A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0650-01 2120258 1994494 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 329 NS NS 39 ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 2876606 2876606 2731121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 99388191 c.2389T>A p.C797S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2389T>A 7:g.55181398T>A EGFR ENST00000275493.6 3633 3236 pfg068T 2309636 2174838 stomach NS NS NS carcinoma intestinal_adenocarcinoma NS NS y COSV51767379 COSM85894 99384993 c.2527G>A p.V843I Substitution - Missense het 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 24816253 surgery fresh/frozen NS 74 ENSP00000275493.2:p.Val843Ile ENST00000275493.6:c.2527G>A 7:g.55191776G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003169-T01-IM5 2719662 2578483 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR ENST00000275493.6 3633 3236 TCGA-AA-A00N-01 1651102 1565889 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51852585 COSM274945 99387381 c.926G>A p.R309Q Substitution - Missense 38 7:55155866-55155866 + - PATHOGENIC .98601 Confirmed somatic variant 22810696 376 NS NS 75 ENSP00000275493.2:p.Arg309Gln ENST00000275493.6:c.926G>A 7:g.55155866G>A EGFR ENST00000275493.6 3633 3236 A102-T-S04 2757412 2616002 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 73 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1004985 1004985 922197 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0011308-T01-IM5 2726911 2585732 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0012083-T01-IM5 2727225 2586046 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876606 2876606 2731121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105111204 COSM9926231 99458168 c.2380C>T p.P794S Substitution - Missense 38 7:55181389-55181389 + - PATHOGENIC .97194 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000275493.2:p.Pro794Ser ENST00000275493.6:c.2380C>T 7:g.55181389C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010107-T01-IM5 2725918 2584739 genital_tract extragonadal soft_tissue NS germ_cell_tumour yolk_sac_tumour NS NS n COSV51834570 COSM6972645 133213901 c.1720C>A p.L574M Substitution - Missense het 38 7:55165412-55165412 + - PATHOGENIC .9982 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu574Met ENST00000455089.5:c.1720C>A 7:g.55165412C>A EGFR ENST00000275493.6 3633 3236 TCGA-TQ-A7RP-01 2457441 2320278 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 99380629 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS primary 66 ENSP00000275493.2:p.Arg252Cys ENST00000275493.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AR-A0TV-01 1779493 1683492 breast NS NS NS carcinoma NS NS NS y COSV99293406 COSM7679798 133242228 c.1442G>C p.C481S Substitution - Missense 38 7:55161577-55161577 + - PATHOGENIC .9951 Confirmed somatic variant 414 fresh/frozen - NOS primary 66 ENSP00000415559.1:p.Cys481Ser ENST00000455089.5:c.1442G>C 7:g.55161577G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000686-T01-IM3 2715784 2574605 skin NS NS NS malignant_melanoma NS NS NS n COSV51781521 COSM6912042 133258793 c.2920C>T p.P974S Substitution - Missense het 38 7:55201296-55201296 + - PATHOGENIC .99234 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Pro974Ser ENST00000455089.5:c.2920C>T 7:g.55201296C>T EGFR ENST00000275493.6 3633 3236 1468558 1468558 1392309 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM13448 178378160 c.? p.G719A Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Gly719Ala EGFR ENST00000275493.6 3633 3236 P-0013010-T01-IM5 2803821 2660571 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51866279 COSM6926300 99378313 c.665G>A p.R222H Substitution - Missense het 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 29316426 surgery-fixed primary 64 ENSP00000275493.2:p.Arg222His ENST00000275493.6:c.665G>A 7:g.55152582G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 MM18T 2457741 2320578 endometrium NS NS NS carcinoma carcinosarcoma-malignant_mesodermal_mixed_tumour NS NS n COSV51810684 COSM5415932 133218492 c.2854T>G p.F952V Substitution - Missense 38 7:55201230-55201230 + - PATHOGENIC .9773 Confirmed somatic variant 25233892 surgery-fixed primary 59 ENSP00000415559.1:p.Phe952Val ENST00000455089.5:c.2854T>G 7:g.55201230T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM9-I2 2813459 2669851 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005303-T01-IM5 2721704 2580525 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51769031 COSM21690 133202050 c.1658G>T p.G553V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Gly553Val ENST00000455089.5:c.1658G>T 7:g.55165350G>T EGFR ENST00000275493.6 3633 3236 P-0009272-T01-IM5 2725229 2584050 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51806679 COSM6967939 99433149 c.3280A>T p.N1094Y Substitution - Missense het 38 7:55205264-55205264 + - PATHOGENIC .98082 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Asn1094Tyr ENST00000275493.6:c.3280A>T 7:g.55205264A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000400-T01-IM3 2715204 2574025 urinary_tract urethra NS NS carcinoma adenocarcinoma NS NS n COSV51859563 COSM6910210 133204470 c.2374G>A p.D792N Substitution - Missense het 38 7:55191758-55191758 + - PATHOGENIC .98912 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Asp792Asn ENST00000455089.5:c.2374G>A 7:g.55191758G>A EGFR ENST00000275493.6 3633 3236 2675082 2675082 2534357 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 29110836 surgery-fixed recurrent 69 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 5-VS094-T1 2869927 2724924 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51776578 COSM4893368 99381173 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 26950094 surgery - NOS NS 84 ENSP00000275493.2:p.Ser116Phe ENST00000275493.6:c.347C>T 7:g.55143411C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 EOPC-126_tumor_01 2633717 2494113 prostate NS NS NS carcinoma NS NS NS y COSV51793336 COSM6214981 133241745 c.1528T>C p.C510R Substitution - Missense 38 7:55163764-55163764 + - PATHOGENIC .99407 Confirmed somatic variant 534 NS primary 47 ENSP00000415559.1:p.Cys510Arg ENST00000455089.5:c.1528T>C 7:g.55163764T>C EGFR ENST00000275493.6 3633 3236 1483443 1483443 1407069 upper_aerodigestive_tract head_neck NS NS carcinoma NS NS NS n COSV51767379 COSM85894 99384993 c.2527G>A p.V843I Substitution - Missense het 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 21274259 surgery-fixed NS 72 ENSP00000275493.2:p.Val843Ile ENST00000275493.6:c.2527G>A 7:g.55191776G>A EGFR ENST00000275493.6 3633 3236 A001-T-S04 2757357 2615991 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 17739 1423845 1333873 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-BT-A42E-01 2193275 2061553 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51814701 COSM7084541 133204290 c.361G>T p.V121F Substitution - Missense 38 7:55143425-55143425 + - PATHOGENIC .99041 Confirmed somatic variant 413 NS NS 74 ENSP00000415559.1:p.Val121Phe ENST00000455089.5:c.361G>T 7:g.55143425G>T EGFR ENST00000275493.6 3633 3236 2696711 2696711 2555615 oesophagus upper_third NS NS other metaplasia epidermoid NS n COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28731047 surgery-fixed primary 62 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 pfg068T 2309636 2174838 stomach NS NS NS carcinoma intestinal_adenocarcinoma NS NS y COSV51767379 COSM85894 133213549 c.2392G>A p.V798I Substitution - Missense het 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 24816253 surgery fresh/frozen NS 74 ENSP00000415559.1:p.Val798Ile ENST00000455089.5:c.2392G>A 7:g.55191776G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001817-T02-IM5 2719456 2578277 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2115518 2115518 1989762 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1468651 1468651 1392402 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 2876606 2876606 2731121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2156364 2156364 2025373 lung right_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 24752053 surgery - NOS primary 48 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460139 1460139 1384016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51773049 COSM22943 133204348 c.2408C>T p.P803L Substitution - Missense 38 7:55191792-55191792 + - PATHOGENIC .9788 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000415559.1:p.Pro803Leu ENST00000455089.5:c.2408C>T 7:g.55191792C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-NB016-T1 2869816 2724813 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV51776967 COSM6963220 133218398 c.1795C>T p.P599S Substitution - Missense 38 7:55172993-55172993 + - PATHOGENIC .96242 Confirmed somatic variant 26950094 surgery fresh/frozen NS 74 ENSP00000415559.1:p.Pro599Ser ENST00000455089.5:c.1795C>T 7:g.55172993C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD42098a 2894843 2749331 skin trunk NS NS malignant_melanoma nodular NS NS y COSV51776967 COSM6963220 133218398 c.1795C>T p.P599S Substitution - Missense 38 7:55172993-55172993 + - PATHOGENIC .96242 Confirmed somatic variant 33024263 surgery-fixed metastasis 42 ENSP00000415559.1:p.Pro599Ser ENST00000455089.5:c.1795C>T 7:g.55172993C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CHG-14-15016T 2634332 2494728 liver NS NS NS other neoplasm NS NS y COSV51830076 COSM6272360 133238992 c.3144G>T p.W1048C Substitution - Missense 38 7:55202633-55202633 + - NEUTRAL .09476 Confirmed somatic variant 660 NS primary 70 ENSP00000415559.1:p.Trp1048Cys ENST00000455089.5:c.3144G>T 7:g.55202633G>T EGFR ENST00000275493.6 3633 3236 P-0000686-T01-IM3 2715784 2574605 skin NS NS NS malignant_melanoma NS NS NS n COSV51781521 COSM6912042 99435886 c.3055C>T p.P1019S Substitution - Missense het 38 7:55201296-55201296 + - PATHOGENIC .99234 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Pro1019Ser ENST00000275493.6:c.3055C>T 7:g.55201296C>T EGFR ENST00000275493.6 3633 3236 LC_C1 1863682 1754573 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51772009 COSM26704 99380127 c.2240T>C p.L747S Substitution - Missense 38 7:55174777-55174777 + - PATHOGENIC .99058 Confirmed somatic variant 22975805 surgery fresh/frozen primary 54 ENSP00000275493.2:p.Leu747Ser ENST00000275493.6:c.2240T>C 7:g.55174777T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T407 2658314 2518473 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51776282 COSM1168015 133202278 c.2123C>T p.P708L Substitution - Missense 38 7:55174795-55174795 + - PATHOGENIC .98745 Confirmed somatic variant 27149842 NS NS 69.16 ENSP00000415559.1:p.Pro708Leu ENST00000455089.5:c.2123C>T 7:g.55174795C>T EGFR ENST00000275493.6 3633 3236 2876649 2876649 2731164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105111022 COSM9869939 99457336 c.2275A>C p.I759L Substitution - Missense 38 7:55174812-55174812 + - PATHOGENIC .99492 Confirmed somatic variant 29506987 circulating tumour NS 48 ENSP00000275493.2:p.Ile759Leu ENST00000275493.6:c.2275A>C 7:g.55174812A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AA-3811-01 1651034 1565821 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51779162 COSM21689 133203297 c.1652C>T p.P551L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 376 NS NS 84 ENSP00000415559.1:p.Pro551Leu ENST00000455089.5:c.1652C>T 7:g.55165344C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 HUB-02-B2-075 2607140 2466852 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51804558 COSM6040422 133259522 c.2244G>T p.M748I Substitution - Missense 38 7:55181388-55181388 + - PATHOGENIC .98402 Confirmed somatic variant 670 organoid culture NS ENSP00000415559.1:p.Met748Ile ENST00000455089.5:c.2244G>T 7:g.55181388G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 17218 1423801 1333829 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51785911 COSM48912 133273147 c.1216_1217delinsTT p.R406F Substitution - Missense het 38 7:55160191-55160192 + - Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000415559.1:p.Arg406Phe ENST00000455089.5:c.1216_1217delinsTT 7:g.55160191_55160192delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 5-VS094-T1 2869927 2724924 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51776578 COSM4893368 133209492 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 26950094 surgery - NOS NS 84 ENSP00000415559.1:p.Ser116Phe ENST00000455089.5:c.347C>T 7:g.55143411C>T EGFR ENST00000275493.6 3633 3236 86770 1520642 1443017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51850613 COSM94183 99440953 c.2270A>T p.K757M Substitution - Missense 38 7:55174807-55174807 + - PATHOGENIC .99468 Confirmed somatic variant 20668451 NS primary ENSP00000275493.2:p.Lys757Met ENST00000275493.6:c.2270A>T 7:g.55174807A>T EGFR ENST00000275493.6 3633 3236 TCGA-HT-8104-01 2194218 2062496 central_nervous_system brain NS NS glioma NS NS NS y COSV51788393 COSM13979 99391974 c.2170G>A p.G724S Substitution - Missense 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 545 NS NS 51 ENSP00000275493.2:p.Gly724Ser ENST00000275493.6:c.2170G>A 7:g.55174029G>A EGFR ENST00000275493.6 3633 3236 920041 920041 837120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 99379162 c.2303G>T p.S768I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 15623594 surgery fresh/frozen NS 75 ENSP00000275493.2:p.Ser768Ile ENST00000275493.6:c.2303G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 1468559 1468559 1392310 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM53177 178381723 c.? p.G779C Substitution - Missense + - Confirmed somatic variant 21030498 surgery - NOS NS ENSP00000275493.2:p.Gly779Cys EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1005022 1005022 922234 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51766618 COSM12374 133206840 c.2447T>G p.L816R Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .98181 Confirmed somatic variant 16863509 surgery fresh/frozen primary ENSP00000415559.1:p.Leu816Arg ENST00000455089.5:c.2447T>G 7:g.55191831T>G EGFR ENST00000275493.6 3633 3236 P-0001826-T01-IM3 2718069 2576890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206772 1206772 1118650 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1001253 1001253 918476 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206719 1206719 1118597 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876067 2876067 2730582 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A028-T-S06 2757394 2615998 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 75 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152792 2152792 2021802 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876064 2876064 2730579 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour recurrent 58 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1460152 1460152 1384029 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010765-T01-IM5 2726446 2585267 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 R074-I1 2813495 2669887 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 41 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-DU-8158-01 2194237 2062515 central_nervous_system brain NS NS glioma NS NS NS y COSV51771223 COSM3929114 133209833 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 545 NS NS 57 ENSP00000415559.1:p.Glu84Val ENST00000455089.5:c.251A>T 7:g.55143315A>T EGFR ENST00000275493.6 3633 3236 P-0001826-T01-IM3 2718069 2576890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594193 1594193 1515167 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51804843 COSM12429 133209145 c.2438_2439delinsGT p.L813R Substitution - Missense het 38 7:55191822-55191823 + - Confirmed somatic variant 19726454 surgery fresh/frozen primary 58 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438_2439delinsGT 7:g.55191822_55191823delinsGT EGFR ENST00000275493.6 3633 3236 EOPC-126_tumor_01 2633717 2494113 prostate NS NS NS carcinoma NS NS NS y COSV51793336 COSM6214981 99416047 c.1663T>C p.C555R Substitution - Missense 38 7:55163764-55163764 + - PATHOGENIC .99407 Confirmed somatic variant 534 NS primary 47 ENSP00000275493.2:p.Cys555Arg ENST00000275493.6:c.1663T>C 7:g.55163764T>C EGFR ENST00000275493.6 3633 3236 17218 1423801 1333829 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51785911 COSM48912 99450018 c.1351_1352delinsTT p.R451F Substitution - Missense het 38 7:55160191-55160192 + - Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Arg451Phe ENST00000275493.6:c.1351_1352delinsTT 7:g.55160191_55160192delinsTT EGFR ENST00000275493.6 3633 3236 TCGA-VQ-A8P5-01 2339762 2204745 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51780766 COSM219795 99373292 c.2591C>T p.A864V Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .93098 Confirmed somatic variant 541 NS primary 67 ENSP00000275493.2:p.Ala864Val ENST00000275493.6:c.2591C>T 7:g.55191840C>T EGFR ENST00000275493.6 3633 3236 Sample_1 2367134 2229992 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51788393 COSM13979 99391974 c.2170G>A p.G724S Substitution - Missense hom 38 7:55174029-55174029 + - PATHOGENIC .98273 Confirmed somatic variant 24894453 NS NS ENSP00000275493.2:p.Gly724Ser ENST00000275493.6:c.2170G>A 7:g.55174029G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005553-T01-IM5 2721946 2580767 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2812102 2812102 2668561 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 31534501 pleural effusion NS 58 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876042 2876042 2730557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 43 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P121 2072581 1951936 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51785554 COSM21688 99375522 c.971G>T p.R324L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 57.59 ENSP00000275493.2:p.Arg324Leu ENST00000275493.6:c.971G>T 7:g.55155911G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM18-I1 2813453 2669845 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769451 COSM26036 133262088 c.2471A>G p.Y824C Substitution - Missense 38 7:55191855-55191855 + - PATHOGENIC .986 Confirmed somatic variant 28263318 surgery fresh/frozen NS 40 ENSP00000415559.1:p.Tyr824Cys ENST00000455089.5:c.2471A>G 7:g.55191855A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1483443 1483443 1407069 upper_aerodigestive_tract head_neck NS NS carcinoma NS NS NS n COSV51767379 COSM85894 133213549 c.2392G>A p.V798I Substitution - Missense het 38 7:55191776-55191776 + - PATHOGENIC .98912 Confirmed somatic variant 21274259 surgery-fixed NS 72 ENSP00000415559.1:p.Val798Ile ENST00000455089.5:c.2392G>A 7:g.55191776G>A EGFR ENST00000275493.6 3633 3236 PD42095c 2894834 2749322 skin extremity NS NS malignant_melanoma in_situ_melanotic_neoplasm NS NS y COSV51767260 COSM12988 99373551 c.2125G>A p.E709K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 33024263 surgery-fixed metastasis 56 ENSP00000275493.2:p.Glu709Lys ENST00000275493.6:c.2125G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0013010-T01-IM5 2803821 2660571 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51866279 COSM6926300 133206418 c.530G>A p.R177H Substitution - Missense het 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 29316426 surgery-fixed primary 64 ENSP00000415559.1:p.Arg177His ENST00000455089.5:c.530G>A 7:g.55152582G>A EGFR ENST00000275493.6 3633 3236 P-0000370-T01-IM3 2715141 2573962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51849071 COSM6910043 99446268 c.831_832delinsTT p.M277_D278delinsIY Substitution - Missense het 38 7:55154094-55154095 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Met277_Asp278delinsIleTyr ENST00000275493.6:c.831_832delinsTT 7:g.55154094_55154095delinsTT EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1505360 1505360 1428238 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV51802570 COSM87245 133245317 c.2096T>C p.I699T Substitution - Missense 38 7:55174768-55174768 + - PATHOGENIC .99336 Confirmed somatic variant 21409490 surgery-fixed NS ENSP00000415559.1:p.Ile699Thr ENST00000455089.5:c.2096T>C 7:g.55174768T>C EGFR ENST00000275493.6 3633 3236 P-0006155-T02-IM5 2722533 2581354 skin NS NS NS malignant_melanoma NS NS NS n COSV51769325 COSM6950792 99431426 c.3083_3084delinsTG p.S1028L Substitution - Missense het 38 7:55201324-55201325 + - Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Ser1028Leu ENST00000275493.6:c.3083_3084delinsTG 7:g.55201324_55201325delinsTG EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BC85-ctDNA 2668219 2527792 breast NS NS NS carcinoma NS NS NS y COSV51834499 COSM6845063 133203949 c.829G>A p.G277S Substitution - Missense het 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 27535334 circulating tumour metastasis ENSP00000415559.1:p.Gly277Ser ENST00000455089.5:c.829G>A 7:g.55155904G>A EGFR ENST00000275493.6 3633 3236 1486993 1486993 1410611 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51789362 COSM13184 99406147 c.2236G>A p.E746K Substitution - Missense 38 7:55174773-55174773 + - PATHOGENIC .99624 Confirmed somatic variant 16567021 surgery-fixed primary 44 ENSP00000275493.2:p.Glu746Lys ENST00000275493.6:c.2236G>A 7:g.55174773G>A EGFR ENST00000275493.6 3633 3236 920041 920041 837120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 99374078 c.2155G>T p.G719C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15623594 surgery fresh/frozen NS 75 ENSP00000275493.2:p.Gly719Cys ENST00000275493.6:c.2155G>T 7:g.55174014G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-CD-A4MG-01 2198123 2066401 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51852047 COSM3881818 133220970 c.1154C>T p.T385I Substitution - Missense 38 7:55157744-55157744 + - PATHOGENIC .99429 Confirmed somatic variant 541 NS NS 76 ENSP00000415559.1:p.Thr385Ile ENST00000455089.5:c.1154C>T 7:g.55157744C>T EGFR ENST00000275493.6 3633 3236 P-0005464-T01-IM5 2721855 2580676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2811942 2811942 2668490 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 31534501 surgery-fixed NS 55 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876662 2876662 2731177 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 74 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1790519 1790519 1693498 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1001224 1001224 918447 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15998907 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0002861-T01-IM3 2719087 2577908 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876057 2876057 2730572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS recurrent 56 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 16784 1423726 1333754 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 773 898394 816006 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-26-5139-01 2120327 1994563 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51856614 COSM3412172 133257200 c.533G>A p.C178Y Substitution - Missense 38 7:55152585-55152585 + - PATHOGENIC .99676 Confirmed somatic variant 329 NS NS 65 ENSP00000415559.1:p.Cys178Tyr ENST00000455089.5:c.533G>A 7:g.55152585G>A EGFR ENST00000275493.6 3633 3236 2864407 2864407 2719565 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM5010368 178378709 c.? p.C797S Substitution - Missense + Yes Confirmed somatic variant 31761448 circulating tumour recurrent 63 ENSP00000275493.2:p.Cys797Ser EGFR ENST00000275493.6 3633 3236 2901991 2901991 2756229 lung left_lower_lobe NS NS carcinoma adenocarcinoma NS NS n COSM5010368 178378709 c.? p.C797S Substitution - Missense + Yes Confirmed somatic variant 32777674 surgery-fixed primary 60 ENSP00000275493.2:p.Cys797Ser EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-KT-A7W1-01 2262770 2129754 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 45 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 zcc203 2873641 2728634 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 33020650 surgery fresh/frozen NS ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 P-0005464-T01-IM5 2721855 2580676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876057 2876057 2730572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 56 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1211131 1211131 1122999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen metastasis 45 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-KT-A7W1-01 2262770 2129754 central_nervous_system brain NS NS glioma NS NS NS y COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 545 NS primary 45 ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR ENST00000275493.6 3633 3236 P-0010053-T01-IM5 2725865 2584686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 99375984 c.2582T>A p.L861Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu861Gln ENST00000275493.6:c.2582T>A 7:g.55191831T>A EGFR ENST00000275493.6 3633 3236 TCGA-A8-A094-01 1779383 1683382 breast NS NS NS carcinoma NS NS NS y COSV51768800 COSM6499385 99400008 c.844G>A p.E282K Substitution - Missense 38 7:55154107-55154107 + - PATHOGENIC .81806 Confirmed somatic variant 414 fresh/frozen - NOS primary 75 ENSP00000275493.2:p.Glu282Lys ENST00000275493.6:c.844G>A 7:g.55154107G>A EGFR ENST00000275493.6 3633 3236 2862278 2862278 2717468 lung NS NS NS carcinoma pleomorphic_carcinoma NS NS n COSV105110411 COSM9581267 99377866 c.3437G>C p.C1146S Substitution - Missense 38 7:55205421-55205421 + - NEUTRAL .16376 Confirmed somatic variant 32578376 surgery fresh/frozen primary 69 ENSP00000275493.2:p.Cys1146Ser ENST00000275493.6:c.3437G>C 7:g.55205421G>C EGFR ENST00000275493.6 3633 3236 1206737 1206737 1118615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 60 898380 815992 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15681531 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152788 2152788 2021798 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0000370-T01-IM3 2715141 2573962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920024 920024 837103 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152776 2152776 2021786 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876038 2876038 2730553 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152793 2152793 2021803 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 A021-T-S23 2757383 2615995 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29335443 surgery fresh/frozen primary 57 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206737 1206737 1118615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0000583-T01-IM3 2715566 2574387 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 GBM18-I1 2813453 2669845 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769451 COSM26036 99439084 c.2606A>G p.Y869C Substitution - Missense 38 7:55191855-55191855 + - PATHOGENIC .986 Confirmed somatic variant 28263318 surgery fresh/frozen NS 40 ENSP00000275493.2:p.Tyr869Cys ENST00000275493.6:c.2606A>G 7:g.55191855A>G EGFR ENST00000275493.6 3633 3236 4163 915992 833391 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16014883 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920031 920031 837110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 59 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1206725 1206725 1118603 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 LC_C12 1863693 1754584 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 22975805 surgery fresh/frozen primary 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0007236-T01-IM5 2723596 2582417 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152795 2152795 2021805 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1460139 1460139 1384016 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20811949 surgery-fixed metastasis ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-TQ-A7RP-01 2457441 2320278 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 133208833 c.619C>T p.R207C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS primary 66 ENSP00000415559.1:p.Arg207Cys ENST00000455089.5:c.619C>T 7:g.55154017C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1594195 1594195 1515169 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51786984 COSM133564 133250445 c.2929G>A p.G977S Substitution - Missense hom 38 7:55201305-55201305 + - PATHOGENIC .97265 Confirmed somatic variant 19726454 surgery fresh/frozen primary 61 ENSP00000415559.1:p.Gly977Ser ENST00000455089.5:c.2929G>A 7:g.55201305G>A EGFR ENST00000275493.6 3633 3236 P-0009535-T01-IM5 2725452 2584273 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0003170-T01-IM5 2719663 2578484 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51841905 COSM6926730 99377591 c.931T>C p.C311R Substitution - Missense het 38 7:55155871-55155871 + - PATHOGENIC .98694 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Cys311Arg ENST00000275493.6:c.931T>C 7:g.55155871T>C EGFR ENST00000275493.6 3633 3236 2675080 2675080 2534355 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 29110836 surgery-fixed recurrent 72 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 F1410200833 2861655 2716875 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + - Confirmed somatic variant 27247954 surgery-fixed NS 52 ENSP00000275493.2:p.Thr790Met EGFR ENST00000275493.6 3633 3236 2675066 2675066 2534341 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSM21943 178378161 c.? p.T790M Substitution - Missense + Yes Confirmed somatic variant 29110836 surgery-fixed recurrent 50 ENSP00000275493.2:p.Thr790Met EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GBM9-I2 2813459 2669851 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005852-T02-IM5 2722238 2581059 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 DUMC-22 2748718 2607421 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51771223 COSM3929114 133209833 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 29802247 surgery fresh/frozen NS 62 ENSP00000415559.1:p.Glu84Val ENST00000455089.5:c.251A>T 7:g.55143315A>T EGFR ENST00000275493.6 3633 3236 T116 2658237 2518396 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51773524 COSM1090858 99375990 c.418T>G p.L140V Substitution - Missense 38 7:55143482-55143482 + - NEUTRAL .25717 Confirmed somatic variant 27149842 NS NS 52.58 ENSP00000275493.2:p.Leu140Val ENST00000275493.6:c.418T>G 7:g.55143482T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920031 920031 837110 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51866622 COSM13426 133265612 c.2377C>G p.L793V Substitution - Missense het 38 7:55191761-55191761 + - PATHOGENIC .89306 Confirmed somatic variant 15623594 surgery fresh/frozen NS 59 ENSP00000415559.1:p.Leu793Val ENST00000455089.5:c.2377C>G 7:g.55191761C>G EGFR ENST00000275493.6 3633 3236 2115512 2115512 1989756 lung NS NS NS carcinoma adenocarcinoma NS NS n COSM12979 178378159 c.? p.L858R Substitution - Missense + - Confirmed somatic variant 23919423 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg EGFR ENST00000275493.6 3633 3236 1040346 1040346 956923 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_II NS NS n COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000370-T01-IM3 2715141 2573962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51849071 COSM6910043 133269676 c.696_697delinsTT p.M232_D233delinsIY Substitution - Missense het 38 7:55154094-55154095 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Met232_Asp233delinsIleTyr ENST00000455089.5:c.696_697delinsTT 7:g.55154094_55154095delinsTT EGFR ENST00000275493.6 3633 3236 s_IG_thy_023_P 2760359 2618892 thyroid NS NS NS carcinoma NS NS NS n COSV51860085 COSM7339210 99426269 c.3502G>T p.D1168Y Substitution - Missense 38 7:55205486-55205486 + - PATHOGENIC .97405 Confirmed somatic variant 28634282 surgery-fixed primary ENSP00000275493.2:p.Asp1168Tyr ENST00000275493.6:c.3502G>T 7:g.55205486G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920041 920041 837120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766606 COSM6253 133202732 c.2020G>T p.G674C Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97663 Confirmed somatic variant 15623594 surgery fresh/frozen NS 75 ENSP00000415559.1:p.Gly674Cys ENST00000455089.5:c.2020G>T 7:g.55174014G>T EGFR ENST00000275493.6 3633 3236 BK0004 2237563 2105067 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51826868 COSM4185521 99422323 c.2640G>T p.W880C Substitution - Missense 38 7:55192780-55192780 + - PATHOGENIC .96888 Confirmed somatic variant 24504440 surgery - NOS NS ENSP00000275493.2:p.Trp880Cys ENST00000275493.6:c.2640G>T 7:g.55192780G>T EGFR ENST00000275493.6 3633 3236 TCGA-4W-AA9T-01 2339571 2204554 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 99377812 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS primary 54 ENSP00000275493.2:p.Ala289Val ENST00000275493.6:c.866C>T 7:g.55154129C>T EGFR ENST00000275493.6 3633 3236 2876603 2876603 2731118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 99388191 c.2389T>A p.C797S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 60 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2389T>A 7:g.55181398T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P121 2072581 1951936 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51785554 COSM21688 133203816 c.836G>T p.R279L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 57.59 ENSP00000415559.1:p.Arg279Leu ENST00000455089.5:c.836G>T 7:g.55155911G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0650-01 2120258 1994494 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779524 COSM18425 133207486 c.2021G>A p.G674D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Confirmed somatic variant 329 NS NS 39 ENSP00000415559.1:p.Gly674Asp ENST00000455089.5:c.2021G>A 7:g.55174015G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0006402-T01-IM5 2722778 2581599 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767289 COSM6252 133202308 c.2020G>A p.G674S Substitution - Missense het 38 7:55174014-55174014 + - PATHOGENIC .97363 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Gly674Ser ENST00000455089.5:c.2020G>A 7:g.55174014G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920041 920041 837120 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51768106 COSM6241 133207299 c.2168G>T p.S723I Substitution - Missense het 38 7:55181312-55181312 + - PATHOGENIC .98684 Confirmed somatic variant 15623594 surgery fresh/frozen NS 75 ENSP00000415559.1:p.Ser723Ile ENST00000455089.5:c.2168G>T 7:g.55181312G>T EGFR ENST00000275493.6 3633 3236 GB052T 2634017 2494413 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 99374391 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 672 NS primary ENSP00000275493.2:p.Arg222Cys ENST00000275493.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1460124 1460124 1384001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51770762 COSM52933 133264116 c.2396T>C p.L799P Substitution - Missense 38 7:55191780-55191780 + - PATHOGENIC .97813 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000415559.1:p.Leu799Pro ENST00000455089.5:c.2396T>C 7:g.55191780T>C EGFR ENST00000275493.6 3633 3236 982882 982882 898601 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1790520 1790520 1693499 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CTS149 2393053 2255884 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 66 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471543 1471543 1395282 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 PM02T 2653317 2513444 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS primary 75.8 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1471533 1471533 1395272 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 1458693 1458693 1382668 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876603 2876603 2731118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 60 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0237 2107974 1985835 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 23917401 NS NS ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2156364 2156364 2025373 lung right_upper_lobe NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 24752053 surgery - NOS primary 48 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876606 2876606 2731121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 52 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CHG-13-09220T 2634310 2494706 liver NS NS NS other neoplasm NS NS y COSV51802176 COSM6258054 133280902 c.111G>T p.K37N Substitution - Missense 38 7:55142308-55142308 + - PATHOGENIC .84286 Confirmed somatic variant 660 NS primary 67 ENSP00000415559.1:p.Lys37Asn ENST00000455089.5:c.111G>T 7:g.55142308G>T EGFR ENST00000275493.6 3633 3236 2876048 2876048 2730563 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 44 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876626 2876626 2731141 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 69 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1211143 1211143 1123011 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 50 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876603 2876603 2731118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 60 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 1211144 1211144 1123012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen metastasis 70 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 P-0000681-T02-IM5 2719371 2578192 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 99374552 c.2156G>C p.G719A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000275493.2:p.Gly719Ala ENST00000275493.6:c.2156G>C 7:g.55174015G>C EGFR ENST00000275493.6 3633 3236 1486996 1486996 1410614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51811013 COSM85960 99455021 c.2261A>G p.K754R Substitution - Missense 38 7:55174798-55174798 + - PATHOGENIC .9918 Confirmed somatic variant 16567021 surgery-fixed primary 68 ENSP00000275493.2:p.Lys754Arg ENST00000275493.6:c.2261A>G 7:g.55174798A>G EGFR ENST00000275493.6 3633 3236 1460124 1460124 1384001 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51770762 COSM52933 99440923 c.2531T>C p.L844P Substitution - Missense 38 7:55191780-55191780 + - PATHOGENIC .97813 Confirmed somatic variant 20811949 surgery-fixed primary ENSP00000275493.2:p.Leu844Pro ENST00000275493.6:c.2531T>C 7:g.55191780T>C EGFR ENST00000275493.6 3633 3236 P-0012194-T01-IM5 2727317 2586138 skin NS NS NS malignant_melanoma NS NS NS n COSV51860991 COSM6983544 99383056 c.97_98delinsAA p.G33N Substitution - Missense het 38 7:55142294-55142295 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Gly33Asn ENST00000275493.6:c.97_98delinsAA 7:g.55142294_55142295delinsAA EGFR ENST00000275493.6 3633 3236 RK308_C01 2194686 2062964 liver NS NS NS carcinoma NS NS NS y COSV51780206 COSM12373 99380273 c.2159C>T p.S720F Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .9768 Confirmed somatic variant 322 NS NS ENSP00000275493.2:p.Ser720Phe ENST00000275493.6:c.2159C>T 7:g.55174018C>T EGFR ENST00000275493.6 3633 3236 TCGA-A7-A6VX-01 2262909 2129893 breast NS NS NS carcinoma NS NS NS y COSV99294439 COSM7672524 99400954 c.439G>A p.A147T Substitution - Missense 38 7:55146620-55146620 + - PATHOGENIC .9897 Confirmed somatic variant 414 NS primary 68 ENSP00000275493.2:p.Ala147Thr ENST00000275493.6:c.439G>A 7:g.55146620G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0004666-T01-IM5 2721066 2579887 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 133216074 c.1339A>C p.S447R Substitution - Missense het 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Ser447Arg ENST00000455089.5:c.1339A>C 7:g.55160314A>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2492700 2492700 2355315 skin face NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 133227476 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen primary ENSP00000415559.1:p.His47Tyr ENST00000455089.5:c.139C>T 7:g.55142336C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2696711 2696711 2555615 oesophagus upper_third NS NS other metaplasia epidermoid NS n COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28731047 surgery-fixed primary 62 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 TCGA-06-0878-01 1337866 1248251 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 99373476 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 74 ENSP00000275493.2:p.Ala289Thr ENST00000275493.6:c.865G>A 7:g.55154128G>A EGFR ENST00000275493.6 3633 3236 P-0005943-T01-IM5 2722326 2581147 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51829196 COSM6947106 99389909 c.3203G>A p.R1068Q Substitution - Missense het 38 7:55202557-55202557 + - PATHOGENIC .97786 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000275493.2:p.Arg1068Gln ENST00000275493.6:c.3203G>A 7:g.55202557G>A EGFR ENST00000275493.6 3633 3236 T116 2658237 2518396 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51787894 COSM6652229 99413090 c.84G>T p.K28N Substitution - Missense 38 7:55019361-55019361 + - NEUTRAL .32765 Confirmed somatic variant 27149842 NS NS 52.58 ENSP00000275493.2:p.Lys28Asn ENST00000275493.6:c.84G>T 7:g.55019361G>T EGFR ENST00000275493.6 3633 3236 PD5757a 1465371 1389218 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51785945 COSM4384127 99433192 c.2726C>G p.T909S Substitution - Missense 38 7:55198741-55198741 + - PATHOGENIC .992 Confirmed somatic variant 24030381 NS NS ENSP00000275493.2:p.Thr909Ser ENST00000275493.6:c.2726C>G 7:g.55198741C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-32-2632-01 2120352 1994588 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 133204881 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 329 NS NS 80 ENSP00000415559.1:p.Leu62Arg ENST00000455089.5:c.185T>G 7:g.55142382T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982788 982788 898507 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-14-1827-01 2178235 2046533 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99295901 COSM7467664 133256828 c.368C>T p.S123F Substitution - Missense 38 7:55143432-55143432 + - PATHOGENIC .82087 Confirmed somatic variant 329 NS NS 51 ENSP00000415559.1:p.Ser123Phe ENST00000455089.5:c.368C>T 7:g.55143432C>T EGFR ENST00000275493.6 3633 3236 2876600 2876600 2731115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 99392475 c.2390G>C p.C797S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 42 ENSP00000275493.2:p.Cys797Ser ENST00000275493.6:c.2390G>C 7:g.55181399G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-VQ-A8P5-01 2339762 2204745 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51780766 COSM219795 133202085 c.2456C>T p.A819V Substitution - Missense 38 7:55191840-55191840 + - PATHOGENIC .93098 Confirmed somatic variant 541 NS primary 67 ENSP00000415559.1:p.Ala819Val ENST00000455089.5:c.2456C>T 7:g.55191840C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876603 2876603 2731118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 circulating tumour NS 60 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PM02T 2653317 2513444 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 26647728 NS primary 75.8 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CTS149 2393053 2255884 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 66 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471533 1471533 1395272 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982882 982882 898601 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1458693 1458693 1382668 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20473935 surgery fresh/frozen NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1471543 1471543 1395282 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 21067269 surgery - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1790520 1790520 1693499 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 16152581 fixed - NOS NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0010131-T01-IM5 2725939 2584760 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 P-0002523-T01-IM3 2718789 2577610 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 CT241 2393070 2255901 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 55 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2152770 2152770 2021780 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 86770 1520642 1443017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20668451 NS primary ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920019 920019 837098 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 68 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 920025 920025 837104 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 52 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 2876044 2876044 2730559 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 99373206 c.2573T>G p.L858R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 52 ENSP00000275493.2:p.Leu858Arg ENST00000275493.6:c.2573T>G 7:g.55191822T>G EGFR ENST00000275493.6 3633 3236 Case6 1943622 1830532 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 23563269 NS NS 75 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR ENST00000275493.6 3633 3236 2876600 2876600 2731115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 99373218 c.2369C>T p.T790M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 42 ENSP00000275493.2:p.Thr790Met ENST00000275493.6:c.2369C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 BK0004 2237563 2105067 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51826868 COSM4185521 133246869 c.2505G>T p.W835C Substitution - Missense 38 7:55192780-55192780 + - PATHOGENIC .96888 Confirmed somatic variant 24504440 surgery - NOS NS ENSP00000415559.1:p.Trp835Cys ENST00000455089.5:c.2505G>T 7:g.55192780G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0001826-T01-IM3 2718069 2576890 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1486987 1486987 1410605 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51777202 COSM20896 133246500 c.2365G>A p.V789M Substitution - Missense 38 7:55191749-55191749 + - PATHOGENIC .98912 Confirmed somatic variant 16567021 surgery-fixed primary 58 ENSP00000415559.1:p.Val789Met ENST00000455089.5:c.2365G>A 7:g.55191749G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1486993 1486993 1410611 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51789362 COSM13184 133232364 c.2101G>A p.E701K Substitution - Missense 38 7:55174773-55174773 + - PATHOGENIC .99624 Confirmed somatic variant 16567021 surgery-fixed primary 44 ENSP00000415559.1:p.Glu701Lys ENST00000455089.5:c.2101G>A 7:g.55174773G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-AA-A00N-01 1651102 1565889 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51852585 COSM274945 133215546 c.791G>A p.R264Q Substitution - Missense 38 7:55155866-55155866 + - PATHOGENIC .98601 Confirmed somatic variant 22810696 376 NS NS 75 ENSP00000415559.1:p.Arg264Gln ENST00000455089.5:c.791G>A 7:g.55155866G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1131222 1131222 1044000 upper_aerodigestive_tract pharynx oropharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51770694 COSM20891 133218993 c.2251G>A p.G751S Substitution - Missense het 38 7:55181395-55181395 + - PATHOGENIC .98244 Confirmed somatic variant 18528899 fresh/frozen - NOS NS 53 ENSP00000415559.1:p.Gly751Ser ENST00000455089.5:c.2251G>A 7:g.55181395G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1713253 1713253 1620987 peritoneum NS NS NS mesothelioma epithelial NS NS n COSV51793933 COSM250050 133268287 c.2435G>A p.G812E Substitution - Missense het 38 7:55191819-55191819 + - PATHOGENIC .98882 Confirmed somatic variant 22412050 surgery-fixed NS 41 ENSP00000415559.1:p.Gly812Glu ENST00000455089.5:c.2435G>A 7:g.55191819G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T660 2296260 2161863 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51781835 COSM174732 133207258 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 25344691 NS NS 66.58 ENSP00000415559.1:p.Glu114Lys ENST00000455089.5:c.340G>A 7:g.55143404G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0011503-T01-IM5 2727075 2585896 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 133220832 c.1658G>C p.G553A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly553Ala ENST00000455089.5:c.1658G>C 7:g.55165350G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CHC892T 2340454 2205437 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51854735 COSM4794914 133240335 c.3007G>A p.A1003T Substitution - Missense 38 7:55201762-55201762 + - NEUTRAL .20234 Confirmed somatic variant 381 NS primary 72 ENSP00000415559.1:p.Ala1003Thr ENST00000455089.5:c.3007G>A 7:g.55201762G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003068-T01-IM5 2719577 2578398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51843270 COSM6926023 133227874 c.953C>A p.T318N Substitution - Missense het 38 7:55156614-55156614 + - PATHOGENIC .99429 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Thr318Asn ENST00000455089.5:c.953C>A 7:g.55156614C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005464-T01-IM5 2721855 2580676 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211131 1211131 1122999 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen metastasis 45 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876057 2876057 2730572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 56 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876603 2876603 2731118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766493 COSM6493937 133216269 c.2254T>A p.C752S Substitution - Missense 38 7:55181398-55181398 + Yes PATHOGENIC .95568 Confirmed somatic variant 29506987 circulating tumour NS 60 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2254T>A 7:g.55181398T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1043243 1043243 959584 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51779524 COSM18425 133207486 c.2021G>A p.G674D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Confirmed somatic variant 17142003 surgery fresh/frozen primary ENSP00000415559.1:p.Gly674Asp ENST00000455089.5:c.2021G>A 7:g.55174015G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-KT-A7W1-01 2262770 2129754 central_nervous_system brain NS NS glioma NS NS NS y COSV51779524 COSM18425 133207486 c.2021G>A p.G674D Substitution - Missense 38 7:55174015-55174015 + - PATHOGENIC .97987 Confirmed somatic variant 545 NS primary 45 ENSP00000415559.1:p.Gly674Asp ENST00000455089.5:c.2021G>A 7:g.55174015G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1468097 1468097 1391943 peritoneum NS NS NS mesothelioma NS NS NS n COSV51801471 COSM53105 133208181 c.2357G>A p.R786H Substitution - Missense het 38 7:55191741-55191741 + - PATHOGENIC .96289 Confirmed somatic variant 20942962 surgery-fixed NS ENSP00000415559.1:p.Arg786His ENST00000455089.5:c.2357G>A 7:g.55191741G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1206737 1206737 1118615 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 19088172 surgery-fixed primary ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000583-T01-IM3 2715566 2574387 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0009535-T01-IM5 2725452 2584273 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense het 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982778 982778 898497 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51798694 COSM18419 133277561 c.2065G>A p.E689K Substitution - Missense 38 7:55174737-55174737 + - PATHOGENIC .99879 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Glu689Lys ENST00000455089.5:c.2065G>A 7:g.55174737G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD42095c 2894834 2749322 skin extremity NS NS malignant_melanoma in_situ_melanotic_neoplasm NS NS y COSV51767260 COSM12988 133202301 c.1990G>A p.E664K Substitution - Missense 38 7:55173984-55173984 + - PATHOGENIC .98158 Confirmed somatic variant 33024263 surgery-fixed metastasis 56 ENSP00000415559.1:p.Glu664Lys ENST00000455089.5:c.1990G>A 7:g.55173984G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000681-T02-IM5 2719371 2578192 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769339 COSM6239 133203054 c.2021G>C p.G674A Substitution - Missense het 38 7:55174015-55174015 + - PATHOGENIC .98253 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Gly674Ala ENST00000455089.5:c.2021G>C 7:g.55174015G>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000583-T01-IM3 2715566 2574387 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 GB052T 2634017 2494413 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 133202931 c.529C>T p.R177C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 672 NS primary ENSP00000415559.1:p.Arg177Cys ENST00000455089.5:c.529C>T 7:g.55152581C>T AWAT2 ENST00000276101.7 1002 23251 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105866772 COSM10012828 99677454 c.328G>T p.G110W Substitution - Missense 38 23:70043622-70043622 - - PATHOGENIC .96135 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000421172.1:p.Gly110Trp ENST00000276101.7:c.328G>T X:g.70043622C>A CYBB ENST00000378588.4 1713 2578 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV66084815 COSM385219 113848809 c.218G>A p.R73Q Substitution - Missense 38 23:37783566-37783566 + - PATHOGENIC .93478 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000367851.4:p.Arg73Gln ENST00000378588.4:c.218G>A X:g.37783566G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005435-T01-IM5 2721825 2580646 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 982778 982778 898497 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 16533793 surgery fresh/frozen primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1040346 1040346 956923 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_II NS NS n COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010131-T01-IM5 2725939 2584760 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0002523-T01-IM3 2718789 2577610 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 28481359 fixed - NOS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920025 920025 837104 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 52 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876044 2876044 2730559 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 29506987 NS primary 52 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 920019 920019 837098 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense het 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 15623594 surgery fresh/frozen NS 68 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 CT241 2393070 2255901 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 25189529 surgery fresh/frozen NS 55 ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2152770 2152770 2021780 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 24788590 surgery-fixed NS ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 86770 1520642 1443017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765161 COSM6224 133202008 c.2438T>G p.L813R Substitution - Missense 38 7:55191822-55191822 + - PATHOGENIC .98142 Confirmed somatic variant 20668451 NS primary ENSP00000415559.1:p.Leu813Arg ENST00000455089.5:c.2438T>G 7:g.55191822T>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T116 2658237 2518396 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51773524 COSM1090858 133204241 c.418T>G p.L140V Substitution - Missense 38 7:55143482-55143482 + - NEUTRAL .25717 Confirmed somatic variant 27149842 NS NS 52.58 ENSP00000415559.1:p.Leu140Val ENST00000455089.5:c.418T>G 7:g.55143482T>G HTR3E ENST00000440596.2 1449 24005 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105899663 COSM10012911 130050719 c.586C>A p.P196T Substitution - Missense 38 3:184104905-184104905 + - PATHOGENIC .98714 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000406050.2:p.Pro196Thr ENST00000440596.2:c.586C>A 3:g.184104905C>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 86770 1520642 1443017 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51850613 COSM94183 133264145 c.2135A>T p.K712M Substitution - Missense 38 7:55174807-55174807 + - PATHOGENIC .99468 Confirmed somatic variant 20668451 NS primary ENSP00000415559.1:p.Lys712Met ENST00000455089.5:c.2135A>T 7:g.55174807A>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0000686-T01-IM3 2715784 2574605 skin NS NS NS malignant_melanoma NS NS NS n COSV51781503 COSM5608352 133226045 c.1774C>T p.P592S Substitution - Missense het 38 7:55171203-55171203 + - NEUTRAL .1586 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000415559.1:p.Pro592Ser ENST00000455089.5:c.1774C>T 7:g.55171203C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 RK308_C01 2194686 2062964 liver NS NS NS carcinoma NS NS NS y COSV51780206 COSM12373 133208468 c.2024C>T p.S675F Substitution - Missense 38 7:55174018-55174018 + - PATHOGENIC .9768 Confirmed somatic variant 322 NS NS ENSP00000415559.1:p.Ser675Phe ENST00000455089.5:c.2024C>T 7:g.55174018C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876603 2876603 2731118 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 60 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876048 2876048 2730563 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 29506987 NS recurrent 44 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211143 1211143 1123011 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen recurrent 50 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1211144 1211144 1123012 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + Yes PATHOGENIC .94063 Confirmed somatic variant 19381876 surgery fresh/frozen metastasis 70 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876626 2876626 2731141 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 69 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0010053-T01-IM5 2725865 2584686 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766344 COSM6213 133204235 c.2447T>A p.L816Q Substitution - Missense het 38 7:55191831-55191831 + - PATHOGENIC .9807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Leu816Gln ENST00000455089.5:c.2447T>A 7:g.55191831T>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876600 2876600 2731115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51766509 COSM5945664 133219858 c.2255G>C p.C752S Substitution - Missense 38 7:55181399-55181399 + Yes PATHOGENIC .98511 Confirmed somatic variant 29506987 circulating tumour NS 42 ENSP00000415559.1:p.Cys752Ser ENST00000455089.5:c.2255G>C 7:g.55181399G>C GOLGA6L10_ENST00000621197 ENST00000621197.4 1320 37228 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV73782728 COSM190514 168659808 c.451G>C p.E151Q Substitution - Missense 38 15:82345409-82345409 - - NEUTRAL .02811 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000484254.2:p.Glu151Gln ENST00000621197.4:c.451G>C 15:g.82345409C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-4W-AA9T-01 2339571 2204554 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 133205872 c.731C>T p.A244V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS primary 54 ENSP00000415559.1:p.Ala244Val ENST00000455089.5:c.731C>T 7:g.55154129C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0005943-T01-IM5 2722326 2581147 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51829196 COSM6947106 133217667 c.3068G>A p.R1023Q Substitution - Missense het 38 7:55202557-55202557 + - PATHOGENIC .97786 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000415559.1:p.Arg1023Gln ENST00000455089.5:c.3068G>A 7:g.55202557G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0012194-T01-IM5 2727317 2586138 skin NS NS NS malignant_melanoma NS NS NS n COSV51860991 COSM6983544 133211689 c.97_98delinsAA p.G33N Substitution - Missense het 38 7:55142294-55142295 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Gly33Asn ENST00000455089.5:c.97_98delinsAA 7:g.55142294_55142295delinsAA EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-06-0878-01 1337866 1248251 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 133202242 c.730G>A p.A244T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 74 ENSP00000415559.1:p.Ala244Thr ENST00000455089.5:c.730G>A 7:g.55154128G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 TCGA-A8-A094-01 1779383 1683382 breast NS NS NS carcinoma NS NS NS y COSV51768800 COSM6499385 133225194 c.709G>A p.E237K Substitution - Missense 38 7:55154107-55154107 + - PATHOGENIC .81806 Confirmed somatic variant 414 fresh/frozen - NOS primary 75 ENSP00000415559.1:p.Glu237Lys ENST00000455089.5:c.709G>A 7:g.55154107G>A EGFR_ENST00000455089 ENST00000455089.5 3276 3236 1486996 1486996 1410614 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51811013 COSM85960 133278918 c.2126A>G p.K709R Substitution - Missense 38 7:55174798-55174798 + - PATHOGENIC .9918 Confirmed somatic variant 16567021 surgery-fixed primary 68 ENSP00000415559.1:p.Lys709Arg ENST00000455089.5:c.2126A>G 7:g.55174798A>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 P-0003170-T01-IM5 2719663 2578484 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51841905 COSM6926730 133205629 c.796T>C p.C266R Substitution - Missense het 38 7:55155871-55155871 + - PATHOGENIC .98694 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000415559.1:p.Cys266Arg ENST00000455089.5:c.796T>C 7:g.55155871T>C EGFR_ENST00000455089 ENST00000455089.5 3276 3236 PD5757a 1465371 1389218 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51785945 COSM4384127 133256560 c.2591C>G p.T864S Substitution - Missense 38 7:55198741-55198741 + - PATHOGENIC .992 Confirmed somatic variant 24030381 NS NS ENSP00000415559.1:p.Thr864Ser ENST00000455089.5:c.2591C>G 7:g.55198741C>G EGFR_ENST00000455089 ENST00000455089.5 3276 3236 T116 2658237 2518396 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51787894 COSM6652229 133239417 c.84G>T p.K28N Substitution - Missense 38 7:55019361-55019361 + - NEUTRAL .32765 Confirmed somatic variant 27149842 NS NS 52.58 ENSP00000415559.1:p.Lys28Asn ENST00000455089.5:c.84G>T 7:g.55019361G>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876600 2876600 2731115 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 29506987 circulating tumour NS 42 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 Case6 1943622 1830532 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS y COSV51765492 COSM6240 133202022 c.2234C>T p.T745M Substitution - Missense 38 7:55181378-55181378 + - PATHOGENIC .94063 Confirmed somatic variant 23563269 NS NS 75 ENSP00000415559.1:p.Thr745Met ENST00000455089.5:c.2234C>T 7:g.55181378C>T EGFR_ENST00000455089 ENST00000455089.5 3276 3236 2876649 2876649 2731164 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV105111022 COSM9869939 133281505 c.2140A>C p.I714L Substitution - Missense 38 7:55174812-55174812 + - PATHOGENIC .99492 Confirmed somatic variant 29506987 circulating tumour NS 48 ENSP00000415559.1:p.Ile714Leu ENST00000455089.5:c.2140A>C 7:g.55174812A>C PAPOLB ENST00000404991.1 1914 15970 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105935627 COSM10012876 120188645 c.1384C>A p.Q462K Substitution - Missense 38 7:4860427-4860427 - - PATHOGENIC .97734 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000384700.2:p.Gln462Lys ENST00000404991.1:c.1384C>A 7:g.4860427G>T LEPR ENST00000349533.10 3498 6554 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV62747065 COSM4009479 107563881 c.2959G>A p.A987T Substitution - Missense 38 1:65636476-65636476 + - PATHOGENIC .98134 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000330393.6:p.Ala987Thr ENST00000349533.10:c.2959G>A 1:g.65636476G>A PTPDC1 ENST00000620992.4 2427 30184 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105860297 COSM10012886 168270404 c.560C>T p.P187L Substitution - Missense 38 9:94088207-94088207 + - PATHOGENIC .9798 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000477817.1:p.Pro187Leu ENST00000620992.4:c.560C>T 9:g.94088207C>T MTSS1L ENST00000338779.10 2244 25094 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105912132 COSM10012770 103656653 c.956G>A p.R319H Substitution - Missense 38 16:70674403-70674403 - - PATHOGENIC .95665 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000341171.6:p.Arg319His ENST00000338779.10:c.956G>A 16:g.70674403C>T ZNF334_ENST00000457685 ENST00000457685.6 1929 15806 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV61619438 COSM1027463 131493036 c.1799G>A p.R600H Substitution - Missense 38 20:46501426-46501426 - - NEUTRAL .00039 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000402582.1:p.Arg600His ENST00000457685.6:c.1799G>A 20:g.46501426C>T C2CD2_ENST00000329623 ENST00000329623.11 1626 1266 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105882773 COSM10012964 102351434 c.848G>T p.S283I Substitution - Missense 38 21:41906997-41906997 - - PATHOGENIC .80898 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000329302.7:p.Ser283Ile ENST00000329623.11:c.848G>T 21:g.41906997C>A FAT2 ENST00000261800.5 13050 3596 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV55823153 COSM3975338 99581860 c.4025C>T p.P1342L Substitution - Missense 38 5:151553308-151553308 - - PATHOGENIC .96003 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000261800.5:p.Pro1342Leu ENST00000261800.5:c.4025C>T 5:g.151553308G>A MVB12B ENST00000361171.7 960 23368 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV100752907 COSM8124387 110243386 c.865G>A p.E289K Substitution - Missense 38 9:126484024-126484024 + - PATHOGENIC .99662 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000354772.3:p.Glu289Lys ENST00000361171.7:c.865G>A 9:g.126484024G>A CSMD3_ENST00000455883 ENST00000455883.2 10617 19291 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105904311 COSM10012881 131745855 c.7553C>A p.A2518E Substitution - Missense 38 8:112310998-112310998 - - PATHOGENIC .97269 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000412263.2:p.Ala2518Glu ENST00000455883.2:c.7553C>A 8:g.112310998G>T TTN_ENST00000360870 ENST00000360870.9 16815 12403 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105912072 COSM10012820 109555652 c.9543A>T p.K3181N Substitution - Missense 38 2:178766541-178766541 - - PATHOGENIC .90433 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000354117.4:p.Lys3181Asn ENST00000360870.9:c.9543A>T 2:g.178766541T>A TTN_ENST00000360870 ENST00000360870.9 16815 12403 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV59957361 COSM130006 109573088 c.184C>T p.R62C Substitution - Missense 38 2:178802249-178802249 - - PATHOGENIC .99021 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000354117.4:p.Arg62Cys ENST00000360870.9:c.184C>T 2:g.178802249G>A VPS13B_ENST00000357162 ENST00000357162.6 11994 2183 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105910679 COSM10012777 110653354 c.2747C>T p.P916L Substitution - Missense 38 8:99275177-99275177 + - PATHOGENIC .97749 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000349685.2:p.Pro916Leu ENST00000357162.6:c.2747C>T 8:g.99275177C>T SEZ6_ENST00000442608 ENST00000442608.7 2943 15955 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105887926 COSM10012920 129666853 c.1904T>C p.I635T Substitution - Missense 38 17:28959340-28959340 - - PATHOGENIC .9935 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000403784.3:p.Ile635Thr ENST00000442608.7:c.1904T>C 17:g.28959340A>G CSMD3_ENST00000455883 ENST00000455883.2 10617 19291 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105903899 COSM10012835 131678871 c.8433T>A p.N2811K Substitution - Missense 38 8:112291544-112291544 - - PATHOGENIC .90952 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000412263.2:p.Asn2811Lys ENST00000455883.2:c.8433T>A 8:g.112291544A>T CLCNKA_ENST00000439316 ENST00000439316.6 1935 2026 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV58890629 COSM1737785 127517681 c.1600A>G p.T534A Substitution - Missense 38 1:16031816-16031816 + - NEUTRAL .00395 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000414445.2:p.Thr534Ala ENST00000439316.6:c.1600A>G 1:g.16031816A>G SLC4A4_ENST00000264485 ENST00000264485.10 3240 11030 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV52623703 COSM420534 100044813 c.2308G>A p.V770I Substitution - Missense 38 4:71534254-71534254 + - PATHOGENIC .91286 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000264485.5:p.Val770Ile ENST00000264485.10:c.2308G>A 4:g.71534254G>A HBZ ENST00000252951.2 429 4835 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV53316519 COSM3370345 97365396 c.23G>A p.R8K Substitution - Missense 38 16:152932-152932 + - NEUTRAL .35831 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000252951.2:p.Arg8Lys ENST00000252951.2:c.23G>A 16:g.152932G>A FBXL7 ENST00000504595.1 1476 13604 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV61649228 COSM5743062 144004340 c.1136G>A p.R379H Substitution - Missense 38 5:15936846-15936846 + - PATHOGENIC .98974 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000423630.1:p.Arg379His ENST00000504595.1:c.1136G>A 5:g.15936846G>A HNRNPM_ENST00000620401 ENST00000620401.4 2193 5046 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105881442 COSM10012792 169140742 c.548T>A p.I183N Substitution - Missense 38 19:8465433-8465433 + - PATHOGENIC .96736 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000483715.1:p.Ile183Asn ENST00000620401.4:c.548T>A 19:g.8465433T>A MTCL1 ENST00000359865.7 4761 29121 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV60406354 COSM5665008 110994668 c.1081G>A p.A361T Substitution - Missense 38 18:8784193-8784193 + - PATHOGENIC .91329 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000352927.3:p.Ala361Thr ENST00000359865.7:c.1081G>A 18:g.8784193G>A C1RL ENST00000266542.8 1464 21265 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV56923985 COSM2101631 98555676 c.406C>T p.R136W Substitution - Missense 38 12:7101982-7101982 - - NEUTRAL .10223 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000266542.4:p.Arg136Trp ENST00000266542.8:c.406C>T 12:g.7101982G>A ABCC8_ENST00000389817 ENST00000389817.7 4746 59 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105879570 COSM10012873 117319632 c.2057T>C p.F686S Substitution - Missense 38 11:17427926-17427926 - - PATHOGENIC .98111 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000374467.3:p.Phe686Ser ENST00000389817.7:c.2057T>C 11:g.17427926A>G KIFC3_ENST00000421376 ENST00000421376.6 2064 6326 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65551650 COSM971903 123042514 c.277C>T p.R93W Substitution - Missense 38 16:57771269-57771269 - - PATHOGENIC .87712 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000396399.2:p.Arg93Trp ENST00000421376.6:c.277C>T 16:g.57771269G>A DTX1 ENST00000257600.3 1863 3060 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57497378 COSM4038928 100643108 c.122C>T p.T41M Substitution - Missense 38 12:113058314-113058314 + - PATHOGENIC .87259 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000257600.3:p.Thr41Met ENST00000257600.3:c.122C>T 12:g.113058314C>T OR10K1 ENST00000641432.1 942 14693 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV56872727 COSM5698964 173635889 c.346G>T p.A116S Substitution - Missense 38 1:158465907-158465907 + - .50134 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000493023.1:p.Ala116Ser ENST00000641432.1:c.346G>T 1:g.158465907G>T SYNE1_ENST00000341594 ENST00000341594.9 25179 17089 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV55014875 COSM7191704 102939407 c.16943G>A p.R5648Q Substitution - Missense 38 6:152284027-152284027 - - PATHOGENIC .98502 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000341887.6:p.Arg5648Gln ENST00000341594.9:c.16943G>A 6:g.152284027C>T WSCD1_ENST00000539421 ENST00000539421.1 1728 29060 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV58497674 COSM4749261 154790825 c.695G>A p.R232H Substitution - Missense 38 17:6090473-6090473 + - PATHOGENIC .71202 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000446032.1:p.Arg232His ENST00000539421.1:c.695G>A 17:g.6090473G>A DCAF4_ENST00000394234 ENST00000394234.6 1188 20229 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105912372 COSM10012834 116974284 c.20G>A p.R7Q Substitution - Missense 38 14:72940346-72940346 + - NEUTRAL .14934 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000377781.2:p.Arg7Gln ENST00000394234.6:c.20G>A 14:g.72940346G>A BRAF ENST00000646891.1 2301 1097 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV56056643 COSM476 176613177 c.1799T>A p.V600E Substitution - Missense 38 7:140753336-140753336 - - PATHOGENIC .98542 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000493543.1:p.Val600Glu ENST00000646891.1:c.1799T>A 7:g.140753336A>T BRSK1_ENST00000585418 ENST00000585418.1 1032 18994 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105897071 COSM10012785 163207457 c.436T>A p.F146I Substitution - Missense 38 19:55289598-55289598 + - PATHOGENIC .95752 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000467357.1:p.Phe146Ile ENST00000585418.1:c.436T>A 19:g.55289598T>A F7_ENST00000346342 ENST00000346342.7 1335 3544 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105916177 COSM10012857 106726439 c.757G>A p.E253K Substitution - Missense 38 13:113118430-113118430 + - NEUTRAL .06932 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000329546.3:p.Glu253Lys ENST00000346342.7:c.757G>A 13:g.113118430G>A MAF_ENST00000569649 ENST00000569649.1 1152 6776 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105884268 COSM10012914 159886057 c.1008G>T p.R336S Substitution - Missense 38 16:79598895-79598895 - - PATHOGENIC .96375 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000455097.1:p.Arg336Ser ENST00000569649.1:c.1008G>T 16:g.79598895C>A ZFYVE9_ENST00000371591 ENST00000371591.1 4278 6775 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV55095322 COSM910631 112478064 c.3397C>T p.R1133W Substitution - Missense 38 1:52303884-52303884 + - PATHOGENIC .76999 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000360647.1:p.Arg1133Trp ENST00000371591.1:c.3397C>T 1:g.52303884C>T BRAF_ENST00000496384 ENST00000496384.7 2304 1097 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV56056643 COSM476 141133440 c.1799T>A p.V600E Substitution - Missense 38 7:140753336-140753336 - - PATHOGENIC .98542 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000419060.2:p.Val600Glu ENST00000496384.7:c.1799T>A 7:g.140753336A>T MYH6_ENST00000356287 ENST00000356287.3 5820 7576 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105908359 COSM10012806 108089058 c.3346C>T p.R1116C Substitution - Missense 38 14:23390443-23390443 - - PATHOGENIC .98819 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000348634.3:p.Arg1116Cys ENST00000356287.3:c.3346C>T 14:g.23390443G>A NEK8 ENST00000268766.10 2079 13387 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105868369 COSM10012937 99825666 c.1055G>A p.R352H Substitution - Missense 38 17:28737984-28737984 + - PATHOGENIC .98827 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000268766.6:p.Arg352His ENST00000268766.10:c.1055G>A 17:g.28737984G>A SMOX_ENST00000379460 ENST00000379460.6 1668 15862 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105846220 COSM10009557 116683935 c.841C>T p.R281W Substitution - Missense 38 20:4182320-4182320 + - .51649 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000368773.2:p.Arg281Trp ENST00000379460.6:c.841C>T 20:g.4182320C>T FCGR3A ENST00000638849.1 873 3619 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV63460316 COSM4224348 171974171 c.362G>T p.G121V Substitution - Missense 38 1:161548486-161548486 - - .64272 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000491631.1:p.Gly121Val ENST00000638849.1:c.362G>T 1:g.161548486C>A NOC4L ENST00000330579.5 1551 28461 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105888340 COSM10012922 103066386 c.817C>A p.L273M Substitution - Missense 38 12:132148811-132148811 + - PATHOGENIC .94664 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000328854.1:p.Leu273Met ENST00000330579.5:c.817C>A 12:g.132148811C>A P2RX3_ENST00000616487 ENST00000616487.4 1191 8534 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105840384 COSM10012941 170124733 c.998T>A p.V333E Substitution - Missense 38 11:57368436-57368436 + - PATHOGENIC .96172 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000484614.1:p.Val333Glu ENST00000616487.4:c.998T>A 11:g.57368436T>A NBPF3_ENST00000454000 ENST00000454000.6 1692 25076 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV59056369 COSM4166741 131172344 c.1061T>G p.F354C Substitution - Missense 38 1:21480113-21480113 + - NEUTRAL .00026 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000415711.2:p.Phe354Cys ENST00000454000.6:c.1061T>G 1:g.21480113T>G ZNF845 ENST00000458035.2 2913 25112 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV72003978 COSM369429 132280239 c.2774G>A p.R925H Substitution - Missense 38 19:53353449-53353449 + - NEUTRAL .01601 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000388311.1:p.Arg925His ENST00000458035.2:c.2774G>A 19:g.53353449G>A ADGRG3 ENST00000333493.8 1650 13728 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV59652971 COSM5612679 106051517 c.791C>T p.T264M Substitution - Missense 38 16:57680527-57680527 + - NEUTRAL .48847 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000332900.4:p.Thr264Met ENST00000333493.8:c.791C>T 16:g.57680527C>T ARSG ENST00000448504.6 1578 24102 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV71593687 COSM193997 131999073 c.391G>A p.V131I Substitution - Missense 38 17:68343776-68343776 + - NEUTRAL .09327 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000407193.2:p.Val131Ile ENST00000448504.6:c.391G>A 17:g.68343776G>A SMOX_ENST00000339123 ENST00000339123.10 1509 15862 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105846220 COSM10009557 104163957 c.841C>T p.R281W Substitution - Missense 38 20:4182320-4182320 + - .51649 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000344595.6:p.Arg281Trp ENST00000339123.10:c.841C>T 20:g.4182320C>T ADAMTS16_ENST00000511368 ENST00000511368.5 1713 17108 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV99942982 COSM8518954 144240426 c.253C>T p.R85W Substitution - Missense 38 5:5146207-5146207 + - NEUTRAL .42675 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000421631.1:p.Arg85Trp ENST00000511368.5:c.253C>T 5:g.5146207C>T TTN ENST00000589042.5 107976 12403 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105912072 COSM10012820 163017175 c.9543A>T p.K3181N Substitution - Missense 38 2:178766541-178766541 - - PATHOGENIC .90433 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000467141.1:p.Lys3181Asn ENST00000589042.5:c.9543A>T 2:g.178766541T>A TUBA3E ENST00000312988.8 1353 20765 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV56060251 COSM6438792 105985319 c.640C>T p.R214W Substitution - Missense 38 2:130194202-130194202 - - PATHOGENIC .74772 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000318197.7:p.Arg214Trp ENST00000312988.8:c.640C>T 2:g.130194202G>A L3MBTL1_ENST00000373134 ENST00000373134.5 2232 15905 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105927443 COSM10012772 113401014 c.1382G>A p.R461K Substitution - Missense 38 20:43534336-43534336 + - PATHOGENIC .99127 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000362226.1:p.Arg461Lys ENST00000373134.5:c.1382G>A 20:g.43534336G>A TTN ENST00000589042.5 107976 12403 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV59957361 COSM130006 163094749 c.184C>T p.R62C Substitution - Missense 38 2:178802249-178802249 - - PATHOGENIC .99021 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000467141.1:p.Arg62Cys ENST00000589042.5:c.184C>T 2:g.178802249G>A SPTA1_ENST00000368147 ENST00000368147.8 7260 11272 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV63523825 COSM4975995 110338194 c.7202G>A p.R2401Q Substitution - Missense 38 1:158611322-158611322 - - NEUTRAL .29923 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000357129.4:p.Arg2401Gln ENST00000368147.8:c.7202G>A 1:g.158611322C>T GREB1_ENST00000396123 ENST00000396123.2 2844 24885 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV52193807 COSM5010782 120205525 c.2737C>T p.R913C Substitution - Missense 38 2:11640347-11640347 + - PATHOGENIC .81416 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000379429.1:p.Arg913Cys ENST00000396123.2:c.2737C>T 2:g.11640347C>T PLCL2 ENST00000615277.4 3384 9064 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105936602 COSM10012889 166593141 c.2174G>T p.G725V Substitution - Missense 38 3:17011520-17011520 + - PATHOGENIC .9886 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000478458.1:p.Gly725Val ENST00000615277.4:c.2174G>T 3:g.17011520G>T CHD9_ENST00000566029 ENST00000566029.5 8646 25701 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105871502 COSM10012854 158958354 c.7071A>C p.E2357D Substitution - Missense 38 16:53308751-53308751 + - PATHOGENIC .86656 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000457466.1:p.Glu2357Asp ENST00000566029.5:c.7071A>C 16:g.53308751A>C CHD9_ENST00000398510 ENST00000398510.7 8694 25701 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105871502 COSM10012854 118215615 c.7119A>C p.E2373D Substitution - Missense 38 16:53308751-53308751 + - PATHOGENIC .86656 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000381522.3:p.Glu2373Asp ENST00000398510.7:c.7119A>C 16:g.53308751A>C LRP2 ENST00000263816.7 13968 6694 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV55556222 COSM1009183 98342208 c.11177G>A p.R3726H Substitution - Missense 38 2:169172101-169172101 - - PATHOGENIC .98932 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000263816.3:p.Arg3726His ENST00000263816.7:c.11177G>A 2:g.169172101C>T FCGR3A_ENST00000367969 ENST00000367969.8 1080 3619 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV63460316 COSM4224348 109800411 c.569G>T p.G190V Substitution - Missense 38 1:161548486-161548486 - - .64272 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000356946.4:p.Gly190Val ENST00000367969.8:c.569G>T 1:g.161548486C>A OR7C1_ENST00000641666 ENST00000641666.1 963 8373 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV50183885 COSM1390989 174710300 c.364C>T p.R122C Substitution - Missense 38 19:14799773-14799773 - - .5891 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000493429.1:p.Arg122Cys ENST00000641666.1:c.364C>T 19:g.14799773G>A DSEL ENST00000310045.7 3669 18144 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105901923 COSM10012850 102979026 c.2199C>A p.N733K Substitution - Missense 38 18:67512440-67512440 - - PATHOGENIC .93247 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000310565.7:p.Asn733Lys ENST00000310045.7:c.2199C>A 18:g.67512440G>T ADGRG3_ENST00000450388 ENST00000450388.7 1290 13728 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV59652971 COSM5612679 131388763 c.431C>T p.T144M Substitution - Missense 38 16:57680527-57680527 + - NEUTRAL .48847 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000404803.3:p.Thr144Met ENST00000450388.7:c.431C>T 16:g.57680527C>T FRY_ENST00000645780 ENST00000645780.1 8892 20367 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105932591 COSM10012802 175257626 c.1819G>A p.D607N Substitution - Missense 38 13:32171088-32171088 + - PATHOGENIC .96279 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000494080.1:p.Asp607Asn ENST00000645780.1:c.1819G>A 13:g.32171088G>A CHD9_ENST00000615216 ENST00000615216.4 2892 25701 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105871502 COSM10012854 166526023 c.1317A>C p.E439D Substitution - Missense 38 16:53308751-53308751 + - PATHOGENIC .86656 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000478361.1:p.Glu439Asp ENST00000615216.4:c.1317A>C 16:g.53308751A>C ADAMTS16 ENST00000274181.7 3675 17108 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV99942982 COSM8518954 98648609 c.253C>T p.R85W Substitution - Missense 38 5:5146207-5146207 + - NEUTRAL .42675 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000274181.7:p.Arg85Trp ENST00000274181.7:c.253C>T 5:g.5146207C>T FAM78B ENST00000338353.3 786 13495 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57975578 COSM4798871 103003133 c.157G>A p.A53T Substitution - Missense 38 1:166166092-166166092 - - PATHOGENIC .96596 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000339681.3:p.Ala53Thr ENST00000338353.3:c.157G>A 1:g.166166092C>T ADAMTS16 ENST00000274181.7 3675 17108 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV56981665 COSM390241 98640350 c.2629G>A p.V877M Substitution - Missense 38 5:5242158-5242158 + - NEUTRAL .02345 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000274181.7:p.Val877Met ENST00000274181.7:c.2629G>A 5:g.5242158G>A PKNOX2 ENST00000298282.13 1419 16714 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105879781 COSM10012844 98982874 c.491C>A p.T164N Substitution - Missense 38 11:125397965-125397965 + - PATHOGENIC .99626 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000298282.8:p.Thr164Asn ENST00000298282.13:c.491C>A 11:g.125397965C>A KANK1 ENST00000619269.4 4059 19309 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105916423 COSM10012928 170449628 c.3077A>G p.D1026G Substitution - Missense 38 9:732449-732449 + - PATHOGENIC .96909 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000477725.1:p.Asp1026Gly ENST00000619269.4:c.3077A>G 9:g.732449A>G VPS13B ENST00000358544.6 12069 2183 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105910679 COSM10012777 110896122 c.2747C>T p.P916L Substitution - Missense 38 8:99275177-99275177 + - PATHOGENIC .97749 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000351346.2:p.Pro916Leu ENST00000358544.6:c.2747C>T 8:g.99275177C>T SLC13A2_ENST00000545060 ENST00000545060.2 1077 10917 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105903232 COSM10012975 157526528 c.309G>A p.M103I Substitution - Missense 38 17:28490773-28490773 + - PATHOGENIC .96983 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000441935.3:p.Met103Ile ENST00000545060.2:c.309G>A 17:g.28490773G>A ZNF334 ENST00000347606.8 2043 15806 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV61619438 COSM1027463 107792500 c.1913G>A p.R638H Substitution - Missense 38 20:46501426-46501426 - - NEUTRAL .00039 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000255129.5:p.Arg638His ENST00000347606.8:c.1913G>A 20:g.46501426C>T CEACAM20_ENST00000617951 ENST00000617951.1 1755 24879 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105885448 COSM10012840 170003733 c.211T>C p.S71P Substitution - Missense 38 19:44524247-44524247 - - NEUTRAL .07541 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000483639.1:p.Ser71Pro ENST00000617951.1:c.211T>C 19:g.44524247A>G EIF3M ENST00000531120.5 1125 24460 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV60073366 COSM109413 152675474 c.280C>T p.R94C Substitution - Missense 38 11:32588698-32588698 + - PATHOGENIC .9722 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000436049.1:p.Arg94Cys ENST00000531120.5:c.280C>T 11:g.32588698C>T TFAP2A_ENST00000379608 ENST00000379608.8 1296 11742 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105902772 COSM10012977 112907283 c.703C>A p.P235T Substitution - Missense 38 6:10404551-10404551 - - PATHOGENIC .96956 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000368928.3:p.Pro235Thr ENST00000379608.8:c.703C>A 6:g.10404551G>T FRY_ENST00000380250 ENST00000380250.7 9039 20367 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105932591 COSM10012802 115052835 c.1969G>A p.D657N Substitution - Missense 38 13:32171088-32171088 + - PATHOGENIC .96279 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000369600.4:p.Asp657Asn ENST00000380250.7:c.1969G>A 13:g.32171088G>A KANK1_ENST00000382303 ENST00000382303.5 4059 19309 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105916423 COSM10012928 116971818 c.3077A>G p.D1026G Substitution - Missense 38 9:732449-732449 + - PATHOGENIC .96909 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000371740.1:p.Asp1026Gly ENST00000382303.5:c.3077A>G 9:g.732449A>G VPS33B ENST00000333371.7 1854 12712 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV60980714 COSM5633052 105923630 c.662G>A p.R221Q Substitution - Missense 38 15:91006988-91006988 - - PATHOGENIC .91655 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000327650.3:p.Arg221Gln ENST00000333371.7:c.662G>A 15:g.91006988C>T DZANK1 ENST00000262547.9 2259 15858 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV52756978 COSM1024882 101325409 c.442C>T p.R148C Substitution - Missense 38 20:18453764-18453764 - - NEUTRAL .05574 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000262547.5:p.Arg148Cys ENST00000262547.9:c.442C>T 20:g.18453764G>A CHN1_ENST00000409597 ENST00000409597.5 828 1943 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105886981 COSM10012859 122609018 c.772C>T p.R258W Substitution - Missense 38 2:174800172-174800172 - - PATHOGENIC .98155 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000386469.1:p.Arg258Trp ENST00000409597.5:c.772C>T 2:g.174800172G>A NOX5 ENST00000388866.7 2298 14874 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105871370 COSM10012832 114360919 c.1187A>T p.E396V Substitution - Missense 38 15:69035935-69035935 + - PATHOGENIC .81287 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000373518.3:p.Glu396Val ENST00000388866.7:c.1187A>T 15:g.69035935A>T SCN2A_ENST00000375437 ENST00000375437.6 6018 10588 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105873046 COSM10012780 113038659 c.5288C>A p.S1763Y Substitution - Missense 38 2:165389094-165389094 + - PATHOGENIC .98186 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000364586.2:p.Ser1763Tyr ENST00000375437.6:c.5288C>A 2:g.165389094C>A SCN2A_ENST00000637266 ENST00000637266.2 6018 10588 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105873046 COSM10012780 172337413 c.5288C>A p.S1763Y Substitution - Missense 38 2:165389094-165389094 + - PATHOGENIC .98186 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000490866.1:p.Ser1763Tyr ENST00000637266.2:c.5288C>A 2:g.165389094C>A TBC1D8_ENST00000376840 ENST00000376840.8 3423 17791 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105928021 COSM10012949 112647070 c.2410C>G p.R804G Substitution - Missense 38 2:101027448-101027448 - - PATHOGENIC .88528 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000366036.4:p.Arg804Gly ENST00000376840.8:c.2410C>G 2:g.101027448G>C NOX5_ENST00000455873 ENST00000455873.7 2193 14874 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105871370 COSM10012832 131489206 c.1082A>T p.E361V Substitution - Missense 38 15:69035935-69035935 + - PATHOGENIC .81287 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000416828.3:p.Glu361Val ENST00000455873.7:c.1082A>T 15:g.69035935A>T SPEG ENST00000312358.11 9804 16901 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105889346 COSM10012960 105510383 c.9730G>A p.E3244K Substitution - Missense 38 2:219492712-219492712 + - PATHOGENIC .97968 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000311684.7:p.Glu3244Lys ENST00000312358.11:c.9730G>A 2:g.219492712G>A ZNF334_ENST00000615481 ENST00000615481.4 2040 15806 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV61619438 COSM1027463 167015711 c.1910G>A p.R637H Substitution - Missense 38 20:46501426-46501426 - - NEUTRAL .00039 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000484362.1:p.Arg637His ENST00000615481.4:c.1910G>A 20:g.46501426C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2862107 2862107 2717309 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV105111081 COSM9572577 174329968 c.835G>A p.G279S Substitution - Missense 38 7:55160293-55160293 + - NEUTRAL .00282 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000492462.1:p.Gly279Ser ENST00000638463.1:c.835G>A 7:g.55160293G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2840810 2840810 2696370 prostate NS NS NS carcinoma NS NS NS n COSV104577207 COSM9493802 174399882 c.68G>A p.S23N Substitution - Missense 38 7:55152603-55152603 + - PATHOGENIC .9474 Variant of unknown origin 31874108 surgery-fixed metastasis ENSP00000492462.1:p.Ser23Asn ENST00000638463.1:c.68G>A 7:g.55152603G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 5-GE067-T1 2869773 2724770 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51802062 COSM6008937 174330535 c.41C>T p.S14F Substitution - Missense 38 7:55152576-55152576 + - PATHOGENIC .98424 Variant of unknown origin 26950094 surgery - NOS NS ENSP00000492462.1:p.Ser14Phe ENST00000638463.1:c.41C>T 7:g.55152576C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1194724 1194724 1106619 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849762 COSM29340 174396654 c.200C>A p.T67N Substitution - Missense 38 7:55154081-55154081 + - PATHOGENIC .90357 Variant of unknown origin 19284481 surgery fresh/frozen primary ENSP00000492462.1:p.Thr67Asn ENST00000638463.1:c.200C>A 7:g.55154081C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0000030-T01-IM3 2714482 2573303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51789972 COSM6985979 174337926 c.285_288delinsACAC p.T96H Substitution - Missense het 38 7:55155843-55155846 + - Variant of unknown origin 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Thr96His ENST00000638463.1:c.285_288delinsACAC 7:g.55155843_55155846delinsACAC EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-24-1850-01 1731201 1637167 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51792742 COSM1330578 174394438 c.165G>T p.K55N Substitution - Missense het 38 7:55154046-55154046 + - PATHOGENIC .96256 Variant of unknown origin 331 NS primary 72 ENSP00000492462.1:p.Lys55Asn ENST00000638463.1:c.165G>T 7:g.55154046G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 UCHRP3 2682242 2541515 large_intestine NS NS NS other ulcerative_colitis dysplasia NS n COSV51844380 COSM6854567 174342214 c.238A>G p.S80G Substitution - Missense 38 7:55154119-55154119 + - PATHOGENIC .99273 Variant of unknown origin 28524162 surgery fresh/frozen NS 54 ENSP00000492462.1:p.Ser80Gly ENST00000638463.1:c.238A>G 7:g.55154119A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 UCHRP3 2682242 2541515 large_intestine NS NS NS other ulcerative_colitis dysplasia NS n COSV51844399 COSM6854571 174342219 c.1191C>A p.N397K Substitution - Missense 38 7:55165366-55165366 + - PATHOGENIC .87723 Variant of unknown origin 28524162 surgery fresh/frozen NS 54 ENSP00000492462.1:p.Asn397Lys ENST00000638463.1:c.1191C>A 7:g.55165366C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2862120 2862120 2717322 lung NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV105110976 COSM9572578 174329976 c.1013G>A p.G338D Substitution - Missense 38 7:55161631-55161631 + - PATHOGENIC .99386 Variant of unknown origin 31065835 surgery fresh/frozen NS ENSP00000492462.1:p.Gly338Asp ENST00000638463.1:c.1013G>A 7:g.55161631G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 SUPT1 1760532 1665135 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51819830 COSM327147 174333515 c.134G>A p.C45Y Substitution - Missense 38 7:55154015-55154015 + - PATHOGENIC .98182 Variant of unknown origin 22675565 cell-line NS ENSP00000492462.1:p.Cys45Tyr ENST00000638463.1:c.134G>A 7:g.55154015G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-55-7570-01 1914018 1802300 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51813309 COSM6178064 174386484 c.280G>A p.V94M Substitution - Missense 38 7:55155838-55155838 + - PATHOGENIC .97875 Variant of unknown origin 417 fresh/frozen - NOS primary 60 ENSP00000492462.1:p.Val94Met ENST00000638463.1:c.280G>A 7:g.55155838G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1194739 1194739 1106634 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51818096 COSM29341 174356716 c.1242C>G p.C414W Substitution - Missense 38 7:55165417-55165417 + - PATHOGENIC .989 Variant of unknown origin 19284481 surgery fresh/frozen primary ENSP00000492462.1:p.Cys414Trp ENST00000638463.1:c.1242C>G 7:g.55165417C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-08-0349-01 1910225 1798516 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51830791 COSM43068 174395561 c.359G>A p.C120Y Substitution - Missense het 38 7:55155917-55155917 + - PATHOGENIC .99356 Variant of unknown origin 329 fresh/frozen - NOS primary 46 ENSP00000492462.1:p.Cys120Tyr ENST00000638463.1:c.359G>A 7:g.55155917G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 LUAD_E01166 1765174 1669494 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51795467 COSM390866 174338740 c.91_92delinsTA p.A31Y Substitution - Missense 38 7:55152626-55152627 + - Variant of unknown origin 22980975 surgery - NOS primary ENSP00000492462.1:p.Ala31Tyr ENST00000638463.1:c.91_92delinsTA 7:g.55152626_55152627delinsTA EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2857410 2857410 2712710 skin NS NS NS malignant_melanoma NS NS NS n COSV51767869 COSM3266583 174321534 c.733C>T p.R245C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 31980996 surgery-fixed NS ENSP00000492462.1:p.Arg245Cys ENST00000638463.1:c.733C>T 7:g.55160191C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 LUAD-NYU408 1765248 1669568 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51855104 COSM374570 174331090 c.1103G>T p.R368L Substitution - Missense 38 7:55163822-55163822 + - PATHOGENIC .93703 Variant of unknown origin 22980975 surgery - NOS primary 71 ENSP00000492462.1:p.Arg368Leu ENST00000638463.1:c.1103G>T 7:g.55163822G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 AC-V16-Tumor-SM-9J46H 2584492 2445656 large_intestine anus NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51811313 COSM6008958 174321115 c.127C>G p.L43V Substitution - Missense 38 7:55152662-55152662 + - PATHOGENIC .95619 Variant of unknown origin 27852700 surgery-fixed recurrent ENSP00000492462.1:p.Leu43Val ENST00000638463.1:c.127C>G 7:g.55152662C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 PD42092a 2894833 2749321 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV105110933 COSM9881280 174364448 c.956C>T p.S319F Substitution - Missense 38 7:55161574-55161574 + - PATHOGENIC .96213 Variant of unknown origin 33024263 surgery-fixed metastasis 75 ENSP00000492462.1:p.Ser319Phe ENST00000638463.1:c.956C>T 7:g.55161574C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 LIM1215_R1_Cetux 2841367 2696923 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576981 COSM9396333 174378682 c.855A>G p.I285M Substitution - Missense 38 7:55160313-55160313 + - NEUTRAL .12443 Variant of unknown origin 25623215 cell-line NS ENSP00000492462.1:p.Ile285Met ENST00000638463.1:c.855A>G 7:g.55160313A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MBC032T 2807217 2663921 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99296355 COSM9120806 174385604 c.1037A>C p.N346T Substitution - Missense 38 7:55163756-55163756 + - PATHOGENIC .99524 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000492462.1:p.Asn346Thr ENST00000638463.1:c.1037A>C 7:g.55163756A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2626134 2626134 2486546 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51791433 COSM6191492 174383935 c.269_270delinsTT p.P90L Substitution - Missense 38 7:55154150-55154151 + - Variant of unknown origin 26645239 surgery-fixed NS ENSP00000492462.1:p.Pro90Leu ENST00000638463.1:c.269_270delinsTT 7:g.55154150_55154151delinsTT EGFR_ENST00000638463 ENST00000638463.1 1392 3236 VOA1947 2897843 2752142 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105864361 COSM9970409 174373174 c.352C>T p.R118C Substitution - Missense 38 7:55155910-55155910 + - PATHOGENIC .91299 Variant of unknown origin 31477716 surgery-fixed metastasis 69 ENSP00000492462.1:p.Arg118Cys ENST00000638463.1:c.352C>T 7:g.55155910C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-08-0246-01 1910219 1798510 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51792876 COSM43066 174324459 c.149A>C p.D50A Substitution - Missense hom 38 7:55154030-55154030 + - PATHOGENIC .98125 Variant of unknown origin 329 fresh/frozen - NOS primary 57 ENSP00000492462.1:p.Asp50Ala ENST00000638463.1:c.149A>C 7:g.55154030A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-02-0116-01 1910165 1798456 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51795519 COSM35822 174396361 c.1171G>C p.A391P Substitution - Missense hom 38 7:55165346-55165346 + - NEUTRAL .2004 Variant of unknown origin 329 fresh/frozen - NOS primary 54 ENSP00000492462.1:p.Ala391Pro ENST00000638463.1:c.1171G>C 7:g.55165346G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-78-7147-01 1914054 1802336 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51797369 COSM6178060 174370809 c.541C>A p.L181M Substitution - Missense 38 7:55156784-55156784 + - PATHOGENIC .85999 Variant of unknown origin 417 fresh/frozen - NOS primary 67 ENSP00000492462.1:p.Leu181Met ENST00000638463.1:c.541C>A 7:g.55156784C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NAN8 2809783 2666453 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV99289304 COSM9153919 174346929 c.52C>T p.R18C Substitution - Missense het 38 7:55152587-55152587 + - PATHOGENIC .90413 Variant of unknown origin 30545397 cell-line primary ENSP00000492462.1:p.Arg18Cys ENST00000638463.1:c.52C>T 7:g.55152587C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MBC531 2807310 2664014 breast NS NS NS carcinoma NS NS NS n COSV99286738 COSM9120811 174396702 c.601A>G p.I201V Substitution - Missense 38 7:55157674-55157674 + - PATHOGENIC .99284 Variant of unknown origin 31340200 surgery - NOS NS ENSP00000492462.1:p.Ile201Val ENST00000638463.1:c.601A>G 7:g.55157674A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 DM16 2466857 2329688 skin head_neck NS NS malignant_melanoma desmoplastic NS NS n COSV51842833 COSM5608338 174366823 c.176C>T p.P59L Substitution - Missense 38 7:55154057-55154057 + - PATHOGENIC .98876 Variant of unknown origin 26343386 surgery-fixed NS 80 ENSP00000492462.1:p.Pro59Leu ENST00000638463.1:c.176C>T 7:g.55154057C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00226T00226 2857365 2712665 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 174349213 c.544G>A p.D182N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000492462.1:p.Asp182Asn ENST00000638463.1:c.544G>A 7:g.55156787G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2585427 2585427 2446591 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51767869 COSM3266583 174321534 c.733C>T p.R245C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 25623215 surgery - NOS recurrent ENSP00000492462.1:p.Arg245Cys ENST00000638463.1:c.733C>T 7:g.55160191C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 H1793 2776325 2634461 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51866889 COSM3266567 174333498 c.314G>T p.C105F Substitution - Missense 38 7:55155872-55155872 + - PATHOGENIC .99418 Variant of unknown origin 29681454 NS NS 52 ENSP00000492462.1:p.Cys105Phe ENST00000638463.1:c.314G>T 7:g.55155872G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2 2557184 2418609 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51828150 COSM5976431 174323250 c.937G>A p.E313K Substitution - Missense 38 7:55161555-55161555 + - PATHOGENIC .8557 Variant of unknown origin 26934577 surgery fresh/frozen NS ENSP00000492462.1:p.Glu313Lys ENST00000638463.1:c.937G>A 7:g.55161555G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GBC_6 2907852 2762035 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV105864473 COSM10029109 174377489 c.742A>G p.K248E Substitution - Missense 38 7:55160200-55160200 + - PATHOGENIC .95086 Variant of unknown origin 33563892 surgery-fixed NS 85 ENSP00000492462.1:p.Lys248Glu ENST00000638463.1:c.742A>G 7:g.55160200A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 ESO-721 1890961 1780330 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV51788608 COSM1251016 174337144 c.722C>A p.S241Y Substitution - Missense 38 7:55160180-55160180 + - .5293 Variant of unknown origin 23525077 surgery fresh/frozen primary 68 ENSP00000492462.1:p.Ser241Tyr ENST00000638463.1:c.722C>A 7:g.55160180C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 DM10 2466851 2329682 skin face NS NS malignant_melanoma desmoplastic NS NS n COSV51850876 COSM5608334 174336113 c.739C>T p.L247F Substitution - Missense 38 7:55160197-55160197 + - PATHOGENIC .96542 Variant of unknown origin 26343386 surgery-fixed NS 70 ENSP00000492462.1:p.Leu247Phe ENST00000638463.1:c.739C>T 7:g.55160197C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 DM51 2466875 2329706 skin neck NS NS malignant_melanoma desmoplastic NS NS n COSV51774157 COSM5608355 174366156 c.1188A>T p.E396D Substitution - Missense 38 7:55165363-55165363 + - PATHOGENIC .71202 Variant of unknown origin 26343386 surgery-fixed NS 88 ENSP00000492462.1:p.Glu396Asp ENST00000638463.1:c.1188A>T 7:g.55165363A>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 174349213 c.544G>A p.D182N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000492462.1:p.Asp182Asn ENST00000638463.1:c.544G>A 7:g.55156787G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51841184 COSM1090877 174323691 c.1003C>A p.L335I Substitution - Missense het 38 7:55161621-55161621 + - NEUTRAL .01946 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000492462.1:p.Leu335Ile ENST00000638463.1:c.1003C>A 7:g.55161621C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 OX-CO-2_R2_Cetux 2841377 2696927 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576981 COSM9396333 174378682 c.855A>G p.I285M Substitution - Missense 38 7:55160313-55160313 + - NEUTRAL .12443 Variant of unknown origin 25623215 cell-line NS ENSP00000492462.1:p.Ile285Met ENST00000638463.1:c.855A>G 7:g.55160313A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 RDES 2294586 2160613 bone NS NS NS Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour NS NS NS y COSV51793186 COSM4587483 174367012 c.1180A>G p.M394V Substitution - Missense 38 7:55165355-55165355 + - PATHOGENIC .89999 Variant of unknown origin 25186949 cell-line NS ENSP00000492462.1:p.Met394Val ENST00000638463.1:c.1180A>G 7:g.55165355A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-273-tumor 2819121 2675420 meninges NS NS NS meningioma anaplastic NS NS n COSV104369217 COSM9267459 174354827 c.796G>A p.A266T Substitution - Missense 38 7:55160254-55160254 + - PATHOGENIC .94147 Variant of unknown origin 28713588 surgery - NOS NS ENSP00000492462.1:p.Ala266Thr ENST00000638463.1:c.796G>A 7:g.55160254G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TMIT_I_12 2765652 2623896 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV99034441 COSM7346604 174327621 c.505G>A p.A169T Substitution - Missense 38 7:55156649-55156649 + - PATHOGENIC .97686 Variant of unknown origin 30239046 surgery-fixed NS ENSP00000492462.1:p.Ala169Thr ENST00000638463.1:c.505G>A 7:g.55156649G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732917 2732917 2591670 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827197 COSM7002281 174364269 c.1166G>A p.C389Y Substitution - Missense 38 7:55165341-55165341 + - PATHOGENIC .99683 Variant of unknown origin 28855349 surgery - NOS primary 39 ENSP00000492462.1:p.Cys389Tyr ENST00000638463.1:c.1166G>A 7:g.55165341G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 DM26 2466862 2329693 skin scalp NS NS malignant_melanoma desmoplastic NS NS n COSV51820811 COSM5611257 174372451 c.1170_1171delinsAA p.A391T Substitution - Missense 38 7:55165345-55165346 + - Variant of unknown origin 26343386 surgery-fixed NS 79 ENSP00000492462.1:p.Ala391Thr ENST00000638463.1:c.1170_1171delinsAA 7:g.55165345_55165346delinsAA EGFR_ENST00000638463 ENST00000638463.1 1392 3236 DM17 2466858 2329689 skin arm NS NS malignant_melanoma desmoplastic NS NS n COSV51804378 COSM5608346 174373500 c.940C>T p.P314S Substitution - Missense 38 7:55161558-55161558 + - PATHOGENIC .7492 Variant of unknown origin 26343386 surgery-fixed NS 74 ENSP00000492462.1:p.Pro314Ser ENST00000638463.1:c.940C>T 7:g.55161558C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00389T00389 2857373 2712673 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 174349213 c.544G>A p.D182N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000492462.1:p.Asp182Asn ENST00000638463.1:c.544G>A 7:g.55156787G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-144-tumor 2819049 2675348 meninges NS NS NS meningioma atypical NS NS n COSV104369075 COSM9267309 174345590 c.1198C>G p.L400V Substitution - Missense 38 7:55165373-55165373 + - PATHOGENIC .90295 Variant of unknown origin 28713588 surgery - NOS NS ENSP00000492462.1:p.Leu400Val ENST00000638463.1:c.1198C>G 7:g.55165373C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 LPS3 2800446 2657262 soft_tissue fat NS NS liposarcoma well_differentiated NS NS n COSV99289299 COSM9110946 174358918 c.631C>T p.L211F Substitution - Missense 38 7:55157704-55157704 + - PATHOGENIC .98762 Variant of unknown origin 26643872 surgery - NOS primary ENSP00000492462.1:p.Leu211Phe ENST00000638463.1:c.631C>T 7:g.55157704C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 K5B66H 2762307 2620566 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51767869 COSM3266583 174321534 c.733C>T p.R245C Substitution - Missense 38 7:55160191-55160191 + - PATHOGENIC .9747 Variant of unknown origin 29615459 NS primary 42 ENSP00000492462.1:p.Arg245Cys ENST00000638463.1:c.733C>T 7:g.55160191C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-176-tumor 2819069 2675368 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732608 2732608 2591361 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779091 COSM2155593 174333195 c.470C>T p.T157I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Reported in another cancer sample as somatic 26757882 surgery-fixed primary 57 ENSP00000492462.1:p.Thr157Ile ENST00000638463.1:c.470C>T 7:g.55156614C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 CCK-81_R1_Cetux 2841357 2696917 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 174335092 c.773C>T p.S258L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000492462.1:p.Ser258Leu ENST00000638463.1:c.773C>T 7:g.55160231C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2579678 2579678 2441015 NS NS NS NS malignant_melanoma NS NS NS n COSV51769129 COSM6005742 174341372 c.1183_1184delinsAA p.G395K Substitution - Missense 38 7:55165358-55165359 + - Variant of unknown origin 25148578 surgery-fixed NS ENSP00000492462.1:p.Gly395Lys ENST00000638463.1:c.1183_1184delinsAA 7:g.55165358_55165359delinsAA EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00196T00196 2857366 2712666 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 BL-17-E51214 2905659 2759915 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864645 COSM9997785 174393308 c.1103G>A p.R368Q Substitution - Missense 38 7:55163822-55163822 + - PATHOGENIC .88204 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000492462.1:p.Arg368Gln ENST00000638463.1:c.1103G>A 7:g.55163822G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 AC-V10-Tumor-SM-9J465 2584480 2445644 large_intestine anus NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51802062 COSM6008937 174330535 c.41C>T p.S14F Substitution - Missense 38 7:55152576-55152576 + - PATHOGENIC .98424 Variant of unknown origin 27852700 surgery-fixed primary ENSP00000492462.1:p.Ser14Phe ENST00000638463.1:c.41C>T 7:g.55152576C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732913 2732913 2591666 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 174320891 c.248C>A p.A83D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 60 ENSP00000492462.1:p.Ala83Asp ENST00000638463.1:c.248C>A 7:g.55154129C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-264-tumor 2819115 2675414 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2509044 2509044 2371379 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 49 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-061-tumor 2819000 2675299 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2808101 2808101 2664786 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 31258848 surgery-fixed NS 60 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00229T00229 2857347 2712647 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-02-0023-01 1910131 1798422 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 38 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-081-tumor 2819015 2675314 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-116-tumor 2819038 2675337 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 SA-N101 2521507 2383850 central_nervous_system spinal_cord NS NS glioma astrocytoma_Grade_II fibrillary NS n COSV51785554 COSM21688 174319529 c.353G>T p.R118L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Reported in another cancer sample as somatic 26487540 surgery-fixed NS 82 ENSP00000492462.1:p.Arg118Leu ENST00000638463.1:c.353G>T 7:g.55155911G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 BL-17-W08054 2905635 2759891 urinary_tract NS NS NS carcinoma transitional_cell_carcinoma NS NS n COSV105863907 COSM9995468 174339737 c.1106G>A p.G369E Substitution - Missense 38 7:55165281-55165281 + - PATHOGENIC .99217 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000492462.1:p.Gly369Glu ENST00000638463.1:c.1106G>A 7:g.55165281G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-AP-A051-01 1783330 1687329 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51848796 COSM1090874 174333576 c.703G>A p.V235I Substitution - Missense het 38 7:55160161-55160161 + - PATHOGENIC .92435 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000492462.1:p.Val235Ile ENST00000638463.1:c.703G>A 7:g.55160161G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0002PT00040T00040 2857344 2712644 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-38-4629-01 1780093 1684092 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51776247 COSM6110417 174336954 c.775G>A p.G259R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 68 ENSP00000492462.1:p.Gly259Arg ENST00000638463.1:c.775G>A 7:g.55160233G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-194-tumor 2819079 2675378 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-209-tumor 2819091 2675390 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 S001097 1027690 944666 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 174320891 c.248C>A p.A83D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000492462.1:p.Ala83Asp ENST00000638463.1:c.248C>A 7:g.55154129C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 LUAD-RT-S01702 1765245 1669565 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51797291 COSM379422 174363418 c.1279C>T p.L427F Substitution - Missense 38 7:55171191-55171191 + - PATHOGENIC .94672 Variant of unknown origin 22980975 surgery - NOS primary 60 ENSP00000492462.1:p.Leu427Phe ENST00000638463.1:c.1279C>T 7:g.55171191C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-270-tumor 2819119 2675418 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 BL-18-T40375 2905680 2759936 NS NS NS NS malignant_melanoma NS NS NS n COSV105864576 COSM9994315 174383486 c.917C>T p.P306L Substitution - Missense 38 7:55161535-55161535 + - NEUTRAL .20165 Variant of unknown origin 32321774 surgery-fixed metastasis ENSP00000492462.1:p.Pro306Leu ENST00000638463.1:c.917C>T 7:g.55161535C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-05-4410-01 1780064 1684063 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51823181 COSM6110421 174358160 c.513G>T p.R171S Substitution - Missense 38 7:55156657-55156657 + - NEUTRAL .42615 Variant of unknown origin 417 fresh/frozen - NOS primary 62 ENSP00000492462.1:p.Arg171Ser ENST00000638463.1:c.513G>T 7:g.55156657G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-089-tumor 2819020 2675319 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 LIM1215_R5_Cetux 2841371 2696923 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51776247 COSM6110417 174336954 c.775G>A p.G259R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000492462.1:p.Gly259Arg ENST00000638463.1:c.775G>A 7:g.55160233G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2509057 2509057 2371392 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51783296 COSM5878511 174366869 c.43G>T p.G15W Substitution - Missense 38 7:55152578-55152578 + - NEUTRAL .4823 Variant of unknown origin 26919320 surgery - NOS NS 43 ENSP00000492462.1:p.Gly15Trp ENST00000638463.1:c.43G>T 7:g.55152578G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-189-tumor 2819075 2675374 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-12-0616-01 1910246 1798537 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 36 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51803429 COSM7002279 174329888 c.662G>A p.R221H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000492462.1:p.Arg221His ENST00000638463.1:c.662G>A 7:g.55157735G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-246-tumor 2819109 2675408 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-073-tumor 2819009 2675308 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00329T00329 2857335 2712635 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2819307 2819307 2675606 lung left_upper_lobe NS NS carcinoma invasive_mucinous_adenocarcinoma NS NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 30572543 circulating tumour NS 80 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 109600 2812903 2669317 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 46 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-150-tumor 2819055 2675354 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00300T00300 2857355 2712655 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 EGCT1088 2490716 2353365 testis NS NS NS germ_cell_tumour choriocarcinoma NS NS n COSV51835294 COSM5749118 174358552 c.1105G>A p.G369R Substitution - Missense 38 7:55165280-55165280 + - PATHOGENIC .99792 Variant of unknown origin 26956871 surgery fresh/frozen primary ENSP00000492462.1:p.Gly369Arg ENST00000638463.1:c.1105G>A 7:g.55165280G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-043-tumor 2818993 2675292 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00005T00005 2857374 2712674 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00296T00296 2857351 2712651 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732920 2732920 2591673 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 174322412 c.169A>C p.T57P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 73 ENSP00000492462.1:p.Thr57Pro ENST00000638463.1:c.169A>C 7:g.55154050A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00177T00177 2857368 2712668 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00204T00204 2857356 2712656 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-103-tumor 2819029 2675328 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732919 2732919 2591672 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 174322412 c.169A>C p.T57P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 73 ENSP00000492462.1:p.Thr57Pro ENST00000638463.1:c.169A>C 7:g.55154050A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1194729 1194729 1106624 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2509042 2509042 2371377 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 174322412 c.169A>C p.T57P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 74 ENSP00000492462.1:p.Thr57Pro ENST00000638463.1:c.169A>C 7:g.55154050A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0127-01 1910170 1798461 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766389 COSM43067 174346864 c.256G>T p.V86L Substitution - Missense het 38 7:55154137-55154137 + - PATHOGENIC .98997 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 67 ENSP00000492462.1:p.Val86Leu ENST00000638463.1:c.256G>T 7:g.55154137G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-042-tumor 2818992 2675291 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-160-tumor 2819059 2675358 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00331T00331 2857371 2712671 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-104-tumor 2819030 2675329 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-228-tumor 2819103 2675402 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-076-tumor 2819012 2675311 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 109588 2812897 2669311 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 45 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-AB-2878-03 1650370 1565157 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV51771306 COSM1318972 174335686 c.1295C>T p.T432M Substitution - Missense het 38 7:55171207-55171207 + - NEUTRAL .03249 Reported in another cancer sample as somatic 377 blood-bone marrow NS 47 ENSP00000492462.1:p.Thr432Met ENST00000638463.1:c.1295C>T 7:g.55171207C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-205-tumor 2819087 2675386 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00332T00332 2857343 2712643 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2855910 2855910 2711313 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV104368998 COSM9232920 174336611 c.268C>T p.P90S Substitution - Missense 38 7:55154149-55154149 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 32269842 surgery-fixed NS 58 ENSP00000492462.1:p.Pro90Ser ENST00000638463.1:c.268C>T 7:g.55154149C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 BL-16-G30012 2905599 2759855 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51815598 COSM6471954 174337590 c.707G>T p.S236I Substitution - Missense 38 7:55160165-55160165 + - NEUTRAL .44157 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000492462.1:p.Ser236Ile ENST00000638463.1:c.707G>T 7:g.55160165G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732886 2732886 2591639 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779091 COSM2155593 174333195 c.470C>T p.T157I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 50 ENSP00000492462.1:p.Thr157Ile ENST00000638463.1:c.470C>T 7:g.55156614C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-099-tumor 2819026 2675325 meninges NS NS NS meningioma fibroblastic NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-266-tumor 2819117 2675416 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 SJHYPO052 2301072 2166353 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 174325727 c.661C>T p.R221C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Reported in another cancer sample as somatic 638 NS NS ENSP00000492462.1:p.Arg221Cys ENST00000638463.1:c.661C>T 7:g.55157734C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0157-01 1910184 1798475 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 63 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 LUAD-NYU608 1765135 1669455 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51772147 COSM375343 174337812 c.1316C>G p.S439C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Reported in another cancer sample as somatic 22980975 surgery - NOS primary 64 ENSP00000492462.1:p.Ser439Cys ENST00000638463.1:c.1316C>G 7:g.55172997C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-112-tumor 2819035 2675334 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0002PT00013T00013 2857370 2712670 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00221T00221 2857376 2712676 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-125-tumor 2819044 2675343 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-027-tumor 2818987 2675286 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 109618 2812909 2669323 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 52 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00354T00354 2857354 2712654 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-02-0003-01 1910122 1798413 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51809225 COSM35825 174349814 c.1241G>A p.C414Y Substitution - Missense het 38 7:55165416-55165416 + - PATHOGENIC .99893 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 50 ENSP00000492462.1:p.Cys414Tyr ENST00000638463.1:c.1241G>A 7:g.55165416G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-147-tumor 2819052 2675351 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 109590 2812898 2669312 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 56 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732921 2732921 2591674 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 49 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0002PT00013T00013 2857370 2712670 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV99291226 COSM7552389 174347646 c.506C>T p.A169V Substitution - Missense 38 7:55156650-55156650 + - PATHOGENIC .98971 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Ala169Val ENST00000638463.1:c.506C>T 7:g.55156650C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0002PT00039T00039 2857325 2712625 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-78-7155-01 1914061 1802343 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51802828 COSM6178056 174396384 c.678A>T p.Q226H Substitution - Missense 38 7:55157751-55157751 + - PATHOGENIC .9647 Variant of unknown origin 417 fresh/frozen - NOS primary 68 ENSP00000492462.1:p.Gln226His ENST00000638463.1:c.678A>T 7:g.55157751A>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-024-tumor 2818985 2675284 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 LUAD-RT-S01810 1765179 1669499 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51809160 COSM382935 174322117 c.988G>A p.V330M Substitution - Missense 38 7:55161606-55161606 + - PATHOGENIC .98051 Reported in another cancer sample as somatic 22980975 surgery - NOS primary ENSP00000492462.1:p.Val330Met ENST00000638463.1:c.988G>A 7:g.55161606G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51803429 COSM7002279 174329888 c.662G>A p.R221H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000492462.1:p.Arg221His ENST00000638463.1:c.662G>A 7:g.55157735G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00357T00357 2857360 2712660 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732924 2732924 2591677 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 64 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-273-tumor 2819121 2675420 meninges NS NS NS meningioma anaplastic NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00320T00320 2857338 2712638 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-208-tumor 2819090 2675389 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-023-tumor 2818984 2675283 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732935 2732935 2591688 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 72 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-275-tumor 2819122 2675421 meninges NS NS NS meningioma anaplastic NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2509046 2509046 2371381 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 174318949 c.1169C>T p.P390L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 62 ENSP00000492462.1:p.Pro390Leu ENST00000638463.1:c.1169C>T 7:g.55165344C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00426T00426 2857346 2712646 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00346T00346 2857341 2712641 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00192T00192 2857326 2712626 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 109598 2812902 2669316 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 44 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-162-tumor 2819060 2675359 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 BL-14-R46791 2905653 2759909 NS NS NS NS malignant_melanoma NS NS NS n COSV51844648 COSM6971178 174327834 c.202A>G p.T68A Substitution - Missense 38 7:55154083-55154083 + - PATHOGENIC .96224 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000492462.1:p.Thr68Ala ENST00000638463.1:c.202A>G 7:g.55154083A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 DM2 2466860 2329691 skin face NS NS malignant_melanoma desmoplastic NS NS n COSV51781503 COSM5608352 174343339 c.1291C>T p.P431S Substitution - Missense 38 7:55171203-55171203 + - NEUTRAL .1586 Reported in another cancer sample as somatic 26343386 surgery-fixed NS 86 ENSP00000492462.1:p.Pro431Ser ENST00000638463.1:c.1291C>T 7:g.55171203C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2733228 2733228 2591981 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 174318949 c.1169C>T p.P390L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 61 ENSP00000492462.1:p.Pro390Leu ENST00000638463.1:c.1169C>T 7:g.55165344C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0002PT00038T00038 2857332 2712632 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00305T00305 2857328 2712628 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00278T00278 2857364 2712664 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-197-tumor 2819082 2675381 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 BL-16-A36234 2905681 2759937 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-46-3769-01 1781825 1685824 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51799159 COSM747427 174345260 c.1148C>T p.P383L Substitution - Missense 38 7:55165323-55165323 + - PATHOGENIC .95834 Reported in another cancer sample as somatic 418 fresh/frozen - NOS primary 57 ENSP00000492462.1:p.Pro383Leu ENST00000638463.1:c.1148C>T 7:g.55165323C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 8LFG8F 2762947 2621206 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51839851 COSM7340115 174347180 c.500C>A p.P167Q Substitution - Missense 38 7:55156644-55156644 + - PATHOGENIC .76649 Reported in another cancer sample as somatic 29615459 NS metastasis 45 ENSP00000492462.1:p.Pro167Gln ENST00000638463.1:c.500C>A 7:g.55156644C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1194728 1194728 1106623 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 109610 2812911 2669325 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 16 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00264T00264 2857327 2712627 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-018-tumor 2818983 2675282 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 DCR10 1690659 1598936 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 174333561 c.858C>A p.S286R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000492462.1:p.Ser286Arg ENST00000638463.1:c.858C>A 7:g.55160316C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0002PT00015T00015 2857336 2712636 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-02-0021-01 1910130 1798421 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 174325029 c.136C>T p.R46C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 44 ENSP00000492462.1:p.Arg46Cys ENST00000638463.1:c.136C>T 7:g.55154017C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00226T00226 2857365 2712665 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-087-tumor 2819019 2675318 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-185-tumor 2819071 2675370 meninges NS NS NS meningioma angiomatous NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-171-tumor 2819064 2675363 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00240T00240 2857369 2712669 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-168-tumor 2819062 2675361 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-083-tumor 2819016 2675315 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1194730 1194730 1106625 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 DCR7 1690657 1598934 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 174333561 c.858C>A p.S286R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000492462.1:p.Ser286Arg ENST00000638463.1:c.858C>A 7:g.55160316C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0008349-T01-IM5 2724478 2583299 haematopoietic_and_lymphoid_tissue lymph_node NS NS lymphoid_neoplasm angioimmunoblastic_T_cell_lymphoma NS NS n COSV51806667 COSM6987130 174343458 c.1321G>A p.A441T Substitution - Missense het 38 7:55173002-55173002 + - PATHOGENIC .99609 Reported in another cancer sample as somatic 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala441Thr ENST00000638463.1:c.1321G>A 7:g.55173002G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-AS-3778-01 1779806 1683805 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51831642 COSM1496684 174333100 c.370G>A p.E124K Substitution - Missense 38 7:55155928-55155928 + - PATHOGENIC .94538 Reported in another cancer sample as somatic 416 fresh/frozen - NOS primary 35 ENSP00000492462.1:p.Glu124Lys ENST00000638463.1:c.370G>A 7:g.55155928G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-066-tumor 2819004 2675303 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-014-tumor 2818981 2675280 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 S002024 1027695 944671 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51785554 COSM21688 174319529 c.353G>T p.R118L Substitution - Missense het 38 7:55155911-55155911 + - PATHOGENIC .97287 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000492462.1:p.Arg118Leu ENST00000638463.1:c.353G>T 7:g.55155911G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 B00426 2910515 2764377 ovary NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51792433 COSM6966446 174352434 c.1144G>A p.G382S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Reported in another cancer sample as somatic 33947352 surgery-fixed NS ENSP00000492462.1:p.Gly382Ser ENST00000638463.1:c.1144G>A 7:g.55165319G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-AP-A0LM-01 1783352 1687351 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51797307 COSM1090871 174341516 c.692C>A p.S231Y Substitution - Missense het 38 7:55160150-55160150 + - PATHOGENIC .98943 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 33 ENSP00000492462.1:p.Ser231Tyr ENST00000638463.1:c.692C>A 7:g.55160150C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-111-tumor 2819034 2675333 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00227T00227 2857348 2712648 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00414T00414 2857361 2712661 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-075-tumor 2819011 2675310 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 109596 2812901 2669315 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 72 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2696524 2696524 2555428 central_nervous_system middle_frontal_gyrus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28201779 surgery fresh/frozen NS 56 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00355T00355 2857331 2712631 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-174-tumor 2819067 2675366 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-230-tumor 2819105 2675404 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0154-01 1910182 1798473 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense hom 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 55 ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 618-1503-04TD 1921502 1808820 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51797215 COSM145360 174331056 c.349G>A p.V117I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Reported in another cancer sample as somatic 340 blood NS ENSP00000492462.1:p.Val117Ile ENST00000638463.1:c.349G>A 7:g.55155907G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-201-tumor 2819084 2675383 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0002PT00018T00018 2857363 2712663 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-121-tumor 2819042 2675341 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 ESO-963 1890976 1780345 oesophagus NS NS NS carcinoma adenocarcinoma NS NS y COSV51799199 COSM1251020 174325395 c.1156G>A p.V386I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Reported in another cancer sample as somatic 23525077 surgery fresh/frozen primary 75 ENSP00000492462.1:p.Val386Ile ENST00000638463.1:c.1156G>A 7:g.55165331G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2733218 2733218 2591971 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 42 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 S001005 1027699 944675 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2805811 2805811 2662548 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 31348837 surgery - NOS NS ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1194736 1194736 1106631 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1194725 1194725 1106620 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 174320891 c.248C>A p.A83D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000492462.1:p.Ala83Asp ENST00000638463.1:c.248C>A 7:g.55154129C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 OX-CO-2_R3_Cetux 2841378 2696927 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 174335092 c.773C>T p.S258L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Reported in another cancer sample as somatic 25623215 cell-line NS ENSP00000492462.1:p.Ser258Leu ENST00000638463.1:c.773C>T 7:g.55160231C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0125-01 1910168 1798459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 64 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00207T00207 2857359 2712659 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2625627 2625627 2486039 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51767687 COSM6191352 174317778 c.1129G>A p.A377T Substitution - Missense het 38 7:55165304-55165304 + - PATHOGENIC .98656 Reported in another cancer sample as somatic 26488212 surgery-fixed NS ENSP00000492462.1:p.Ala377Thr ENST00000638463.1:c.1129G>A 7:g.55165304G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2808102 2808102 2664786 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 31258848 surgery-fixed NS 60 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732896 2732896 2591649 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 58 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-156-tumor 2819056 2675355 meninges NS NS NS meningioma chordoid NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00143T00143 2857358 2712658 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00190T00190 2857342 2712642 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00243T00243 2857340 2712640 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2840788 2840788 2696348 prostate NS NS NS carcinoma NS NS NS n COSV51785413 COSM1176673 174327537 c.137G>A p.R46H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 31874108 surgery-fixed metastasis ENSP00000492462.1:p.Arg46His ENST00000638463.1:c.137G>A 7:g.55154018G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 SJHGG120_D 2307435 2172639 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 24705251 surgery - NOS NS 12 ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00383T00383 2857375 2712675 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-175-tumor 2819068 2675367 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 S001095 1027691 944667 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-02-0007-01 1910125 1798416 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 174322412 c.169A>C p.T57P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 42 ENSP00000492462.1:p.Thr57Pro ENST00000638463.1:c.169A>C 7:g.55154050A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-02-0089-01 1910158 1798449 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense hom 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 54 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 5-GE101-T1 2869805 2724802 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51822498 COSM3266565 174354571 c.299C>T p.S100L Substitution - Missense 38 7:55155857-55155857 + - PATHOGENIC .98807 Reported in another cancer sample as somatic 26950094 surgery - NOS NS 81 ENSP00000492462.1:p.Ser100Leu ENST00000638463.1:c.299C>T 7:g.55155857C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1194737 1194737 1106632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-RR-A6KC-01 2339255 2204238 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 174325029 c.136C>T p.R46C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 NS primary 55 ENSP00000492462.1:p.Arg46Cys ENST00000638463.1:c.136C>T 7:g.55154017C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-02-0016-01 1910129 1798420 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 50 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-078-tumor 2819014 2675313 meninges NS NS NS meningioma transitional NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-057-tumor 2818998 2675297 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0004119-T01-IM5 2720520 2579341 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 174325029 c.136C>T p.R46C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Arg46Cys ENST00000638463.1:c.136C>T 7:g.55154017C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 pros_01_dx 2688203 2547185 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm acute_myeloid_leukaemia NS NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 544 NS primary 41 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00443T00443 2857349 2712649 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-050-tumor 2818996 2675295 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-08-0380-01 1910239 1798530 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779162 COSM21689 174318949 c.1169C>T p.P390L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 74 ENSP00000492462.1:p.Pro390Leu ENST00000638463.1:c.1169C>T 7:g.55165344C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0004491-T01-IM5 2720890 2579711 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28481359 surgery - NOS primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 HN_62995 1560583 1482033 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825459 COSM122789 174330852 c.805A>G p.I269V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Reported in another cancer sample as somatic 21798893 surgery fresh/frozen primary ENSP00000492462.1:p.Ile269Val ENST00000638463.1:c.805A>G 7:g.55160263A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 S001067 1027687 944663 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 174322412 c.169A>C p.T57P Substitution - Missense hom 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000492462.1:p.Thr57Pro ENST00000638463.1:c.169A>C 7:g.55154050A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 924777 924777 841550 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51863722 COSM13560 174338824 c.1253G>T p.C418F Substitution - Missense het 38 7:55165428-55165428 + - PATHOGENIC .99905 Reported in another cancer sample as somatic 16133419 NS NS ENSP00000492462.1:p.Cys418Phe ENST00000638463.1:c.1253G>T 7:g.55165428G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 EXTERN_MELA_20140526_088 2839362 2695128 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 174324320 c.550C>A p.Q184K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000492462.1:p.Gln184Lys ENST00000638463.1:c.550C>A 7:g.55156793C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 T155 1861137 1752078 endometrium NS NS NS carcinoma serous_carcinoma NS NS y COSV51785413 COSM1176673 174327537 c.137G>A p.R46H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 23104009 surgery fresh/frozen primary ENSP00000492462.1:p.Arg46His ENST00000638463.1:c.137G>A 7:g.55154018G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-12-0829-01 2178136 2046434 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772147 COSM375343 174337812 c.1316C>G p.S439C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Confirmed somatic variant 329 NS NS 75 ENSP00000492462.1:p.Ser439Cys ENST00000638463.1:c.1316C>G 7:g.55172997C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-196-tumor 2819081 2675380 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2733227 2733227 2591980 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 174318949 c.1169C>T p.P390L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 61 ENSP00000492462.1:p.Pro390Leu ENST00000638463.1:c.1169C>T 7:g.55165344C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00237T00237 2857324 2712624 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 S001108 1027693 944669 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 17177598 cell-line NS ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732912 2732912 2591665 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 174320891 c.248C>A p.A83D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 60 ENSP00000492462.1:p.Ala83Asp ENST00000638463.1:c.248C>A 7:g.55154129C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2841857 2841857 2697406 soft_tissue fibrous_tissue_and_uncertain_origin trunk NS desmoid_tumour-fibromatosis NS NS NS n COSV51777833 COSM4680394 174328588 c.962G>A p.R321Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Reported in another cancer sample as somatic 32099073 surgery-fixed NS 27 ENSP00000492462.1:p.Arg321Gln ENST00000638463.1:c.962G>A 7:g.55161580G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-070-tumor 2819006 2675305 meninges NS NS NS meningioma meningothelial NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00173T00173 2857372 2712672 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1194731 1194731 1106626 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-02-0046-01 1910140 1798431 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 61 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0649 2107982 1985843 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51791901 COSM2151461 174357400 c.373G>A p.G125R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .96902 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Gly125Arg ENST00000638463.1:c.373G>A 7:g.55155931G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0185-01 1910194 1798485 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774819 COSM35840 174322963 c.1333G>A p.V445M Substitution - Missense het 38 7:55173014-55173014 + - PATHOGENIC .99458 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 54 ENSP00000492462.1:p.Val445Met ENST00000638463.1:c.1333G>A 7:g.55173014G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 PF08 2560049 2421473 large_intestine colon sigmoid NS adenoma tubular NS NS n COSV51779162 COSM21689 174318949 c.1169C>T p.P390L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Reported in another cancer sample as somatic 27609830 surgery-fixed NS ENSP00000492462.1:p.Pro390Leu ENST00000638463.1:c.1169C>T 7:g.55165344C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 109594 2812900 2669314 meninges NS NS NS meningioma NS NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 31470906 surgery fresh/frozen NS 66 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00004T00004 2857337 2712637 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2840787 2840787 2696347 prostate NS NS NS carcinoma NS NS NS n COSV51785413 COSM1176673 174327537 c.137G>A p.R46H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000492462.1:p.Arg46His ENST00000638463.1:c.137G>A 7:g.55154018G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00178T00178 2857362 2712662 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MG-198-tumor 2819083 2675382 meninges NS NS NS meningioma atypical NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28713588 surgery - NOS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732934 2732934 2591687 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 72 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2585421 2585421 2446585 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576891 COSM9396331 174334548 c.782A>C p.K261T Substitution - Missense het 38 7:55160240-55160240 + - NEUTRAL .10442 Reported in another cancer sample as somatic 25623215 surgery - NOS recurrent ENSP00000492462.1:p.Lys261Thr ENST00000638463.1:c.782A>C 7:g.55160240A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 DCR9 1690658 1598935 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 174333561 c.858C>A p.S286R Substitution - Missense het 38 7:55160316-55160316 + - NEUTRAL .35843 Reported in another cancer sample as somatic 22270724 cell-line NS ENSP00000492462.1:p.Ser286Arg ENST00000638463.1:c.858C>A 7:g.55160316C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732925 2732925 2591678 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 75 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2732923 2732923 2591676 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 64 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 CSCC-40-T 2292477 2158541 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51858853 COSM4512041 174373367 c.271C>T p.R91C Substitution - Missense het 38 7:55154152-55154152 + - PATHOGENIC .97012 Confirmed somatic variant 25303977 surgery fresh/frozen metastasis 49 ENSP00000492462.1:p.Arg91Cys ENST00000638463.1:c.271C>T 7:g.55154152C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-DU-7012-01 2194261 2062539 central_nervous_system brain NS NS glioma NS NS NS y COSV51774829 COSM1451549 174320530 c.149A>G p.D50G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 545 NS NS 74 ENSP00000492462.1:p.Asp50Gly ENST00000638463.1:c.149A>G 7:g.55154030A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2841184 2841184 2696744 prostate NS NS NS carcinoma NS NS NS n COSV104577128 COSM9497116 174379771 c.853A>G p.I285V Substitution - Missense 38 7:55160311-55160311 + - NEUTRAL .12941 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000492462.1:p.Ile285Val ENST00000638463.1:c.853A>G 7:g.55160311A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1194738 1194738 1106633 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 112509 1520625 1443000 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51833788 COSM94181 174371888 c.1057C>T p.H353Y Substitution - Missense 38 7:55163776-55163776 + - PATHOGENIC .97598 Confirmed somatic variant 20668451 NS primary ENSP00000492462.1:p.His353Tyr ENST00000638463.1:c.1057C>T 7:g.55163776C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GBM19-I1 2813465 2669857 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GB013T 2633978 2494374 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51855854 COSM6355744 174358321 c.359G>T p.C120F Substitution - Missense 38 7:55155917-55155917 + - PATHOGENIC .99445 Confirmed somatic variant 672 NS primary ENSP00000492462.1:p.Cys120Phe ENST00000638463.1:c.359G>T 7:g.55155917G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 U373 2491105 2353751 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51804471 COSM5712404 174398638 c.905C>T p.A302V Substitution - Missense 38 7:55161523-55161523 + - NEUTRAL .21884 Confirmed somatic variant 26496030 cell-line NS ENSP00000492462.1:p.Ala302Val ENST00000638463.1:c.905C>T 7:g.55161523C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0007024-T01-IM5 2723398 2582219 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51786507 COSM6955643 174356069 c.500C>T p.P167L Substitution - Missense het 38 7:55156644-55156644 + - PATHOGENIC .86501 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Pro167Leu ENST00000638463.1:c.500C>T 7:g.55156644C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0007024-T01-IM5 2723398 2582219 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 5-VS033-T2 2869855 2724852 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51790737 COSM3639739 174374628 c.1003C>T p.L335F Substitution - Missense 38 7:55161621-55161621 + - NEUTRAL .0484 Confirmed somatic variant 26950094 surgery - NOS NS 73 ENSP00000492462.1:p.Leu335Phe ENST00000638463.1:c.1003C>T 7:g.55161621C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-HC-7075-01 2121474 1995710 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51805358 COSM3674958 174367245 c.1336G>T p.G446W Substitution - Missense 38 7:55173017-55173017 + - PATHOGENIC .99788 Confirmed somatic variant 435 NS NS 63 ENSP00000492462.1:p.Gly446Trp ENST00000638463.1:c.1336G>T 7:g.55173017G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NPC0001PT00407T00407 2857330 2712630 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GB051T 2634016 2494412 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51846120 COSM6354678 174387104 c.1355T>A p.L452Q Substitution - Missense 38 7:55173036-55173036 + - PATHOGENIC .99616 Confirmed somatic variant 672 NS primary ENSP00000492462.1:p.Leu452Gln ENST00000638463.1:c.1355T>A 7:g.55173036T>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 S004384 1027694 944670 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0012113-T01-IM5 2727253 2586074 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51851189 COSM6982714 174335646 c.787T>G p.L263V Substitution - Missense het 38 7:55160245-55160245 + - NEUTRAL .32338 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Leu263Val ENST00000638463.1:c.787T>G 7:g.55160245T>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-14-0813-01 1337991 1248376 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779162 COSM21689 174318949 c.1169C>T p.P390L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 329 surgery fresh/frozen NS 78 ENSP00000492462.1:p.Pro390Leu ENST00000638463.1:c.1169C>T 7:g.55165344C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 400_R4 2910227 2764189 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV104577128 COSM9497116 174379771 c.853A>G p.I285V Substitution - Missense het 38 7:55160311-55160311 + - NEUTRAL .12941 Confirmed somatic variant 27639803 short-term culture NS 69 ENSP00000492462.1:p.Ile285Val ENST00000638463.1:c.853A>G 7:g.55160311A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GB057T 2634022 2494418 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 672 NS primary ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-FG-6692-01 2194411 2062689 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 63 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 non-ocular_carcinoma_3 2580640 2441977 skin neck NS NS adnexal_tumour sebaceous_carcinoma NS NS n COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 27287813 surgery-fixed primary ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-16-1045-01 1338027 1248412 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 174322412 c.169A>C p.T57P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 surgery fresh/frozen NS 49 ENSP00000492462.1:p.Thr57Pro ENST00000638463.1:c.169A>C 7:g.55154050A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0002124-T01-IM3 2718419 2577240 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51806564 COSM6920868 174327986 c.1388G>A p.R463Q Substitution - Missense het 38 7:55173069-55173069 + - PATHOGENIC .99699 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Arg463Gln ENST00000638463.1:c.1388G>A 7:g.55173069G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-DF-A2L0-01 2457392 2320229 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51809160 COSM382935 174322117 c.988G>A p.V330M Substitution - Missense 38 7:55161606-55161606 + - PATHOGENIC .98051 Confirmed somatic variant 419 NS primary 60 ENSP00000492462.1:p.Val330Met ENST00000638463.1:c.988G>A 7:g.55161606G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0000677-T01-IM3 2715765 2574586 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51860516 COSM6911906 174344120 c.525C>G p.F175L Substitution - Missense het 38 7:55156768-55156768 + - PATHOGENIC .96387 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Phe175Leu ENST00000638463.1:c.525C>G 7:g.55156768C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 ICGC_GBM53_tumor 2634861 2495257 central_nervous_system brain NS NS primitive_neuroectodermal_tumour-medulloblastoma NS NS NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 379 NS primary 5 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 174320891 c.248C>A p.A83D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000492462.1:p.Ala83Asp ENST00000638463.1:c.248C>A 7:g.55154129C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51807036 COSM2151966 174334262 c.1169C>G p.P390R Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99615 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000492462.1:p.Pro390Arg ENST00000638463.1:c.1169C>G 7:g.55165344C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0009856-T01-IM5 2725695 2584516 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51844648 COSM6971178 174327834 c.202A>G p.T68A Substitution - Missense het 38 7:55154083-55154083 + - PATHOGENIC .96224 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000492462.1:p.Thr68Ala ENST00000638463.1:c.202A>G 7:g.55154083A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 004 2492942 2355556 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour benign NS n COSV51768130 COSM21684 174322412 c.169A>C p.T57P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 26437033 NS NS ENSP00000492462.1:p.Thr57Pro ENST00000638463.1:c.169A>C 7:g.55154050A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-12-3652-01 2120285 1994521 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51800797 COSM3412178 174330193 c.137G>C p.R46P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 329 NS NS 60 ENSP00000492462.1:p.Arg46Pro ENST00000638463.1:c.137G>C 7:g.55154018G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0013374-T01-IM5 2803847 2660597 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51793336 COSM6214981 174356977 c.1045T>C p.C349R Substitution - Missense het 38 7:55163764-55163764 + - PATHOGENIC .99407 Confirmed somatic variant 29316426 surgery-fixed primary 79 ENSP00000492462.1:p.Cys349Arg ENST00000638463.1:c.1045T>C 7:g.55163764T>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003104-T01-IM5 2719600 2578421 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51779162 COSM21689 174318949 c.1169C>T p.P390L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Pro390Leu ENST00000638463.1:c.1169C>T 7:g.55165344C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0749-01 1337861 1248246 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849279 COSM6923107 174324747 c.1152C>A p.H384Q Substitution - Missense het 38 7:55165327-55165327 + - PATHOGENIC .98427 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.His384Gln ENST00000638463.1:c.1152C>A 7:g.55165327C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849240 COSM6923103 174324727 c.1141G>A p.D381N Substitution - Missense het 38 7:55165316-55165316 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Asp381Asn ENST00000638463.1:c.1141G>A 7:g.55165316G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0000657-T01-IM3 2715718 2574539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849201 COSM6923099 174324694 c.713A>T p.N238I Substitution - Missense het 38 7:55160171-55160171 + - PATHOGENIC .8398 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Asn238Ile ENST00000638463.1:c.713A>T 7:g.55160171A>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-19-2620-01 2120303 1994539 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 70 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 S02279_1 2480887 2343632 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV51810698 COSM5683869 174350445 c.719C>A p.T240K Substitution - Missense 38 7:55160177-55160177 + - NEUTRAL .09422 Confirmed somatic variant 26168399 surgery fresh/frozen primary 58 ENSP00000492462.1:p.Thr240Lys ENST00000638463.1:c.719C>A 7:g.55160177C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0004971-T01-IM5 2721381 2580202 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 PD6907a 1504118 1426996 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51857264 COSM4384115 174368758 c.109C>T p.P37S Substitution - Missense 38 7:55152644-55152644 + - PATHOGENIC .99273 Confirmed somatic variant 24030381 NS NS ENSP00000492462.1:p.Pro37Ser ENST00000638463.1:c.109C>T 7:g.55152644C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 R098-I1 2813503 2669895 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 174323026 c.191A>G p.Y64C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 28263318 surgery fresh/frozen NS 51 ENSP00000492462.1:p.Tyr64Cys ENST00000638463.1:c.191A>G 7:g.55154072A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-FP-7829-01 2198081 2066359 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51829933 COSM3881812 174342700 c.353G>A p.R118H Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .95186 Confirmed somatic variant 541 NS NS 69 ENSP00000492462.1:p.Arg118His ENST00000638463.1:c.353G>A 7:g.55155911G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GBM19-I2 2813466 2669858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0004846-T01-IM5 2721249 2580070 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51779091 COSM2155593 174333195 c.470C>T p.T157I Substitution - Missense het 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000492462.1:p.Thr157Ile ENST00000638463.1:c.470C>T 7:g.55156614C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 LC_S35 1863746 1754637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 22975805 surgery fresh/frozen primary 82 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 A-2A 2746111 2604814 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51851236 COSM7304351 174368196 c.1273C>T p.P425S Substitution - Missense 38 7:55171185-55171185 + - PATHOGENIC .97683 Confirmed somatic variant 646 NS primary 20 ENSP00000492462.1:p.Pro425Ser ENST00000638463.1:c.1273C>T 7:g.55171185C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003222-T01-IM5 2719716 2578537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51841941 COSM6927106 174321230 c.228G>T p.E76D Substitution - Missense het 38 7:55154109-55154109 + - NEUTRAL .06117 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000492462.1:p.Glu76Asp ENST00000638463.1:c.228G>T 7:g.55154109G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-19-1789 2108040 1985901 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51850088 COSM2156010 174345239 c.382C>T p.R128C Substitution - Missense 38 7:55155940-55155940 + - PATHOGENIC .91604 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Arg128Cys ENST00000638463.1:c.382C>T 7:g.55155940C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-02-0003 2107930 1985791 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51809225 COSM35825 174349814 c.1241G>A p.C414Y Substitution - Missense 38 7:55165416-55165416 + - PATHOGENIC .99893 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Cys414Tyr ENST00000638463.1:c.1241G>A 7:g.55165416G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0000906-T01-IM3 2716233 2575054 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765787 COSM2149971 174321914 c.292C>T p.H98Y Substitution - Missense het 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.His98Tyr ENST00000638463.1:c.292C>T 7:g.55155850C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 LICA-CN-HCC089T 2634136 2494532 liver NS NS NS other neoplasm NS NS y COSV51832020 COSM5822378 174351656 c.1124A>T p.Q375L Substitution - Missense 38 7:55165299-55165299 + - PATHOGENIC .9451 Confirmed somatic variant 660 NS primary 48 ENSP00000492462.1:p.Gln375Leu ENST00000638463.1:c.1124A>T 7:g.55165299A>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-QH-A6CX-01 2263100 2130084 central_nervous_system brain NS NS glioma NS NS NS y COSV51785554 COSM21688 174319529 c.353G>T p.R118L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 545 NS primary 66 ENSP00000492462.1:p.Arg118Leu ENST00000638463.1:c.353G>T 7:g.55155911G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MSU3-a 2809972 2666634 large_intestine colon transverse NS adenoma tubulovillous NS NS y COSV99292326 COSM9176305 174349512 c.961C>T p.R321W Substitution - Missense 38 7:55161579-55161579 + - NEUTRAL .28879 Confirmed somatic variant 26336987 surgery fresh/frozen primary 51 ENSP00000492462.1:p.Arg321Trp ENST00000638463.1:c.961C>T 7:g.55161579C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-AO-A12G-01 1899795 1788479 breast NS NS NS carcinoma NS NS NS y COSV51772564 COSM453241 174340672 c.199A>G p.T67A Substitution - Missense 38 7:55154080-55154080 + - PATHOGENIC .94785 Confirmed somatic variant 414 fresh/frozen - NOS primary 75 ENSP00000492462.1:p.Thr67Ala ENST00000638463.1:c.199A>G 7:g.55154080A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2014_Lung_sq_25_T 2744896 2603599 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 74 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MTP18_T1 2875797 2730359 pancreas NS NS NS other dysplasia-in_situ_neoplasm NS NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 32796935 surgery-fixed NS 74 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0001171-T01-IM3 2716747 2575568 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51850219 COSM6915112 174327753 c.1228G>T p.V410L Substitution - Missense het 38 7:55165403-55165403 + - PATHOGENIC .98789 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Val410Leu ENST00000638463.1:c.1228G>T 7:g.55165403G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0008258-T01-IM5 2724397 2583218 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-05-4382-01 1780053 1684052 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99288202 COSM7821254 174342572 c.1015G>C p.E339Q Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9875 Confirmed somatic variant 417 fresh/frozen - NOS primary 68 ENSP00000492462.1:p.Glu339Gln ENST00000638463.1:c.1015G>C 7:g.55163734G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-05-4382-01 1780053 1684052 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99288189 COSM7821080 174342551 c.47G>T p.R16L Substitution - Missense 38 7:55152582-55152582 + - PATHOGENIC .99698 Confirmed somatic variant 417 fresh/frozen - NOS primary 68 ENSP00000492462.1:p.Arg16Leu ENST00000638463.1:c.47G>T 7:g.55152582G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-DU-8162-01 2194248 2062526 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 61 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GBM_IV-39 2354294 2218452 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51778955 COSM4967262 174340792 c.62C>A p.S21Y Substitution - Missense 38 7:55152597-55152597 + - NEUTRAL .32595 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000492462.1:p.Ser21Tyr ENST00000638463.1:c.62C>A 7:g.55152597C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0002599-T01-IM3 2718855 2577676 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51832234 COSM6923248 174384042 c.914C>A p.S305Y Substitution - Missense het 38 7:55161532-55161532 + - PATHOGENIC .99176 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ser305Tyr ENST00000638463.1:c.914C>A 7:g.55161532C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-E1-A7YM-01 2457423 2320260 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 63 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-HT-A61C-01 2386268 2249100 central_nervous_system brain NS NS glioma NS NS NS y COSV51768130 COSM21684 174322412 c.169A>C p.T57P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 545 NS primary 66 ENSP00000492462.1:p.Thr57Pro ENST00000638463.1:c.169A>C 7:g.55154050A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0009327-T01-IM5 2725273 2584094 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0005127-T02-IM5 2721531 2580352 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51802355 COSM6941144 174320405 c.536C>T p.P179L Substitution - Missense het 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Pro179Leu ENST00000638463.1:c.536C>T 7:g.55156779C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 S00833_1 2480822 2343567 lung NS NS NS carcinoma small_cell_carcinoma NS NS y COSV51796349 COSM317275 174341900 c.1309A>G p.I437V Substitution - Missense 38 7:55172990-55172990 + - PATHOGENIC .91771 Confirmed somatic variant 26168399 surgery fresh/frozen primary 77 ENSP00000492462.1:p.Ile437Val ENST00000638463.1:c.1309A>G 7:g.55172990A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0010613-T01-IM5 2726312 2585133 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003128-T01-IM5 2719622 2578443 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 YUKAT 2439331 2302172 skin NS NS NS malignant_melanoma NS NS NS y COSV51838161 COSM5407720 174321088 c.376C>T p.P126S Substitution - Missense het 38 7:55155934-55155934 + - PATHOGENIC .91925 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 78 ENSP00000492462.1:p.Pro126Ser ENST00000638463.1:c.376C>T 7:g.55155934C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 Br001X 1312986 1223895 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51797037 COSM40998 174387625 c.1186G>C p.E396Q Substitution - Missense hom 38 7:55165361-55165361 + - PATHOGENIC .99549 Confirmed somatic variant 18772396 xenograft primary 4 ENSP00000492462.1:p.Glu396Gln ENST00000638463.1:c.1186G>C 7:g.55165361G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-ER-A19E-06 2121716 1995952 skin NS NS NS malignant_melanoma NS NS NS y COSV51817262 COSM3639733 174380066 c.337G>A p.E113K Substitution - Missense 38 7:55155895-55155895 + - PATHOGENIC .99356 Confirmed somatic variant 540 NS NS 36 ENSP00000492462.1:p.Glu113Lys ENST00000638463.1:c.337G>A 7:g.55155895G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TARGET-30-PAVDBS-01A-01D 2746863 2605566 autonomic_ganglia NS NS NS neuroblastoma NS NS NS y COSV51826171 COSM7252952 174336924 c.1306A>G p.K436E Substitution - Missense 38 7:55172987-55172987 + - PATHOGENIC .94412 Confirmed somatic variant 584 NS primary 3 ENSP00000492462.1:p.Lys436Glu ENST00000638463.1:c.1306A>G 7:g.55172987A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-VM-A8CD-01 2262980 2129964 central_nervous_system brain NS NS glioma NS NS NS y COSV99295978 COSM8269849 174355745 c.1129G>T p.A377S Substitution - Missense 38 7:55165304-55165304 + - PATHOGENIC .98882 Confirmed somatic variant 545 NS primary 58 ENSP00000492462.1:p.Ala377Ser ENST00000638463.1:c.1129G>T 7:g.55165304G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-VM-A8CD-01 2262980 2129964 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS primary 58 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51792433 COSM6966446 174352434 c.1144G>A p.G382S Substitution - Missense het 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Gly382Ser ENST00000638463.1:c.1144G>A 7:g.55165319G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 S001090 1027692 944668 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-CG-5721-01 2198017 2066295 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51782832 COSM3881808 174354668 c.121G>A p.D41N Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .98807 Confirmed somatic variant 541 NS NS 58 ENSP00000492462.1:p.Asp41Asn ENST00000638463.1:c.121G>A 7:g.55152656G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 Br230T 1313049 1223958 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 surgery - NOS primary 46 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 13T 2139248 2008776 upper_aerodigestive_tract mouth gingiva NS carcinoma squamous_cell_carcinoma NS NS y COSV51815394 COSM3715755 174328952 c.120C>A p.S40R Substitution - Missense 38 7:55152655-55152655 + - NEUTRAL .15461 Confirmed somatic variant 24292195 NS NS ENSP00000492462.1:p.Ser40Arg ENST00000638463.1:c.120C>A 7:g.55152655C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0009357-T01-IM5 2725300 2584121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 PD25645c 2843020 2698474 skin mucosal sinonasal NS malignant_melanoma NS NS NS y COSV104576411 COSM9505912 174396430 c.263A>T p.K88M Substitution - Missense 38 7:55154144-55154144 + - PATHOGENIC .88176 Confirmed somatic variant 30664638 surgery-fixed primary 58 ENSP00000492462.1:p.Lys88Met ENST00000638463.1:c.263A>T 7:g.55154144A>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-22-4609-01 2195227 2063505 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51827895 COSM3412174 174323173 c.67A>T p.S23C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 418 NS NS 81 ENSP00000492462.1:p.Ser23Cys ENST00000638463.1:c.67A>T 7:g.55152602A>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0011262-T01-IM5 2726872 2585693 endometrium NS NS NS carcinoma mixed_cell_carcinoma NS NS n COSV51803408 COSM6979939 174325822 c.1360G>A p.V454M Substitution - Missense het 38 7:55173041-55173041 + - PATHOGENIC .71586 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Val454Met ENST00000638463.1:c.1360G>A 7:g.55173041G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0004104-T01-IM5 2720505 2579326 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51846321 COSM6933335 174386013 c.1290T>G p.C430W Substitution - Missense het 38 7:55171202-55171202 + - .63273 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Cys430Trp ENST00000638463.1:c.1290T>G 7:g.55171202T>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1194727 1194727 1106622 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-FS-A1ZK-06 2121762 1995998 skin NS NS NS malignant_melanoma NS NS NS y COSV51790737 COSM3639739 174374628 c.1003C>T p.L335F Substitution - Missense 38 7:55161621-55161621 + - NEUTRAL .0484 Confirmed somatic variant 540 NS NS 68 ENSP00000492462.1:p.Leu335Phe ENST00000638463.1:c.1003C>T 7:g.55161621C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 WGC003566 2785058 2645174 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS y COSV51806564 COSM6920868 174327986 c.1388G>A p.R463Q Substitution - Missense 38 7:55173069-55173069 + - PATHOGENIC .99699 Confirmed somatic variant 25526346 surgery fresh/frozen primary 54 ENSP00000492462.1:p.Arg463Gln ENST00000638463.1:c.1388G>A 7:g.55173069G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-26-1439 2108054 1985915 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-GN-A8LN-01 2339478 2204461 skin NS NS NS malignant_melanoma NS NS NS y COSV99295991 COSM7976081 174351307 c.517G>A p.D173N Substitution - Missense 38 7:55156760-55156760 + - PATHOGENIC .99676 Confirmed somatic variant 540 NS primary 68 ENSP00000492462.1:p.Asp173Asn ENST00000638463.1:c.517G>A 7:g.55156760G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-GN-A8LN-01 2339478 2204461 skin NS NS NS malignant_melanoma NS NS NS y COSV99295987 COSM7976353 174351289 c.197C>T p.P66L Substitution - Missense 38 7:55154078-55154078 + - PATHOGENIC .98876 Confirmed somatic variant 540 NS primary 68 ENSP00000492462.1:p.Pro66Leu ENST00000638463.1:c.197C>T 7:g.55154078C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0747-01 1337860 1248245 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 53 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-CV-7250-01 2193784 2062062 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51827895 COSM3412174 174323173 c.67A>T p.S23C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 627 NS NS 64 ENSP00000492462.1:p.Ser23Cys ENST00000638463.1:c.67A>T 7:g.55152602A>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2011-2283:2012-316-T 2297701 2163302 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51817336 COSM4604310 174373715 c.758G>C p.G253A Substitution - Missense hom 38 7:55160216-55160216 + - PATHOGENIC .99469 Confirmed somatic variant 25056374 surgery-fixed NS ENSP00000492462.1:p.Gly253Ala ENST00000638463.1:c.758G>C 7:g.55160216G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-81-5910-01 2120398 1994634 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 174325029 c.136C>T p.R46C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 NS NS 64 ENSP00000492462.1:p.Arg46Cys ENST00000638463.1:c.136C>T 7:g.55154017C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-QB-AA9O-06 2339489 2204472 skin NS NS NS malignant_melanoma NS NS NS y COSV51785510 COSM6957413 174317862 c.484G>A p.D162N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 540 NS NS 73 ENSP00000492462.1:p.Asp162Asn ENST00000638463.1:c.484G>A 7:g.55156628G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0001582-T01-IM3 2717588 2576409 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769747 COSM297803 174351694 c.289G>C p.D97H Substitution - Missense het 38 7:55155847-55155847 + - PATHOGENIC .99461 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Asp97His ENST00000638463.1:c.289G>C 7:g.55155847G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 B42-S1 2732496 2591261 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV104576683 COSM9498592 174349101 c.340G>C p.E114Q Substitution - Missense 38 7:55155898-55155898 + - PATHOGENIC .98914 Confirmed somatic variant 29244145 surgery fresh/frozen primary 70.1 ENSP00000492462.1:p.Glu114Gln ENST00000638463.1:c.340G>C 7:g.55155898G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-CD-A4MI-01 2198040 2066318 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51771322 COSM3881814 174335407 c.433A>G p.I145V Substitution - Missense 38 7:55156577-55156577 + - PATHOGENIC .89527 Confirmed somatic variant 541 NS NS 62 ENSP00000492462.1:p.Ile145Val ENST00000638463.1:c.433A>G 7:g.55156577A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0007771-T01-IM5 2724004 2582825 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51862622 COSM6959670 174318255 c.704T>G p.V235G Substitution - Missense het 38 7:55160162-55160162 + - PATHOGENIC .9258 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Val235Gly ENST00000638463.1:c.704T>G 7:g.55160162T>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 ccRCC-90 1980826 1867072 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51815313 COSM1661639 174363332 c.55G>T p.G19C Substitution - Missense 38 7:55152590-55152590 + - PATHOGENIC .99717 Confirmed somatic variant 23797736 NS NS ENSP00000492462.1:p.Gly19Cys ENST00000638463.1:c.55G>T 7:g.55152590G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 CRC403 2730857 2589626 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105863818 COSM10064830 174333174 c.443C>T p.T148M Substitution - Missense 38 7:55156587-55156587 + - PATHOGENIC .97048 Confirmed somatic variant 26416732 xenograft metastasis ENSP00000492462.1:p.Thr148Met ENST00000638463.1:c.443C>T 7:g.55156587C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1194734 1194734 1106629 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-19-2621-01 2178211 2046509 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51863722 COSM13560 174338824 c.1253G>T p.C418F Substitution - Missense 38 7:55165428-55165428 + - PATHOGENIC .99905 Confirmed somatic variant 329 NS NS 83 ENSP00000492462.1:p.Cys418Phe ENST00000638463.1:c.1253G>T 7:g.55165428G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-12-0657-01 2178279 2046577 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772147 COSM375343 174337812 c.1316C>G p.S439C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Confirmed somatic variant 329 NS NS 69 ENSP00000492462.1:p.Ser439Cys ENST00000638463.1:c.1316C>G 7:g.55172997C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-DU-6410-01 2194391 2062669 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 56 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 W016-S1 2732510 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51785510 COSM6957413 174317862 c.484G>A p.D162N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000492462.1:p.Asp162Asn ENST00000638463.1:c.484G>A 7:g.55156628G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 W016-S1 2732510 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0002124-T01-IM3 2829436 2685251 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51806564 COSM6920868 174327986 c.1388G>A p.R463Q Substitution - Missense 38 7:55173069-55173069 + - PATHOGENIC .99699 Confirmed somatic variant 30205045 surgery-fixed metastasis 53 ENSP00000492462.1:p.Arg463Gln ENST00000638463.1:c.1388G>A 7:g.55173069G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 YUFARCI 2013606 1896238 skin NS NS NS malignant_melanoma NS NS NS y COSV51816429 COSM1698693 174334855 c.1192A>G p.N398D Substitution - Missense het 38 7:55165367-55165367 + - NEUTRAL .4812 Confirmed somatic variant 22842228 NS NS ENSP00000492462.1:p.Asn398Asp ENST00000638463.1:c.1192A>G 7:g.55165367A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0006363-T01-IM5 2722740 2581561 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 174320891 c.248C>A p.A83D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000492462.1:p.Ala83Asp ENST00000638463.1:c.248C>A 7:g.55154129C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0006363-T01-IM5 2722740 2581561 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0002022-T01-IM3 2718329 2577150 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 174325029 c.136C>T p.R46C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Arg46Cys ENST00000638463.1:c.136C>T 7:g.55154017C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2696712 2696712 2555616 oesophagus NS NS NS other metaplasia epidermoid NS n COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28731047 surgery-fixed primary 65 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 PT36 2521293 2383636 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV51784241 COSM5915646 174358823 c.572C>T p.T191I Substitution - Missense 38 7:55156815-55156815 + - PATHOGENIC .99038 Confirmed somatic variant 25759019 surgery fresh/frozen NS ENSP00000492462.1:p.Thr191Ile ENST00000638463.1:c.572C>T 7:g.55156815C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-12-0691-01 2178100 2046398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774829 COSM1451549 174320530 c.149A>G p.D50G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 329 NS NS 63 ENSP00000492462.1:p.Asp50Gly ENST00000638463.1:c.149A>G 7:g.55154030A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0006368-T01-IM5 2722745 2581566 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51843325 COSM6950386 174355486 c.484G>T p.D162Y Substitution - Missense het 38 7:55156628-55156628 + - PATHOGENIC .97349 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000492462.1:p.Asp162Tyr ENST00000638463.1:c.484G>T 7:g.55156628G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-BB-8596-01 2193542 2061820 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99289667 COSM8311578 174360039 c.889G>A p.G297S Substitution - Missense 38 7:55161507-55161507 + - NEUTRAL .07845 Confirmed somatic variant 627 NS NS 69 ENSP00000492462.1:p.Gly297Ser ENST00000638463.1:c.889G>A 7:g.55161507G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0155 2107953 1985814 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 174321914 c.292C>T p.H98Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.His98Tyr ENST00000638463.1:c.292C>T 7:g.55155850C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0002105-T01-IM3 2718403 2577224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51844520 COSM6920741 174346223 c.21C>G p.I7M Substitution - Missense het 38 7:55152556-55152556 + - PATHOGENIC .89498 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Ile7Met ENST00000638463.1:c.21C>G 7:g.55152556C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0000378-T01-IM3 2715158 2573979 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849115 COSM6910123 174341390 c.97G>T p.G33C Substitution - Missense het 38 7:55152632-55152632 + - PATHOGENIC .99578 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Gly33Cys ENST00000638463.1:c.97G>T 7:g.55152632G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0000378-T01-IM3 2715158 2573979 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 174337713 c.1175G>C p.G392A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Gly392Ala ENST00000638463.1:c.1175G>C 7:g.55165350G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2014_Lung_sq_14_T 2744885 2603588 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 58 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0006758-T01-IM5 2723137 2581958 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51797815 COSM6953729 174354466 c.1249A>C p.N417H Substitution - Missense het 38 7:55165424-55165424 + - PATHOGENIC .99714 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Asn417His ENST00000638463.1:c.1249A>C 7:g.55165424A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 C086 2465276 2328109 NS NS NS NS malignant_melanoma NS NS NS y COSV51845994 COSM5530405 174318236 c.1015G>A p.E339K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 23890154 cell-line metastasis ENSP00000492462.1:p.Glu339Lys ENST00000638463.1:c.1015G>A 7:g.55163734G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 S001103 1027689 944665 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 174322412 c.169A>C p.T57P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000492462.1:p.Thr57Pro ENST00000638463.1:c.169A>C 7:g.55154050A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 J11 2815385 2671765 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 29263181 surgery fresh/frozen NS 50 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 EXTERN_MELA_20140530_022 2839470 2695236 skin lip NS NS malignant_melanoma NS NS NS y COSV104577007 COSM9448763 174348730 c.1316C>T p.S439F Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99547 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000492462.1:p.Ser439Phe ENST00000638463.1:c.1316C>T 7:g.55172997C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 DCG_04 2664382 2524436 central_nervous_system cerebellum NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51838314 COSM6837033 174326957 c.868G>A p.E290K Substitution - Missense 38 7:55160326-55160326 + - NEUTRAL .08736 Confirmed somatic variant 28852847 surgery fresh/frozen NS 40 ENSP00000492462.1:p.Glu290Lys ENST00000638463.1:c.868G>A 7:g.55160326G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-32-1979-01 2120345 1994581 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 174323026 c.191A>G p.Y64C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 329 NS NS 69 ENSP00000492462.1:p.Tyr64Cys ENST00000638463.1:c.191A>G 7:g.55154072A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0008179-T01-IM5 2830114 2685929 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 174325395 c.1156G>A p.V386I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000492462.1:p.Val386Ile ENST00000638463.1:c.1156G>A 7:g.55165331G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-12-0619-01 1909590 1798111 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 fresh/frozen - NOS primary 60 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 B105-0 2097254 1975318 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV51776529 COSM1755314 174369526 c.1262G>A p.G421E Substitution - Missense 38 7:55165437-55165437 + - PATHOGENIC .99581 Confirmed somatic variant 24121792 fresh/frozen - NOS NS ENSP00000492462.1:p.Gly421Glu ENST00000638463.1:c.1262G>A 7:g.55165437G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MB-T29 2802988 2659798 breast NS NS NS carcinoma ER-PR-positive_carcinoma NS NS n COSV51836185 COSM4884832 174350588 c.121G>T p.D41Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 26960396 fixed - NOS NS 83 ENSP00000492462.1:p.Asp41Tyr ENST00000638463.1:c.121G>T 7:g.55152656G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-14-1456-01 1338007 1248392 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 23 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0008777-T01-IM5 2724826 2583647 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-92-6393-Tumor-SM-7CKB6 2640208 2500509 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma NS NS y COSV51802220 COSM6458155 174319564 c.322G>A p.D108N Substitution - Missense 38 7:55155880-55155880 + - PATHOGENIC .94623 Confirmed somatic variant 28098136 surgery-fixed primary 65 ENSP00000492462.1:p.Asp108Asn ENST00000638463.1:c.322G>A 7:g.55155880G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-27-1838-01 1338063 1248448 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 174320891 c.248C>A p.A83D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000492462.1:p.Ala83Asp ENST00000638463.1:c.248C>A 7:g.55154129C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-1804-01 2120260 1994496 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51855357 COSM3412180 174363462 c.148G>T p.D50Y Substitution - Missense 38 7:55154029-55154029 + - PATHOGENIC .9742 Confirmed somatic variant 329 NS NS 81 ENSP00000492462.1:p.Asp50Tyr ENST00000638463.1:c.148G>T 7:g.55154029G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-14-0790-01 1337989 1248374 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 64 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-VQ-A8PX-01 2339506 2204489 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99285314 COSM8202780 174349953 c.53G>A p.R18H Substitution - Missense 38 7:55152588-55152588 + - PATHOGENIC .91275 Confirmed somatic variant 541 NS primary 51 ENSP00000492462.1:p.Arg18His ENST00000638463.1:c.53G>A 7:g.55152588G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0001124-T01-IM3 2716673 2575494 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51781531 COSM6914964 174340830 c.32A>T p.Q11L Substitution - Missense het 38 7:55152567-55152567 + - PATHOGENIC .9889 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Gln11Leu ENST00000638463.1:c.32A>T 7:g.55152567A>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0007562-T01-IM5 2723848 2582669 soft_tissue fibrous_tissue_and_uncertain_origin NS NS malignant_fibrous_histiocytoma-pleomorphic_sarcoma NS NS NS n COSV51779875 COSM6958517 174376664 c.304G>A p.V102I Substitution - Missense het 38 7:55155862-55155862 + - PATHOGENIC .99324 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Val102Ile ENST00000638463.1:c.304G>A 7:g.55155862G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 PD9568a 1649032 1563971 breast NS NS NS carcinoma ductal_carcinoma NS NS y COSV51788518 COSM5752712 174345728 c.1168C>G p.P390A Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99615 Confirmed somatic variant 27135926 NS NS ENSP00000492462.1:p.Pro390Ala ENST00000638463.1:c.1168C>G 7:g.55165343C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0008179-T01-IM5 2787021 2644444 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51799199 COSM1251020 174325395 c.1156G>A p.V386I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000492462.1:p.Val386Ile ENST00000638463.1:c.1156G>A 7:g.55165331G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV99293869 COSM8151148 174356285 c.490C>A p.H164N Substitution - Missense 38 7:55156634-55156634 + - NEUTRAL .19929 Confirmed somatic variant 540 NS NS 37 ENSP00000492462.1:p.His164Asn ENST00000638463.1:c.490C>A 7:g.55156634C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0005929-T01-IM5 2722311 2581132 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 5-WS012-T14 2869947 2724944 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110458 COSM9657212 174376423 c.833_834delinsTT p.S278F Substitution - Missense 38 7:55160291-55160292 + - Confirmed somatic variant 26950094 surgery - NOS NS 82 ENSP00000492462.1:p.Ser278Phe ENST00000638463.1:c.833_834delinsTT 7:g.55160291_55160292delinsTT EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P122 2072582 1951937 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 55.2 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-12-0656 2108024 1985885 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 174320891 c.248C>A p.A83D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Ala83Asp ENST00000638463.1:c.248C>A 7:g.55154129C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-FP-A4BE-01 2197995 2066273 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51785413 COSM1176673 174327537 c.137G>A p.R46H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 541 NS NS 55 ENSP00000492462.1:p.Arg46His ENST00000638463.1:c.137G>A 7:g.55154018G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-D1-A103-01 1783494 1687493 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99294091 COSM9081690 174334757 c.1370G>T p.G457V Substitution - Missense 38 7:55173051-55173051 + - PATHOGENIC .792 Confirmed somatic variant 419 fresh/frozen - NOS primary 87 ENSP00000492462.1:p.Gly457Val ENST00000638463.1:c.1370G>T 7:g.55173051G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-76-6661-01 2120394 1994630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51814881 COSM3929116 174342011 c.316G>T p.G106W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 329 NS NS 54 ENSP00000492462.1:p.Gly106Trp ENST00000638463.1:c.316G>T 7:g.55155874G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-76-6661-01 2120394 1994630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 174321914 c.292C>T p.H98Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 NS NS 54 ENSP00000492462.1:p.His98Tyr ENST00000638463.1:c.292C>T 7:g.55155850C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 Br247T 1313059 1223968 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827490 COSM39163 174340256 c.1289G>A p.C430Y Substitution - Missense het 38 7:55171201-55171201 + - PATHOGENIC .98251 Confirmed somatic variant 18772396 surgery - NOS primary 39 ENSP00000492462.1:p.Cys430Tyr ENST00000638463.1:c.1289G>A 7:g.55171201G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 IGC-04-1136 2662303 2522427 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51809481 COSM6530127 174335854 c.373G>C p.G125R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .97571 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000492462.1:p.Gly125Arg ENST00000638463.1:c.373G>C 7:g.55155931G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-CH-5765-01 1797170 1698917 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51795500 COSM1131544 174360965 c.74G>C p.C25S Substitution - Missense 38 7:55152609-55152609 + - PATHOGENIC .99547 Confirmed somatic variant 435 fresh/frozen - NOS primary 55 ENSP00000492462.1:p.Cys25Ser ENST00000638463.1:c.74G>C 7:g.55152609G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0000894-T01-IM3 2716206 2575027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51822498 COSM3266565 174354571 c.299C>T p.S100L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Ser100Leu ENST00000638463.1:c.299C>T 7:g.55155857C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-12-0691 2108027 1985888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774829 COSM1451549 174320530 c.149A>G p.D50G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Asp50Gly ENST00000638463.1:c.149A>G 7:g.55154030A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-ER-A42L-06 2456271 2319108 skin NS NS NS malignant_melanoma NS NS NS y COSV99287971 COSM7900658 174350818 c.1163C>T p.T388I Substitution - Missense 38 7:55165338-55165338 + - PATHOGENIC .94394 Confirmed somatic variant 540 NS metastasis 49 ENSP00000492462.1:p.Thr388Ile ENST00000638463.1:c.1163C>T 7:g.55165338C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0006622-T01-IM5 2786996 2644419 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51845994 COSM5530405 174318236 c.1015G>A p.E339K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000492462.1:p.Glu339Lys ENST00000638463.1:c.1015G>A 7:g.55163734G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1194733 1194733 1106628 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 SDC7 2564876 2426270 salivary_gland NS NS NS carcinoma salivary_duct_carcinoma NS NS y COSV51792147 COSM5988249 174347335 c.552G>T p.Q184H Substitution - Missense 38 7:55156795-55156795 + - NEUTRAL .3446 Confirmed somatic variant 27103403 surgery fresh/frozen recurrent ENSP00000492462.1:p.Gln184His ENST00000638463.1:c.552G>T 7:g.55156795G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 Br20P 1312980 1223889 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51815967 COSM39522 174320843 c.37T>G p.C13G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 18772396 surgery - NOS primary 77 ENSP00000492462.1:p.Cys13Gly ENST00000638463.1:c.37T>G 7:g.55152572T>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0009587-T01-IM5 2725481 2584302 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0009587-T01-IM5 2725481 2584302 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 ESCC_BICR_010T 2456865 2319702 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51822386 COSM5436048 174373481 c.956C>G p.S319C Substitution - Missense 38 7:55161574-55161574 + - PATHOGENIC .96861 Confirmed somatic variant 582 NS primary 70 ENSP00000492462.1:p.Ser319Cys ENST00000638463.1:c.956C>G 7:g.55161574C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 EX01M 2653306 2513433 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS metastasis 58.5 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 CRC104post 2730749 2589518 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV104577027 COSM9413135 174337528 c.776G>A p.G259E Substitution - Missense 38 7:55160234-55160234 + - NEUTRAL .11765 Confirmed somatic variant 26416732 xenograft metastasis 62 ENSP00000492462.1:p.Gly259Glu ENST00000638463.1:c.776G>A 7:g.55160234G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0743-01 1337857 1248242 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 69 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0002647-T01-IM3 2718893 2577714 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0881-01 1337868 1248253 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-14-1395-01 2120295 1994531 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51827895 COSM3412174 174323173 c.67A>T p.S23C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 329 NS NS 52 ENSP00000492462.1:p.Ser23Cys ENST00000638463.1:c.67A>T 7:g.55152602A>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 16965 1423769 1333797 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51774819 COSM35840 174322963 c.1333G>A p.V445M Substitution - Missense het 38 7:55173014-55173014 + - PATHOGENIC .99458 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000492462.1:p.Val445Met ENST00000638463.1:c.1333G>A 7:g.55173014G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2876622 2876622 2731137 lung NS NS NS carcinoma NS NS NS n COSV51785510 COSM6957413 174317862 c.484G>A p.D162N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 29506987 circulating tumour NS 51 ENSP00000492462.1:p.Asp162Asn ENST00000638463.1:c.484G>A 7:g.55156628G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 T2935 2658562 2518721 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51820069 COSM6652271 174328352 c.1313C>T p.P438L Substitution - Missense 38 7:55172994-55172994 + - PATHOGENIC .98245 Confirmed somatic variant 27149842 NS NS 64.16 ENSP00000492462.1:p.Pro438Leu ENST00000638463.1:c.1313C>T 7:g.55172994C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 T3022 2658418 2518577 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51770269 COSM5710629 174354619 c.397G>A p.G133R Substitution - Missense 38 7:55156541-55156541 + - PATHOGENIC .9949 Confirmed somatic variant 27149842 NS NS 74.83 ENSP00000492462.1:p.Gly133Arg ENST00000638463.1:c.397G>A 7:g.55156541G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-19-1388-01 2178164 2046462 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289486 COSM7485141 174375287 c.1206G>C p.W402C Substitution - Missense 38 7:55165381-55165381 + - PATHOGENIC .98435 Confirmed somatic variant 329 NS NS 58 ENSP00000492462.1:p.Trp402Cys ENST00000638463.1:c.1206G>C 7:g.55165381G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0002294-T02-IM5 2719498 2578319 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51817765 COSM6959438 174328664 c.1184G>A p.G395E Substitution - Missense het 38 7:55165359-55165359 + - PATHOGENIC .9907 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Gly395Glu ENST00000638463.1:c.1184G>A 7:g.55165359G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 S00833 1759198 1663946 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51796349 COSM317275 174341900 c.1309A>G p.I437V Substitution - Missense 38 7:55172990-55172990 + - PATHOGENIC .91771 Confirmed somatic variant 22941188 fresh/frozen - NOS NS 77 ENSP00000492462.1:p.Ile437Val ENST00000638463.1:c.1309A>G 7:g.55172990A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0009830-T01-IM5 2725668 2584489 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 174327537 c.137G>A p.R46H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Arg46His ENST00000638463.1:c.137G>A 7:g.55154018G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0006622-T01-IM5 2723002 2581823 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51845994 COSM5530405 174318236 c.1015G>A p.E339K Substitution - Missense het 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Glu339Lys ENST00000638463.1:c.1015G>A 7:g.55163734G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 Pat_41_B 2513797 2376166 NS NS NS NS malignant_melanoma NS NS NS y COSV51772860 COSM5872872 174356472 c.65C>T p.P22L Substitution - Missense 38 7:55152600-55152600 + - PATHOGENIC .99115 Confirmed somatic variant 24265153 surgery-fixed NS 76 ENSP00000492462.1:p.Pro22Leu ENST00000638463.1:c.65C>T 7:g.55152600C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-76-6656-01 2120392 1994628 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51857475 COSM3412176 174363364 c.101G>A p.C34Y Substitution - Missense 38 7:55152636-55152636 + - PATHOGENIC .99504 Confirmed somatic variant 329 NS NS 66 ENSP00000492462.1:p.Cys34Tyr ENST00000638463.1:c.101G>A 7:g.55152636G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003702-T02-IM5 2720190 2579011 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51831642 COSM1496684 174333100 c.370G>A p.E124K Substitution - Missense het 38 7:55155928-55155928 + - PATHOGENIC .94538 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Glu124Lys ENST00000638463.1:c.370G>A 7:g.55155928G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV104368998 COSM9232920 174336611 c.268C>T p.P90S Substitution - Missense het 38 7:55154149-55154149 + - PATHOGENIC .98876 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000492462.1:p.Pro90Ser ENST00000638463.1:c.268C>T 7:g.55154149C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0001703-T01-IM3 2717826 2576647 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51782832 COSM3881808 174354668 c.121G>A p.D41N Substitution - Missense het 38 7:55152656-55152656 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Asp41Asn ENST00000638463.1:c.121G>A 7:g.55152656G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 T2250 2658595 2518754 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51769145 COSM3266559 174356454 c.256G>A p.V86M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 27149842 NS NS 62.08 ENSP00000492462.1:p.Val86Met ENST00000638463.1:c.256G>A 7:g.55154137G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-14-1456 2108037 1985898 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-5856-01 2120270 1994506 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 58 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-14-1823-01 1338013 1248398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 58 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0125 2107938 1985799 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T TTN_ENST00000591111 ENST00000591111.5 103053 12403 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV59957361 COSM130006 165925743 c.184C>T p.R62C Substitution - Missense 38 2:178802249-178802249 - - PATHOGENIC .99021 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000465570.1:p.Arg62Cys ENST00000591111.5:c.184C>T 2:g.178802249G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-DF-A2KN-01 2457388 2320225 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99289848 COSM9047248 174334495 c.440C>T p.A147V Substitution - Missense 38 7:55156584-55156584 + - PATHOGENIC .99015 Confirmed somatic variant 419 NS primary ENSP00000492462.1:p.Ala147Val ENST00000638463.1:c.440C>T 7:g.55156584C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P146 2072599 1951954 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 48 ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-FG-A70Z-01 2194226 2062504 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 53 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0002490-T01-IM3 2718762 2577583 NS NS NS NS malignant_melanoma NS NS NS n COSV51822525 COSM6922832 174358283 c.722C>T p.S241F Substitution - Missense het 38 7:55160180-55160180 + - .61329 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Ser241Phe ENST00000638463.1:c.722C>T 7:g.55160180C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0002490-T01-IM3 2718762 2577583 NS NS NS NS malignant_melanoma NS NS NS n COSV51822498 COSM3266565 174354571 c.299C>T p.S100L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Ser100Leu ENST00000638463.1:c.299C>T 7:g.55155857C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0011389-T01-IM5 2726985 2585806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GBM19-I3 2813467 2669859 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-FG-A4MW-01 2194412 2062690 central_nervous_system brain NS NS glioma NS NS NS y COSV51814881 COSM3929116 174342011 c.316G>T p.G106W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 545 NS NS 63 ENSP00000492462.1:p.Gly106Trp ENST00000638463.1:c.316G>T 7:g.55155874G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MBC_61 2662766 2522890 breast NS NS NS carcinoma ER-PR-positive_carcinoma NS NS y COSV51771306 COSM1318972 174335686 c.1295C>T p.T432M Substitution - Missense 38 7:55171207-55171207 + - NEUTRAL .03249 Confirmed somatic variant 28027327 fresh/frozen - NOS NS ENSP00000492462.1:p.Thr432Met ENST00000638463.1:c.1295C>T 7:g.55171207C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-02-2466-01 2178184 2046482 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 61 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-BA-4075-01 2193631 2061909 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99292704 COSM8332917 174347160 c.1019C>A p.P340Q Substitution - Missense 38 7:55163738-55163738 + - PATHOGENIC .97378 Confirmed somatic variant 627 NS NS 49 ENSP00000492462.1:p.Pro340Gln ENST00000638463.1:c.1019C>A 7:g.55163738C>A SLC13A2_ENST00000314669 ENST00000314669.9 1779 10917 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105903232 COSM10012975 103184066 c.441G>A p.M147I Substitution - Missense 38 17:28490773-28490773 + - PATHOGENIC .96983 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000316202.5:p.Met147Ile ENST00000314669.9:c.441G>A 17:g.28490773G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 SA213 1659983 1574311 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS y COSV51858303 COSM214296 174369953 c.541C>G p.L181V Substitution - Missense 38 7:55156784-55156784 + - PATHOGENIC .93843 Confirmed somatic variant 22495314 fresh/frozen - NOS primary 49 ENSP00000492462.1:p.Leu181Val ENST00000638463.1:c.541C>G 7:g.55156784C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0185 2107964 1985825 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774819 COSM35840 174322963 c.1333G>A p.V445M Substitution - Missense 38 7:55173014-55173014 + - PATHOGENIC .99458 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Val445Met ENST00000638463.1:c.1333G>A 7:g.55173014G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-28-5207 2108065 1985926 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-EY-A2OM-01 2198301 2066579 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99285698 COSM9064376 174333658 c.215A>G p.D72G Substitution - Missense 38 7:55154096-55154096 + - PATHOGENIC .95224 Confirmed somatic variant 419 NS NS 55 ENSP00000492462.1:p.Asp72Gly ENST00000638463.1:c.215A>G 7:g.55154096A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 EXTERN_MELA_20140505_038 2839416 2695182 skin ear NS NS malignant_melanoma NS NS NS y COSV104577055 COSM9446911 174345074 c.269C>T p.P90L Substitution - Missense 38 7:55154150-55154150 + - PATHOGENIC .98876 Confirmed somatic variant 28467829 surgery fresh/frozen recurrent ENSP00000492462.1:p.Pro90Leu ENST00000638463.1:c.269C>T 7:g.55154150C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-WE-AAA4-06 2339475 2204458 skin NS NS NS malignant_melanoma NS NS NS y COSV99286479 COSM8046349 174337859 c.772T>C p.S258P Substitution - Missense 38 7:55160230-55160230 + - PATHOGENIC .73545 Confirmed somatic variant 540 NS NS 56 ENSP00000492462.1:p.Ser258Pro ENST00000638463.1:c.772T>C 7:g.55160230T>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0011540-T01-IM5 2727112 2585933 small_intestine ileum NS NS carcinoma adenocarcinoma NS NS n COSV51797215 COSM145360 174331056 c.349G>A p.V117I Substitution - Missense het 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Val117Ile ENST00000638463.1:c.349G>A 7:g.55155907G>A FRY ENST00000542859.5 9042 20367 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105932591 COSM10012802 156047604 c.1969G>A p.D657N Substitution - Missense 38 13:32171088-32171088 + - PATHOGENIC .96279 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000445043.2:p.Asp657Asn ENST00000542859.5:c.1969G>A 13:g.32171088G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0010340-T01-IM5 2726107 2584928 NS NS NS NS malignant_melanoma NS NS NS n COSV51799199 COSM1251020 174325395 c.1156G>A p.V386I Substitution - Missense het 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Val386Ile ENST00000638463.1:c.1156G>A 7:g.55165331G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 EXTERN_MELA_20140924_067 2839387 2695153 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV104577161 COSM9392986 174368328 c.826G>A p.G276R Substitution - Missense 38 7:55160284-55160284 + - PATHOGENIC .93959 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000492462.1:p.Gly276Arg ENST00000638463.1:c.826G>A 7:g.55160284G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0009873-T01-IM5 2725712 2584533 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0004379-T01-IM5 2720790 2579611 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51857819 COSM6935325 174336523 c.779A>C p.N260T Substitution - Missense het 38 7:55160237-55160237 + - PATHOGENIC .99346 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Asn260Thr ENST00000638463.1:c.779A>C 7:g.55160237A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0008215-T01-IM5 2830122 2685937 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51834499 COSM6845063 174319637 c.346G>A p.G116S Substitution - Missense 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 30205045 surgery-fixed primary 58 ENSP00000492462.1:p.Gly116Ser ENST00000638463.1:c.346G>A 7:g.55155904G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 618 1630888 1547758 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51797215 COSM145360 174331056 c.349G>A p.V117I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 22158541 blood-bone marrow NS ENSP00000492462.1:p.Val117Ile ENST00000638463.1:c.349G>A 7:g.55155907G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 OSCC-GB_00130111 2121052 1995288 upper_aerodigestive_tract mouth NS NS carcinoma NS NS NS y COSV51815394 COSM3715755 174328952 c.120C>A p.S40R Substitution - Missense 38 7:55152655-55152655 + - NEUTRAL .15461 Confirmed somatic variant 539 NS NS ENSP00000492462.1:p.Ser40Arg ENST00000638463.1:c.120C>A 7:g.55152655C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 OSCC-GB_00550111 2340760 2205743 upper_aerodigestive_tract mouth NS NS carcinoma NS NS NS y COSV51836185 COSM4884832 174350588 c.121G>T p.D41Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 539 NS primary 58 ENSP00000492462.1:p.Asp41Tyr ENST00000638463.1:c.121G>T 7:g.55152656G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 Br02X 1312964 1223873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense hom 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 xenograft primary 39 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 PD7043a 1504254 1427132 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia NS n COSV51852469 COSM4384119 174324091 c.799A>G p.N267D Substitution - Missense 38 7:55160257-55160257 + - NEUTRAL .3314 Confirmed somatic variant 24030381 NS NS ENSP00000492462.1:p.Asn267Asp ENST00000638463.1:c.799A>G 7:g.55160257A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-14-0789-01 1337988 1248373 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51851464 COSM3412200 174363168 c.1265G>A p.C422Y Substitution - Missense 38 7:55171177-55171177 + - PATHOGENIC .98191 Confirmed somatic variant 329 surgery fresh/frozen NS 54 ENSP00000492462.1:p.Cys422Tyr ENST00000638463.1:c.1265G>A 7:g.55171177G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 SJALL040461-D 2824035 2679863 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV104576718 COSM9280424 174333366 c.974G>A p.R325Q Substitution - Missense 38 7:55161592-55161592 + - PATHOGENIC .99386 Confirmed somatic variant 31697823 blood-bone marrow NS 11.64 ENSP00000492462.1:p.Arg325Gln ENST00000638463.1:c.974G>A 7:g.55161592G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-02-2485-01 1337809 1248194 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 174320891 c.248C>A p.A83D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 NS NS 53 ENSP00000492462.1:p.Ala83Asp ENST00000638463.1:c.248C>A 7:g.55154129C>A CDH9 ENST00000231021.8 2370 1768 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV50278301 COSM3014089 101810994 c.1759C>T p.R587C Substitution - Missense 38 5:26885737-26885737 - - PATHOGENIC .98755 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000231021.4:p.Arg587Cys ENST00000231021.8:c.1759C>T 5:g.26885737G>A TTN_ENST00000591111 ENST00000591111.5 103053 12403 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105912072 COSM10012820 165841129 c.9543A>T p.K3181N Substitution - Missense 38 2:178766541-178766541 - - PATHOGENIC .90433 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000465570.1:p.Lys3181Asn ENST00000591111.5:c.9543A>T 2:g.178766541T>A ACACB ENST00000338432.11 7377 85 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105910389 COSM10012924 103168919 c.863G>A p.R288H Substitution - Missense 38 12:109167972-109167972 + - PATHOGENIC .98749 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000341044.7:p.Arg288His ENST00000338432.11:c.863G>A 12:g.109167972G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-81-5911-01 2120399 1994635 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 33 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GYWU_828 2771354 2629545 adrenal_gland adrenal_gland NS NS adrenal_cortical_carcinoma NS NS NS n COSV51794659 COSM6652247 174343687 c.1102C>T p.R368W Substitution - Missense 38 7:55163821-55163821 + - PATHOGENIC .97962 Confirmed somatic variant 30113656 surgery-fixed NS ENSP00000492462.1:p.Arg368Trp ENST00000638463.1:c.1102C>T 7:g.55163821C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 LICA-CN-HCC121T 2634168 2494564 liver NS NS NS other neoplasm NS NS y COSV51825459 COSM122789 174330852 c.805A>G p.I269V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Confirmed somatic variant 660 NS primary 49 ENSP00000492462.1:p.Ile269Val ENST00000638463.1:c.805A>G 7:g.55160263A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0002998-T01-IM3 2719207 2578028 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51805664 COSM6925533 174372069 c.1165T>G p.C389G Substitution - Missense het 38 7:55165340-55165340 + - PATHOGENIC .9957 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Cys389Gly ENST00000638463.1:c.1165T>G 7:g.55165340T>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801711 COSM3923810 174370087 c.289G>A p.D97N Substitution - Missense 38 7:55155847-55155847 + - PATHOGENIC .99324 Confirmed somatic variant 540 NS NS 68 ENSP00000492462.1:p.Asp97Asn ENST00000638463.1:c.289G>A 7:g.55155847G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-28-1749-01 2178174 2046472 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 174333195 c.470C>T p.T157I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 NS NS 73 ENSP00000492462.1:p.Thr157Ile ENST00000638463.1:c.470C>T 7:g.55156614C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2665864 2665864 2525572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792237 COSM6842523 174330879 c.211_212delinsGA p.M71E Substitution - Missense het 38 7:55154092-55154093 + - Confirmed somatic variant 28979142 surgery - NOS NS 70 ENSP00000492462.1:p.Met71Glu ENST00000638463.1:c.211_212delinsGA 7:g.55154092_55154093delinsGA EGFR_ENST00000638463 ENST00000638463.1 1392 3236 Br229T 1313048 1223957 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51848573 COSM39565 174353720 c.313T>A p.C105S Substitution - Missense het 38 7:55155871-55155871 + - PATHOGENIC .98855 Confirmed somatic variant 18772396 surgery - NOS primary 28 ENSP00000492462.1:p.Cys105Ser ENST00000638463.1:c.313T>A 7:g.55155871T>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 pfg413T 2309709 2174911 stomach NS NS NS carcinoma intestinal_adenocarcinoma NS NS y COSV51771306 COSM1318972 174335686 c.1295C>T p.T432M Substitution - Missense het 38 7:55171207-55171207 + - NEUTRAL .03249 Confirmed somatic variant 24816253 surgery fresh/frozen NS 65 ENSP00000492462.1:p.Thr432Met ENST00000638463.1:c.1295C>T 7:g.55171207C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-DI-A1BU-01 2198300 2066578 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99287849 COSM8863291 174345873 c.1048A>G p.I350V Substitution - Missense 38 7:55163767-55163767 + - NEUTRAL .09266 Confirmed somatic variant 419 NS NS 55 ENSP00000492462.1:p.Ile350Val ENST00000638463.1:c.1048A>G 7:g.55163767A>G FSCB ENST00000340446.4 2478 20494 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105904335 COSM10012935 106113770 c.1267G>A p.D423N Substitution - Missense 38 14:44505721-44505721 - - NEUTRAL .15871 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000344579.4:p.Asp423Asn ENST00000340446.4:c.1267G>A 14:g.44505721C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-KK-A59Y-01 2340238 2205221 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51814881 COSM3929116 174342011 c.316G>T p.G106W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 435 NS primary 56 ENSP00000492462.1:p.Gly106Trp ENST00000638463.1:c.316G>T 7:g.55155874G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 R056-I1 2813481 2669873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289246 COSM8268187 174322063 c.170C>T p.T57I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 28263318 surgery fresh/frozen NS 42 ENSP00000492462.1:p.Thr57Ile ENST00000638463.1:c.170C>T 7:g.55154051C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2842026 2842026 2697575 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 174332720 c.856A>C p.S286R Substitution - Missense 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000492462.1:p.Ser286Arg ENST00000638463.1:c.856A>C 7:g.55160314A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-BR-6452-01 2197940 2066218 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51804028 COSM3881820 174331866 c.889G>T p.G297C Substitution - Missense 38 7:55161507-55161507 + - NEUTRAL .38516 Confirmed somatic variant 541 NS NS 78 ENSP00000492462.1:p.Gly297Cys ENST00000638463.1:c.889G>T 7:g.55161507G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-E5-A2PC-01 1898110 1786794 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51779680 COSM1313184 174348858 c.533C>G p.T178S Substitution - Missense 38 7:55156776-55156776 + - PATHOGENIC .98418 Confirmed somatic variant 413 fresh/frozen - NOS primary 61 ENSP00000492462.1:p.Thr178Ser ENST00000638463.1:c.533C>G 7:g.55156776C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 5-VS083-T1 2869916 2724913 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51776967 COSM6963220 174335149 c.1312C>T p.P438S Substitution - Missense 38 7:55172993-55172993 + - PATHOGENIC .96242 Confirmed somatic variant 26950094 surgery - NOS NS 72 ENSP00000492462.1:p.Pro438Ser ENST00000638463.1:c.1312C>T 7:g.55172993C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-28-5213-01 2120336 1994572 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 72 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787557 COSM6191456 174320363 c.719C>T p.T240I Substitution - Missense 38 7:55160177-55160177 + - NEUTRAL .13103 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000492462.1:p.Thr240Ile ENST00000638463.1:c.719C>T 7:g.55160177C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0007319-T01-IM5 2723658 2582479 penis NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51785510 COSM6957413 174317862 c.484G>A p.D162N Substitution - Missense het 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Asp162Asn ENST00000638463.1:c.484G>A 7:g.55156628G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 10677523 2751151 2609847 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV105822269 COSM9522392 174341608 c.388G>C p.V130L Substitution - Missense 38 7:55155946-55155946 + - Confirmed somatic variant 29748005 circulating tumour NS ENSP00000492462.1:p.Val130Leu ENST00000638463.1:c.388G>C 7:g.55155946G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0749 2107988 1985849 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003783-T01-IM5 2720274 2579095 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787534 COSM6191454 174320351 c.457T>C p.F153L Substitution - Missense 38 7:55156601-55156601 + - PATHOGENIC .99231 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000492462.1:p.Phe153Leu ENST00000638463.1:c.457T>C 7:g.55156601T>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-DU-A7TD-01 2339610 2204593 central_nervous_system brain NS NS glioma NS NS NS y COSV99294781 COSM8258176 174371531 c.209A>T p.Q70L Substitution - Missense 38 7:55154090-55154090 + - PATHOGENIC .97144 Confirmed somatic variant 545 NS primary 52 ENSP00000492462.1:p.Gln70Leu ENST00000638463.1:c.209A>T 7:g.55154090A>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 Br112X 1313001 1223910 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 18772396 xenograft primary 48 ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-CV-6961-01 2193755 2062033 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51839851 COSM7340115 174347180 c.500C>A p.P167Q Substitution - Missense 38 7:55156644-55156644 + - PATHOGENIC .76649 Confirmed somatic variant 627 NS NS 61 ENSP00000492462.1:p.Pro167Gln ENST00000638463.1:c.500C>A 7:g.55156644C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1690853 1690853 1599120 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51769792 COSM236670 174333561 c.858C>A p.S286R Substitution - Missense 38 7:55160316-55160316 + - NEUTRAL .35843 Confirmed somatic variant 22270724 surgery - NOS recurrent 52 ENSP00000492462.1:p.Ser286Arg ENST00000638463.1:c.858C>A 7:g.55160316C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 DUMC-05 2748702 2607405 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 29802247 surgery fresh/frozen NS 51 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 Br213T 1313043 1223952 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 18772396 surgery - NOS primary 71 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 B72-S1 2732506 2591266 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 174333195 c.470C>T p.T157I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 29244145 surgery fresh/frozen primary 76.6 ENSP00000492462.1:p.Thr157Ile ENST00000638463.1:c.470C>T 7:g.55156614C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 M702PT 2671818 2531377 pleura NS NS NS mesothelioma epithelial NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26928227 surgery fresh/frozen primary 30 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0002999-T01-IM3 2783044 2640827 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 174327537 c.137G>A p.R46H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28825054 surgery-fixed primary 57 ENSP00000492462.1:p.Arg46His ENST00000638463.1:c.137G>A 7:g.55154018G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0007037-T01-IM5 2830039 2685854 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843415 COSM6955777 174355508 c.621C>A p.N207K Substitution - Missense 38 7:55157694-55157694 + - PATHOGENIC .97853 Confirmed somatic variant 30205045 surgery-fixed metastasis 57 ENSP00000492462.1:p.Asn207Lys ENST00000638463.1:c.621C>A 7:g.55157694C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 238 2131812 2005876 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 23619168 fresh/frozen - NOS NS 50 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-DA-A3F3-06 2121581 1995817 skin NS NS NS malignant_melanoma NS NS NS y COSV51816429 COSM1698693 174334855 c.1192A>G p.N398D Substitution - Missense 38 7:55165367-55165367 + - NEUTRAL .4812 Confirmed somatic variant 540 NS NS 52 ENSP00000492462.1:p.Asn398Asp ENST00000638463.1:c.1192A>G 7:g.55165367A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-14-0866-01 2178121 2046419 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99295486 COSM7482458 174345277 c.521C>T p.S174F Substitution - Missense 38 7:55156764-55156764 + - NEUTRAL .25937 Confirmed somatic variant 329 NS NS 55 ENSP00000492462.1:p.Ser174Phe ENST00000638463.1:c.521C>T 7:g.55156764C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MELA_34952 2760718 2619251 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV51785510 COSM6957413 174317862 c.484G>A p.D162N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 30178487 surgery fresh/frozen metastasis 25 ENSP00000492462.1:p.Asp162Asn ENST00000638463.1:c.484G>A 7:g.55156628G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0750 2107989 1985850 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51807036 COSM2151966 174334262 c.1169C>G p.P390R Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99615 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Pro390Arg ENST00000638463.1:c.1169C>G 7:g.55165344C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1194732 1194732 1106627 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-32-1970-01 1338089 1248474 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-26-5139 2108061 1985922 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51840469 COSM2157152 174371227 c.1265G>T p.C422F Substitution - Missense 38 7:55171177-55171177 + - PATHOGENIC .98352 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Cys422Phe ENST00000638463.1:c.1265G>T 7:g.55171177G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 T1849 2658271 2518430 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51794659 COSM6652247 174343687 c.1102C>T p.R368W Substitution - Missense 38 7:55163821-55163821 + - PATHOGENIC .97962 Confirmed somatic variant 27149842 NS NS 79.25 ENSP00000492462.1:p.Arg368Trp ENST00000638463.1:c.1102C>T 7:g.55163821C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 10677523 2751151 2609847 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV105822270 COSM9522396 174341636 c.1166G>C p.C389S Substitution - Missense 38 7:55165341-55165341 + - Confirmed somatic variant 29748005 circulating tumour NS ENSP00000492462.1:p.Cys389Ser ENST00000638463.1:c.1166G>C 7:g.55165341G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-BR-8680-01 2197966 2066244 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51785413 COSM1176673 174327537 c.137G>A p.R46H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 541 NS NS 45 ENSP00000492462.1:p.Arg46His ENST00000638463.1:c.137G>A 7:g.55154018G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2014_Lung_sq_82_T 2744953 2603656 lung NS NS NS carcinoma NS NS NS y COSV51818649 COSM7238502 174375907 c.744G>T p.K248N Substitution - Missense 38 7:55160202-55160202 + - PATHOGENIC .92978 Confirmed somatic variant 583 NS primary 62 ENSP00000492462.1:p.Lys248Asn ENST00000638463.1:c.744G>T 7:g.55160202G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV99296117 COSM7998157 174346414 c.1332G>A p.M444I Substitution - Missense 38 7:55173013-55173013 + - NEUTRAL .06549 Confirmed somatic variant 540 NS NS 90 ENSP00000492462.1:p.Met444Ile ENST00000638463.1:c.1332G>A 7:g.55173013G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-DU-7006-01 2194244 2062522 central_nervous_system brain NS NS glioma NS NS NS y COSV51800797 COSM3412178 174330193 c.137G>C p.R46P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 545 NS NS 60 ENSP00000492462.1:p.Arg46Pro ENST00000638463.1:c.137G>C 7:g.55154018G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 R056-I1 2813481 2669873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 42 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV51778830 COSM1698691 174322993 c.580G>A p.E194K Substitution - Missense 38 7:55156823-55156823 + - PATHOGENIC .99571 Confirmed somatic variant 540 NS NS 90 ENSP00000492462.1:p.Glu194Lys ENST00000638463.1:c.580G>A 7:g.55156823G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-27-2528-01 1338071 1248456 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 surgery fresh/frozen NS 62 ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0007037-T01-IM5 2723412 2582233 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843415 COSM6955777 174355508 c.621C>A p.N207K Substitution - Missense het 38 7:55157694-55157694 + - PATHOGENIC .97853 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Asn207Lys ENST00000638463.1:c.621C>A 7:g.55157694C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0007381-T01-IM5 2723717 2582538 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51814979 COSM6957934 174357041 c.717A>G p.I239M Substitution - Missense het 38 7:55160175-55160175 + - NEUTRAL .42702 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Ile239Met ENST00000638463.1:c.717A>G 7:g.55160175A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 W016-S2 2732511 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 Br215T 1313044 1223953 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51785554 COSM21688 174319529 c.353G>T p.R118L Substitution - Missense het 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 18772396 surgery - NOS primary 50 ENSP00000492462.1:p.Arg118Leu ENST00000638463.1:c.353G>T 7:g.55155911G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 EXTERN_MELA_20140924_131 2839485 2695251 skin scalp NS NS malignant_melanoma NS NS NS y COSV51806564 COSM6920868 174327986 c.1388G>A p.R463Q Substitution - Missense 38 7:55173069-55173069 + - PATHOGENIC .99699 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000492462.1:p.Arg463Gln ENST00000638463.1:c.1388G>A 7:g.55173069G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-DK-AA75-01 2385754 2248586 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51771467 COSM7104388 174336061 c.459C>A p.F153L Substitution - Missense 38 7:55156603-55156603 + - PATHOGENIC .96682 Confirmed somatic variant 413 NS primary 82 ENSP00000492462.1:p.Phe153Leu ENST00000638463.1:c.459C>A 7:g.55156603C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 174322412 c.169A>C p.T57P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Thr57Pro ENST00000638463.1:c.169A>C 7:g.55154050A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0009852-T01-IM5 2725690 2584511 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51768139 COSM21685 174320891 c.248C>A p.A83D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Asp ENST00000638463.1:c.248C>A 7:g.55154129C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0008215-T01-IM5 2724369 2583190 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51834499 COSM6845063 174319637 c.346G>A p.G116S Substitution - Missense het 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Gly116Ser ENST00000638463.1:c.346G>A 7:g.55155904G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0008179-T01-IM5 2724346 2583167 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 174325395 c.1156G>A p.V386I Substitution - Missense het 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Val386Ile ENST00000638463.1:c.1156G>A 7:g.55165331G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 T_CCA_SG_13 2688086 2547068 biliary_tract bile_duct NS NS carcinoma NS NS NS y COSV51803429 COSM7002279 174329888 c.662G>A p.R221H Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .9961 Confirmed somatic variant 653 NS primary 60 ENSP00000492462.1:p.Arg221His ENST00000638463.1:c.662G>A 7:g.55157735G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003108-T01-IM5 2719604 2578425 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51866279 COSM6926300 174322028 c.47G>A p.R16H Substitution - Missense het 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000492462.1:p.Arg16His ENST00000638463.1:c.47G>A 7:g.55152582G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-FG-A4MU-01 2194395 2062673 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 58 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0876 2107991 1985852 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801732 COSM3923812 174370098 c.473C>T p.S158F Substitution - Missense 38 7:55156617-55156617 + - NEUTRAL .433 Confirmed somatic variant 540 NS NS 68 ENSP00000492462.1:p.Ser158Phe ENST00000638463.1:c.473C>T 7:g.55156617C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0008179-T02-IM5 2830115 2685930 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51799199 COSM1251020 174325395 c.1156G>A p.V386I Substitution - Missense 38 7:55165331-55165331 + - PATHOGENIC .99683 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000492462.1:p.Val386Ile ENST00000638463.1:c.1156G>A 7:g.55165331G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 SK01600_P 1951898 1838690 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51835132 COSM1600351 174364670 c.359G>C p.C120S Substitution - Missense het 38 7:55155917-55155917 + - PATHOGENIC .99486 Confirmed somatic variant 23441165 surgery - NOS primary 57 ENSP00000492462.1:p.Cys120Ser ENST00000638463.1:c.359G>C 7:g.55155917G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-BH-A18U-01 1899961 1788645 breast NS NS NS carcinoma NS NS NS y COSV99294745 COSM7670588 174356630 c.151G>A p.E51K Substitution - Missense 38 7:55154032-55154032 + - PATHOGENIC .97243 Confirmed somatic variant 414 fresh/frozen - NOS primary 72 ENSP00000492462.1:p.Glu51Lys ENST00000638463.1:c.151G>A 7:g.55154032G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-32-1982-01 1338091 1248476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 76 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-BB-A5HY-01 2385721 2248553 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99289265 COSM8389919 174385120 c.637G>C p.A213P Substitution - Missense 38 7:55157710-55157710 + - PATHOGENIC .9183 Confirmed somatic variant 627 NS primary 64 ENSP00000492462.1:p.Ala213Pro ENST00000638463.1:c.637G>C 7:g.55157710G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51865345 COSM6970489 174390470 c.559G>A p.D187N Substitution - Missense het 38 7:55156802-55156802 + - PATHOGENIC .91392 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Asp187Asn ENST00000638463.1:c.559G>A 7:g.55156802G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2014_Lung_sq_15_T 2744886 2603589 lung NS NS NS carcinoma NS NS NS y COSV51805367 COSM3950642 174350112 c.421G>A p.D141N Substitution - Missense 38 7:55156565-55156565 + - PATHOGENIC .82248 Confirmed somatic variant 583 NS primary 72 ENSP00000492462.1:p.Asp141Asn ENST00000638463.1:c.421G>A 7:g.55156565G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0011226-T01-IM5 2726843 2585664 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51842174 COSM6979569 174329316 c.992A>T p.D331V Substitution - Missense het 38 7:55161610-55161610 + - PATHOGENIC .78722 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Asp331Val ENST00000638463.1:c.992A>T 7:g.55161610A>T LAMC3 ENST00000361069.8 4728 6494 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV63091766 COSM4697377 110009006 c.2353C>T p.R785C Substitution - Missense 38 9:131066965-131066965 + - PATHOGENIC .96189 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000354360.4:p.Arg785Cys ENST00000361069.8:c.2353C>T 9:g.131066965C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787547 COSM6191455 174320357 c.508T>C p.F170L Substitution - Missense 38 7:55156652-55156652 + - PATHOGENIC .98052 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000492462.1:p.Phe170Leu ENST00000638463.1:c.508T>C 7:g.55156652T>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-28-1752-01 2178270 2046568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 42 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-28-1752-01 2178270 2046568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 42 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0155-01 1337821 1248206 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 174321914 c.292C>T p.H98Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 surgery fresh/frozen NS 61 ENSP00000492462.1:p.His98Tyr ENST00000638463.1:c.292C>T 7:g.55155850C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 CHG-100T 2634282 2494678 liver NS NS NS other neoplasm NS NS y COSV51842976 COSM6287773 174318179 c.734G>A p.R245H Substitution - Missense 38 7:55160192-55160192 + - PATHOGENIC .98594 Confirmed somatic variant 660 NS primary 65 ENSP00000492462.1:p.Arg245His ENST00000638463.1:c.734G>A 7:g.55160192G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787571 COSM6191458 174320370 c.1379T>C p.L460P Substitution - Missense 38 7:55173060-55173060 + - PATHOGENIC .99634 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000492462.1:p.Leu460Pro ENST00000638463.1:c.1379T>C 7:g.55173060T>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0174-01 1910190 1798481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 fresh/frozen - NOS primary 54 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 SJHYPO052-R 2590153 2451283 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 174325727 c.661C>T p.R221C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 23334668 blood-bone marrow recurrent 16.3 ENSP00000492462.1:p.Arg221Cys ENST00000638463.1:c.661C>T 7:g.55157734C>T ZFYVE9 ENST00000287727.7 4278 6775 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV55095322 COSM910631 101104585 c.3397C>T p.R1133W Substitution - Missense 38 1:52303884-52303884 + - PATHOGENIC .76999 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000287727.3:p.Arg1133Trp ENST00000287727.7:c.3397C>T 1:g.52303884C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 EXTERN_MELA_20140924_131 2839485 2695251 skin scalp NS NS malignant_melanoma NS NS NS y COSV104576577 COSM9396332 174335092 c.773C>T p.S258L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Confirmed somatic variant 28467829 surgery fresh/frozen primary ENSP00000492462.1:p.Ser258Leu ENST00000638463.1:c.773C>T 7:g.55160231C>T DCAF4_ENST00000509153 ENST00000509153.5 1308 20229 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105912372 COSM10012834 144258728 c.320G>A p.R107Q Substitution - Missense 38 14:72940346-72940346 + - NEUTRAL .14934 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000426178.1:p.Arg107Gln ENST00000509153.5:c.320G>A 14:g.72940346G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 LICA-CN-HCC055T 2634102 2494498 liver NS NS NS other neoplasm NS NS y COSV51829036 COSM5823994 174344852 c.383G>C p.R128P Substitution - Missense 38 7:55155941-55155941 + - PATHOGENIC .84442 Confirmed somatic variant 660 NS primary 65 ENSP00000492462.1:p.Arg128Pro ENST00000638463.1:c.383G>C 7:g.55155941G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0142-01 2120247 1994483 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 81 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0007897-T01-IM5 2724108 2582929 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0010610-T01-IM5 2726309 2585130 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51839766 COSM6975560 174326123 c.1246C>G p.P416A Substitution - Missense het 38 7:55165421-55165421 + - NEUTRAL .24318 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Pro416Ala ENST00000638463.1:c.1246C>G 7:g.55165421C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1194726 1194726 1106621 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MSU4-c 2809981 2666643 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV99291971 COSM9172239 174349159 c.1202T>C p.V401A Substitution - Missense 38 7:55165377-55165377 + - PATHOGENIC .99812 Confirmed somatic variant 26336987 surgery fresh/frozen primary 76 ENSP00000492462.1:p.Val401Ala ENST00000638463.1:c.1202T>C 7:g.55165377T>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-D3-A8GC-06 2262878 2129862 skin NS NS NS malignant_melanoma NS NS NS y COSV51822525 COSM6922832 174358283 c.722C>T p.S241F Substitution - Missense 38 7:55160180-55160180 + - .61329 Confirmed somatic variant 540 NS NS 48 ENSP00000492462.1:p.Ser241Phe ENST00000638463.1:c.722C>T 7:g.55160180C>T TRMT10B_ENST00000377754 ENST00000377754.6 666 26454 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105877142 COSM10012898 115317423 c.317G>C p.S106T Substitution - Missense 38 9:37769969-37769969 + - .6772 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000366983.2:p.Ser106Thr ENST00000377754.6:c.317G>C 9:g.37769969G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 B105-0-Tumor 2185749 2054046 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51776529 COSM1755314 174369526 c.1262G>A p.G421E Substitution - Missense 38 7:55165437-55165437 + - PATHOGENIC .99581 Confirmed somatic variant 581 NS NS ENSP00000492462.1:p.Gly421Glu ENST00000638463.1:c.1262G>A 7:g.55165437G>A LAMC3 ENST00000361069.8 4728 6494 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV62654689 COSM5482252 110013116 c.4052G>A p.R1351Q Substitution - Missense 38 9:131085545-131085545 + - NEUTRAL .01493 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000354360.4:p.Arg1351Gln ENST00000361069.8:c.4052G>A 9:g.131085545G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0174-01 1910190 1798481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51773690 COSM3412198 174380386 c.1223G>A p.G408D Substitution - Missense 38 7:55165398-55165398 + - NEUTRAL .00947 Confirmed somatic variant 329 fresh/frozen - NOS primary 54 ENSP00000492462.1:p.Gly408Asp ENST00000638463.1:c.1223G>A 7:g.55165398G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-25-2404-01 1474989 1398688 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV99292585 COSM7509017 174333800 c.763G>A p.V255M Substitution - Missense 38 7:55160221-55160221 + - PATHOGENIC .98193 Confirmed somatic variant 21720365 331 NS primary 38 ENSP00000492462.1:p.Val255Met ENST00000638463.1:c.763G>A 7:g.55160221G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-25-2404-01 1474989 1398688 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV99292585 COSM7509017 174333800 c.763G>A p.V255M Substitution - Missense 38 7:55160221-55160221 + - PATHOGENIC .98193 Confirmed somatic variant 331 NS primary 38 ENSP00000492462.1:p.Val255Met ENST00000638463.1:c.763G>A 7:g.55160221G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 T1748 2658268 2518427 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51796395 COSM6652238 174375829 c.626C>T p.T209M Substitution - Missense 38 7:55157699-55157699 + - PATHOGENIC .97374 Confirmed somatic variant 27149842 NS NS 85.08 ENSP00000492462.1:p.Thr209Met ENST00000638463.1:c.626C>T 7:g.55157699C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0002659-T01-IM3 2718905 2577726 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51775381 COSM6923532 174366565 c.431C>G p.S144C Substitution - Missense het 38 7:55156575-55156575 + - PATHOGENIC .99062 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Ser144Cys ENST00000638463.1:c.431C>G 7:g.55156575C>G PLAA_ENST00000520884 ENST00000520884.5 1830 9043 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105935379 COSM10012842 147772295 c.955C>T p.H319Y Substitution - Missense 38 9:26923262-26923262 - - PATHOGENIC .95978 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000429372.1:p.His319Tyr ENST00000520884.5:c.955C>T 9:g.26923262G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 J80_T 2194988 2063266 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51805367 COSM3950642 174350112 c.421G>A p.D141N Substitution - Missense 38 7:55156565-55156565 + - PATHOGENIC .82248 Confirmed somatic variant 583 NS NS ENSP00000492462.1:p.Asp141Asn ENST00000638463.1:c.421G>A 7:g.55156565G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 Br124X 1313013 1223922 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 xenograft primary 44 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003108-T01-IM5 2829558 2685373 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51866279 COSM6926300 174322028 c.47G>A p.R16H Substitution - Missense 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 30205045 surgery-fixed metastasis 37 ENSP00000492462.1:p.Arg16His ENST00000638463.1:c.47G>A 7:g.55152582G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 EX01T 2653305 2513432 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS primary 58.5 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 SC-her2-051 2313868 2179064 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51850832 COSM4943273 174391885 c.222C>A p.N74K Substitution - Missense 38 7:55154103-55154103 + - PATHOGENIC .93631 Confirmed somatic variant 24185512 surgery fresh/frozen metastasis ENSP00000492462.1:p.Asn74Lys ENST00000638463.1:c.222C>A 7:g.55154103C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 14_S4 2902121 2756359 autonomic_ganglia NS NS NS neuroblastoma NS NS NS n COSV105863896 COSM9976114 174339360 c.200C>G p.T67S Substitution - Missense 38 7:55154081-55154081 + - PATHOGENIC .94747 Confirmed somatic variant 33381456 circulating tumour primary 7 ENSP00000492462.1:p.Thr67Ser ENST00000638463.1:c.200C>G 7:g.55154081C>G OR7C1_ENST00000248073 ENST00000248073.2 963 8373 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV50183885 COSM1390989 100399343 c.364C>T p.R122C Substitution - Missense 38 19:14799773-14799773 - - .5891 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000248073.2:p.Arg122Cys ENST00000248073.2:c.364C>T 19:g.14799773G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-2567-01 1337886 1248271 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51816377 COSM3412194 174319015 c.1168C>T p.P390S Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99531 Confirmed somatic variant 329 surgery fresh/frozen NS 65 ENSP00000492462.1:p.Pro390Ser ENST00000638463.1:c.1168C>T 7:g.55165343C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-14-1455-01 2178074 2046372 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 174333195 c.470C>T p.T157I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 NS NS 61 ENSP00000492462.1:p.Thr157Ile ENST00000638463.1:c.470C>T 7:g.55156614C>T LILRA6 ENST00000396365.6 1446 15495 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105838079 COSM10012776 121507034 c.787G>T p.D263Y Substitution - Missense 38 19:54240999-54240999 - - NEUTRAL .0038 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000379651.2:p.Asp263Tyr ENST00000396365.6:c.787G>T 19:g.54240999C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-14-1829-01 1338016 1248401 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 174333195 c.470C>T p.T157I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 surgery fresh/frozen NS 57 ENSP00000492462.1:p.Thr157Ile ENST00000638463.1:c.470C>T 7:g.55156614C>T KCND3_ENST00000369697 ENST00000369697.5 1911 6239 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105875997 COSM10012826 111161585 c.740C>T p.A247V Substitution - Missense 38 1:111981987-111981987 - - PATHOGENIC .96322 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000358711.1:p.Ala247Val ENST00000369697.5:c.740C>T 1:g.111981987G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 T3010 2658443 2518602 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 174328588 c.962G>A p.R321Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 74.08 ENSP00000492462.1:p.Arg321Gln ENST00000638463.1:c.962G>A 7:g.55161580G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 CGCRC167 2434467 2297344 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV105863924 COSM10049276 174341307 c.422A>T p.D141V Substitution - Missense 38 7:55156566-55156566 + - PATHOGENIC .89104 Confirmed somatic variant 26416732 surgery - NOS primary 81 ENSP00000492462.1:p.Asp141Val ENST00000638463.1:c.422A>T 7:g.55156566A>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-2557-01 1337877 1248262 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 76 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 IGC-03-1030 2662287 2522411 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51787961 COSM6530131 174350350 c.1277G>C p.G426A Substitution - Missense 38 7:55171189-55171189 + - PATHOGENIC .98448 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000492462.1:p.Gly426Ala ENST00000638463.1:c.1277G>C 7:g.55171189G>C CHN1_ENST00000409156 ENST00000409156.7 1302 1943 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105886981 COSM10012859 123972913 c.1246C>T p.R416W Substitution - Missense 38 2:174800172-174800172 - - PATHOGENIC .98155 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000386470.3:p.Arg416Trp ENST00000409156.7:c.1246C>T 2:g.174800172G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-VQ-A8P2-01 2339964 2204947 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51820069 COSM6652271 174328352 c.1313C>T p.P438L Substitution - Missense 38 7:55172994-55172994 + - PATHOGENIC .98245 Confirmed somatic variant 541 NS primary 68 ENSP00000492462.1:p.Pro438Leu ENST00000638463.1:c.1313C>T 7:g.55172994C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0006124-T01-IM5 2722503 2581324 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51842040 COSM6948138 174358877 c.459C>G p.F153L Substitution - Missense het 38 7:55156603-55156603 + - PATHOGENIC .96894 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000492462.1:p.Phe153Leu ENST00000638463.1:c.459C>G 7:g.55156603C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-12-0707-01 2178095 2046393 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 174323026 c.191A>G p.Y64C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 329 NS NS 55 ENSP00000492462.1:p.Tyr64Cys ENST00000638463.1:c.191A>G 7:g.55154072A>G OR56A1_ENST00000641423 ENST00000641423.1 945 14781 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105883756 COSM10012845 173595549 c.755T>G p.L252R Substitution - Missense 38 11:6026938-6026938 - - NEUTRAL .24245 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000493266.1:p.Leu252Arg ENST00000641423.1:c.755T>G 11:g.6026938A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0004510-T01-IM5 2720910 2579731 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 S06-38853-TP 2366573 2229456 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51796296 COSM4992967 174370290 c.1022G>A p.R341K Substitution - Missense het 38 7:55163741-55163741 + - PATHOGENIC .992 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000492462.1:p.Arg341Lys ENST00000638463.1:c.1022G>A 7:g.55163741G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-2563-01 1337882 1248267 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 174325029 c.136C>T p.R46C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000492462.1:p.Arg46Cys ENST00000638463.1:c.136C>T 7:g.55154017C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0002999-T01-IM3 2719208 2578029 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 174327537 c.137G>A p.R46H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Arg46His ENST00000638463.1:c.137G>A 7:g.55154018G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-DU-A5TT-01 2194423 2062701 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 70 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0007813-T01-IM5 2724038 2582859 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767730 COSM6548312 174326029 c.44G>T p.G15V Substitution - Missense het 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000492462.1:p.Gly15Val ENST00000638463.1:c.44G>T 7:g.55152579G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-EE-A2MR-06 2121688 1995924 skin NS NS NS malignant_melanoma NS NS NS y COSV51788720 COSM3639737 174371240 c.916C>T p.P306S Substitution - Missense 38 7:55161534-55161534 + - NEUTRAL .03494 Confirmed somatic variant 540 NS NS 61 ENSP00000492462.1:p.Pro306Ser ENST00000638463.1:c.916C>T 7:g.55161534C>T BRSK1_ENST00000590333 ENST00000590333.5 2385 18994 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105897071 COSM10012785 163317968 c.484T>A p.F162I Substitution - Missense 38 19:55289598-55289598 + - PATHOGENIC .95752 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000468190.1:p.Phe162Ile ENST00000590333.5:c.484T>A 19:g.55289598T>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-OX-A56R-01 2178260 2046558 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 68 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0005127-T01-IM5 2721532 2580353 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51802355 COSM6941144 174320405 c.536C>T p.P179L Substitution - Missense het 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000492462.1:p.Pro179Leu ENST00000638463.1:c.536C>T 7:g.55156779C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2697837 2697837 2556741 breast NS NS NS carcinoma NS NS NS n COSV51811430 COSM6906106 174383731 c.647A>G p.N216S Substitution - Missense 38 7:55157720-55157720 + - PATHOGENIC .99784 Confirmed somatic variant 29349598 NS NS ENSP00000492462.1:p.Asn216Ser ENST00000638463.1:c.647A>G 7:g.55157720A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0007504-T01-IM5 2723789 2582610 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P147 2072600 1951955 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 44 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 Br140X 1313029 1223938 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 xenograft primary 41 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 7C 2549418 2410873 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51792433 COSM6966446 174352434 c.1144G>A p.G382S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 646 NS primary 66 ENSP00000492462.1:p.Gly382Ser ENST00000638463.1:c.1144G>A 7:g.55165319G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0004944-T02-IM5 2721354 2580175 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843300 COSM6949613 174355469 c.319G>T p.A107S Substitution - Missense het 38 7:55155877-55155877 + - NEUTRAL .06397 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000492462.1:p.Ala107Ser ENST00000638463.1:c.319G>T 7:g.55155877G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0004400-T01-IM5 2720811 2579632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003955-T01-IM3 2719291 2578112 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51841887 COSM6949297 174338520 c.1336G>A p.G446R Substitution - Missense het 38 7:55173017-55173017 + - PATHOGENIC .99728 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Gly446Arg ENST00000638463.1:c.1336G>A 7:g.55173017G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 SJALL040461-R 2824036 2679864 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_B_cell_leukaemia NS NS y COSV104576718 COSM9280424 174333366 c.974G>A p.R325Q Substitution - Missense 38 7:55161592-55161592 + - PATHOGENIC .99386 Confirmed somatic variant 31697823 blood-bone marrow recurrent 11.64 ENSP00000492462.1:p.Arg325Gln ENST00000638463.1:c.974G>A 7:g.55161592G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 s_DS_scb_02_tumour 2861572 2716810 urinary_tract bladder NS NS carcinoma small_cell_carcinoma NS NS n COSV105109947 COSM9575249 174341073 c.55G>A p.G19S Substitution - Missense 38 7:55152590-55152590 + - PATHOGENIC .99676 Confirmed somatic variant 29180607 surgery-fixed NS 68 ENSP00000492462.1:p.Gly19Ser ENST00000638463.1:c.55G>A 7:g.55152590G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 PD6313a 1483843 1407469 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_ringed_sideroblasts NS n COSV51819755 COSM4384123 174391333 c.983A>C p.E328A Substitution - Missense 38 7:55161601-55161601 + - PATHOGENIC .82008 Confirmed somatic variant 24030381 NS NS ENSP00000492462.1:p.Glu328Ala ENST00000638463.1:c.983A>C 7:g.55161601A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0004400-T01-IM5 2720811 2579632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-28-5207-01 2120332 1994568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 71 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-14-1455 2108036 1985897 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 174333195 c.470C>T p.T157I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Thr157Ile ENST00000638463.1:c.470C>T 7:g.55156614C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-EE-A2MI-06 2121680 1995916 skin NS NS NS malignant_melanoma NS NS NS y COSV51783517 COSM3639743 174317597 c.1246C>T p.P416S Substitution - Missense 38 7:55165421-55165421 + - NEUTRAL .20892 Confirmed somatic variant 540 NS NS 43 ENSP00000492462.1:p.Pro416Ser ENST00000638463.1:c.1246C>T 7:g.55165421C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003739-T01-IM5 2720227 2579048 soft_tissue blood_vessel skin NS angiosarcoma NS NS NS n COSV51783517 COSM3639743 174317597 c.1246C>T p.P416S Substitution - Missense het 38 7:55165421-55165421 + - NEUTRAL .20892 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Pro416Ser ENST00000638463.1:c.1246C>T 7:g.55165421C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 ILMN13 2816773 2673124 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51797307 COSM1090871 174341516 c.692C>A p.S231Y Substitution - Missense 38 7:55160150-55160150 + - PATHOGENIC .98943 Confirmed somatic variant 29937994 surgery fresh/frozen NS 54 ENSP00000492462.1:p.Ser231Tyr ENST00000638463.1:c.692C>A 7:g.55160150C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0011544-T01-IM5 2727116 2585937 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51774354 COSM6981709 174390494 c.333G>C p.E111D Substitution - Missense het 38 7:55155891-55155891 + - PATHOGENIC .93673 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Glu111Asp ENST00000638463.1:c.333G>C 7:g.55155891G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0008450-T01-IM5 2724567 2583388 skin NS NS NS malignant_melanoma NS NS NS n COSV51822498 COSM3266565 174354571 c.299C>T p.S100L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ser100Leu ENST00000638463.1:c.299C>T 7:g.55155857C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 174320891 c.248C>A p.A83D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000492462.1:p.Ala83Asp ENST00000638463.1:c.248C>A 7:g.55154129C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 PTC-7C 2185970 2054267 thyroid NS NS NS other neoplasm NS NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 589 NS NS ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577026 COSM9413136 174399921 c.775G>C p.G259R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .4176 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000492462.1:p.Gly259Arg ENST00000638463.1:c.775G>C 7:g.55160233G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003350-T01-IM5 2719841 2578662 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51815967 COSM39522 174320843 c.37T>G p.C13G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Cys13Gly ENST00000638463.1:c.37T>G 7:g.55152572T>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-AM-5821-01 1651151 1565938 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV99291226 COSM7552389 174347646 c.506C>T p.A169V Substitution - Missense 38 7:55156650-55156650 + - PATHOGENIC .98971 Confirmed somatic variant 376 NS NS 68 ENSP00000492462.1:p.Ala169Val ENST00000638463.1:c.506C>T 7:g.55156650C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-76-6282-01 2120389 1994625 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51810174 COSM3412190 174326797 c.1094G>C p.C365S Substitution - Missense 38 7:55163813-55163813 + - PATHOGENIC .99637 Confirmed somatic variant 329 NS NS 63 ENSP00000492462.1:p.Cys365Ser ENST00000638463.1:c.1094G>C 7:g.55163813G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-RD-A7BT-01 2263044 2130028 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99295752 COSM8178996 174345352 c.97G>A p.G33S Substitution - Missense 38 7:55152632-55152632 + - PATHOGENIC .99504 Confirmed somatic variant 541 NS primary 66 ENSP00000492462.1:p.Gly33Ser ENST00000638463.1:c.97G>A 7:g.55152632G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577025 COSM9413133 174399908 c.708C>G p.S236R Substitution - Missense 38 7:55160166-55160166 + - NEUTRAL .15107 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000492462.1:p.Ser236Arg ENST00000638463.1:c.708C>G 7:g.55160166C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0649-01 1337849 1248234 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51791901 COSM2151461 174357400 c.373G>A p.G125R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .96902 Confirmed somatic variant 329 surgery fresh/frozen NS 73 ENSP00000492462.1:p.Gly125Arg ENST00000638463.1:c.373G>A 7:g.55155931G>A SLC13A2 ENST00000444914.7 1926 10917 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105903232 COSM10012975 130101820 c.588G>A p.M196I Substitution - Missense 38 17:28490773-28490773 + - PATHOGENIC .96983 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000392411.3:p.Met196Ile ENST00000444914.7:c.588G>A 17:g.28490773G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2757166 2757166 2615808 haematopoietic_and_lymphoid_tissue skin NS NS lymphoid_neoplasm mycosis_fungoides-Sezary_syndrome NS NS y COSV104576496 COSM9308820 174368668 c.628G>A p.D210N Substitution - Missense 38 7:55157701-55157701 + - PATHOGENIC .96223 Confirmed somatic variant 26551670 blood-bone marrow secondary ENSP00000492462.1:p.Asp210Asn ENST00000638463.1:c.628G>A 7:g.55157701G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-12-3650-01 2120284 1994520 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 46 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-2565-01 1337884 1248269 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772147 COSM375343 174337812 c.1316C>G p.S439C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000492462.1:p.Ser439Cys ENST00000638463.1:c.1316C>G 7:g.55172997C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 SJERG020309_D1 2565683 2427077 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51802051 COSM5986345 174361231 c.1375G>A p.G459S Substitution - Missense 38 7:55173056-55173056 + - PATHOGENIC .98464 Confirmed somatic variant 27776115 blood-bone marrow primary 17.5 ENSP00000492462.1:p.Gly459Ser ENST00000638463.1:c.1375G>A 7:g.55173056G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-14-0786-01 1337986 1248371 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 PCSI_0590_Pa_P_526 2507081 2369417 pancreas NS NS NS carcinoma NS NS NS y COSV51771539 COSM5760860 174395148 c.1087A>G p.I363V Substitution - Missense 38 7:55163806-55163806 + - NEUTRAL .01956 Confirmed somatic variant 382 NS primary 73 ENSP00000492462.1:p.Ile363Val ENST00000638463.1:c.1087A>G 7:g.55163806A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 B103-S1 2732514 2591270 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV104576423 COSM9498532 174327588 c.1083G>T p.M361I Substitution - Missense 38 7:55163802-55163802 + - PATHOGENIC .93931 Confirmed somatic variant 29244145 surgery fresh/frozen primary 74.3 ENSP00000492462.1:p.Met361Ile ENST00000638463.1:c.1083G>T 7:g.55163802G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0008927-T01-IM5 2724943 2583764 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51768139 COSM21685 174320891 c.248C>A p.A83D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Asp ENST00000638463.1:c.248C>A 7:g.55154129C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-AA-3982-01 1651089 1565876 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51769747 COSM297803 174351694 c.289G>C p.D97H Substitution - Missense 38 7:55155847-55155847 + - PATHOGENIC .99461 Confirmed somatic variant 22810696 376 NS NS 75 ENSP00000492462.1:p.Asp97His ENST00000638463.1:c.289G>C 7:g.55155847G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-DU-7292-01 2194421 2062699 central_nervous_system brain NS NS glioma NS NS NS y COSV51800797 COSM3412178 174330193 c.137G>C p.R46P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 545 NS NS 69 ENSP00000492462.1:p.Arg46Pro ENST00000638463.1:c.137G>C 7:g.55154018G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-12-3650-01 2120284 1994520 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51845825 COSM3412188 174330169 c.662G>T p.R221L Substitution - Missense 38 7:55157735-55157735 + - PATHOGENIC .99702 Confirmed somatic variant 329 NS NS 46 ENSP00000492462.1:p.Arg221Leu ENST00000638463.1:c.662G>T 7:g.55157735G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-DD-A73A-01 2194652 2062930 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51846765 COSM4916543 174325696 c.614C>G p.P205R Substitution - Missense 38 7:55157687-55157687 + - PATHOGENIC .99735 Confirmed somatic variant 628 NS NS 71 ENSP00000492462.1:p.Pro205Arg ENST00000638463.1:c.614C>G 7:g.55157687C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0004225-T01-IM5 2720632 2579453 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV51771772 COSM6934070 174398902 c.681T>A p.H227Q Substitution - Missense het 38 7:55160139-55160139 + - PATHOGENIC .93122 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.His227Gln ENST00000638463.1:c.681T>A 7:g.55160139T>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-28-1757-01 2178083 2046381 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 71 ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-EE-A29D-06 2121635 1995871 skin NS NS NS malignant_melanoma NS NS NS y COSV51799159 COSM747427 174345260 c.1148C>T p.P383L Substitution - Missense 38 7:55165323-55165323 + - PATHOGENIC .95834 Confirmed somatic variant 540 NS NS 87 ENSP00000492462.1:p.Pro383Leu ENST00000638463.1:c.1148C>T 7:g.55165323C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 R074-R1 2813496 2669888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99297135 COSM9212199 174339656 c.247G>T p.A83S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 41 ENSP00000492462.1:p.Ala83Ser ENST00000638463.1:c.247G>T 7:g.55154128G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577024 COSM9413134 174399904 c.704T>A p.V235D Substitution - Missense 38 7:55160162-55160162 + - PATHOGENIC .92743 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000492462.1:p.Val235Asp ENST00000638463.1:c.704T>A 7:g.55160162T>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 007 2640411 2500713 lung NS NS NS carcinoma bronchioloalveolar_adenocarcinoma NS NS y COSV51815598 COSM6471954 174337590 c.707G>T p.S236I Substitution - Missense 38 7:55160165-55160165 + - NEUTRAL .44157 Confirmed somatic variant 27545006 fixed - NOS NS 57 ENSP00000492462.1:p.Ser236Ile ENST00000638463.1:c.707G>T 7:g.55160165G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 PCA1587 2861424 2716668 prostate NS NS NS carcinoma NS NS NS n COSV105111146 COSM9581090 174386677 c.1261G>C p.G421R Substitution - Missense 38 7:55165436-55165436 + - PATHOGENIC .99177 Confirmed somatic variant 32268276 circulating tumour NS ENSP00000492462.1:p.Gly421Arg ENST00000638463.1:c.1261G>C 7:g.55165436G>C TTN_ENST00000342175 ENST00000342175.11 81357 12403 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105912072 COSM10012820 104615611 c.9405A>T p.K3135N Substitution - Missense 38 2:178766541-178766541 - - PATHOGENIC .90433 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000340554.6:p.Lys3135Asn ENST00000342175.11:c.9405A>T 2:g.178766541T>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 S10-24679-TP 2366580 2229463 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51808100 COSM4992964 174385090 c.200C>T p.T67I Substitution - Missense het 38 7:55154081-55154081 + - PATHOGENIC .9224 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000492462.1:p.Thr67Ile ENST00000638463.1:c.200C>T 7:g.55154081C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0008927-T01-IM5 2724943 2583764 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51767495 COSM35752 174325029 c.136C>T p.R46C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Arg46Cys ENST00000638463.1:c.136C>T 7:g.55154017C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GBM7-I2 2813444 2669836 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99293015 COSM9210724 174341007 c.1253G>C p.C418S Substitution - Missense 38 7:55165428-55165428 + - PATHOGENIC .99908 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000492462.1:p.Cys418Ser ENST00000638463.1:c.1253G>C 7:g.55165428G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576891 COSM9396331 174334548 c.782A>C p.K261T Substitution - Missense 38 7:55160240-55160240 + - NEUTRAL .10442 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000492462.1:p.Lys261Thr ENST00000638463.1:c.782A>C 7:g.55160240A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51776247 COSM6110417 174336954 c.775G>A p.G259R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000492462.1:p.Gly259Arg ENST00000638463.1:c.775G>A 7:g.55160233G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577027 COSM9413135 174337528 c.776G>A p.G259E Substitution - Missense 38 7:55160234-55160234 + - NEUTRAL .11765 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000492462.1:p.Gly259Glu ENST00000638463.1:c.776G>A 7:g.55160234G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 CRC396 2730836 2589605 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV105863800 COSM10061888 174331254 c.1364C>G p.A455G Substitution - Missense 38 7:55173045-55173045 + - .53009 Confirmed somatic variant 26416732 xenograft metastasis 57 ENSP00000492462.1:p.Ala455Gly ENST00000638463.1:c.1364C>G 7:g.55173045C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 ATL020 2488648 2351297 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm adult_T_cell_lymphoma-leukaemia NS NS y COSV51770269 COSM5710629 174354619 c.397G>A p.G133R Substitution - Missense 38 7:55156541-55156541 + - PATHOGENIC .9949 Confirmed somatic variant 26437031 NS NS 63 ENSP00000492462.1:p.Gly133Arg ENST00000638463.1:c.397G>A 7:g.55156541G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 CHG-12-12649T 2634294 2494690 liver NS NS NS other neoplasm NS NS y COSV51767687 COSM6191352 174317778 c.1129G>A p.A377T Substitution - Missense 38 7:55165304-55165304 + - PATHOGENIC .98656 Confirmed somatic variant 660 NS primary 50 ENSP00000492462.1:p.Ala377Thr ENST00000638463.1:c.1129G>A 7:g.55165304G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0001042-T01-IM3 2716511 2575332 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51787557 COSM6191456 174320363 c.719C>T p.T240I Substitution - Missense het 38 7:55160177-55160177 + - NEUTRAL .13103 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Thr240Ile ENST00000638463.1:c.719C>T 7:g.55160177C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 YUKLAB 2013569 1896201 skin NS NS NS malignant_melanoma NS NS NS y COSV51796177 COSM1698689 174361150 c.571A>T p.T191S Substitution - Missense het 38 7:55156814-55156814 + - PATHOGENIC .9893 Confirmed somatic variant 22842228 surgery fresh/frozen metastasis 84 ENSP00000492462.1:p.Thr191Ser ENST00000638463.1:c.571A>T 7:g.55156814A>T SPTBN1_ENST00000333896 ENST00000333896.5 6468 11275 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105886037 COSM10012863 106705456 c.1357G>T p.A453S Substitution - Missense 38 2:54625986-54625986 + - PATHOGENIC .98456 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000334156.5:p.Ala453Ser ENST00000333896.5:c.1357G>T 2:g.54625986G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0007018-T01-IM5 2723393 2582214 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765787 COSM2149971 174321914 c.292C>T p.H98Y Substitution - Missense het 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.His98Tyr ENST00000638463.1:c.292C>T 7:g.55155850C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0000785-T01-IM3 2715984 2574805 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767730 COSM6548312 174326029 c.44G>T p.G15V Substitution - Missense het 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Gly15Val ENST00000638463.1:c.44G>T 7:g.55152579G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0125-02 2120245 1994481 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 64 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-26-1439-01 2120320 1994556 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 63 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 EXTERN_MELA_20140514_002 2839308 2695074 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51866168 COSM3266611 174341055 c.1222G>A p.G408S Substitution - Missense 38 7:55165397-55165397 + - NEUTRAL .00559 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000492462.1:p.Gly408Ser ENST00000638463.1:c.1222G>A 7:g.55165397G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104576577 COSM9396332 174335092 c.773C>T p.S258L Substitution - Missense 38 7:55160231-55160231 + - NEUTRAL .23513 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000492462.1:p.Ser258Leu ENST00000638463.1:c.773C>T 7:g.55160231C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-2563 2108004 1985865 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 174325029 c.136C>T p.R46C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Arg46Cys ENST00000638463.1:c.136C>T 7:g.55154017C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 IGC-10-1053 2662337 2522461 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51767730 COSM6548312 174326029 c.44G>T p.G15V Substitution - Missense 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000492462.1:p.Gly15Val ENST00000638463.1:c.44G>T 7:g.55152579G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-EE-A3AB-06 2121693 1995929 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 174324320 c.550C>A p.Q184K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 540 NS NS 30 ENSP00000492462.1:p.Gln184Lys ENST00000638463.1:c.550C>A 7:g.55156793C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MELA_20076 2760731 2619264 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 174324320 c.550C>A p.Q184K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 30178487 surgery fresh/frozen metastasis 30 ENSP00000492462.1:p.Gln184Lys ENST00000638463.1:c.550C>A 7:g.55156793C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 18195 2422953 2285875 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV51779680 COSM1313184 174348858 c.533C>G p.T178S Substitution - Missense 38 7:55156776-55156776 + - PATHOGENIC .98418 Confirmed somatic variant 24469795 NS NS 61 ENSP00000492462.1:p.Thr178Ser ENST00000638463.1:c.533C>G 7:g.55156776C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-EA-A410-01 2262924 2129908 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51769145 COSM3266559 174356454 c.256G>A p.V86M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 415 NS primary 51 ENSP00000492462.1:p.Val86Met ENST00000638463.1:c.256G>A 7:g.55154137G>A ADAMTS19_ENST00000274487 ENST00000274487.8 3642 17111 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105859138 COSM10012952 98859069 c.3568G>T p.D1190Y Substitution - Missense 38 5:129737144-129737144 + - PATHOGENIC .98099 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000274487.5:p.Asp1190Tyr ENST00000274487.8:c.3568G>T 5:g.129737144G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1894611 1894611 1783303 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51837871 COSM1238072 174398205 c.1018C>T p.P340S Substitution - Missense hom 38 7:55163737-55163737 + - PATHOGENIC .99252 Confirmed somatic variant 23578570 surgery-fixed NS 33 ENSP00000492462.1:p.Pro340Ser ENST00000638463.1:c.1018C>T 7:g.55163737C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-AM-5820-01 1651150 1565937 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 376 NS NS 59 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2503528 2503528 2365878 autonomic_ganglia sinonasal_and_nasal_cavity NS NS olfactory_neuroblastoma NS NS NS n COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense het 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 27149458 surgery - NOS NS 44 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MTP18_T2 2875798 2730360 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 32796935 surgery-fixed NS 74 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A KIFC3 ENST00000541240.5 2547 6326 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65551650 COSM971903 154903134 c.760C>T p.R254W Substitution - Missense 38 16:57771269-57771269 - - PATHOGENIC .87712 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000442008.1:p.Arg254Trp ENST00000541240.5:c.760C>T 16:g.57771269G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-D1-A2G5-01 2198276 2066554 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99295137 COSM8817249 174358652 c.1255A>G p.T419A Substitution - Missense 38 7:55165430-55165430 + - PATHOGENIC .99619 Confirmed somatic variant 419 NS NS 50 ENSP00000492462.1:p.Thr419Ala ENST00000638463.1:c.1255A>G 7:g.55165430A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0004104-T01-IM5 2829691 2685506 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51846321 COSM6933335 174386013 c.1290T>G p.C430W Substitution - Missense 38 7:55171202-55171202 + - .63273 Confirmed somatic variant 30205045 surgery-fixed metastasis 32 ENSP00000492462.1:p.Cys430Trp ENST00000638463.1:c.1290T>G 7:g.55171202T>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0006290-T01-IM5 2722667 2581488 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51839751 COSM6949885 174337740 c.1308G>T p.K436N Substitution - Missense het 38 7:55172989-55172989 + - PATHOGENIC .95891 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000492462.1:p.Lys436Asn ENST00000638463.1:c.1308G>T 7:g.55172989G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GBM_IV-35 2354292 2218450 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-FR-A8YC-06 2263445 2130429 skin NS NS NS malignant_melanoma NS NS NS y COSV51772860 COSM5872872 174356472 c.65C>T p.P22L Substitution - Missense 38 7:55152600-55152600 + - PATHOGENIC .99115 Confirmed somatic variant 540 NS NS 78 ENSP00000492462.1:p.Pro22Leu ENST00000638463.1:c.65C>T 7:g.55152600C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-IR-A3LA-01 2193391 2061669 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51796224 COSM4844514 174361161 c.1030G>C p.V344L Substitution - Missense 38 7:55163749-55163749 + - PATHOGENIC .98124 Confirmed somatic variant 415 NS NS 60 ENSP00000492462.1:p.Val344Leu ENST00000638463.1:c.1030G>C 7:g.55163749G>C ABCC8_ENST00000644772 ENST00000644772.1 4812 59 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105879570 COSM10012873 177767703 c.2123T>C p.F708S Substitution - Missense 38 11:17427926-17427926 - - PATHOGENIC .98111 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000494321.1:p.Phe708Ser ENST00000644772.1:c.2123T>C 11:g.17427926A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-AX-A06F-01 2198328 2066606 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99294241 COSM8943299 174357642 c.92C>A p.A31D Substitution - Missense 38 7:55152627-55152627 + - PATHOGENIC .99353 Confirmed somatic variant 419 NS NS 59 ENSP00000492462.1:p.Ala31Asp ENST00000638463.1:c.92C>A 7:g.55152627C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2014_Lung_sq_06_T 2744877 2603580 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 77 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 RS33T 2653643 2513765 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS primary 67.09 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-BR-4256-01 2198141 2066419 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51797215 COSM145360 174331056 c.349G>A p.V117I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 541 NS NS 80 ENSP00000492462.1:p.Val117Ile ENST00000638463.1:c.349G>A 7:g.55155907G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003417-T01-IM5 2719901 2578722 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS n COSV51815967 COSM39522 174320843 c.37T>G p.C13G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Cys13Gly ENST00000638463.1:c.37T>G 7:g.55152572T>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 16678 1423698 1333726 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51812036 COSM48318 174379219 c.1171G>A p.A391T Substitution - Missense het 38 7:55165346-55165346 + - NEUTRAL .27484 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000492462.1:p.Ala391Thr ENST00000638463.1:c.1171G>A 7:g.55165346G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-AX-A06F-01 2198328 2066606 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51827490 COSM39163 174340256 c.1289G>A p.C430Y Substitution - Missense 38 7:55171201-55171201 + - PATHOGENIC .98251 Confirmed somatic variant 419 NS NS 59 ENSP00000492462.1:p.Cys430Tyr ENST00000638463.1:c.1289G>A 7:g.55171201G>A KIFC3_ENST00000465878 ENST00000465878.6 2064 6326 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV65551650 COSM971903 133981224 c.277C>T p.R93W Substitution - Missense 38 16:57771269-57771269 - - PATHOGENIC .87712 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000454659.1:p.Arg93Trp ENST00000465878.6:c.277C>T 16:g.57771269G>A HNRNPM ENST00000325495.8 2193 5046 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105881442 COSM10012792 103377838 c.548T>A p.I183N Substitution - Missense 38 19:8465433-8465433 + - PATHOGENIC .96736 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000325376.2:p.Ile183Asn ENST00000325495.8:c.548T>A 19:g.8465433T>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-16-0849-01 2178109 2046407 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 54 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1194735 1194735 1106630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T IFT22 ENST00000315322.8 558 21895 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105876048 COSM10012944 103632208 c.247G>A p.G83R Substitution - Missense 38 7:101316502-101316502 - - PATHOGENIC .98716 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000320359.4:p.Gly83Arg ENST00000315322.8:c.247G>A 7:g.101316502C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 Br306T 1313064 1223973 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 surgery - NOS primary 51 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T HIF1AN ENST00000299163.6 1050 17113 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105884710 COSM10012807 99667485 c.776T>C p.V259A Substitution - Missense 38 10:100545995-100545995 + - PATHOGENIC .99367 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000299163.4:p.Val259Ala ENST00000299163.6:c.776T>C 10:g.100545995T>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-EE-A2M7-06 2121673 1995909 skin NS NS NS malignant_melanoma NS NS NS y COSV51790699 COSM3639729 174344478 c.173G>A p.C58Y Substitution - Missense 38 7:55154054-55154054 + - PATHOGENIC .99369 Confirmed somatic variant 540 NS NS 66 ENSP00000492462.1:p.Cys58Tyr ENST00000638463.1:c.173G>A 7:g.55154054G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0006622-T01-IM5 2829996 2685811 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51845994 COSM5530405 174318236 c.1015G>A p.E339K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 30205045 surgery-fixed primary 43 ENSP00000492462.1:p.Glu339Lys ENST00000638463.1:c.1015G>A 7:g.55163734G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-19-1789-01 2178219 2046517 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51850088 COSM2156010 174345239 c.382C>T p.R128C Substitution - Missense 38 7:55155940-55155940 + - PATHOGENIC .91604 Confirmed somatic variant 329 NS NS 69 ENSP00000492462.1:p.Arg128Cys ENST00000638463.1:c.382C>T 7:g.55155940C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0006119-T01-IM5 2722498 2581319 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51836484 COSM6948259 174382955 c.239G>A p.S80N Substitution - Missense het 38 7:55154120-55154120 + - PATHOGENIC .95351 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000492462.1:p.Ser80Asn ENST00000638463.1:c.239G>A 7:g.55154120G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GBM7-I2 2813444 2669836 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 123 2748095 2606798 stomach NS NS NS carcinoma NS NS NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 683 NS primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T KIAA0100_ENST00000544884 ENST00000544884.5 6279 28960 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV101197296 COSM8902986 157096686 c.2741G>A p.R914H Substitution - Missense 38 17:28633987-28633987 - - PATHOGENIC .83007 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000446443.1:p.Arg914His ENST00000544884.5:c.2741G>A 17:g.28633987C>T C1RL_ENST00000544702 ENST00000544702.5 945 21265 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV56923985 COSM2101631 156655623 c.406C>T p.R136W Substitution - Missense 38 12:7101982-7101982 - - NEUTRAL .10223 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000441885.1:p.Arg136Trp ENST00000544702.5:c.406C>T 12:g.7101982G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0008262-T01-IM5 2724401 2583222 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T TTN_ENST00000342175 ENST00000342175.11 81357 12403 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV59957361 COSM130006 104705199 c.184C>T p.R62C Substitution - Missense 38 2:178802249-178802249 - - PATHOGENIC .99021 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000340554.6:p.Arg62Cys ENST00000342175.11:c.184C>T 2:g.178802249G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 R056-R1 2813482 2669874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289246 COSM8268187 174322063 c.170C>T p.T57I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 42 ENSP00000492462.1:p.Thr57Ile ENST00000638463.1:c.170C>T 7:g.55154051C>T PASD1 ENST00000370357.4 2322 20686 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105922292 COSM10012884 111128227 c.691G>A p.A231T Substitution - Missense 38 23:151648676-151648676 + - NEUTRAL .01056 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000359382.4:p.Ala231Thr ENST00000370357.4:c.691G>A X:g.151648676G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2625883 2625883 2486295 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51796381 COSM6191457 174375824 c.1249A>T p.N417Y Substitution - Missense 38 7:55165424-55165424 + - PATHOGENIC .99705 Confirmed somatic variant 25617745 surgery-fixed NS 61 ENSP00000492462.1:p.Asn417Tyr ENST00000638463.1:c.1249A>T 7:g.55165424A>T TTN_ENST00000342992 ENST00000342992.10 100272 12403 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105912072 COSM10012820 106847309 c.9543A>T p.K3181N Substitution - Missense 38 2:178766541-178766541 - - PATHOGENIC .90433 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000343764.6:p.Lys3181Asn ENST00000342992.10:c.9543A>T 2:g.178766541T>A TMPRSS11E ENST00000305363.8 1272 24465 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105896650 COSM10012861 103593274 c.1268T>A p.I423N Substitution - Missense 38 4:68496800-68496800 + - PATHOGENIC .95075 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000307519.4:p.Ile423Asn ENST00000305363.8:c.1268T>A 4:g.68496800T>A ITPKB_ENST00000272117 ENST00000272117.7 2841 6179 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV99684689 COSM8532039 97110328 c.977C>T p.P326L Substitution - Missense 38 1:226736482-226736482 - - NEUTRAL .01729 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000272117.3:p.Pro326Leu ENST00000272117.7:c.977C>T 1:g.226736482G>A SCN3A ENST00000283254.11 6003 10590 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105872781 COSM10012800 98527161 c.5525T>A p.V1842D Substitution - Missense 38 2:165090628-165090628 - - PATHOGENIC .99267 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000283254.7:p.Val1842Asp ENST00000283254.11:c.5525T>A 2:g.165090628A>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 88 2630342 2490726 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51769145 COSM3266559 174356454 c.256G>A p.V86M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 27756406 surgery-fixed primary 48 ENSP00000492462.1:p.Val86Met ENST00000638463.1:c.256G>A 7:g.55154137G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0005051-T01-IM5 2721455 2580276 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T TTN_ENST00000342992 ENST00000342992.10 100272 12403 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV59957361 COSM130006 106933207 c.184C>T p.R62C Substitution - Missense 38 2:178802249-178802249 - - PATHOGENIC .99021 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000343764.6:p.Arg62Cys ENST00000342992.10:c.184C>T 2:g.178802249G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2842046 2842046 2697595 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV104577028 COSM9413137 174399940 c.854T>A p.I285K Substitution - Missense 38 7:55160312-55160312 + - NEUTRAL .08768 Confirmed somatic variant 31924740 circulating tumour recurrent ENSP00000492462.1:p.Ile285Lys ENST00000638463.1:c.854T>A 7:g.55160312T>A HTR3E_ENST00000425359 ENST00000425359.6 1326 24005 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105899663 COSM10012911 124731268 c.463C>A p.P155T Substitution - Missense 38 3:184104905-184104905 + - PATHOGENIC .98714 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000401900.2:p.Pro155Thr ENST00000425359.6:c.463C>A 3:g.184104905C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 R074-R1 2813496 2669888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 41 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003705-T01-IM5 2720193 2579014 large_intestine appendix NS NS carcinoma adenocarcinoma NS NS n COSV51812036 COSM48318 174379219 c.1171G>A p.A391T Substitution - Missense het 38 7:55165346-55165346 + - NEUTRAL .27484 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Ala391Thr ENST00000638463.1:c.1171G>A 7:g.55165346G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 S001018 1027698 944674 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-14-2554-01 1338017 1248402 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 52 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 HCC-JP-457-T 2746985 2605688 liver NS NS NS other neoplasm NS NS y COSV51770509 COSM7191105 174354716 c.1252T>G p.C418G Substitution - Missense 38 7:55165427-55165427 + - PATHOGENIC .99836 Confirmed somatic variant 323 NS primary 77 ENSP00000492462.1:p.Cys418Gly ENST00000638463.1:c.1252T>G 7:g.55165427T>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 WGC003608 2785119 2645235 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS y COSV99286188 COSM7420903 174372344 c.952G>T p.V318F Substitution - Missense 38 7:55161570-55161570 + - .6767 Confirmed somatic variant 25526346 surgery fresh/frozen primary 54 ENSP00000492462.1:p.Val318Phe ENST00000638463.1:c.952G>T 7:g.55161570G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-28-5209-01 2120334 1994570 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51808387 COSM3412196 174337713 c.1175G>C p.G392A Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 329 NS NS 66 ENSP00000492462.1:p.Gly392Ala ENST00000638463.1:c.1175G>C 7:g.55165350G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GBM7-I1 2813443 2669835 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51772147 COSM375343 174337812 c.1316C>G p.S439C Substitution - Missense 38 7:55172997-55172997 + - PATHOGENIC .99586 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000492462.1:p.Ser439Cys ENST00000638463.1:c.1316C>G 7:g.55172997C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-CV-7252-01 2193523 2061801 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 627 NS NS 62 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0006054-T01-IM5 2722434 2581255 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T FAM78B_ENST00000354422 ENST00000354422.3 786 13495 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57975578 COSM4798871 107052598 c.157G>A p.A53T Substitution - Missense 38 1:166166092-166166092 - - PATHOGENIC .96596 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000346404.3:p.Ala53Thr ENST00000354422.3:c.157G>A 1:g.166166092C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0009239-T01-IM5 2725198 2584019 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51792469 COSM6967655 174343658 c.989T>A p.V330E Substitution - Missense het 38 7:55161607-55161607 + - PATHOGENIC .99007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Val330Glu ENST00000638463.1:c.989T>A 7:g.55161607T>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0001971-T01-IM3 2718279 2577100 central_nervous_system brain NS NS glioma astrocytoma NS NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0001248-T01-IM3 2716920 2575741 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51855488 COSM4166393 174335308 c.92C>T p.A31V Substitution - Missense het 38 7:55152627-55152627 + - PATHOGENIC .99229 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Ala31Val ENST00000638463.1:c.92C>T 7:g.55152627C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-32-1991-01 2120347 1994583 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 60 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0009711-T01-IM5 2725587 2584408 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 YUSCO 2013686 1896318 skin NS NS NS malignant_melanoma NS NS NS y COSV51778830 COSM1698691 174322993 c.580G>A p.E194K Substitution - Missense het 38 7:55156823-55156823 + - PATHOGENIC .99571 Confirmed somatic variant 22842228 NS NS ENSP00000492462.1:p.Glu194Lys ENST00000638463.1:c.580G>A 7:g.55156823G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 587220 1766747 1671067 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51792177 COSM1205050 174325727 c.661C>T p.R221C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 22895193 surgery fresh/frozen primary ENSP00000492462.1:p.Arg221Cys ENST00000638463.1:c.661C>T 7:g.55157734C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 SJHYPO052-D 2590140 2451270 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_leukaemia NS NS y COSV51792177 COSM1205050 174325727 c.661C>T p.R221C Substitution - Missense 38 7:55157734-55157734 + - PATHOGENIC .99556 Confirmed somatic variant 23334668 blood-bone marrow NS 16.3 ENSP00000492462.1:p.Arg221Cys ENST00000638463.1:c.661C>T 7:g.55157734C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0000154-T01-IM3 2714713 2573534 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51819471 COSM6909030 174342228 c.655A>C p.I219L Substitution - Missense het 38 7:55157728-55157728 + - PATHOGENIC .99224 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ile219Leu ENST00000638463.1:c.655A>C 7:g.55157728A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 CS1-C 2898363 2752647 endometrium NS NS NS carcinoma carcinosarcoma-malignant_mesodermal_mixed_tumour NS NS y COSV51806667 COSM6987130 174343458 c.1321G>A p.A441T Substitution - Missense 38 7:55173002-55173002 + - PATHOGENIC .99609 Confirmed somatic variant 33021035 surgery fresh/frozen NS 84 ENSP00000492462.1:p.Ala441Thr ENST00000638463.1:c.1321G>A 7:g.55173002G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 CRC177post 2730751 2589520 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51776247 COSM6110417 174336954 c.775G>A p.G259R Substitution - Missense 38 7:55160233-55160233 + - NEUTRAL .19805 Confirmed somatic variant 26416732 xenograft metastasis 59 ENSP00000492462.1:p.Gly259Arg ENST00000638463.1:c.775G>A 7:g.55160233G>A SNAPC4 ENST00000298532.2 4410 11137 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105880570 COSM10012767 99122019 c.1562C>T p.T521I Substitution - Missense 38 9:136383607-136383607 - - NEUTRAL .37557 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000298532.2:p.Thr521Ile ENST00000298532.2:c.1562C>T 9:g.136383607G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 T3174 2658322 2518481 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 174328588 c.962G>A p.R321Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 74.41 ENSP00000492462.1:p.Arg321Gln ENST00000638463.1:c.962G>A 7:g.55161580G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0011107-T01-IM5 2726736 2585557 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T OR10K1_ENST00000641460 ENST00000641460.1 942 14693 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV56872727 COSM5698964 173768057 c.346G>T p.A116S Substitution - Missense 38 1:158465907-158465907 + - .50134 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000493278.1:p.Ala116Ser ENST00000641460.1:c.346G>T 1:g.158465907G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-E1-A7YD-01 2386254 2249086 central_nervous_system brain NS NS glioma NS NS NS y COSV51785554 COSM21688 174319529 c.353G>T p.R118L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 545 NS primary 57 ENSP00000492462.1:p.Arg118Leu ENST00000638463.1:c.353G>T 7:g.55155911G>T OR56A1 ENST00000316650.5 957 14781 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105883756 COSM10012845 104794830 c.767T>G p.L256R Substitution - Missense 38 11:6026938-6026938 - - NEUTRAL .24245 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000321246.5:p.Leu256Arg ENST00000316650.5:c.767T>G 11:g.6026938A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 95504 1973048 1859292 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSV51812284 COSM1651737 174365491 c.203C>T p.T68M Substitution - Missense 38 7:55154084-55154084 + - PATHOGENIC .92031 Confirmed somatic variant 23680147 surgery - NOS primary ENSP00000492462.1:p.Thr68Met ENST00000638463.1:c.203C>T 7:g.55154084C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 PD7044a 1504255 1427133 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51826432 COSM4384121 174357456 c.952G>A p.V318I Substitution - Missense 38 7:55161570-55161570 + - PATHOGENIC .78109 Confirmed somatic variant 24030381 NS NS ENSP00000492462.1:p.Val318Ile ENST00000638463.1:c.952G>A 7:g.55161570G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2772383 2772383 2630573 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV99290341 COSM7347800 174369868 c.398G>A p.G133E Substitution - Missense 38 7:55156542-55156542 + - PATHOGENIC .99668 Confirmed somatic variant 29807833 circulating tumour NS ENSP00000492462.1:p.Gly133Glu ENST00000638463.1:c.398G>A 7:g.55156542G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1690841 1690841 1599108 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 174332720 c.856A>C p.S286R Substitution - Missense het 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 22270724 surgery - NOS recurrent 64 ENSP00000492462.1:p.Ser286Arg ENST00000638463.1:c.856A>C 7:g.55160314A>C ITPKB_ENST00000366784 ENST00000366784.1 1935 6179 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV99684689 COSM8532039 108989253 c.977C>T p.P326L Substitution - Missense 38 1:226736482-226736482 - - NEUTRAL .01729 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000355748.1:p.Pro326Leu ENST00000366784.1:c.977C>T 1:g.226736482G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 T1803 2658686 2518845 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51850996 COSM6652242 174335821 c.574G>A p.V192I Substitution - Missense 38 7:55156817-55156817 + - PATHOGENIC .99161 Confirmed somatic variant 27149842 NS NS 63 ENSP00000492462.1:p.Val192Ile ENST00000638463.1:c.574G>A 7:g.55156817G>A RASGRF1 ENST00000419573.7 3822 9875 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105938097 COSM10012910 122588801 c.850G>A p.D284N Substitution - Missense 38 15:79046774-79046774 - - PATHOGENIC .915 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000405963.3:p.Asp284Asn ENST00000419573.7:c.850G>A 15:g.79046774C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0001042-T01-IM3 2716511 2575332 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-OL-A97C-01 2386126 2248958 breast NS NS NS carcinoma NS NS NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 414 NS primary 67 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 SF268 1998472 1883544 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 23856246 cell-line primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0012402-T01-IM5 2727458 2586279 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51850996 COSM6652242 174335821 c.574G>A p.V192I Substitution - Missense het 38 7:55156817-55156817 + - PATHOGENIC .99161 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Val192Ile ENST00000638463.1:c.574G>A 7:g.55156817G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-MV-A51V-01 2193279 2061557 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51815409 COSM7143473 174335203 c.551A>G p.Q184R Substitution - Missense 38 7:55156794-55156794 + - NEUTRAL .3199 Confirmed somatic variant 413 NS NS 75 ENSP00000492462.1:p.Gln184Arg ENST00000638463.1:c.551A>G 7:g.55156794A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-A6S1-01 2263260 2130244 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS primary 53 ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0000918-T01-IM3 2716255 2575076 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51799159 COSM747427 174345260 c.1148C>T p.P383L Substitution - Missense het 38 7:55165323-55165323 + - PATHOGENIC .95834 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Pro383Leu ENST00000638463.1:c.1148C>T 7:g.55165323C>T SCN3A_ENST00000360093 ENST00000360093.7 6003 10590 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105872781 COSM10012800 107214771 c.5525T>A p.V1842D Substitution - Missense 38 2:165090628-165090628 - - PATHOGENIC .99267 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000353206.3:p.Val1842Asp ENST00000360093.7:c.5525T>A 2:g.165090628A>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003702-T02-IM5 2829639 2685454 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51831642 COSM1496684 174333100 c.370G>A p.E124K Substitution - Missense 38 7:55155928-55155928 + - PATHOGENIC .94538 Confirmed somatic variant 30205045 surgery-fixed metastasis 50 ENSP00000492462.1:p.Glu124Lys ENST00000638463.1:c.370G>A 7:g.55155928G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 5-VS034-T2 2869859 2724856 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51802355 COSM6941144 174320405 c.536C>T p.P179L Substitution - Missense 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 26950094 surgery - NOS NS 75 ENSP00000492462.1:p.Pro179Leu ENST00000638463.1:c.536C>T 7:g.55156779C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-B0-4822-01 2120426 1994662 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51848907 COSM3366976 174342683 c.358T>C p.C120R Substitution - Missense 38 7:55155916-55155916 + - PATHOGENIC .98755 Confirmed somatic variant 416 NS NS 78 ENSP00000492462.1:p.Cys120Arg ENST00000638463.1:c.358T>C 7:g.55155916T>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0000657-T02-IM5 2719370 2578191 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 174337713 c.1175G>C p.G392A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000492462.1:p.Gly392Ala ENST00000638463.1:c.1175G>C 7:g.55165350G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0008257-T01-IM5 2724396 2583217 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766389 COSM43067 174346864 c.256G>T p.V86L Substitution - Missense het 38 7:55154137-55154137 + - PATHOGENIC .98997 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Val86Leu ENST00000638463.1:c.256G>T 7:g.55154137G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-12-0670-01 2178104 2046402 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 174322412 c.169A>C p.T57P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 NS NS 60 ENSP00000492462.1:p.Thr57Pro ENST00000638463.1:c.169A>C 7:g.55154050A>C ZNF334_ENST00000625284 ENST00000625284.2 2040 15806 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV61619438 COSM1027463 168633228 c.1910G>A p.R637H Substitution - Missense 38 20:46501426-46501426 - - NEUTRAL .00039 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000485779.1:p.Arg637His ENST00000625284.2:c.1910G>A 20:g.46501426C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 EXTERN_MELA_20140514_008 2839310 2695076 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV104577177 COSM9365746 174393777 c.1378C>T p.L460F Substitution - Missense 38 7:55173059-55173059 + - PATHOGENIC .98429 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000492462.1:p.Leu460Phe ENST00000638463.1:c.1378C>T 7:g.55173059C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-12-0670 2108025 1985886 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 174322412 c.169A>C p.T57P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Thr57Pro ENST00000638463.1:c.169A>C 7:g.55154050A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-EB-A431-01 2121600 1995836 skin NS NS NS malignant_melanoma NS NS NS y COSV51820698 COSM3639725 174347460 c.62C>T p.S21F Substitution - Missense 38 7:55152597-55152597 + - NEUTRAL .18615 Confirmed somatic variant 540 NS NS 34 ENSP00000492462.1:p.Ser21Phe ENST00000638463.1:c.62C>T 7:g.55152597C>T CEACAM20 ENST00000614924.4 1791 24879 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105885448 COSM10012840 169907528 c.211T>C p.S71P Substitution - Missense 38 19:44524247-44524247 - - NEUTRAL .07541 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000481937.1:p.Ser71Pro ENST00000614924.4:c.211T>C 19:g.44524247A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GBM12 2144553 2013767 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 24285547 surgery fresh/frozen primary 64 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T PLAA ENST00000397292.7 2388 9043 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105935379 COSM10012842 118971375 c.955C>T p.H319Y Substitution - Missense 38 9:26923262-26923262 - - PATHOGENIC .95978 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000380460.3:p.His319Tyr ENST00000397292.7:c.955C>T 9:g.26923262G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 T3265 2658621 2518780 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51815655 COSM6652276 174399386 c.295G>A p.G99S Substitution - Missense 38 7:55155853-55155853 + - PATHOGENIC .97718 Confirmed somatic variant 27149842 NS NS 74.91 ENSP00000492462.1:p.Gly99Ser ENST00000638463.1:c.295G>A 7:g.55155853G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 APGI-AMP-2890 2866039 2721116 pancreas ampulla_of_Vater NS NS carcinoma ductal_carcinoma NS NS y COSV105111099 COSM9620623 174363956 c.43G>A p.G15R Substitution - Missense 38 7:55152578-55152578 + - NEUTRAL .36671 Confirmed somatic variant 26804919 surgery fresh/frozen NS ENSP00000492462.1:p.Gly15Arg ENST00000638463.1:c.43G>A 7:g.55152578G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003456-T01-IM5 2719933 2578754 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 174325029 c.136C>T p.R46C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Arg46Cys ENST00000638463.1:c.136C>T 7:g.55154017C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 T1154 2296082 2161685 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51814845 COSM4680396 174385263 c.1079C>T p.A360V Substitution - Missense 38 7:55163798-55163798 + - NEUTRAL .08918 Confirmed somatic variant 25344691 NS NS 68.33 ENSP00000492462.1:p.Ala360Val ENST00000638463.1:c.1079C>T 7:g.55163798C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 MSU3-c 2809980 2666642 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV99292326 COSM9176305 174349512 c.961C>T p.R321W Substitution - Missense 38 7:55161579-55161579 + - NEUTRAL .28879 Confirmed somatic variant 26336987 surgery fresh/frozen primary 51 ENSP00000492462.1:p.Arg321Trp ENST00000638463.1:c.961C>T 7:g.55161579C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51816377 COSM3412194 174319015 c.1168C>T p.P390S Substitution - Missense 38 7:55165343-55165343 + - PATHOGENIC .99531 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000492462.1:p.Pro390Ser ENST00000638463.1:c.1168C>T 7:g.55165343C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-A2-A4S3-01 2187874 2056152 breast NS NS NS carcinoma NS NS NS y COSV51810209 COSM3833026 174323488 c.323A>G p.D108G Substitution - Missense 38 7:55155881-55155881 + - PATHOGENIC .96368 Confirmed somatic variant 414 NS NS 59 ENSP00000492462.1:p.Asp108Gly ENST00000638463.1:c.323A>G 7:g.55155881A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 5-VS098-T1 2869935 2724932 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110457 COSM9807780 174349644 c.547C>T p.P183S Substitution - Missense 38 7:55156790-55156790 + - PATHOGENIC .99297 Confirmed somatic variant 26950094 surgery - NOS NS 84 ENSP00000492462.1:p.Pro183Ser ENST00000638463.1:c.547C>T 7:g.55156790C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-12-0656-01 2178172 2046470 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 174320891 c.248C>A p.A83D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 NS NS 48 ENSP00000492462.1:p.Ala83Asp ENST00000638463.1:c.248C>A 7:g.55154129C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-15-0742-01 1338018 1248403 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51827490 COSM39163 174340256 c.1289G>A p.C430Y Substitution - Missense 38 7:55171201-55171201 + - PATHOGENIC .98251 Confirmed somatic variant 329 surgery fresh/frozen NS 65 ENSP00000492462.1:p.Cys430Tyr ENST00000638463.1:c.1289G>A 7:g.55171201G>A CLCNKA_ENST00000375692 ENST00000375692.5 2061 2026 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV58890629 COSM1737785 113681087 c.1729A>G p.T577A Substitution - Missense 38 1:16031816-16031816 + - NEUTRAL .00395 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000364844.1:p.Thr577Ala ENST00000375692.5:c.1729A>G 1:g.16031816A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-AR-A0TV-01 1779493 1683492 breast NS NS NS carcinoma NS NS NS y COSV99293406 COSM7679798 174357551 c.959G>C p.C320S Substitution - Missense 38 7:55161577-55161577 + - PATHOGENIC .9951 Confirmed somatic variant 414 fresh/frozen - NOS primary 66 ENSP00000492462.1:p.Cys320Ser ENST00000638463.1:c.959G>C 7:g.55161577G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0016773-T01-IM6 2830871 2686686 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV104577017 COSM9359622 174339568 c.125G>A p.C42Y Substitution - Missense 38 7:55152660-55152660 + - PATHOGENIC .99504 Confirmed somatic variant 30205045 surgery-fixed primary 77 ENSP00000492462.1:p.Cys42Tyr ENST00000638463.1:c.125G>A 7:g.55152660G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836217 COSM7314292 174350606 c.796G>T p.A266S Substitution - Missense 38 7:55160254-55160254 + - PATHOGENIC .97432 Confirmed somatic variant 660 NS primary 46 ENSP00000492462.1:p.Ala266Ser ENST00000638463.1:c.796G>T 7:g.55160254G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 PD6883a 1504094 1426972 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia NS n COSV51850592 COSM4384117 174330036 c.136C>G p.R46G Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .93941 Confirmed somatic variant 24030381 NS NS ENSP00000492462.1:p.Arg46Gly ENST00000638463.1:c.136C>G 7:g.55154017C>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 S003577 1027697 944673 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779162 COSM21689 174318949 c.1169C>T p.P390L Substitution - Missense het 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000492462.1:p.Pro390Leu ENST00000638463.1:c.1169C>T 7:g.55165344C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0010864-T01-IM5 2726533 2585354 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51864573 COSM6977465 174328862 c.499C>T p.P167S Substitution - Missense het 38 7:55156643-55156643 + - PATHOGENIC .91736 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Pro167Ser ENST00000638463.1:c.499C>T 7:g.55156643C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 DUMC-18 2748715 2607418 central_nervous_system frontoparietal NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 29802247 surgery fresh/frozen NS 52 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 23 2699404 2558308 skin NS NS NS malignant_melanoma NS NS NS n COSV51774288 COSM6906389 174333294 c.638_639delinsTT p.A213V Substitution - Missense het 38 7:55157711-55157712 + - Confirmed somatic variant 29420467 surgery-fixed NS ENSP00000492462.1:p.Ala213Val ENST00000638463.1:c.638_639delinsTT 7:g.55157711_55157712delinsTT EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0011219-T01-IM5 2726835 2585656 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827895 COSM3412174 174323173 c.67A>T p.S23C Substitution - Missense het 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ser23Cys ENST00000638463.1:c.67A>T 7:g.55152602A>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TARGET-30-PALUDH-01A-01W 2195523 2063801 autonomic_ganglia NS NS NS neuroblastoma NS NS NS y COSV51767481 COSM1284692 174330758 c.1304C>A p.P435H Substitution - Missense 38 7:55172985-55172985 + - PATHOGENIC .97992 Confirmed somatic variant 584 NS NS ENSP00000492462.1:p.Pro435His ENST00000638463.1:c.1304C>A 7:g.55172985C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003456-T01-IM5 2719933 2578754 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-QH-A6XC-01 2263268 2130252 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS primary 48 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0008246-T02-IM5 2724392 2583213 skin NS NS NS malignant_melanoma NS NS NS n COSV51776967 COSM6963220 174335149 c.1312C>T p.P438S Substitution - Missense het 38 7:55172993-55172993 + - PATHOGENIC .96242 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Pro438Ser ENST00000638463.1:c.1312C>T 7:g.55172993C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0006846-T01-IM5 2723226 2582047 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-GN-A269-01 2121799 1996035 skin NS NS NS malignant_melanoma NS NS NS y COSV51823432 COSM3639727 174334863 c.83A>G p.N28S Substitution - Missense 38 7:55152618-55152618 + - PATHOGENIC .95999 Confirmed somatic variant 540 NS NS 70 ENSP00000492462.1:p.Asn28Ser ENST00000638463.1:c.83A>G 7:g.55152618A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0006846-T01-IM5 2723226 2582047 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51781750 COSM6954369 174344595 c.336G>A p.M112I Substitution - Missense het 38 7:55155894-55155894 + - PATHOGENIC .91367 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Met112Ile ENST00000638463.1:c.336G>A 7:g.55155894G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-CN-4742-01 2193489 2061767 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825459 COSM122789 174330852 c.805A>G p.I269V Substitution - Missense 38 7:55160263-55160263 + - PATHOGENIC .89583 Confirmed somatic variant 627 NS NS 48 ENSP00000492462.1:p.Ile269Val ENST00000638463.1:c.805A>G 7:g.55160263A>G EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-DU-A5TY-01 2194202 2062480 central_nervous_system brain NS NS glioma NS NS NS y COSV51765897 COSM3929120 174375353 c.343G>T p.D115Y Substitution - Missense 38 7:55155901-55155901 + - PATHOGENIC .95198 Confirmed somatic variant 545 NS NS 46 ENSP00000492462.1:p.Asp115Tyr ENST00000638463.1:c.343G>T 7:g.55155901G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 PD11341a 1749312 1654153 breast NS NS NS carcinoma ductal_carcinoma mucinous NS y COSV51807785 COSM5782738 174371099 c.1372A>T p.I458F Substitution - Missense 38 7:55173053-55173053 + - PATHOGENIC .88741 Confirmed somatic variant 652 NS NS ENSP00000492462.1:p.Ile458Phe ENST00000638463.1:c.1372A>T 7:g.55173053A>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-76-4927-01 2120379 1994615 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 58 ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-FG-A87Q-01 2339613 2204596 central_nervous_system brain NS NS glioma NS NS NS y COSV99289246 COSM8268187 174322063 c.170C>T p.T57I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 545 NS primary 61 ENSP00000492462.1:p.Thr57Ile ENST00000638463.1:c.170C>T 7:g.55154051C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GBM_IV-19 2354288 2218446 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0005889-T01-IM5 2722273 2581094 testis NS NS NS germ_cell_tumour seminoma NS NS n COSV51857848 COSM6946731 174323880 c.836G>A p.G279D Substitution - Missense het 38 7:55160294-55160294 + - NEUTRAL .16911 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000492462.1:p.Gly279Asp ENST00000638463.1:c.836G>A 7:g.55160294G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 T3174 2296192 2161795 large_intestine colon transverse NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 174328588 c.962G>A p.R321Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 25344691 NS NS 74.41 ENSP00000492462.1:p.Arg321Gln ENST00000638463.1:c.962G>A 7:g.55161580G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-E1-A7YQ-01 2386259 2249091 central_nervous_system brain NS NS glioma NS NS NS y COSV99286607 COSM8256230 174397618 c.1376G>A p.G459D Substitution - Missense 38 7:55173057-55173057 + - PATHOGENIC .9747 Confirmed somatic variant 545 NS primary 58 ENSP00000492462.1:p.Gly459Asp ENST00000638463.1:c.1376G>A 7:g.55173057G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51808387 COSM3412196 174337713 c.1175G>C p.G392A Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000492462.1:p.Gly392Ala ENST00000638463.1:c.1175G>C 7:g.55165350G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0211-01 1910206 1798497 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 174322412 c.169A>C p.T57P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 fresh/frozen - NOS primary 48 ENSP00000492462.1:p.Thr57Pro ENST00000638463.1:c.169A>C 7:g.55154050A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 SJHGG023_D 2307355 2172559 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 24705251 surgery - NOS NS 4 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 174321914 c.292C>T p.H98Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000492462.1:p.His98Tyr ENST00000638463.1:c.292C>T 7:g.55155850C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-DU-A5TY-01 2194202 2062480 central_nervous_system brain NS NS glioma NS NS NS y COSV51765881 COSM3929118 174375341 c.331G>A p.E111K Substitution - Missense 38 7:55155889-55155889 + - PATHOGENIC .99356 Confirmed somatic variant 545 NS NS 46 ENSP00000492462.1:p.Glu111Lys ENST00000638463.1:c.331G>A 7:g.55155889G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836185 COSM4884832 174350588 c.121G>T p.D41Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 660 NS primary 46 ENSP00000492462.1:p.Asp41Tyr ENST00000638463.1:c.121G>T 7:g.55152656G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 zcc203 2873641 2728634 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS y COSV99297135 COSM9212199 174339656 c.247G>T p.A83S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 33020650 surgery fresh/frozen NS ENSP00000492462.1:p.Ala83Ser ENST00000638463.1:c.247G>T 7:g.55154128G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2812807 2812807 2669221 liver NS NS NS other adenoma NS NS n COSV51845994 COSM5530405 174318236 c.1015G>A p.E339K Substitution - Missense 38 7:55163734-55163734 + - PATHOGENIC .9787 Confirmed somatic variant 31189995 surgery-fixed NS 9 ENSP00000492462.1:p.Glu339Lys ENST00000638463.1:c.1015G>A 7:g.55163734G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 YUOTHO 2439352 2302193 skin NS NS NS malignant_melanoma NS NS NS y COSV51848994 COSM5407724 174334107 c.1083G>A p.M361I Substitution - Missense het 38 7:55163802-55163802 + - PATHOGENIC .89204 Confirmed somatic variant 26214590 fresh/frozen - NOS primary 87 ENSP00000492462.1:p.Met361Ile ENST00000638463.1:c.1083G>A 7:g.55163802G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 ILMN12 2816772 2673123 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV104369087 COSM9238851 174351474 c.1219G>A p.A407T Substitution - Missense 38 7:55165394-55165394 + - PATHOGENIC .87498 Confirmed somatic variant 29937994 surgery fresh/frozen NS 45 ENSP00000492462.1:p.Ala407Thr ENST00000638463.1:c.1219G>A 7:g.55165394G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836251 COSM6348839 174350628 c.909G>T p.L303F Substitution - Missense 38 7:55161527-55161527 + - PATHOGENIC .8964 Confirmed somatic variant 660 NS primary 46 ENSP00000492462.1:p.Leu303Phe ENST00000638463.1:c.909G>T 7:g.55161527G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2014_Lung_sq_70_T 2744941 2603644 lung NS NS NS carcinoma NS NS NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 583 NS primary 48 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0006952-T01-IM5 2723330 2582151 skin NS NS NS malignant_melanoma NS NS NS n COSV51774288 COSM6906389 174333294 c.638_639delinsTT p.A213V Substitution - Missense het 38 7:55157711-55157712 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala213Val ENST00000638463.1:c.638_639delinsTT 7:g.55157711_55157712delinsTT EGFR_ENST00000638463 ENST00000638463.1 1392 3236 R074-I1 2813495 2669887 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99297135 COSM9212199 174339656 c.247G>T p.A83S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 28263318 surgery fresh/frozen NS 41 ENSP00000492462.1:p.Ala83Ser ENST00000638463.1:c.247G>T 7:g.55154128G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 T1244 2658449 2518608 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777833 COSM4680394 174328588 c.962G>A p.R321Q Substitution - Missense 38 7:55161580-55161580 + - NEUTRAL .07795 Confirmed somatic variant 27149842 NS NS 62.75 ENSP00000492462.1:p.Arg321Gln ENST00000638463.1:c.962G>A 7:g.55161580G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-DU-5852-01 2194247 2062525 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 174325029 c.136C>T p.R46C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS NS 61 ENSP00000492462.1:p.Arg46Cys ENST00000638463.1:c.136C>T 7:g.55154017C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-E1-A7YJ-01 2457421 2320258 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 174325029 c.136C>T p.R46C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS primary 55 ENSP00000492462.1:p.Arg46Cys ENST00000638463.1:c.136C>T 7:g.55154017C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P121 2072581 1951936 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51785554 COSM21688 174319529 c.353G>T p.R118L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 57.59 ENSP00000492462.1:p.Arg118Leu ENST00000638463.1:c.353G>T 7:g.55155911G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0004666-T01-IM5 2721066 2579887 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51811159 COSM236671 174332720 c.856A>C p.S286R Substitution - Missense het 38 7:55160314-55160314 + - NEUTRAL .44425 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000492462.1:p.Ser286Arg ENST00000638463.1:c.856A>C 7:g.55160314A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-BR-A4QL-01 2197931 2066209 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51771306 COSM1318972 174335686 c.1295C>T p.T432M Substitution - Missense 38 7:55171207-55171207 + - NEUTRAL .03249 Confirmed somatic variant 541 NS NS 75 ENSP00000492462.1:p.Thr432Met ENST00000638463.1:c.1295C>T 7:g.55171207C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-26-5139-01 2120327 1994563 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51840469 COSM2157152 174371227 c.1265G>T p.C422F Substitution - Missense 38 7:55171177-55171177 + - PATHOGENIC .98352 Confirmed somatic variant 329 NS NS 65 ENSP00000492462.1:p.Cys422Phe ENST00000638463.1:c.1265G>T 7:g.55171177G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0009449-T01-IM5 2725376 2584197 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-CD-A4MG-01 2198123 2066401 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51852047 COSM3881818 174337817 c.671C>T p.T224I Substitution - Missense 38 7:55157744-55157744 + - PATHOGENIC .99429 Confirmed somatic variant 541 NS NS 76 ENSP00000492462.1:p.Thr224Ile ENST00000638463.1:c.671C>T 7:g.55157744C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0000316-T01-IM3 2715020 2573841 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792237 COSM6842523 174330879 c.211_212delinsGA p.M71E Substitution - Missense het 38 7:55154092-55154093 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Met71Glu ENST00000638463.1:c.211_212delinsGA 7:g.55154092_55154093delinsGA EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-HT-A5RC-01 2194260 2062538 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 70 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-76-4931-01 2120382 1994618 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 329 NS NS 70 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-DU-7013-01 2194399 2062677 central_nervous_system brain NS NS glioma NS NS NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 545 NS NS 59 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 NB-1204 1898491 1787175 autonomic_ganglia NS NS NS neuroblastoma NS NS NS y COSV51767481 COSM1284692 174330758 c.1304C>A p.P435H Substitution - Missense 38 7:55172985-55172985 + - PATHOGENIC .97992 Confirmed somatic variant 23334666 NS NS ENSP00000492462.1:p.Pro435His ENST00000638463.1:c.1304C>A 7:g.55172985C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-12-0616 2108021 1985882 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 BC85-ctDNA 2668219 2527792 breast NS NS NS carcinoma NS NS NS y COSV51834499 COSM6845063 174319637 c.346G>A p.G116S Substitution - Missense het 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 27535334 circulating tumour metastasis ENSP00000492462.1:p.Gly116Ser ENST00000638463.1:c.346G>A 7:g.55155904G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-TQ-A7RP-01 2457441 2320278 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 174325029 c.136C>T p.R46C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS primary 66 ENSP00000492462.1:p.Arg46Cys ENST00000638463.1:c.136C>T 7:g.55154017C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0011293-T01-IM5 2726897 2585718 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51862653 COSM6980033 174318274 c.1182G>T p.M394I Substitution - Missense het 38 7:55165357-55165357 + - PATHOGENIC .94832 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Met394Ile ENST00000638463.1:c.1182G>T 7:g.55165357G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 CH-LA8 2211434 2079637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51855488 COSM4166393 174335308 c.92C>T p.A31V Substitution - Missense 38 7:55152627-55152627 + - PATHOGENIC .99229 Confirmed somatic variant 24449147 surgery fresh/frozen NS 67 ENSP00000492462.1:p.Ala31Val ENST00000638463.1:c.92C>T 7:g.55152627C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-TM-A7C3-01 2262979 2129963 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 43 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003850-T01-IM5 2720342 2579163 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-76-4926-01 2120378 1994614 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 68 ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 EOPC-126_tumor_01 2633717 2494113 prostate NS NS NS carcinoma NS NS NS y COSV51793336 COSM6214981 174356977 c.1045T>C p.C349R Substitution - Missense 38 7:55163764-55163764 + - PATHOGENIC .99407 Confirmed somatic variant 534 NS primary 47 ENSP00000492462.1:p.Cys349Arg ENST00000638463.1:c.1045T>C 7:g.55163764T>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0010107-T01-IM5 2725918 2584739 genital_tract extragonadal soft_tissue NS germ_cell_tumour yolk_sac_tumour NS NS n COSV51834570 COSM6972645 174330651 c.1237C>A p.L413M Substitution - Missense het 38 7:55165412-55165412 + - PATHOGENIC .9982 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Leu413Met ENST00000638463.1:c.1237C>A 7:g.55165412C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0000370-T01-IM3 2715141 2573962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51849071 COSM6910043 174384018 c.213_214delinsTT p.M71_D72delinsIY Substitution - Missense het 38 7:55154094-55154095 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Met71_Asp72delinsIleTyr ENST00000638463.1:c.213_214delinsTT 7:g.55154094_55154095delinsTT EGFR_ENST00000638463 ENST00000638463.1 1392 3236 RS40M 2653649 2513771 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51770369 COSM3721608 174318068 c.944G>A p.R315K Substitution - Missense 38 7:55161562-55161562 + - NEUTRAL .0463 Confirmed somatic variant 26647728 NS metastasis 41.32 ENSP00000492462.1:p.Arg315Lys ENST00000638463.1:c.944G>A 7:g.55161562G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 S001102 1027688 944664 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 174322412 c.169A>C p.T57P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000492462.1:p.Thr57Pro ENST00000638463.1:c.169A>C 7:g.55154050A>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0013010-T01-IM5 2803821 2660571 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51866279 COSM6926300 174322028 c.47G>A p.R16H Substitution - Missense het 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 29316426 surgery-fixed primary 64 ENSP00000492462.1:p.Arg16His ENST00000638463.1:c.47G>A 7:g.55152582G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-AA-3811-01 1651034 1565821 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51779162 COSM21689 174318949 c.1169C>T p.P390L Substitution - Missense 38 7:55165344-55165344 + - PATHOGENIC .99531 Confirmed somatic variant 376 NS NS 84 ENSP00000492462.1:p.Pro390Leu ENST00000638463.1:c.1169C>T 7:g.55165344C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-IQ-7630-01 2193638 2061916 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51792433 COSM6966446 174352434 c.1144G>A p.G382S Substitution - Missense 38 7:55165319-55165319 + - PATHOGENIC .99683 Confirmed somatic variant 627 NS NS 49 ENSP00000492462.1:p.Gly382Ser ENST00000638463.1:c.1144G>A 7:g.55165319G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 R074-I1 2813495 2669887 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 41 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-AA-A00N-01 1651102 1565889 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51852585 COSM274945 174332231 c.308G>A p.R103Q Substitution - Missense 38 7:55155866-55155866 + - PATHOGENIC .98601 Confirmed somatic variant 22810696 376 NS NS 75 ENSP00000492462.1:p.Arg103Gln ENST00000638463.1:c.308G>A 7:g.55155866G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0005303-T01-IM5 2721704 2580525 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GBM9-I2 2813459 2669851 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51769031 COSM21690 174317610 c.1175G>T p.G392V Substitution - Missense 38 7:55165350-55165350 + - PATHOGENIC .99568 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000492462.1:p.Gly392Val ENST00000638463.1:c.1175G>T 7:g.55165350G>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-AA-3811-01 1651034 1565821 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 376 NS NS 84 ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0154 2107952 1985813 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 23917401 NS NS ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 2696711 2696711 2555615 oesophagus upper_third NS NS other metaplasia epidermoid NS n COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28731047 surgery-fixed primary 62 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-KT-A7W1-01 2262770 2129754 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 45 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 zcc203 2873641 2728634 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 33020650 surgery fresh/frozen NS ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 17218 1423801 1333829 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51785911 COSM48912 174387645 c.733_734delinsTT p.R245F Substitution - Missense het 38 7:55160191-55160192 + - Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000492462.1:p.Arg245Phe ENST00000638463.1:c.733_734delinsTT 7:g.55160191_55160192delinsTT EGFR_ENST00000638463 ENST00000638463.1 1392 3236 5-NB016-T1 2869816 2724813 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV51776967 COSM6963220 174335149 c.1312C>T p.P438S Substitution - Missense 38 7:55172993-55172993 + - PATHOGENIC .96242 Confirmed somatic variant 26950094 surgery fresh/frozen NS 74 ENSP00000492462.1:p.Pro438Ser ENST00000638463.1:c.1312C>T 7:g.55172993C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 PD42098a 2894843 2749331 skin trunk NS NS malignant_melanoma nodular NS NS y COSV51776967 COSM6963220 174335149 c.1312C>T p.P438S Substitution - Missense 38 7:55172993-55172993 + - PATHOGENIC .96242 Confirmed somatic variant 33024263 surgery-fixed metastasis 42 ENSP00000492462.1:p.Pro438Ser ENST00000638463.1:c.1312C>T 7:g.55172993C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-26-5139-01 2120327 1994563 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51856614 COSM3412172 174371214 c.50G>A p.C17Y Substitution - Missense 38 7:55152585-55152585 + - PATHOGENIC .99676 Confirmed somatic variant 329 NS NS 65 ENSP00000492462.1:p.Cys17Tyr ENST00000638463.1:c.50G>A 7:g.55152585G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0005852-T02-IM5 2722238 2581059 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GBM9-I2 2813459 2669851 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0006876-T01-IM5 2723256 2582077 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0000686-T01-IM3 2715784 2574605 skin NS NS NS malignant_melanoma NS NS NS n COSV51781503 COSM5608352 174343339 c.1291C>T p.P431S Substitution - Missense het 38 7:55171203-55171203 + - NEUTRAL .1586 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000492462.1:p.Pro431Ser ENST00000638463.1:c.1291C>T 7:g.55171203C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0011503-T01-IM5 2727075 2585896 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51808387 COSM3412196 174337713 c.1175G>C p.G392A Substitution - Missense het 38 7:55165350-55165350 + - PATHOGENIC .9959 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Gly392Ala ENST00000638463.1:c.1175G>C 7:g.55165350G>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003068-T01-IM5 2719577 2578398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51843270 COSM6926023 174344899 c.470C>A p.T157N Substitution - Missense het 38 7:55156614-55156614 + - PATHOGENIC .99429 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Thr157Asn ENST00000638463.1:c.470C>A 7:g.55156614C>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 1040346 1040346 956923 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_II NS NS n COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 P-0003170-T01-IM5 2719663 2578484 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51841905 COSM6926730 174321209 c.313T>C p.C105R Substitution - Missense het 38 7:55155871-55155871 + - PATHOGENIC .98694 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000492462.1:p.Cys105Arg ENST00000638463.1:c.313T>C 7:g.55155871T>C EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-A8-A094-01 1779383 1683382 breast NS NS NS carcinoma NS NS NS y COSV51768800 COSM6499385 174342526 c.226G>A p.E76K Substitution - Missense 38 7:55154107-55154107 + - PATHOGENIC .81806 Confirmed somatic variant 414 fresh/frozen - NOS primary 75 ENSP00000492462.1:p.Glu76Lys ENST00000638463.1:c.226G>A 7:g.55154107G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-06-0878-01 1337866 1248251 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 174317770 c.247G>A p.A83T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 74 ENSP00000492462.1:p.Ala83Thr ENST00000638463.1:c.247G>A 7:g.55154128G>A EGFR_ENST00000638463 ENST00000638463.1 1392 3236 TCGA-4W-AA9T-01 2339571 2204554 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 174321461 c.248C>T p.A83V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS primary 54 ENSP00000492462.1:p.Ala83Val ENST00000638463.1:c.248C>T 7:g.55154129C>T EGFR_ENST00000638463 ENST00000638463.1 1392 3236 GB052T 2634017 2494413 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 174318473 c.46C>T p.R16C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 672 NS primary ENSP00000492462.1:p.Arg16Cys ENST00000638463.1:c.46C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2840810 2840810 2696370 prostate NS NS NS carcinoma NS NS NS n COSV104577207 COSM9493802 124971657 c.686G>A p.S229N Substitution - Missense 38 7:55152603-55152603 + - PATHOGENIC .9474 Variant of unknown origin 31874108 surgery-fixed metastasis ENSP00000413843.2:p.Ser229Asn ENST00000420316.6:c.686G>A 7:g.55152603G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 5-GE067-T1 2869773 2724770 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51802062 COSM6008937 124951524 c.659C>T p.S220F Substitution - Missense 38 7:55152576-55152576 + - PATHOGENIC .98424 Variant of unknown origin 26950094 surgery - NOS NS ENSP00000413843.2:p.Ser220Phe ENST00000420316.6:c.659C>T 7:g.55152576C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 1194724 1194724 1106619 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849762 COSM29340 124971008 c.818C>A p.T273N Substitution - Missense 38 7:55154081-55154081 + - PATHOGENIC .90357 Variant of unknown origin 19284481 surgery fresh/frozen primary ENSP00000413843.2:p.Thr273Asn ENST00000420316.6:c.818C>A 7:g.55154081C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0000030-T01-IM3 2714482 2573303 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51789972 COSM6985979 124954209 c.903_906delinsACAC p.T302H Substitution - Missense het 38 7:55155843-55155846 + - Variant of unknown origin 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Thr302His ENST00000420316.6:c.903_906delinsACAC 7:g.55155843_55155846delinsACAC EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-24-1850-01 1731201 1637167 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51792742 COSM1330578 124970709 c.783G>T p.K261N Substitution - Missense het 38 7:55154046-55154046 + - PATHOGENIC .96256 Variant of unknown origin 331 NS primary 72 ENSP00000413843.2:p.Lys261Asn ENST00000420316.6:c.783G>T 7:g.55154046G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 LC20 2439238 2302079 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51781350 COSM5369838 124956568 c.407C>G p.P136R Substitution - Missense 38 7:55143471-55143471 + - PATHOGENIC .90708 Variant of unknown origin 26164066 surgery-fixed metastasis ENSP00000413843.2:p.Pro136Arg ENST00000420316.6:c.407C>G 7:g.55143471C>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 UCHRP3 2682242 2541515 large_intestine NS NS NS other ulcerative_colitis dysplasia NS n COSV51844380 COSM6854567 124955712 c.856A>G p.S286G Substitution - Missense 38 7:55154119-55154119 + - PATHOGENIC .99273 Variant of unknown origin 28524162 surgery fresh/frozen NS 54 ENSP00000413843.2:p.Ser286Gly ENST00000420316.6:c.856A>G 7:g.55154119A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 SUPT1 1760532 1665135 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51819830 COSM327147 124952321 c.752G>A p.C251Y Substitution - Missense 38 7:55154015-55154015 + - PATHOGENIC .98182 Variant of unknown origin 22675565 cell-line NS ENSP00000413843.2:p.Cys251Tyr ENST00000420316.6:c.752G>A 7:g.55154015G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-55-7570-01 1914018 1802300 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51813309 COSM6178064 124969133 c.898G>A p.V300M Substitution - Missense 38 7:55155838-55155838 + - PATHOGENIC .97875 Variant of unknown origin 417 fresh/frozen - NOS primary 60 ENSP00000413843.2:p.Val300Met ENST00000420316.6:c.898G>A 7:g.55155838G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2732915 2732915 2591668 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827181 COSM7002280 124964645 c.574C>G p.P192A Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .86378 Variant of unknown origin 28855349 surgery - NOS recurrent 58 ENSP00000413843.2:p.Pro192Ala ENST00000420316.6:c.574C>G 7:g.55151308C>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-08-0349-01 1910225 1798516 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51830791 COSM43068 124970837 c.977G>A p.C326Y Substitution - Missense het 38 7:55155917-55155917 + - PATHOGENIC .99356 Variant of unknown origin 329 fresh/frozen - NOS primary 46 ENSP00000413843.2:p.Cys326Tyr ENST00000420316.6:c.977G>A 7:g.55155917G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 LUAD_E01166 1765174 1669494 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51795467 COSM390866 124954479 c.709_710delinsTA p.A237Y Substitution - Missense 38 7:55152626-55152627 + - Variant of unknown origin 22980975 surgery - NOS primary ENSP00000413843.2:p.Ala237Tyr ENST00000420316.6:c.709_710delinsTA 7:g.55152626_55152627delinsTA EGFR_ENST00000420316 ENST00000420316.6 1218 3236 5-GE049-T1 2869762 2724759 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110412 COSM9799019 124971631 c.583C>T p.P195S Substitution - Missense 38 7:55151317-55151317 + - NEUTRAL .41768 Variant of unknown origin 26950094 surgery - NOS NS 80 ENSP00000413843.2:p.Pro195Ser ENST00000420316.6:c.583C>T 7:g.55151317C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2841222 2841222 2696782 prostate NS NS NS carcinoma NS NS NS n COSV104577073 COSM9497234 124970058 c.434A>G p.H145R Substitution - Missense 38 7:55146615-55146615 + - NEUTRAL .16662 Variant of unknown origin 31874108 surgery-fixed primary ENSP00000413843.2:p.His145Arg ENST00000420316.6:c.434A>G 7:g.55146615A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 AC-V16-Tumor-SM-9J46H 2584492 2445656 large_intestine anus NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51811313 COSM6008958 124948719 c.745C>G p.L249V Substitution - Missense 38 7:55152662-55152662 + - PATHOGENIC .95619 Variant of unknown origin 27852700 surgery-fixed recurrent ENSP00000413843.2:p.Leu249Val ENST00000420316.6:c.745C>G 7:g.55152662C>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2626134 2626134 2486546 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51791433 COSM6191492 124968712 c.887_888delinsTT p.P296L Substitution - Missense 38 7:55154150-55154151 + - Variant of unknown origin 26645239 surgery-fixed NS ENSP00000413843.2:p.Pro296Leu ENST00000420316.6:c.887_888delinsTT 7:g.55154150_55154151delinsTT EGFR_ENST00000420316 ENST00000420316.6 1218 3236 VOA1947 2897843 2752142 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105864361 COSM9970409 124966450 c.970C>T p.R324C Substitution - Missense 38 7:55155910-55155910 + - PATHOGENIC .91299 Variant of unknown origin 31477716 surgery-fixed metastasis 69 ENSP00000413843.2:p.Arg324Cys ENST00000420316.6:c.970C>T 7:g.55155910C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-08-0246-01 1910219 1798510 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51792876 COSM43066 124949866 c.767A>C p.D256A Substitution - Missense hom 38 7:55154030-55154030 + - PATHOGENIC .98125 Variant of unknown origin 329 fresh/frozen - NOS primary 57 ENSP00000413843.2:p.Asp256Ala ENST00000420316.6:c.767A>C 7:g.55154030A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-78-7147-01 1914054 1802336 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51797369 COSM6178060 124965804 c.1159C>A p.L387M Substitution - Missense 38 7:55156784-55156784 + - PATHOGENIC .85999 Variant of unknown origin 417 fresh/frozen - NOS primary 67 ENSP00000413843.2:p.Leu387Met ENST00000420316.6:c.1159C>A 7:g.55156784C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 AMO1 2809758 2666428 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasmacytoma NS NS y COSV51777457 COSM1236015 124956807 c.627A>C p.K209N Substitution - Missense het 38 7:55151361-55151361 + - NEUTRAL .14933 Variant of unknown origin 30545397 cell-line NS ENSP00000413843.2:p.Lys209Asn ENST00000420316.6:c.627A>C 7:g.55151361A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 NAN8 2809783 2666453 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV99289304 COSM9153919 124957708 c.670C>T p.R224C Substitution - Missense het 38 7:55152587-55152587 + - PATHOGENIC .90413 Variant of unknown origin 30545397 cell-line primary ENSP00000413843.2:p.Arg224Cys ENST00000420316.6:c.670C>T 7:g.55152587C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 DM16 2466857 2329688 skin head_neck NS NS malignant_melanoma desmoplastic NS NS n COSV51842833 COSM5608338 124964491 c.794C>T p.P265L Substitution - Missense 38 7:55154057-55154057 + - PATHOGENIC .98876 Variant of unknown origin 26343386 surgery-fixed NS 80 ENSP00000413843.2:p.Pro265Leu ENST00000420316.6:c.794C>T 7:g.55154057C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 WSU-HN30 2296299 2161902 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51845363 COSM4600429 124950032 c.316A>T p.I106F Substitution - Missense 38 7:55143380-55143380 + - PATHOGENIC .97255 Variant of unknown origin 25275298 cell-line NS ENSP00000413843.2:p.Ile106Phe ENST00000420316.6:c.316A>T 7:g.55143380A>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 NPC0001PT00226T00226 2857365 2712665 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 124958424 c.1162G>A p.D388N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000413843.2:p.Asp388Asn ENST00000420316.6:c.1162G>A 7:g.55156787G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 OV207 1716842 1624327 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51806026 COSM252488 124961177 c.493C>T p.R165W Substitution - Missense 38 7:55146674-55146674 + - NEUTRAL .14815 Variant of unknown origin 22102435 surgery fresh/frozen NS ENSP00000413843.2:p.Arg165Trp ENST00000420316.6:c.493C>T 7:g.55146674C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 H1793 2776325 2634461 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51866889 COSM3266567 124952308 c.932G>T p.C311F Substitution - Missense 38 7:55155872-55155872 + - PATHOGENIC .99418 Variant of unknown origin 29681454 NS NS 52 ENSP00000413843.2:p.Cys311Phe ENST00000420316.6:c.932G>T 7:g.55155872G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 VOA1720 2897846 2752145 ovary NS NS NS carcinoma mucinous_carcinoma NS NS n COSV105864482 COSM9969894 124967448 c.494G>C p.R165P Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .25613 Variant of unknown origin 31477716 surgery-fixed NS 73 ENSP00000413843.2:p.Arg165Pro ENST00000420316.6:c.494G>C 7:g.55146675G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-95-7947-01 1914103 1802385 lung right_upper_lobe NS NS carcinoma adenocarcinoma NS NS y COSV51819886 COSM6178068 124951253 c.271A>G p.I91V Substitution - Missense 38 7:55143335-55143335 + - PATHOGENIC .98845 Variant of unknown origin 417 fresh/frozen - NOS primary 67 ENSP00000413843.2:p.Ile91Val ENST00000420316.6:c.271A>G 7:g.55143335A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 UVDUD0 2762706 2620965 thyroid NS NS NS carcinoma anaplastic_carcinoma NS NS n COSV51767906 COSM7340119 124968094 c.433C>A p.H145N Substitution - Missense 38 7:55146614-55146614 + - NEUTRAL .01483 Variant of unknown origin 29615459 NS primary 63 ENSP00000413843.2:p.His145Asn ENST00000420316.6:c.433C>A 7:g.55146614C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105111181 COSM9542450 124958405 c.61G>A p.A21T Substitution - Missense 38 7:55019338-55019338 + - NEUTRAL .06121 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000413843.2:p.Ala21Thr ENST00000420316.6:c.61G>A 7:g.55019338G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2732914 2732914 2591667 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827181 COSM7002280 124964645 c.574C>G p.P192A Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .86378 Variant of unknown origin 28855349 surgery - NOS primary 58 ENSP00000413843.2:p.Pro192Ala ENST00000420316.6:c.574C>G 7:g.55151308C>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 NPC0001PT00349T00349 2857323 2712623 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 124958424 c.1162G>A p.D388N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000413843.2:p.Asp388Asn ENST00000420316.6:c.1162G>A 7:g.55156787G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 BL-18-K10011 2905035 2759291 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV105864163 COSM10000367 124961198 c.407C>A p.P136H Substitution - Missense 38 7:55143471-55143471 + - PATHOGENIC .91703 Variant of unknown origin 32321774 surgery-fixed primary ENSP00000413843.2:p.Pro136His ENST00000420316.6:c.407C>A 7:g.55143471C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-AP-A059-01 1783335 1687334 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51841162 COSM1090865 124949737 c.594C>A p.S198R Substitution - Missense het 38 7:55151328-55151328 + - PATHOGENIC .8706 Variant of unknown origin 419 fresh/frozen - NOS primary 69 ENSP00000413843.2:p.Ser198Arg ENST00000420316.6:c.594C>A 7:g.55151328C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 UM-SCC-17B 2296307 2161910 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51825836 COSM4599146 124957540 c.345T>A p.N115K Substitution - Missense 38 7:55143409-55143409 + - NEUTRAL .2671 Variant of unknown origin 25275298 cell-line NS 47 ENSP00000413843.2:p.Asn115Lys ENST00000420316.6:c.345T>A 7:g.55143409T>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 AMO1 1889514 1778954 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm plasma_cell_myeloma NS NS y COSV51777457 COSM1236015 124956807 c.627A>C p.K209N Substitution - Missense 38 7:55151361-55151361 + - NEUTRAL .14933 Variant of unknown origin 23396385 cell-line NS ENSP00000413843.2:p.Lys209Asn ENST00000420316.6:c.627A>C 7:g.55151361A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 KARPAS45 1760525 1665128 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm acute_lymphoblastic_T_cell_leukaemia NS NS n COSV51767338 COSM327145 124951948 c.227T>C p.L76P Substitution - Missense 38 7:55142424-55142424 + - PATHOGENIC .97399 Variant of unknown origin 22675565 cell-line NS ENSP00000413843.2:p.Leu76Pro ENST00000420316.6:c.227T>C 7:g.55142424T>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TMIT_I_12 2765652 2623896 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV99034441 COSM7346604 124950744 c.1123G>A p.A375T Substitution - Missense 38 7:55156649-55156649 + - PATHOGENIC .97686 Variant of unknown origin 30239046 surgery-fixed NS ENSP00000413843.2:p.Ala375Thr ENST00000420316.6:c.1123G>A 7:g.55156649G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2579503 2579503 2440840 NS NS NS NS malignant_melanoma NS NS NS n COSV51849040 COSM6005740 124960251 c.353C>T p.A118V Substitution - Missense 38 7:55143417-55143417 + - PATHOGENIC .99538 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000413843.2:p.Ala118Val ENST00000420316.6:c.353C>T 7:g.55143417C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 NPC0001PT00243T00243 2857340 2712640 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105111181 COSM9542450 124958405 c.61G>A p.A21T Substitution - Missense 38 7:55019338-55019338 + - NEUTRAL .06121 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000413843.2:p.Ala21Thr ENST00000420316.6:c.61G>A 7:g.55019338G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 NPC0001PT00389T00389 2857373 2712673 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV105110096 COSM9542454 124958424 c.1162G>A p.D388N Substitution - Missense 38 7:55156787-55156787 + - PATHOGENIC .98375 Variant of unknown origin 28851814 surgery-fixed primary ENSP00000413843.2:p.Asp388Asn ENST00000420316.6:c.1162G>A 7:g.55156787G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2626094 2626094 2486506 lung NS NS NS carcinoid-endocrine_tumour atypical NS NS n COSV51823853 COSM6191491 124947473 c.311T>A p.L104Q Substitution - Missense hom 38 7:55143375-55143375 + - PATHOGENIC .99116 Variant of unknown origin 26645239 surgery-fixed NS ENSP00000413843.2:p.Leu104Gln ENST00000420316.6:c.311T>A 7:g.55143375T>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2732608 2732608 2591361 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779091 COSM2155593 124952264 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Reported in another cancer sample as somatic 26757882 surgery-fixed primary 57 ENSP00000413843.2:p.Thr363Ile ENST00000420316.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 1047 2491942 2354571 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour borderline NS n COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 26437033 surgery fresh/frozen NS 63 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2579438 2579438 2440775 NS NS NS NS malignant_melanoma NS NS NS n COSV51781415 COSM6005739 124962183 c.326G>A p.G109E Substitution - Missense 38 7:55143390-55143390 + - PATHOGENIC .99562 Variant of unknown origin 25148578 surgery-fixed NS ENSP00000413843.2:p.Gly109Glu ENST00000420316.6:c.326G>A 7:g.55143390G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2732913 2732913 2591666 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 124948622 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 60 ENSP00000413843.2:p.Ala289Asp ENST00000420316.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 AC-V10-Tumor-SM-9J465 2584480 2445644 large_intestine anus NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51802062 COSM6008937 124951524 c.659C>T p.S220F Substitution - Missense 38 7:55152576-55152576 + - PATHOGENIC .98424 Variant of unknown origin 27852700 surgery-fixed primary ENSP00000413843.2:p.Ser220Phe ENST00000420316.6:c.659C>T 7:g.55152576C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2509044 2509044 2371379 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 49 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-05-4410-01 1780064 1684063 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51823181 COSM6110421 124961476 c.1131G>T p.R377S Substitution - Missense 38 7:55156657-55156657 + - NEUTRAL .42615 Variant of unknown origin 417 fresh/frozen - NOS primary 62 ENSP00000413843.2:p.Arg377Ser ENST00000420316.6:c.1131G>T 7:g.55156657G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2808101 2808101 2664786 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 31258848 surgery-fixed NS 60 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 MBC067T 2807243 2663947 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV99294040 COSM9120802 124953605 c.379G>A p.A127T Substitution - Missense 38 7:55143443-55143443 + - NEUTRAL .01752 Reported in another cancer sample as somatic 31340200 surgery - NOS NS ENSP00000413843.2:p.Ala127Thr ENST00000420316.6:c.379G>A 7:g.55143443G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-02-0023-01 1910131 1798422 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 38 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 SA-N101 2521507 2383850 central_nervous_system spinal_cord NS NS glioma astrocytoma_Grade_II fibrillary NS n COSV51785554 COSM21688 124947980 c.971G>T p.R324L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Reported in another cancer sample as somatic 26487540 surgery-fixed NS 82 ENSP00000413843.2:p.Arg324Leu ENST00000420316.6:c.971G>T 7:g.55155911G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2509057 2509057 2371392 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51783296 COSM5878511 124964511 c.661G>T p.G221W Substitution - Missense 38 7:55152578-55152578 + - NEUTRAL .4823 Variant of unknown origin 26919320 surgery - NOS NS 43 ENSP00000413843.2:p.Gly221Trp ENST00000420316.6:c.661G>T 7:g.55152578G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S001097 1027690 944666 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 124948622 c.866C>A p.A289D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000413843.2:p.Ala289Asp ENST00000420316.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-08-0390-01 1910243 1798534 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 69 ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-08-0390-01 1910243 1798534 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51822289 COSM42977 124956750 c.315G>T p.Q105H Substitution - Missense het 38 7:55143379-55143379 + - PATHOGENIC .90579 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 69 ENSP00000413843.2:p.Gln105His ENST00000420316.6:c.315G>T 7:g.55143379G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2696526 2696526 2555430 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 28201779 surgery fresh/frozen NS 72 ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2732900 2732900 2591653 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 63 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2819307 2819307 2675606 lung left_upper_lobe NS NS carcinoma invasive_mucinous_adenocarcinoma NS NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 30572543 circulating tumour NS 80 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2509042 2509042 2371377 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 124949356 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 26919320 surgery - NOS NS 74 ENSP00000413843.2:p.Thr263Pro ENST00000420316.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2732920 2732920 2591673 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 124949356 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 73 ENSP00000413843.2:p.Thr263Pro ENST00000420316.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 9VWJAP 2762757 2621016 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51826193 COSM7340403 124953722 c.458A>G p.N153S Substitution - Missense 38 7:55146639-55146639 + - PATHOGENIC .99355 Reported in another cancer sample as somatic 29615459 NS NS 71 ENSP00000413843.2:p.Asn153Ser ENST00000420316.6:c.458A>G 7:g.55146639A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2732919 2732919 2591672 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 124949356 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 73 ENSP00000413843.2:p.Thr263Pro ENST00000420316.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 1194729 1194729 1106624 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0127-01 1910170 1798461 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766389 COSM43067 124957660 c.874G>T p.V292L Substitution - Missense het 38 7:55154137-55154137 + - PATHOGENIC .98997 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 67 ENSP00000413843.2:p.Val292Leu ENST00000420316.6:c.874G>T 7:g.55154137G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2855910 2855910 2711313 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV104368998 COSM9232920 124953625 c.886C>T p.P296S Substitution - Missense 38 7:55154149-55154149 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 32269842 surgery-fixed NS 58 ENSP00000413843.2:p.Pro296Ser ENST00000420316.6:c.886C>T 7:g.55154149C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2732901 2732901 2591654 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 63 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0157-01 1910184 1798475 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 63 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2732886 2732886 2591639 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51779091 COSM2155593 124952264 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 50 ENSP00000413843.2:p.Thr363Ile ENST00000420316.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 NPC0002PT00013T00013 2857370 2712670 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma non_keratinizing NS y COSV99291226 COSM7552389 124957914 c.1124C>T p.A375V Substitution - Missense 38 7:55156650-55156650 + - PATHOGENIC .98971 Reported in another cancer sample as somatic 28851814 surgery-fixed primary ENSP00000413843.2:p.Ala375Val ENST00000420316.6:c.1124C>T 7:g.55156650C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2701162 2701162 2560066 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma squamous_cell_carcinoma NS NS n COSV51822289 COSM42977 124956750 c.315G>T p.Q105H Substitution - Missense het 38 7:55143379-55143379 + - PATHOGENIC .90579 Reported in another cancer sample as somatic 28581676 surgery-fixed NS 41 ENSP00000413843.2:p.Gln105His ENST00000420316.6:c.315G>T 7:g.55143379G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2732921 2732921 2591674 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 49 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2878966 2878966 2733481 oesophagus NS NS NS carcinoma sarcomatoid_carcinoma NS NS n COSV51813913 COSM6023901 124950656 c.344A>C p.N115T Substitution - Missense 38 7:55143408-55143408 + - PATHOGENIC .92454 Reported in another cancer sample as somatic 33115932 surgery-fixed NS 68 ENSP00000413843.2:p.Asn115Thr ENST00000420316.6:c.344A>C 7:g.55143408A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2732924 2732924 2591677 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 64 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 BL-14-R46791 2905653 2759909 NS NS NS NS malignant_melanoma NS NS NS n COSV51844648 COSM6971178 124950783 c.820A>G p.T274A Substitution - Missense 38 7:55154083-55154083 + - PATHOGENIC .96224 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000413843.2:p.Thr274Ala ENST00000420316.6:c.820A>G 7:g.55154083A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 HN_62506 1560544 1481994 upper_aerodigestive_tract larynx NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51818237 COSM122787 124962361 c.534G>T p.M178I Substitution - Missense 38 7:55146715-55146715 + - PATHOGENIC .7306 Reported in another cancer sample as somatic 21798893 surgery fresh/frozen primary ENSP00000413843.2:p.Met178Ile ENST00000420316.6:c.534G>T 7:g.55146715G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-38-4627-01 1780091 1684090 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 417 fresh/frozen - NOS primary 64 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 BL-17-G34953 2905427 2759683 lung NS NS NS carcinoma non_small_cell_carcinoma NS NS n COSV51788796 COSM4680390 124956395 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000413843.2:p.Arg98Gln ENST00000420316.6:c.293G>A 7:g.55143357G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 BL-16-A36234 2905681 2759937 large_intestine NS NS NS carcinoma adenocarcinoma NS NS n COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 32321774 surgery-fixed primary ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 1194728 1194728 1106623 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 8LFG8F 2762947 2621206 thyroid NS NS NS carcinoma papillary_carcinoma NS NS n COSV51839851 COSM7340115 124957750 c.1118C>A p.P373Q Substitution - Missense 38 7:55156644-55156644 + - PATHOGENIC .76649 Reported in another cancer sample as somatic 29615459 NS metastasis 45 ENSP00000413843.2:p.Pro373Gln ENST00000420316.6:c.1118C>A 7:g.55156644C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-02-0021-01 1910130 1798421 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 124950070 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 44 ENSP00000413843.2:p.Arg252Cys ENST00000420316.6:c.754C>T 7:g.55154017C>T TAF4B_ENST00000269142 ENST00000269142.9 2589 11538 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105870114 COSM10012788 100034702 c.877C>T p.L293F Substitution - Missense 38 18:26275048-26275048 + - PATHOGENIC .92408 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000269142.5:p.Leu293Phe ENST00000269142.9:c.877C>T 18:g.26275048C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 1194730 1194730 1106625 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T ZNF845_ENST00000595091 ENST00000595091.6 2913 25112 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV72003978 COSM369429 164543287 c.2774G>A p.R925H Substitution - Missense 38 19:53353449-53353449 + - NEUTRAL .01601 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000470005.1:p.Arg925His ENST00000595091.6:c.2774G>A 19:g.53353449G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-AS-3778-01 1779806 1683805 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51831642 COSM1496684 124952152 c.988G>A p.E330K Substitution - Missense 38 7:55155928-55155928 + - PATHOGENIC .94538 Reported in another cancer sample as somatic 416 fresh/frozen - NOS primary 35 ENSP00000413843.2:p.Glu330Lys ENST00000420316.6:c.988G>A 7:g.55155928G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0219-01 1910209 1798500 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 67 ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2696524 2696524 2555428 central_nervous_system middle_frontal_gyrus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28201779 surgery fresh/frozen NS 56 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 BL-17-J45330 2905663 2759919 NS NS NS NS malignant_melanoma NS NS NS n COSV51777851 COSM1205052 124954369 c.494G>A p.R165Q Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .0375 Reported in another cancer sample as somatic 32321774 surgery-fixed metastasis ENSP00000413843.2:p.Arg165Gln ENST00000420316.6:c.494G>A 7:g.55146675G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S002024 1027695 944671 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51785554 COSM21688 124947980 c.971G>T p.R324L Substitution - Missense het 38 7:55155911-55155911 + - PATHOGENIC .97287 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000413843.2:p.Arg324Leu ENST00000420316.6:c.971G>T 7:g.55155911G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0154-01 1910182 1798473 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense hom 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 55 ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 618-1503-04TD 1921502 1808820 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51797215 COSM145360 124951679 c.967G>A p.V323I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Reported in another cancer sample as somatic 340 blood NS ENSP00000413843.2:p.Val323Ile ENST00000420316.6:c.967G>A 7:g.55155907G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 1194725 1194725 1106620 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 124948622 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000413843.2:p.Ala289Asp ENST00000420316.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2785975 2785975 2643435 large_intestine colon ascending NS carcinoma neuroendocrine_carcinoma NS NS n COSV51781835 COSM174732 124949519 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Reported in another cancer sample as somatic 28730258 surgery-fixed primary 61 ENSP00000413843.2:p.Glu114Lys ENST00000420316.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2579398 2579398 2440735 NS NS NS NS malignant_melanoma NS NS NS n COSV51788796 COSM4680390 124956395 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000413843.2:p.Arg98Gln ENST00000420316.6:c.293G>A 7:g.55143357G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2840788 2840788 2696348 prostate NS NS NS carcinoma NS NS NS n COSV51785413 COSM1176673 124950736 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 31874108 surgery-fixed metastasis ENSP00000413843.2:p.Arg252His ENST00000420316.6:c.755G>A 7:g.55154018G>A GNL2 ENST00000373062.7 2196 29925 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105926521 COSM10012888 112787877 c.889C>A p.L297I Substitution - Missense 38 1:37582243-37582243 - - PATHOGENIC .99404 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000362153.3:p.Leu297Ile ENST00000373062.7:c.889C>A 1:g.37582243G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2732896 2732896 2591649 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28855349 surgery - NOS recurrent 58 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2808102 2808102 2664786 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 31258848 surgery-fixed NS 60 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-02-0007-01 1910125 1798416 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 124949356 c.787A>C p.T263P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 42 ENSP00000413843.2:p.Thr263Pro ENST00000420316.6:c.787A>C 7:g.55154050A>C FBXL7_ENST00000510662 ENST00000510662.1 1335 13604 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV61649228 COSM5743062 145517270 c.995G>A p.R332H Substitution - Missense 38 5:15936846-15936846 + - PATHOGENIC .98974 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000425184.1:p.Arg332His ENST00000510662.1:c.995G>A 5:g.15936846G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2579649 2579649 2440986 NS NS NS NS malignant_melanoma NS NS NS n COSV51781835 COSM174732 124949519 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Reported in another cancer sample as somatic 25148578 surgery-fixed NS ENSP00000413843.2:p.Glu114Lys ENST00000420316.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S001095 1027691 944667 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-02-0089-01 1910158 1798449 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense hom 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 54 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0237-01 1910211 1798502 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense hom 38 7:55142382-55142382 + - PATHOGENIC .98271 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 75 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 5-GE101-T1 2869805 2724802 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51822498 COSM3266565 124960202 c.917C>T p.S306L Substitution - Missense 38 7:55155857-55155857 + - PATHOGENIC .98807 Reported in another cancer sample as somatic 26950094 surgery - NOS NS 81 ENSP00000413843.2:p.Ser306Leu ENST00000420316.6:c.917C>T 7:g.55155857C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 SJHGG120_D 2307435 2172639 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Reported in another cancer sample as somatic 24705251 surgery - NOS NS 12 ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-02-0016-01 1910129 1798420 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense hom 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 329 fresh/frozen - NOS primary 50 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-RR-A6KC-01 2339255 2204238 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 124950070 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 NS primary 55 ENSP00000413843.2:p.Arg252Cys ENST00000420316.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 T155 1861137 1752078 endometrium NS NS NS carcinoma serous_carcinoma NS NS y COSV51785413 COSM1176673 124950736 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 23104009 surgery fresh/frozen primary ENSP00000413843.2:p.Arg252His ENST00000420316.6:c.755G>A 7:g.55154018G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0004119-T01-IM5 2720520 2579341 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 124950070 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg252Cys ENST00000420316.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 SNU-C2B 2302010 2167293 large_intestine colon right NS carcinoma adenocarcinoma NS NS y COSV51777851 COSM1205052 124954369 c.494G>A p.R165Q Substitution - Missense het 38 7:55146675-55146675 + - NEUTRAL .0375 Reported in another cancer sample as somatic 24755471 cell-line NS ENSP00000413843.2:p.Arg165Gln ENST00000420316.6:c.494G>A 7:g.55146675G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0004491-T01-IM5 2720890 2579711 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 28481359 surgery - NOS primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S001067 1027687 944663 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 124949356 c.787A>C p.T263P Substitution - Missense hom 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000413843.2:p.Thr263Pro ENST00000420316.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 EXTERN_MELA_20140526_088 2839362 2695128 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 124949843 c.1168C>A p.Q390K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000413843.2:p.Gln390Lys ENST00000420316.6:c.1168C>A 7:g.55156793C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S003763 1027686 944662 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-BS-A0UV-01 1783478 1687477 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51773524 COSM1090858 124948180 c.418T>G p.L140V Substitution - Missense het 38 7:55143482-55143482 + - NEUTRAL .25717 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 55 ENSP00000413843.2:p.Leu140Val ENST00000420316.6:c.418T>G 7:g.55143482T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S001108 1027693 944669 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 17177598 cell-line NS ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2732912 2732912 2591665 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 124948622 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 60 ENSP00000413843.2:p.Ala289Asp ENST00000420316.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 1194731 1194731 1106626 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 19284481 surgery fresh/frozen primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2840787 2840787 2696347 prostate NS NS NS carcinoma NS NS NS n COSV51785413 COSM1176673 124950736 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Reported in another cancer sample as somatic 31874108 surgery-fixed primary ENSP00000413843.2:p.Arg252His ENST00000420316.6:c.755G>A 7:g.55154018G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0649 2107982 1985843 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51791901 COSM2151461 124961325 c.991G>A p.G331R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .96902 Confirmed somatic variant 23917401 NS NS ENSP00000413843.2:p.Gly331Arg ENST00000420316.6:c.991G>A 7:g.55155931G>A TTN_ENST00000359218 ENST00000359218.10 81156 12403 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV59957361 COSM130006 108426512 c.184C>T p.R62C Substitution - Missense 38 2:178802249-178802249 - - PATHOGENIC .99021 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000352154.5:p.Arg62Cys ENST00000359218.10:c.184C>T 2:g.178802249G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2732923 2732923 2591676 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Reported in another cancer sample as somatic 28855349 surgery - NOS primary 64 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 CSCC-40-T 2292477 2158541 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51858853 COSM4512041 124966561 c.889C>T p.R297C Substitution - Missense het 38 7:55154152-55154152 + - PATHOGENIC .97012 Confirmed somatic variant 25303977 surgery fresh/frozen metastasis 49 ENSP00000413843.2:p.Arg297Cys ENST00000420316.6:c.889C>T 7:g.55154152C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 PD_06 2688647 2547629 skin face NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51852113 COSM4501266 124953499 c.584C>T p.P195L Substitution - Missense het 38 7:55151318-55151318 + - NEUTRAL .31382 Confirmed somatic variant 24662767 surgery fresh/frozen NS 75 ENSP00000413843.2:p.Pro195Leu ENST00000420316.6:c.584C>T 7:g.55151318C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-DU-7012-01 2194261 2062539 central_nervous_system brain NS NS glioma NS NS NS y COSV51774829 COSM1451549 124948462 c.767A>G p.D256G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 545 NS NS 74 ENSP00000413843.2:p.Asp256Gly ENST00000420316.6:c.767A>G 7:g.55154030A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-AP-A051-01 1783330 1687329 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV51837186 COSM1090861 124952337 c.442G>A p.V148M Substitution - Missense het 38 7:55146623-55146623 + - PATHOGENIC .99004 Reported in another cancer sample as somatic 419 fresh/frozen - NOS primary 69 ENSP00000413843.2:p.Val148Met ENST00000420316.6:c.442G>A 7:g.55146623G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GBM19-I1 2813465 2669857 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GB013T 2633978 2494374 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51855854 COSM6355744 124961570 c.977G>T p.C326F Substitution - Missense 38 7:55155917-55155917 + - PATHOGENIC .99445 Confirmed somatic variant 672 NS primary ENSP00000413843.2:p.Cys326Phe ENST00000420316.6:c.977G>T 7:g.55155917G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GBM13-I3 2813477 2669869 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28263318 surgery fresh/frozen NS 55 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0007024-T01-IM5 2723398 2582219 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51786507 COSM6955643 124960922 c.1118C>T p.P373L Substitution - Missense het 38 7:55156644-55156644 + - PATHOGENIC .86501 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Pro373Leu ENST00000420316.6:c.1118C>T 7:g.55156644C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0007024-T01-IM5 2723398 2582219 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 5-VS033-T2 2869855 2724852 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51776559 COSM4892884 124950311 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 26950094 surgery - NOS NS 73 ENSP00000413843.2:p.Pro100Ser ENST00000420316.6:c.298C>T 7:g.55143362C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S004384 1027694 944670 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Reported in another cancer sample as somatic 17177598 fresh/frozen - NOS NS ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GB051T 2634016 2494412 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51846086 COSM6354719 124969242 c.178G>A p.V60M Substitution - Missense 38 7:55142375-55142375 + - PATHOGENIC .96004 Confirmed somatic variant 672 NS primary ENSP00000413843.2:p.Val60Met ENST00000420316.6:c.178G>A 7:g.55142375G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 MSU2-a 2809971 2666633 large_intestine caecum NS NS adenoma villous NS NS y COSV51784286 COSM6652281 124950832 c.116C>T p.T39M Substitution - Missense 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 26336987 surgery fresh/frozen primary 66 ENSP00000413843.2:p.Thr39Met ENST00000420316.6:c.116C>T 7:g.55142313C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 ESCC_35 2479543 2342303 oesophagus NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51774192 COSM5628704 124963308 c.596G>C p.C199S Substitution - Missense 38 7:55151330-55151330 + - PATHOGENIC .99573 Confirmed somatic variant 26873401 NS NS 68 ENSP00000413843.2:p.Cys199Ser ENST00000420316.6:c.596G>C 7:g.55151330G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GB057T 2634022 2494418 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 672 NS primary ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A HMGB1 ENST00000341423.9 648 4983 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV58104601 COSM3813701 107536547 c.630A>T p.E210D Substitution - Missense 38 13:30461375-30461375 - - .57857 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000345347.5:p.Glu210Asp ENST00000341423.9:c.630A>T 13:g.30461375T>A DCAF4 ENST00000358377.6 1488 20229 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105912372 COSM10012834 110253762 c.320G>A p.R107Q Substitution - Missense 38 14:72940346-72940346 + - NEUTRAL .14934 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000351147.2:p.Arg107Gln ENST00000358377.6:c.320G>A 14:g.72940346G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-FG-6692-01 2194411 2062689 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 63 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 non-ocular_carcinoma_3 2580640 2441977 skin neck NS NS adnexal_tumour sebaceous_carcinoma NS NS n COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 27287813 surgery-fixed primary ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T ITGA11 ENST00000315757.8 3567 6136 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105878574 COSM10012779 103999830 c.2947G>A p.G983R Substitution - Missense 38 15:68312799-68312799 - - PATHOGENIC .94772 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000327290.7:p.Gly983Arg ENST00000315757.8:c.2947G>A 15:g.68312799C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-16-1045-01 1338027 1248412 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 124949356 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 surgery fresh/frozen NS 49 ENSP00000413843.2:p.Thr263Pro ENST00000420316.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2876663 2876663 2731178 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 surgery fresh/frozen NS 60 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0000677-T01-IM3 2715765 2574586 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51860516 COSM6911906 124956433 c.1143C>G p.F381L Substitution - Missense het 38 7:55156768-55156768 + - PATHOGENIC .96387 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Phe381Leu ENST00000420316.6:c.1143C>G 7:g.55156768C>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 ICGC_GBM53_tumor 2634861 2495257 central_nervous_system brain NS NS primitive_neuroectodermal_tumour-medulloblastoma NS NS NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 379 NS primary 5 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 124948622 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000413843.2:p.Ala289Asp ENST00000420316.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0750-01 1337862 1248247 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 43 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009856-T01-IM5 2725695 2584516 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51844648 COSM6971178 124950783 c.820A>G p.T274A Substitution - Missense het 38 7:55154083-55154083 + - PATHOGENIC .96224 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000413843.2:p.Thr274Ala ENST00000420316.6:c.820A>G 7:g.55154083A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 004 2492942 2355556 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour benign NS n COSV51768130 COSM21684 124949356 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 26437033 NS NS ENSP00000413843.2:p.Thr263Pro ENST00000420316.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-12-3652-01 2120285 1994521 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51800797 COSM3412178 124951443 c.755G>C p.R252P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 329 NS NS 60 ENSP00000413843.2:p.Arg252Pro ENST00000420316.6:c.755G>C 7:g.55154018G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003360-T01-IM5 2719851 2578672 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0749-01 1337861 1248246 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0004971-T01-IM5 2721381 2580202 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 PD6907a 1504118 1426996 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_anaemia_with_excess_blasts NS n COSV51857264 COSM4384115 124965146 c.727C>T p.P243S Substitution - Missense 38 7:55152644-55152644 + - PATHOGENIC .99273 Confirmed somatic variant 24030381 NS NS ENSP00000413843.2:p.Pro243Ser ENST00000420316.6:c.727C>T 7:g.55152644C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 R098-I1 2813503 2669895 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 124949417 c.809A>G p.Y270C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 28263318 surgery fresh/frozen NS 51 ENSP00000413843.2:p.Tyr270Cys ENST00000420316.6:c.809A>G 7:g.55154072A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-FP-7829-01 2198081 2066359 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51829933 COSM3881812 124955863 c.971G>A p.R324H Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .95186 Confirmed somatic variant 541 NS NS 69 ENSP00000413843.2:p.Arg324His ENST00000420316.6:c.971G>A 7:g.55155911G>A TTN_ENST00000359218 ENST00000359218.10 81156 12403 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105912072 COSM10012820 108335446 c.9405A>T p.K3135N Substitution - Missense 38 2:178766541-178766541 - - PATHOGENIC .90433 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000352154.5:p.Lys3135Asn ENST00000359218.10:c.9405A>T 2:g.178766541T>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GBM19-I2 2813466 2669858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0004846-T01-IM5 2721249 2580070 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51779091 COSM2155593 124952264 c.1088C>T p.T363I Substitution - Missense het 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000413843.2:p.Thr363Ile ENST00000420316.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0014258-T01-IM6 2803906 2660656 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS n COSV51826193 COSM7340403 124953722 c.458A>G p.N153S Substitution - Missense het 38 7:55146639-55146639 + - PATHOGENIC .99355 Confirmed somatic variant 29316426 surgery-fixed primary 69 ENSP00000413843.2:p.Asn153Ser ENST00000420316.6:c.458A>G 7:g.55146639A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-D8-A1JF-01 1900052 1788736 breast NS NS NS carcinoma NS NS NS y COSV51781835 COSM174732 124949519 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 414 fresh/frozen - NOS primary 79 ENSP00000413843.2:p.Glu114Lys ENST00000420316.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003222-T01-IM5 2719716 2578537 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51841941 COSM6927106 124948821 c.846G>T p.E282D Substitution - Missense het 38 7:55154109-55154109 + - NEUTRAL .06117 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000413843.2:p.Glu282Asp ENST00000420316.6:c.846G>T 7:g.55154109G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-19-1789 2108040 1985901 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51850088 COSM2156010 124956911 c.1000C>T p.R334C Substitution - Missense 38 7:55155940-55155940 + - PATHOGENIC .91604 Confirmed somatic variant 23917401 NS NS ENSP00000413843.2:p.Arg334Cys ENST00000420316.6:c.1000C>T 7:g.55155940C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0006399-T01-IM5 2722775 2581596 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843352 COSM6950555 124960642 c.530C>T p.S177L Substitution - Missense het 38 7:55146711-55146711 + - NEUTRAL .28714 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000413843.2:p.Ser177Leu ENST00000420316.6:c.530C>T 7:g.55146711C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0000906-T01-IM3 2716233 2575054 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765787 COSM2149971 124949126 c.910C>T p.H304Y Substitution - Missense het 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.His304Tyr ENST00000420316.6:c.910C>T 7:g.55155850C>T KSR1_ENST00000644974 ENST00000644974.1 2787 6465 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105903017 COSM10012790 175888144 c.110C>A p.A37E Substitution - Missense 38 17:27456753-27456753 + - PATHOGENIC .92237 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000494552.1:p.Ala37Glu ENST00000644974.1:c.110C>A 17:g.27456753C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-QH-A6CX-01 2263100 2130084 central_nervous_system brain NS NS glioma NS NS NS y COSV51785554 COSM21688 124947980 c.971G>T p.R324L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 545 NS primary 66 ENSP00000413843.2:p.Arg324Leu ENST00000420316.6:c.971G>T 7:g.55155911G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-AO-A12G-01 1899795 1788479 breast NS NS NS carcinoma NS NS NS y COSV51772564 COSM453241 124955123 c.817A>G p.T273A Substitution - Missense 38 7:55154080-55154080 + - PATHOGENIC .94785 Confirmed somatic variant 414 fresh/frozen - NOS primary 75 ENSP00000413843.2:p.Thr273Ala ENST00000420316.6:c.817A>G 7:g.55154080A>G KANK1_ENST00000382297 ENST00000382297.6 4059 19309 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105916423 COSM10012928 116946669 c.3077A>G p.D1026G Substitution - Missense 38 9:732449-732449 + - PATHOGENIC .96909 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000371734.2:p.Asp1026Gly ENST00000382297.6:c.3077A>G 9:g.732449A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0008258-T01-IM5 2724397 2583218 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-05-4382-01 1780053 1684052 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV99288189 COSM7821080 124955803 c.665G>T p.R222L Substitution - Missense 38 7:55152582-55152582 + - PATHOGENIC .99698 Confirmed somatic variant 417 fresh/frozen - NOS primary 68 ENSP00000413843.2:p.Arg222Leu ENST00000420316.6:c.665G>T 7:g.55152582G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-2565 2108006 1985867 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 23917401 NS NS ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GBM_IV-39 2354294 2218452 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51778955 COSM4967262 124955177 c.680C>A p.S227Y Substitution - Missense 38 7:55152597-55152597 + - NEUTRAL .32595 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000413843.2:p.Ser227Tyr ENST00000420316.6:c.680C>A 7:g.55152597C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-E1-A7YM-01 2457423 2320260 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 63 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-HT-A61C-01 2386268 2249100 central_nervous_system brain NS NS glioma NS NS NS y COSV51768130 COSM21684 124949356 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 545 NS primary 66 ENSP00000413843.2:p.Thr263Pro ENST00000420316.6:c.787A>C 7:g.55154050A>C CLCNKA ENST00000331433.4 2064 2026 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV58890629 COSM1737785 103937187 c.1729A>G p.T577A Substitution - Missense 38 1:16031816-16031816 + - NEUTRAL .00395 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000332771.4:p.Thr577Ala ENST00000331433.4:c.1729A>G 1:g.16031816A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009327-T01-IM5 2725273 2584094 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0005127-T02-IM5 2721531 2580352 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51802355 COSM6941144 124948406 c.1154C>T p.P385L Substitution - Missense het 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Pro385Leu ENST00000420316.6:c.1154C>T 7:g.55156779C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0005127-T02-IM5 2721531 2580352 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51794869 COSM4362780 124948381 c.574C>T p.P192S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Pro192Ser ENST00000420316.6:c.574C>T 7:g.55151308C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 1194722 1194722 1106617 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51824149 COSM29338 124948562 c.178G>C p.V60L Substitution - Missense 38 7:55142375-55142375 + - PATHOGENIC .98023 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000413843.2:p.Val60Leu ENST00000420316.6:c.178G>C 7:g.55142375G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0010613-T01-IM5 2726312 2585133 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A KCNK2_ENST00000391895 ENST00000391895.6 1269 6277 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105930970 COSM10012965 117400230 c.264G>T p.R88S Substitution - Missense 38 1:215086597-215086597 + - PATHOGENIC .96743 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000375765.2:p.Arg88Ser ENST00000391895.6:c.264G>T 1:g.215086597G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003128-T01-IM5 2719622 2578443 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T FCGR3A_ENST00000367967 ENST00000367967.7 765 3619 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV63460316 COSM4224348 109797207 c.254G>T p.G85V Substitution - Missense 38 1:161548486-161548486 - - .64272 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000356944.3:p.Gly85Val ENST00000367967.7:c.254G>T 1:g.161548486C>A IARS_ENST00000443024 ENST00000443024.6 3729 5330 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105927180 COSM10012856 130445583 c.1552C>T p.H518Y Substitution - Missense 38 9:92265077-92265077 - - PATHOGENIC .91051 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000406448.3:p.His518Tyr ENST00000443024.6:c.1552C>T 9:g.92265077G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 YUKAT 2439331 2302172 skin NS NS NS malignant_melanoma NS NS NS y COSV51838161 COSM5407720 124948696 c.994C>T p.P332S Substitution - Missense het 38 7:55155934-55155934 + - PATHOGENIC .91925 Confirmed somatic variant 26214590 fresh/frozen - NOS metastasis 78 ENSP00000413843.2:p.Pro332Ser ENST00000420316.6:c.994C>T 7:g.55155934C>T ADAMTS19 ENST00000638972.1 3624 17111 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105859138 COSM10012952 172389855 c.3550G>T p.D1184Y Substitution - Missense 38 5:129737144-129737144 + - PATHOGENIC .98099 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000491408.1:p.Asp1184Tyr ENST00000638972.1:c.3550G>T 5:g.129737144G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-BR-4184-01 2198083 2066361 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51818237 COSM122787 124962361 c.534G>T p.M178I Substitution - Missense 38 7:55146715-55146715 + - PATHOGENIC .7306 Confirmed somatic variant 541 NS NS 70 ENSP00000413843.2:p.Met178Ile ENST00000420316.6:c.534G>T 7:g.55146715G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-ER-A19E-06 2121716 1995952 skin NS NS NS malignant_melanoma NS NS NS y COSV51817262 COSM3639733 124968037 c.955G>A p.E319K Substitution - Missense 38 7:55155895-55155895 + - PATHOGENIC .99356 Confirmed somatic variant 540 NS NS 36 ENSP00000413843.2:p.Glu319Lys ENST00000420316.6:c.955G>A 7:g.55155895G>A KSR1_ENST00000644974 ENST00000644974.1 2787 6465 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105903016 COSM10012905 175888133 c.95C>T p.A32V Substitution - Missense 38 17:27456738-27456738 + - NEUTRAL .39701 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000494552.1:p.Ala32Val ENST00000644974.1:c.95C>T 17:g.27456738C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009048-T01-IM5 2725037 2583858 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S001090 1027692 944668 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-14-1034-01 2178234 2046532 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51775191 COSM1451530 124948556 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 329 NS NS 60 ENSP00000413843.2:p.Gly63Arg ENST00000420316.6:c.187G>A 7:g.55142384G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 13T 2139248 2008776 upper_aerodigestive_tract mouth gingiva NS carcinoma squamous_cell_carcinoma NS NS y COSV51815394 COSM3715755 124951042 c.738C>A p.S246R Substitution - Missense 38 7:55152655-55152655 + - NEUTRAL .15461 Confirmed somatic variant 24292195 NS NS ENSP00000413843.2:p.Ser246Arg ENST00000420316.6:c.738C>A 7:g.55152655C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0005400-T01-IM5 2721802 2580623 biliary_tract bile_duct NS NS carcinoma adenocarcinoma NS NS n COSV51781835 COSM174732 124949519 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000413843.2:p.Glu114Lys ENST00000420316.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009357-T01-IM5 2725300 2584121 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 PD25645c 2843020 2698474 skin mucosal sinonasal NS malignant_melanoma NS NS NS y COSV104576411 COSM9505912 124970968 c.881A>T p.K294M Substitution - Missense 38 7:55154144-55154144 + - PATHOGENIC .88176 Confirmed somatic variant 30664638 surgery-fixed primary 58 ENSP00000413843.2:p.Lys294Met ENST00000420316.6:c.881A>T 7:g.55154144A>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-CG-5721-01 2198017 2066295 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51782832 COSM3881808 124960282 c.739G>A p.D247N Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .98807 Confirmed somatic variant 541 NS NS 58 ENSP00000413843.2:p.Asp247Asn ENST00000420316.6:c.739G>A 7:g.55152656G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-22-4609-01 2195227 2063505 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51827895 COSM3412174 124949492 c.685A>T p.S229C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 418 NS NS 81 ENSP00000413843.2:p.Ser229Cys ENST00000420316.6:c.685A>T 7:g.55152602A>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009527-T01-IM5 2725444 2584265 skin NS NS NS malignant_melanoma NS NS NS n COSV51794946 COSM6969229 124948103 c.353_354delinsTT p.A118V Substitution - Missense het 38 7:55143417-55143418 + - Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Ala118Val ENST00000420316.6:c.353_354delinsTT 7:g.55143417_55143418delinsTT EVA1C ENST00000300255.6 1326 13239 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105891752 COSM10012968 100673176 c.880G>A p.G294R Substitution - Missense 38 21:32503946-32503946 + - NEUTRAL .06179 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000300255.2:p.Gly294Arg ENST00000300255.6:c.880G>A 21:g.32503946G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 1194727 1194727 1106622 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-GN-A8LN-01 2339478 2204461 skin NS NS NS malignant_melanoma NS NS NS y COSV99295991 COSM7976081 124959557 c.1135G>A p.D379N Substitution - Missense 38 7:55156760-55156760 + - PATHOGENIC .99676 Confirmed somatic variant 540 NS primary 68 ENSP00000413843.2:p.Asp379Asn ENST00000420316.6:c.1135G>A 7:g.55156760G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2492702 2492702 2355317 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 124956593 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000413843.2:p.His47Tyr ENST00000420316.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-GN-A8LN-01 2339478 2204461 skin NS NS NS malignant_melanoma NS NS NS y COSV99295987 COSM7976353 124959528 c.815C>T p.P272L Substitution - Missense 38 7:55154078-55154078 + - PATHOGENIC .98876 Confirmed somatic variant 540 NS primary 68 ENSP00000413843.2:p.Pro272Leu ENST00000420316.6:c.815C>T 7:g.55154078C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0747-01 1337860 1248245 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 53 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 T341 2658331 2518490 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51784286 COSM6652281 124950832 c.116C>T p.T39M Substitution - Missense 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 27149842 NS NS 66.58 ENSP00000413843.2:p.Thr39Met ENST00000420316.6:c.116C>T 7:g.55142313C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-CV-7250-01 2193784 2062062 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51827895 COSM3412174 124949492 c.685A>T p.S229C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 627 NS NS 64 ENSP00000413843.2:p.Ser229Cys ENST00000420316.6:c.685A>T 7:g.55152602A>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 W16T 2745047 2603750 thyroid NS NS NS carcinoma NS NS NS y COSV51794993 COSM6399094 124954184 c.5G>A p.R2Q Substitution - Missense 38 7:55019282-55019282 + - NEUTRAL .46409 Confirmed somatic variant 676 NS primary 40 ENSP00000413843.2:p.Arg2Gln ENST00000420316.6:c.5G>A 7:g.55019282G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0010004-T01-IM5 2725823 2584644 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-S9-A7R2-01 2263272 2130256 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 69 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2857119 2857119 2712419 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV105110043 COSM9533927 124962827 c.175G>A p.E59K Substitution - Missense 38 7:55142372-55142372 + - PATHOGENIC .93877 Confirmed somatic variant 25096233 surgery - NOS NS ENSP00000413843.2:p.Glu59Lys ENST00000420316.6:c.175G>A 7:g.55142372G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-QB-AA9O-06 2339489 2204472 skin NS NS NS malignant_melanoma NS NS NS y COSV51785510 COSM6957413 124947512 c.1102G>A p.D368N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 540 NS NS 73 ENSP00000413843.2:p.Asp368Asn ENST00000420316.6:c.1102G>A 7:g.55156628G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-81-5910-01 2120398 1994634 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 124950070 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 NS NS 64 ENSP00000413843.2:p.Arg252Cys ENST00000420316.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0001582-T01-IM3 2717588 2576409 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51769747 COSM297803 124959661 c.907G>C p.D303H Substitution - Missense het 38 7:55155847-55155847 + - PATHOGENIC .99461 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Asp303His ENST00000420316.6:c.907G>C 7:g.55155847G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S001092 1027684 944660 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2733978 2733978 2592705 soft_tissue fat NS NS liposarcoma NS NS NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 29731991 surgery-fixed recurrent ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 B42-S1 2732496 2591261 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV104576683 COSM9498592 124958374 c.958G>C p.E320Q Substitution - Missense 38 7:55155898-55155898 + - PATHOGENIC .98914 Confirmed somatic variant 29244145 surgery fresh/frozen primary 70.1 ENSP00000413843.2:p.Glu320Gln ENST00000420316.6:c.958G>C 7:g.55155898G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 DD282_Org 2749235 2607934 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51784286 COSM6652281 124950832 c.116C>T p.T39M Substitution - Missense het 38 7:55142313-55142313 + - PATHOGENIC .71105 Confirmed somatic variant 29703791 organoid culture primary 81 ENSP00000413843.2:p.Thr39Met ENST00000420316.6:c.116C>T 7:g.55142313C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 SJHGG029_R 2307362 2172566 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 24705251 surgery - NOS recurrent 4 ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 T1196 2658782 2518941 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51797600 COSM5575629 124956372 c.391G>A p.G131R Substitution - Missense 38 7:55143455-55143455 + - PATHOGENIC .99768 Confirmed somatic variant 27149842 NS NS 70.83 ENSP00000413843.2:p.Gly131Arg ENST00000420316.6:c.391G>A 7:g.55143455G>A DUSP8 ENST00000397374.7 1878 3074 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV104645104 COSM9385824 119273906 c.754C>T p.R252C Substitution - Missense 38 11:1557861-1557861 - - PATHOGENIC .93808 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000380530.3:p.Arg252Cys ENST00000397374.7:c.754C>T 11:g.1557861G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-CD-A4MI-01 2198040 2066318 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51771322 COSM3881814 124952969 c.1051A>G p.I351V Substitution - Missense 38 7:55156577-55156577 + - PATHOGENIC .89527 Confirmed somatic variant 541 NS NS 62 ENSP00000413843.2:p.Ile351Val ENST00000420316.6:c.1051A>G 7:g.55156577A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0008346-T01-IM5 2787024 2644447 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51838649 COSM6962468 124961900 c.412A>G p.R138G Substitution - Missense hom 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 30537512 surgery-fixed NS ENSP00000413843.2:p.Arg138Gly ENST00000420316.6:c.412A>G 7:g.55143476A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 ccRCC-90 1980826 1867072 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51815313 COSM1661639 124963096 c.673G>T p.G225C Substitution - Missense 38 7:55152590-55152590 + - PATHOGENIC .99717 Confirmed somatic variant 23797736 NS NS ENSP00000413843.2:p.Gly225Cys ENST00000420316.6:c.673G>T 7:g.55152590G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 CRC403 2730857 2589626 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105863818 COSM10064830 124952240 c.1061C>T p.T354M Substitution - Missense 38 7:55156587-55156587 + - PATHOGENIC .97048 Confirmed somatic variant 26416732 xenograft metastasis ENSP00000413843.2:p.Thr354Met ENST00000420316.6:c.1061C>T 7:g.55156587C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-12-0657-01 2178279 2046577 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99286086 COSM7481785 124962430 c.133G>A p.E45K Substitution - Missense 38 7:55142330-55142330 + - PATHOGENIC .99554 Confirmed somatic variant 329 NS NS 69 ENSP00000413843.2:p.Glu45Lys ENST00000420316.6:c.133G>A 7:g.55142330G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-DU-6410-01 2194391 2062669 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 56 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 PL9 2492972 2355586 breast NS NS NS carcinoma lobular_carcinoma pleomorphic NS y COSV105110769 COSM9569122 124967884 c.212A>C p.Q71P Substitution - Missense 38 7:55142409-55142409 + - PATHOGENIC .94041 Confirmed somatic variant 26907767 surgery fresh/frozen primary ENSP00000413843.2:p.Gln71Pro ENST00000420316.6:c.212A>C 7:g.55142409A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 W016-S1 2732510 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51785510 COSM6957413 124947512 c.1102G>A p.D368N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000413843.2:p.Asp368Asn ENST00000420316.6:c.1102G>A 7:g.55156628G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 W016-S1 2732510 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 EXTERN_MELA_20140524_012 2839317 2695083 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 124950328 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000413843.2:p.Ser116Phe ENST00000420316.6:c.347C>T 7:g.55143411C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 EXTERN_MELA_20140524_012 2839317 2695083 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51776559 COSM4892884 124950311 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 28467829 surgery fresh/frozen metastasis ENSP00000413843.2:p.Pro100Ser ENST00000420316.6:c.298C>T 7:g.55143362C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0006363-T01-IM5 2722740 2581561 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768139 COSM21685 124948622 c.866C>A p.A289D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000413843.2:p.Ala289Asp ENST00000420316.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0006363-T01-IM5 2722740 2581561 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T SCN2A_ENST00000283256 ENST00000283256.10 6018 10588 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105873046 COSM10012780 98564493 c.5288C>A p.S1763Y Substitution - Missense 38 2:165389094-165389094 + - PATHOGENIC .98186 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000283256.6:p.Ser1763Tyr ENST00000283256.10:c.5288C>A 2:g.165389094C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-YG-AA3N-01 2339750 2204733 skin NS NS NS malignant_melanoma NS NS NS y COSV51794869 COSM4362780 124948381 c.574C>T p.P192S Substitution - Missense 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 540 NS primary 67 ENSP00000413843.2:p.Pro192Ser ENST00000420316.6:c.574C>T 7:g.55151308C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0002022-T01-IM3 2718329 2577150 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 124950070 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg252Cys ENST00000420316.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2696712 2696712 2555616 oesophagus NS NS NS other metaplasia epidermoid NS n COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28731047 surgery-fixed primary 65 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 PT36 2521293 2383636 skin NS NS NS carcinoma basal_cell_carcinoma NS NS y COSV51784241 COSM5915646 124961835 c.1190C>T p.T397I Substitution - Missense 38 7:55156815-55156815 + - PATHOGENIC .99038 Confirmed somatic variant 25759019 surgery fresh/frozen NS ENSP00000413843.2:p.Thr397Ile ENST00000420316.6:c.1190C>T 7:g.55156815C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 16 2630307 2490691 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51780760 COSM6196858 124957487 c.341A>G p.E114G Substitution - Missense 38 7:55143405-55143405 + - PATHOGENIC .99844 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000413843.2:p.Glu114Gly ENST00000420316.6:c.341A>G 7:g.55143405A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0006368-T01-IM5 2722745 2581566 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51843325 COSM6950386 124960619 c.1102G>T p.D368Y Substitution - Missense het 38 7:55156628-55156628 + - PATHOGENIC .97349 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000413843.2:p.Asp368Tyr ENST00000420316.6:c.1102G>T 7:g.55156628G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-12-0691-01 2178100 2046398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774829 COSM1451549 124948462 c.767A>G p.D256G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 329 NS NS 63 ENSP00000413843.2:p.Asp256Gly ENST00000420316.6:c.767A>G 7:g.55154030A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0002105-T01-IM3 2718403 2577224 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51844520 COSM6920741 124957266 c.639C>G p.I213M Substitution - Missense het 38 7:55152556-55152556 + - PATHOGENIC .89498 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Ile213Met ENST00000420316.6:c.639C>G 7:g.55152556C>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0155 2107953 1985814 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 124949126 c.910C>T p.H304Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 23917401 NS NS ENSP00000413843.2:p.His304Tyr ENST00000420316.6:c.910C>T 7:g.55155850C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0000378-T01-IM3 2715158 2573979 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51849115 COSM6910123 124955459 c.715G>T p.G239C Substitution - Missense het 38 7:55152632-55152632 + - PATHOGENIC .99578 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Gly239Cys ENST00000420316.6:c.715G>T 7:g.55152632G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S001103 1027689 944665 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 124949356 c.787A>C p.T263P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000413843.2:p.Thr263Pro ENST00000420316.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 J11 2815385 2671765 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 29263181 surgery fresh/frozen NS 50 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0008601-T01-IM5 2724703 2583524 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 PDA_074 2367415 2230253 pancreas NS NS NS carcinoma ductal_carcinoma NS NS y COSV51828052 COSM5002066 124967960 c.514T>C p.F172L Substitution - Missense 38 7:55146695-55146695 + - NEUTRAL .04786 Confirmed somatic variant 25855536 NS NS ENSP00000413843.2:p.Phe172Leu ENST00000420316.6:c.514T>C 7:g.55146695T>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-32-1979-01 2120345 1994581 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 124949417 c.809A>G p.Y270C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 329 NS NS 69 ENSP00000413843.2:p.Tyr270Cys ENST00000420316.6:c.809A>G 7:g.55154072A>G ABCC8_ENST00000643260 ENST00000643260.1 4746 59 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105879570 COSM10012873 174469531 c.2054T>C p.F685S Substitution - Missense 38 11:17427926-17427926 - - PATHOGENIC .98111 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000494450.1:p.Phe685Ser ENST00000643260.1:c.2054T>C 11:g.17427926A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S001050 1027681 944657 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51835541 COSM21682 124962940 c.187G>C p.G63R Substitution - Missense het 38 7:55142384-55142384 + - PATHOGENIC .9897 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000413843.2:p.Gly63Arg ENST00000420316.6:c.187G>C 7:g.55142384G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S001050 1027681 944657 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51835525 COSM21681 124962935 c.136G>A p.D46N Substitution - Missense het 38 7:55142333-55142333 + - PATHOGENIC .94315 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000413843.2:p.Asp46Asn ENST00000420316.6:c.136G>A 7:g.55142333G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 CSCC-7-T 2292460 2158524 skin head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51852113 COSM4501266 124953499 c.584C>T p.P195L Substitution - Missense het 38 7:55151318-55151318 + - NEUTRAL .31382 Confirmed somatic variant 25303977 surgery fresh/frozen primary 60 ENSP00000413843.2:p.Pro195Leu ENST00000420316.6:c.584C>T 7:g.55151318C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 MB-T29 2802988 2659798 breast NS NS NS carcinoma ER-PR-positive_carcinoma NS NS n COSV51836185 COSM4884832 124959087 c.739G>T p.D247Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 26960396 fixed - NOS NS 83 ENSP00000413843.2:p.Asp247Tyr ENST00000420316.6:c.739G>T 7:g.55152656G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-14-1456-01 1338007 1248392 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 23 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0001193-T01-IM3 2716798 2575619 soft_tissue fibrous_tissue_and_uncertain_origin stomach NS gastrointestinal_stromal_tumour NS NS NS n COSV51852240 COSM6915314 124949794 c.332T>C p.M111T Substitution - Missense het 38 7:55143396-55143396 + - PATHOGENIC .8651 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Met111Thr ENST00000420316.6:c.332T>C 7:g.55143396T>C NBPF3 ENST00000318249.9 1902 25076 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV59056369 COSM4166741 106335576 c.1271T>G p.F424C Substitution - Missense 38 1:21480113-21480113 + - NEUTRAL .00026 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000316782.5:p.Phe424Cys ENST00000318249.9:c.1271T>G 1:g.21480113T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0008777-T01-IM5 2724826 2583647 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-92-6393-Tumor-SM-7CKB6 2640208 2500509 upper_aerodigestive_tract pharynx nasopharynx NS carcinoma nasopharyngeal_carcinoma NS NS y COSV51802220 COSM6458155 124948023 c.940G>A p.D314N Substitution - Missense 38 7:55155880-55155880 + - PATHOGENIC .94623 Confirmed somatic variant 28098136 surgery-fixed primary 65 ENSP00000413843.2:p.Asp314Asn ENST00000420316.6:c.940G>A 7:g.55155880G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-27-1838-01 1338063 1248448 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 124948622 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000413843.2:p.Ala289Asp ENST00000420316.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-1804-01 2120260 1994496 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51855357 COSM3412180 124963183 c.766G>T p.D256Y Substitution - Missense 38 7:55154029-55154029 + - PATHOGENIC .9742 Confirmed somatic variant 329 NS NS 81 ENSP00000413843.2:p.Asp256Tyr ENST00000420316.6:c.766G>T 7:g.55154029G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-14-0790-01 1337989 1248374 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 64 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-VQ-A8PX-01 2339506 2204489 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99285314 COSM8202780 124958660 c.671G>A p.R224H Substitution - Missense 38 7:55152588-55152588 + - PATHOGENIC .91275 Confirmed somatic variant 541 NS primary 51 ENSP00000413843.2:p.Arg224His ENST00000420316.6:c.671G>A 7:g.55152588G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV51830890 COSM3639718 124960976 c.303G>T p.L101F Substitution - Missense 38 7:55143367-55143367 + - PATHOGENIC .93362 Confirmed somatic variant 540 NS NS 37 ENSP00000413843.2:p.Leu101Phe ENST00000420316.6:c.303G>T 7:g.55143367G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-D3-A2JP-06 2121524 1995760 skin NS NS NS malignant_melanoma NS NS NS y COSV99293869 COSM8151148 124960991 c.1108C>A p.H370N Substitution - Missense 38 7:55156634-55156634 + - NEUTRAL .19929 Confirmed somatic variant 540 NS NS 37 ENSP00000413843.2:p.His370Asn ENST00000420316.6:c.1108C>A 7:g.55156634C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0001124-T01-IM3 2716673 2575494 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV51781531 COSM6914964 124955214 c.650A>T p.Q217L Substitution - Missense het 38 7:55152567-55152567 + - PATHOGENIC .9889 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Gln217Leu ENST00000420316.6:c.650A>T 7:g.55152567A>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0007562-T01-IM5 2723848 2582669 soft_tissue fibrous_tissue_and_uncertain_origin NS NS malignant_fibrous_histiocytoma-pleomorphic_sarcoma NS NS NS n COSV51779875 COSM6958517 124967314 c.922G>A p.V308I Substitution - Missense het 38 7:55155862-55155862 + - PATHOGENIC .99324 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Val308Ile ENST00000420316.6:c.922G>A 7:g.55155862G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2696516 2696516 2555420 central_nervous_system temporal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28201779 surgery fresh/frozen NS 68 ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0005929-T01-IM5 2722311 2581132 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-EE-A2MF-06 2339957 2204940 skin NS NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 124950328 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 540 NS NS 39 ENSP00000413843.2:p.Ser116Phe ENST00000420316.6:c.347C>T 7:g.55143411C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-EE-A2MF-06 2339957 2204940 skin NS NS NS malignant_melanoma NS NS NS y COSV51776559 COSM4892884 124950311 c.298C>T p.P100S Substitution - Missense 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 540 NS NS 39 ENSP00000413843.2:p.Pro100Ser ENST00000420316.6:c.298C>T 7:g.55143362C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GC13 2896794 2751142 placenta NS NS NS choriocarcinoma NS NS NS y COSV105863774 COSM9953649 124950664 c.446G>T p.R149L Substitution - Missense 38 7:55146627-55146627 + - PATHOGENIC .93954 Confirmed somatic variant 33319857 surgery-fixed metastasis 39 ENSP00000413843.2:p.Arg149Leu ENST00000420316.6:c.446G>T 7:g.55146627G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 T3110 2658365 2518524 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51837186 COSM1090861 124952337 c.442G>A p.V148M Substitution - Missense 38 7:55146623-55146623 + - PATHOGENIC .99004 Confirmed somatic variant 27149842 NS NS 60.33 ENSP00000413843.2:p.Val148Met ENST00000420316.6:c.442G>A 7:g.55146623G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-FP-A4BE-01 2197995 2066273 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51785413 COSM1176673 124950736 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 541 NS NS 55 ENSP00000413843.2:p.Arg252His ENST00000420316.6:c.755G>A 7:g.55154018G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-12-0656 2108024 1985885 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 124948622 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 23917401 NS NS ENSP00000413843.2:p.Ala289Asp ENST00000420316.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 600 2131840 2005904 upper_aerodigestive_tract mouth NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51777649 COSM3721610 124963379 c.608G>A p.G203E Substitution - Missense 38 7:55151342-55151342 + - PATHOGENIC .98938 Confirmed somatic variant 23619168 fresh/frozen - NOS NS 57 ENSP00000413843.2:p.Gly203Glu ENST00000420316.6:c.608G>A 7:g.55151342G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-76-6661-01 2120394 1994630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 124949126 c.910C>T p.H304Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 NS NS 54 ENSP00000413843.2:p.His304Tyr ENST00000420316.6:c.910C>T 7:g.55155850C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-76-6661-01 2120394 1994630 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51814881 COSM3929116 124955630 c.934G>T p.G312W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 329 NS NS 54 ENSP00000413843.2:p.Gly312Trp ENST00000420316.6:c.934G>T 7:g.55155874G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-CH-5765-01 1797170 1698917 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51795500 COSM1131544 124962323 c.692G>C p.C231S Substitution - Missense 38 7:55152609-55152609 + - PATHOGENIC .99547 Confirmed somatic variant 435 fresh/frozen - NOS primary 55 ENSP00000413843.2:p.Cys231Ser ENST00000420316.6:c.692G>C 7:g.55152609G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 IGC-04-1136 2662303 2522427 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51809481 COSM6530127 124953235 c.991G>C p.G331R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .97571 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000413843.2:p.Gly331Arg ENST00000420316.6:c.991G>C 7:g.55155931G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0000894-T01-IM3 2716206 2575027 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51822498 COSM3266565 124960202 c.917C>T p.S306L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Ser306Leu ENST00000420316.6:c.917C>T 7:g.55155857C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-12-0691 2108027 1985888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51774829 COSM1451549 124948462 c.767A>G p.D256G Substitution - Missense 38 7:55154030-55154030 + - PATHOGENIC .97996 Confirmed somatic variant 23917401 NS NS ENSP00000413843.2:p.Asp256Gly ENST00000420316.6:c.767A>G 7:g.55154030A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 Thyroid-CN-WZ037T 2635098 2495494 thyroid NS NS NS carcinoma NS NS NS y COSV51794993 COSM6399094 124954184 c.5G>A p.R2Q Substitution - Missense 38 7:55019282-55019282 + - NEUTRAL .46409 Confirmed somatic variant 676 NS primary 40 ENSP00000413843.2:p.Arg2Gln ENST00000420316.6:c.5G>A 7:g.55019282G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 SDC7 2564876 2426270 salivary_gland NS NS NS carcinoma salivary_duct_carcinoma NS NS y COSV51792147 COSM5988249 124957825 c.1170G>T p.Q390H Substitution - Missense 38 7:55156795-55156795 + - NEUTRAL .3446 Confirmed somatic variant 27103403 surgery fresh/frozen recurrent ENSP00000413843.2:p.Gln390His ENST00000420316.6:c.1170G>T 7:g.55156795G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 Br20P 1312980 1223889 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51815967 COSM39522 124948571 c.655T>G p.C219G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 18772396 surgery - NOS primary 77 ENSP00000413843.2:p.Cys219Gly ENST00000420316.6:c.655T>G 7:g.55152572T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009587-T01-IM5 2725481 2584302 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009587-T01-IM5 2725481 2584302 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0743-01 1337857 1248242 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 69 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0743-01 1337857 1248242 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51853321 COSM3412170 124960695 c.478G>A p.E160K Substitution - Missense 38 7:55146659-55146659 + - PATHOGENIC .9774 Confirmed somatic variant 329 surgery fresh/frozen NS 69 ENSP00000413843.2:p.Glu160Lys ENST00000420316.6:c.478G>A 7:g.55146659G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0002647-T01-IM3 2718893 2577714 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0881-01 1337868 1248253 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-14-1395-01 2120295 1994531 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51827895 COSM3412174 124949492 c.685A>T p.S229C Substitution - Missense 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 329 NS NS 52 ENSP00000413843.2:p.Ser229Cys ENST00000420316.6:c.685A>T 7:g.55152602A>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2876622 2876622 2731137 lung NS NS NS carcinoma NS NS NS n COSV51785510 COSM6957413 124947512 c.1102G>A p.D368N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 29506987 circulating tumour NS 51 ENSP00000413843.2:p.Asp368Asn ENST00000420316.6:c.1102G>A 7:g.55156628G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 T2946 2658354 2518513 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51777851 COSM1205052 124954369 c.494G>A p.R165Q Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .0375 Confirmed somatic variant 27149842 NS NS 78.66 ENSP00000413843.2:p.Arg165Gln ENST00000420316.6:c.494G>A 7:g.55146675G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 T3022 2658418 2518577 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51770269 COSM5710629 124960231 c.1015G>A p.G339R Substitution - Missense 38 7:55156541-55156541 + - PATHOGENIC .9949 Confirmed somatic variant 27149842 NS NS 74.83 ENSP00000413843.2:p.Gly339Arg ENST00000420316.6:c.1015G>A 7:g.55156541G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-E1-A7Z2-01 2457427 2320264 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 58 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0011383-T01-IM5 2726979 2585800 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 IGC-01-1037 2662275 2522399 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51838271 COSM6515024 124948780 c.125G>A p.G42D Substitution - Missense 38 7:55142322-55142322 + - PATHOGENIC .98106 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000413843.2:p.Gly42Asp ENST00000420316.6:c.125G>A 7:g.55142322G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783348 COSM6196859 124954169 c.380C>T p.A127V Substitution - Missense 38 7:55143444-55143444 + - NEUTRAL .27751 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000413843.2:p.Ala127Val ENST00000420316.6:c.380C>T 7:g.55143444C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 17 2630308 2490692 large_intestine colon left NS carcinoma adenocarcinoma NS NS n COSV51783354 COSM6196860 124954177 c.415A>G p.N139D Substitution - Missense 38 7:55143479-55143479 + - PATHOGENIC .81387 Confirmed somatic variant 27756406 surgery-fixed metastasis 51 ENSP00000413843.2:p.Asn139Asp ENST00000420316.6:c.415A>G 7:g.55143479A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009830-T01-IM5 2725668 2584489 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 124950736 c.755G>A p.R252H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Arg252His ENST00000420316.6:c.755G>A 7:g.55154018G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 Pat_41_B 2513797 2376166 NS NS NS NS malignant_melanoma NS NS NS y COSV51772860 COSM5872872 124961101 c.683C>T p.P228L Substitution - Missense 38 7:55152600-55152600 + - PATHOGENIC .99115 Confirmed somatic variant 24265153 surgery-fixed NS 76 ENSP00000413843.2:p.Pro228Leu ENST00000420316.6:c.683C>T 7:g.55152600C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-CV-7103-01 2193635 2061913 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99291703 COSM8371626 124961036 c.112C>G p.L38V Substitution - Missense 38 7:55142309-55142309 + - PATHOGENIC .94561 Confirmed somatic variant 627 NS NS 49 ENSP00000413843.2:p.Leu38Val ENST00000420316.6:c.112C>G 7:g.55142309C>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003702-T02-IM5 2720190 2579011 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51831642 COSM1496684 124952152 c.988G>A p.E330K Substitution - Missense het 38 7:55155928-55155928 + - PATHOGENIC .94538 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Glu330Lys ENST00000420316.6:c.988G>A 7:g.55155928G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GBM15 2144555 2013769 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 24285547 surgery fresh/frozen primary 73 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 MaPT05 2491636 2354277 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51771223 COSM3929114 124950425 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000413843.2:p.Glu84Val ENST00000420316.6:c.251A>T 7:g.55143315A>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-EY-A2OM-01 2198301 2066579 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99285698 COSM9064376 124952391 c.833A>G p.D278G Substitution - Missense 38 7:55154096-55154096 + - PATHOGENIC .95224 Confirmed somatic variant 419 NS NS 55 ENSP00000413843.2:p.Asp278Gly ENST00000420316.6:c.833A>G 7:g.55154096A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV104368998 COSM9232920 124953625 c.886C>T p.P296S Substitution - Missense het 38 7:55154149-55154149 + - PATHOGENIC .98876 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000413843.2:p.Pro296Ser ENST00000420316.6:c.886C>T 7:g.55154149C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2815634 2815634 2672014 stomach NS NS NS carcinoma mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable NS NS n COSV99294040 COSM9120802 124953605 c.379G>A p.A127T Substitution - Missense het 38 7:55143443-55143443 + - NEUTRAL .01752 Confirmed somatic variant 31620276 surgery-fixed NS 80 ENSP00000413843.2:p.Ala127Thr ENST00000420316.6:c.379G>A 7:g.55143443G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0001703-T01-IM3 2717826 2576647 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51782832 COSM3881808 124960282 c.739G>A p.D247N Substitution - Missense het 38 7:55152656-55152656 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Asp247Asn ENST00000420316.6:c.739G>A 7:g.55152656G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 92177 2807582 2664283 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99293495 COSM9130691 124969524 c.535G>A p.D179N Substitution - Missense 38 7:55146716-55146716 + - PATHOGENIC .99452 Confirmed somatic variant 24807215 surgery fresh/frozen primary 45 ENSP00000413843.2:p.Asp179Asn ENST00000420316.6:c.535G>A 7:g.55146716G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 T2250 2658595 2518754 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51769145 COSM3266559 124961080 c.874G>A p.V292M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 27149842 NS NS 62.08 ENSP00000413843.2:p.Val292Met ENST00000420316.6:c.874G>A 7:g.55154137G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 I2L-P16-Tumor-Biopsy 2433478 2296359 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51814923 COSM5358036 124949951 c.559T>C p.C187R Substitution - Missense het 38 7:55146740-55146740 + - PATHOGENIC .98691 Confirmed somatic variant 25957691 NS NS 67 ENSP00000413843.2:p.Cys187Arg ENST00000420316.6:c.559T>C 7:g.55146740T>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 MaPT01s 2491582 2354223 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51775191 COSM1451530 124948556 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000413843.2:p.Gly63Arg ENST00000420316.6:c.187G>A 7:g.55142384G>A SIGLECL1_ENST00000614422 ENST00000614422.4 594 26856 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105882075 COSM10012895 168965036 c.437C>T p.A146V Substitution - Missense 38 19:51267399-51267399 + - NEUTRAL .10189 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000480286.1:p.Ala146Val ENST00000614422.4:c.437C>T 19:g.51267399C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-14-1456 2108037 1985898 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 23917401 NS NS ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-5856-01 2120270 1994506 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 58 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-14-1823-01 1338013 1248398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 58 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A DCAF4_ENST00000553457 ENST00000553457.1 1002 20229 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105912372 COSM10012834 158819519 c.20G>A p.R7Q Substitution - Missense 38 14:72940346-72940346 + - NEUTRAL .14934 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000451186.1:p.Arg7Gln ENST00000553457.1:c.20G>A 14:g.72940346G>A DZANK1_ENST00000358866 ENST00000358866.10 2259 15858 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV52756978 COSM1024882 111744510 c.442C>T p.R148C Substitution - Missense 38 20:18453764-18453764 - - NEUTRAL .05574 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000351734.6:p.Arg148Cys ENST00000358866.10:c.442C>T 20:g.18453764G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P146 2072599 1951954 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 48 ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T WIPF3 ENST00000242140.9 1452 22004 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105840339 COSM10012942 98785876 c.286C>A p.P96T Substitution - Missense 38 7:29879071-29879071 + - PATHOGENIC .95711 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000242140.6:p.Pro96Thr ENST00000242140.9:c.286C>A 7:g.29879071C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-DF-A2KN-01 2457388 2320225 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99289848 COSM9047248 124952591 c.1058C>T p.A353V Substitution - Missense 38 7:55156584-55156584 + - PATHOGENIC .99015 Confirmed somatic variant 419 NS primary ENSP00000413843.2:p.Ala353Val ENST00000420316.6:c.1058C>T 7:g.55156584C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-FG-A70Z-01 2194226 2062504 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 53 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0002490-T01-IM3 2718762 2577583 NS NS NS NS malignant_melanoma NS NS NS n COSV51822498 COSM3266565 124960202 c.917C>T p.S306L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Ser306Leu ENST00000420316.6:c.917C>T 7:g.55155857C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0011389-T01-IM5 2726985 2585806 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GBM19-I3 2813467 2669859 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-FG-A4MW-01 2194412 2062690 central_nervous_system brain NS NS glioma NS NS NS y COSV51814881 COSM3929116 124955630 c.934G>T p.G312W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 545 NS NS 63 ENSP00000413843.2:p.Gly312Trp ENST00000420316.6:c.934G>T 7:g.55155874G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-02-2466-01 2178184 2046482 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 61 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T SCN2A_ENST00000631182 ENST00000631182.2 6018 10588 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105873046 COSM10012780 171846071 c.5288C>A p.S1763Y Substitution - Missense 38 2:165389094-165389094 + - PATHOGENIC .98186 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000486885.1:p.Ser1763Tyr ENST00000631182.2:c.5288C>A 2:g.165389094C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0008215-T01-IM5 2830122 2685937 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51834499 COSM6845063 124948074 c.964G>A p.G322S Substitution - Missense 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 30205045 surgery-fixed primary 58 ENSP00000413843.2:p.Gly322Ser ENST00000420316.6:c.964G>A 7:g.55155904G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-HT-8107-01 2194409 2062687 central_nervous_system brain NS NS glioma NS NS NS y COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 545 NS NS 62 ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S001076 1027683 944659 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 SA213 1659983 1574311 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS y COSV51858303 COSM214296 124965557 c.1159C>G p.L387V Substitution - Missense 38 7:55156784-55156784 + - PATHOGENIC .93843 Confirmed somatic variant 22495314 fresh/frozen - NOS primary 49 ENSP00000413843.2:p.Leu387Val ENST00000420316.6:c.1159C>G 7:g.55156784C>G L3MBTL1 ENST00000418998.5 2523 15905 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105927443 COSM10012772 125917977 c.1586G>A p.R529K Substitution - Missense 38 20:43534336-43534336 + - PATHOGENIC .99127 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000398516.1:p.Arg529Lys ENST00000418998.5:c.1586G>A 20:g.43534336G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0007084-T02-IM5 2723457 2582278 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51797839 COSM6958991 124960939 c.37G>A p.A13T Substitution - Missense het 38 7:55019314-55019314 + - NEUTRAL .01885 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Ala13Thr ENST00000420316.6:c.37G>A 7:g.55019314G>A TBC1D8 ENST00000409318.1 3468 17791 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105928021 COSM10012949 120715868 c.2455C>G p.R819G Substitution - Missense 38 2:101027448-101027448 - - PATHOGENIC .88528 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000386856.1:p.Arg819Gly ENST00000409318.1:c.2455C>G 2:g.101027448G>C WIPF3_ENST00000409123 ENST00000409123.5 1452 22004 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105840339 COSM10012942 123822247 c.286C>A p.P96T Substitution - Missense 38 7:29879071-29879071 + - PATHOGENIC .95711 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000386790.1:p.Pro96Thr ENST00000409123.5:c.286C>A 7:g.29879071C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 MaPT10 2491641 2354282 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS n COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 26832993 surgery-fixed NS ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-28-5207 2108065 1985926 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 23917401 NS NS ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-43-A56U-01 2195058 2063336 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99290842 COSM8713904 124968382 c.575C>G p.P192R Substitution - Missense 38 7:55151309-55151309 + - PATHOGENIC .9684 Confirmed somatic variant 418 NS NS 76 ENSP00000413843.2:p.Pro192Arg ENST00000420316.6:c.575C>G 7:g.55151309C>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 EXTERN_MELA_20140505_038 2839416 2695182 skin ear NS NS malignant_melanoma NS NS NS y COSV104577055 COSM9446911 124956859 c.887C>T p.P296L Substitution - Missense 38 7:55154150-55154150 + - PATHOGENIC .98876 Confirmed somatic variant 28467829 surgery fresh/frozen recurrent ENSP00000413843.2:p.Pro296Leu ENST00000420316.6:c.887C>T 7:g.55154150C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-02-2485-01 1337809 1248194 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 124948622 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 NS NS 53 ENSP00000413843.2:p.Ala289Asp ENST00000420316.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S001094 1027685 944661 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A CSMD3 ENST00000297405.9 11124 19291 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105903899 COSM10012835 102291655 c.8940T>A p.N2980K Substitution - Missense 38 8:112291544-112291544 - - PATHOGENIC .90952 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000297405.5:p.Asn2980Lys ENST00000297405.9:c.8940T>A 8:g.112291544A>T MYF6 ENST00000228641.3 729 7566 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105849048 COSM10012852 101153430 c.191C>A p.A64E Substitution - Missense 38 12:80707910-80707910 + - PATHOGENIC .99078 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000228641.3:p.Ala64Glu ENST00000228641.3:c.191C>A 12:g.80707910C>A WSCD1_ENST00000317744 ENST00000317744.9 1728 29060 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV58497674 COSM4749261 105724276 c.695G>A p.R232H Substitution - Missense 38 17:6090473-6090473 + - PATHOGENIC .71202 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000323087.5:p.Arg232His ENST00000317744.9:c.695G>A 17:g.6090473G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009873-T01-IM5 2725712 2584533 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-76-6656-01 2120392 1994628 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51857475 COSM3412176 124963131 c.719G>A p.C240Y Substitution - Missense 38 7:55152636-55152636 + - PATHOGENIC .99504 Confirmed somatic variant 329 NS NS 66 ENSP00000413843.2:p.Cys240Tyr ENST00000420316.6:c.719G>A 7:g.55152636G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 7T 2473854 2336624 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51797600 COSM5575629 124956372 c.391G>A p.G131R Substitution - Missense 38 7:55143455-55143455 + - PATHOGENIC .99768 Confirmed somatic variant 26489445 fixed - NOS NS ENSP00000413843.2:p.Gly131Arg ENST00000420316.6:c.391G>A 7:g.55143455G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 DUMC-05 2748702 2607405 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 29802247 surgery fresh/frozen NS 51 ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-81-5911-01 2120399 1994635 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 33 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-14-0866-01 2178121 2046419 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99295486 COSM7482458 124956933 c.1139C>T p.S380F Substitution - Missense 38 7:55156764-55156764 + - NEUTRAL .25937 Confirmed somatic variant 329 NS NS 55 ENSP00000413843.2:p.Ser380Phe ENST00000420316.6:c.1139C>T 7:g.55156764C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 OSCC-GB_00550111 2340760 2205743 upper_aerodigestive_tract mouth NS NS carcinoma NS NS NS y COSV51836185 COSM4884832 124959087 c.739G>T p.D247Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 539 NS primary 58 ENSP00000413843.2:p.Asp247Tyr ENST00000420316.6:c.739G>T 7:g.55152656G>T MAF ENST00000326043.4 1212 6776 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105884268 COSM10012914 103795990 c.1008G>T p.R336S Substitution - Missense 38 16:79598895-79598895 - - PATHOGENIC .96375 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000327048.4:p.Arg336Ser ENST00000326043.4:c.1008G>T 16:g.79598895C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0011540-T01-IM5 2727112 2585933 small_intestine ileum NS NS carcinoma adenocarcinoma NS NS n COSV51797215 COSM145360 124951679 c.967G>A p.V323I Substitution - Missense het 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Val323Ile ENST00000420316.6:c.967G>A 7:g.55155907G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 XHDG25 2306032 2171303 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV51811244 COSM4767521 124949336 c.607G>A p.G203R Substitution - Missense 38 7:55151341-55151341 + - PATHOGENIC .99471 Confirmed somatic variant 24997986 NS NS ENSP00000413843.2:p.Gly203Arg ENST00000420316.6:c.607G>A 7:g.55151341G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2665864 2665864 2525572 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792237 COSM6842523 124951652 c.829_830delinsGA p.M277E Substitution - Missense het 38 7:55154092-55154093 + - Confirmed somatic variant 28979142 surgery - NOS NS 70 ENSP00000413843.2:p.Met277Glu ENST00000420316.6:c.829_830delinsGA 7:g.55154092_55154093delinsGA CSMD3 ENST00000297405.9 11124 19291 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105904311 COSM10012881 102354508 c.7865C>A p.A2622E Substitution - Missense 38 8:112310998-112310998 - - PATHOGENIC .97269 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000297405.5:p.Ala2622Glu ENST00000297405.9:c.7865C>A 8:g.112310998G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 R056-I1 2813481 2669873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289246 COSM8268187 124949177 c.788C>T p.T263I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 28263318 surgery fresh/frozen NS 42 ENSP00000413843.2:p.Thr263Ile ENST00000420316.6:c.788C>T 7:g.55154051C>T FRY_ENST00000642040 ENST00000642040.1 9051 20367 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105932591 COSM10012802 176341484 c.1969G>A p.D657N Substitution - Missense 38 13:32171088-32171088 + - PATHOGENIC .96279 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000493189.1:p.Asp657Asn ENST00000642040.1:c.1969G>A 13:g.32171088G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 T578 2658233 2518392 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51788796 COSM4680390 124956395 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 27149842 NS NS 61.08 ENSP00000413843.2:p.Arg98Gln ENST00000420316.6:c.293G>A 7:g.55143357G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 10677523 2751151 2609847 lung NS NS NS carcinoma small_cell_carcinoma NS NS n COSV105822269 COSM9522392 124955521 c.1006G>C p.V336L Substitution - Missense 38 7:55155946-55155946 + - Confirmed somatic variant 29748005 circulating tumour NS ENSP00000413843.2:p.Val336Leu ENST00000420316.6:c.1006G>C 7:g.55155946G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0002999-T01-IM3 2783044 2640827 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 124950736 c.755G>A p.R252H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28825054 surgery-fixed primary 57 ENSP00000413843.2:p.Arg252His ENST00000420316.6:c.755G>A 7:g.55154018G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 618 1630888 1547758 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma NS NS y COSV51797215 COSM145360 124951679 c.967G>A p.V323I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 22158541 blood-bone marrow NS ENSP00000413843.2:p.Val323Ile ENST00000420316.6:c.967G>A 7:g.55155907G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-13-0912-01 1474988 1398687 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51781835 COSM174732 124949519 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 331 NS primary 58 ENSP00000413843.2:p.Glu114Lys ENST00000420316.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-13-0912-01 1474988 1398687 ovary NS NS NS carcinoma serous_carcinoma NS NS y COSV51781835 COSM174732 124949519 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 21720365 331 NS primary 58 ENSP00000413843.2:p.Glu114Lys ENST00000420316.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-CV-6961-01 2193755 2062033 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51839851 COSM7340115 124957750 c.1118C>A p.P373Q Substitution - Missense 38 7:55156644-55156644 + - PATHOGENIC .76649 Confirmed somatic variant 627 NS NS 61 ENSP00000413843.2:p.Pro373Gln ENST00000420316.6:c.1118C>A 7:g.55156644C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 3101B7_035_T 2390296 2253128 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51811266 COSM5041204 124958744 c.385A>G p.K129E Substitution - Missense 38 7:55143449-55143449 + - PATHOGENIC .9498 Confirmed somatic variant 25159915 NS NS ENSP00000413843.2:p.Lys129Glu ENST00000420316.6:c.385A>G 7:g.55143449A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0749 2107988 1985849 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 23917401 NS NS ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003783-T01-IM5 2720274 2579095 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0007319-T01-IM5 2723658 2582479 penis NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51785510 COSM6957413 124947512 c.1102G>A p.D368N Substitution - Missense het 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Asp368Asn ENST00000420316.6:c.1102G>A 7:g.55156628G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-BR-8680-01 2197966 2066244 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51785413 COSM1176673 124950736 c.755G>A p.R252H Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 541 NS NS 45 ENSP00000413843.2:p.Arg252His ENST00000420316.6:c.755G>A 7:g.55154018G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 124949356 c.787A>C p.T263P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Thr263Pro ENST00000420316.6:c.787A>C 7:g.55154050A>C TTN_ENST00000615779 ENST00000615779.5 103053 12403 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV59957361 COSM130006 168040954 c.184C>T p.R62C Substitution - Missense 38 2:178802249-178802249 - - PATHOGENIC .99021 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000483597.1:p.Arg62Cys ENST00000615779.5:c.184C>T 2:g.178802249G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 T578 2296255 2161858 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51788796 COSM4680390 124956395 c.293G>A p.R98Q Substitution - Missense 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 25344691 NS NS 61.08 ENSP00000413843.2:p.Arg98Gln ENST00000420316.6:c.293G>A 7:g.55143357G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003108-T01-IM5 2719604 2578425 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51866279 COSM6926300 124949157 c.665G>A p.R222H Substitution - Missense het 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000413843.2:p.Arg222His ENST00000420316.6:c.665G>A 7:g.55152582G>A SMOX ENST00000621355.4 1758 15862 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105846220 COSM10009557 168856320 c.841C>T p.R281W Substitution - Missense 38 20:4182320-4182320 + - .51649 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000478305.1:p.Arg281Trp ENST00000621355.4:c.841C>T 20:g.4182320C>T FCGR3A_ENST00000443193 ENST00000443193.5 765 3619 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV63460316 COSM4224348 126637535 c.254G>T p.G85V Substitution - Missense 38 1:161548486-161548486 - - .64272 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000392047.2:p.Gly85Val ENST00000443193.5:c.254G>T 1:g.161548486C>A OR52K2 ENST00000325719.4 945 15223 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV57834639 COSM1979383 103506668 c.607G>A p.A203T Substitution - Missense 38 11:4449946-4449946 + - NEUTRAL .10397 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000318956.4:p.Ala203Thr ENST00000325719.4:c.607G>A 11:g.4449946G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801732 COSM3923812 124965631 c.1091C>T p.S364F Substitution - Missense 38 7:55156617-55156617 + - NEUTRAL .433 Confirmed somatic variant 540 NS NS 68 ENSP00000413843.2:p.Ser364Phe ENST00000420316.6:c.1091C>T 7:g.55156617C>T VCP ENST00000358901.10 2421 12666 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105913370 COSM10012904 111837789 c.727C>T p.L243F Substitution - Missense 38 9:35063062-35063062 - - PATHOGENIC .96421 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000351777.6:p.Leu243Phe ENST00000358901.10:c.727C>T 9:g.35063062G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0876 2107991 1985852 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 23917401 NS NS ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A OR56A1_ENST00000641938 ENST00000641938.1 945 14781 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105883756 COSM10012845 175775449 c.755T>G p.L252R Substitution - Missense 38 11:6026938-6026938 - - NEUTRAL .24245 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000493321.1:p.Leu252Arg ENST00000641938.1:c.755T>G 11:g.6026938A>C TTN_ENST00000615779 ENST00000615779.5 103053 12403 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105912072 COSM10012820 167974997 c.9543A>T p.K3181N Substitution - Missense 38 2:178766541-178766541 - - PATHOGENIC .90433 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000483597.1:p.Lys3181Asn ENST00000615779.5:c.9543A>T 2:g.178766541T>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-28-1749-01 2178174 2046472 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 124952264 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 NS NS 73 ENSP00000413843.2:p.Thr363Ile ENST00000420316.6:c.1088C>T 7:g.55156614C>T FCGR3A_ENST00000436743 ENST00000436743.5 765 3619 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV63460316 COSM4224348 130098171 c.254G>T p.G85V Substitution - Missense 38 1:161548486-161548486 - - .64272 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000416607.1:p.Gly85Val ENST00000436743.5:c.254G>T 1:g.161548486C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2492703 2492703 2355318 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 124956593 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000413843.2:p.His47Tyr ENST00000420316.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 16668 1423695 1333723 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51790297 COSM48317 124966791 c.406C>A p.P136T Substitution - Missense het 38 7:55143470-55143470 + - PATHOGENIC .9933 Confirmed somatic variant 18948947 surgery fresh/frozen primary ENSP00000413843.2:p.Pro136Thr ENST00000420316.6:c.406C>A 7:g.55143470C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 MELA_34952 2760718 2619251 skin head_neck NS NS malignant_melanoma superficial_spreading NS NS y COSV51785510 COSM6957413 124947512 c.1102G>A p.D368N Substitution - Missense 38 7:55156628-55156628 + - PATHOGENIC .92673 Confirmed somatic variant 30178487 surgery fresh/frozen metastasis 25 ENSP00000413843.2:p.Asp368Asn ENST00000420316.6:c.1102G>A 7:g.55156628G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-32-1970-01 1338089 1248474 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 1194732 1194732 1106627 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T CSMD3_ENST00000343508 ENST00000343508.7 11004 19291 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105903899 COSM10012835 107882568 c.8820T>A p.N2940K Substitution - Missense 38 8:112291544-112291544 - - PATHOGENIC .90952 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000345799.3:p.Asn2940Lys ENST00000343508.7:c.8820T>A 8:g.112291544A>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0001819-T01-IM3 2718053 2576874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T CSMD3_ENST00000343508 ENST00000343508.7 11004 19291 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105904311 COSM10012881 107933733 c.7745C>A p.A2582E Substitution - Missense 38 8:112310998-112310998 - - PATHOGENIC .97269 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000345799.3:p.Ala2582Glu ENST00000343508.7:c.7745C>A 8:g.112310998G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0006713-T01-IM5 2723092 2581913 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51784387 COSM6953025 124968579 c.70G>T p.A24S Substitution - Missense het 38 7:55019347-55019347 + - NEUTRAL .37583 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Ala24Ser ENST00000420316.6:c.70G>T 7:g.55019347G>T HMGB1_ENST00000399494 ENST00000399494.5 648 4983 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV58104601 COSM3813701 121408921 c.630A>T p.E210D Substitution - Missense 38 13:30461375-30461375 - - .57857 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000382417.1:p.Glu210Asp ENST00000399494.5:c.630A>T 13:g.30461375T>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 CRC65 2730847 2589616 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS y COSV105863705 COSM10062224 124947602 c.193T>G p.L65V Substitution - Missense 38 7:55142390-55142390 + - PATHOGENIC .83273 Confirmed somatic variant 26416732 xenograft metastasis 45 ENSP00000413843.2:p.Leu65Val ENST00000420316.6:c.193T>G 7:g.55142390T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 5-WS012-T2 2869948 2724945 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110279 COSM9809368 124970873 c.299C>T p.P100L Substitution - Missense 38 7:55143363-55143363 + - PATHOGENIC .96024 Confirmed somatic variant 26950094 surgery - NOS NS 82 ENSP00000413843.2:p.Pro100Leu ENST00000420316.6:c.299C>T 7:g.55143363C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-FR-A726-01 2197831 2066109 skin NS NS NS malignant_melanoma NS NS NS y COSV51778830 COSM1698691 124949405 c.1198G>A p.E400K Substitution - Missense 38 7:55156823-55156823 + - PATHOGENIC .99571 Confirmed somatic variant 540 NS NS 90 ENSP00000413843.2:p.Glu400Lys ENST00000420316.6:c.1198G>A 7:g.55156823G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 Br112X 1313001 1223910 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 18772396 xenograft primary 48 ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 R056-I1 2813481 2669873 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 42 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-DK-AA75-01 2385754 2248586 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51771467 COSM7104388 124953339 c.1077C>A p.F359L Substitution - Missense 38 7:55156603-55156603 + - PATHOGENIC .96682 Confirmed somatic variant 413 NS primary 82 ENSP00000413843.2:p.Phe359Leu ENST00000420316.6:c.1077C>A 7:g.55156603C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 OSCC-GB_00130111 2121052 1995288 upper_aerodigestive_tract mouth NS NS carcinoma NS NS NS y COSV51815394 COSM3715755 124951042 c.738C>A p.S246R Substitution - Missense 38 7:55152655-55152655 + - NEUTRAL .15461 Confirmed somatic variant 539 NS NS ENSP00000413843.2:p.Ser246Arg ENST00000420316.6:c.738C>A 7:g.55152655C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0001278-T01-IM3 2716974 2575795 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51844468 COSM6916179 124955732 c.308A>T p.N103I Substitution - Missense het 38 7:55143372-55143372 + - PATHOGENIC .97828 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Asn103Ile ENST00000420316.6:c.308A>T 7:g.55143372A>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0008215-T01-IM5 2724369 2583190 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51834499 COSM6845063 124948074 c.964G>A p.G322S Substitution - Missense het 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Gly322Ser ENST00000420316.6:c.964G>A 7:g.55155904G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 Br229T 1313048 1223957 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51848573 COSM39565 124959998 c.931T>A p.C311S Substitution - Missense het 38 7:55155871-55155871 + - PATHOGENIC .98855 Confirmed somatic variant 18772396 surgery - NOS primary 28 ENSP00000413843.2:p.Cys311Ser ENST00000420316.6:c.931T>A 7:g.55155871T>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 W016-S2 2732511 2591268 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 29244145 surgery fresh/frozen primary 56 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0008346-T01-IM5 2724474 2583295 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51838649 COSM6962468 124961900 c.412A>G p.R138G Substitution - Missense het 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg138Gly ENST00000420316.6:c.412A>G 7:g.55143476A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-E5-A2PC-01 1898110 1786794 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51779680 COSM1313184 124958328 c.1151C>G p.T384S Substitution - Missense 38 7:55156776-55156776 + - PATHOGENIC .98418 Confirmed somatic variant 413 fresh/frozen - NOS primary 61 ENSP00000413843.2:p.Thr384Ser ENST00000420316.6:c.1151C>G 7:g.55156776C>G OR5D14 ENST00000335605.1 945 15281 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105902571 COSM10012795 104061594 c.879C>A p.S293R Substitution - Missense 38 11:55796434-55796434 + - NEUTRAL .1178 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000334456.1:p.Ser293Arg ENST00000335605.1:c.879C>A 11:g.55796434C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51781835 COSM174732 124949519 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Glu114Lys ENST00000420316.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787534 COSM6191454 124948365 c.1075T>C p.F359L Substitution - Missense 38 7:55156601-55156601 + - PATHOGENIC .99231 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000413843.2:p.Phe359Leu ENST00000420316.6:c.1075T>C 7:g.55156601T>C TMEM132D ENST00000422113.6 3300 29411 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV70605139 COSM1578873 124923374 c.472G>A p.D158N Substitution - Missense 38 12:129700306-129700306 - - PATHOGENIC .93797 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000408581.2:p.Asp158Asn ENST00000422113.6:c.472G>A 12:g.129700306C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 HUB-02-B2-042 2607096 2466810 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51802097 COSM6047686 124966572 c.299C>A p.P100H Substitution - Missense 38 7:55143363-55143363 + - PATHOGENIC .9585 Confirmed somatic variant 670 organoid culture NS ENSP00000413843.2:p.Pro100His ENST00000420316.6:c.299C>A 7:g.55143363C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-14-1034-02 2120293 1994529 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51775191 COSM1451530 124948556 c.187G>A p.G63R Substitution - Missense 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 329 NS NS 60 ENSP00000413843.2:p.Gly63Arg ENST00000420316.6:c.187G>A 7:g.55142384G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009852-T01-IM5 2725690 2584511 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51768139 COSM21685 124948622 c.866C>A p.A289D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Asp ENST00000420316.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2014_Lung_sq_15_T 2744886 2603589 lung NS NS NS carcinoma NS NS NS y COSV51805367 COSM3950642 124958783 c.1039G>A p.D347N Substitution - Missense 38 7:55156565-55156565 + - PATHOGENIC .82248 Confirmed somatic variant 583 NS primary 72 ENSP00000413843.2:p.Asp347Asn ENST00000420316.6:c.1039G>A 7:g.55156565G>A SIGLECL1_ENST00000597824 ENST00000597824.1 312 26856 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105882075 COSM10012895 166397419 c.155C>T p.A52V Substitution - Missense 38 19:51267399-51267399 + - NEUTRAL .10189 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000472702.1:p.Ala52Val ENST00000597824.1:c.155C>T 19:g.51267399C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 SK01600_P 1951898 1838690 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51835132 COSM1600351 124963677 c.977G>C p.C326S Substitution - Missense het 38 7:55155917-55155917 + - PATHOGENIC .99486 Confirmed somatic variant 23441165 surgery - NOS primary 57 ENSP00000413843.2:p.Cys326Ser ENST00000420316.6:c.977G>C 7:g.55155917G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 PD6511a 1491955 1415113 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_unilineage_dysplasia refractory_anaemia n COSV51792673 COSM4384113 124963767 c.523A>G p.N175D Substitution - Missense 38 7:55146704-55146704 + - PATHOGENIC .986 Confirmed somatic variant 24030381 NS NS ENSP00000413843.2:p.Asn175Asp ENST00000420316.6:c.523A>G 7:g.55146704A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-27-2528-01 1338071 1248456 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 surgery fresh/frozen NS 62 ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 B72-S1 2732506 2591266 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 124952264 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 29244145 surgery fresh/frozen primary 76.6 ENSP00000413843.2:p.Thr363Ile ENST00000420316.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003679-T01-IM5 2720169 2578990 stomach gastroesophageal_junction NS NS carcinoma adenocarcinoma NS NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0006612-T01-IM5 2722991 2581812 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51843352 COSM6950555 124960642 c.530C>T p.S177L Substitution - Missense het 38 7:55146711-55146711 + - NEUTRAL .28714 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ser177Leu ENST00000420316.6:c.530C>T 7:g.55146711C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-28-1752-01 2178270 2046568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 42 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 EXTERN_MELA_20140924_001 2839320 2695086 skin lower_leg NS NS malignant_melanoma NS NS NS y COSV51781835 COSM174732 124949519 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28467829 cell-line metastasis ENSP00000413843.2:p.Glu114Lys ENST00000420316.6:c.340G>A 7:g.55143404G>A IFT22_ENST00000517481 ENST00000517481.5 327 21895 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105876048 COSM10012944 146418050 c.16G>A p.G6R Substitution - Missense 38 7:101316502-101316502 - - PATHOGENIC .98716 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000429202.1:p.Gly6Arg ENST00000517481.5:c.16G>A 7:g.101316502C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-FW-A3R5-06 2185962 2054259 skin NS NS NS malignant_melanoma NS NS NS y COSV51801711 COSM3923810 124965624 c.907G>A p.D303N Substitution - Missense 38 7:55155847-55155847 + - PATHOGENIC .99324 Confirmed somatic variant 540 NS NS 68 ENSP00000413843.2:p.Asp303Asn ENST00000420316.6:c.907G>A 7:g.55155847G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-28-1752-01 2178270 2046568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 42 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-27-1831-01 1338056 1248441 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 66 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51865345 COSM6970489 124969891 c.1177G>A p.D393N Substitution - Missense het 38 7:55156802-55156802 + - PATHOGENIC .91392 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Asp393Asn ENST00000420316.6:c.1177G>A 7:g.55156802G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-OL-A5RZ-01 2187696 2055974 breast NS NS NS carcinoma NS NS NS y COSV99288978 COSM7695792 124955044 c.289G>C p.E97Q Substitution - Missense 38 7:55143353-55143353 + - PATHOGENIC .94007 Confirmed somatic variant 414 NS NS 57 ENSP00000413843.2:p.Glu97Gln ENST00000420316.6:c.289G>C 7:g.55143353G>C MAF_ENST00000393350 ENST00000393350.1 1122 6776 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105884268 COSM10012914 118534282 c.1008G>T p.R336S Substitution - Missense 38 16:79598895-79598895 - - PATHOGENIC .96375 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000377019.1:p.Arg336Ser ENST00000393350.1:c.1008G>T 16:g.79598895C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003108-T01-IM5 2829558 2685373 breast NS NS NS carcinoma lobular_carcinoma NS NS n COSV51866279 COSM6926300 124949157 c.665G>A p.R222H Substitution - Missense 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 30205045 surgery-fixed metastasis 37 ENSP00000413843.2:p.Arg222His ENST00000420316.6:c.665G>A 7:g.55152582G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-KK-A59Y-01 2340238 2205221 prostate NS NS NS carcinoma adenocarcinoma NS NS y COSV51814881 COSM3929116 124955630 c.934G>T p.G312W Substitution - Missense 38 7:55155874-55155874 + - NEUTRAL .42686 Confirmed somatic variant 435 NS primary 56 ENSP00000413843.2:p.Gly312Trp ENST00000420316.6:c.934G>T 7:g.55155874G>T KCND3 ENST00000315987.6 1968 6239 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105875997 COSM10012826 104238386 c.740C>T p.A247V Substitution - Missense 38 1:111981987-111981987 - - PATHOGENIC .96322 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000319591.2:p.Ala247Val ENST00000315987.6:c.740C>T 1:g.111981987G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0007897-T01-IM5 2724108 2582929 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense het 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-DU-A7TD-01 2339610 2204593 central_nervous_system brain NS NS glioma NS NS NS y COSV99294781 COSM8258176 124966102 c.827A>T p.Q276L Substitution - Missense 38 7:55154090-55154090 + - PATHOGENIC .97144 Confirmed somatic variant 545 NS primary 52 ENSP00000413843.2:p.Gln276Leu ENST00000420316.6:c.827A>T 7:g.55154090A>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 J80_T 2194988 2063266 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51805367 COSM3950642 124958783 c.1039G>A p.D347N Substitution - Missense 38 7:55156565-55156565 + - PATHOGENIC .82248 Confirmed somatic variant 583 NS NS ENSP00000413843.2:p.Asp347Asn ENST00000420316.6:c.1039G>A 7:g.55156565G>A PTPDC1_ENST00000288976 ENST00000288976.3 2421 30184 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105860297 COSM10012886 102172285 c.554C>T p.P185L Substitution - Missense 38 9:94088207-94088207 + - PATHOGENIC .9798 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000288976.3:p.Pro185Leu ENST00000288976.3:c.554C>T 9:g.94088207C>T ADAM18 ENST00000265707.9 2220 196 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV105848019 COSM10012907 97549871 c.1154C>A p.P385Q Substitution - Missense 38 8:39648451-39648451 + - NEUTRAL .02606 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000265707.5:p.Pro385Gln ENST00000265707.9:c.1154C>A 8:g.39648451C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009752-T01-IM5 2725621 2584442 skin NS NS NS malignant_melanoma NS NS NS n COSV51865283 COSM6970485 124969848 c.188G>A p.G63E Substitution - Missense het 38 7:55142385-55142385 + - PATHOGENIC .95671 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Gly63Glu ENST00000420316.6:c.188G>A 7:g.55142385G>A VPS33B_ENST00000535906 ENST00000535906.1 1773 12712 P1_Pre-RAFi_EGFRi 2907493 2761702 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV60980714 COSM5633052 155099266 c.581G>A p.R194Q Substitution - Missense 38 15:91006988-91006988 - - PATHOGENIC .91655 Confirmed somatic variant 25673644 surgery-fixed metastasis ENSP00000444053.1:p.Arg194Gln ENST00000535906.1:c.581G>A 15:g.91006988C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0142-01 2120247 1994483 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 81 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 1194726 1194726 1106621 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-S9-A7IX-01 2263383 2130367 central_nervous_system brain NS NS glioma NS NS NS y COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 545 NS primary 57 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 LC_C30 1863711 1754602 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 22975805 surgery fresh/frozen primary 38 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 LICA-CN-HCC055T 2634102 2494498 liver NS NS NS other neoplasm NS NS y COSV51829036 COSM5823994 124956719 c.1001G>C p.R334P Substitution - Missense 38 7:55155941-55155941 + - PATHOGENIC .84442 Confirmed somatic variant 660 NS primary 65 ENSP00000413843.2:p.Arg334Pro ENST00000420316.6:c.1001G>C 7:g.55155941G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0004944-T02-IM5 2721354 2580175 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51843300 COSM6949613 124960593 c.937G>T p.A313S Substitution - Missense het 38 7:55155877-55155877 + - NEUTRAL .06397 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000413843.2:p.Ala313Ser ENST00000420316.6:c.937G>T 7:g.55155877G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0002999-T01-IM3 2719208 2578029 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51785413 COSM1176673 124950736 c.755G>A p.R252H Substitution - Missense het 38 7:55154018-55154018 + - PATHOGENIC .84433 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg252His ENST00000420316.6:c.755G>A 7:g.55154018G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-HT-8110-01 2194393 2062671 central_nervous_system brain NS NS glioma NS NS NS y COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 545 NS NS 57 ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 Br215T 1313044 1223953 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51785554 COSM21688 124947980 c.971G>T p.R324L Substitution - Missense het 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 18772396 surgery - NOS primary 50 ENSP00000413843.2:p.Arg324Leu ENST00000420316.6:c.971G>T 7:g.55155911G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-B5-A11E-01 1783399 1687398 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99287802 COSM9037443 124965939 c.529T>C p.S177P Substitution - Missense 38 7:55146710-55146710 + - NEUTRAL .17589 Confirmed somatic variant 419 fresh/frozen - NOS primary 53 ENSP00000413843.2:p.Ser177Pro ENST00000420316.6:c.529T>C 7:g.55146710T>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 Br124X 1313013 1223922 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 xenograft primary 44 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2625914 2625914 2486326 large_intestine colon descending NS carcinoma adenocarcinoma NS NS n COSV51787547 COSM6191455 124948371 c.1126T>C p.F376L Substitution - Missense 38 7:55156652-55156652 + - PATHOGENIC .98052 Confirmed somatic variant 25617745 surgery-fixed NS 23 ENSP00000413843.2:p.Phe376Leu ENST00000420316.6:c.1126T>C 7:g.55156652T>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 T1849 2658271 2518430 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51794620 COSM6652251 124965498 c.46G>A p.A16T Substitution - Missense 38 7:55019323-55019323 + - NEUTRAL .21777 Confirmed somatic variant 27149842 NS NS 79.25 ENSP00000413843.2:p.Ala16Thr ENST00000420316.6:c.46G>A 7:g.55019323G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0155-01 1337821 1248206 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 124949126 c.910C>T p.H304Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 surgery fresh/frozen NS 61 ENSP00000413843.2:p.His304Tyr ENST00000420316.6:c.910C>T 7:g.55155850C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-2557-01 1337877 1248262 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 76 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0006124-T01-IM5 2722503 2581324 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51842040 COSM6948138 124961865 c.1077C>G p.F359L Substitution - Missense het 38 7:55156603-55156603 + - PATHOGENIC .96894 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000413843.2:p.Phe359Leu ENST00000420316.6:c.1077C>G 7:g.55156603C>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0007813-T01-IM5 2724038 2582859 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767730 COSM6548312 124950391 c.662G>T p.G221V Substitution - Missense het 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 28481359 fixed - NOS metastasis ENSP00000413843.2:p.Gly221Val ENST00000420316.6:c.662G>T 7:g.55152579G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-DU-A5TT-01 2194423 2062701 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS NS 70 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-AM-5821-01 1651151 1565938 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV99291226 COSM7552389 124957914 c.1124C>T p.A375V Substitution - Missense 38 7:55156650-55156650 + - PATHOGENIC .98971 Confirmed somatic variant 376 NS NS 68 ENSP00000413843.2:p.Ala375Val ENST00000420316.6:c.1124C>T 7:g.55156650C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-DU-7006-01 2194244 2062522 central_nervous_system brain NS NS glioma NS NS NS y COSV51800797 COSM3412178 124951443 c.755G>C p.R252P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 545 NS NS 60 ENSP00000413843.2:p.Arg252Pro ENST00000420316.6:c.755G>C 7:g.55154018G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 1022 2491916 2354545 breast NS NS NS fibroepithelial_neoplasm phyllodes_tumour malignant NS y COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 26437033 surgery fresh/frozen NS 55 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 PCA0136 2580109 2441446 prostate NS NS NS carcinoma adenocarcinoma NS NS n COSV51788967 COSM6005513 124963406 c.446G>A p.R149Q Substitution - Missense 38 7:55146627-55146627 + - PATHOGENIC .75281 Confirmed somatic variant 20579941 surgery fresh/frozen primary 54 ENSP00000413843.2:p.Arg149Gln ENST00000420316.6:c.446G>A 7:g.55146627G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 019T 2067099 1946896 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51840438 COSM1727959 124954530 c.374A>G p.Y125C Substitution - Missense 38 7:55143438-55143438 + - PATHOGENIC .99088 Confirmed somatic variant 23788652 surgery - NOS primary ENSP00000413843.2:p.Tyr125Cys ENST00000420316.6:c.374A>G 7:g.55143438A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-28-5207-01 2120332 1994568 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 71 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0004400-T01-IM5 2720811 2579632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0005127-T01-IM5 2721532 2580353 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51802355 COSM6941144 124948406 c.1154C>T p.P385L Substitution - Missense het 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000413843.2:p.Pro385Leu ENST00000420316.6:c.1154C>T 7:g.55156779C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 Br140X 1313029 1223938 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 xenograft primary 41 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P147 2072600 1951955 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 44 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0001328-T01-IM3 2717084 2575905 lung NS NS NS carcinoma large_cell_neuroendocrine_carcinoma NS NS n COSV51833335 COSM6916442 124953021 c.14G>C p.G5A Substitution - Missense het 38 7:55019291-55019291 + - NEUTRAL .0753 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Gly5Ala ENST00000420316.6:c.14G>C 7:g.55019291G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-2565-01 1337884 1248269 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 59 ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 SC-her2-051 2313868 2179064 breast NS NS NS carcinoma ER-positive_carcinoma NS NS n COSV51850832 COSM4943273 124970280 c.840C>A p.N280K Substitution - Missense 38 7:55154103-55154103 + - PATHOGENIC .93631 Confirmed somatic variant 24185512 surgery fresh/frozen metastasis ENSP00000413843.2:p.Asn280Lys ENST00000420316.6:c.840C>A 7:g.55154103C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-BH-A18U-01 1899961 1788645 breast NS NS NS carcinoma NS NS NS y COSV99294745 COSM7670588 124961142 c.769G>A p.E257K Substitution - Missense 38 7:55154032-55154032 + - PATHOGENIC .97243 Confirmed somatic variant 414 fresh/frozen - NOS primary 72 ENSP00000413843.2:p.Glu257Lys ENST00000420316.6:c.769G>A 7:g.55154032G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 CGCRC167 2434467 2297344 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV105863924 COSM10049276 124955410 c.1040A>T p.D347V Substitution - Missense 38 7:55156566-55156566 + - PATHOGENIC .89104 Confirmed somatic variant 26416732 surgery - NOS primary 81 ENSP00000413843.2:p.Asp347Val ENST00000420316.6:c.1040A>T 7:g.55156566A>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0006441-T01-IM5 2722817 2581638 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51775191 COSM1451530 124948556 c.187G>A p.G63R Substitution - Missense het 38 7:55142384-55142384 + - PATHOGENIC .9814 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Gly63Arg ENST00000420316.6:c.187G>A 7:g.55142384G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 1461 2602435 2463311 large_intestine right NS NS carcinoma adenocarcinoma NS NS n COSV51813913 COSM6023901 124950656 c.344A>C p.N115T Substitution - Missense 38 7:55143408-55143408 + - PATHOGENIC .92454 Confirmed somatic variant 27121310 surgery fresh/frozen NS 47 ENSP00000413843.2:p.Asn115Thr ENST00000420316.6:c.344A>C 7:g.55143408A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-12-0707-01 2178095 2046393 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51781245 COSM3412184 124949417 c.809A>G p.Y270C Substitution - Missense 38 7:55154072-55154072 + - PATHOGENIC .99273 Confirmed somatic variant 329 NS NS 55 ENSP00000413843.2:p.Tyr270Cys ENST00000420316.6:c.809A>G 7:g.55154072A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-19-5956-01 2178192 2046490 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99292946 COSM7469776 124965665 c.461C>A p.P154H Substitution - Missense 38 7:55146642-55146642 + - PATHOGENIC .80234 Confirmed somatic variant 329 NS NS 53 ENSP00000413843.2:p.Pro154His ENST00000420316.6:c.461C>A 7:g.55146642C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 14_S4 2902121 2756359 autonomic_ganglia NS NS NS neuroblastoma NS NS NS n COSV105863896 COSM9976114 124954709 c.818C>G p.T273S Substitution - Missense 38 7:55154081-55154081 + - PATHOGENIC .94747 Confirmed somatic variant 33381456 circulating tumour primary 7 ENSP00000413843.2:p.Thr273Ser ENST00000420316.6:c.818C>G 7:g.55154081C>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-D7-6521-01 2198059 2066337 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51778897 COSM3881800 124966849 c.253G>A p.V85M Substitution - Missense 38 7:55143317-55143317 + - PATHOGENIC .99051 Confirmed somatic variant 541 NS NS 65 ENSP00000413843.2:p.Val85Met ENST00000420316.6:c.253G>A 7:g.55143317G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0002659-T01-IM3 2718905 2577726 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51775381 COSM6923532 124964345 c.1049C>G p.S350C Substitution - Missense het 38 7:55156575-55156575 + - PATHOGENIC .99062 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Ser350Cys ENST00000420316.6:c.1049C>G 7:g.55156575C>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-14-1455-01 2178074 2046372 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 124952264 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 NS NS 61 ENSP00000413843.2:p.Thr363Ile ENST00000420316.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0008450-T01-IM5 2724567 2583388 skin NS NS NS malignant_melanoma NS NS NS n COSV51822498 COSM3266565 124960202 c.917C>T p.S306L Substitution - Missense het 38 7:55155857-55155857 + - PATHOGENIC .98807 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ser306Leu ENST00000420316.6:c.917C>T 7:g.55155857C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-14-1829-01 1338016 1248401 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 124952264 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 329 surgery fresh/frozen NS 57 ENSP00000413843.2:p.Thr363Ile ENST00000420316.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0007504-T01-IM5 2723789 2582610 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2815636 2815636 2672016 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV104369000 COSM9233361 124960107 c.352G>T p.A118S Substitution - Missense het 38 7:55143416-55143416 + - PATHOGENIC .99878 Confirmed somatic variant 31620276 surgery-fixed NS 71 ENSP00000413843.2:p.Ala118Ser ENST00000420316.6:c.352G>T 7:g.55143416G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0649-01 1337849 1248234 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51791901 COSM2151461 124961325 c.991G>A p.G331R Substitution - Missense 38 7:55155931-55155931 + - PATHOGENIC .96902 Confirmed somatic variant 329 surgery fresh/frozen NS 73 ENSP00000413843.2:p.Gly331Arg ENST00000420316.6:c.991G>A 7:g.55155931G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 124948622 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000413843.2:p.Ala289Asp ENST00000420316.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0011544-T01-IM5 2727116 2585937 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51774354 COSM6981709 124969915 c.951G>C p.E317D Substitution - Missense het 38 7:55155891-55155891 + - PATHOGENIC .93673 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Glu317Asp ENST00000420316.6:c.951G>C 7:g.55155891G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0004400-T01-IM5 2720811 2579632 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0005725-T01-IM5 2722109 2580930 NS NS NS NS malignant_melanoma NS NS NS n COSV51776559 COSM4892884 124950311 c.298C>T p.P100S Substitution - Missense het 38 7:55143362-55143362 + - PATHOGENIC .99092 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000413843.2:p.Pro100Ser ENST00000420316.6:c.298C>T 7:g.55143362C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0876-01 1337864 1248249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-12-3650-01 2120284 1994520 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS NS 46 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-14-0786-01 1337986 1248371 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 surgery fresh/frozen NS 50 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0008927-T01-IM5 2724943 2583764 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51768139 COSM21685 124948622 c.866C>A p.A289D Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Asp ENST00000420316.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0004688-T01-IM5 2721089 2579910 urinary_tract upper_urinary_tract NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51823965 COSM6937748 124957569 c.76G>A p.E26K Substitution - Missense het 38 7:55019353-55019353 + - PATHOGENIC .70393 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000413843.2:p.Glu26Lys ENST00000420316.6:c.76G>A 7:g.55019353G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 LICA-CN-HCC131T 2634178 2494574 liver NS NS NS other neoplasm NS NS y COSV51799496 COSM5824594 124957595 c.244A>T p.I82F Substitution - Missense 38 7:55143308-55143308 + - PATHOGENIC .99415 Confirmed somatic variant 660 NS primary 49 ENSP00000413843.2:p.Ile82Phe ENST00000420316.6:c.244A>T 7:g.55143308A>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 XHDG25C 2321255 2186409 biliary_tract gallbladder NS NS carcinoma adenocarcinoma NS NS y COSV51811244 COSM4767521 124949336 c.607G>A p.G203R Substitution - Missense 38 7:55151341-55151341 + - PATHOGENIC .99471 Confirmed somatic variant 24997986 NS NS 77 ENSP00000413843.2:p.Gly203Arg ENST00000420316.6:c.607G>A 7:g.55151341G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2876654 2876654 2731169 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 circulating tumour NS 63 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-14-1455 2108036 1985897 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51779091 COSM2155593 124952264 c.1088C>T p.T363I Substitution - Missense 38 7:55156614-55156614 + - PATHOGENIC .99308 Confirmed somatic variant 23917401 NS NS ENSP00000413843.2:p.Thr363Ile ENST00000420316.6:c.1088C>T 7:g.55156614C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S001073 1027682 944658 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 s_DS_scb_02_tumour 2861572 2716810 urinary_tract bladder NS NS carcinoma small_cell_carcinoma NS NS n COSV105109947 COSM9575249 124955371 c.673G>A p.G225S Substitution - Missense 38 7:55152590-55152590 + - PATHOGENIC .99676 Confirmed somatic variant 29180607 surgery-fixed NS 68 ENSP00000413843.2:p.Gly225Ser ENST00000420316.6:c.673G>A 7:g.55152590G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0004837-T01-IM5 2721240 2580061 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51812540 COSM1451536 124954910 c.322A>G p.R108G Substitution - Missense het 38 7:55143386-55143386 + - PATHOGENIC .72671 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000413843.2:p.Arg108Gly ENST00000420316.6:c.322A>G 7:g.55143386A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0000785-T01-IM3 2715984 2574805 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51767730 COSM6548312 124950391 c.662G>T p.G221V Substitution - Missense het 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Gly221Val ENST00000420316.6:c.662G>T 7:g.55152579G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 R074-R1 2813496 2669888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99297135 COSM9212199 124954770 c.865G>T p.A289S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 41 ENSP00000413843.2:p.Ala289Ser ENST00000420316.6:c.865G>T 7:g.55154128G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0005127-T01-IM5 2721532 2580353 NS NS NS NS carcinoma of_unknown_primary NS NS n COSV51794869 COSM4362780 124948381 c.574C>T p.P192S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000413843.2:p.Pro192Ser ENST00000420316.6:c.574C>T 7:g.55151308C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-AX-A06F-01 2198328 2066606 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS y COSV99294241 COSM8943299 124961378 c.710C>A p.A237D Substitution - Missense 38 7:55152627-55152627 + - PATHOGENIC .99353 Confirmed somatic variant 419 NS NS 59 ENSP00000413843.2:p.Ala237Asp ENST00000420316.6:c.710C>A 7:g.55152627C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-BA-6872-01 2193616 2061894 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99294544 COSM8387616 124954990 c.571G>A p.D191N Substitution - Missense 38 7:55151305-55151305 + - PATHOGENIC .93234 Confirmed somatic variant 627 NS NS 47 ENSP00000413843.2:p.Asp191Asn ENST00000420316.6:c.571G>A 7:g.55151305G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 IGC-10-1053 2662337 2522461 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51767730 COSM6548312 124950391 c.662G>T p.G221V Substitution - Missense 38 7:55152579-55152579 + - .66073 Confirmed somatic variant 27923066 surgery fresh/frozen primary ENSP00000413843.2:p.Gly221Val ENST00000420316.6:c.662G>T 7:g.55152579G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 96737 1973055 1859299 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSV51777851 COSM1205052 124954369 c.494G>A p.R165Q Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .0375 Confirmed somatic variant 23680147 surgery - NOS primary ENSP00000413843.2:p.Arg165Gln ENST00000420316.6:c.494G>A 7:g.55146675G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 587342 1766789 1671109 large_intestine colon NS NS carcinoma adenocarcinoma NS NS y COSV51777851 COSM1205052 124954369 c.494G>A p.R165Q Substitution - Missense 38 7:55146675-55146675 + - NEUTRAL .0375 Confirmed somatic variant 22895193 surgery fresh/frozen primary ENSP00000413843.2:p.Arg165Gln ENST00000420316.6:c.494G>A 7:g.55146675G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0004837-T01-IM5 2721240 2580061 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-2563-01 1337882 1248267 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 124950070 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 329 surgery fresh/frozen NS 72 ENSP00000413843.2:p.Arg252Cys ENST00000420316.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-28-1757-01 2178083 2046381 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 71 ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0005378-T01-IM5 2721782 2580603 pancreas NS NS NS carcinoma ductal_carcinoma NS NS n COSV51862161 COSM6943352 124947488 c.73C>G p.L25V Substitution - Missense het 38 7:55019350-55019350 + - NEUTRAL .21138 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000413843.2:p.Leu25Val ENST00000420316.6:c.73C>G 7:g.55019350C>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009459-T01-IM5 2725386 2584207 testis NS NS NS germ_cell_tumour mixed NS NS n COSV51822613 COSM6968786 124952197 c.92G>T p.C31F Substitution - Missense het 38 7:55142289-55142289 + - PATHOGENIC .99814 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Cys31Phe ENST00000420316.6:c.92G>T 7:g.55142289G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-EE-A2M7-06 2121673 1995909 skin NS NS NS malignant_melanoma NS NS NS y COSV51790699 COSM3639729 124956535 c.791G>A p.C264Y Substitution - Missense 38 7:55154054-55154054 + - PATHOGENIC .99369 Confirmed somatic variant 540 NS NS 66 ENSP00000413843.2:p.Cys264Tyr ENST00000420316.6:c.791G>A 7:g.55154054G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-2561-01 1337880 1248265 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51841003 COSM3412168 124966956 c.445C>T p.R149W Substitution - Missense 38 7:55146626-55146626 + - PATHOGENIC .93775 Confirmed somatic variant 329 surgery fresh/frozen NS 53 ENSP00000413843.2:p.Arg149Trp ENST00000420316.6:c.445C>T 7:g.55146626C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-FR-A8YC-06 2263445 2130429 skin NS NS NS malignant_melanoma NS NS NS y COSV51772860 COSM5872872 124961101 c.683C>T p.P228L Substitution - Missense 38 7:55152600-55152600 + - PATHOGENIC .99115 Confirmed somatic variant 540 NS NS 78 ENSP00000413843.2:p.Pro228Leu ENST00000420316.6:c.683C>T 7:g.55152600C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0006437-T01-IM5 2722813 2581634 skin NS NS NS adnexal_tumour malignant_adnexal_tumour NS NS n COSV51788796 COSM4680390 124956395 c.293G>A p.R98Q Substitution - Missense het 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg98Gln ENST00000420316.6:c.293G>A 7:g.55143357G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2492701 2492701 2355316 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 124956593 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen metastasis ENSP00000413843.2:p.His47Tyr ENST00000420316.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0001248-T01-IM3 2716920 2575741 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51855488 COSM4166393 124952901 c.710C>T p.A237V Substitution - Missense het 38 7:55152627-55152627 + - PATHOGENIC .99229 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Ala237Val ENST00000420316.6:c.710C>T 7:g.55152627C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003350-T01-IM5 2719841 2578662 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51815967 COSM39522 124948571 c.655T>G p.C219G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Cys219Gly ENST00000420316.6:c.655T>G 7:g.55152572T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 YUKLAB 2013569 1896201 skin NS NS NS malignant_melanoma NS NS NS y COSV51796177 COSM1698689 124962388 c.1189A>T p.T397S Substitution - Missense het 38 7:55156814-55156814 + - PATHOGENIC .9893 Confirmed somatic variant 22842228 surgery fresh/frozen metastasis 84 ENSP00000413843.2:p.Thr397Ser ENST00000420316.6:c.1189A>T 7:g.55156814A>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 19T 2745856 2604559 liver NS NS NS other neoplasm NS NS y COSV51840438 COSM1727959 124954530 c.374A>G p.Y125C Substitution - Missense 38 7:55143438-55143438 + - PATHOGENIC .99088 Confirmed somatic variant 660 NS primary 71 ENSP00000413843.2:p.Tyr125Cys ENST00000420316.6:c.374A>G 7:g.55143438A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2625883 2625883 2486295 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS n COSV51796371 COSM6191453 124967179 c.203C>T p.T68I Substitution - Missense 38 7:55142400-55142400 + - PATHOGENIC .99116 Confirmed somatic variant 25617745 surgery-fixed NS 61 ENSP00000413843.2:p.Thr68Ile ENST00000420316.6:c.203C>T 7:g.55142400C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0010967-T01-IM5 2726608 2585429 endometrium NS NS NS carcinoma endometrioid_carcinoma NS NS n COSV51856949 COSM6978220 124970203 c.413G>T p.R138I Substitution - Missense het 38 7:55143477-55143477 + - PATHOGENIC .94211 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg138Ile ENST00000420316.6:c.413G>T 7:g.55143477G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GBM7-I1 2813443 2669835 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 R056-R1 2813482 2669874 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99289246 COSM8268187 124949177 c.788C>T p.T263I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 42 ENSP00000413843.2:p.Thr263Ile ENST00000420316.6:c.788C>T 7:g.55154051C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0005370-T01-IM5 2721774 2580595 skin NS NS NS malignant_melanoma NS NS NS n COSV51794869 COSM4362780 124948381 c.574C>T p.P192S Substitution - Missense het 38 7:55151308-55151308 + - PATHOGENIC .78298 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000413843.2:p.Pro192Ser ENST00000420316.6:c.574C>T 7:g.55151308C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-EA-A410-01 2262924 2129908 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51769145 COSM3266559 124961080 c.874G>A p.V292M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 415 NS primary 51 ENSP00000413843.2:p.Val292Met ENST00000420316.6:c.874G>A 7:g.55154137G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 Br306T 1313064 1223973 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 18772396 surgery - NOS primary 51 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 171T 2473937 2336707 stomach NS NS NS carcinoma adenocarcinoma NS NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 26489445 fixed - NOS NS ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0010130-T01-IM5 2725937 2584758 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51788796 COSM4680390 124956395 c.293G>A p.R98Q Substitution - Missense het 38 7:55143357-55143357 + - NEUTRAL .05967 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Arg98Gln ENST00000420316.6:c.293G>A 7:g.55143357G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-12-0670-01 2178104 2046402 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 124949356 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 NS NS 60 ENSP00000413843.2:p.Thr263Pro ENST00000420316.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 98019 1520664 1443039 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51786915 COSM94179 124951992 c.610G>A p.E204K Substitution - Missense 38 7:55151344-55151344 + - NEUTRAL .0681 Confirmed somatic variant 20668451 NS primary ENSP00000413843.2:p.Glu204Lys ENST00000420316.6:c.610G>A 7:g.55151344G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0007018-T01-IM5 2723393 2582214 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765787 COSM2149971 124949126 c.910C>T p.H304Y Substitution - Missense het 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.His304Tyr ENST00000420316.6:c.910C>T 7:g.55155850C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003393-T01-IM5 2829603 2685418 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51792310 COSM6928197 124950409 c.50C>T p.A17V Substitution - Missense 38 7:55019327-55019327 + - NEUTRAL .01177 Confirmed somatic variant 30205045 surgery-fixed metastasis 43 ENSP00000413843.2:p.Ala17Val ENST00000420316.6:c.50C>T 7:g.55019327C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 123 2748095 2606798 stomach NS NS NS carcinoma NS NS NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 683 NS primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GBM7-I2 2813444 2669836 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 69 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-EE-A17X-06 2121618 1995854 skin NS NS NS malignant_melanoma NS NS NS y COSV51781835 COSM174732 124949519 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 540 NS NS 54 ENSP00000413843.2:p.Glu114Lys ENST00000420316.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0008262-T01-IM5 2724401 2583222 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0008346-T01-IM5 2830127 2685942 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51838649 COSM6962468 124961900 c.412A>G p.R138G Substitution - Missense 38 7:55143476-55143476 + - PATHOGENIC .87497 Confirmed somatic variant 30205045 surgery-fixed primary 61 ENSP00000413843.2:p.Arg138Gly ENST00000420316.6:c.412A>G 7:g.55143476A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 CHC1774T 2340683 2205666 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51807517 COSM4802395 124964552 c.67C>T p.R23W Substitution - Missense 38 7:55019344-55019344 + - NEUTRAL .00803 Confirmed somatic variant 381 NS primary 65 ENSP00000413843.2:p.Arg23Trp ENST00000420316.6:c.67C>T 7:g.55019344C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0006119-T01-IM5 2722498 2581319 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51836484 COSM6948259 124968462 c.857G>A p.S286N Substitution - Missense het 38 7:55154120-55154120 + - PATHOGENIC .95351 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000413843.2:p.Ser286Asn ENST00000420316.6:c.857G>A 7:g.55154120G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 ATL020 2488648 2351297 haematopoietic_and_lymphoid_tissue NS NS NS lymphoid_neoplasm adult_T_cell_lymphoma-leukaemia NS NS y COSV51770269 COSM5710629 124960231 c.1015G>A p.G339R Substitution - Missense 38 7:55156541-55156541 + - PATHOGENIC .9949 Confirmed somatic variant 26437031 NS NS 63 ENSP00000413843.2:p.Gly339Arg ENST00000420316.6:c.1015G>A 7:g.55156541G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S10-24679-TP 2366580 2229463 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51808100 COSM4992964 124968935 c.818C>T p.T273I Substitution - Missense het 38 7:55154081-55154081 + - PATHOGENIC .9224 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000413843.2:p.Thr273Ile ENST00000420316.6:c.818C>T 7:g.55154081C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-BR-4256-01 2198141 2066419 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV51797215 COSM145360 124951679 c.967G>A p.V323I Substitution - Missense 38 7:55155907-55155907 + - PATHOGENIC .80847 Confirmed somatic variant 541 NS NS 80 ENSP00000413843.2:p.Val323Ile ENST00000420316.6:c.967G>A 7:g.55155907G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2772383 2772383 2630573 breast NS NS NS carcinoma basal_(triple-negative)_carcinoma NS NS n COSV99290341 COSM7347800 124965548 c.1016G>A p.G339E Substitution - Missense 38 7:55156542-55156542 + - PATHOGENIC .99668 Confirmed somatic variant 29807833 circulating tumour NS ENSP00000413843.2:p.Gly339Glu ENST00000420316.6:c.1016G>A 7:g.55156542G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-AR-A2LR-01 2187807 2056085 breast NS NS NS carcinoma NS NS NS y COSV51781835 COSM174732 124949519 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 414 NS NS 49 ENSP00000413843.2:p.Glu114Lys ENST00000420316.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0006119-T01-IM5 2722498 2581319 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51836444 COSM6948255 124968436 c.496G>A p.D166N Substitution - Missense het 38 7:55146677-55146677 + - PATHOGENIC .99816 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000413843.2:p.Asp166Asn ENST00000420316.6:c.496G>A 7:g.55146677G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0007994-T01-IM5 2724178 2582999 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS n COSV51811471 COSM6960839 124961884 c.380C>A p.A127E Substitution - Missense het 38 7:55143444-55143444 + - NEUTRAL .44126 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Ala127Glu ENST00000420316.6:c.380C>A 7:g.55143444C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-32-1991-01 2120347 1994583 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 NS NS 60 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-12-0670 2108025 1985886 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 124949356 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 23917401 NS NS ENSP00000413843.2:p.Thr263Pro ENST00000420316.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 R074-R1 2813496 2669888 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen recurrent 41 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 18195 2422953 2285875 urinary_tract bladder NS NS carcinoma transitional_cell_carcinoma NS NS y COSV51779680 COSM1313184 124958328 c.1151C>G p.T384S Substitution - Missense 38 7:55156776-55156776 + - PATHOGENIC .98418 Confirmed somatic variant 24469795 NS NS 61 ENSP00000413843.2:p.Thr384Ser ENST00000420316.6:c.1151C>G 7:g.55156776C>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-CV-7252-01 2193523 2061801 upper_aerodigestive_tract head_neck NS NS carcinoma squamous_cell_carcinoma NS NS y COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 627 NS NS 62 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0008927-T01-IM5 2724943 2583764 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS n COSV51767495 COSM35752 124950070 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg252Cys ENST00000420316.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 YUSCO 2013686 1896318 skin NS NS NS malignant_melanoma NS NS NS y COSV51778830 COSM1698691 124949405 c.1198G>A p.E400K Substitution - Missense het 38 7:55156823-55156823 + - PATHOGENIC .99571 Confirmed somatic variant 22842228 NS NS ENSP00000413843.2:p.Glu400Lys ENST00000420316.6:c.1198G>A 7:g.55156823G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003393-T01-IM5 2719877 2578698 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51792310 COSM6928197 124950409 c.50C>T p.A17V Substitution - Missense het 38 7:55019327-55019327 + - NEUTRAL .01177 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Ala17Val ENST00000420316.6:c.50C>T 7:g.55019327C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GBM12 2144553 2013767 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 24285547 surgery fresh/frozen primary 64 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 pfg043T 2309624 2174826 stomach NS NS NS carcinoma intestinal_adenocarcinoma NS NS y COSV51790826 COSM4755611 124949444 c.566A>C p.K189T Substitution - Missense het 38 7:55151300-55151300 + - PATHOGENIC .93585 Confirmed somatic variant 24816253 surgery fresh/frozen NS 76 ENSP00000413843.2:p.Lys189Thr ENST00000420316.6:c.566A>C 7:g.55151300A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 MELA_20076 2760731 2619264 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 124949843 c.1168C>A p.Q390K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 30178487 surgery fresh/frozen metastasis 30 ENSP00000413843.2:p.Gln390Lys ENST00000420316.6:c.1168C>A 7:g.55156793C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-EE-A3AB-06 2121693 1995929 skin NS NS NS malignant_melanoma NS NS NS y COSV51828861 COSM3639735 124949843 c.1168C>A p.Q390K Substitution - Missense 38 7:55156793-55156793 + - NEUTRAL .03793 Confirmed somatic variant 540 NS NS 30 ENSP00000413843.2:p.Gln390Lys ENST00000420316.6:c.1168C>A 7:g.55156793C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009711-T01-IM5 2725587 2584408 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0006054-T01-IM5 2722434 2581255 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 88 2630342 2490726 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51769145 COSM3266559 124961080 c.874G>A p.V292M Substitution - Missense 38 7:55154137-55154137 + - PATHOGENIC .98723 Confirmed somatic variant 27756406 surgery-fixed primary 48 ENSP00000413843.2:p.Val292Met ENST00000420316.6:c.874G>A 7:g.55154137G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-AA-3982-01 1651089 1565876 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51769747 COSM297803 124959661 c.907G>C p.D303H Substitution - Missense 38 7:55155847-55155847 + - PATHOGENIC .99461 Confirmed somatic variant 22810696 376 NS NS 75 ENSP00000413843.2:p.Asp303His ENST00000420316.6:c.907G>C 7:g.55155847G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-RD-A7BT-01 2263044 2130028 stomach NS NS NS carcinoma adenocarcinoma NS NS y COSV99295752 COSM8178996 124956989 c.715G>A p.G239S Substitution - Missense 38 7:55152632-55152632 + - PATHOGENIC .99504 Confirmed somatic variant 541 NS primary 66 ENSP00000413843.2:p.Gly239Ser ENST00000420316.6:c.715G>A 7:g.55152632G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0005051-T01-IM5 2721455 2580276 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery - NOS primary ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 1194723 1194723 1106618 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51853292 COSM29339 124965285 c.271A>C p.I91L Substitution - Missense 38 7:55143335-55143335 + - PATHOGENIC .99037 Confirmed somatic variant 19284481 surgery fresh/frozen primary ENSP00000413843.2:p.Ile91Leu ENST00000420316.6:c.271A>C 7:g.55143335A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0013704-T01-IM5 2803863 2660613 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51781835 COSM174732 124949519 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 29316426 surgery-fixed primary 71 ENSP00000413843.2:p.Glu114Lys ENST00000420316.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-71-8520-01 2194759 2063037 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 417 NS NS 60 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-2563 2108004 1985865 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51767495 COSM35752 124950070 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 23917401 NS NS ENSP00000413843.2:p.Arg252Cys ENST00000420316.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-OL-A97C-01 2386126 2248958 breast NS NS NS carcinoma NS NS NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 414 NS primary 67 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 SF268 1998472 1883544 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 23856246 cell-line primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0016773-T01-IM6 2830871 2686686 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV104577017 COSM9359622 124954718 c.743G>A p.C248Y Substitution - Missense 38 7:55152660-55152660 + - PATHOGENIC .99504 Confirmed somatic variant 30205045 surgery-fixed primary 77 ENSP00000413843.2:p.Cys248Tyr ENST00000420316.6:c.743G>A 7:g.55152660G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 PD6780a 1503990 1426868 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia_with_ringed_sideroblasts NS n COSV51791654 COSM4384111 124961463 c.95A>G p.Q32R Substitution - Missense 38 7:55142292-55142292 + - PATHOGENIC .96882 Confirmed somatic variant 24030381 NS NS ENSP00000413843.2:p.Gln32Arg ENST00000420316.6:c.95A>G 7:g.55142292A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2876604 2876604 2731119 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 29506987 circulating tumour NS 55 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009661-T01-IM5 2725553 2584374 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-DU-7292-01 2194421 2062699 central_nervous_system brain NS NS glioma NS NS NS y COSV51800797 COSM3412178 124951443 c.755G>C p.R252P Substitution - Missense 38 7:55154018-55154018 + - PATHOGENIC .90984 Confirmed somatic variant 545 NS NS 69 ENSP00000413843.2:p.Arg252Pro ENST00000420316.6:c.755G>C 7:g.55154018G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 PD6883a 1504094 1426972 haematopoietic_and_lymphoid_tissue NS NS NS haematopoietic_neoplasm myelodysplastic_syndrome refractory_cytopenia_with_multilinear_dysplasia NS n COSV51850592 COSM4384117 124951404 c.754C>G p.R252G Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .93941 Confirmed somatic variant 24030381 NS NS ENSP00000413843.2:p.Arg252Gly ENST00000420316.6:c.754C>G 7:g.55154017C>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 APGI-AMP-2890 2866039 2721116 pancreas ampulla_of_Vater NS NS carcinoma ductal_carcinoma NS NS y COSV105111099 COSM9620623 124963519 c.661G>A p.G221R Substitution - Missense 38 7:55152578-55152578 + - NEUTRAL .36671 Confirmed somatic variant 26804919 surgery fresh/frozen NS ENSP00000413843.2:p.Gly221Arg ENST00000420316.6:c.661G>A 7:g.55152578G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003417-T01-IM5 2719901 2578722 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS n COSV51815967 COSM39522 124948571 c.655T>G p.C219G Substitution - Missense het 38 7:55152572-55152572 + - PATHOGENIC .99532 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Cys219Gly ENST00000420316.6:c.655T>G 7:g.55152572T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2696517 2696517 2555421 central_nervous_system frontal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense hom 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28201779 surgery fresh/frozen NS 60 ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0158-01 1910185 1798476 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 329 fresh/frozen - NOS primary 74 ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-VS-A9UA-01 2386196 2249028 cervix NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99290048 COSM8641365 124961672 c.528G>C p.M176I Substitution - Missense 38 7:55146709-55146709 + - NEUTRAL .34467 Confirmed somatic variant 415 NS primary 60 ENSP00000413843.2:p.Met176Ile ENST00000420316.6:c.528G>C 7:g.55146709G>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 5-VS034-T2 2869859 2724856 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51802355 COSM6941144 124948406 c.1154C>T p.P385L Substitution - Missense 38 7:55156779-55156779 + - NEUTRAL .29418 Confirmed somatic variant 26950094 surgery - NOS NS 75 ENSP00000413843.2:p.Pro385Leu ENST00000420316.6:c.1154C>T 7:g.55156779C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 B105-1-Tumor 2185975 2054272 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51856654 COSM4006732 124957347 c.1213A>G p.S405G Substitution - Missense 38 7:55156838-55156838 + - NEUTRAL .0244 Confirmed somatic variant 581 NS NS ENSP00000413843.2:p.Ser405Gly ENST00000420316.6:c.1213A>G 7:g.55156838A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0011219-T01-IM5 2726835 2585656 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51827895 COSM3412174 124949492 c.685A>T p.S229C Substitution - Missense het 38 7:55152602-55152602 + - PATHOGENIC .98092 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ser229Cys ENST00000420316.6:c.685A>T 7:g.55152602A>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0000918-T01-IM3 2716255 2575076 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2372112 2372112 2234905 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_III anaplastic NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 25694352 surgery fresh/frozen NS 28 ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 95504 1973048 1859292 large_intestine colon NS NS carcinoma adenocarcinoma NS NS n COSV51812284 COSM1651737 124963886 c.821C>T p.T274M Substitution - Missense 38 7:55154084-55154084 + - PATHOGENIC .92031 Confirmed somatic variant 23680147 surgery - NOS primary ENSP00000413843.2:p.Thr274Met ENST00000420316.6:c.821C>T 7:g.55154084C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-GN-A269-01 2121799 1996035 skin NS NS NS malignant_melanoma NS NS NS y COSV51823432 COSM3639727 124952672 c.701A>G p.N234S Substitution - Missense 38 7:55152618-55152618 + - PATHOGENIC .95999 Confirmed somatic variant 540 NS NS 70 ENSP00000413843.2:p.Asn234Ser ENST00000420316.6:c.701A>G 7:g.55152618A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0001042-T01-IM3 2716511 2575332 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-D3-A8GB-06 2262876 2129860 skin NS NS NS malignant_melanoma NS NS NS y COSV51776578 COSM4893368 124950328 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 540 NS NS 48 ENSP00000413843.2:p.Ser116Phe ENST00000420316.6:c.347C>T 7:g.55143411C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-EB-A431-01 2121600 1995836 skin NS NS NS malignant_melanoma NS NS NS y COSV51820698 COSM3639725 124957879 c.680C>T p.S227F Substitution - Missense 38 7:55152597-55152597 + - NEUTRAL .18615 Confirmed somatic variant 540 NS NS 34 ENSP00000413843.2:p.Ser227Phe ENST00000420316.6:c.680C>T 7:g.55152597C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GBM12 2144553 2013767 central_nervous_system thalamus NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 24285547 surgery fresh/frozen primary 64 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 T3265 2658621 2518780 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51815655 COSM6652276 124971611 c.913G>A p.G305S Substitution - Missense 38 7:55155853-55155853 + - PATHOGENIC .97718 Confirmed somatic variant 27149842 NS NS 74.91 ENSP00000413843.2:p.Gly305Ser ENST00000420316.6:c.913G>A 7:g.55155853G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-A6S1-01 2263260 2130244 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS primary 53 ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-GN-A266-06 2121796 1996032 skin NS NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 124956593 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 540 NS NS 45 ENSP00000413843.2:p.His47Tyr ENST00000420316.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 CHG-98T 2634280 2494676 liver NS NS NS other neoplasm NS NS y COSV51850174 COSM6307834 124957236 c.350A>G p.Y117C Substitution - Missense 38 7:55143414-55143414 + - PATHOGENIC .98157 Confirmed somatic variant 660 NS primary 51 ENSP00000413843.2:p.Tyr117Cys ENST00000420316.6:c.350A>G 7:g.55143414A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-12-0656-01 2178172 2046470 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768139 COSM21685 124948622 c.866C>A p.A289D Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .99117 Confirmed somatic variant 329 NS NS 48 ENSP00000413843.2:p.Ala289Asp ENST00000420316.6:c.866C>A 7:g.55154129C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0211-01 1910206 1798497 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51768130 COSM21684 124949356 c.787A>C p.T263P Substitution - Missense 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 329 fresh/frozen - NOS primary 48 ENSP00000413843.2:p.Thr263Pro ENST00000420316.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003016-T01-IM3 2719225 2578046 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51839629 COSM6925694 124960501 c.389C>T p.T130I Substitution - Missense het 38 7:55143453-55143453 + - NEUTRAL .47678 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Thr130Ile ENST00000420316.6:c.389C>T 7:g.55143453C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0006846-T01-IM5 2723226 2582047 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51781750 COSM6954369 124956646 c.954G>A p.M318I Substitution - Missense het 38 7:55155894-55155894 + - PATHOGENIC .91367 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Met318Ile ENST00000420316.6:c.954G>A 7:g.55155894G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2372112 2372112 2234905 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_III anaplastic NS n COSV51822289 COSM42977 124956750 c.315G>T p.Q105H Substitution - Missense 38 7:55143379-55143379 + - PATHOGENIC .90579 Confirmed somatic variant 25694352 surgery fresh/frozen NS 28 ENSP00000413843.2:p.Gln105His ENST00000420316.6:c.315G>T 7:g.55143379G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51812540 COSM1451536 124954910 c.322A>G p.R108G Substitution - Missense 38 7:55143386-55143386 + - PATHOGENIC .72671 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000413843.2:p.Arg108Gly ENST00000420316.6:c.322A>G 7:g.55143386A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003079-T01-IM5 2719588 2578409 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense het 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 Au2 2466841 2329672 skin scalp NS NS malignant_melanoma desmoplastic NS NS y COSV51779748 COSM3639716 124956593 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26343386 surgery fresh/frozen NS 85 ENSP00000413843.2:p.His47Tyr ENST00000420316.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-FG-A87Q-01 2339613 2204596 central_nervous_system brain NS NS glioma NS NS NS y COSV99289246 COSM8268187 124949177 c.788C>T p.T263I Substitution - Missense 38 7:55154051-55154051 + - PATHOGENIC .89815 Confirmed somatic variant 545 NS primary 61 ENSP00000413843.2:p.Thr263Ile ENST00000420316.6:c.788C>T 7:g.55154051C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-A2-A4S3-01 2187874 2056152 breast NS NS NS carcinoma NS NS NS y COSV51810209 COSM3833026 124949713 c.941A>G p.D314G Substitution - Missense 38 7:55155881-55155881 + - PATHOGENIC .96368 Confirmed somatic variant 414 NS NS 59 ENSP00000413843.2:p.Asp314Gly ENST00000420316.6:c.941A>G 7:g.55155881A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 T1803 2658686 2518845 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51850996 COSM6652242 124953205 c.1192G>A p.V398I Substitution - Missense 38 7:55156817-55156817 + - PATHOGENIC .99161 Confirmed somatic variant 27149842 NS NS 63 ENSP00000413843.2:p.Val398Ile ENST00000420316.6:c.1192G>A 7:g.55156817G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 CH-LA8 2211434 2079637 lung NS NS NS carcinoma adenocarcinoma NS NS y COSV51855488 COSM4166393 124952901 c.710C>T p.A237V Substitution - Missense 38 7:55152627-55152627 + - PATHOGENIC .99229 Confirmed somatic variant 24449147 surgery fresh/frozen NS 67 ENSP00000413843.2:p.Ala237Val ENST00000420316.6:c.710C>T 7:g.55152627C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-19-1789-01 2178219 2046517 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51850088 COSM2156010 124956911 c.1000C>T p.R334C Substitution - Missense 38 7:55155940-55155940 + - PATHOGENIC .91604 Confirmed somatic variant 329 NS NS 69 ENSP00000413843.2:p.Arg334Cys ENST00000420316.6:c.1000C>T 7:g.55155940C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0006846-T01-IM5 2723226 2582047 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0012402-T01-IM5 2727458 2586279 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS n COSV51850996 COSM6652242 124953205 c.1192G>A p.V398I Substitution - Missense het 38 7:55156817-55156817 + - PATHOGENIC .99161 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Val398Ile ENST00000420316.6:c.1192G>A 7:g.55156817G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0005945-T01-IM5 2722328 2581149 haematopoietic_and_lymphoid_tissue lymph_node NS NS lymphoid_neoplasm follicular_lymphoma NS NS n COSV51837186 COSM1090861 124952337 c.442G>A p.V148M Substitution - Missense het 38 7:55146623-55146623 + - PATHOGENIC .99004 Confirmed somatic variant 28481359 surgery - NOS metastasis ENSP00000413843.2:p.Val148Met ENST00000420316.6:c.442G>A 7:g.55146623G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GBM_IV-19 2354288 2218446 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 25471132 surgery fresh/frozen primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009451-T01-IM5 2725378 2584199 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0002265-T02-IM5 2719496 2578317 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 5-VS098-T1 2869935 2724932 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV105110457 COSM9807780 124958515 c.1165C>T p.P389S Substitution - Missense 38 7:55156790-55156790 + - PATHOGENIC .99297 Confirmed somatic variant 26950094 surgery - NOS NS 84 ENSP00000413843.2:p.Pro389Ser ENST00000420316.6:c.1165C>T 7:g.55156790C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-B0-4822-01 2120426 1994662 kidney NS NS NS carcinoma clear_cell_renal_cell_carcinoma NS NS y COSV51848907 COSM3366976 124955833 c.976T>C p.C326R Substitution - Missense 38 7:55155916-55155916 + - PATHOGENIC .98755 Confirmed somatic variant 416 NS NS 78 ENSP00000413843.2:p.Cys326Arg ENST00000420316.6:c.976T>C 7:g.55155916T>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-DU-A5TY-01 2194202 2062480 central_nervous_system brain NS NS glioma NS NS NS y COSV51765897 COSM3929120 124967069 c.961G>T p.D321Y Substitution - Missense 38 7:55155901-55155901 + - PATHOGENIC .95198 Confirmed somatic variant 545 NS NS 46 ENSP00000413843.2:p.Asp321Tyr ENST00000420316.6:c.961G>T 7:g.55155901G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S001102 1027688 944664 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51768130 COSM21684 124949356 c.787A>C p.T263P Substitution - Missense het 38 7:55154050-55154050 + - PATHOGENIC .88933 Confirmed somatic variant 17177598 fresh/frozen - NOS NS ENSP00000413843.2:p.Thr263Pro ENST00000420316.6:c.787A>C 7:g.55154050A>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-E1-A7YD-01 2386254 2249086 central_nervous_system brain NS NS glioma NS NS NS y COSV51785554 COSM21688 124947980 c.971G>T p.R324L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 545 NS primary 57 ENSP00000413843.2:p.Arg324Leu ENST00000420316.6:c.971G>T 7:g.55155911G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-DU-A5TY-01 2194202 2062480 central_nervous_system brain NS NS glioma NS NS NS y COSV51765881 COSM3929118 124967057 c.949G>A p.E317K Substitution - Missense 38 7:55155889-55155889 + - PATHOGENIC .99356 Confirmed somatic variant 545 NS NS 46 ENSP00000413843.2:p.Glu317Lys ENST00000420316.6:c.949G>A 7:g.55155889G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-MV-A51V-01 2193279 2061557 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51815409 COSM7143473 124952815 c.1169A>G p.Q390R Substitution - Missense 38 7:55156794-55156794 + - NEUTRAL .3199 Confirmed somatic variant 413 NS NS 75 ENSP00000413843.2:p.Gln390Arg ENST00000420316.6:c.1169A>G 7:g.55156794A>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0009451-T01-IM5 2725378 2584199 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51781835 COSM174732 124949519 c.340G>A p.E114K Substitution - Missense het 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Glu114Lys ENST00000420316.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-76-4927-01 2120379 1994615 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 58 ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0012360-T01-IM5 2727428 2586249 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766433 COSM21683 124948886 c.323G>A p.R108K Substitution - Missense het 38 7:55143387-55143387 + - PATHOGENIC .99561 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg108Lys ENST00000420316.6:c.323G>A 7:g.55143387G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003456-T01-IM5 2719933 2578754 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51767495 COSM35752 124950070 c.754C>T p.R252C Substitution - Missense het 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg252Cys ENST00000420316.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0008257-T01-IM5 2724396 2583217 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51766389 COSM43067 124957660 c.874G>T p.V292L Substitution - Missense het 38 7:55154137-55154137 + - PATHOGENIC .98997 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Val292Leu ENST00000420316.6:c.874G>T 7:g.55154137G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 S04-45633-TP 2366567 2229450 skin NS NS NS carcinoma squamous_cell_carcinoma NS NS n COSV51801901 COSM4992959 124963072 c.448T>G p.F150V Substitution - Missense het 38 7:55146629-55146629 + - PATHOGENIC .92059 Confirmed somatic variant 25589618 fixed - NOS metastasis ENSP00000413843.2:p.Phe150Val ENST00000420316.6:c.448T>G 7:g.55146629T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 zcc203 2873641 2728634 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS y COSV99297135 COSM9212199 124954770 c.865G>T p.A289S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 33020650 surgery fresh/frozen NS ENSP00000413843.2:p.Ala289Ser ENST00000420316.6:c.865G>T 7:g.55154128G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0000370-T01-IM3 2715141 2573962 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51849071 COSM6910043 124968760 c.831_832delinsTT p.M277_D278delinsIY Substitution - Missense het 38 7:55154094-55154095 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Met277_Asp278delinsIleTyr ENST00000420316.6:c.831_832delinsTT 7:g.55154094_55154095delinsTT EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2492700 2492700 2355315 skin face NS NS malignant_melanoma NS NS NS y COSV51779748 COSM3639716 124956593 c.139C>T p.H47Y Substitution - Missense 38 7:55142336-55142336 + - PATHOGENIC .99616 Confirmed somatic variant 26286987 surgery fresh/frozen primary ENSP00000413843.2:p.His47Tyr ENST00000420316.6:c.139C>T 7:g.55142336C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 R074-I1 2813495 2669887 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99297135 COSM9212199 124954770 c.865G>T p.A289S Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98915 Confirmed somatic variant 28263318 surgery fresh/frozen NS 41 ENSP00000413843.2:p.Ala289Ser ENST00000420316.6:c.865G>T 7:g.55154128G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 CHG-13-09220T 2634310 2494706 liver NS NS NS other neoplasm NS NS y COSV51802176 COSM6258054 124970861 c.111G>T p.K37N Substitution - Missense 38 7:55142308-55142308 + - PATHOGENIC .84286 Confirmed somatic variant 660 NS primary 67 ENSP00000413843.2:p.Lys37Asn ENST00000420316.6:c.111G>T 7:g.55142308G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-14-1827-01 2178235 2046533 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV99295901 COSM7467664 124965858 c.368C>T p.S123F Substitution - Missense 38 7:55143432-55143432 + - PATHOGENIC .82087 Confirmed somatic variant 329 NS NS 51 ENSP00000413843.2:p.Ser123Phe ENST00000420316.6:c.368C>T 7:g.55143432C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003702-T02-IM5 2829639 2685454 breast NS NS NS carcinoma ductal_carcinoma NS NS n COSV51831642 COSM1496684 124952152 c.988G>A p.E330K Substitution - Missense 38 7:55155928-55155928 + - PATHOGENIC .94538 Confirmed somatic variant 30205045 surgery-fixed metastasis 50 ENSP00000413843.2:p.Glu330Lys ENST00000420316.6:c.988G>A 7:g.55155928G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0237 2107974 1985835 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 23917401 NS NS ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0000316-T01-IM3 2715020 2573841 lung NS NS NS carcinoma adenocarcinoma NS NS n COSV51792237 COSM6842523 124951652 c.829_830delinsGA p.M277E Substitution - Missense het 38 7:55154092-55154093 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Met277Glu ENST00000420316.6:c.829_830delinsGA 7:g.55154092_55154093delinsGA EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-32-2632-01 2120352 1994588 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765770 COSM35602 124948448 c.185T>G p.L62R Substitution - Missense 38 7:55142382-55142382 + - PATHOGENIC .98271 Confirmed somatic variant 329 NS NS 80 ENSP00000413843.2:p.Leu62Arg ENST00000420316.6:c.185T>G 7:g.55142382T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 I2L-P16-Tumor-Organoid 2433496 2296377 large_intestine colon sigmoid NS carcinoma adenocarcinoma NS NS y COSV51814923 COSM5358036 124949951 c.559T>C p.C187R Substitution - Missense het 38 7:55146740-55146740 + - PATHOGENIC .98691 Confirmed somatic variant 25957691 NS NS 67 ENSP00000413843.2:p.Cys187Arg ENST00000420316.6:c.559T>C 7:g.55146740T>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-28-1747-01 1338074 1248459 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765787 COSM2149971 124949126 c.910C>T p.H304Y Substitution - Missense 38 7:55155850-55155850 + - PATHOGENIC .92007 Confirmed somatic variant 329 surgery fresh/frozen NS 44 ENSP00000413843.2:p.His304Tyr ENST00000420316.6:c.910C>T 7:g.55155850C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 BC85-ctDNA 2668219 2527792 breast NS NS NS carcinoma NS NS NS y COSV51834499 COSM6845063 124948074 c.964G>A p.G322S Substitution - Missense het 38 7:55155904-55155904 + - PATHOGENIC .98797 Confirmed somatic variant 27535334 circulating tumour metastasis ENSP00000413843.2:p.Gly322Ser ENST00000420316.6:c.964G>A 7:g.55155904G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-26-5139-01 2120327 1994563 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51856614 COSM3412172 124965979 c.668G>A p.C223Y Substitution - Missense 38 7:55152585-55152585 + - PATHOGENIC .99676 Confirmed somatic variant 329 NS NS 65 ENSP00000413843.2:p.Cys223Tyr ENST00000420316.6:c.668G>A 7:g.55152585G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0013010-T01-IM5 2803821 2660571 large_intestine rectum NS NS carcinoma adenocarcinoma NS NS n COSV51866279 COSM6926300 124949157 c.665G>A p.R222H Substitution - Missense het 38 7:55152582-55152582 + - PATHOGENIC .99652 Confirmed somatic variant 29316426 surgery-fixed primary 64 ENSP00000413843.2:p.Arg222His ENST00000420316.6:c.665G>A 7:g.55152582G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 CHG-13-08087T 2634306 2494702 liver NS NS NS other neoplasm NS NS y COSV51836185 COSM4884832 124959087 c.739G>T p.D247Y Substitution - Missense 38 7:55152656-55152656 + - PATHOGENIC .99163 Confirmed somatic variant 660 NS primary 46 ENSP00000413843.2:p.Asp247Tyr ENST00000420316.6:c.739G>T 7:g.55152656G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0010864-T01-IM5 2726533 2585354 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51864573 COSM6977465 124950990 c.1117C>T p.P373S Substitution - Missense het 38 7:55156643-55156643 + - PATHOGENIC .91736 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Pro373Ser ENST00000420316.6:c.1117C>T 7:g.55156643C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-TM-A7C3-01 2262979 2129963 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 43 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 5-VS094-T1 2869927 2724924 skin NS NS NS carcinoma basal_cell_carcinoma NS NS n COSV51776578 COSM4893368 124950328 c.347C>T p.S116F Substitution - Missense 38 7:55143411-55143411 + - NEUTRAL .47928 Confirmed somatic variant 26950094 surgery - NOS NS 84 ENSP00000413843.2:p.Ser116Phe ENST00000420316.6:c.347C>T 7:g.55143411C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003068-T01-IM5 2719577 2578398 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51843270 COSM6926023 124956759 c.1088C>A p.T363N Substitution - Missense het 38 7:55156614-55156614 + - PATHOGENIC .99429 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Thr363Asn ENST00000420316.6:c.1088C>A 7:g.55156614C>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-AA-A00N-01 1651102 1565889 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51852585 COSM274945 124951956 c.926G>A p.R309Q Substitution - Missense 38 7:55155866-55155866 + - PATHOGENIC .98601 Confirmed somatic variant 22810696 376 NS NS 75 ENSP00000413843.2:p.Arg309Gln ENST00000420316.6:c.926G>A 7:g.55155866G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 2696711 2696711 2555615 oesophagus upper_third NS NS other metaplasia epidermoid NS n COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 28731047 surgery-fixed primary 62 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0007076-T03-IM5 2723450 2582271 pancreas NS NS NS carcinoid-endocrine_tumour NS NS NS n COSV51860919 COSM6961890 124971526 c.593G>A p.S198N Substitution - Missense het 38 7:55151327-55151327 + - PATHOGENIC .89951 Confirmed somatic variant 28481359 surgery-fixed metastasis ENSP00000413843.2:p.Ser198Asn ENST00000420316.6:c.593G>A 7:g.55151327G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003850-T01-IM5 2720342 2579163 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-76-4926-01 2120378 1994614 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 329 NS NS 68 ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 R074-I1 2813495 2669887 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 41 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-56-8304-01 2385872 2248704 lung NS NS NS carcinoma squamous_cell_carcinoma NS NS y COSV99294789 COSM8694245 124957023 c.259G>T p.G87C Substitution - Missense 38 7:55143323-55143323 + - PATHOGENIC .99526 Confirmed somatic variant 418 NS primary 73 ENSP00000413843.2:p.Gly87Cys ENST00000420316.6:c.259G>T 7:g.55143323G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-DU-5852-01 2194247 2062525 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 124950070 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS NS 61 ENSP00000413843.2:p.Arg252Cys ENST00000420316.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-E1-A7YJ-01 2457421 2320258 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 124950070 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS primary 55 ENSP00000413843.2:p.Arg252Cys ENST00000420316.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-KT-A7W1-01 2262770 2129754 central_nervous_system brain NS NS glioma NS NS NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 545 NS primary 45 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 zcc203 2873641 2728634 central_nervous_system brain NS NS glioma diffuse_midline_glioma NS NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 33020650 surgery fresh/frozen NS ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GBM9-I2 2813459 2669851 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28263318 surgery fresh/frozen NS 63 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0005852-T02-IM5 2722238 2581059 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense het 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-BT-A42E-01 2193275 2061553 urinary_tract bladder NS NS carcinoma NS NS NS y COSV51814701 COSM7084541 124948186 c.361G>T p.V121F Substitution - Missense 38 7:55143425-55143425 + - PATHOGENIC .99041 Confirmed somatic variant 413 NS NS 74 ENSP00000413843.2:p.Val121Phe ENST00000420316.6:c.361G>T 7:g.55143425G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 T660 2296260 2161863 large_intestine caecum NS NS carcinoma adenocarcinoma NS NS y COSV51781835 COSM174732 124949519 c.340G>A p.E114K Substitution - Missense 38 7:55143404-55143404 + - PATHOGENIC .98425 Confirmed somatic variant 25344691 NS NS 66.58 ENSP00000413843.2:p.Glu114Lys ENST00000420316.6:c.340G>A 7:g.55143404G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-DU-8158-01 2194237 2062515 central_nervous_system brain NS NS glioma NS NS NS y COSV51771223 COSM3929114 124950425 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 545 NS NS 57 ENSP00000413843.2:p.Glu84Val ENST00000420316.6:c.251A>T 7:g.55143315A>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 CHC892T 2340454 2205437 liver NS NS NS carcinoma hepatocellular_carcinoma NS NS y COSV51853321 COSM3412170 124960695 c.478G>A p.E160K Substitution - Missense 38 7:55146659-55146659 + - PATHOGENIC .9774 Confirmed somatic variant 381 NS primary 72 ENSP00000413843.2:p.Glu160Lys ENST00000420316.6:c.478G>A 7:g.55146659G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-A8-A094-01 1779383 1683382 breast NS NS NS carcinoma NS NS NS y COSV51768800 COSM6499385 124955776 c.844G>A p.E282K Substitution - Missense 38 7:55154107-55154107 + - PATHOGENIC .81806 Confirmed somatic variant 414 fresh/frozen - NOS primary 75 ENSP00000413843.2:p.Glu282Lys ENST00000420316.6:c.844G>A 7:g.55154107G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0154 2107952 1985813 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 23917401 NS NS ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-AA-3811-01 1651034 1565821 large_intestine colon ascending NS carcinoma adenocarcinoma NS NS y COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 376 NS NS 84 ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 DUMC-22 2748718 2607421 central_nervous_system parietal_lobe NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51771223 COSM3929114 124950425 c.251A>T p.E84V Substitution - Missense 38 7:55143315-55143315 + - PATHOGENIC .99176 Confirmed somatic variant 29802247 surgery fresh/frozen NS 62 ENSP00000413843.2:p.Glu84Val ENST00000420316.6:c.251A>T 7:g.55143315A>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P121 2072581 1951936 central_nervous_system brain NS NS glioma astrocytoma_Grade_III anaplastic NS y COSV51785554 COSM21688 124947980 c.971G>T p.R324L Substitution - Missense 38 7:55155911-55155911 + - PATHOGENIC .97287 Confirmed somatic variant 24140581 fresh/frozen - NOS NS 57.59 ENSP00000413843.2:p.Arg324Leu ENST00000420316.6:c.971G>T 7:g.55155911G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-TQ-A7RP-01 2457441 2320278 central_nervous_system brain NS NS glioma NS NS NS y COSV51767495 COSM35752 124950070 c.754C>T p.R252C Substitution - Missense 38 7:55154017-55154017 + - PATHOGENIC .92465 Confirmed somatic variant 545 NS primary 66 ENSP00000413843.2:p.Arg252Cys ENST00000420316.6:c.754C>T 7:g.55154017C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0006876-T01-IM5 2723256 2582077 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense het 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 1040346 1040346 956923 central_nervous_system brain NS NS glioma oligodendroglioma_Grade_II NS NS n COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 17143531 surgery fresh/frozen NS ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0003170-T01-IM5 2719663 2578484 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS n COSV51841905 COSM6926730 124948800 c.931T>C p.C311R Substitution - Missense het 38 7:55155871-55155871 + - PATHOGENIC .98694 Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Cys311Arg ENST00000420316.6:c.931T>C 7:g.55155871T>C EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-06-0878-01 1337866 1248251 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51770322 COSM21686 124947464 c.865G>A p.A289T Substitution - Missense 38 7:55154128-55154128 + - PATHOGENIC .98898 Confirmed somatic variant 329 surgery fresh/frozen NS 74 ENSP00000413843.2:p.Ala289Thr ENST00000420316.6:c.865G>A 7:g.55154128G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 T116 2658237 2518396 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51773524 COSM1090858 124948180 c.418T>G p.L140V Substitution - Missense 38 7:55143482-55143482 + - NEUTRAL .25717 Confirmed somatic variant 27149842 NS NS 52.58 ENSP00000413843.2:p.Leu140Val ENST00000420316.6:c.418T>G 7:g.55143482T>G EGFR_ENST00000420316 ENST00000420316.6 1218 3236 P-0012194-T01-IM5 2727317 2586138 skin NS NS NS malignant_melanoma NS NS NS n COSV51860991 COSM6983544 124950805 c.97_98delinsAA p.G33N Substitution - Missense het 38 7:55142294-55142295 + - Confirmed somatic variant 28481359 surgery-fixed primary ENSP00000413843.2:p.Gly33Asn ENST00000420316.6:c.97_98delinsAA 7:g.55142294_55142295delinsAA EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-A7-A6VX-01 2262909 2129893 breast NS NS NS carcinoma NS NS NS y COSV99294439 COSM7672524 124956144 c.439G>A p.A147T Substitution - Missense 38 7:55146620-55146620 + - PATHOGENIC .9897 Confirmed somatic variant 414 NS primary 68 ENSP00000413843.2:p.Ala147Thr ENST00000420316.6:c.439G>A 7:g.55146620G>A EGFR_ENST00000420316 ENST00000420316.6 1218 3236 TCGA-4W-AA9T-01 2339571 2204554 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51765841 COSM21687 124948911 c.866C>T p.A289V Substitution - Missense 38 7:55154129-55154129 + - PATHOGENIC .98876 Confirmed somatic variant 329 NS primary 54 ENSP00000413843.2:p.Ala289Val ENST00000420316.6:c.866C>T 7:g.55154129C>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 T116 2658237 2518396 large_intestine NS NS NS carcinoma adenocarcinoma NS NS y COSV51787894 COSM6652229 124960394 c.84G>T p.K28N Substitution - Missense 38 7:55019361-55019361 + - NEUTRAL .32765 Confirmed somatic variant 27149842 NS NS 52.58 ENSP00000413843.2:p.Lys28Asn ENST00000420316.6:c.84G>T 7:g.55019361G>T EGFR_ENST00000420316 ENST00000420316.6 1218 3236 GB052T 2634017 2494413 central_nervous_system brain NS NS glioma astrocytoma_Grade_IV glioblastoma_multiforme NS y COSV51784086 COSM35508 124947750 c.664C>T p.R222C Substitution - Missense 38 7:55152581-55152581 + - PATHOGENIC .97679 Confirmed somatic variant 672 NS primary ENSP00000413843.2:p.Arg222Cys ENST00000420316.6:c.664C>T 7:g.55152581C>T